Protein oxidation and peroxidation
by Michael J. Davies
Biochem. J.
Volume 473(7):805-825
April 1, 2016
©2016 by Portland Press Ltd
Examples of oxidant species (both two-electron oxidants and radicals) generated from activated
leucocytes and their interconversion
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Abundance of potential targets for one- and two-electron oxidants in various biological systems,
including plasma, liver and leucocytes
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Overview of biological fates of carbon-centred (R•, highlighted in red) and peroxyl radicals
(ROO•) in biological systems with subsequent formation of amino acid-, peptide- and proteinhydroperoxides (highlighted in blue)
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Summary of currently known oxidation systems that can give rise to amino acid-, peptide- and
protein-hydroperoxides in the presence of molecular oxygen (O2)
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Formation of hydroperoxides on reaction of Tyr phenoxyl radicals and Trp indolyl radicals with
the superoxide radical anion, O2−•
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Peroxidic species identified on reaction of singlet oxygen (1O2) with reactive methionine,
cysteine, tyrosine, histidine and tryptophan side chains
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Overview of one- (radical) and two-electron (molecular) reactions of amino acid-, peptide- and
protein-hydroperoxides (highlighted in blue)
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Secondary fragmentation, rearrangement and hydrogen atom abstraction reactions of alkoxyl
radicals (RO•) generated from amino acid-, peptide- and protein-hydroperoxides
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd
Potential fates of hydroperoxides present on amino acids, peptides and proteins in biological
systems
Michael J. Davies Biochem. J. 2016;473:805-825
©2016 by Portland Press Ltd