CURRICULUM VITAE NITA SAHAI Professor, Fellow of the Mineralogical Society of America, and Ohio Research Scholar in Biomaterials Department of Polymer Science, Department of Geology, and Integrated Bioscience Program University of Akron, 170 University Ave., Akron, OH 44325-3909 e-mail: [email protected]. Phone: (330) 780-3519; website: http://biomin.uakron.edu/ Education 1998 - 2000 NSF Post-Doctoral Research Fellow. Department of Chemistry, University of Maryland, College Park. Quantum-Chemical Investigation of Silica and Apatite Biomineralization Mechanisms. Advisor: Prof. John A. Tossell 1997 - 1998 Post-Doctoral Research Associate. School of Earth and Space Exploration, Arizona State University, Tempe. X-Ray Absorption Spectroscopy Study of Strontium Adsorption at Oxide and Silicate Surfaces. Advisor: Prof. Peggy A. O’Day 1992 - 1997 Ph. D. Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, MD. Solvation and Electrostatic Model for Specific Electrolyte Adsorption. Advisor: Prof. Dimitri A. Sverjensky. 1990 - 1992 M. S., Geochemistry, University of Rochester, Rochester, NY. Calibrating the Cosmogenic 21Ne Clock. 1987 - 1990 B. Sc., 1st rank in graduating class; Geology Honors; 1st ranked student in Chemistry, Physics, Geology, French. St. Xavier’s College, Bombay University, Bombay, India. Work Experience 2011 - present Professor and Ohio Research Scholar in Biomaterials, University of Akron (UA), Akron, OH: Department of Polymer Science; Department of Geology (0% appointment); and Integrated Bioscience Program. 2010 - 2011 Professor, University of Wisconsin-Madison (UW): Department of Geoscience; Department of Chemistry (0% appointment); Materials Science Program; Environmental Chemistry and Technology Program. 2005 - 2009 Associate Professor of Geochemistry, UW. Department of Geoscience; Department of Chemistry (0% appointment); Materials Science Program; Environmental Chemistry and Technology Program. 2000 - 2004 Assistant Professor of Geochemistry (early tenure), UW: Department of Geoscience; Department of Chemistry (0% appointment); Environmental Chemistry and Technology Program. 1998 Summer Instructor, Johns Hopkins University, Baltimore, MD: Part-Time Graduate Program, School of Engineering. 1997 - 1998 Post-Doctoral Research Associate, Arizona State University, Tempe, AZ. 1990 - 1997 Graduate Research and Teaching Assistant, Johns Hopkins University, MD, and University of Rochester, NY. Research Interests: Organic molecule and cellular interactions at mineral surfaces in the origins and early evolution of life, biomineralization and environmental biogeochemistry. mineral surface-directed synthesis and self-assembly of prebiotic organic molecules to form “protocells” environmental conditions for the origins of life and habitability mechanisms of organic-mediated crystal nucleation and growth (hydroxyapatite in bone, silica and calcium carbonates in invertebrates) orthopaedic and dental biomaterials relationship between molecular-level, nanoscale and macroscopic properties 1 Techniques Used In Our Research UV-Vis and fluorescence spectroscopy; Dynamic Light Scattering; Inductively Coupled Plasma-Optical Emission Spectroscopy; Circular Dichroism; High Resolution Transmission and Scanning Electron Microscopy with Energy Dispersive X-Ray; Atomic Force Microscopy; ATR-FTIR Spectroscopy; NMR Spectroscopy; Fluorescence Microscopy; Cell-Culture and Molecular Biology assays (RTPCR, ELISA, LIVE/DEAD, and other stains, etc.); Molecular Dynamics simulations. Academic Awards and Honors 2013 - 2014 Distinguished Lecturer of the Mineralogical Society of America: nation-wide lecture tour to various Universities. 2011 - present Ohio Research Scholar in Biomaterials Chair, UA, OH. 2009 Fellow of the Mineralogical Society of America: Recognition of significant scientific contributions in the fields of crystallography, mineralogy, geochemistry, and petrology. 2009 Romnes Faculty Fellowship, University of Wisconsin – Madison (UW): Recognition of quality, significance and productivity of research, and quality and programmatic value of teaching and service. 2008 Visiting Professor Fellowship (3 weeks), Université Joseph Fourrier (University of Grenoble), France. 2004 NSF CAREER award. 1998 - 2000 NSF Post-Doctoral Fellowship. 1990 1st Rank in Graduating Class, Bombay University. Appointed to Student Council, Bombay University, India. 1987 - 1990 1st Ranked Student in Chemistry, Geology, Physics, French. St. Xavier's College, Bombay University, India. Courses Taught Graduate Courses --- Interfacial Biogeochemistry, Aquatic Chemistry, Crystal Growth and Dissolution, Minerals and Macromolecules, Astrobiology, Introduction to Biomacromolecules; Cell-Biomaterial Interactions, Connective Tissues. Undergraduate Courses (100-400 level)--- Environmental Geology, Environmental Geochemistry, Introductory Geochemistry, Fluids and Sedimentary Processes, Darwin and Evolution, Energy and Mineral Resources, Physical Geology. Research Grants 2014 – 2015 Ohio Research Scholar-Biomaterials TEEM (Techology-Enabling and Emergent Materials): Capital funds for purchasing Circular Dichroism Spectropolarimeter. $ 136,800. 2013 - 2018 Simons Foundation Origins of Life Collaboration: Potential role of minerals in prebiotic chemistry and the origins of life. P.I. N. Sahai. $ 1,254,000. Eighteen Co-P.I.s with Total Collaboration Budget of ~ $ 80 M for five years. https://www.simonsfoundation.org/life-sciences/simons-collaboration-on-the-origins-of-life/ 2013 - 2016 NSF Earth Sciences (EAR) Geobiology and Low-Temperature Geochemistry Program 151479: Mineral surface-mediated processes in protocell evolution: Membrane self-assembly and emergence of energy transduction. P.I. N. Sahai. $134,925. 2012 - 2013 NSF EAR 1255731: Acquisition of X-ray powder diffractometer. P.I. John Senko. Co-P.I.s N. Sahai, H. Barton. $115,223. 2012 - 2015 Ohio Supercomputing Center (OSC) PBS0286: Computational approach to bone biomineralization mechanisms: Molecular- to micron-scale hierarchical structure and nucleation. P.I. N. Sahai, co-P.I. Zhijun Xu, Weilong Zhao. 340,000 research units. Our group is among the top 20 Users of the OSC. 2009 - 2013 NSF DMR Bioceramics 0906817: Silicate bioceramic structure control on mesenchymal stem cell proliferation and differentiation. P. I. N. Sahai, co-P.I. William Murphy, $ 450,000; N. Sahai’s budget: $414,341. 2 2009 - 2011 NAI DDF (NASA Astrobiology Institute Director’s Discretionary Fund): Selectivity of small molecule adsorption, conformation, kinetics: Selection, preservation, and degradation of pre-biotic organics and potential biosignatures. P.I. N. Sahai, $120,599. Co-P.I.s: H. James Cleaves (Carnegie Institute of Washington), Jason Dworkin (NASA-Goddard). N. Sahai’s budget: $91,234. 2009 - 2012 NSF EAR Geobiology and Low-Temperature Geochemistry Program (Research Experience for Undergraduates) REU and Supplement To CAREER Grant: $83,446, 3 years. 2009 - 2011 Romnes Faculty Fellowship, UW: Recognition of quality, significance, and productivity of research, and quality and programmatic value of teaching and service. $50,000. 2009 - 2010 WARF (Wisconsin Alumni Research Foundation), UW: “Initiating cross-cutting energy rResearch at UW”. Four co-P.I.s, $135,453. N. Sahai’s budget: $33,860. 2008 - 2010 NSF Instrumentation and Facilities: “Acquisition of an X-ray diffraction unit for earth science research and education at the University of Wisconsin, Madison," P.I. Huifang Xu, Co-P.I.s: N. Sahai + 3 others, $148,346. 2008 - 2010 ACS-PRF (American Chemical Society Petroleum Research Fund) 47792-AC2: “Effect of organicmediated water restructuring in modifying mineral precipitation rates. P.I. N. Sahai, $100,000, 2 years. 2008 - 2009 NAI DDF (NASA Astrobiology Institute Director’s Discretionary Fund): Extracellular polymeric substances as armor against cell membrane rupture on mineral surfaces: evolution of cellularity, and potential biosignature preservation. P.I. N. Sahai, $160,266. 2006 - 2012 NAI (NASA Astrobiology Institute): Detection of the dignatures and environments of life on earth and other planetary bodies from their organic and mineralogical records. P.I. Clark Johnson. Co-Is: N. Sahai and 10 others. $6,513,430 (N. Sahai’s budget: $ 310,359). 2006 - 2007 WARF, UW 135-GG03: Structure-activity relationships of bioceramics in bone-mineral nucleation. P.I. N. Sahai. $14,045. 2006 - 2007 NSF EAR Geobiology and Low-Temperature Geochemistry Program: EAR 0628748: Partial support for short-course on Medical Mineralogy and Geochemistry. Sponsored by Reviews in Mineralogy and Geochemistry Series of the Mineralogical Society of America/Geochemical Society. P.I. N. Sahai. $22,111. 