FOR SKIN
POUR LA PEAU
DERMO COSMETIC
Karen Moisturizing Lotion
The Science Behind It
· Dermatologically tested
· Hypoallergenic · Paraben free
Formats: 100 ml and 250 ml
Sackville, New Brunswick, Canada
A natural solution
for
sensitive skin
85%
Reduction in
Severity of Lesions
90%
Itching or Pruritus
Disappearance
85%
Reported Improvement of
Quality of Life
Clinical trial
test results report
up to
95%
improvement in:
70%
95%
Improvement
of Xerosis Skin
*
0%
Intolerance
or side effects
Reduction in
Number of Lesions
Recommended for Rosacea • Eczema • Dry Skin • Psoriasis
Seborrheic or Atopic Dermatitis
Intolerant Skin • Cracked Heels
*Selection of patients by Accion Psoriasis in Spain. Study performed by Dr. Sara Martin Lopez.
Lasting 4 months, with 4 medical visits under dermatologist supervision/55 patients under the study
using Karen Moisturizing Lotion as the only treatment.
Karen Moisturizing Lotion
Introduction
Karen Moisturizing Lotion was created using a unique
formula with the natural extract of not one but five strains of
marine phytoplankton, designed for the most sensitive and
intolerant skins.
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Dunaliella salina
Isochrysis galbana
Nannochloropsis gaditana
Phaeodactylum
Tetraselmis chuii
In-vitro assays have been performed in
human cells to demonstrate
its bioactivity.
Please read on for the assay results.
Phytoplankton Extract reveals itself
as an antioxidant agent
SOD is responsible for converting anion superoxide (CO-) into H2O2 and
H2O. Other enzymes such as catalases and peroxidases further transform
H2O2 into harmless products. SOD provides the highest antioxidant
protection in relation to the antioxidants.
SOD1 transcripts are up-regulated in fibroblast pretreated with easy algae
plankton extract (PM-E) and then exposed to oxidative stress.
Up-regulation of SOD1 expression suggests applications in skin
anti-flammatory processes, dermatitis, rosacea, vitiligo, burns and wounds,
photo-protection, and radiation induced fibrosis.
Phytoplankton Extract protects
against oxidative stress
Skin is a protective barrier against not only pollution and microorganisms,
but also to sunlight-induced damage. When UV is absorbed by skin it
generates reactive oxygen species (ROS) causing oxidative damage
to a range of cellular components: cell wall, proteins, lipid membranes,
mitochondria, and DNA. ROS can also induce apoptosis or necrotic
processes.
PHOTOAGING, WRINKLES, SKIN DRYNESS
Up-regulation of SOD1 expression suggests applications in skin
anti-flammatory processes, dermatitis, rosacea, vitiligo, burns and wounds,
photo-protection, and radiation induced fibrosis.
Phytoplankton Extract enhances
resistance against oxidative stress
FoxO transcription factors
control diverse cellular
functions: proliferation,
differentiation, DNA
repair, apoptosis, and
defense against metabolic
and oxidative stress.
Transcripts of FoxO3 are
up-regulated in fibroblast
exposed easy algae plankton
extract (PM-E), and under
oxidative stress when cells are
pretreated with easy algae
plankton extract (PM-E).
Stimulation of FoxO3 expression reveals potential applications in
anti-aging skin treatments.
Phytoplankton Extract
increases skin elasticity
Inhibition of elastase, and extracellular matrix protein produced by
fibroblast that causes visible signs of aging when degraded,
is a therapeutic way to treat skin wrinkles and sagging.
Phytoplankton Extract increases
cell viability and proliferation
Cell injury or oxygen substrate depletion results in a rapid decrease of
cytoplasmic ATP. Increase in cytoplasmic ATP is associated with increase in
mitochondrial activity, energy metabolism and cell proliferation.
Fibroblasts treated with two
concetrations of easy algae
plankton extract (PM-E) exhibited
an increase in ATP production of
20-50% compared to controls.
Moreover, easy algae plankton
extract (PM-E) suppressed effects
of H2O2-induced oxidative stress
on cell viability up to 70%.
Increases in intracellular levels of ATP are
associated to higher energy metabolism of skin cells.
