Lecture 5 - jan.ucc.nau.edu

Membrane Transport
Chapter 11
Transcellular transport of glucose
The Na+ - K+ pump is an ATPase
Response of red blood cells to changes in
osmolarity of extra cellular fluids
Distribution of phospholipids and glycolipids in
the lipid bilayer of human red blood cells
Few Ions are required to cause a large change in
membrane potential
Electrochemical gradient vs. membrane potential
Can work additively or against each other
Selectivity of a K+ channel
Ion Channels fluctuate between closed and open
conformations
Gating of K+ channel
Gating of Ion Channels
A Typical Vertebrate Neuron
Ball and Chain Model of Rapid inactivation of
ion channel
Changes in Na+ channels and the action potential
Changes in Na+ channels and the action
potential
Myelination
Schwann cells and myelination of axons
Patch Clamp Recording
Patch Clamp Recording
Patch Clamp Measurements of single voltage
gated Na+ channel
3 experiments on
the same patch
cumulative of 144
experiments
Resting Chemical Synapse
Active Chemical Synapse
Neuromuscular Junction in a Frog
Three Conformations of Acetyl Choline receptor
at the neuromuscular junction
DVD Clip 49
Ion Channels at Neuromuscular Junction
Motor Neuron Cell body in the Spinal Chord
Motor Neuron Cell body in the Spinal Chord
thousands of axon
terminals are
stained red
by antibody
that recognizes
a protein in
synaptic vesicles