2004 - 2012 NSF CAREER Award Geobiology and Low-Temperature Geochemistry Program EAR 0346689: Mineral surface mediated organization of biological macromolecules. P.I. N. Sahai. Original: $590,779. Research Experience for undergraduates (REU) Supplement (2009): $83,446. Total Career Grant Budget: $674,225. (no cost extensions received from 2009-2012). 2004 - 2006 ACS-PRF 41777-AC2, Energetics of oxide-specific surfactant adsorption. P.I. N. Sahai. $80,000. 2003 - 2004 WARF, UW 135-2216: Phospholipid-oxide surface interactions in aqueous solutions: a thermodynamic approach. P.I. N. Sahai. $30,449. 2002 - 2005 NSF Earth Sciences (EAR) Geochemistry and Petrology Program (co-funded by NSF DMR): EAR 0208036 Role of silicon-organic interactions in silica biomineralization. PI N. Sahai, $207,723. 2002 - 2003 WARF, UW 135-0829: Experimental and theoretical investigation of organic-mediated kaolinite synthesis. P.I. N. Sahai, $22,128. 1998 - 2000 1991 NSF Post-Doctoral Fellowship to N. Sahai EAR 9805673: Surface-catalyzed apatite precipitation, $72,000. GSA and Sigma Xi student summer research grants: Isotopic study of Colorado Plateau xenoliths. 3 Peer-Reviewed Publications in Journals and Books By Subject-Area (Students’ and Post-Doctoral Scientists’ names are underlined; Senior Corresponding Author’s name is marked by an asterisk) Origins and Early Evolution of Life 1. Dalai P., Ustriyana P. and Sahai N. (in prep.) Ion tolerance of mixed lipid vesicles as model protocell membranes. For submission to 2. Sahai N.* and Schoonen M. A. (submitted) Priming the origins of life by concentrating magnesium and phosphate on prebiotic earth. Submitted to Science as a Research Article. 3. Sahai N.*, Kaddour H., Dalai P., Wang, Z., Bass, G. and Gao M. (2016, in revision) Mineral surface chemistry and nanoaggregation control membrane self-assembly. Scientific Reports. 4. Sahai N.* Kaddour H. and Dalai P. (2016) The transition from Geochemistry to Biogeochemistry. Elements 12. INVITED. Thematic issue on the Origins of Life, Guest Editors N. Sahai and H. Kaddour. 5. Dalai P., Kaddour H. and Sahai N.* (2016) Incubating Life: Prebiotic sources of organics for the chemical origins of life. Elements 12. INVITED. Thematic issue on the Origins of Life, Guest Editors N. Sahai and H. Kaddour. 6. Kaddour H. and Sahai N.* (2014) Nonenzymatic polymerization of RNA: advances and challenges. INVITED for special issue of Life 4, 598-620. 7. Greiner E., Kumar K., Sumit M., Giuffre A., Zhao W., Pedersen J. and Sahai N* (2014) Adsorption of L-glutamate and Laspartate from solution to -Al2O3. Geochim. Cosmochim. Acta 133, 142-155. 8. Xu J., Sahai N. *, Eggleston C. M. and Schoonen M. A. A. (2013) Reactive oxygen species at the oxide/water interface: Formation mechanisms and implications for prebiotic chemistry and the origin of life. Earth. Planet. Sci. Lett. 363, 156-167. 9. Xu J., Campbell J., Zhang N., Hickey W. J. and Sahai N.* (2012) Evolution of bacterial biofilms as armor against mineral toxicity. Astrobiology 12, 785-798. 10. Cleaves H. J. III*, Scott A. M., Hill F. C., Leszczynsky J., Sahai N. and Hazen R. (2012) Mineral-organic interfacial processes: potential roles in the origin of life. Chem. Soc. Rev. 41, 5365-5568. INVITED. 11. Yang Y., Sahai N.,* Romanek C. and Chakraborty S. (2012) Low-temperature dolomite (Ca, Mg(CO3)2) formation as a potential biosignature– A computational study of Mg2+ dehydration in aqueous solution in the presence of inorganic anions. Geochim. Cosmochim. Acta 88, 77-87. 12. Oleson T. A., Wesolowski D. J., Dura J. A., Majkrzak C. F., Giuffre A. J. and Sahai N.* (2012) Neutron reflectvity study of phosphatidylcholine bilayers on sapphire (110). J. Colloid. Interf. Sci. 370,192-200. 13. Oleson T. A. and Sahai N.* (2010) Interaction energies between oxide surfaces and multiple phosphatidylcholine bilayers from extended DLVO-theory. J. Colloid. Interf. Sci. 352, 316-326. 14. Oleson T. A., Sahai N.* and Pedersen J. A. (2010) Electrostatic effects on deposition of multiple phospholipid bilayers at oxide surfaces. J. Colloid. Interf. Sci. 352, 327-336. 15. Xu J., Stevens M. J., Oleson T. A., Last J. A. and Sahai N.* (2009) Role of oxide surface chemistry and phospholipid phase on adsorption and self-assembly: isotherms and atomic force microscopy. J. Phys. Chem. C 113, 2187-2196. Special issue on Physical Chemistry of Environmental Interfaces. INVITED. 16. Romanek C. S.*, Jiménez-López C., Rodriguez Navarro A., Sánchez-Román M., Sahai N. and Coleman M. (2009) Inorganic synthesis of Fe-Ca-Mg carbonates at low temperature. Geochim. Cosmochim. Acta 73, 5361-5376. 17. Oleson T. A. and Sahai N.* (2008) Oxide-dependent adsorption and self-assembly of dipalymitoylphosphatidylcholine, a cell-membrane phospholipid: Bulk adsorption isotherms. Langmuir 24, 4865-4873. 18. Sahai N.* (2002) Biomembrane phospholipid-oxide surface interactions: crystal chemical and thermodynamic basis. J. Colloid. Interf. Sci. 252, 309-319. 4 Bone Biomineralization and Biomaterials 19. Xu Z., Zhao W., Wang Z., Cui Q. and Sahai N.* (in prep.) Detailed structure analysis of collagen fibrils in distinguishing mechanisms for intrafibrillar collagen mineralization in skeletal tissues. For submission to Proc. Nat. Acad. Sci. 20. Zhao W., Wang Z., Xu Z. and Sahai N.* (in prep.) Free energy calculation reveals osteocalcin-promoted calcium phosphate nano-cluster growth. For submission to Scientific Reports. 21. Zhou X., Zhang N. and Sahai N.* (2016, in review) Silicates in orthopaedic and bone tissue engineering materials. J. Biomed. Mater. Res. Part A. 22. Zhao W., Xu Z. , Cui Q. and Sahai N.* (2016) Predicting the structure-activity relationship of hydroxyapatite-binding peptides by enhanced-sampling molecular simulation. Langmuir 32, 7009-7022. 23. Zhao W. and Sahai N.* (2016) Organic-Mineral Interactions in Biomineralization. INVITED chapter in Molecular Modeling of Biogeochemical Reactions: An Introduction, Ed. J. Kubicki. John Wiley. 24. Wang Z., Xu Z., Zhao W. and Sahai N.* (2016) Isoexergonic conformations of surface-bound citrate regulate bioinspired apatite nanocrystal growth. Applied Materials and Interfaces 8, 28116-28123. 25. Zhou X., Moussa F., Mankoci S., Ustriyana P., Zhang N., Abdelmagid S., Molenda J., Murphy W.L., Safadi F. and Sahai N.* (2016) Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. Acta Biomaterialia 39, 192-202. 26. Ye C.*, Zhou X., Telang A., Gao H., Ren Z., Qin H., Suslov S., Gill A. S., Mannava S. R., Qian D., Doll G. L., Martini A., Sahai N. and Vasudevan V. K. (2016) Surface amorphization of NiTi alloy induced by ultrasonic nanocrystal surface modification for improved mechanical properties. J. Mechan. Behav. Biomed. Mat. 53, 455-462. 27. Wang Z., Zhao W., Xu X. and Sahai N.* (2015) A potential mechanism for amino acid-controlled crystal growth of hydroxyapatite. J. Mat. Chem. B. 3, 9157-9167. 28. Zhou X. and Sahai N. * (2015) Biomimetic and nanostructured hybrid bioactive glass. Biomaterials 50, 1-9. 29. Xu Z., Yang Y., Zhao W., Wang Z., Landis W. J., Cui Q. and Sahai N.* (2015) Molecular mechanisms for intrafibrillar collagen mineralization in skeletal tissues. Biomaterials 39, 59-66. 30. Zhao W., Xu Z., Yang Y. and Sahai N.* (2014) Surface energetics of the hydroxyapatite-water interface: a molecular dynamics study. Langmuir 30, 13283-13292. 31. Xu Z., Yang Y., Cui Q. and Sahai N.* (2014) Small biomolecule-mediated hydroxyapatite growth: free energy calculations benchmarked to density functional theory. J. Comput. Chem. 35, 70-81. 32. Yang Y., Xu Z., Cui Q. and Sahai N.* (2014) Molecular simulation of biomineral nucleation and crystal growth: Modern computational challenges and approaches. INVITED chapter in Biomineralization Sourcebook: Characterization of Biominerals and Biomimetic Materials, Chapter 17, Eds. E. DiMasi and L. Gower, CRC Press, Boca Raton, FL. 33. Chapron Y.*, Charlet L. and Sahai N. (2014) Fate of pathological prion (PrPsc 92-138) in soil and water: prion-clay nanoparticle molecular dynamics. J. Biomol. Struct. Dynam. 32, 1802-1816. 34. Zhang N., Molenda J., Murphy W. and Sahai N.* (2013) Crystal structure control of CaSiO3 bioceramics on human mesenchymal stem cell attachment, proliferation and differentiation into osteoblasts. Biomat. Sci. 1, 1101-1110. 35. Yang Y., Mkhonto D., Cui Q. and Sahai N.* (2011) Theoretical study of bone sialoprotein in hydroxyapatite biomineralization. Special Issue of Cells Tissues Organs 194, 182-197. 