Angiotensin II Type 2 Receptor Antagonizes Angiotensin II
Type 1 Receptor–Mediated Cardiomyocyte Autophagy
by Enzo R. Porrello, Angelo D'Amore, Claire L. Curl, Andrew M. Allen, Stephen B.
Harrap, Walter G. Thomas, and Lea M.D. Delbridge
Hypertension
Volume 53(6):1032-1040
June 1, 2009
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. AT1 and AT2 receptor–mediated neonatal cardiomyocyte growth responses.
Enzo R. Porrello et al. Hypertension. 2009;53:1032-1040
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Autophagic response to AT1 and AT2 receptor expression in neonatal cardiomyocytes.
Enzo R. Porrello et al. Hypertension. 2009;53:1032-1040
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. Neonatal Ad-AT1A-infected NHR and HHR cardiomyocyte growth responses in absence
and presence (striped bars) of Ang II. A, Hypertrophy quantified as protein:DNA ratio expressed
as percentage change (mean±SEM) of the uninfected strain control (reference: 100%).
Enzo R. Porrello et al. Hypertension. 2009;53:1032-1040
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. Autophagic responses to stress in neonatal and adult NHRs and HHRs. A, Ad-AT1A–
infected neonatal NHR and HHR cardiomyocytes stimulated with 0.1 μmol/L of Ang II. GFPexpressing cells were visualized by fluorescence microscopy at low magnification.
Enzo R. Porrello et al. Hypertension. 2009;53:1032-1040
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. Hypertrophic and autophagic responses of NHR and HHR neonatal cardiomyocytes to
a high AT2:AT1 receptor expression ratio.
Enzo R. Porrello et al. Hypertension. 2009;53:1032-1040
Copyright © American Heart Association, Inc. All rights reserved.
Figure 6. Neonatal ventricular AT1 and AT2 receptor expression levels.
Enzo R. Porrello et al. Hypertension. 2009;53:1032-1040
Copyright © American Heart Association, Inc. All rights reserved.