Strategies to improve vaccination uptake in Australia Summary of included studies by intervention category Increase community demand (n=20) Primary author a (year) Location Ballestas (2009) Evaluation b design Vaccine(s) and target group(s) Fremantle, Western Australia Descriptive (cross sectional, c pre/post ) Influenza Australian Capital Territory Descriptive c (pre/post ) NIP Perth, Western Australia Analytic e (RCT ) J Banks (2008) Intervention(s) Outcomes Conclusion Limitations Over 11,000 staff in 5 hospitals Social marketing campaign + education Vaccination coverage Increased coverage Variation in data collection methods Coverage could be overestimated Respondent bias Health care workers (HCWs) d n vaccinated = 6,387 Coverage = 55% 877 parents of children aged <5 years overdue for immunisation Recall letters + updating records 78% of initially overdue children were up to date Increased coverage None stated NIP 150 children Children Intervention = 75 Control = 75 Home visits + education for women post-partum No significant differences were detected in immunisations at 2 months (p=0.757), 4 months (p=0.477) or 6 months (p=0.283) post-partum between intervention group and control group No significant differences in coverage between intervention group and control group Self-report bias Insufficient power to detect clinically significant differences Measurement bias Selection bias Descriptive (cohort, c pre/post ) Influenza 580 patients Reminder letters + free appointments + nurse-led immunisation Vaccination coverage Increased coverage Potential temporal confounders Small sample Descriptive (cross sectional, post f only ) Influenza Multi-component interventions: education programs; mobile vaccination cart; declination forms; incentives; promotions; communication Average coverage Victorian public hospitals = 48.3% Study hospitals = 54.3% Support and resources are a more important barrier to achieving high coverage rates than the failure to use evidencebased strategies Small sample Subjective assessments Measurement tools not validated Difficulty in obtaining accurate coverage estimates Highly correlated nature of the variables limited statistical analysis Children C Bartu (2006) Sample size d J Byrnes (2006) Bundaberg, Queensland Older people J Victoria HCWs De Alwis (2010) J 17 hospitals 2004 = 77% 2005 = 83% Less than half (5/17) the study hospitals achieved state target of 60% Inverse relationship between vaccination coverage and number of acute beds – smaller hospitals achieved higher coverage Summary of strategies to increase vaccination uptake in Australia Page 1 of 13 Primary author a (year) Location Evaluation b design Vaccine(s) and target group(s) Sample size Intervention(s) Outcomes Conclusion Limitations Devine (2007) St Albans and Maldon, Victoria Descriptive (cohort, c pre/post ) Hepatitis B 204 prisoners Integrate vaccination with health assessments Vaccination coverage Achieved high coverage Small sample Measurement bias Activities limited due to challenging population Sydney, New South Wales Analytic (retrospective cohort) Influenza Patient education + reminder letter to general practitioner (GP) Vaccination coverage Higher coverage in intervention group than control group Selection bias Small sample Social desirability bias Self-report bias Not all interventions evaluated Descriptive (cohort, c pre/post ) Influenza State-wide coordination of influenza vaccine for HCWs incl. staff education and promotional material Vaccination coverage Increased coverage None stated Analytic e (RCT ) Measles-mumps 259 parents Vaccination coverage Children Intervention = 124 Control = 135 Reminder postcard based on Health Belief Model Higher coverage in intervention group than control group Measurement bias Confounding Selection bias Human papillomavirus (HPV) 159 students Two different information leaflets with information about the HPV vaccine framed as protecting against (1) cervical cancer (2) cervical cancer + genital warts Vaccination coverage Vaccine intention does not equate to behaviour Participants may be interested in the vaccine Recall letters Percentage up to date J Ferguson (2010) J Fullerton (2010) Across Queensland Behaviourally at risk (prisoners) 205 children Medically at risk (haematopoietic stem cell transplant [HSCT] patients and their families) Around 7,400 employees HCWs C Hawe (1998) Ballarat, Victoria J Sydney, New