36. Yang Y., Cui Q. and Sahai N. * (2010) How does bone sialoprotein promote the nucleation of hydroxyapatite? A molecular dynamics study using model peptides of different conformations. Langmuir 26, 9848- 9859. 37. Zhang N., Molenda J., Fournelle J., Murphy W. and Sahai N.* (2010) Effects of pseudowollastonite (-CaSiO3) on human mesenchymal stem cell activity. Biomaterials 31, 7653-7665. 38. Stevens M. J., Donato L.J., Lower S. K., and Sahai N. * (2009) Oxide-dependent adhesion of the Jurkat cell line of Tlymphocytes. Langmuir 25, 6270-6278. 39. Sahai N.* (2007) Medical Mineralogy and Geochemistry: An Interfacial Science. Elements 3, 383-386. Editor, N. Sahai. 5 40. Sahai N.*, Schoonen M., and Skinner H. C. W. (2006) The emerging field of medical mineralogy and geochemistry. INVITED, reviewed chapter for Medical Mineralogy and Geochemistry, Eds. Nita Sahai and Martin Schoonen, Reviews in Mineralogy and Geochemistry Series, Vol. 64, Mineralogical Society of America, Washington, D.C., Chapter 1. 41. Cerruti M. and Sahai N.* (2006) Silicate biomaterials for orthopaedic and dental implants. INVITED, reviewed chapter for Medical Mineralogy and Geochemistry, Eds. Nita Sahai and Martin Schoonen, Reviews in Mineralogy and Geochemistry Series, Vol. 64, Mineralogical Society of America, Washington, D.C., Chapter 9. 42. Sahai N.* (2005) Modeling apatite nucleation in the human body and in the geochemical environment, Am. J. Sci. INVITED, for special issue of Am. J. Sci. 305, 661-672. 43. Sahai N.* and Anseau M. (2005) Cyclic silicate active site and epitaxial apatite nucleation on pseudowollastonite bioceramic-bone interfaces. Biomaterials 26, 5763-5370. 44. Anseau M. R.*, Leung P., Sahai N. and Swaddle, T. W. (2005) Interactions of silicate ions with zinc(II) and aluminum(III) in alkaline aqueous solution. Inorg. Chem. 44, 8023-8032. 45. Sahai N.* (2003) The effects of Mg2+ and H+ on nucleation of authigenic apatite at silica surfaces. Geochim. Cosmochim. Acta 67, 1017-1030, INVITED. 46. Sahai N.* and Tossell J. A. (2000) Molecular orbital study of apatite nucleation at silica bioceramic surfaces. J. Phys. Chem. B. 104, 4322-4341. Environmental Geochemistry and Silica Biomineralization 47. Hochella M. F., Jr.*, Lower S. K., Maurice P. A., Penn R. L., Sahai N., Sparks D. L. and Twining B. S. (2008) Nanominerals, mineral nanoparticles, and Earth systems. Science 319, 1631-1635. 48. Ciardelli M. C., Xu H. and Sahai N.* (2008) Role of Fe(II), phosphate, silicate, sulfate and carbonate in arsenic uptake by coprecipitation in synthetic and natural groundwater. Water Res. 42, 615-624. 49. Sahai N.*, Lee Y., Xu H., Ciardelli M. C. and Gaillard J.-F. (2007) Role of Fe(II) and phosphate in arsenic uptake by coprecipitation. Geochim. Cosmochim. Acta 71, 3193-3210. 50. Sahai N.* and Rosso K. (2006) Linking molecular modeling to surface complexation modeling. INVITED, reviewed chapter in Surface Complexation Modelling, Ed. Johannes Lutzenkirchen. Interface Science and Technology Series, Vol. 11, Elsevier, Amsterdam. 51. Delak K. M. and Sahai N.* (2006) Investigations into the mechanisms of amine-catalyzed hydrolysis of organosilicates. J. Phys. Chem. B. 110, 17819-17829. 52. Delak K. M. and Sahai N.* (2005) Amine-catalyzed biomimetic hydrolysis and polymerization of organosilicate. Chem. Mater. 17, 3221-3227. 53. Delak K. M., Farrar T. C. and Sahai N.* (2005) 29Si NMR sensitivity enhancement methods for the quantitative study of organosilicate hydrolysis and condensation. J. Non-Cryst. Solids 351, 2244-2250. 54. Thornburg K. and Sahai N.* (2004) Arsenic occurrence, mobility, and retardation in sandstone and dolomite formations of the Fox River Valley, Wisconsin. Environ. Sci. Technol. 38, 5087-5094. 55. Sahai N.* (2004) Calculation of 29Si NMR shifts of silicate complexes with carbohydrates, amino-acids and carboxylic acids: Potential role in biological silica utilization. Geochim. Cosmochim. Acta 68 227-238. 56. Sahai N.* (2003b) Silicon-organic interactions in the environment and in organisms. INVITED, reviewed chapter in Geochemical and Hydrological Reactivity of Heavy Metals in Soils, eds. W. L. Kingery and H. M. Selim, Chapter 6. CRC Press, Boca Raton, FL. 57. Sahai N.* (2002a) Is silica really an anomalous oxide? Aqueous hydrolysis and surface acidity revisited. Environ. Sci. Technol. 36, 445-452. 58. Sahai N.* and Tossell J. A. (2002b) 29Si NMR shifts and relative stabilities calculated for aqueous hypervalent siliconpolyalcohol complexes: role in sol-gel and biogenic silica synthesis. Inorg. Chem. 41, 748-756. 59. Sahai N.* and Tossell J. A. (2001) Formation energies and NMR chemical shifts calculated for putative serine-silicate complexes in silica biomineralization. Geochim. Cosmochim. Acta 65, 2043-2053. 60. Tossell J. A.* and Sahai N. (2000) Calculating the acidity of silanols and related oxyacids in aqueous solution. Geochim. Cosmochim. Acta 64, 4097-4113. 6 61. Sahai N.* (2000) Estimating adsorption enthalpies and affinity sequences of monovalent electrolyte ions on oxide surfaces in aqueous solution. Geochim. Cosmochim. Acta 64, 3629-3641. 62. O' Day P.A.*, Newville M., Neuhoff P., Sahai N. and Carroll S. A. (2000) X-Ray absorption spectroscopy of strontium (II) coordination: I. static and thermal disorder in crystalline, hydrated and precipitated solids and in aqueous solution. J. Colloid. Interface Sci. 222, 184-197. 63. Sahai N., Carroll S. A., O' Day P. A.* and Roberts S. (2000) X-Ray absorption spectroscopy of strontium (II) coordination: II. Sorption and precipitation at kaolinite, amorphous silica and goethite surfaces. J. Colloid. Interface Sci. 222, 198-212. 64. Koretsky C. M.*, Sverjensky D. A. and Sahai N. (1998) Calculating site densities of oxides and silicates from crystal structures. Amer. J. Sci. 298, 349-38. 65. Sverjensky D. A. * and Sahai N.(1998) Prediction of surface-protonation enthalpies for oxides. Geochim. Cosmochim. Acta 62, 3703-3715. 66. Sahai N.* and Sverjensky D. A. (1998) GEOSURF: A computer program for modeling adsorption on mineral surfaces in solution. Computers. Geosci. 24, 853-873. 67. Sahai N.* and Sverjensky D. A. (1997a) Evaluation of internally-consistent parameters for the triple-layer model by the systematic analysis of oxide surface titration data, Geochim. Cosmochim. Acta 61, 2801-2826. 68. Sahai N.* and Sverjensky D. A. (1997b) Solvation and electrostatic model for specific electrolyte adsorption. Geochim. Cosmochim. Acta 61, 2827-2848. 69. Sverjensky D. A.* and Sahai N. (1996) Theoretical prediction of single-site surface protonation equilibrium constants for oxides and silicates in water. Geochim. Cosmochim. Acta 60, 3773-3797. Selected Symposium Abstracts and Oral Presentations (Student and Post-Doctoral Associate Names Underlined) 1. Dalai P., Ustriyana P. and Sahai N.* (2016) Ion tolerance on the integrity of mixed lipid membranes. Workshop on Searching for Life Across Space and Time, NASA and National Academy of Science, Irvine, CA, December 2016. 2. Kaddour H., Gerislioglu S., Miyoshi T., Wesdemiotis C. and Sahai N.* (2016) Non-enzymatic RNA polymerization at the mineral-water interface: An insight into the adsorption-polymerization relationships. Workshop on Searching for Life Across Space and Time, NASA and National Academy of Science, Irvine, CA, December 2016. 3. Wang Z. and Sahai N.* (2015) Osteocalcin effect on collagen fibrillogenesis and its potential role in biomineralization. Materials Research Society Fall Meeting, Boston, December 2015. 4. Zhou X., Hou X., Zhang R., Sahai N. and Ye C. (2015) Mechanical properties and biological potential of nanocrystallized NiTi alloy substrate induced by ultrasonic nanocrystal surface modification. Materials Research Society Fall Meeting, Boston.amorphous calcium phosphate nanoparticle. Materials Research Society Fall Meeting, Boston, December 2015. 5. Xu Z., Zhao W., Wang Z. and Sahai N.* (2015) Monolayer-Induced Calcium Phosphate Nucleation: A Molecular Dynamics Study. Materials Research Society Fall Meeting, Boston, December 2015. 6. Zhao W., Ling C., Wang Z., Xu Z. and Sahai N.* (2015) Conformation behavior of peptide binding to amorphous calcium phosphate nanoparticle. Materials Research Society Fall Meeting, Boston, December 2015. 7. Kaddour H. , Dalai P. , Estrada C. and Sahai N.* (2015) Potential synergism and mutualism in the origins of life: a onepot experimental approach to non-enzymatic RNA and peptide polymerization. Goldschmidt Conference. Prague, Czech Republic, August 2015. 8. Dalai P., Estrada C., Kaddour H., Bass G. and Sahai N.* (2015) Formation and stability of model membranes in geochemical environments. Goldschmidt Conference, Prague, Czech Republic, August 2015. 