IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
16th April 2012 - page 1-1
Organism tested
Source [journal name]
Sub ID
CAS Nr.
sodium tripolyphosphate (STPP)
0
7758-29-4
Henderson C. et al
1959
the toxicity of synthetic detergents and soaps to fish fish
sewage and industrial wastes 31: 295-306
sodium tripolyphosphate (STPP)
0
7758-29-4
Maloney T E
1966
Detergent phosphorus effect on algae.
algae
Journal of water pollutant control fed.38.38-45
Effect of Sodium tripolyphosphate (STPP) on the
embryonic developmental stages of Zebrafish
Brachydanio rerio
fish
Environment and ecology 18(4): 1007-1010
sodium tripolyphosphate (STPP)
0
7758-29-4
Sinha P. and Kanamadi R.D.
2000
sodium tripolyphosphate (STPP)
0
7758-29-4
Engelbrecht R S and Morgan J J
1959
sodium tripolyphosphate (STPP)
0
7758-29-4
Zinder B. et al
water
Sewage and industrial wastes.31.
1984
Studies on the occurrence and degradation of
condensed phosphate in surface waters.
Kinetic studies on the hydrolysis of STPP in sterile
solution
water
water res. 18: 509-512
2007
Risk Assessment on EU phosphate consumption,
effects assessment is based on validated field
studies.-CEFIC sector group study
N/A
Green Plant Research Report GPR-CEEP-07-1-Expanded
Final Report. (also Layman's Summary of Report)
de Madariaga B.M., Ramos M.J. and
Tarazona J.V
sodium tripolyphosphate (STPP)
0
7758-29-4
sodium tripolyphosphate (STPP)
0
7758-29-4
Inman M.P., Beattie J.K., Jones D.R.,
and Baldwin D.S.
2001
Abiotic hydrolysis of the detergent builder
tripolyphosphate by hydrous manganese dioxide.
water
Wat. Res. 35,8:1987-1993
sodium tripolyphosphate (STPP)
0
7758-29-4
Lyons JW
1964
Sodium Tri(poly)phosphate in the Kaolinite Water
System.
Clays
Journal of Colloid Science 19: 399-412
sodium tripolyphosphate (STPP)
0
7758-29-4
Smith R.S. Et al
1956
water
j am wat wks ass 48: 55-69
sodium tripolyphosphate (STPP)
0
7758-29-4
Sutton A.H
1973
cod
J. Fd Technol., 8: 185-195
N/A
J.phys.chem.102.2838-2841.
Hydrolysis of triphosphate from detergents in a
rural waste water system
N/A
Wat. Res. 35(2): 448-454
De Jager H and Heyns A M
sodium tripolyphosphate (STPP)
0
sodium tripolyphosphate
0
STPP,
0
7758-29-4
Kulaev AS and Vagabov VM
1983
STPP,
0
7758-29-4
Heppel LA, Harkness DR and
Hilmoe RJ
1962
STPP,
0
7758-29-4
Pepin CA and Wood HG
1986
STPP,
0
7758-29-4
Reddy BR
1987
Polyphosphate metabolism in micro-organisms.
A study of the substrate specificity and othe
properties of the alkaline phosphatase of
Escherichia coli.
Polyphosphate glucokinase from
Propionibacterium shermanii
Hydrolytic and enzymatic breakdown of food
grade condensed phosphates in white shrimp
(Penaeus Setiferus).
1982
1984
effect of the chelating agent sodium triphosphate on
cadmium toxicity in mice
mice
Chelation of cadmium review
N/A
sodium tripolyphosphate (STPP)
sodium tripolyphosphate (STPP)
0
0
1998
effects of synthetic detergents on water coagulation
The hydrolysis of sodium triphosphate in cod and
beef muscle.
Kinetics of acid-catalysed hydrolysis of a
polyphosphate in water.
Halliwell DJ, Mckelvie ID, Hart BT,
Dunhill RH
7758-29-4
7758-29-4
Adersen, O. Hagerstrand I., Nordberg
G.F.
Andersen O et al
n/a
Advances in Microbial Physiology, 24: 83-171
E.coli
bacteria
The Journal of Biological Chemistry, 237(3): 841-846
The Journal of Biological Chemistry, 261(10): 44764480
shrimp
Dissertation Abstracts International B47(): 4716
Publicly available published studies of which the IP Consortium has purchased a copyright copy
environmental research 29, 54-61
Environmental Health Perspectives. 54: 249-266
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
sodium tripolyphosphate (STPP)
Study
Year
Authors
Sub ID
CAS Nr.
0
7758-29-4
Andersen, O., Nielsen, J.B., Svendsen.
P.
1988
Object [title of the article]
sodium tripolyphosphate (STPP)
0
7758-29-4
Bajpai. A., Brahmi Z.
