Additional file 2, Table S1. List of observed membrane and membrane- associated proteins from M. tuberculosis H37Rv.
Sanger
Gene
protein description
Functional Lipoprotein
ID
name
category
/OMP
Rv3156
Rv3910
Rv3158
Rv3157
Rv1410c
Rv2846c
Rv3792
Rv3794
Rv3793
Rv2320c
Rv1737c
Rv2174
Rv2508c
Rv1217c
Rv0346c
Rv2127
Rv3043c
Rv0537c
Rv2942
Rv0676c
Rv3795
Rv0402c
Rv0290
Rv1302
nuoL
nuoN
nuoM
P55
efpA
embA
embC
rocE
narK2
mptA
ansP2
ansP1
ctaD
mmpL7
mmpL5
embB
mmpL1
rfe
Possible NADH dehydrogenase
Possible conserved transmembrane protein
Possible NADH dehydrogenase
Possible NADH dehydrogenase
Aminoglycosides/tetracycline-transport integral membrane protein
Possible integral membrane efflux protein
Possible conserved transmembrane protein
Integral membrane indolylacetylinositol arabinosyltransferase
Integral membrane indolylacetylinositol arabinosyltransferase
Possible cationic amino acid transport integral membrane protein
Possible nitrate/nitrite transporter
Alpha(1->6)mannosyltransferase
Possible conserved integral membrane leucine and alanine rich protein
Possible tetronasin-transport integral membrane protein abc transporter
Possible l-asparagine permease
Possible l-asparagine permease
Possible cytochrome c oxidase polypeptide
Possible integral membrane protein
Conserved transmembrane transport protein
Possible conserved transmembrane transport protein
Integral membrane indolylacetylinositol arabinosyltransferase
Possible conserved transmembrane transport protein
Possible conserved transmembrane protein
Possible undecapaprenyl-phosphate alpha-nacetylglucosaminyltransferase
1
7
3
7
7
3
3
3
3
3
3
3
3
3
3
3
3
7
3
3
3
3
3
3
3
-
No. References
of
TMH
16
15
[1-3]
14
[1, 3-6]
14
[5]
14
[1, 5]
14
13
[2]
13
[1, 2, 5]
13
[2, 5]
12
12
[3]
12
12
12
12
12
[5]
12
[1, 5, 6]
12
12
[1]
12
[1, 2]
12
[2, 5]
12
[2, 4]
11
[1-3, 5]
11
[2]
Rv0037c
Rv2920c
Rv1707
Rv3877
Rv3476c
Rv1183
Rv0450c
Rv0206c
Rv3236c
Rv1795
Rv2181
Rv1254
Rv0226c
Rv1459c
Rv0143c
Rv2387
Rv1508c
Rv3273
Rv2963
Rv0732
Rv2723
Rv3152
Rv1623c
Rv0908
Rv2196
Rv0205
Rv0935
Rv1101c
amt
kgtP
mmpL10
mmpL4
mmpL3
kefB
secY
nuoH
cydA
ctpE
qcrB
pstC1
-
Possible conserved integral membrane protein
Possible ammonium-transport integral membrane protein
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Possible dicarboxylic acid transport integral membrane protein
Possible conserved transmembrane transport protein
Possible conserved transmembrane transport protein
Possible conserved transmembrane transport protein
Possible conserved integral membrane transport protein
Conserved hypothetical membrane protein
Possible alpha(1->2)mannosyltransferase
Possible acyltransferase
Possible conserved transmembrane protein
Possible conserved integral membrane protein
Possible conserved transmembrane protein
Conserved hypothetical protein
Possible membrane protein
Possible transmembrane carbonic anhydrase
Possible integral membrane protein
Possible preprotein translocase
Possible conserved integral membrane protein
Possible NADH dehydrogenase
Possible integral membrane cytochrome d ubiquinol oxidase
Possible metal cation transporter atpase p-type
Possible ubiquinol-cytochrome c reductase
Possible conserved transmembrane protein
Phosphate-transport integral membrane abc transporter