9. Livi K. J. T. et al. (2015) Nanoscale investigation of hydroxylapatite formation in alligator gar fish scale. Goldschmidt Conference, Prague, Czech Republic, August 2015. 10. Zhao X. and Sahai N.* (2014) POSS-Based Dendrimer Gel as Bioactive Scaffold for Adipose Tissue-Derived Stem Cell Cultivation and Osteogenic Differentiation. International Forum of Biomedical Materials (IFBM) - Nanobiomaterials and biomaterials Interfaces. Hangzhou, China, November 2014. 7 11. Sahai N.* (2014) Mechanisms of intrafibrillar calcium phosphate cluster nucleation in bone biomineralization. KEYNOTE INVITED, Geological Society of America Annual Conference, Vancouver, Canada, October 2014. 12. Sahai N.* (2014) Bone biomineralization mechanisms. INVITED, Gordon Research Conference-Biomineralization, New London, NH, August 2014. 13. Zhao X., Zhang N., Moussa F., Safadi F. and Sahai N.* (2014) Extracellular silicon directly controls bone cell differentiation and function by antagonizing activation of NF-B. Gordon Research Conference-Biomaterials, Newbury, ME, July 2014. 14. Sahai N. * (2014) Bone biomineralization mechanisms at the molecular to nanometer-scale. KEYNOTE INVITED for special symposium celebrating the 10th anniversary of the Elements journal. Goldschmidt Conference, Sacramento, CA, June 2014. 15. Sahai N. * and Maurer S. (2014) Identifying habitable environments for prebiotic model protocells. Goldschmidt Conference (annual international geochemistry conference), Sacramento, CA, June 2014. 16. Sahai N. * (2014) Bone biomineralization mechanisms from Å to mesoscale (100s of nm). Ohio State University Materials Week, Columbus, OH, May 2014. KEYNOTE INVITED. 17. Kaddour H., Sathe P., Bracamonte A. G. and Sahai N. * (2014) Mineral- or lipid bilayer-assisted polymerization of RNA: Literature review and preliminary results. Ohio State University Materials Week, Columbus, OH, May 2014. 18. Bracamonte A. G., Kaddour H., Sathe P., and Sahai N. * (2014) Trans-membrane electron transfer (TM-ETR) promoted by membrane-associated photocatalytic minerals. Ohio State University Materials Week, Columbus, OH, May 2014. 19. Sathe P., Kaddour H., and Bracamonte A. G. and Sahai N. * (2014) The potential role of minerals in the selection and stabilization of protocell membranes. Ohio State University Materials Week, Columbus, OH, May 2014. 20. Xu Z., Yang Y., Cui Q., Landis W. J. and Sahai N. * (2014) Location and orientation of charged amino acid sidechains in collagen hole and overlap zones direct intrafibrillar calcium phosphate nucleation in bone biomineralization. Ohio State University Materials Week, Columbus, OH, May 2014. 21. Zhao W., Xu Z., Cui Q. and Sahai N. * (2014) Predicting binding conformation and affinity of peptides at hydroxyapatite surface. Ohio State University Materials Week, Columbus, OH, May 2014. 22. Wang, Z., Xu Z., Zhao W. and Sahai N. * (2012) Morphology control of hydroxyapatite nanocrystals in the presence of amino acids. Ohio State University Materials Week, Columbus, OH, May 2014. 23. Zhou X. and Sahai N. * (2014) POSS-based dendrimer gel (PDG) as bioactive scaffold for adipose tissue-derived stem cell cultivation and osteogenic differentiation. Ohio State University Materials Week, Columbus, OH, May 2014. 24. Mankoci S., Zhou X. and Sahai N. * (2014) The effect of soluble silica on the differentiation of human adipose tissuederoved mesenchymal stem cells (hADMSCs) into multiple lineages. Ohio State University Materials Week, Columbus, OH, May 2014. 25. Qi L., Zhou X. and Sahai N. * (2014) Porous PLGA (polyactic-co-glycolic acid)--CaSiO3 (pseudowollastonite) composite scaffolds for optimized biocompatibility and osteoinduction. Ohio State University Materials Week, Columbus, OH, May 2014. 26. Zhao W., Xu Z., Cui Q. and Sahai N. * (2014) Predicting binding conformation and affinity of peptides at hydroxyapatite surface. American Chemical Society Spring Meeting, Dallas, March 2014. 27. Kaddour H., Sathe P., Bracamonte A. G and Sahai N. * (2014) Mineral- or lipid bilayer-assisted polymerization of RNA: Literature review and preliminary results. Simons Foundation Annual Report Meeting, April 2014, NY, NY. 28. Bracamonte A. G., Kaddour H., Sathe P. and Sahai N. * (2014) Trans-membrane electron transfer (TM-ETR) promoted by membrane-associated photocatalytic minerals. Simons Foundation Annual Report Meeting, April 2014, NY, NY. 29. Sathe P., Kaddour H., Bracamonte A. G. and Sahai N. * (2014) The potential role of minerals in the selection and stabilization of protocell membranes. Simons Foundation Annual Report Meeting, April 2014, NY, NY. 30. Bracamonte A. G., Roy S., Sathe P., Kaddour H. and Sahai N. * (2014) Transmembrane electron transfer reaction assisted by minerals. Gordon Resereach Conference-Origins of Life, Galveston, TX, January 2014. 31. Roy S., Sathe P., Kaddour H. Bracamonte A. G. and Sahai N. * (2014) Hydrodynamic approach to study thermal and ionic viability of single-chain amphiphile vesicles as a model protocell. Gordon Resereach Conference-Origins of Life, Galveston, TX, January 2014. 8 32. Xu Z., Zhao W., Cui Q. and Sahai N. * (2013) Collagen structure controls water diffusion within intrafibrillar space: implications for ion transport and calcium phosphate nucleation in bone biomineralization. International Conference on the Chemistry and Biology of Mineralized Tissue (ICCBMT), Lake Geneva, WI, October 2013. 33. Xu Z., Yang Y., Cui Q., Landis W. J. and Sahai N. * (2013) Location and orientation of charged amino acid sidechains in collagen hole and overlap zones direct intrafibrillar calcium phosphate nucleation in bone biomineralization. ICCBMT, Lake Geneva, WI, October 2013. 34. Xu Z., Zhao W., Cui Q. and Sahai N. * (2013) Ca2+ and PO4 ion transport to and calcium phosphate solid phase nucleation within collagen fibrils in bone biomineralization. Goldschmidt Conference, Florence, Italy. August 2013. 35. Sahai N. * (2012) Microbial extracellular polymeric substances (EPS) as armor against mineral nanoparticle toxicity. International Society for Environmental Biogeochemistry, Cancun, Mexico, November 2012. INVITED. 36. Sahai N. * (2012) Potential role of minerals in the origin of life. Origins of Life Workshop, Simons Foundation, NY, NY, October 2012. INVITED. 37. Xu Z., Yang Y., Cui Q. and Sahai N. * (2012) Bone biomineralization mechanisms by molecular dynamics simulation. America Chemical Society Annual Fall Meeting, Philadelphia. August 2012. INVITED. 38. Xu Z., Yang Y., Cui Q. and Sahai N. * (2012) Collagen structure and role in calcium phosphate nucleation in bone. Gordon Research Conference-Biomineralization, New London, NH, August 2012. Poster. 39. Wang, Z., Xu Z., Zhao W. and Sahai N. * (2012) Morphology control of hydroxyapatite nanocrystals in the presence of amino acids. Gordon Research Conference-Biomineralization, New London, NH, August 2012. Poster. 40. Zhao W., Xu Z. and Sahai N. * (2012) Surface energetics of hydroxyapatite and potential role in bone nano-crystal formation. Gordon Research Conference-Biomineralization, New London, NH, August 2012. Poster. 41. Sahai N. *, Xu J., Zhu C., Zhang N. and Hickey W. J. (2012) Was mineral surface toxicity an impetus for evolution of bacterial extra-cellular polymeric substances (EPS)? Goldschmidt Geochemistry Conference, Montreal, Canada, June 2012. 42. Sahai N. *, Xu J., Campbell, J. M., Hickey W. J. and Zhang N. (2011) Was mineral surface complexity and toxicity an impetus for evolution of microbial extracellular polymeric substances? American Geophysical Union Annual Fall Meeting, San Francisco, December 2011. 43. Sahai N. * (2011) Biomolecule-mineral interactions in the geochemical environment on early earth and in the human body. American Geophysical Union Annual Fall Meeting, San Francisco, December 2011. INVITED. 44. Yang Y., Qiang, C. and Sahai N. * (2010) Theoretical study of bone sialoprotein in bone biomineralization. 10 th International Conference on the Chemistry and Biology of Mineralized Tissues (ICCBMT), Scottsdale, AZ, Nov 2010. 45. Zhang N., Molenda J., Murphy W., Fournelle J. and Sahai N. * (2010) Effects of soluble factors from pseudowollastonite (-CaSiO3) dissolution on in vitro activity of human mesenchymal stem cells. 10th ICCBMT, Scottsdale, Nov 2010. 46. Sahai N. *, Zhang N., Murphy W. L., Molenda J., Yang Y. and Cui Q. (2010) Mechanisms of cellular and biomacromolecular interactions with minerals in humans. International Mineralogical Association Annual Meeting, Budapest, Hungary. PLENARY. 