1993
sodium tripolyphosphate (STPP)
0
7758-29-4
Barica J. et al
1973
Sodium tripolyphosphate (STPP)
0
7758-29-4
Clairiant Hoescht
1975
Field evalution of fluorescent whitening agent and
sodium triphosphate as indictators of septic tank
contamination in domestic wells
0
7758-29-4
Close M et al
1989
sodium tripolyphosphate (STPP)
0
7758-29-4
Coate W B et al
1978
sodium tripolyphosphate (STPP)
0
7758-29-4
Corbridge D E C
1960
sodium tripolyphosphate (STPP)
0
7758-29-4
Davies D R and Corbridge D E C
1958
sodium tripolyphosphate (STPP)
0
7758-29-4
sodium tripolyphosphate (STPP)
0
7758-29-4
Engstrom B et al
1978
sodium tripolyphosphate (STPP)
0
7758-29-4
Engstrom B.
1984
sodium tripolyphosphate (STPP)
0
7758-29-4
Engstrom B.
1984
sodium tripolyphosphate (STPP)
0
7758-29-4
1978
sodium tripolyphosphate (STPP)
0
7758-29-4
Engstrom B., Nordberg. G.F.
FDA STPP authorisation
21.182.1810.pdf
Respiratory toxicity of enzyme detergent dust
The crystal structure of sodium triphosphate,
Na5P3O10 phase I.
The crystal structure of sodium tripolyphosphate,
Na5P3O10 phase II.
Structure studies of the two forms of sodium
tripolyphosphate.
Effects of detergent formula chelating agents on the
metabolism and toxicity of Cadmium in mice.
Effects of chelating agents on oral uptake and renal
deposition and excretion of cadmium
Effects of chelating agents on oral uptake and renal
deposition and excretion of cadium.
Effects of detergent formula chelating agents on the
metabolism toxicity of cadmium in mice
?
?
sodium tripolyphosphate (STPP)
0
7758-29-4
Foroutan-Rad M
1981
?
Dymon J J and King A J
1951
Organism tested
oral cadmium chloride intoxication in mice: effects of
chelation by STPP
mice
Regulation of Resting and IL-2 activated Human
Cytotoxic Lymphocytes by Exogenous Nucleotides:
Role of IL-2 and Ecto-ATPases
Mobilization of some metals in water and animal
tissues by NTA, EDTA and TPP
Akute orale toxizitat von natriumtripolyphosphate an
mannlichen und weilichen beagle-hunden
sodium tripolyphosphate (STPP)
16th April 2012 - page 1-2
Source [journal name]
Toxicology, 52: 65-79
venous blood human
cellular immunology 148: 130-143
sediments, crayfish, fish
Water res. 7: 1791-1804
dog
water
New Zealand journal of marine and freshwater
Research:23.563-568
Cynomologus Monkeys
Toxicology and applied pharmcology 45.471-496.
n/a
Acta Cryst.13,263.
n/a
Acta Cryst.11,315.
n/a
Acta Cryst.4.378
mice
Acta pharmacol et toxicol.43.387-397
mice
Environmental Health perspective 54: 219-232
mice
Environmental health perspectives.54.219-232.
mice
Acta pharmacol. Et toxicol. 43: 387-397
?
21 CFR Ch 1. (4-1-02 Edition), 45
ökologische und toxicologische Betrachtung. Umwelt 3:
218-224
sodium tripolyphosphate (STPP)
0
7758-29-4
Griffith EJ and Metcalf JS
1993
physiochemical properties
n/a
sodium tripolyphosphate (STPP)
0
7758-29-4
Griffiths EJ
1975
physiochemical properties
n/a
The solution properties of supersaturated sodium
triphosphate forms I and II. Phosphorus, Sulphur and
Silicon. 76:175-178.
The Chemical and Physical Properties of Condensed
Phosphates, 173-200
N/A
In vitro
Process Biochemistry. 43:83-92
Data book of chromosomal aberration test in vitro
hamster fibroblasts
Fd. Chem. Toxic. 22(8): 623-636
bacteria
n/a
applied and environmental microbiology: 842-846
n/a
sodium tripolyphosphate (STPP)
sodium tripolyphosphate (STPP)
0
0
7758-29-4
13573-18-7
Hsieh F.-M., Huang C., Lin T.-F., Chen
Y.-M. and Lin J.-C.
Ishidate M, Sofuni T.
2008
1998
sodium tripolyphosphate (STPP)
0
13573-18-7
Ishidate M. et al
1984
sodium tripolyphosphate (STPP)
sodium tripolyphosphate (STPP)
0
0
7758-29-4
7558-29-4
Jen C.M.C, Shelef L.A.
King CS
1986
1944
Study of sodium tripolyphosphate-crosslinked
chitosan beads entrapped with Pseudomonas putida
for phenol degradation.
chromosomal aberration test in vitro
primary mutagenicity screening of food additives
currently used in Japan
factors affecting sensitivity of Staphylococcus aureus
196E to polyphosphates
Manufacture of sodium triphosphates - patent
sodium tripolyphosphate (STPP)
0
7758-29-4
Linke et al
1965
Solubilities Inorganic and Metal-Organic Compounds water
K-Z A Compilation of Solubility Data from the Periodical
Literature Volume II 4th Edition. American Chemical
Society
sodium tripolyphosphate (STPP)
0
7758-29-4
Lynch RM
2000
Modeling of Exposure to Carpet-Cleaning Chemicals
Preceding Irritant Induced Asthma in One Patient.