Conserved membrane protein
2
3
3
3
3
3
3
3
3
3
3
3
7
3
3
3
10
3
7
3
3
3
7
7
3
7
3
3
3
-
11
11
11
11
11
11
11
11
10
10
10
10
10
10
10
10
10
10
9
9
9
9
9
9
9
8
8
8
[2]
[2, 4]
[2, 5]
[1, 2, 5]
[3]
[2, 5]
[2]
[5]
[2]
[1-3, 6]
[4]
[5]
[1-3, 5]
[5]
[1, 5]
Rv2113
Rv1622c
Rv2673
Rv1002c
Rv1132
Rv2994
Rv1431
Rv2877c
Rv1072
Rv2881c
Rv0110
Rv3806c
Rv2443
Rv1030
Rv3193c
Rv2051c
Rv1624c
Rv0167
Rv3481c
Rv2938
cydB
merT
cdsA
dctA
kdpB
ppm1
yrbE1A
drrC
Rv1858
Rv3501c
Rv1237
Rv0359
Rv3335c
Rv2937
modB
yrbE4A
sugB
drrB
Rv2693c
-
Possible integral membrane protein
Possible integral membrane cytochrome d ubiquinol oxidase
Possible conserved integral membrane protein
Conserved membrane protein
Conserved membrane protein
Possible conserved integral membrane protein
Conserved membrane protein
Possible conserved integral membrane protein
Possible conserved transmembrane protein
Possible integral membrane phosphatidate cytidylyltransferase
Possible conserved integral membrane protein
Possible conserved integral membrane protein
Possible c4-dicarboxylate-transport transmembrane protein
Possible potassium-transporting p-type ATPase b chain
Possible conserved transmembrane protein
Polyprenol-monophosphomannose synthase
Possible conserved membrane protein
Conserved hypothetical integral membrane protein
Possible integral membrane protein
Possible daunorubicin-dim-transport integral membrane protein abc
transporter
Possible molbdenum-transport integral membrane protein abc transporter
Conserved hypothetical integral membrane protein
Possible sugar-transport integral membrane protein abc transporter
Possible conserved integral membrane protein
Possible conserved integral membrane protein
Possible daunorubicin-dim-transport integral membrane protein abc
transporter
Possible conserved integral membrane alanine and leucine rich protein
3
3
7
3
3
3
3
3
3
3
1
3
3
3
3
3
3
3
0
3
3
-
8
8
8
8
8
8
8
7
7
7
7
7
7
7
7
7
6
6
6
6
3
0
3
3
3
3
-
6
6
6
6
6
6
3
-
6
[1, 3]
[5]
[2]
[4]
[1, 3, 5]
[1, 3-5]
[2, 3]
[3, 5]
[5]
[4]
Rv0308
Rv0936
Rv3689
Rv2093c
Rv3694c
Rv3783
pstA2
tatC
rfbD
Rv0180c
Rv1273c
-
Rv0969
Rv0235c
Rv1819c
ctpV
-
Rv2586c
Rv2587c
Rv1747
Rv1614
Rv0338c
Rv2120c
Rv3756c
Rv2136c
Rv1304
Rv3500c
Rv0168
Rv0364
Rv1236
Rv1216c
Rv0625c
secF
secD
lgt
proZ
atpB
yrbE4B
yrbE1B
sugA
-
Possible conserved integral membrane protein
Phosphate-transport integral membrane abc transporter
Possible conserved transmembrane protein
Possible sec-independent protein translocase transmembrane protein
Possible conserved transmembrane protein
Possible o-antigen/lipopolysaccharide transport integral membrane protein
abc transporter
Possible conserved transmembrane protein
Possible drugs-transport transmembrane ATP-binding protein abc
transporter
Possible metal cation transporter p-type ATPase
Possible conserved transmembrane protein
Possible drugs-transport transmembrane ATP-binding protein abc
transporter
Possible protein-export membrane protein
Possible protein-export membrane protein
Possible conserved transmembrane ATP-binding protein abc transporter
Possible prolipoprotein diacylglyceryl transferases
Possible iron-sulfur-binding reductase
Possible conserved integral membrane protein
Possible osmoprotectant
Possible conserved transmembrane protein
