Evaluation of CD4-CD4i antibody architectures yields potent, broadly cross-reactive anti-HIV reagents Anthony P. West, Jr., Rachel P. Galimidi, Christopher P. Foglesong, Priyanthi N. P. Gnanapragasam, Joshua S. Klein, Pamela J. Bjorkman Supplementary Tables 1-2 Supplementary Figure 1 Supplementary Table 1. Summary of Reagents Reagent IgG scFv CD4-scFv Antibody Linker(s) Construct name Yield mg/L E51 N/A E51 IgG 50 mg/L m9 N/A m9 IgG 20 mg/L 21c N/A 21c IgG 150 mg/L anti-gD N/A anti-gD IgG 8 mg/L 2G12 monomer N/A 2G12 monomer 3-4 mg/L Table 4 2G12 dimer N/A 2G12 dimer 0.3 mg/L Table 4 E51 GS3 scFvE51 10 mg/L Table 1 m9 GS3 scFvm9 10 mg/L 21c GS3 scFv21c 10 mg/L 17b GS7 CD4-scFv17b 1 mg/L E51 GS7 CD4-scFvE51 10 mg/L m9 GS7 CD4-scFvm9 3 mg/L Table 1 21c GS7 CD4-scFv21c 7-10 mg/L Table 1 17b GS7, IgG hinge CD4-scFv17b-Fc 0.2 mg/L Text CD4-scFv-Fc 1 IC50 Table Table 1 Table 1, 2 Reagent CD4HC-IgG Antibody Linker(s) Construct name E51 GS7 E51 GS9 17b GS7 m9 GS7 412d GS7 anti-gD GS7 2G12 monomer GS7 2G12 dimer GS7 CD4HC-(GS7)IgG2G12dim 0.3 mg/L Table 4 E51 GS7 CD4LC-(GS7)IgGE51 3 mg/L Table 2 E51 GS7, GS7 CD4HC,LC-(GS7)IgGE51 0.5 mg/L Table 2 CD4HC-(GS7)IgGE51 CD4HC-(GS9)IgGE51 CD4HC-(GS7)IgG17b CD4HC-(GS7)-IgGm9 CD4HC-(GS7)IgG412d CD4HC-(GS7)IgGanti-gD CD4HC-(GS7)IgG2G12mon Yield mg/L 10 mg/L 3 mg/L 1-2 mg/L 7 mg/L 10 mg/L 8 mg/L 3-4 mg/L IC50 Table Table 2,3 Table 3 Table 3 Table 3 Table 3 Table 3 Table2 4&5 CD4LC-IgG CD4HC,LC-IgG 2 Reagent Antibody Linker(s) Construct name Yield mg/L IC50 Table N/A GS7 CD4-Fc 4 mg/L Table 3 N/A N/A CD4-IgG2 N/A Table 3 CD4-Fc CD4-IgG2 (PRO 542) N/A = Not Applicable 3 Supplementary Table 2. Comparison of IC50 values (g/mL) for constructs reported here and commonly studied broadly neutralizing anti-HIV Abs. IC50 values for 4E10, b12, 2G12 and 2F5 Abs were taken from (18, 19) or provided by the CAVD neutralization core. PG9 and PG16 were tested on a larger panel of viruses (35), but only those that overlapped with our panel are reported in this table. Over a 162-pseudovirus panel, PG9 and PG16 had geometric mean IC50s of 0.86 and 0.83 g/mL, respectively. In calculating average IC50 values, measurements outside of the range of the assay (indicated by a “>” or “<” symbol) were assigned to that limiting value. ND = not determined. 4 Supplementary Figure 1. DNA and amino acid sequences of constructs. DNA sequences are in black, and amino acid sequences are in gray CD4-scFv17b ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTGGCGCTCCT CCCAGCAGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACT GACCTGTACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAA AGATTCTGGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCT GACTCAAGAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGAT AGAAGACTCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTA GTGTTCGGATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGA CCTTGGAGAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAA CATACAGGGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGG ACATGCACTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAG CTTTCCAGAAGGCCTCCGGAGGTGGCGGTAGTGGGGGAGGCGGTTCAGGCGGAGGTGGAT CCGGTGGCGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGAGGCGGAGG TTCACAGGTGCAGCTGCTCGAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAA GGTCTCCTGCAAGGCCTCTGGAGACACCTTCATCAGATATAGTTTTACCTGGGTGCGACAGG CCCCTGGACAAGGCCTTGAGTGGATGGGAAGGATCATCACTATCCTTGATGTAGCACACTAC GCACCGCACCTCCAGGGCAGAGTCACGATTACCGCGGACAAGTCCACGAGCACAGTCTACC TGGAGCTGCGGAATCTAAGATCTGACGATACGGCCGTATATTTCTGTGCGGGAGTGTACGA GGGAGAGGCGGACGAGGGGGAATATGATAATAATGGGTTTCTGAAACATTGGGGCCAGGG AACCCTGGTCACGGTCACCTCAGGTGGCGGTGGCTCCGGAGGTGGTGGGAGCGGTGGCGG CGGATCTGAACTCGAGTTGACGCAGTCTCCAGCCACCCTGTCTGTGTCTCCAGGGGAAAGA GCCACCCTCTCCTGCAGGGCCAGTGAGAGTGTTAGTAGCGACTTAGCCTGGTACCAGCAGA AACCTGGCCAGGCTCCCAGGCTCCTCATATATGGTGCATCCACCAGGGCCACCGGTGTCCC AGCCAGGTTCAGTGGCAGTGGGTCTGGGGCAGAATTCACTCTCACCATCAGCAGCCTGCAG TCTGAAGATTTTGCAGTTTATTACTGTCAGCAGTACAATAACTGGCCTCCGAGGTACACTTTT GGCCAGGGGACCAGGCTGGAGATCAAACTGGTGCCGCGCGGCAGCGGCCATCATCATCAT CATCATTGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSQVQLLESGAEVKKPGSSVKVSCKASGDTFIRY SFTWVRQAPGQGLEWMGRIITILDVAHYAPHLQGRVTITADKSTSTVYLELRNLR SDDTAVYFCAGVYEGEADEGEYDNNGFLKHWGQGTLVTVTSGGGGSGGGGSGGGG SELELTQSPATLSVSPGERATLSCRASESVSSDLAWYQQKPGQAPRLLIYGASTR ATGVPARFSGSGSGAEFTLTISSLQSEDFAVYYCQQYNNWPPRYTFGQGTRLEIK LVPRGSGHHHHHH________________________________________________________ CD4-scFvE51 ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTTTAATTAAAGGTGTCCAGTGTAAGAA AGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGTACAGCTTCCCAGAAGAAG AGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCTGGGAAATCAGGGCTCCTT CTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAAGAAGAAGCCTTTGGGACC AAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGACTCAGATACTTACATCTGTG AAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCGGATTGACTGCCAACTCTGA CACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGAGAGCCCCCCTGGTAGTAGC 5 CCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAGGGGGGGAAGACCCTCTCCG TGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCACTGTCTTGCAGAACCAGAA GAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAGAAGGCCTCCGGAGGTGGC GGTAGTGGGGGAGGCGGTTCAGGCGGAGGTGGATCCGGTGGCGGAGGGTCGGGCGGGG