47. Yang Y., Cui Q. and Sahai N. * (2010) How does bone sialoprotein promote the nucleation of hydroxyapatite? A molecular dynamics study using model peptides of different conformations. Gordon Conference on Biomineralization, August 2010. 48. Zhang N., Molenda J., Murphy W. L., Fournell J. and Sahai N. * (2010) Effects of pseudowollastonite (β-CaSiO3) on in vitro activity of human mesenchymal stem cells. Gordon Research Conference-Biomineralization, August 2010. 49. Yang Y., Cui Q. and Sahai N. * (2010) How does bone sialoprotein promote the nucleation of hydroxyapatite? A molecular dynamics study using model peptides of different conformations. Mid-West Connective Tissue Conference, April 2010. 50. Zhang N., Molenda J., Murphy W. L., Fournell J. and Sahai N. * (2010) Effects of pseudowollastonite (β-CaSiO3) on in vitro activity of human mesenchymal stem cells. Mid-West Connective Tissue Conference, April 2010. 51. Zhang N., Molenda J., Murphy W. L. and Sahai N. * (2010) Effects of soluble factors from pseudowollastonite (βCaSiO3) dissolution on in vitro activity of human mesenchymal stem cells. Materials Research Society Annual Spring Meeting, San Francisco, CA. 9 52. Xu J. and Sahai N. * (2010) Extracellular polymeric substances as armor against cytotoxic minerals: survival of Pseudomonas aeruginosa cells in oxide particle suspensions. Astrobiology Science Conference, League City, TX, April 2010. 53. Xu J., Hylton S., Schoonen M. A. and Sahai N. * (2010) Exploring the Mechanisms for Highly Reactive Oxygen Species (hROS) Formation in Oxide Particle Suspensions: Implications for the Origin and Evolution of Life at Mineral Surfaces. Astrobiology Science Conference, League City, TX, April 2010. 54. Xu J. and Sahai N. * (2010) Did extracellular polymeric substances evolve to protect against toxicity of oxide particles towards cell surfaces? Gordon Conference on Origin of Life, Galveston, TX. 55. Mkhonto D. and Sahai N. * (2009) Molecular simulations of succinate adsorption at steps on calcite. Goldschmidt Conference, Davos, Switzerland. KEYNOTE. 56. Oleson T.A. and Sahai N. * (2009) Oxide charge and electric double layer control on phospholipid adsorption and selfassembly at oxide surfaces. Goldschmidt Conference, Davos, Switzerland. 57. Stevens M. J., Donato L. J., Lower S.K. & Sahai N. * (2009) Oxide dependent adhesion of the Jurkat line of Tlymphocytes. Goldschmidt Conference, Davos, Switzerland. 58. Zhang N., Molenda J., Murphy W. and Sahai N. * (2009) Effect of CaSiO3 structure and texture on the in vitro behavior of human mesenchymal stem cells. Materials Research Society Annual Spring Meeting, San Francisco, CA. 59. Mkhonto D. and Sahai N. * (2009) Modeling organic- and amino-acid adsorption on calcite. American Chemical Society Spring Meeting, Salt Lake City, UT. INVITED. 60. Mkhonto D. and Sahai N. * (2008) Molecular dynamics simulation of organic-acid adsorption on calcite. Materials Research Society Fall Meeting, Boston, MA. 61. Charlet L. *, Fernandez Martinez A, Chapron Y., Sahai N., Cuello G., Brendle J. and Marichal C. (2008) Protein adhesion and ion substitution (on/in)to minerals. American Geophysical Union Fall Meeting, San Francisco, CA. INVITED. 62. Sahai N. * (2008) Interactions between organic and mineral components: conceptual and technological gaps. Gordon Research Conference-Biomineralization, New London, NH, August 2008. Session Leader, INVITED. 63. Chapron Y., Charlet L. * and Sahai N. * (2008) Interaction of peptide PrP(92-138) and clay surface. American Chemical Society Annual Spring Meeting, New Orleans, LA, INVITED. 64. Hochella M.F. *, Jr., Lower S.K., Maurice P.A., Penn R. L., Sahai N., Sparks D. L. and Twining B. S. (2008) Nanominerals, mineral nanoparticles, and earth systems. Goldschmidt Conference, Vancouver, Canada, INVITED. 65. Sahai N. *, Oleson T., Stevens M. J. and Xu J. (2008) Biomolecule-mineral interfacial forces in cell adhesion and membrane self-assembly. American Chemical Society Annual Spring Meeting, New Orleans, LA, INVITED. 66. Mkhonto D. and Sahai N. * (2008) Modeling amino-acid adsorption on calcite. American Chemical Society Annual Spring Meeting, New Orleans, LA, INVITED. 67. Mkhonto D. and Sahai N. * (2008) Modeling acidic peptide adsorption on hydroxyapatite. Materials Research Society, Spring Meeting, San Francisco, CA. 68. Oleson T., Stevens M. and Sahai N. * (2008) Oxide-dependent phospholipid adsorption and self-assembly. Materials Research Society, Spring meeting, San Francisco, CA. 69. Oleson T. and Sahai N. * (2007) Mineral specificity of DPPC adsorption on oxide surfaces. American Chemical Society Annual Spring Meeting, Chicago, IL. 70. Stevens M. J. and Sahai N. * (2007) Atomic force microscopy study of DPPC morphology on metal oxides. American Chemical Society Annual Spring Meeting, Chicago, IL. 71. Delak K. M. and Sahai N. * (2006) Amine-promoted organosilicate hydrolysis mechanism at near-neutral pH. American Geophysical Union, Fall 2006 Meeting, San Francisco, CA. 72. Sahai N. *, Lee Y. J., Xu, H. and Ciardelli M. (2006) Phase separation of iron oxyhydroxide and iron phosphate nanoparticles influences arsenic uptake. American Chemical Society Annual Fall Meeting, San Francisco, INVITED. 73. Lee Y. J., Xu H., Ciardelli M., and Sahai N. * (2006) Investigation of Arsenic Uptake by Fe and Ca Phosphate Coprecipitates: Batch studies and HRTEM characterization. American Chemical Society Annual Spring Meeting, Atlanta. 10 74. Ciardelli M., Lee Y. J., Sahai N. * and Xu H. (2006) Effects of silicate, sulfate, and phosphate on As(III) and As(V) uptake by Fe and Ca phosphate coprecipitates. American Chemical Society Annual Spring Meeting, Atlanta. 75. Xue T., Lee Y. J., Sun X., Sahai N. *, and Xu H. (2006) Investigation of cobalt enrichment in ferromanganese crust: Highresolution TEM observation and Co(II) sorption study. GSA Annual Meeting, Philadelphia, PA. 76. Sahai N. *, Lee Y. J., Xu H. and Ciardelli M. (2005) Arsenic uptake by hydroxyapatite in the presence of Fe(II). American Geophysical Union, Annual Fall Meeting, San Francisco, CA. INVITED. 77. Sahai N. * and Delak K. M. (2005) Amine-catalyzed mechanism for nano-silica biomineralization. American Geophysical Union, Annual Fall Meeting, San Francisco, CA. INVITED. 78. Delak K. M. and Sahai N. * (2005) Synthesis and structural characterization of silica gels prepared with amine and polyamine catalysts. Materials Research Society Spring Meeting, San Francisco, CA. 79. Delak K. M. and Sahai N. * (2005) Amine-catalysis of organosilicate hydrolysis and condensation and its biological and mechanistic implications. American Chemical Society, Annual Spring Meeting, San Diego, CA. 80. Sahai N. * and Delak K. (2005) Amorphous oligomer nucleation and aggregation mechanism for biomineralization. Goldschmidt Conference, Moscow, Idaho. 81. Oleson T. and Sahai N. * (2005) Phospholipid self-assembly at oxide surfaces, Goldschmidt Conf., Moscow. INVITED 82. Oleson T.A. and Sahai N. * (2005) Sorption of a membrane phospholipid on metal oxide surfaces. American Chemical Society, Annual Spring Meeting, San Diego, CA. 83. Sahai N. * and Anseau M. (2005) Identification of active site and reaction mechanism for epitaxial apatite nucleation at the pseudowollastonite bioceramic-bone interface, Goldschmidt Conference, Moscow, Idaho. INVITED. 84. Sahai N. * and Anseau M. (2005) Cyclic silicate active site and epitaxial apatite nucleation on pseudowollastonite bioceramic-bone interfaces. American Chemical Society, Annual Spring Meeting, San Diego, CA. 85. Anseau M. R. *, Sahai N, and Swaddle T. W. (2005) Understanding the action of silicon based bioactive ceramics at the osteoblastic level. The Belgian Society of Biochemistry and Molecular Biology (BMB), 190 th Meeting, Belgium. 86. Anseau M. R., Leung J., Swaddle T. W. * and Sahai N. (2005) Reaction of aqueous silicate ions from bioactive ceramics. Canadian Chemistry Conference, 88th Meeting, Saskatoon, Canada. 87. Raaum S., Brownson J.R.S., Kornishi H., Xu H. and Sahai N. * (2005) Effects of Si, pH, and Organic acids on kaolinite formation at low temperature, 6th Keele Meeting on Aluminum, Bussaco, Portugal. 88. Sahai N. *, Raaum, S., Kornishi, H., Brownson J.R.S., Xu H., and Oleson T. (2004) Interactions of organic acids and cellwall surfactants with common inorganic oxides and clays. Soil Sci. Soc. Am. Meeting, Seattle, WA. INVITED. 89. Sahai N. * (2004) Membranolytic ability of oxides depends on crystal chemistry and dielectric constants through interfacial solvation. Goldschmidt Conference, Copenhagen, Netherlands. 