Possible ATP synthase a chain
Conserved hypothetical integral membrane protein
Conserved hypothetical integral membrane protein
Possible conserved transmembrane protein
Possible sugar-transport integral membrane protein abc transporter
Possible conserved integral membrane protein
Possible conserved transmembrane protein
4
3
3
3
3
3
3
-
6
6
6
6
6
6
[5, 6]
3
3
-
6
6
[1, 3, 5, 6]
3
3
3
-
6
6
6
[1, 3]
3
3
3
3
7
3
0
3
7
0
0
3
3
3
3
-
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
[1-3, 5]
[1-3, 5]
[2, 3]
[1, 3]
[1-3]
[3, 5]
[2]
[1-3]
[1, 3, 5]
Rv3238c
Rv0218
Rv1164
Rv1226c
Rv0249c
Rv1069c
Rv2620c
Rv2746c
Rv3092c
Rv1822
narI
pgsA3
pgsA2
Rv2563
Rv2637
Rv0072
Rv3671c
Rv2197c
Rv3069
Rv2560
Rv2869c
Rv3435c
Rv3101c
Rv2732c
Rv1610
Rv1749c
Rv2326c
Rv0563
Rv3277
Rv2536
dedA
rip
ftsX
htpX
-
Possible conserved integral membrane protein
Possible conserved transmembrane protein
Possible respiratory nitrate reductase
Possible transmembrane protein
Possible succinate dehydrogenase
Conserved hypothetical protein
Possible conserved transmembrane protein
Possible pgp synthase
Possible conserved integral membrane protein
Possiblecdp-diacylglycerol--glycerol-3-phosphate 3phosphatidyltransferase
Possible glutamine-transport transmembrane protein abc transporter
Possible transmembrane protein
Possible glutamine-transport transmembrane protein abc transporter
Possible membrane-associated serine protease
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Possible proline and glycine rich transmembrane protein
Membrane bound metalloprotease
Possible conserved transmembrane protein
Putative cell division protein
Possible conserved transmembrane protein
Possible conserved membrane protein
Possible integral membrane protein
Possible transmembrane ATP-binding protein abc transorter
Possible protease transmembrane protein heat shock protein
Possible conserved transmembrane protein
Possible conserved transmembrane protein
5
3
3
7
3
7
10
3
1
3
1
-
5
5
5
5
5
5
4
4
4
4
3
3
3
7
3
3
3
3
3
3
3
3
3
3
0
3
3
-
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
[2]
[5]
[1, 2]
[2]
[5]
[1, 3-5]
[5]
[1, 3]
[1, 4]
[3, 5]
[5]
[5]
[7]
[2]
[1-3, 5]
[6]
[1, 3]
[1, 4-6]
[5]
[1, 5-7]
Rv0954
Rv0412c
Rv3723
Rv1779c
Rv0870c
Rv3316
Rv3145
Rv1924c
Rv2617c
Rv2612c
Rv1342c
Rv3807c
Rv0461
Rv3632
Rv3104c
Rv3695
Rv3200c
Rv1481
Rv0093c
Rv1272c
sdhC
nuoA
pgsA1
-
Rv3317
Rv0176
Rv3479
Rv2284
Rv2235
Rv2200c
Rv2345
sdhD
lipM
ctaC
-
Possible conserved transmembrane protein
Possible conserved membrane protein
Possible conserved transmembrane protein
Hypothetical integral membrane protein
Possible conserved integral membrane protein
Possible succinate dehydrogenase
Possible NADH dehydrogenase
hypothetical protein
Possible transmembrane protein
Possible pi synthase
Conserved membrane protein
Possible conserved transmembrane protein
Possible transmembrane protein
Possible conserved membrane protein
Possible conserved transmembrane protein
Possible conserved membrane protein
Possible transmembrane cation transporter
Possible membrane protein
Possible conserved membrane protein
Possible drugs-transport transmembrane ATP-binding protein abc
transporter
Possible succinate dehydrogenase
Possible conserved mce associated transmembrane protein
Possible transmembrane protein