Human
Environmental Health Perspectives, 108(9): 911-913
sodium tripolyphosphate (STPP)
0
7758-29-4
Matiuchices V.B et al
1984
toxicologic caracterization of STPP
Gigiena i Sanitariya 15: 97-101
rodents
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
sodium tripolyphosphate (STPP)
Sub ID
CAS Nr.
0
7758-29-4
Authors
Study
Year
Matyushichev VB et al
1984
Object [title of the article]
16th April 2012 - page 1-3
Organism tested
description of the toxicometric parameters of sodium
tripolyphosphate in Saccharomyces cerevisiae
yeast
Source [journal name]
Vestnik Leningradskogo Universiteta Biologiya 3: 97-101
sodium tripolyphosphate (STPP)
0
7758-29-4
Nishihata T. et al
1984
sodium tripolyphosphate (STPP)
0
7758-29-4
1990
sodium tripolyphosphate (STPP)
0
7758-29-4
1975
Interspecies comparisons of skin Irritancy
Rabbits
Toxicology and applied pharmacology 31: 481-490
sodium tripolyphosphate (STPP)
0
7758-29-4
1975
Interspecies comparisons of skin Irritancy
guinea pigs
Toxicology and applied pharmacology 31: 481-490
sodium tripolyphosphate (STPP)
0
7758-29-4
Nixon G A.et al
Nixon G.A., Tyson C.A. And Wertz
W.C.
Nixon G.A., Tyson C.A. And Wertz
W.C.
Nixon G.A., Tyson C.A. And Wertz
W.C.
possible mechanism behind the adjuvant action of
phosphate derivatives on rectal absorption of
Cefoxitin in Rats and Dogs
Evaultion of modified methods for determining skin
irritation.
1975
Interspecies comparisons of skin Irritancy
human
Toxicology and applied pharmacology 31: 481-490
sodium tripolyphosphate (STPP)
0
7758-29-4
Ohashi S and Takada S
1961
N/A
Journal unknown (Department of Chemistry, Kanazawa
University), 34(10): 1516-1518
sodium tripolyphosphate (STPP)
0
7758-29-4
Oshiba et al.
1979
Rats
sikatsu eisei 23(6): 209
sodium tripolyphosphate (STPP)
0
7758-29-4
Partiridge E P et al.
1941
Determination of ortho-, pyro- and tripolyphosphate
by the use of a small column of ion-exchange resin
The effect of tripolyphosphate and phytate on
mineral balance in rats
A thermal microscopic and X-ray study of the
system NaPO3-Na4P2O7
n/a
.Journal of American chemistry society.454
sodium tripolyphosphate (STTP)
0
7758-29-4
Schaffer JR and Woodhams RT
1977
Polyelectrolyte Builders as Detergent Phosphate
Replacements
N/A
Ind Eng Chem Prod Res Dev, 16: 3-11
1937
Solubility equilibria of sodium sulphate at
temperatures from 150°C to 350°C. III. Effect of
sodium hydroxide and sodium phosphate.
N/A
J. Am. Chem. Soc. 59(10): 1783-1790
1966
) Hydrolytic degradation of sodium tripolyphosphate
in concentrated solutions and in presence of foreign
ions
sodium triphosphate
sodium tripolyphosphate (STPP)
0
7758-29-4
0
Schroeder WC et al
Shen CY
dog and rats
Rabbits, Guinea-pigs,
humans
J. of pharmaceutical Science 73(11): 1523-1525
Regulatory toxicology and pharmacology.12.127-136
Ind Eng Chem Prod Res Dev 5: 97-100
7758-29-4
Shimizu H. et al
Sinton L.W., Finlay R.K and Hannah
D.J
1998
The results of microbial mutation test for forty-three
industrial chemicals (salmonella and Escherichia
coli)
Distinguishing human from animal faecal
contamination in water: a review.
0
7758-29-4
Synder et al
1963
Toxicologic Studies on Brighteners.
Toxicology and Applied Pharmacology, 5: 176-18
sodium tripolyphosphate (STPP)
0
7758-29-4
Taylor A.
1980
Soaps and Detergents and the Environment.
sodium tripolyphosphate (STPP)
0
7758-29-4
Valsami-Jones E
2004
n/a
sodium tripolyphosphate (STPP)
0
7758-29-4
Van Wazer jr and Campanella D
1950
physiochemical properties
Structure and properties of the condensed
phosphates III and IV
JAOCS, November 1980: 859A-861A
Phosphorus in Environmental Technology Principles and
Applications .
substance itself
J Amer Chem Soc 72: 647 - 663
Crustaceans
Ecotoxicology and environment safety 44: 196-206
river sediment
Environ. Chem. 4: 293-300
sodium tripolyphosphate (STPP)
0
13573-18-7
sodium tripolyphosphate (STPP)
0
sodium tripolyphosphate (STPP)
1985
sodium tripolyphosphate (STPP)
0
7758-29-4
Warne M.J. And Schifko A.D.
