THERAPEUTIC TOLERANCE: FIRST-IN-HUMAN DATA
27th - 30th June 2017
Research Beehive, Old Library Building,
Newcastle University, Newcastle upon Tyne
DRAFT PROGRAMME
Tuesday 27th June
12.00
Registration and lunch
13.30
Professor John Isaacs
Welcome and introduction
13.40
Keynote speaker
Ron Germain (NIH, USA)
Imaging the immune system
Session 1- Cells and Mechanisms
Chaired by John Isaacs
14.30
14.50
15.10
15.30
15.50
16.10
Georg Hollander (Oxford, UK)
Ethan Shevach (NIH, USA)
Herman Waldmann (Oxford, UK)
David Samson (UCL, UK)
Discussion
The Thymus – a 2017 perspective
What’s the latest in regulatory T-cells
Novel antibodies with improved properties
What does CTLA4 really do?
Coffee break (Poster/exhibitor viewing)
Session 2 – Breaking Tolerance in Cancer
Chaired by Andy Mellor
16.30
16.50
17.10
17.30
17.50
Samir Khleif (Augusta, USA)
Ted Johnson (Augusta, USA)
Dario Vignali (Pittsburgh, USA)
Robert Wilkinson (Medimmune)
Discussion
19.00 (TBC)
Conference dinner
Rational design for combination immunotherapy
Trials and tribulations in breaking tumour tolerance
Tolerance and cancer
Immunological targets to combat cancer
Wednesday 28th June
Session 3 – New Concepts in Tolerance
Chaired by
08.30
08.45
09.05
09.25
Tea/coffee
09.45
Femke van Wijk (Utrecht, Netherlands)
10.05
10.25
10.45
Ignacio Anegon (Nantes, France)
Discussion
Paul-Peter Tak (Stevenage, UK)
George Kassiotis (CRICK, UK)
Coffee break (Poster/exhibitor viewing)
Session 4 – Short oral presentations
Chaired by
11.05
11.20
11.35
11.50
12.05
12.20
Lunch (Poster/exhibitor viewing)
Immunomodulation by vagal nerve stimulation
Endogenous retroviruses and the breakdown of
immune tolerance
Resetting T-cell regulation in Juvenile Idiopathic
Arthritis
CD8+ Tregs as mediators of immune tolerance
Session 5 – Tolerance Biomarkers in Autoimmune Disease
Chaired by
13.20
13.40
14.00
14.20
14.40
Maria Hernandez-Fuentes (KCL, UK)
John Isaacs (Newcastle, UK)
Georg Schett (Erlangen, Germany)
Helmut Jonuleit (Mainz, Germany)
Anish Suri (Turnhoutseweg, Belgium)
15.00
15.20
Discussion
Biomarkers in transplantation tolerance
Update on the RA-MAP consortium
Autoantibodies as tolerance biomarkers
Tolerogenic targets in regulatory T-cells
Parsing the TCR repertoire in RA to enable
tolerogenic trials
Coffee break (poster/exhibitor viewing)
The Great Debate (1)
Chaired by
15.40
16.40
18.40
Debate: Therapeutic Tolerance: Pie-in-the-Sky or Just-Around-the-Corner? Debaters to be
announced
Poster session
Close
Thursday 29th June
Session 6 – Cellular Therapies – first-in-human results
Chaired by
08.30
08.45
Tea/coffee
Giovanna Lombardi (KCL, UK)
09.05
09.25
Piotr Trzonkowski (Gdansk, Poland)
Maria Ester Bernardo (Milan, Italy)
09.45
Catharien Hilkens (Newcastle, UK)
10.05
James Hutchinson (Regensburg, Germany)
10.25
10.45
Discussion
11.05
David Wraith (Birmingham, UK)
11.25
11.45
12.05
Mark Peakman (KCL, UK)
Kei Kishimoto (Massachusetts, USA)
Ranjeny Thomas (Brisbane, Australia)
12.25
Willem van Eden (Utrecht, the Netherlands)
12.45
13.05
Discussion
Coffee break (Poster/exhibitor viewing)
Session 7 - Peptides
Chaired by
Apitope therapy in Multiple Sclerosis and other
conditions
Peptide therapy in diabetes
Tolerogenic nanoparticles
Dendritic-cell targeting platforms for antigenspecific immunotherapy
The enigma of heat shock proteins in immune
tolerance
Lunch (Poster/exhibitor viewing)
Session 8 – Tolerogenic Antibody Therapy
Chaired by
14.05
14.25
14.45
15.05
15.25
15.45
16.05
16.25
Tregs in solid organ transplantation: first-in-human
data
Treg therapies in type I diabetes
Mesenchymal stem cells for tolerance induction in
human disease
Tolerogenic dendritic cell therapy for rheumatoid
arthritis
Regulatory macrophages in kidney transplantation
– first-in-human data
Lucienne Chatenoud (Paris, France)
Alasdair Coles (Cambridge, UK)
Andy Cope (KCL, UK)
Mike Ehrenstein (UCL, UK)
Discussion
Coffee break (Poster/exhibitor viewing)
Anti-CD3 – an update
Alemtuzumab in Multiple Sclerosis
Treating very early autoimmunity
Anti-TNF as a tolerogenic therapy
The Great Debate (2)
Chaired by
16.45
17.45
Debate: This house believes that autoimmunity is simply a manifestation of perverted allergy.
Debaters to be announced
Close
19.00 (ish)
Conference dinner
Friday 30th June
08.30
08.45
Tea/coffee
Keynote speaker
Lars Klareskog (Stockholm, Sweden)
Session 9 – Metabolism and Metabolomics
Chaired by
Evolution of an autoimmune disease – a window of
opportunity for tolerance induction?
09.35
09.55
10.15
10.35
10.55
11.15
Andy Mellor (Newcastle, UK)
Hozefa Bandukwala (Massachusetts, USA)
Duncan Howie (Oxford, UK)
Eva Palsson-McDermott (Dublin, Ireland)
Discussion
IDO and tolerance – where are we now?
Anti-anabolic drugs and immunosuppression
How FoxP3 regulates immune metabolism
Metabolism and immune tolerance
11.35
Jaap van Laar (Utrecht, Netherlands)
11.55
12.15
12.35
12.55
13.05
13.25
Andreas Radbruch (Berlin, Germany)
Michelle Rosenzwajg (Paris, France)
Luis Graca (Lisbon, Portugal)
Claudia Mauri (London, UK)
Discussion
Hematologic transplantation as a therapy for
autoimmunity
Restoring B cell tolerance
Low dose IL-2 therapy
Tolerance to Factor VIII
Regulatory B Cells
Coffee break (Poster/exhibitor viewing)
Session 10 – Immunotherapeutics
Chaired by
Closing remarks and poster prizes (lunch)