CourseSyllabus/Spring2017
120:402BiologyofCancer
INSTRUCTORS:
OFFICE/OFFICE
HOURS:
Nan Gao, Ph.D.
Alexis Rodriguez, Ph.D.
Life Science Center 401A
225 University Ave., Newark, NJ 07102
Friday 10-12 AM
(by appointment)
COURSELOCATION(S): Hill Hall, Room 215
EMAIL:
[email protected]
[email protected]
COURSE
WEBSITE:
Blackboard
MEETINGTIME(S):Tues & Thus: 2:30-3:50 PM
COURSEDESCRIPTIONS:
Thiscoursecomparesthebasicbiologyofnormalversusthemalignantneoplasticstateandprovidesacomprehensiveover-viewofthe
basicbiologyofcancer.
Keywords:
Cancer,CancerCell,CausesofCancer,HeredityandCancer,Oncogenes,TumorSuppressorGenes,Mutations,InvasionandMetastasis,
GrowthFactorSignaling,Diagnosis,TreatmentofCancer,CancerPrevention,HumanCarcinogens.
PREREQUISITES:
120:355(CellBiology)or120:356(MolecularBiology).[Note:thepre-requisitecoursemustbepassedwithagradeofCorbetter.]
REQUIREDTEXT:
RobertWeinberg,TheBiologyofCancer,2ndEdition;ISBN-13:978-0815342205
RECOMMENDEDFURTHERREADING:
LEARNINGOBJECTIVES/GOALS:
Uponsuccessfulcompletionofthiscourse,participantswillbeableto:
-Describehowcancerarisesanddevelopsatthemolecularandcellularlevel.
-Explaingeneticalterationsimplicatedintumorformation.
-Distinguishalterationsinoncogenesandtumorsuppressorgenes.
-Compare&contrastcellcycleregulatorymechanismsinnormalandtumorcells.
-Compare&contrastcelldeathmechanismsinnormalandtumorcells.
-Describehowcancergrowsandspreads.
-Distinguishbetweentumorigenesis,angiogenesis,andmetastasis.
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CourseSyllabus/Spring2017
120:402BiologyofCancer
SCHEDULEANDCOURSEOUTLINE:Dateslistedbyweek;lectureswillmeettwiceeveryweek,unlessotherwisenoted.
Weeklydatesofexamsandduedatesforwritingassignmentsarelisted.
WEEK
MEETINGTOPIC
NOTES/READINGASSIGNMENTS/EXAMS
01/17/17(Tue)
01/19/17(Thu)
IntroductiontoCancerBiology
UsingOnlineMedicalLiteratures(DanaLibraryElectronicClassroom)
Chapter1,2
01/24/17(Tue)
01/26/17(Thu)
ProfileofCancerCell
GrowthFactorSignaling
Chapter2,5
01/31/17(Tue)
02/02/17(Thu)
CytoplasmicSignalingCircuitryPrograms
Chapter6
02/07/17(Tue)
02/09/17(Thu)
TumorVirus
EXAM1
Chapter3
02/14/17(Tue)
02/16/17(Thu)
CellularOncogene[PaperProspectusDUE2/16/17]
Chapter4
02/21/17(Tue)
02/23/17(Thu)
TumorSuppressorGene
Chapter7
02/28/17(Tue)
03/02/17(Thu)
RBandControlofCellCycle
Chapter8
03/07/17(Tue)
03/09/17(Thu)
P53andApoptosis
EXAM2
Chapter9
03/14/17(Tue)
03/16/17(Thu)
****SpringRecess*****
03/21/17(Tue)
03/23/17(Thu)
CellImmortalizationandTumorigenesis[PaperDraftDUE3/23/17]
Chapter10
03/28/17(Tue)
03/30/17(Thu)
Multi-StepTumorigenesis,Invasion&Metastasis
Chapter11,14
04/04/17(Tue)
04/06/17(Thu)
CausesofCancer
Chapter12
04/11/17(Tue)
04/13/17(Thu)
DiscussionofPaperDrafts[PosterDraftDUE04/13/17]
04/18/17(Tue)
04/20/17(Thu)
DiscussionofPosterPresentation
EXAM3
04/25/17(Tue)
04/27/17(Thu)
PreparationforPosterPresentation
PosterPresentations[WrittenPaperDUE05/05/17]
DATEOFWITTENPAPERDUE:05/05/2017
GRADINGPOLICY:
Yourgradeforthiscoursewillbedeterminedbasedonthecategorieslistedinthetablebelow.
There will be 3 lecture exams each of which will count 20% towards the overall course grade. There will be 2 writing
assignments: a review paper and a poster presentation which will count towards the overall course grade as follows:
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EXAMI,II,III
20%,20%,20%
POSTERPRESENTATION
20%
WRITTENPAPER
20%
PointValues
PointValues
TOTAL
100
ATTENDANCE,MAKE-UP,ANDLATENESSPOLICY:
AttendancePolicyStatement(200Characters)
In-class discussion is an important part of this course. Accordingly, class attendance is mandatory. Points will be
subtracted from the overall course grade for excessive unexcused absences.
If you must miss class for a valid reason, please discuss making up the missed material with your instructor as soon as
possible.
LateAssignmentPolicyStatement(200Characters)
MissedDeadlines:1pointwillbesubtractedforeachdaytheprospectus,adraftorafinalwrittenpaperislate.
AcademicDishonesty:Thecoursehasazerotolerancepolicyforacademicdishonesty,includingplagiarismandcheating.
InstancesofdishonestywillbepunishedbyazeroontheassignmentandconsultationwiththeAcademicIntegrityOfficers
todetermineiffurtheractionisrequired.Ifyouhaveanyquestionsaboutwhatconstitutesplagiarismorcheating,please
askyourinstructorsorrefertotheacademicintegritywebsitesforRutgersandNJIT:
!
!
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http://academicintegrity.rutgers.edu/academic-integrity-at-rutgers
http://studentconduct.rutgers.edu/
http://www.njit.edu/academics/integrity.php
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