1999
Toxicity of laundry detergent components to a
freshwater cladoceran and their contribution to
detergent toxicity
sodium tripolyphosphate (STPP)
0
7758-29-4
Wellman D.M. Et al
2007
Efficacy of soluble sodium tripolyphosphate
amendments for the in-situ mobilisation of uranium
bacteria
water
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Jpn. J. Ind. Health 27: 400-419
New Zealand Journal of Marine and Freshwater Research,
32: 323-348
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
16th April 2012 - page 1-4
Organism tested
Source [journal name]
Sub ID
CAS Nr.
sodium tripolyphosphate (STPP)
0
7758-29-4
WHO
1970
sodium tripolyphosphate (STPP)
0
7758-29-4
Wieczorek J. et al
1996
Toxicological evaluation of some extraction solvents
and certain other substances
rat, rabbit
change in size of casein micelles caused by addition
of cleaning agent components
casein
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
Rats
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
dogs
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
Rabbits
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
Rabbits
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
Rabbits
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
Monkey
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
human
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
human
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
human
J am chem soc 49: 539-551
1972
Assessing detergent safety: a comparison of a
nonphosphate laundry detergent with phosphate
detergents
human
J am chem soc 49: 539-551
1966
1956
Research into the toxicity and effects of
polyphosphates on growth of cultures of amoeba,
rotifers, tadpoles, and on the succession of
organisms in cellulose decomposition
The hydration of sodium phosphate
Amoeba and rotifer and
Amphibian (Bufo bufo and institut fur Landwirtschaftliche Zoologie und bienenkunde,
Xenopus laevis)
Report 33 pages
N/A
. J. Am. Chem. Soc. 78(16): 3870-3871
bacteria
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
Type 1 detergent with sodium
tripolyphosphate
sodium tripolyphosphate (STPP)
sodium triphosphate
0
0
0
0
0
0
0
0
0
0
0
0
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
13573-18-7
7758-29-4
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Williams J.B. And Taber D.
Wuembach et al
Zettlemoyer AC and Schnieder CH
sodium tripolyphosphate
0
Seward RA, Diebel RH, Lindsay RC 1982
Effects of Potassium Sorbate and
OtherAntibotulinal Agents on Germination and
Outgrowth of Clostridium botulinum Type E
Spores in Microcultures
sodium tripolyphosphate
0
Steinhauer JE and Banwart GJ
1963
The Effect of Food Grade Polyphosphates on
the Microbial Population of Chicken Meat
bacteria
disodium orthophosphate
2
munzer DE
1898
?
?
Publicly available published studies of which the IP Consortium has purchased a copyright copy
FAO Nutrition Meetings Report Series No. 48A.
WHO/FOOD ADD/70.39
Netherlands Milk and Dairy J. 50: 53-59
Applied and evironmental microbiology. 44(5): 12121221
Poultry Science. 43:618-625
Archiv fur experimentelle Pathologie und
Pharmakologie 41: 74-96
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
monosodium phosphate (MSP)
2
7558-80-7
Brusick D
1975
monosodium phosphate (MSP)
2
7558-80-7
Bullock CH and Kamienski FX
1972
monosodium phosphate (MSP)
monosodium phosphate (MSP)
2
2
13472-35-0
7558-80-7
Fazekas, IG
Hitchman A.J. et al
1954
1979
monosodium phosphate (MSP)
2
7558-80-7
House WB and Hogan AG
1955
Mac Kay E M and Oilver J
1935
Object [title of the article]
Mutagenic evaluation of compound. FDA 73-2,
monosodium phosphate anhydrous powdered, FCC
grade
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Enlargement of parathyroid glands by simple acidic
compounds
phosphate induced renal calcification in the rat
Injury to guinea pigs that follows a high intake of
phosphates
Renal damage following the injection of a diet
containing an excess of inorganic phosphates.
monosodium phosphate (MSP)
2
7558-80-7
monosodium phosphate
monosodium phosphate (MSP)
2
2
7558-80-7
7558-80-7
Manowska J and Mazur L
McFarlane D.
1986
1941
monosodium phosphate (MSP)
Triple Super Phosphate,. DAP, sodium
dihydrogenorthophosphate
2
7558-80-7
1987
2
7558-80-7
Olivier P. and Marzin D.
Ivy RE, Sulivan TW, Goldner WJ, Graff
CR & Peo FR
monosodium phosphate (MSP)
2
13472-35-0
McMeniman N.P.
1973
Postnatal development of progeny after 5-HT and/or
32P treatment of mice on the first day of gestation.
experimental phosphate nephritis in the rat
Study of the genotoxic potential of 48 inorganic
derivatives with the SOS chromotest
availability and toxicity of fertiliser phosphates in the
rat
The toxic effect of some phosphate supplements fed
to sheep
monosodium phosphate (MSP)
2
7558-80-7
Sakano K. et al
1995
Inorganic phosphate as a negative conditioning
factor in plant cell culture
1972
monosodium phosphate
2
7558-80-7
N. F. Cymbaluk and G. I. Christison 1989
monosodium phosphate, dicalcium
phosphate
2
7758-80-7
Knowlton KF and Herbin JH
monosodium phosphate
2
7558-80-7
monosodium phosphate
2
7558-80-7
Lopez H, Kanitz FD, Moreria VR,
Wiltbank VR and Satter LD
Lopez H, Kanitz FD, Moreria VR,
Wiltbank VR and Satter LD
monosodium phosphate
2
7558-80-7
Matsuzaki H, Katsumata S, Uehara
M, Suzuki K, Miwa M
2007
monosodium phosphate
2
7558-80-7
Wu Z, Satter LD, Blohowiak AJ,
Stauffacher RH and Wilson JH
monosodium phosphate
2
7558-80-7
wu Z, Tallam S, Ishler VA and
Archibald DD
monosodium phosphate
monosodium phosphate (MSP)
2
2
7558-80-7
7558-80-7
Wu Z, Satter LD & Sojo R
Brandao J.C., Bohets H.L., Van De
Vyver I.E., Dierickx P.J.