South Wales Analytic e (RCT ) Juraskova (2011) First year university students, female, aged under 27 J Kirby (2010) C Sydney, New South Wales Descriptive (cross sectional, c pre/post ) d NIP Children Summary of strategies to increase vaccination uptake in Australia Cervical cancer leaflet = 81 Cervical cancer + genital warts leaflet = 78 Not stated dose 1 = 83% dose 2 = 93% dose 3 = 84% Participants = 71% Non-participants = 30% 2006 = 26% 2009 = 58% Intervention = 79% Control = 67% 37% of total participants received vaccine 2 months after intervention Small sample Low HPV knowledge (22%) and high vaccination intention (79%) which was not influenced by information framing High attrition Increased coverage None stated July 2009 = 55% December 2009 = 70% Page 2 of 13 Primary author a (year) Location Queensland Evaluation b design Vaccine(s) and target group(s) Analytic e (RCT ) Tetanusdiphtheria + hepatitis B + influenza Lennox (2007) Sample size Intervention(s) Outcomes Conclusion Limitations 459 adults Integrate vaccination with health assessments Vaccination coverage Higher coverage in intervention group than control group Limited generalisability Potential information bias High staff turnover Higher coverage in intervention group than control group Contamination of the sample – underestimated effects Coverage higher than jurisdictional average Limited generalisability No formal evaluation activities undertaken No significant differences in coverage between intervention group and control group Limited generalisability Measurement deficiencies Intervention = 234 Control = 219 Medically at risk (adults with intellectual disability) J Tetanus-diphtheria Intervention = 25% Control = 3% Hepatitis B Intervention = 16% Control = 7% Influenza Intervention = 60% Control = 56% Puech (1998) Sydney, New South Wales Analytic e (RCT ) Influenza 325 elderly Older people Intervention = 154 Control = 171 Influenza Not stated J Melbourne, Victoria Scott (2010) Descriptive (cohort, post f only ) HCWs Reminder postcard Vaccination coverage Intervention = 64% Control = 46% (p=0.05) Staff education + promotional material + mass vaccination clinics C Number of vaccines administered to staff Seasonal influenza: 2,268 (65% uptake); average Victorian uptake = 53% Pandemic 2009 (H1N1) influenza vaccine: 1,548 (48% uptake) Melbourne, Victoria Skinner (2000) Analytic e (RCT ) Hepatitis B 17,411 students Adolescents (11–13 years of age) Intervention = 7,588 Control = 9,823 J Summary of strategies to increase vaccination uptake in Australia Education + promotional materials for students Vaccination coverage, knowledge and attitudes towards hepatitis B vaccination (1) 93% completed the 3-dose course (similar for intervention and control schools) (2) Coverage increased by 4–10% between low vs high implementation in intervention schools Page 3 of 13 Primary author a (year) Thomas (2008) Location Sydney, New South Wales J Perth, Western Australia Evaluation b design Vaccine(s) and target group(s) Descriptive (cross sectional, c pre/post ) Pneumococcal Descriptive (cohort, c pre/post ) NIP Sample size Intervention(s) Outcomes Conclusion Limitations GPs = 23 Babies = 13 Staff education + reminder stickers + patient promotion materials + Aboriginal Liaison Officers Vaccination coverage Increased coverage Activities limited by the available resources Limited generalisability Recall letters + promotional materials – based on a mascot Vaccination coverage, provider and consumer feedback Increased coverage None stated A targeted media campaign can increase vaccine uptake if it reinforces the seriousness of influenza illness and addresses community myths about the disease and vaccine. The use of dedicated vaccination clinics can also increase uptake. Limited generalisability Self-report bias Non-random sample Influence of the ‘healthy participant’ effect Influence of parental memory of childhood death cluster on vaccine uptake (not measured) Assessing the attributable benefit of mass marketing campaigns against high background coverage rates Increased coverage Limited generalisability No formal evaluation activities undertaken Aboriginal and Torres Strait Islander children d 35 general practices Children Increased from 30% to 40% (average for Sydney babies = 50%) Pilot program – 54.2% participating practices recorded a rise in ACIR coverage Tomney (2010) C First year post-pilot – 46% participating practices recorded an increase in ACIR coverage Western Australia Descriptive (cross sectional, post f only ) Influenza 546 parents Children aged 6–59 months Van Buynder (2010) J Free vaccine available from GPs and large public clinic in metropolitan area AND public marketing campaign targeting parents/guardians (2 waves) using mass media and targeted promotional letters The peak uptake of vaccine occurred in the week the program commenced though there was no evidence of a boost in uptake following the second phase of the campaign (6 weeks post launch) Vaccination coverage differed slightly by measurement method: CATI recruited dose 1 = 52% dose 2 = 47% WAIVE and sentinel GP recruited dose 1 = 52% dose 2 = 36% WaddingtonPowell (2008) Across South Australia Descriptive (cohort c pre/post ) Influenza HCWs Not stated Staff education + policy + promotional material Vaccination coverage 2006 = 51% 2007 = 57% C Summary of strategies to increase vaccination uptake in Australia Page 4 of 13 Primary author a (year) Wallace (2008) J Location Evaluation b design Vaccine(s) and target group(s) Sample size Intervention(s) Outcomes Conclusion Limitations North Coast, New South Wales Descriptive (cohort, c pre/post ) Pneumococcal Not stated Mass media (TV advertisements) Vaccine ordering patterns Increased orders for this vaccine Differences in effect not measured by target group Proxy measure used to estimate coverage No assessment of participant awareness or factors impacting program implementation Aboriginal and Torres Strait Islander people and older people Summary of strategies to increase vaccination uptake in Australia Significantly higher (p<0.001) proportion of vaccines ordered 33% increase compared to the same period in the previous year Page 5 of 13 Enhance access (n=15) Primary author a (year) Location Evaluation b design Vaccine(s) and target group(s) Melbourne, Victoria Analytic e (RCT ) dTpa and h MMR Bond (1998) g Sample size Intervention(s) Outcomes Conclusion Limitations 169 children Home visits Vaccination coverage and number of newborns up to date Higher coverage in intervention group than control group Randomisation strategy may have led to respondent bias Moderate increases in coverage Small sample No formal evaluation activities undertaken Increased coverage Limited generalisability No formal evaluation activities undertaken Intervention = 81 Control = 88 Children dTpa Intervention = 56% Control = 33% J MMR Intervention = 57% Control = 23% Brown (2010) Logan City, Queensland Descriptive c (pre/post ) DTPa-IPV h MMR g Children 2008–2009 = 13 schools Influenza Not stated C Melbourne, Victoria Elia (2010) Descriptive (cross sectional, post f only ) 2007–2008 = 9 schools All age groups Catch-up vaccines provided in primary schools Number of students vaccinated Mass vaccination clinic (hospital) + promotional materials Number of vaccines administered Consented = 490 (33%) Vaccinated previously = 350 (71%) Targeted for vaccination = 140 N targeted vaccinated = 97 (69%) 2005 = <500 2009 = 2,338 Types of target groups vaccinated: patients (71%), siblings (12%), parents (12%), staff (5%) C Summary of strategies to increase vaccination uptake in Australia Page 6 of 13 Primary author a (year) Location Evaluation b design Vaccine(s) and target group(s) Western Australia Analytic (cohort) Hepatitis A and B (combined or monovalent, 3 doses, varying schedules) Sample size Intervention(s) Outcomes Conclusion Limitations 1,209 notified hepatitis C cases Government funded vaccine could be ordered by GPs upon notification of newly diagnosed hepatitis C cases Notified cases ordering first dose of vaccine during study period = 37% Higher uptake of these vaccines compared to previous studies Measurement bias Low course completion Unlikely to have ordered vaccine(s) or completed course if patient was known to be immune to hepatitis A or B virus or had been partially vaccinated Not effective in increasing coverage None stated Achieved high coverage Sample may not be representative of the population Small sample Unknown comparators (i.e. population rate of AEFI) Medically at risk (adults newly diagnosed with hepatitis C) Fredericks (2010) J Of those who ordered an initial dose, 30% placed final dose orders Older patients, those with unknown Indigenous status and non-Indigenous patients were more likely to order at least one vaccine