Possible esterase
Possible conserved transmembrane protein
Possible transmembrane cytochrome c oxidase
Possible conserved transmembrane protein
6
3
3
3
3
3
7
7
10
3
1
3
3
3
3
3
3
3
3
3
3
-
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
7
3
3
7
3
7
3
Lipo
-
3
3
3
3
3
3
3
[1, 5, 6]
[1, 6]
[1, 3, 5, 6]
[2]
[5]
[1]
[5]
[1]
[3]
[5]
[3]
[1-3]
[1, 3, 5, 6]
[2]
[3, 5]
[1, 2]
[1-3, 5]
[2]
[1, 3-6]
[1-3, 6]
Rv2195
Rv0497
Rv2146c
Rv0476
Rv0544c
Rv1487
Rv0879c
Rv0011c
Rv3851
Rv1417
Rv0531
Rv2698
Rv0514
Rv0556
Rv0985c
Rv0426c
Rv2843
Rv0010c
Rv3669
Rv0686
Rv3278c
Rv1234
Rv2772c
Rv0680c
Rv3732
Rv1227c
Rv1078
Rv3826
qcrA
mscL
pra
fadD23
Possible rieske iron-sulfur protein
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Conserved membrane protein
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Possible membrane protein
Possible conserved membrane protein
Possible conserved membrane protein
Possible conserved alanine rich transmembrane protein
Possible transmembrane protein
Possible conserved transmembrane protein
Possible large-conductance ion mechanosensitive channel
Possible transmembrane protein
Possible conserved transmembrane alanine rich protein
Possible conserved membrane protein
Possible conserved transmembrane protein
Possible membrane protein
Possible conserved transmembrane protein
Possible transmembrane protein
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Conserved hypothetical protein
Possible transmembrane protein
Possible proline-rich antigen homolog
Possible fatty-acid-CoA ligase
7
7
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
10
3
10
1
Lipo
-
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
[1-3, 5-7]
[5]
[6]
[3]
[6]
[3]
[1, 3]
[5]
[1]
[1, 3]
[3, 5, 6]
[1, 3]
[4, 5]
[1]
[3, 5, 6]
Rv1615
Rv0513
Rv3090
Rv1796
Rv0292
Rv2219
Rv2194
Rv1239c
Rv2721c
Rv2169c
Rv0007
Rv3165c
Rv1231c
Rv1343c
Rv0227c
Rv1489
Rv2219A
Rv3004
Rv0506
Rv2376c
Rv1209
Rv0677c
Rv3584
Rv0817c
Rv0291
Rv3883c
Rv3627c
Rv0309
mycP5
qcrC
corA
lprD
cfp6
mmpS2
cfp2
mmpS5
lpqE
mycP3
mycP1
-
Possible hypothetical membrane protein
Possible conserved transmembrane protein
Hypothetical alanine and valine rich protein
Possible proline rich membrane-anchored mycosin
Possible conserved transmembrane protein
Possible conserved transmembrane protein
Possible ubiquinol-cytochrome c reductase
Possible magnesium and cobalt transport transmembrane protein
Possible conserved transmembrane alanine and glycine rich protein
Possible conserved transmembrane protein
Possible conserved membrane protein
hypothetical protein
Possible membrane protein
Possible conserved lipoprotein
Possible conserved membrane protein
Conserved hypothetical protein
Possible conserved membrane protein
Low molecular weight protein antigen
Possible conserved membrane protein
Low molecular weight antigen
Conserved hypothetical protein
Possible conserved membrane protein
Possible conserved lipoprotein
Possible conserved exported protein
Possible membrane-anchored mycosin
Membrane-anchored mycosin
Conserved hypothetical protein
Possible conserved exported protein
8
3
3
10
7
3
3
7
3
3
3
3
10
3
3
3
10
3
3
3
3
10
3
3
3
7
7
10
3
Lipo
Omp
Omp
Omp
Omp
Omp
Lipo
Omp
Omp
Omp
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
[5]