90. Sahai N. * (2004) Conceptual approaches for scaling from molecular to macroscopic levels of nucleation and precipitation. For “Conceptual model development for subsurface reactive transport modeling of inorganic contaminants, radionuclides, and nutrients”, Workshop, Federal Interagency Steering Committee on Multimedia Environmental Modeling (DOE, EPA, USGS, USNRC, USDA, USAERDC), Albuquerque, NM. INVITED. 91. Delak K. M. and Sahai N. * (2004) Influence of amines on biomimetic organosilicate hydrolysis and condensation. Biomineralization Gordon Research Conference, Colby-Sawyer College, New London, NH. 92. Delak K. M. and Sahai N. * (2004) Kinetics of amine-catalyzed silanol condensation: Implications for pathways to biogenic silica synthesis. Materials Research Society Spring Meeting, San Francisco, CA. INVITED. 93. Sahai N. * and Thornburg K. (2004) Thermodynamic and kinetic controls on naturally occurring arsenic contamination in groundwaters of the Fox River Valley, Eastern Wisconsin. ACS Spring Meeting, Annaheim, CA. 94. Sahai N. * (2003) Determining the feasibility of organosilicate utilization by diatoms for silica biomineralization. AGU Fall 2003 Meeting, San Francisco, CA. 95. Sahai N. * (2003) Computational chemistry as a tool for probing biogeochemical reactions, 2 nd Annual Mercury Conference for Undergraduate Research, Hamilton College, NY. INVITED. 96. Sahai N. * (2003) Silicon-organic interactions in organisms, Telluride Workshop "Chemical Reactivity of Aqueous Species at Mineral Surfaces", Telluride, Colorado. INVITED. 11 97. Sahai N. * (2003) Crystal-chemical and solvation model for biomembrane-oxide surface interactions. American Chemical Society Annual Spring Meeting, New Orleans. 98. Sahai N. * (2002) Kinetic Effects of Mg2+ on heterogeneous apatite nucleation at amorphous silica surfaces. Goldschmidt Conference, Davos, Switzerland. 99. Sahai N. * (2002) Modeling biomineralization using molecular orbital calculations with experimental methods. Research at the Materials and Life Sciences Interface, Centre for Fundamental Materials Research, MSU, East Lansing, MI. INVITED. 100. Sahai N. * (2001) Motivating cross-disciplinary thinking. Project Kaleidoscope National Assembly Meeting, Madison, WI. KEYNOTE INVITED. 101. Sahai N. * (2001) Oligomer nucleation and aggregation: a common motif in biomineralization? Clues from boneapatite and diatom-silica growth. Clay Minerals Society Annual Meeting, Madison, WI. INVITED. 102. Sahai N. * (2001) Is silica really an anomalous oxide? An interpretation of surface, aqueous and biological properties. International Conference on the Biogeochemistry of Trace Elements, Guelph Canada. INVITED. 103. Sahai N. * and Tossell (2001) Do hypervalent silicate complexes exist in aqueous solution? Goldschmidt Conference, Geochemical Society of America, Hot Springs, VA. 104. Sahai N. * and Tossell J. A. (2000a) 29Si NMR chemical shifts for silica-serine and silica-polyol complexes as indicators of silica biomineralization in diatoms and plants, Proc. Mat. Res. Soc. 599, 249-254. 105. Sahai N. * and Tossell (2000b) Molecular orbital study of apatite nucleation at silica bioceramic surfaces, Proc. Mat. Res. Soc. 599, 147-152. 106. Sahai N. * and Tossell J. A. (1999) Quantum chemical model for apatite biomineralization on silica bioceramics, Goldschmidt Conference, Geochemical Society of America, Boston. 107. Tossell J. A. * and Sahai N. (1999) Acidity of silica oligomers in solution and on surfaces. American Geophysical Union, Fall Meeting, San Francisco. 108. Tossell J. A. * and Sahai N. (1999) "The other nuclides". Calculating O and Na NMR shieldings in Na silicates and aluminosilicates. "Mineralogy at the Millennium", Carnegie Institute of Washington, Geophys.Lab. 109. Sahai N. * et al. (1998) EXAFS study of Sr2+ sorption on goethite, kaolinite and silica, 1999 ACS Annual Spring Meeting Abstracts, Anaheim, CA. 110. Sahai N. * (1997) Solvation and electrostatic model for ion adsorption, ACS Annual Spring Meeting Abstracts, San Francisco, CA. 111. Sahai N. * and Sverjensky D. A. (1996) Born solvation and electrostatic model for electrolyte adsorption, Gordon Research Conference on Interaction of Water with Surfaces, Poster Presentation. 112. Sahai N. * and Sverjensky D. A. (1996) Extended triple-layer model for predicting specific electrolyte adsorption, Geological Society of America (GSA) Abstracts, Annual Meeting, Denver, CO. 113. Koretsky C. M. *, Sahai N., and Sverjensky D. A. (1996) Calculation of surface site densities on a variety of oxide and silicate minerals using crystal structures and morphologies, GSA Abstracts, Annual Meeting, Denver. 114. Sahai N. * and Sverjensky D. A. (1995) Extended triple-layer model for prediction of ion adsorption, GSA Abstracts, Annual Meeting, New Orleans. 115. Sverjensky D. A. * and Sahai N. (1995) Theoretical model for prediction of the surface protonation of oxides and silicates in water, Terra Nova, v. 7, p. 210. 12 Invited Academic Seminars Other Than at Conferences 1. The potential role of minerals in the origins of life. Deparatment of Geological Sciences. Brigham Young UniversityProvo, Utah, March 2015. 2. Mineralogical Society of America Distinguished Lecturer Series (2013-2015): Indiana University, South Bend, IN; Case-Western University, Cleveland, OH; Kent State University, Kent, OH; October 2013-April 2014; UC-Riverside and UC-Santa Barbara, May 2015. 3. The potential role of minerals in protocell evolution. Department of Geology, University of Puerto Rico-Mayaguez. February 2014. 4. Biomineralization- an example: Hydroxyapatite nucleation and growth in bone. Department of Geology, University of Puerto Rico-Mayaguez. February 2014. 5. Mineral surfaces as evolutionary stress for protocell survival and as prebiotic enzymes for trans-Membrane energy transduction. Harvard Origins Institute, Harvard University, Cambridge, March 2013. 6. Bone biomineralization mechanisms and CaSiO3 bioceramics in bone tissue engineering. Department of Materials Science and Engineering, Northwestern University, Evanston, IL. May 2012. 7. The potential role of mineral surfaces in the evolution of protocell and primitive cell membranes on early earth. Integrated Bioscience Program, University of Akron, April 2012. 8. Cell-mineral interactions. Center for Fundamental Living Technology (FLinT), University of Southern Denmark, Odense, Denmark, March 2012. 9. Was mineral surface chemistry an impetus for the evolution of bacterial extracellular polymeric substances? Department of Geology, University of Akron, February 2012. 10. Medical mineralogy: Mechanisms of cellular and biomacromolecular interactions with minerals in the human body. Department of Polymer Science, University of Akron, October 2010. 11. Extracellular polymeric substances as armor against nanomineral cytotoxicity: A mechanistic approach. Molecular Paleontology and Resurrection, NASA Astrobiology Institute Workshop, November 2010. 12. Medical Mineralogy: Mechanisms of cellular and biomacromolecular interactions with minerals in the human body. Department of Polymer Science, University of Akron, October 2010. 13. Did mineral toxicity drive bacterial cell wall evolution? University of Delaware, Newark, DE, May 2010. 14. Did mineral toxicity drive bacterial cell wall evolution? School of Earth Sciences, Stanford University, Palo Alto, April 2010. 15. Interactions of amino-acids and phospholipid at mineral surfaces in pre-biotic chemistry and protocell evolution. Department of Chemistry, George Washington University, Washington, DC, February 2010. 16. Protocell membrane stability and early bacterial surface evolution at mineral surfaces. Carnegie Institute of Washington Geophysical Laboratory, Washington, DC, January 2010. 17. Interactions of amino-acids and phospholipids at mineral surfaces in pre-biotic chemistry and protocell evolution. NSF, Arlington, VA, January 2010. 18. Silicate bioceramic directed differentiation of stem cells into osteoblasts. Department of Chemistry, Rutgers University, NJ, November 2009. 19. Interactions at the organic-mineral-water interface in biomineralization. Department of Physics, Northwestern University, Evanston, IL. October 2008. 20. Biomolecule-mineral surface interactions in the origin of life. University of Grenoble, France. Jan 2008. 21. Biomolecule-mineral interactions in cell adhesion and biomineralization. Arizona State University, AZ. Oct 2007. 22. Biomolecule-mineral interactions in cell adhesion and biomineralization. Department of Earth Sciences, University of Toronto, Canada. July 2007. 23. Hydroxylapatite nucleation and growth on bone protein and bioceramic surface, Argonne National Laboratory, IL. May 2006. 