Administration of ordered vaccine Vaccine uptake in this study higher than the 8–9% reported in previous studies Gill (2010) Hobart, Tasmania Descriptive (cross sectional, post f only ) Pandemic influenza All age groups C Gold (2000) J Adelaide, South Australia; Sydney, New South Wales; Melbourne, Victoria Descriptive (cohort, post f only ) d NIP Medically at risk (children with a previous history of an adverse event following immunisation [AEFI]) Summary of strategies to increase vaccination uptake in Australia All Tasmanians in Launceston and those attending the Taste of Tasmania in Hobart in 2009 Mass vaccination clinics (public gatherings) 970 children Vaccination clinic for children with history of AEFI Descriptive data about likelihood of reaching younger and deprived populations Uptake was low in those aged <40 years and among disadvantaged residents Vaccination coverage 90% Page 7 of 13 Primary author a (year) Location Evaluation b design Vaccine(s) and target group(s) Sunshine Coast, Queensland Descriptive (cohort, c pre/post ) NIP + pneumococcal + adult diphtheriatetanus (ADT) + hepatitis B + h MMR + influenza Grant (2005) R d Sample size Intervention(s) Outcomes Conclusion Limitations 1,344 (20% of the Indigenous population in the Health Service District) Mass vaccination clinics (public places) + home visits Number of people vaccinated Increased coverage Intervention activities changed over time – measurement of outcomes challenging Free vaccine Vaccination coverage Increased coverage Lack information on intention to vaccinate pre-intervention Accelerated vaccination schedule Some increase in coverage Impact of other aspects of service delivery on coverage not evaluated Source of intention to vaccinate unknown Increased coverage None stated Achieved high coverage Limited generalisability No formal evaluation activities undertaken Before the program = 332 After = 1,344 All Aboriginal and Torres Strait Islander persons Howe (2009) Western Australia Descriptive (cohort, post f only ) Influenza HCWs 399 General Practice Network staff Analytic (cohort) Hepatitis B 2,085 patients 54% vaccinated, of which 34% had not received the vaccine previously R Sydney, New South Wales Behaviourally at risk (‘high risk’ patient attending sexual health centre) Macdonald (2007) J Piper (2008) Descriptive (cohort, post f only ) NIP Mt Isa, Queensland Descriptive (cohort, post f only ) Human papillomavirus (HPV) C Reeve (2008) J d Tweed Heads, New South Wales 2 doses Standard schedule = 45% Accelerated schedule = 50% 3 doses Standard schedule = 16% Accelerated schedule = 22% 276 children Aboriginal and Torres Strait Islander children ≤7 years of age Adolescents (10–13 years) Summary of strategies to increase vaccination uptake in Australia Vaccination coverage 304 students Reminder letters sent + personalised followup if no response Vaccination coverage School-based vaccination program delivered by GPs Consent form return rate = 94% Consent rate = 90% 34% completed 46% currently completing 0.5% conscientious objectors 93% up to date with scheduled vaccinations Vaccine uptake dose 1 = 89% dose 2 = 88% dose 3 = 79% Page 8 of 13 Primary author a (year) Location Evaluation b design Vaccine(s) and target group(s) Sydney, New South Wales Analytic (cohort) NIP d Sample size Intervention(s) Outcomes Conclusion Limitations 539 children Hospital-based catchup plan Vaccination coverage within a time-frame Improved timeliness of catch-up immunisation Recall bias Limited by use of retrospective data Reasons for delayed vaccination not given Achieved moderate coverage Limited by use of retrospective data Measurement bias Measurement deficit – seroprotection data Increased coverage Study did not detect temporal associations Confounding Improved provision of immunisation by GPs None stated Children Ressler (2008) Children with catch-up plan sig. more likely to be vaccinated within 30 days of admission (p=0.005) and within 90 days (p=0.04) compared to those without catchup plan J Rogers (2005) Melbourne, Victoria Descriptive (cohort, post f only ) Hepatitis B Descriptive (cohort, c pre/post ) NIP J Albury, New South Wales Smith (2010) 90 injecting drug users Behaviourally at risk (injecting drug users) d Not stated Children Accelerated vaccination schedule + personalised reminders Vaccination coverage Mass vaccination clinics (library setting) + promotional material