[1, 3, 5, 6]
[5]
[1, 3]
[1, 2, 5]
[1, 5, 6]
[1, 5]
[1, 3-6]
[1, 8] [3]
[2]
[2]
[1, 5, 9]
[1]
[4]
[4]
[4, 9]
[3, 5]
[4]
[1, 3-6]
[1, 3, 4, 6]
[1, 4]
[4]
Rv2537c
Rv2980
Rv3864
Rv0052
Rv0392c
Rv2138
Rv0169
Rv2171
Rv1382
Rv2672
Rv0283
Rv2597
Rv0983
Rv1476
Rv0314c
Rv3497c
Rv1270c
Rv2945c
Rv3693
Rv0538
Rv1418
Rv3212
Rv3764c
Rv0419
Rv0172
Rv1368
Rv1825
Rv1782
aroD
ndhA
lppL
mce1A
lppM
pepD
mce4C
lprA
lppX
lprH
tcrY
lpqM
mce1D
lprF
-
3-dehydroquinate dehydratase
Possible conserved secreted protein
Conserved hypothetical protein
Conserved hypothetical protein
Possible membrane NADH dehydrogenase
Possible conserved lipoprotein
Mce-family protein
Possible conserved lipoprotein
Possible export or membrane protein
Possible secreted protease
Possible conserved membrane protein
Possible membrane protein
Possible serine protease
Possible membrane protein
Possible conserved membrane protein
Mce-family protein
Possible lipoprotein
Possible conserved lipoprotein
Possible conserved membrane protein
Possible conserved membrane protein
Possible lipoprotein
Conserved hypothetical alanine valine rich protein
Possible two component sensor kinase
Possible lipoprotein peptidase
Mce-family protein
Possible conserved lipoprotein
Conserved hypothetical protein
Possible conserved membrane protein
7
3
10
10
7
3
0
3
3
7
3
3
7
3
3
0
3
3
3
3
3
10
9
3
0
3
10
3
9
Omp
Lipo
Omp
Lipo
Omp
Lipo/Omp
Omp
Omp
Lipo
Lipo
Omp
Lipo
Omp
Lipo
Omp
Lipo
-
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
[3, 5, 9]
[2, 3]
[5]
[2]
[5]
[4]
[1, 4, 5]
[1-4]
[1, 3, 5, 7]
[3, 5, 6]
[5]
[1]
[1-6]
[1-6]
[2, 4]
[5]
[1, 2]
[2]
[5]
[1, 4]
[1-3, 5, 6]
[1]
[3]
Rv3683
Rv0931c
Rv0418
Rv0170
Rv2330c
Rv0173
Rv1022
Rv0174
Rv1836c
Rv3390
Rv1097c
Rv1488
Rv0144
Rv0888
Rv0899
Rv1881c
Rv1184c
Rv0592
Rv1566c
Rv3587c
Rv2518c
Rv1223
Rv0048c
Rv1280c
Rv0638
Rv3802c
Rv0171
Rv0014c
pknD
lpqL
mce1B
lppP
lprK
lpqU
mce1F
lpqD
ompA
lppE
mce2D
lppS
htrA
oppA
secE1
mce1C
pknB
Conserved hypothetical protein
Transmembrane serine/threonine-protein kinase
Possible lipoprotein aminopeptidase
Mce-family protein
Possible lipoprotein
Possible mce-family lipoprotein
Possible conserved lipoprotein
Mce-family protein
Conserved hypothetical protein
Possible conserved lipoprotein
Possible membrane glycine and proline rich protein
Possible exported conserved protein
Possible transcriptional regulatory protein
Possible exported protein
Outer membrane protein
Possible conserved lipoprotein
Possible exported protein
Mce-family protein
Possible inv protein
Possible conserved membrane protein
Possible conserved lipoprotein
Possible serine protease
Possible membrane protein
Possible periplasmic oligopeptide-binding lipoprotein
Possible preprotein translocase
Possible conserved membrane protein
Mce-family protein
transmembrane serine/threonine-protein kinase
10
10
9
3
0
3
3
3
0
10
3
3
3
9
3
3
3
0
0
3
3
7
3
3
3
3
0
9
Omp
Lipo
Omp
Lipo
Lipo
Lipo
Omp
Lipo
Omp
Omp
Omp
Lipo
Omp
Omp
Omp
Omp
Lipo
Lipo
Omp
Omp
-
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
[3, 9]
[1-3]
[1-3, 5, 6]
[3, 4]
[1, 4]
[5]
[2, 4, 5, 8]
[1, 3, 5, 6]
[1, 3, 5, 7]
[1, 2, 5, 6]
[1-7]
[2, 3]
[1, 5]
[2]
[2]
[4, 5]
[5]
[1, 2, 6]
[1, 3, 5-7]
[1, 2, 6, 7]
[1, 5]
[1, 3, 5, 6]
[5]
[5]
Rv2203
Rv0177
Rv1746
Rv2473
Rv1977
Rv0988
Rv2599