24. Apatite nucleation at bioceramic and protein surfaces. Departments of Geology and Geophysics, Louisiana State University, and Department of Chemistry, Tulane University. April 2006. 13 25. Apatite nucleation at bioceramic and protein surfaces. Department of Chemistry, Central Michigan University, Mt. Pleasant, MI. February 2006. 26. Department of Geological Sciences, Northwestern University, Evanston, IL. February 2005. 27. Department of Chemistry, University of Wisconsin-Whitewater. December 2004. 28. Department of Geological Sciences, University of Michigan, Ann Arbor. November 2004. 29. Department of Geological Sciences, Virginia Tech, Blacksburg, VA. May 2004. 30. Department of Earth Science, Rice University, TX. December 2003. 31. Department of Chemistry, University of Wisconsin-Madison. October 2003. 32. Department of Geological and Atmospheric Sciences, Iowa State University, IA. April 2003. 33. Center for Fundamental Research, Michigan State University, East Lansing, MI. April 2002. 34. Department of Material Science, University of Wisconsin-Madison, February 2001. 35. Environmental Chemistry and Technology Program, University of Wisconsin-Madison, December 2001. 36. Geological Society of Washington, Washington D.C. April 2000. 37. Department of Geology and Geophysics, Yale University, New Haven, CT. March 2000. 38. Department of Geology and Geophysics, University of Wisconsin, Madison. February 2000. 39. Department of Chemistry, Hunter College, City University of New York, NY. February 2000. 40. Department of Orthopaedic Surgery, Harvard Medical School and Children’s Hospital, Boston. Jan. 2000. 41. Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA. January 2000. 42. Department of Geology, Penn State University, State College, PA. January 1998. 43. Geochemistry Division, Lawrence Livermore National Laboratory, Livermore, CA. November 1997. 44. School of Earth and Atmospheric Sciences, Georgia Tech, Atlanta, GA. January, 1997. 45. Geochemistry Division, Sandia National Laboratory, Albuquerque, NM. November 1996. 46. Department of Geology, University of Colorado at Boulder, Boulder, CO. April 1996. 47. Department of Geosciences, University of Illinois at Urbana-Champaign, IL. April 1996. Invited Synergistic Academic Activities 1. Organizing Committee-Member for National Academy of Sciences Space Studies Board and NASA Science Mission Directorate Workshop Searching for Life Across Time and Space. Th goal of the workship is to “facilitate an expert dialogue on the current status of extraterrestrial life detection and related issues.” Committee meeting in Washington 2016. Workshop in the NAS’ Beckman Center, Irvine, CA, December 2016. 2. Guest Editor, Origins of Life thematic issue of Elements magazine. Co-Editor: Dr. Hussein Kaddour. December 2016. 3. Sahai (2016) From Geochemistry to Biogeochemistry: The Origins of Life. NASA-Glenn and Northeast Ohio Biomimicry Symposium and Education Forum. August 2016. 4. Associate Editor, Geochimica et Cosmochimica Acta (2012-2015). American Mineralogist (2007-2010). Geochemical Transactions (2005-2009). 5. Short Course Selection Committee for Mineralogical Society of America’s “Reviews in Mineralogy and Geochemistry” Series. 2008-2011. 6. NSF EAR Geobiology and Low-Temperature Geochemistry Proposal Review Panel. October 2011. 7. NSF DMR (Division of Materials Research) Proposal Review Panel Member, March 2010, Washington, D.C. 8. Organizer of two symposia: “Biological and Biomimetic Crystal Growth/Dissolution Mechanisms From Computational Geochemistry”, and “”Medical Mineralogy and Geochemistry”, Goldschmidt Conference, Davos, 2009. 9. NASA Astrobiology Institute Workshop for planning Strategic Science Initiatives, Tempe, AZ, May 2009. 10. Reviewer for NASA Lunar Dust Toxicity Research Project, Human Research Program, 2008. 14 11. National Research Council-National Academy of Science. Invited speaker for Panel on “Science at the Life/Earth Materials Interface,” Washington, D. C. June 2006. 12. Panel-Member, Molecular- and Nano-Environmental Geochemistry NSF EAR proposal review panel. NSF Arlington, VA. May 2006. 13. NSF Earth Day Lecture, Arlington, VA. April 2005. 14. Represented State of Wisconsin at Congressional Visits Day, to highlight importance of Congressional funding for fundamental research and development in at Science, Engineering, Technology, Washington D.C., May 2007. 15. Guest Editor, Medical Mineralogy and Geochemistry thematic issue of Elements magazine, volume 3, published jointly by 11 international mineralogical societies, December 2007. 16. Editor and short-course Organizer, Medical Mineralogy and Geochemistry, Reviews in Mineralogy and Geochemistry, Volume 64, Mineralogical Society of America Washington, D.C. Co-Organizer and Co-Editor: Prof. Martin Schoonen, SUNY-Stony Brook, NY. December 2006. 17. Organizer and Chair, Special Symposium on “Bridging Concepts and Techniques in Molecular Biogeochemistry, Medical Mineralogy and Nanomaterials Synthesis”, ACS Annual Spring meeting, San Diego, CA. Co-chair: Dr. Jeffrey Greathouse, Sandia National Laboratories. 2005. 18. Co-Organizer, symposium on “Biomineralization: Concepts and Mechanisms”, Goldschmidt Annual Conference, Moscow, Idaho. Organizer: Peter Voice, University of Western Michigan. 2005. 19. NSF EAR Proposal Review Panel, Geobiology and Environmental Geochemistry Program, Arlington, VA, October 2004. 20. Journal Manuscripts reviewed for: Proceedings of the National Academy of Sciences, Langmuir, Journal of Biomedical Materials Research A, Journal of Structural Biology, Journal of Materials Chemistry, Journal of Physical Chemistry B, Journal of Colloid and Interface Science, IUPAC, Environmental Science and Technology, Geochimica et Cosmochimica Acta, Chemical Geology, Geochemical Transactions, Reviews in Mineralogy and Geochemistry Series Vol. 42 and Vol. 64, American Mineralogist. 21. Proposals reviewed for: NSF DMR, NSF-CHE EMSI, NSF-EAR, NSF-IRFP, NSF-INT, DOE BES, NASA-NIP, NASA-LDTR, DOD-ARO, ACS-PRF. Invited Undergraduate Teaching and Research Workshop Presentations 22. “Molecular Modeling in Environmental Chemistry”, ACS-PRF sponsored workshop. Organizer, James Kubicki, Penn State University, State College, August 2004. 23. “Conceptual model development for subsurface reactive transport modeling of inorganic contaminants, radionuclides, and nutrients”, Workshop sponsored by Federal Interagency Steering Committee on Multimedia Environmental Modeling (DOE, EPA, USGS, USNRC, USDA, USAERDC), Albuquerque, NM, April 2004. 24. 2nd Annual Mercury Conference for Undergraduate Research, NSF funded program for promoting undergraduate research in chemistry, Hamilton College, NY, July 2003. 25. "Chemical Reactivity of Aqueous Species at Mineral Surfaces", Pinhead Institute, Telluride, Colorado, June 2003. 26. Sahai N. (2001) Motivating cross-disciplinary thinking. Project Kaleidoscope National Assembly Meeting (PKAL), Madison, WI. INVITED, KEYNOTE SPEAKER. Invited Outreach: K-12, Minorities in Science and General Public 27. Sahai N. (2016) The potential role of minerals in the origins of life. “Ecophilia” public group interested in science, Cleveland Museum of Natural History. June 2016. 28. Sahai N. (2015) The potential role of minerals in the origins of life. Cleveland Science Café, July 2015. http://www.sciencecafes.org/. International Public Forum for Scientific presentations. Co-sponsored by Sigma Xi, American Scientists, NOVA (PBS) WGBH Boston. 29. Sahai N. (2016) The potential role of minerals in the origins of life. Center for Inquiry, North East Ohio Chapter, February 2016. http://www.centerforinquiry.net/ International Public Forum “to foster a secular society based on science, reason, freedom of inquiry, and humanist values.” 15 30. “Scientista” Experiences: Discussion with Graduate Women on professional and personal challenges I face as a female scientist in acadaemia. Kent State University. April 2014. 31. Mentoring and overseeing science research projects for underprivileged High School Senior and Junior students from local area high schools in Sahai’s research laboratory, Akron, OH. Two female students. 2014. 32. Public Broadcasting Service (PBS-WVIZ) Cleveland Channel, Invited talk at the Institute for the Science of Origins, Case Western Reserve University, Cleveland, Director and Host, Prof. Glenn Starkman. October 2014 (presentation) and November 27, 2014 (broadcast). 33. Invited by the Lunar and Planetary Institute (LPI) in Houston, TX, to participate in developing an Educational Module, “Explore: Life on Mars”, for Public Libraries. The modeules are targeted to 8-13 year old kids, especially girls, highlighting my personal and career path as a woman Astrobiologist, Spring 2012. 