Phytoplankton Extract
enhances skin regeneration
VEGF-A plays a role
in regulations of
angiogenesis during
wound healing in a
paracrine manner, being
induced after cutaneous
injury.
Transcript amounts of
VEGF-A are up-regulated in
fibroblast cells treated with
easy algae plankton extract
(PM-E) under oxidative stress.
Stimulation of VEGF-A expression under oxidative stress suggests
applications as a wound-healing agent.
Phytoplankton Extract
stimulates skin cell growth
CRABP2 is involved
in the regulation on
intracellular concentration
of retinoic acid (RA),
and is considered a key
marker of retinoid-like
activity in skin. Retinoids
are key regulators in
epidermal growth and
differentiation, with
beneficial effects on skin
photoaging.
CRABP2 role
Transcripts of CRABP2 are
up-regulated in fibroblast
cells treated with easy algae
plankton extract (PM-E), and
basal transcript amounts
are recovered in oxidative
stressed cells pretreated with
easy algae plankton extract
(PM-E).
Up-regulation of CRABP2 expression reveals
potential applications as a skin regeneration agent.
Phytoplankton Extract stimulates
cell proliferation and angiogenesis
In skin, hepatocyte
growth factor (HGF) is
secreted by mesenchymal
cells such as fibroblasts
stimulating mitogenesis,
cell motility, angiogenesis,
and tissue regeneration.
HGF transcripts are upregulated in fibroblast cells
treated with easy algae
plankton extract (PM-E), and
allows transcript amount
recovery at control levels in
stressed cells.
Up-regulation of HGF expression
suggests applications in skin regeneration.
Phytoplankton Extract
exibits anti-apoptotic properties
HSPB1 (also referred to
as HSP27) is known to
prevent apoptosoma
assembly, release of
cytochrome c from
mitochondria, and
caspase-9 and -3
activation. Thus it
protects cells against
apoptosis triggered by
oxidatve stress and other
stimuli.
HSPB1 transcripts are upregulated in fibroblast cells
treated with easy algae
plankton extract (PM-E).
Up-regulation of HSBP1 expression
protects cells from entering apoptosis.
Phytoplankton Extract
strenghtens skin hydration
APQ3 is a water and
glycerol transporter,
being involved not only
in skin hydration but also
in cell proliferation and
wound healing. Thus, it is
a key player in epidermal
biology.
Transcript amounts of AQP3
are up-regulated in fibroblast
cells treated with easy algae
plankton extract (PM-E) even
under oxidative stress.
Up-regulation of AQP3 expression even under stress suggests
applications as a moisturizing and wound-healing agent,
as well as in skin regeneration.
Phytoplankton Extract
possesses wound-healing properties
COL6A1 forms a microfibrillar
network in extracellular
matrix that anchors nerves,
blodd vessels as well as larger
collagen fibrils, and belongs
to the superfamily proteins
containing VWA domains
mediating protein-protein
interactions.
COL6A1 Network
Transcripts of COL6A1 are
up-regulated in fibroblast
cells treated with easy algae
plankton extract (PM-E) even
under oxidative stress.
Stimulation of COL6A1 expression
suggests applications in skin regeneration.
Phytoplankton Extract
reveals as an anti-flammatory agent
Interleukin-1 receptor
(IL1R) is an important
mediator involved in
many cytokine-induced
immune and inflammatory
processes. It is responsible
for transmission of signal
processes. It is responsible
for transmission of signal
transduction induced by
IL1a/IL1b, which activates a
number of genes including
inflammatory mediators
such as collagenase.
Transcripts of ILR1 are
down-regulated in fibroblast
exposed to oxidative
stress when pretreated with
easy algae plankton extract
(PM-E).
Inhibition of ILR1 expression under oxidative stress suggests
applications in skin disorders such as psoriasis or atopic dermatitis.
As a company our mission is, to
introduce the world to the benefits
of Phytoplankton and be the
trusted brand that always leads
with the heart first.
For more info please contact
23C York Street
Sackville, New Brunswick, Canada
E4L 4R3
Head Office 506 807-0239
FOR SKIN
POUR LA PEAU
DERMO COSMETIC