Rv0479c
Rv2224c
Rv2903c
Rv3484
Rv3690
Rv0008c
Rv2080
Rv2507
Rv1363c
Rv1754c
Rv0361
Rv2198c
Rv3852
Rv2091c
Rv1386
Rv1857
Rv1244
Rv2873
Rv1914c
Rv1325c
Rv0999
pknF
lepB
cpsA
lppJ
mmpS3
hns
PE15
modA
lpqZ
mpt83
PE_PGRS24
-
Possible conserved membrane protein
Possible conserved mce associated protein
Anchored-membrane serine/threonine-protein kinase
Possible alanine and proline rich membrane protein
Conserved hypothetical protein
Possible conserved exported protein
Possible conserved membrane protein
Possible conserved membrane protein
Possible exported protease
Possible signal peptidase
Possible conserved protein
Possible conserved membrane protein
Possible membrane protein
Possible lipoprotein
Possible conserved proline rich membrane protein
Possible membrane protein
Conserved hypothetical protein
Possible conserved membrane protein
Possible conserved membrane protein
Possible histone-like protein
Possible membrane protein
PE family protein
Possible molybdate-binding lipoprotein
Possible lipoprotein
Cell surface lipoprotein
Hypothetical protein
PE-PGRS family protein
Hypothetical protein
11
3
10
9
3
10
3
3
3
3
3
10
3
3
3
3
3
10
3
3
2
3
6
3
3
3
10
6
10
Lipo
Omp
Omp
Lipo/Omp
Omp
Lipo
Omp
Lipo
Lipo
Lipo
Omp
Omp
Lipo/Omp
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
0
0
0
0
0
0
0
[5]
[2, 3]
[2, 3]
[1, 3, 6]
[1-7]
[1, 6]
[2, 4]
[1, 3, 5]
[4, 6]
[2]
[1, 5]
[1, 3, 5]
[1, 6]
[1, 3, 5-7]
[4]
[2, 5]
[1, 3-5]
[3]
[1, 3-5]
Rv1275
Rv3298c
Rv0237
Rv3763
lprC
lpqC
lpqI
lpqH
Possible lipoprotein
Possible esterase lipoprotein
Possible conserved lipoprotein
19 kDa lipoprotein antigen precursor
3
3
3
3
Lipo
Lipo
Lipo
Lipo
0
0
0
0
Rv2046
Rv3705c
Rv0934
Rv0265c
Rv2565
Rv1166
Rv0411c
Rv0241c
Rv1016c
Rv2251
Rv0604
Rv1339
Rv1235
Rv3796
Rv0838
Rv3244c
Rv0906
lppI
pstS1
fecB2
lpqW
glnH
lpqT
lpqO
lpqY
atsH
lpqR
lpqB
-
Possible lipoprotein
Conserved hypothetical protein
Periplasmic phosphate-binding lipoprotein
Possible periplasmic iron-transport lipoprotein
Conserved hypothetical protein
Possible conserved lipoprotein
Possible glutamine-binding lipoprotein
Double hotdog hydratase
Possible conserved lipoprotein
Possible flavoprotein
Possible conserved lipoprotein
Conserved hypothetical protein
Possible sugar-binding lipoprotein
Conserved hypothetical protein
Possible conserved lipoprotein
Possible conserved lipoprotein
Conserved hypothetical protein
3
10
3
3
10
3
3
7
3
7
3
10
3
10
3
3
10
Lipo
Omp
Lipo
Lipo
Omp
Lipo
Lipo
Omp
Lipo
Omp
Lipo
Omp
Lipo
Lipo/Omp
Lipo
Lipo
Omp
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Rv0679c
Rv3623
Rv0432
Rv3878
Rv3006
Rv3572
lpqG
sodC
lppZ
-
Conserved hypothetical threonine rich protein
Possible conserved lipoprotein
Possible periplasmic superoxide dismutase
Conserved hypothetical alanine rich protein
Possible conserved lipoprotein
Hypothetical protein
10
3
0
10
3
10
Omp
Lipo
Lipo
Omp
Lipo
Omp
0
0
0
0
0
0
12
[2, 3, 5, 6]
[1]
[1, 2, 4-6]
[1, 3, 5-7,
9]
[3, 5]
[4]
[1-7]
[3-6]
[2]
[4-6]
[4, 5]
[3, 7]
[1]
[2-4]
[3]
[3]
[5]
[5]
[4]
[1, 2, 4-6]
[1, 3, 5, 6,
9]
[3, 5]
[1-3]
[1, 3, 5-7]
[1, 3-6]
[4]
Rv3576
Rv0799c
Rv1899c
Rv2068c
Rv0399c
Rv2116
Rv3033
Rv2784c
Rv2999
Rv2394
Rv1784
Rv1411c
Rv2041c
Rv1252c
Rv0526
Rv0932c
Rv0928
Rv1424c
Rv0583c
Rv2112c
Rv0846c
Rv2833c
Rv1274
Rv1006
Rv0088