2002
2004
2004
Effects of dietary energy and phosphorus
content on blood chemistry and development of
growing horses
Phosphorus Partitioning During Early Lactation
in Dairy Cows Fed Diets Varying in Phosphorus
Content
Effect of Dietary Phosphorus on Performance of
Lactating Dairy Cows: Milk Production and Cow
Health
Reproductive Performance of Dairy Cows Fed
Two Concentrations of Phosphorus
16th April 2012 - page 1-5
Organism tested
Source [journal name]
S. typhimuium,
Saccharomyces cerevisiae Litton Bionetics Inc. NTIS PB245508
Rabbits
Stauffer Western RC NTIS OTS0555931 (T-1861)
rabbits
rats
J. Anim. Sci. 80:1690-1695
can j physiol pharmac 57(1):92
Guinea pigs
The Journal nutrition. 55:507-518
?
Journal of experimental medicine.61
mice
Rats
Acta Physiologica Hungarica. 67(4): 419-422
J pathol. Bacteriol. 52: 17
bacteria
Mutation research, 189(): 263-269
rat
Poultry Science association meeting
sheep
Australian Veterinarian J. 49: 150-152
plant cells
plant science 107: 117-124
horse
J Anim Sci 1989. 67:951-958.
cows
J. Dairy Sci. 85:1227–1236
cows
J. Dairy Sci. 87:139–146
cows
Journal of Dairy Science 87(1) 146-157
2001
High-Phosphorus Diet Induces Osteopontin
Expression of Renal tubules in Rats
rats (mutant)
Milk Production, Estimated Phosphorus
Excretion,and Bone Characteristics of Dairy
Cows Fed Different Amounts of Phosphorus for
Two or Three Years
cowx
J. Dairy Sci. 84:1738–1748
2003
Utilization of Phosphorus in Lactating Cows Fed
Varying Amounts of Phosphorus and Forage
cow
J. Dairy Sci. 86:3300–3308
2000
Milk Production, Reproductive Performance,
and Fecal Excretion of Phosphorus by Dairy
Cows Fed Three Amounts of Phosphorus
cow
J Dairy Sci 83:1028–1041
1992
correlation between the in vitro cytotoxicity to
cultured fathead minnow fish cells and fish lethality
datas for 50 chemicals
fish cells (fathead minnow) Chemosphere 25(4):553-562 (558)
Publicly available published studies of which the IP Consortium has purchased a copyright copy
J. Clin. Biochem. Nutr., 41, 179–183,
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
Object [title of the article]
Organism tested
Source [journal name]
mice
Arch. Geschwulst. Forch. 51(7): 605-610
Drosphilia
mutat res, 31: 315-316
monosodium phosphate (MSP)
2
7558-80-7
Amlacher E. and Rudolph C.
1981
The thymidine incorporation inhibiting screening
system (TSS) to test carcinogenic substances (A
nuclear DNA synthesis suppressive short term test)
monosodium phosphate (MSP)
2
7558-80-7
Burki et al
1975
Influence of NaF and Na2PO3F on chemically
induced aberrations in mature sperm of drosophila
7558-80-7
Ittner J., Dambacher M.A., Muff R.,
Rüegsegger P., Trechsel U., and
Fischer J.A.
1986
monosodium phosphate (MSP)
2
1943
Reduced parathyroid hormone response to peroral
phosphate in osteoporotic patients.
human
Die Metaphosphate in KOLLOID-BEIHEFTE. Heft 14, p1-146
Heft 1-4, p1-146
1990
Studies of hydroxy-aluminium phosphates obtained
from pentahydroxy-dialuminum chloride and
monosodium phosphate
Arch. Pharm. 323: 447-451
1994
Development of rat one-cell embryos in a chemically
defined medium: effects of glucose, phosphate and
osmolarity.
rat (in vitro emvryo)
Karbe, K., und G. Jander
monosodium phosphate (MSP)
monosodium phosphate
2
2
7558-80-7
7558-80-7
Misheva E
Miyoshi K, Funahashi H, Okuda K and
Niwa K
monosodium phosphate (MSP)
2
7558-80-7
16th April 2012 - page 1-6
N/A
Mineral Electrolyte Metab. 12:199-203
Journal of Reproduction and Fertility. 100:21-26
monosodium phosphate (MSP)
2
7558-80-7
Niemeyer R. and Richter G.
1969
monosodium phosphate (MSP)
2
7558-80-7
Stookey G.K. And Muhler J.C.
1965
Rapidly labelled polyphosphates and
metaphosphates in the Blue-Green Alga Anacystis
nidulans
algae
anticariogenic effect in the rat of cereals fortified with
a soluble phosphate
Rats
2
7558-80-7
Unknown
?