GTGGAAGCGGGGGTGGCGGCTCCGGAGGCGGAGGTTCAGAGGTGCAGCTGGTGCAGTCT GGGGCTGAGGTGAACAAGCCTGGGTCCTCGGTGAAGGTCTCCTGTCAGGCTTCTGGAGCCA CCTTAAACAGTCATGCTTTCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGAT GGCAGGGATCATCCCTATATTTGGTTCATCACACTACGCACAAAAGTTCCAGGGCAGAGTCA CGATTACCGCGGACGAGTCCACGCGCACAGTGTATTTGCATCTGAGAGGCCTGAGATCTGA TGACACGGCCGTTTATTACTGTGCGAGTAATTCTATTGCCGGAGTAGCAGCTGCCGGAGACT ACGCTGACTACGATGGGGGCTACTACTACGATATGGATGTCTGGGGCCAAGGGACCACGGT CACCGTCTCCTCAGGTGGCGGTGGCTCCGGAGGTGGTGGGAGCGGTGGCGGCGGATCTCA GTCTGTGTTGACGCAGCCGCCCTCAGTGTCTGCGGCCCCAGGACAGAAGGTCACCATCTCC TGCTCTGGAAGCAGCTCCAACATTGGGAATAATGATGTTTCCTGGTACCAGCAGTTCCCAGG AACAGTCCCCAAACTCGTCATCTATGAAAATAATCAGCGACCCTCAGGGATTCCTGACCGCT TCTCTGGCTCCAAGTCTGGCACGTCAGCCACCCTGGGCATCACCGGACTCCAGACTGGGGA CGAGGCCGATTATTACTGCGGCACATGGGATAGCAGCCTGAGTGCTGTGGTCTTCGGCGGA GGGTCCAAGGTGACCGTCCTAGGTTCGGCCGGCCACGGCCATCATCACCATCACCACTGA MEFWLSWVFLVALIKGVQCKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKI LGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKE EVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSV SQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGGGGSGGG GSGGGGSGGGGSGGGGSEVQLVQSGAEVNKPGSSVKVSCQASGATLNSHAFSWVR QAPGQGLEWMAGIIPIFGSSHYAQKFQGRVTITADESTRTVYLHLRGLRSDDTAV YYCASNSIAGVAAAGDYADYDGGYYYDMDVWGQGTTVTVSSGGGGSGGGGSGGGG SQSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNDVSWYQQFPGTVPKLVIYENNQ RPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGSKVTV LGSAGHGHHHHHH________________________________________________________ CD4-scFvm9 ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTTTAATTAAAGGTGTCCAGTGTAAGAA AGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGTACAGCTTCCCAGAAGAAG AGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCTGGGAAATCAGGGCTCCTT CTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAAGAAGAAGCCTTTGGGACC AAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGACTCAGATACTTACATCTGTG AAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCGGATTGACTGCCAACTCTGA CACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGAGAGCCCCCCTGGTAGTAGC CCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAGGGGGGGAAGACCCTCTCCG TGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCACTGTCTTGCAGAACCAGAA GAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAGAAGGCCTCCGGAGGTGGC GGTAGTGGGGGAGGCGGTTCAGGCGGAGGTGGATCCGGTGGCGGAGGGTCGGGCGGGG GTGGAAGCGGGGGTGGCGGCTCCGGAGGCGGAGGTTCAGAGGTGCAGCTGCTCGAGCAG TCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGCAGGTCTCCTGCAAGGCCTCTGGA GGCACCTTCAGCATGTATGGTTTCAACTGGGTGCGACAGGCCCCTGGACATGGCCTTGAGT GGATGGGAGGGATCATCCCTATCTTTGGTACAACAAACTACGCACAGAAGTTCCGGGGCAG AGTCACGTTTACCGCGGACCAAGCCACGAGCACAGCCTACATGGAGCTGACCAACCTGCGA TCTGACGACACGGCCGTCTATTATTGTGCGAGAGATTTTGGCCCCGACTGGGAAGGCGGTG ATTCCTATGATGGTAGTGGCCGGGGGTTCTTTGACTTCTGGGGCCAGGGAACCCTGGTCAA 6 CGTCTCCTCTGGTGGCGGTGGCTCCGGAGGTGGTGGGAGCGGTGGCGGCGGATCTGAAAT TGTGTTGACACAGTCTCCAGGCACCCTGTCTTTGTCTGCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTGTTAGCAGCGGCTCCTTAGCCTGGTACCAGCAGAAACCTGGTCA GGCTCCCAGGCTCCTCATCTACGGTGCATCCACCAGGGCCACTGGCATCCCAGACAGGTTC AGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACAATCGGCAGACTGGAGCCTGAAGATC TCGCAGTATATTACTGTCAGCAGTATGGTACCTCACCGTACACTTTTGGCCAGGGGACCAAA CTGGAGATCAAATCGGCCGGCCACGGCCATCATCACCATCACCACTGA MEFWLSWVFLVALIKGVQCKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKI LGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKE EVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSV SQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGGGGSGGG GSGGGGSGGGGSGGGGSEVQLLEQSGAEVKKPGSSVQVSCKASGGTFSMYGFNWV RQAPGHGLEWMGGIIPIFGTTNYAQKFRGRVTFTADQATSTAYMELTNLRSDDTA VYYCARDFGPDWEGGDSYDGSGRGFFDFWGQGTLVNVSSGGGGSGGGGSGGGGSE IVLTQSPGTLSLSAGERATLSCRASQSVSSGSLAWYQQKPGQAPRLLIYGASTRA TGIPDRFSGSGSGTDFTLTIGRLEPEDLAVYYCQQYGTSPYTFGQGTKLEIKSAG HGHHHHHH________________________________________________________ CD4-scFv21c ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGAGGCGGTTCAGGCGGAGGTGGATCCGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGAGGCGGAGGTTCACAG GTCCAGGTGGTACAGTCTGGGGCTGAGGTGAGGAAGCCTGGGGCCTCAGTGAAGGTCTCC TGCAAGGTTTCTGGATTCACCCTCACTGGATTATCCATACATTGGGTGCGACAGGCTCCTGG AAAAGGCCTTGAGTGGATGGGAGGTTTTGGTCCTGAGGAGAATGAAATAATCTACGCACAG AAGTTCCAGGGCAGAGTCTCCATGACCGAGGACACATCTACAAACACAGCCTACATGGAACT GAGTAGCCTCAGATCTGAGGACACGGCCGTCTATTACTGTGCAACGGGAGGCAACTATTAC AATTTGTGGACTGGTTATTATCCCCTTGCCTATTGGGGACAGGGAACCCAGGTCACCGTCTC CTCAGGTGGCGGTGGCTCCGGAGGTGGTGGGAGCGGTGGCGGCGGATCTCAGTCTGTGTT GACGCAGCCGCCCTCAGTGTCTGCGGCCCCAGGACAGAAGGTCACCATCTCCTGCTCTGGA AGCAGCTCCAACATTGGTAAAAATTATGTATCCTGGTACCAACAACTCCCAGGAGCAGCCCC CAAACTCCTCATTTTTGACGATACTCAGCGACCCTCAGGGATTCCTGACCGATTCTCTGGCTC CAAGTCTGGCACGTCAGCCACCCTGGCCATCACCGGACTCCAGACTGGGGACGAGGCCGAT TATTACTGCGGAACATGGGACAGCAGCCTGAGTACTGGCCAGCTCTTCGGCGGAGGGACCA AGCTGACCGTCCTAGGTCTGGTGCCGCGCGGCAGCGGCCATCATCATCATCATCATTGATG A MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN 7 SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSQVQVVQSGAEVRKPGASVKVSCKVSGFTLTGL SIHWVRQAPGKGLEWMGGFGPEENEIIYAQKFQGRVSMTEDTSTNTAYMELSSLR SEDTAVYYCATGGNYYNLWTGYYPLAYWGQGTQVTVSSGGGGSGGGGSGGGGSQS VLTQPPSVSAAPGQKVTISCSGSSSNIGKNYVSWYQQLPGAAPKLLIFDDTQRPS GIPDRFSGSKSGTSATLAITGLQTGDEADYYCGTWDSSLSTGQLFGGGTKLTVLG LVPRGSGHHHHHH-________________________________________________________ CD4-scFv17b-Fc ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGAGGCGGTTCAGGCGGAGGTGGATCCGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGAGGCGGAGGTTCACAG GTGCAGCTGCTCGAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCT GCAAGGCCTCTGGAGACACCTTCATCAGATATAGTTTTACCTGGGTGCGACAGGCCCCTGG ACAAGGCCTTGAGTGGATGGGAAGGATCATCACTATCCTTGATGTAGCACACTACGCACCG CACCTCCAGGGCAGAGTCACGATTACCGCGGACAAGTCCACGAGCACAGTCTACCTGGAGC TGCGGAATCTAAGATCTGACGATACGGCCGTATATTTCTGTGCGGGAGTGTACGAGGGAGA GGCGGACGAGGGGGAATATGATAATAATGGGTTTCTGAAACATTGGGGCCAGGGAACCCTG GTCACGGTCACCTCAGGTGGCGGTGGCTCCGGAGGTGGTGGGAGCGGTGGCGGCGGATCT GAACTCGAGTTGACGCAGTCTCCAGCCACCCTGTCTGTGTCTCCAGGGGAAAGAGCCACCC TCTCCTGCAGGGCCAGTGAGAGTGTTAGTAGCGACTTAGCCTGGTACCAGCAGAAACCTGG CCAGGCTCCCAGGCTCCTCATATATGGTGCATCCACCAGGGCCACCGGTGTCCCAGCCAGG TTCAGTGGCAGTGGGTCTGGGGCAGAGTTCACTCTCACCATCAGCAGCCTGCAGTCTGAAG ATTTTGCAGTTTATTACTGTCAGCAGTACAATAACTGGCCTCCGAGGTACACTTTTGGCCAG GGGACCAGGCTGGAGATCAAATCGGCCGGCCACGGCGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCC CCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGC ATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAA CAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAA CCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGA CCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCA GCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCT ACAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGT GATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAAT GA 8 MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSQVQLLESGAEVKKPGSSVKVSCKASGDTFIRY SFTWVRQAPGQGLEWMGRIITILDVAHYAPHLQGRVTITADKSTSTVYLELRNLR SDDTAVYFCAGVYEGEADEGEYDNNGFLKHWGQGTLVTVTSGGGGSGGGGSGGGG SELELTQSPATLSVSPGERATLSCRASESVSSDLAWYQQKPGQAPRLLIYGASTR ATGVPARFSGSGSGAEFTLTISSLQSEDFAVYYCQQYNNWPPRYTFGQGTRLEIK SAGHGEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYK CKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKSLSLSPGK________________________________________________________ CD4HC-(GS7)-IgG17b Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGAGGCGGTTCAGGCGGAGGTGGATCCGGTGG CGGCTCCGGAGGCGGAGGTTCACAGGTGCAGCTGCTCGAGTCTGGGGCTGAGGTGAAGAA GCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCCTCTGGAGACACCTTCATCAGATATAGTT TTACCTGGGTGCGACAGGCCCCTGGACAAGGCCTTGAGTGGATGGGAAGGATCATCACTAT CCTTGATGTAGCACACTACGCACCGCACCTCCAGGGCAGAGTCACGATTACCGCGGACAAG TCCACGAGCACAGTCTACCTGGAGCTGCGGAATCTAAGATCTGACGATACGGCCGTATATTT CTGTGCGGGAGTGTACGAGGGAGAGGCGGACGAGGGGGAATATGATAATAATGGGTTTCT GAAACATTGGGGCCAGGGAACCCTGGTCACGGTCACCTCAGCTTCCACCAAGGGCCCATCG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCC TGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAG CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTG GTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGC CCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACGTG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAAC CCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAG CCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCCTCACC GTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCACAGGT 9 GTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTG GTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAG AACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAA GCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGSGGGGSQVQLLESGAEVKKPGSSVKVSCKASGDTFIRYSFTWVRQAPGQ GLEWMGRIITILDVAHYAPHLQGRVTITADKSTSTVYLELRNLRSDDTAVYFCAG VYEGEADEGEYDNNGFLKHWGQGTLVTVTSASTKGPSVFPLAPSSKSTSGGTAAL GCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT YICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLM ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRW QQGNVFSCSVMHEALHNHYTQKSLSLSPGK17b Light Chain ATGGAAACCCCAGCGCAGCTTCTCTTCCTCCTGCTACTCTGGCTCCCAGATACCACCGGAGA ACTCGAGTTGACGCAGTCTCCAGCCACCCTGTCTGTGTCTCCAGGGGAAAGAGCCACCCTC TCCTGCAGGGCCAGTGAGAGTGTTAGTAGCGACTTAGCCTGGTACCAGCAGAAACCTGGCC AGGCTCCCAGGCTCCTCATATATGGTGCATCCACCAGGGCCACCGGTGTCCCAGCCAGGTT CAGTGGCAGTGGGTCTGGGGCAGAGTTCACTCTCACCATCAGCAGCCTGCAGTCTGAAGAT TTTGCAGTTTATTACTGTCAGCAGTACAATAACTGGCCTCCGAGGTACACTTTTGGCCAGGG GACCAGGCTGGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTG ATGAGCAGTTGAAATCTGGGACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGA GAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTG TCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAA AGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCG CCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA METPAQLLFLLLLWLPDTTGELELTQSPATLSVSPGERATLSCRASESVSSDLAW YQQKPGQAPRLLIYGASTRATGVPARFSGSGSGAEFTLTISSLQSEDFAVYYCQQ YNNWPPRYTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGEC________________________________________________________ CD4HC-(GS7)-IgGE51 Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG 10 GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCGAG GTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAACAAGCCTGGGTCCTCGGTGAAGGTCTCCT GTCAGGCTTCTGGAGCCACCTTAAACAGTCATGCTTTCAGCTGGGTGCGACAGGCCCCTGG ACAAGGGCTTGAGTGGATGGCAGGGATCATCCCTATATTTGGTTCATCACACTACGCACAAA AGTTCCAGGGCAGAGTCACGATTACCGCGGACGAGTCCACGCGCACAGTGTATTTGCATCT GAGAGGCCTGAGATCTGATGACACGGCCGTTTATTACTGTGCGAGTAATTCTATTGCCGGAG TAGCAGCTGCCGGAGACTACGCTGACTACGATGGGGGCTACTACTACGATATGGATGTCTG GGGCCAAGGGACCACGGTCACCGTCTCCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCCC CTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAG GACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGC ACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTG CCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACA CCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACGTGCCCACCGTG CCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGA CCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAG CCGCGGGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCCTCACCGTCCTGCAC CAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCACAGGTGTACACCCT GCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAAGCTCACCGTG GACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGC ACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSEVQLVQSGAEVNKPGSSVKVSCQASGATLNSH AFSWVRQAPGQGLEWMAGIIPIFGSSHYAQKFQGRVTITADESTRTVYLHLRGLR SDDTAVYYCASNSIAGVAAAGDYADYDGGYYYDMDVWGQGTTVTVSSASTKGPSV FPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTK PREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKE51 Light Chain ATGACCTGCTCCCCTCTCCTCCTCACCCTTCTCATTCACTGCACAGGGTCCTGGGCCCAGTC TGTGTTGACGCAGCCGCCCTCAGTGTCTGCGGCCCCAGGACAGAAGGTCACCATCTCCTGC TCTGGAAGCAGCTCCAACATTGGGAATAATGATGTTTCCTGGTACCAGCAGTTCCCAGGAAC AGTCCCCAAACTCGTCATCTATGAAAATAATCAGCGACCCTCAGGGATTCCTGACCGCTTCT CTGGCTCCAAGTCTGGCACGTCAGCCACCCTGGGCATCACCGGACTCCAGACTGGGGACGA GGCCGATTATTACTGCGGCACATGGGATAGCAGCCTGAGTGCTGTGGTCTTCGGCGGAGGG 11 TCCAAGGTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCGCCCTC CTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGG GAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCA CCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCC TGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGT GGAGAAGACAGTGGCCCCTACAGAATGTTCATGA METPAQLLFLLLLWLPDTTGELELTQSPATLSVSPGERATLSCRASESVSSDLAW YQQKPGQAPRLLIYGASTRATGVPARFSGSGSGAEFTLTISSLQSEDFAVYYCQQ YNNWPPRYTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGEC________________________________________________________ CD4HC-(GS9)-IgGE51 Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGTGGCTCCGGA GGTGGTGGGTCCGGTGGCGGAGGATCCGAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGT GAACAAGCCTGGGTCCTCGGTGAAGGTCTCCTGTCAGGCTTCTGGAGCCACCTTAAACAGT CATGCTTTCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGCAGGGATC ATCCCTATATTTGGTTCATCACACTACGCACAAAAGTTCCAGGGCAGAGTCACGATTACCGC GGACGAGTCCACGCGCACAGTGTATTTGCATCTGAGAGGCCTGAGATCTGATGACACGGCC GTTTATTACTGTGCGAGTAATTCTATTGCCGGAGTAGCAGCTGCCGGAGACTACGCTGACTA CGATGGGGGCTACTACTACGATATGGATGTCTGGGGCCAAGGGACCACGGTCACCGTCTCC TCAGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGG GGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTC GTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCA GGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCT ACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAA ATCTTGTGACAAAACTCACACGTGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGT CACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACG TACCGGGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAA GGTCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGA ACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGA CGGCTCCTTCTTCCTCTACAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAAC GTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTC CCTGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN 12 SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSEVQLVQSGAEVNKPGSSVKVSC QASGATLNSHAFSWVRQAPGQGLEWMAGIIPIFGSSHYAQKFQGRVTITADESTR TVYLHLRGLRSDDTAVYYCASNSIAGVAAAGDYADYDGGYYYDMDVWGQGTTVTV SSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTF PAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENN YKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GKE51 Light Chain ATGACCTGCTCCCCTCTCCTCCTCACCCTTCTCATTCACTGCACAGGGTCCTGGGCCCAGTC TGTGTTGACGCAGCCGCCCTCAGTGTCTGCGGCCCCAGGACAGAAGGTCACCATCTCCTGC TCTGGAAGCAGCTCCAACATTGGGAATAATGATGTTTCCTGGTACCAGCAGTTCCCAGGAAC AGTCCCCAAACTCGTCATCTATGAAAATAATCAGCGACCCTCAGGGATTCCTGACCGCTTCT CTGGCTCCAAGTCTGGCACGTCAGCCACCCTGGGCATCACCGGACTCCAGACTGGGGACGA GGCCGATTATTACTGCGGCACATGGGATAGCAGCCTGAGTGCTGTGGTCTTCGGCGGAGGG TCCAAGGTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCGCCCTC CTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGG GAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCA CCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCC TGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGT GGAGAAGACAGTGGCCCCTACAGAATGTTCATGA METPAQLLFLLLLWLPDTTGELELTQSPATLSVSPGERATLSCRASESVSSDLAW YQQKPGQAPRLLIYGASTRATGVPARFSGSGSGAEFTLTISSLQSEDFAVYYCQQ YNNWPPRYTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECCD4HC-(GS7)-IgGm9 Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCGAG GTGCAGCTGCTCGAGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGCAGGTC TCCTGCAAGGCCTCTGGAGGCACCTTCAGCATGTATGGTTTCAACTGGGTGCGACAGGCCC 13 CTGGACATGGCCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAACAAACTACGCA CAGAAGTTCCGGGGCAGAGTCACGTTTACCGCGGACCAAGCCACGAGCACAGCCTACATGG AGCTGACCAACCTGCGATCTGACGACACGGCCGTCTATTATTGTGCGAGAGATTTTGGCCCC GACTGGGAAGGCGGTGATTCCTATGATGGTAGTGGCCGGGGGTTCTTTGACTTCTGGGGCC AGGGAACCCTGGTCAACGTCTCCTCTGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTAC TTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCT TCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCC AGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGG TGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACGTGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCAT GATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCG GGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCCTCACCGTCCTGCACCAGGAC TGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCG AGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTAT CCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACC ACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSEVQLLEQSGAEVKKPGSSVQVSCKASGGTFSM YGFNWVRQAPGHGLEWMGGIIPIFGTTNYAQKFRGRVTFTADQATSTAYMELTNL RSDDTAVYYCARDFGPDWEGGDSYDGSGRGFFDFWGQGTLVNVSSASTKGPSVFP LAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSL SSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGG PSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQ VYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDG SFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKM9 Light Chain ATGACCTGCTCCCCTCTCCTCCTCACCCTTCTCATTCACTGCACAGGGTCCTGGGCCGAAAT TGTGTTGACACAGTCTCCAGGCACCCTGTCTTTGTCTGCAGGGGAAAGAGCCACCCTCTCCT GCAGGGCCAGTCAGAGTGTTAGCAGCGGCTCCTTAGCCTGGTACCAGCAGAAACCTGGTCA GGCTCCCAGGCTCCTCATCTACGGTGCATCCACCAGGGCCACTGGCATCCCAGACAGGTTC AGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACAATCGGCAGACTGGAGCCTGAAGATC TCGCAGTATATTACTGTCAGCAGTATGGTACCTCACCGTACACTTTTGGCCAGGGGACCAAA CTGGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCA AAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGCGTCACAGA GCAGGACAGCAGGGACAGCACCTACAGCCTCGGAAGCACCCTGACGCTGAGCAAAGCAGA CTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGTTCGCCCGTC ACAAAGAGCTTCAACAGGGGAGAGTGTTGA MTCSPLLLTLLIHCTGSWAEIVLTQSPGTLSLSAGERATLSCRASQSVSSGSLAW 14 YQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTDFTLTIGRLEPEDLAVYYCQQ YGTSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAK VQWKVDNALQSGNSQESVTEQDSRDSTYSLGSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGEC________________________________________________________ CD4HC-(GS7)-IgG21c Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGaAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCCAG GTCCAGGTGGTACAGTCTGGGGCTGAGGTGAGGAAGCCTGGGGCCTCAGTGAAGGTCTCC TGCAAGGTTTCTGGATTCACCCTCACTGGATTATCCATACATTGGGTGCGACAGGCTCCTGG AAAAGGCCTTGAGTGGATGGGAGGTTTTGGTCCTGAGGAGAATGAAATAATCTACGCACAG AAGTTCCAGGGCAGAGTCTCCATGACCGAGGACACATCTACAAACACAGCCTACATGGAACT GAGTAGCCTCAGATCTGAGGACACGGCCGTCTATTACTGTGCAACGGGAGGCAACTATTAC AATTTGTGGACTGGTTATTATCCCCTTGCCTATTGGGGACAGGGAACCCTGGTCACCGTCTC CTCAGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTG GGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTcCCCGAACCGGTGACGGTGTC GTGGAACTCAGGCGCCcTGACCAGCGGCGTGCACACCTTCCCGGCTGTcCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTA CATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAA TCTTGTGACAAAACTCACACGTGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGT CAGtCTYCYTCttCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCA CATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGA CGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTA CCGGGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAG TGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGG TCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAAC CAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTACAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGT CTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCC TGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSQVQVVQSGAEVRKPGASVKVSCKVSGFTLTGL SIHWVRQAPGKGLEWMGGFGPEENEIIYAQKFQGRVSMTEDTSTNTAYMELSSLR 15 SEDTAVYYCATGGNYYNLWTGYYPLAYWGQGTLVTVSSASTKGPSVFPLAPSSKS TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVXXFP PKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNST YRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK21c Light Chain ATGACCTGCTCCCCTCTCCTCCTCACCCTTCTCATTCACTGCACAGGGTCCTGGGCCCAGTC TGTGTTGACGCAGCCGCCCTCAGTGTCTGCGGCCCCAGGACAGAAGGTCACCATCTCCTGC TCTGGAAGCAGCTCCAACATTGGTAAAAATTATGTATCCTGGTACCAACAACTCCCAGGAGC AGCCCCCAAACTCCTCATTTTTGACGATACTCAGCGACCCTCAGGGATTCCTGACCGATTCT CTGGCTCCAAGTCTGGCACGTCAGCCACCCTGGCCATCACCGGACTCCAGACTGGGGACGA GGCCGATTATTACTGCGGAACATGGGACAGCAGCCTGAGTACTGGCCAGCTCTTCGGCGGA GGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCGC CCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTAC CCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGA GACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTACCTGAGCCTG ACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGC ACCGTGGAGAAGACAATGGCCCATGCAGAATGTTCTTAG MTCSPLLLTLLIHCTGSWAQSVLTQPPSVSAAPGQKVTISCSGSSSNIGKNYVSW YQQLPGAAPKLLIFDDTQRPSGIPDRFSGSKSGTSATLAITGLQTGDEADYYCGT WDSSLSTGQLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYP GAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT HEGSTVEKTMAHAECS________________________________________________________ CD4HC-(GS7)-IgG412d Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCGAG GTGCAGCTGCTCGAGCAGTCTGGGGCTGAGGTGAAGAAACCTGGGTCCTCGGTGAAGGTC TCCTGCAAGGCTTCTGGAGGCACCTTCAGCAACTATGCTATCAACTGGGTGCGACAGGCCC CTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCCATCTTTAATATAGCACACTACGC ACAGAGATTCCAGGGCAGAGTCTCGATTACCGCGGACGAATCCACGAGCACAGCCTACATG GAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTATTTTACTGTGCGAGCCCTTACCCGA ATGACTACAATGACTACGCCCCAGAGGAGGGAATGAGCTGGTACTTCGATCTCTGGGGCCG GGGCACCCTGGTCACCGTCTCCCCAGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACT TCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTT 16 CCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCA GCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGT GGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACGTGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCAT GATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCG GGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCCTCACCGTCCTGCACCAGGAC TGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCG AGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTAT CCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACC ACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSEVQLLEQSGAEVKKPGSSVKVSCKASGGTFSN YAINWVRQAPGQGLEWMGGIIPIFNIAHYAQRFQGRVSITADESTSTAYMELSSL RSEDTAVFYCASPYPNDYNDYAPEEGMSWYFDLWGRGTLVTVSPASTKGPSVFPL APSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLS SVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPRE EQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGS FFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK412d Light Chain ATGACCTGCTCCCCTCTCCTCCTCACCCTTCTCATTCACTGCACAGGGTCCTGGGCCGAAAT TGTGTTGACACAGTCTCCAGGCACCCTGTCTTTGTCTGTAGGAGACAGAGTCACCATCACTT GTCGGGCCAGTCAGAGTATTAGTAACTGGTTGGCCTGGTATCAGCAGAAACCAGGGAGGGC CCCTAAGCTCCTGATGTATAAGGCGTCTAGTTTAAAAAGTGGGGTCCCATCAAGGTTCAGCG GCAGTGGATCTGGGACAGAGTTCACTCTCACCATCAGCAGCCTGCAGTCTGATGATTTTGCA ACTTATTACTGCCAACAGCATGATAGTTCCCCGTACACTTTTGGCCAGGGGACCAAGCTGGA GATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGA AATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG ACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGA GAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTGACAAAG AGCTTCAACAGGGGAGAGTGTTGA MTCSPLLLTLLIHCTGSWAEIVLTQSPGTLSLSVGDRVTITCRASQSISNWLAWY QQKPGRAPKLLMYKASSLKSGVPSRFSGSGSGTEFTLTISSLQSDDFATYYCQQH DSSPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKV QWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL SSPVTKSFNRGEC________________________________________________________ CD4HC-(GS7)-IgG2G12 Heavy Chain 17 ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCGAG GTGCAACTGcTCGAGTCTGGGGGAGGCCTGGTCAAGGCGGGAGGATCCCTCATACTCTCCT GTGGAGTATCTAATTTTAGAATCTCTGCCCATACCATGAATTGGGTCCGCCGGGTTCCAGGG GGGGGGCTGGAGTGGGTCGCTTCCATTAGTACGAGTTCCACTTATAGAGACTATGCAGACG CTGTGAAGGGCCGATTCACCGTTTCCAGAGACGACCTCGAAGACTTTGTGTATTTGCAAATG CACAAAATGAGAGTCGAAGACACGGCTATTTATTACTGCGCCAGAAAGGGATCTGACAGACT AAGCGACAACGATCCTTTTGATGCCTGGGGCCCAGGGACAGTGGTCACCGTCTCTCCAGCT TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCA CAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAA CTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTC TACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCT GCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTG TGACAAAActagtACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTT CCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCG TGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGT GGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGT GGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC CCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGT CAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGC AATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCT TCTTCCTCTACAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTC CGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVKAGGSLILSCGVSNFRISAH TMNWVRRVPGGGLEWVASISTSSTYRDYADAVKGRFTVSRDDLEDFVYLQMHKMR VEDTAIYYCARKGSDRLSDNDPFDAWGPGTVVTVSPASTKGPSVFPLAPSSKSTS GGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTSTCPPCPAPELLGGPSVFLFPPK PKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYR VVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK2G12 LC 18 ATGGAAACCCCAGCGCAGCTTCTCTTCCTCCTGCTACTCTGGCTCCCAGAAAGCACCGGAGA AATTGAGCTCACCCAGTCTCCTTCCACCCTGTCTGCATCTGTCGGAGACACAATCACCATCA CTTGCCGGGCCAGTCAGAGTATTGAAACCTGGTTGGCCTGGTATCAGCAGAAGCCAGGGAA AGCCCCAAAACTCCTAATCTACAAGGCGTCTACTTTAAAAACTGGAGTCCCGTCAAGATTCA GCGGCAGTGGATCTGGAACAGAGTTCACTCTTACCATCAGTGGCCTGCAGTTCGATGACTTT GCAACTTATCACTGTCAGCACTATGCTGGTTATTCAGCCACTTTTGGCCAGGGAACCAGGGT GGAGATCAAACGTACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGT TGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAA GTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGTTGAGCAAAGCAGACTA CGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCANGGCCTGAGTTCGCCCGTCACA AAGAGCTTCAACAGGGGAGAGTGTTAG METPAQLLFLLLLWLPESTGEIELTQSPSTLSASVGDTITITCRASQSIETWLAW YQQKPGKAPKLLIYKASTLKTGVPSRFSGSGSGTEFTLTISGLQFDDFATYHCQH YAGYSATFGQGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAK VQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHXG LSSPVTKSFNRGEC________________________________________________________ CD4HC-(GS7)-IgGanti-gD Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCGAG GTGCAACTGCTCGAGCAGGTGCAGCTGGTGCAGTCCGGCGCCGAGGTCAAGAAGCCCGGC TCGTCCGTGAAGGTCTCCTGCAAGGCCTCGGGCGGTTCCTTCTCGTCCTACGCTATCAACTG GGTGCGCCAGGCCCCCGGCCAGGGTCTGGAGTGGATGGGCGGCCTGATGCCCATCTTCGG CACCACTAACTACGCCCAGAAGTTCCAGGACCGCCTGACCATCACCGCTGACGTGTCCACCA GCACCGCCTACATGCAGCTGTCCGGCCTGACCTACGAGGACACCGCCATGTACTACTGCGC