Rv3547
lppH
lppD
blaC
lpqK
lppK
lppU
lppY
ggtB
lprG
lprE
pstS2
pstS3
lpqN
ugpB
lprB
-
Possible conserved lipoprotein
Conserved hypothetical protein
Possible lipoprotein
Class a beta-lactamase
Possible conserved lipoprotein
Possible conserved lipoprotein
Hypothetical protein
Possible lipoprotein
Possible conserved lipoprotein
Possible gamma-glutamyltranspeptidase precursor
Conserved hypothetical protein
Possible conserved lipoprotein
Possible sugar-binding lipoprotein
Possible lipoprotein
Possible thioredoxin protein
Periplasmic phosphate-binding lipoprotein
Periplasmic phosphate-binding lipoprotein
Possible membrane protein
Possible conserved lipoprotein
Conserved hypothetical protein
Possible oxidase
Possible sn-glycerol-3-phosphate-binding lipoprotein
Possible lipoprotein
hypothetical protein
hypothetical protein
Conserved hypothetical protein
13
3
10
3
7
3
3
10
3
3
7
10
3
3
3
7
3
3
3
3
10
7
3
3
10
10
10
Lipo
Omp
Lipo
Lipo
Lipo
Lipo
Omp
Lipo
Lipo
Lipo
Omp
Lipo
Lipo
Lipo
Lipo
Lipo
Lipo
Lipo
Lipo
Omp
Lipo
Lipo
Lipo
Omp
Omp
Omp
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
[5, 7]
[1]
[3, 4, 9]
[1-5]
[1, 3, 5]
[3-6]
[1-3, 5, 6]
[1, 3, 5]
[2, 4, 5]
[1-3, 5-7]
[2, 5]
[4]
[1, 3-6]
[1, 3-6]
[1, 4-6]
[2]
[1, 3-5]
[3]
[2, 5]
[5]
[1-3, 5-7]
[2, 3, 5, 9]
[1-3, 7]
Reference List
1. Xiong Y, Chalmers MJ, Gao FP, Cross TA, and Marshall AG: Identification of Mycobacterium tuberculosis H37Rv integral membrane
proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry.
J.Proteome.Res. 2005, 4: 855-861.
2. Mawuenyega KG, Forst CV, Dobos KM, Belisle JT, Chen J, Bradbury EM, Bradbury AR, and Chen X: Mycobacterium tuberculosis
functional network analysis by global subcellular protein profiling. Mol.Biol.Cell 2005, 16: 396-404.
3. Gu SL, Chen J, Dobos KM, Bradbury EM, Belisle JT, and Chen X: Comprehensive proteomic profiling of the membrane constituents of a
Mycobacterium tuberculosis strain. Mol.Cell Proteomics 2003, 2:1284-1296.
4. Malen H, Berven FS, Fladmark KE, and Wiker HG: Comprehensive analysis of exported proteins from Mycobacterium tuberculosis
H37Rv. Proteomics 2007, 7:1702-1718.
5. Malen H, Berven FS, Softeland T, Arntzen MO, D'Santos CS, De Souza GA, and Wiker HG: Membrane and membrane-associated
proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation
strategies. Proteomics. 2008, 8: 1859-1870.
6. Mattow J, Siejak F, Hagens K, Schmidt F, Koehler C, Treumann A, Schaible UE, and Kaufmann SH: An improved strategy for selective
and efficient enrichment of integral plasma membrane proteins of mycobacteria. Proteomics. 2007, 7: 1687-1701.
7. Sinha S, Kosalai K, Arora S, Namane A, Sharma P, Gaikwad AN, Brodin P, and Cole ST: Immunogenic membrane-associated proteins of
Mycobacterium tuberculosis revealed by proteomics. Microbiology 2005, 151: 2411-2419.
8. Schmidt F, Donahoe S, Hagens K, Mattow J, Schaible UE, Kaufmann SH, Aebersold R, and Jungblut PR: Complementary analysis of the
Mycobacterium tuberculosis proteome by two-dimensional electrophoresis and isotope-coded affinity tag technology. Mol.Cell Proteomics
2004. 3:24-42.
9. Rosenkrands I, King A, Weldingh K, Moniatte M, Moertz E, and Andersen P: Towards the proteome of Mycobacterium tuberculosis.
Electrophoresis 2000, 21: 3740-3756.
14
15