Handbook of poisoning: prevention, diagnosis and
treatment.
human
Eleventh Edition. Lange Medical Publications.
Specification for the identity and purity of food
additives and their toxicological evaluation:
Emulsifiers, stabilizers, bleaching and maturing
agents. Who health organisation technical report
series No281.
guinea pig, rabbit, man
WHO
1998
Phosphate supplementation in young men: lack of
effect on calcium homeostasis and bone turnover.
?
European Journal of Clinical Nutrition, 52: 29-33
1939
Ricerche farmicologiche sul fosfato monosodico ?
Arch Farmacol Sper. 68:87-98
monosodium phosphate,calcium
phosphate
monosodium phosphate (MSP)
2
7558-80-7
WHO IPCS INCHEM identity purity food
additives P-acid & phosphates Tech
report 281 dated 1964
1964
Arch. Mikrobiol 69: 54-59
J. D. Res 45(3): 856-864
Whybro A et al
monosodium phosphate (MSP)
2
7558-80-7
monosodium phosphate
2
7558-80-7
Gajatto DS
The effects of a high monosodium phosphate
and alpha tocopherol supplemented milk
replacer diet on veal muscle color and
composition.
cow
Journal of animal science. 66:1676-1685.
1972
Osteoporosis in Aging Rats Induced by High
Phosphorus Diets
RAT
J Nutr. 102: 1133-1142
1964
Effects of calcium and phosphorous levels and
diethylstilbestrol on urinary calculi incidence
and feedlot performance of lambs
Sheep
J Anim Sci. 23:1079-1083.
sodium dihydrogenorthophosphate
(MSP)
2
7558-80-7
Agboola HA, Cahill VR, Conrad HR,
Ockerman HW, Pareent NA and
Plimpton RF
1988
sodium dihydrogenorthophosphate
2
7558-80-7
Draper HH, Sie TL and Bergan JG
monosodium phosphate
2
7558-80-7
Emerick RJ & Embry LB
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
monosodium phosphate
Sub ID
CAS Nr.
2
7558-80-7
Authors
Study
Year
Schryver H, Hintz H and Craig P
Object [title of the article]
Organism tested
Source [journal name]
1971
Calcium Metabolism in Ponies Fed a
High Phosphorus Diet
ponies
J. NUTRITION,101: 259-264.
minimal eventually lethal dose intravenous na2hpo4
acid sodium phosphate
Rabbits
disodium phosphate (DSP)
3
7558-79-4
Osser S
1933
disodium phosphate (DSP)
3
7558-79-4
Corbiau L
1936
disodium phosphate (DSP)
3
7558-79-4
Haworth S. et al
1983
disodium phosphate (DSP)
3
7558-79-4
Bullock CH and Kamienski FX
1972
3
1941
2004
Glomerular calcification induced by bolus injection
with dibasic sodium phosphate solution in SpragueDawley rats.
rat
Toxicologic Pathology. 32:408-412
2008
Early events involving glomerular calcification
induced by dibasic sodium phosphate solution in
rats.
rat
J Toxicol Pathol. 21: 229-237
Epifanio C.E., Sma R.F.
1975
Toxicity of ammonia, nitrite Ion, Nitrate Ion and
orthophosphate to mercenaria mercenaria and
crassostrea virginica
clam and oyster
institut fur Landwirtschaftliche Zoologie und bienenkunde,
Report 33 pages
cow
J. Anim. Pysiol. a. Anim. Nutr. 71 (1994), 15-21
fish
J. Nutr. 126: 324-331
Rabbits
j. periodont 38: 491-499
Drosphilia
Drosophila Information Service. 20: 87
rats
Biochem. Z.
7558-79-4
tsuchiya N, Matsushima S, Takasu N,
kypkawa Y and torii M
disodium phosphate (DSP)
3
7558-79-4
Tsuchiya N, Tprii M, Naramara I and
Matsui T
disodium phosphate (DSP)
3
arch ital sci farmacol 2(5)478-494
Modifications de la phosphatemie provoquees par
l'ingestion journaliere de phosphate bisodique
Salmonella Mutagenicity test results for 250
chemicals (see subst. 216)
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
A study of the relative toxicity of anions, with
polycelis nigra as test animals.
Erichsen Jones JR
disodium phosphate (DSP)
16th April 2012 - page 1-7
7558-79-4
disodium phosphate (DSP)
3
7558-79-4
disodium phosphate (DSP)
3
7558-79-4
schonewille JT, Klooster AT &
Beynen AC
1993
disodium phosphate
3
7558-79-4
Rodenhutscord M
1996
High phosphorus intake depresses apparent
magnesium absorption in pregnant heifers
Response of Rainbow Trout (Oncorhynchus
mykiss) Growing from 50 to 200 g to
Supplements of Dibasic Sodium Phosphate in
a Semipurified Diet
Rabbit corneal irrigation as a model System for
studies on the relative toxicity of bacterial products
implicated in periodontal disease. The toxicity of
neutralised ammonia solutions
dog
CR Soc Biol. 122: 474-475
bacteria
environmental mutagenesis supplement 1: 3-142
Rabbits
Stauffer Western RC NTIS OTS0555931 (T-1861)
polycelis nigra
Journal of Experimental Biology. 18: 170-181.
disodium phosphate (DSP)
3
7558-79-4
Rizzo A.A.