TCGCGTCGCCTACATGCTGGAGCCCACCGTGACCGCTGGCGGTCTGGACGTGTGGGGCAA GGGCACCACCGTCACCGTGAGCTCCGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACT TCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTT CCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCA GCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGT GGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACGTGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCAT GATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCG GGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCCTCACCGTCCTGCACCAGGAC TGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCG AGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCC 19 ATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTAT CCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACC ACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSEVQLLEQVQLVQSGAEVKKPGSSVKVSCKASG GSFSSYAINWVRQAPGQGLEWMGGLMPIFGTTNYAQKFQDRLTITADVSTSTAYM QLSGLTYEDTAMYYCARVAYMLEPTVTAGGLDVWGKGTTVTVSSASTKGPSVFPL APSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLS SVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPRE EQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGS FFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKAnti-gD Light Chain ATGAAATACCTATTGCCTACGGCAGCCGCTGGATTGTTATTACTCGCTGCCCA ACCAGCCATGGCCGAGCTCACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAG GGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGTAGCGCCTA CTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTAT GGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGT CTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAACCTGAAGATTTTGC AGTGTATTACTGTCAGCAGTATGGTAGGTCACCCACTTTCGGCGGAGGGACC AAGGTGGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCC ATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATA ACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCAC CTACAGCCTCAGCAACACCCTGACGCTGAGCAAAGCAGACTACGAGAAACA CAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGATCGCCCGTCACA AAGAGCTTCAACAGGGGAGAGTGTTAG MKYLLPTAAAGLLLLAAQPAMAELTQSPGTLSLSPGERATLSCRASQSVSSAYLA WYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQ QYGRSPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAK VQWKVDNALQSGNSQESVTEQDSKDSTYSLSNTLTLSKADYEKHKVYACEVTHQG LRSPVTKSFNRGEC________________________________________________________ CD4LC-(GS7)-IgGE51 E51 Heavy Chain ATGGACTGCACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCCACAGGCACCCACGCCGAGG TGCAGCTGGTGCAGTCTGGGGCTGAGGTGAACAAGCCTGGGTCCTCGGTGAAGGTCTCCTG TCAGGCTTCTGGAGCCACCTTAAACAGTCATGCTTTCAGCTGGGTGCGACAGGCCCCTGGA CAAGGGCTTGAGTGGATGGCAGGGATCATCCCTATATTTGGTTCATCACACTACGCACAAAA 20 GTTCCAGGGCAGAGTCACGATTACCGCGGACGAGTCCACGCGCACAGTGTATTTGCATCTG AGAGGCCTGAGATCTGATGACACGGCCGTTTATTACTGTGCGAGTAATTCTATTGCCGGAGT AGCAGCTGCCGGAGACTACGCTGACTACGATGGGGGCTACTACTACGATATGGATGTCTGG GGCCAAGGGACCACGGTCACCGTCTCCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCCCC TGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGG ACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCA CACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGC CCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACAC CAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACGTGCCCACCGTGC CCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGC CGCGGGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCCTCACCGTCCTGCACC AGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCACAGGTGTACACCCTG CCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCT TCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAA GACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAAGCTCACCGTGG ACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCA CAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA MDCTWRILFLVAAATGTHAEVQLVQSGAEVNKPGSSVKVSCQASGATLNSHAFSW VRQAPGQGLEWMAGIIPIFGSSHYAQKFQGRVTITADESTRTVYLHLRGLRSDDT AVYYCASNSIAGVAAAGDYADYDGGYYYDMDVWGQGTTVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSS VVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREE QYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVY TLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF FLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKCD4-E51-LC Light Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGGGCCCAG TCTGTGTTGACGCAGCCGCCCTCAGTGTCTGCGGCCCCAGGACAGAAGGTCACCATCTCCT GCTCTGGAAGCAGCTCCAACATTGGGAATAATGATGTTTCCTGGTACCAGCAGTTCCCAGGA ACAGTCCCCAAACTCGTCATCTATGAAAATAATCAGCGACCCTCAGGGATTCCTGACCGCTT CTCTGGCTCCAAGTCTGGCACGTCAGCCACCCTGGGCATCACCGGACTCCAGACTGGGGAC GAGGCCGATTATTACTGCGGCACATGGGATAGCAGCCTGAGTGCTGTGGTCTTCGGCGGAG GGTCCAAGGTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCGCC CTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAG 21 ACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGA CGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCA CCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGA MTSTLPFSPQVSTPRSKFKRISSEFAATMNRGVPFRHLLLVLQLALLPAATQGKK VVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADS RRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQ SLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKK VEFKIDIVVLAFQKASGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGAQSVL TQPPSVSAAPGQKVTISCSGSSSNIGNNDVSWYQQFPGTVPKLVIYENNQRPSGI PDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGSKVTVLGQPK AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPS KQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS________________________________________________________ CD4HC,LC-(GS7)-IgGE51 Heavy Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCGAG GTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAACAAGCCTGGGTCCTCGGTGAAGGTCTCCT GTCAGGCTTCTGGAGCCACCTTAAACAGTCATGCTTTCAGCTGGGTGCGACAGGCCCCTGG ACAAGGGCTTGAGTGGATGGCAGGGATCATCCCTATATTTGGTTCATCACACTACGCACAAA AGTTCCAGGGCAGAGTCACGATTACCGCGGACGAGTCCACGCGCACAGTGTATTTGCATCT GAGAGGCCTGAGATCTGATGACACGGCCGTTTATTACTGTGCGAGTAATTCTATTGCCGGAG TAGCAGCTGCCGGAGACTACGCTGACTACGATGGGGGCTACTACTACGATATGGATGTCTG GGGCCAAGGGACCACGGTCACCGTCTCCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCCC CTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAG GACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGC ACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTG CCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACA CCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACGTGCCCACCGTG CCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGA CCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAG CCGCGGGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCCTCACCGTCCTGCAC CAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCACAGGTGTACACCCT GCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAAGCTCACCGTG GACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGC ACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA 22 MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG GGSGGGGSGGGGSGGGGSGGGGSEVQLVQSGAEVNKPGSSVKVSCQASGATLNSH AFSWVRQAPGQGLEWMAGIIPIFGSSHYAQKFQGRVTITADESTRTVYLHLRGLR SDDTAVYYCASNSIAGVAAAGDYADYDGGYYYDMDVWGQGTTVTVSSASTKGPSV FPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTK PREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKCD4-E51-LC Light Chain ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGGGCCCAG TCTGTGTTGACGCAGCCGCCCTCAGTGTCTGCGGCCCCAGGACAGAAGGTCACCATCTCCT GCTCTGGAAGCAGCTCCAACATTGGGAATAATGATGTTTCCTGGTACCAGCAGTTCCCAGGA ACAGTCCCCAAACTCGTCATCTATGAAAATAATCAGCGACCCTCAGGGATTCCTGACCGCTT CTCTGGCTCCAAGTCTGGCACGTCAGCCACCCTGGGCATCACCGGACTCCAGACTGGGGAC GAGGCCGATTATTACTGCGGCACATGGGATAGCAGCCTGAGTGCTGTGGTCTTCGGCGGAG GGTCCAAGGTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCGCC CTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAG ACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGA CGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCA CCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGA MTSTLPFSPQVSTPRSKFKRISSEFAATMNRGVPFRHLLLVLQLALLPAATQGKK VVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADS RRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQ SLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKK VEFKIDIVVLAFQKASGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGAQSVL TQPPSVSAAPGQKVTISCSGSSSNIGNNDVSWYQQFPGTVPKLVIYENNQRPSGI PDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGSKVTVLGQPK 23 AAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPS KQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS________________________________________________________ CD4 D1-D2 ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTGGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCATCGACGGAAGGCATCATCATCATCATCATTGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKAIDGRHHHHHH________________________________________________________ CD4-Fc ATGAACCGGGGAGTCCCTTTTAGGCACTTGCTTCTGGTGCTGCAACTAGCGCTCCTCCCAGC AGCCACTCAGGGAAAGAAAGTGGTGCTGGGCAAAAAAGGGGATACAGTGGAACTGACCTGT ACAGCTTCCCAGAAGAAGAGCATACAATTCCACTGGAAAAACTCCAACCAGATAAAGATTCT GGGAAATCAGGGCTCCTTCTTAACTAAAGGTCCATCCAAGCTGAATGATCGCGCTGACTCAA GAAGAAGCCTTTGGGACCAAGGAAACTTCCCCCTGATCATCAAGAATCTTAAGATAGAAGAC TCAGATACTTACATCTGTGAAGTGGAGGACCAGAAGGAGGAGGTGCAATTGCTAGTGTTCG GATTGACTGCCAACTCTGACACCCACCTGCTTCAGGGGCAGAGCCTGACCCTGACCTTGGA GAGCCCCCCTGGTAGTAGCCCCTCAGTGCAATGTAGGAGTCCAAGGGGTAAAAACATACAG GGGGGGAAGACCCTCTCCGTGTCTCAGCTGGAGCTCCAGGATAGTGGCACCTGGACATGCA CTGTCTTGCAGAACCAGAAGAAGGTGGAGTTCAAAATAGACATCGTGGTGCTAGCTTTCCAG AAGGCCTCCGGAGGTGGCGGTAGTGGGGGTGGCGGTTCAGGCGGAGGTGGATCGGGTGG CGGAGGGTCGGGCGGGGGTGGAAGCGGGGGTGGCGGCTCCGGTGGCGGAGGATCCCTCA CGTGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCC AAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATA ATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGGGTGGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAA AGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGTCAGCCCCGAGAACCA CAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCT GCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGC CGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAC AGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGA TGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKN SNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICE VEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQG GKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASGGGGSGGGGSGG 24 GGSGGGGSGGGGSGGGGSGGGGSLTCPPCPAPELLGGPSVFLFPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLH QDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSL TCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG NVFSCSVMHEALHNHYTQKSLSLSPGK- 25
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