Detection of active colonic inflammation
by magnetic resonance enterography, including diffusion-weighted imaging, in
pediatric patients undergoing investigation for inflammatory bowel disease.
Brian Lee | Karl Muchantef | Najma Ahmed | Nagwa Wilson
McGill University Health Centre
We have no potential conflicts of interest to disclose.
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
MRE vs endoscopic and pathologic inflammation
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
21 patients (9-17 y) investigated for IBD
MRE within 6 w of colonoscopy
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Colon divided into six segments
Presence of diffusion restriction and enhancement recorded
for each segment
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
MRE results compared to biopsy and endoscopic findings
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Diffusion Restriction
Contrast Enhancement
Sn 77% Sp 82%
Sn 67% Sp 90%
when compared to biopsy
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Diffusion Restriction
Contrast Enhancement
Sn 67% Sp 77%
Sn 53% Sp 80%
when compared to endoscopy
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Diffusion Restriction
Contrast Enhancement
0.57
K 0.59
K
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Three recent studies evaluating DWI and colonic
inflammation; no histopathology in two, no segmental
subdivision in one
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Findings very similar to Dillman et al (2011), reported by the
segmental level, but with no differentiation between DWI and
enhancement
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Lower sensitivity and specificity than Sirin et al (2015), who
reported on DWI, but did not divide by segmental level.
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
Small sample size (n = 21)
Retrospective
Up to 6 weeks between MRE and colonoscopy
Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University
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Detection of Active Colonic Inflammation by MRE in Pediatric IBD | Lee B, Muchantef K, Ahmed N, Wilson N | McGill University