1967
disodium phosphate (DSP)
3
7558-79-4
Milani R
1946
disodium phosphate (DSP)
3
7558-79-4
Abelin. I.
1928
Induction of mutations with Na3PO4
effects of sodium phosphates and calcium salts on
the hormones produced by the thyroid gland
1979
Iron poisoning: Complications of hypertonic
phosphate lavage therapy. Brief clinical and
laboratory observations.
Drosphilia
N/A
Bachrach L., Correa A., Levin R. and
Grossman M.
disodium phosphate (DSP)
disodium phosphate (DSP)
3
3
7558-79-4
The Journal of Pediatrics. 94,1:147-149
7558-79-4
Buzzati-traverso A
19401946
Scientia Genetica. Vol II. Milani R. Produzione di
mutazioni letali in Drosophila melaongaster per
mezzo di fosfato di sodio
1978
N/A
N/A
N/aA
1938
Influence of dietary calcium and phosphorous upon
action of vitamin D in experimental lead poisoning
rat
Proc Soc Exper Biol Med. 38: 435
disodium phosphate (DSP)
3
7558-79-4
Report of the scientific committee for
food. 7th Series. Commission of the
European communities.
disodium hydrogenorthophosphate
(DSP)
3
7558-79-4
Sobel A, Wexler I, Petrovsky D and
Kramer B
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
disodium phosphate, zinc phosphide,
sodium hypophosphite, calcium
hypophosphite
trisodium phosphate (TSP)
trisodium phosphate (TSP)
trisodium phosphate (TSP)
trisodium phosphate (TSP)
Study
Year
Authors
3
4
4
4
4
CAS Nr.
7558-79-4
7601-54-9
7601-54-9
7601-54-9
7601-54-9
Lecoq R and Villius F
EFSA
EFSA
European Commission
Scientific Committee on Health and
Environmental Risks (SCHER)
Object [title of the article]
16th April 2012 - page 1-8
Organism tested
Source [journal name]
1932
Action de quelques composes inorganiques du
phosphore sur l'evolution du rachtisme experimental
du rat
rat
CR Soc Biol. 109:630-631
2005
Opinion of the scientific panel on food additives,
flavourings, processing aids and materials in contact
with food (AFC) on a request from the Commision
related to treatment of poultry carcasses with
chlorine dioxide, acidified sodium chlorite, trisodium
phosphate and peroxyacids
N/A
The EFSA Journal 297.1-28
2008
Assesment of the possible effect of the four
antimicrobial treatment substances on the
emergence of antimicrobial resistance
EFSA: Summary of opinion
2003
Opinion onf the Scientific Committee on veterinary
measures relating to public health: the evaluation of
antimicrobial treatments for poultry carcasses
N/A
European Commission
2008
Environmental impact and effect on antimicrobial
resistance of four substances used for the removal
of microbial surface contamination of poultry
carcasses
N/A
European Commission
1982
Workplace environmental exposure level guide:
trisodium phosphate.
where applicable, mouse,
rabbit, rat
American Industrial Hygiene Association Journal . 43():b51b52
N/A
Unknown author
trisodium phosphate (TSP)
4
7601-54-9
trisodium phosphate (TSP)
4
7601-54-9
Snider
1993
trisodium phosphate (TSP)
4
7601-54-9
Ufodike EBC et al
trisodium phosphate (TSP)
4
7601-54-9
Fraile A and Sang H
1990
Can chemicals precipitate dermatitis herpetiformis
human
Acute toxicity of inorganic fertilizers to African catfish
Clarias gariepinus
catfish
J Am Aced Dermatol 28(1): 111-112
Aquaculture and Fisheries Management, 21: 181-185
1950
Induction of mutation with Na3PO4 and with
Harmine
Drosphilia
Drosophilia Information Service. 24: 81.
bacteria
Biomedical and environmental sciences, 7: 144-149
trisodium phosphate (TSP)
4
7601-54-9
Arfsten et al
1994
Reversion of bioluminescent bacteria (Mutatox) to
their luminescent state upon exposure to organic
compounds, munitions, and metal salts
trisodium phosphate (TSP)
4
7601-54-9
Bates J.H.
1967
effect of sodium hydroxide and trisodium phosphate
on the viability of some unclassified mycobacteria
mycobacteria tuberculosis health lab Sci 4(1):42-50
trisodium phosphate (TSP)
4
7601-54-9
Buzzati-Traverso A
trisodium phosphate (TSP)
4
7601-54-9
Capita R, Alonso-Calleja C, GarciaFernandez MC and Moreno B
1947
Sull'effectto mutageno del fosfato di sodio.
?
Ricerca Scientifica E Ricostruzione.17(9-10): 1383-1384
2001
Influence of strain and trisodium phosphate
concentration on growth parameters of Listeria
monocytogenes in vitro
Bacteria: Listeria
Letters in Applied Microbiology. 32: 428-432
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
trisodium phosphate (TSP)
trisodium phosphate (TSP)
Study
Year
Authors
4
4
CAS Nr.
