Thiolase Homolog A.pernix
C(H)H
Cyanobacterium
Synechococcus sp.
Thiolase A.fulgidus
Archaeal Thiolases
Thiolase M.acetivorans
Thiolase M.jannaschii
Thiolase I E.coli
Thiolase I H.sapiens (mitochodrial)
Thiolase I A.thaliana (peroxisomal)
C(N/H)HC
Thiolase I H.sapiens (peroxisomal)
Thiolases
Thiolase II E.coli
N2-fixing
Rhizobium
Moss
Physcomitrella patens
Horsetail
Equisetum hyemale
Mushroom
Phellinus linteus
Thiolase II Z.ramigera
Thiolase II A.thaliana (cytosolic)
Thiolase II H.sapiens (mitochodrial)
KAS I Synechocystis
KS/PKS S.coelicolor
KS/PKS P.cellulosum
KS/PKS S.erythraea
KAS II Synechocystis
CHH
KAS I E.coli
KAS I, II, KS/PKS
KAS II E.coli
KAS I A.fumigatus
KAS I A.oryzae
KAS I B.napus
KAS I A.thaliana
KAS I G.max
JamH L.majuscula
HMGS S.aureus
HMGS C.elegans
ECHN
OH
HMGS H.sapiens
HMGS A.thaliana
n
HMGS S.cerevisiae
HMGS M.jannaschii
HMGS M.acetivorans
KAS III M.tuberculosis
n
KAS III S.avermitilis
COOCH3
OH
OCH3
HMGS A.pernix
KAS III E.coli
KAS III Synechococcus
CHN
n
KAS III
OH
KAS III S.oleracea
KCS D.salina
KCS
KCS1 B.napus
KCS1 S.arvensis
PKS10 M.tuberculosis
PhlD Pseudomonas
RppA Streptomyces
CHSL Synechococcus
csyA A.oryzae
OH
OH
O
OH
Polyketide synthase
Polyketide synthase
Methyltransferase
Methyltransferase
Oxidoreductase
KCS2 M.polymorpha
KCS2 Z.mays
KCS1 A.thaliana
HO
HO
O
KAS III A.thaliana
KAS III G.max
OH
O
O
O
OH
O
O
O
O
OH
Alkylresorcinol synthase Coumaroyltriacetic acid
Acyldiacetic acid synthase
synthase
Hispidin synthase
PpCHS11 P.patens
STCS M.polymorpha
CHS P.patens
CHS Family
CHS P.nudum
STS P.strobes
CHS G.max
CHS M.sativa
Enzyme Discovery
CHS H.lupulus
CHS A.thaliana
CHS B.napus
Enzyme Evolution
Gene Regulation
Enzyme Structure
Enzyme Mechanism
HO
HO
O
O
Hydrolysis
first
Enzyme Function
HO
SCoA
O
SCoA
Cyclization
O
Tetraketide
intermediate O
O
O
O
first
Anther-specific Acyldiacetic Acid Synthases
in Plant Pollen (Exine) Synthesis and Male Fertility
O
HO
H2O
HO
CoASH
O
O
H2O
CoASH
HO
HO
O
O
OH
O
O
OH
O
Cyclization by stilbene synthase
HO
HO
SCoA
O
O-Acylation
O
O
O
O
O
HO
O
(18)
O
O
HO
S CoA
O
O
O
O
O
H218O
OH
HO
HO
OH 18
O
18
OH
Hydrolysis
& O-Acylation
O
O
O
O
O
O
O
Lactonization by type III polyketide synthases
H2O
O
O
O