Fructose Stimulates Na/H Exchange Activity and Sensitizes
the Proximal Tubule to Angiotensin IINovelty and
Significance
by Pablo D. Cabral, Nancy J. Hong, Md. Abdul Hye Khan, Pablo A. Ortiz, William H.
Beierwaltes, John D. Imig, and Jeffrey L. Garvin
Hypertension
Volume 63(3):e68-e73
February 12, 2014
Copyright © American Heart Association, Inc. All rights reserved.
Effect of 20% fructose in the diet on systolic blood pressure in animals fed either a normal or a
high-salt diet.
Pablo D. Cabral et al. Hypertension. 2014;63:e68-e73
Copyright © American Heart Association, Inc. All rights reserved.
Effect of substituting 5 mmol/L glucose with 5 mmol/L fructose in the absence or presence of
staurosporine on the rate of intracellular pH (pHi) recovery in proximal tubules (*P<0.02; n=8
compared with a basal pHi recovery rate in the presence of 5.5 mmol/L glucose and n=6
compared with a basal pHi recovery rate in the presence of 5.5 mmol/L glucose).
Pablo D. Cabral et al. Hypertension. 2014;63:e68-e73
Copyright © American Heart Association, Inc. All rights reserved.
Dose response of fructose.
Pablo D. Cabral et al. Hypertension. 2014;63:e68-e73
Copyright © American Heart Association, Inc. All rights reserved.
Effect of fructose on the rate of intracellular pH (pHi) recovery during inhibition of luminal
sodium/hydrogen exchanger (NHE) activity.
Pablo D. Cabral et al. Hypertension. 2014;63:e68-e73
Copyright © American Heart Association, Inc. All rights reserved.
Effect of angiotensin II 1 pmol/L on the rate of intracellular pH (pHi) recovery in the presence of
either glucose or fructose.
Pablo D. Cabral et al. Hypertension. 2014;63:e68-e73
Copyright © American Heart Association, Inc. All rights reserved.