Vaccination coverage and attendance records C 3 doses = 71% 2 doses = 11% 1 dose = 18% Two clinics run with total of 29 children attending (average in routine clinics = 6–8) Vaccination coverage increased by 14% in 6 months SESIAHS (2008) Wollongong and Illawarra area, New South Wales Descriptive (cohort, c pre/post ) Adult and childhood vaccines Medically at risk (refugees) 123 newly arrived refugees Hospital and general practice collaborative care model + staff education Consultation coverage All 64 (100%) children and 59 (95%) adults were seen by GPs and had recommended screening tests R 55% of children were underimmunised and received catch-up vaccines Summary of strategies to increase vaccination uptake in Australia Page 9 of 13 Provider-based interventions (n=8) Primary author (year)a Ali (2009) Location Sydney, New South Wales Evaluation design b Vaccine(s) and target group(s) Descriptive (cohort, c pre/post ) NIP Descriptive (cross sectional, c pre/post ) Routine vaccinations for Australian Defence Force personnel – g dTpa , polio, hepatitis A, hepatitis B, h typhoid, MMR , varicella d Sample size Intervention(s) Outcomes Conclusion Limitations 42 general practices Provider education + support at the general practice Vaccination coverage Increased coverage Measurement bias An audit of an electronic patient management database to determine vaccination currency of patients and accuracy of vaccination records % due at least one vaccination = 9.75% Increased coverage and awareness of those who were due for routine vaccination Audit only included those ‘due/overdue’ for vaccination. It is possible that the electronic vaccination records of ‘up to date’ patients are erroneous thus artificially inflating coverage. 12 aged care facility staff 630 residents Staff education + promotional materials Vaccination coverage of residents Increased coverage None identified 10,507 adults Provider reminders Significantly increased coverage None identified Increased provision of vaccines None identified Children J Sydney, New South Wales Colgrave (2010) J 800 patients at the Tobruk Lines Health Centre Proportion of general practices with >90% coverage increased from 30% to 68% Most commonly due vaccine = typhoid (n=73/94) The audit reduced the proportion of overdue vaccinations by 42% and increased coverage by 2%. Occupationally at risk (Australian Defence Force personnel) Finlay (2008) Albury, New South Wales C Frank (2004) Adelaide, South Australia Descriptive (cross sectional, c pre/post ) Influenza Older people e Quasi-RCT (non-blinded) J Tetanuscontaining h vaccine + MMR + influenza + pneumococcal 2007 = 87.5% 2008 = 92% Intervention = 5,118 Control = 5,389 Tetanus = 2.8% (p<0.05) Pneumococcal = 2.8% (p<0.05) MMR = 10.3% (p>0.05) Influenza = 26.2% (p>0.05) Adults Irwin (2002) C Melbourne, Victoria Descriptive (cohort, c pre/post ) Influenza + pneumococcal Medically at risk (children with ‘at risk’ conditions) Summary of strategies to increase vaccination uptake in Australia Not stated % increase in vaccination coverage Reminders (hospital based) + staff education Provision of vaccines Influenza = 2.5% Pneumococcal = 3.4% Page 10 of 13 Primary author (year)a Kerse (1999) Location Evaluation design b Vaccine(s) and target group(s) Sample size Intervention(s) Outcomes Conclusion Limitations Melbourne, Victoria Analytic e (RCT ) Influenza 42 GPs Education (for GPs) + provider reminders Vaccination coverage of patients Older people Intervention = 21 Control = 21 Significantly increased coverage Measurement bias Limited generalisability Selection bias Increased coverage No use of comparator No significant differences between reminder systems – both increased uptake Selection bias Lack of generalisability Insufficient power to detect differences in effect Increased from 66% to 73% (p=0.14) J Patients = 267 Lake (2008) Adelaide, South Australia Descriptive (cohort, post f only ) Influenza HCWs C 26 residential aged care facilities (RACFs) 10 RACFs participated Staff training + policy (standing orders for nurses) + free vaccine Vaccination coverage Residents = 80% Staff = 41% Vaccine provision also increased in participating RACFs Melbourne, Victoria MacIntyre (2003) Analytic e RCT ) Influenza + pneumococcal Older people J 131 elderly Intervention = 70 Control = 61 Reminders for hospital staff vs GPs Vaccination coverage Influenza Intervention = 63% Control = 53% Pneumococcal Intervention = 67% Control = 55% Summary of strategies to increase vaccination uptake in Australia Page 11 of 13 Regulatory interventions (n=6) Primary author a (year) Bond (2002) Location Melbourne, Victoria Evaluation b design Vaccine(s) and target group(s) Analytic (cross sectional) NIP Descriptive (cohort, c pre/post ) Hepatitis B (0, 2, 6 months schedule) d Sample size Intervention(s) Outcomes Conclusion Limitations 1997 = 1,578 2000 = 1,793 National policy – maternity immunisation allowance (MIA) + child care benefit (CCB) Vaccination coverage Increased coverage Measurement bias Study design not sufficient to detect temporal associations Limited generalisability Jurisdictional policy – vaccination of infants born after August 1990 Vaccination coverage in hospitals Some increase in coverage Measurement bias Jurisdictional policy – mandatory vaccination against specified diseases for HCWs Full compliance = 39–73% Increases in coverage following this policy have been modest and difficult to quantify Absence of baseline data prior to policy implementation Increased coverage Measurement bias Increased coverage Recall bias Potential data contamination Measurement bias Children J Connors (1998) Darwin, Northern Territory J 1993 = 2,054 1994 = 2,111 Increased from 84% to 93% 1993 – Hos A: 96%; Hos B: 71% 1994 – Hos A: 93%; Hos B: 77% Newborns New South Wales Helms (2011) Descriptive (cross sectional, post f only ) g h dTpa + MMR + varicella + hepatitis B 58 HCWs and executive staff (qualitative interviews) HCWs Number of unprotected staff reassigned or risk managed = 0–3 Proportion of students rejected for failure of compliance = 0–8% J No health region/service(s) completed implementation by target date (Dec 2008) Lam (1998) Sydney, New South Wales Analytic (cross sectional) Hepatitis B Descriptive (cross sectional, c pre/post ) dTpa + hepatitis B + i OPV + varicella + influenza + h j MMR + BCG 678 students Newborns J Melbourne, Victoria Smithers (2003) J g HCWs Summary of strategies to increase vaccination uptake in Australia 287 HCWs Jurisdictional policy – vaccination of neonates born to hepatitis B virus (HBV) carrier mothers Self-reported vaccination rates Hospital HCWs vaccination policy + part-time immunisation coordinator at the hospital Vaccination coverage Born before program = 31% Born after program = 68% Fully vaccinated: baseline = 19% vs follow-up = 24% (non-sig.) Vaccines with significant increases in coverage: (baseline; follow-up) OPV: 82%; 86% Hepatitis B booster: 25%; 33% BCG: 62%; 76% Page 12 of 13 Primary author a (year) Location Melbourne, Victoria Stewart (2002) J Evaluation b design Vaccine(s) and target group(s) Descriptive (cross sectional, c pre/post ) dTpa + hepatitis B + i OPV + varicella + influenza + h j MMR + BCG g Sample size Intervention(s) Outcomes Conclusion Limitations Baseline = 308 Follow-up = 209 Hospital HCWs vaccination policy Vaccination coverage No increase in coverage Sample size lower at follow-up Potential overestimation of effects Recall bias Insufficient time to observe effects HCWs New HCWs were significantly less likely to be immunised against hepatitis B No other significant differences with respect to vaccination coverage a. J = Journal C = Conference abstract R = Report b. Evaluation design as described in the article is classified according to Irwig and Cumming study types in population health research (Irwig and Cumming, 1988) c. Coverage measured in the same target group before and after the intervention d. Vaccines recommended on the Australian National Immunisation Program for children under the age of 7 years e. Randomised control trial f. Coverage measured in the same target group following the intervention only g. Diphtheria-tetanus-acellular pertussis vaccine (dTpa = reduced antigen content vaccine; DTPa-IPV = DTPa and inactivated polio virus (IPV) combination vaccine h. Measles-mumps-rubella vaccine i. Oral polio vaccine j. Bacille Calmette-Guérin vaccine Complete findings from this systematic review available in Ward K, Chow MYK, King C, Leask J. Strategies to improve vaccination uptake in Australia, a systematic review of types and effectiveness. Australian and New Zealand Journal of Public Health 2012; 36(4):369–77. doi 10.1111/j.17536405.2012.00897.x. Summary of strategies to increase vaccination uptake in Australia Page 13 of 13
© Copyright 2026 Paperzz