34. Interviewed on National Public Radio show “To the Best of Our Knowledge” for expertise in Origin of Life area, November 2010. http://ttbook.org/book/nita-sahai. 35. Interviewed on Hungarian National Television News for my research in “Medical Mineralogy”, Budapest, Hungary, August 2010, 36. My “Medical Mineralogy” research written up in the most subscribed Hungarian National Newspaper, Népszabadság – Világszenzáció, Budapest, Hungary, August 2010. 37. Invited speaker in Women in Science and Engineering (WISE) Seminar Series, University of Wisconsin-Madison, November 2010. 38. Astrobiology Day at Madison Mallards Minor League Baseball team, representing NASA Astrobiology Institute at University of Wisconsin, May 2010. 39. Astrobiology Day at Madison Mallards Minor League Baseball team, representing NASA Astrobiology Institute at University of Wisconsin, May 2009. 40. Diverse Scientists Panel-Member, “How I became a Scientist”, Sennett Middle School, Madison, WI, April 2009. Post-Docs And Graduate Students Supervised (30 total, current and former) Primary Supervisor for Post-Doctoral Research Associates (2 current and 9 former) 1. Dr. Punam Dalai: 2014- present: Origins of Life. 2. Dr. Hussein Kaddour: 2013- present: Origins of Life. 3. Dr. Xianfeng Zhou, 2012- present: Silica-based osteoinductive biomaterials mechanisms and design principles. Currently, Assistant Professor at Qingdao University of Science and Technology, Qingdao, China. 4. Dr. Zhijun Xu, 2011- 2016: Molecular modeling of bone biomineralization mechanisms. Currently, Assistant Professor at Nanjing Tech University, Nanjing, China. 5. Dr. Charlene Estrada: 2014- 2016: Origins of Life. Currently, Post-doctoral Associate, Geophysical Laboratory, Carnegie Institution of Washington, Washington D.C. 6. Dr. Shibsekhar Roy: 2013- 2014: Origins of Life. Currently, Post-doctoral Associate, Waterford Institute of Technology, Ireland. 7. Dr. Guillermo Bracamonte: 2013- 2014: Origins of Life. Currently, Assistant Professor, National University of Cordoba, Cordoba, Argentina 8. Dr. Sarah Maurer, 2012- 2013: Origins of Life. Currently, Assistant Professor, Central Connecticut State University, CT. 9. Dr. Yang Yang, 2009- 2011: Molecular modeling of bone biomineralization mechanisms. Currently, Assistant Professor, Rowan University, NJ. 10. Dr. Donald Mkhonto, 2006- 2009: Modeling organic-calcite interactions. Currently, Senior Researcher, Council for Scientific and Industrial Research (CSIR), South Africa. 11. Dr. Young Jae Lee 2005- 2006: Arsenic and phosphate uptake by iron oxyhydroxide coprecipitates. Currently, Professor, Seoul National University, Korea. 16 Primary Graduate Student Advisees (3 current and 16 former) 1. Putu Ditta Sarita Ustriyana, 2014- present, Polymer Science. Bone biomineralization mechanisms. 2. Kexun Chen, 2016-present, Polymer Science. Bone biomineralization mechanisms. 3. Steven Mankoci, 2012- present, Polymer Science, Ph.D. candidate. Anti-microbial materials. 4. Max Goldmerier, 2015- present, Polymer Science, M.S. Bone biomineralization mechanisms. 5. Weilong Zhao, 2011- present, Polymer Science, Ph.D. candidate. Molecular modeling of bone biomineralization mechanisms; and principles for designing bone-biomimetic materials. Currently: Post-doctoral research scientist, Merck Pharamceuticals. 6. Ziqiu Wang, 2011- present, Polymer Science, Ph.D. candidate. Bone biomineralization mechanisms; and principles for designing bone-biomimetic materials. Currently: Staff Research Scientist, Center for Molecular Microscopy, Frederick National Laboratory for Cancer Research, NIH Contractor. 7. Garrett Bass, 2015, Polymer Science, Ph.D. candidate, Origins of Life. 8. Chen Ling, 2014-2016, Polymer Science, M.S. Principles for designing bone-biomimetic materials. 9. Lin Qi, 2012-2014, M.S. CaSiO3 scaffolds for bone tissue engineering. Currently, Ph.D. candidate at Ohio State University, Columbus, OH. 10. Chunxiao Zhu, 2009- 2011, Geoscience, M.S. Early evolution of bacterial cell walls. 11. Edward Greiner, 2009- 2011, Geoscience, M.S. Self-assembly of metabolizing protocell. Currently, Environmental consultant, Itasca, Denver. 12. Jie Xu, Geoscience, 2006- 2011, Ph.D. Evolution of bacterial extracellular polymeric substances as armor against toxic mineral surfaces. Currently, Assistant Professor, University of Texas-El Paso. 13. Nianli Zhang, 2005- 2011, Materials Science Program, Ph.D. Bioceramics structure-activity relationship directing stem cell differentiation into osteoblasts. Currently, Research Scientist, Clinical Affairs Department, Orthofix Inc., Dallas, TX. 14. Timothy Oleson, 2003- 2009, Geoscience, Ph.D. Oxide- and solution-dependence of phospholipid adsorption and supported bilayer formation. Science Journalist. 15. Mark J. Stevens, 2005- 2007, Geology and Geophysics, M.S. AFM study of phospholipid sorption and Jurkat cell adhesion at mineral surfaces. Currently, R&D, organic chemical synthesis, Sigma-Aldrich (TM), Madison. 16. Katya Delak, 2001- 2005, Physical Chemistry, Ph.D. “Amine-catalyzed biomimetic silica synthesis”. Currently, Program officer, NIST International and Academic Affairs Office (IAAO), Washington, D.C. 17. Mark C. Ciardelli, 2004- 2006, M.S. “Arsenic uptake by coprecipitation in synthetic and natural Bangladesh groundwater: Effects of oxyanions, temperature and seed crystals”. Currently employed by Foth®. 18. Katie Thornberg, 2001- 2003, Geology and Geophysics, M.S.. “Characterization of arsenic occurrence, mobility and retardation in sandstone and dolomite aquifers of the Fox River Valley, Wisconsin. “Currently, St. Croix Tribal Environmental Services Coordinator, WI. 19. Jeffrey Brownson, 2000- 2002, Geology and Geophysics, M.S.. Co-Adviser: Prof. Jill Banfield. “The role of organics in the mineralization of clays” Effects of phthalic acid on low temperature (25 0C) kaolinite synthesis. Currently, Asst. Prof., Penn State University. Serving/Served On Graduate Committees of 35 students Other Than My Own (current and former): 1. 2. 3. 4. 5. 6. Nine students, Dept. of Polymer Science, UA. Twelve students, Dept. of Geoscience, UW. Two Students, Dept. Biomedical Engineering, UW. Two students, Dept. Materials Science and Engineering, UW. Eight students in the Geotechnical Engineering Program, Dept. of Civil and Environmental Engineering, UW. Five students, Dept. Soil Science, UW. 17 Undergraduate Research Students: 2003-2015 (12 total ) Vaishnavi Sharma (2016-present); Jacob Morris (2014-2015); Denyse Colon Lugo (summer 2014); Sam Harms, 2009-2010; Madhuresh Sumit, 2009 (Khorana Program student); Tony Giuffre, 2007-2009; James Driver and Rajarajan Panneerselvan, 2006-2007; Kiruba Vembu, 2005-2006; Amrik Ray, 2004-2005; Emily Kleiber, 2004-2005; Sonya Raaum, 2003-2004. High School Juniors and Seniors Research Students: 2012-present. Bryan Borodkin (2014-2015), Helen Burroughs (20132014), Erica Wolf (2012-2013), St. Vincent St. Mary High School, Akron. Department And University Service University of Akron: President’s Advisory Council; Department curriculum committee; University curriculum committee. University of Wisconsin: Council to Department Chair; Computer Committee Chair; Graduate Studies Committee; Undergraduate Studies Committee; Undergraduate Adviser, Diversity Committee. Participant in UW’s “Khorana Program”, named for Nobel Laureate, Prof. H.G. Khorana, formerly a UW faculty member. This initiative is a three-month summer exchange program between Indian and American undergraduate students in Science, Technology Engineering and Mathematics, to provide research experience and experience different cultures. Letters of Reference (Available upon request) Prof. Gordon Brown, School of Earth, Energy and Environmental Sciences, Stanford University, Stanford, CA 94305. email: [email protected]. tel: 650-723-9168. Prof. Michael Hochella, Department of Geosciences, Virginia Tech, Blacksburg, VA 24061. email: [email protected]. tel: 540-231-6227. Prof. Martin A. Schoonen, Department of Geosciences, Stony Brook University, NY 11794. email: [email protected]; tel: 631-632-8007. Prof. Carrick Eggleston, Department of Geology and Geophysics, University of Wyoming, Laramie, WY 82071. email: [email protected]. tel: 307-766-6769. Professional Affiliations Geochemical Society of America, Mineralogical Society of America, American Geophysical Union, American Chemical Society. Invited Journal Cover Page Art 2012 Cover Page Art of Volumes I Have Edited 2007 2006 (mock-up for Dec. 2016) 18
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