Sensitivity of Listeria monocytogenes to trisodium
fosfate in vitro
Mapfre Medicina. 11(4): 264-273
Some of the higher hydrates of trisodium phosphate
Na3PO4 and trisodium vanadate Na3VO4
N/A
7601-54-9
Clark GL and Gross ST
1937
trisodium phosphate (TSP)
4
7601-54-9
trisodium phosphate (TSP)
4
7601-54-9
Del Rio E, Capita R, Prieto M & AlonsoCalleja C
2006
Dickson JS, Nettles Cutter CG,
Siragusa GR
1994
trisodium phosphate (TSP)
4
7601-54-9
D'Souza DH & Su X
7601-54-9
7601-54-9
7601-54-9
Kim JW, Slavik MF, Pharr MD, Raben
DP, Lobsinger CM and Tsai S
Mu D, Huang Y, Gates KW and Wu W
7601-54-9
trisodium phosphate (TSP)
4
7601-54-9
trisodium phosphate (TSP)
4
7601-54-9
Z. Krist. 98:107-111
food Microbiology. 23: 195-198
Journal of Food Protection. 57(11): 952-955
Foodborne pathogens and Disease. 1-7
1943
N/A
Amer. Min. 28:448-455
1993
Reduction of Salmonella on post-chill chicken
carcasses by trisodium phosphate (Na3PO4)
treatment
Salmonella
Journal of food safety. 14(1): 9-17
Bacteria: Listeria
Journal of Food Safety. 17(1): 37-46
n/a
Physik Chem A, 159, 268-276
1997
1932
Phillips CA & Duggan J
Slanvin MF, Kim J, Pharr MD, Raben
DP, Tsai S & Lobsinger CM
Comparison of pathogenic and spoilage bacterial
levels on refrigerated poultry parts following
treatment with trisodium phosphate
Bacteria
Antimicrobial effects of trisodium phosphate against
bacteria attached to beef tissue
Bacteria
Viruses
Muus J
4
Listeria monoctogenes
Efficacy of chemical treatments against murine
norovirus, feline calicivirus, and MS2 bacteriophage
preparation and properties of some compounds in
the system H2O-Na2O-P2O5
?
Ingerson E. and Morey G.W.
trisodium phosphate (TSP)
Food Microbiology . 19: 57-63
Journal of Food Protection. 65(5): 853-856
4
4
Bacteria: Listeria
7601-54-9
trisodium phosphate (TSP)
trisodium phosphate (TSP)
Activity of trisodium phosphate compared with
sodium hydroxide was solutions against Listeria
monocytogenes attached to chicken skin during
refrigerated storage
Influence of Poultry Carcass Skin Sample site on the
effectiveness of trisodium phosphate against Listeria
monocytogenes
Listeria monoctogenes
7601-54-9
4
Source [journal name]
Capita R, Alsonso-Calleja C, RodriguezPerez R, Moreno B and GarciaFernandez MC
2002
2002
4
trisodium phosphate (TSP)
Organism tested
7601-54-9
trisodium phosphate (TSP)
4
Object [title of the article]
Capita R, Alonso-Calleja C, GarciaFernandez MC and Moreno B
Capita R, Alsonso-Calleja C, Sierra
Castrillo M, Garcia Arias MT, Moreno B
and Garcia-Fernandez MC
2000
trisodium phosphate (TSP)
16th April 2012 - page 1-9
2001
1994
trisodium phosphate (TSP)
4
7601-54-9
Somers EB, Schoeni JL, Wong ACL
1994
trisodium phosphate (TSP)
4
7601-54-9
Wendrow B & Kobe KA
1952
trisodium phosphate (TSP)
4
7601-54-9
Yuk H, Marshall DL
2006
trisodium phosphate (TSP)
4
7601-54-9
Zhuang RY & Beuchat LR
1996
sodium acid pyrophosphate (SAPP)
5
7758-16-9
Bullock CH and Kamienski FX
1972
Effect of trisodium phosphate on Listeria
monocytogenes attached to rainbow trout
(oncorhynchus mykiss) and shrimp (Penaeus SPP)
during refrigerated storage
Die H.ydrolysegeschwindigheit von
Pyrolrhosphorsânre.
The effects of EDTA and trisodium phosphate, alone
and in combination with nisin, on the growth of
Arcobacter butzleri in culture
Bacteria
Effect of trisodium phosphate on Campylobacter
attached to post-chill chicken carcasses
Bacteria
Effect of trisodium phosphate on biofilm and
planktonic cells of Campylobacter jejuni, Escherichia
coli O157: H7, Listeria monocytogenes and
Salmonella typhimurium
Bacteria: various
The system sodium oxide - phosphorus pentoxide water
n/a
Effects of trisodium phosphate adaptation on
changes in membrane lipid composition, verotoxin
secretion, and acid resistance of Escherichia coli
O157:H7 in simulated gastric fluid
Effectiveness of trisodium phosphate for killing
Salmonella montevideo on tomatoes
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Food Microbiology. 18:547-554
Journal of Food Protection. 57(4): 324-326
International Journal of Food Microbiology. 22: 269-276
Ind Eng Chem. 4: 1439-1448
Bacteria
International Journal of Food Microbiology. 106: 39-44
Bacteria: Salmonella
Letters in Applied Microbiology. 22: 97-100
Rabbits
Stauffer Western RC NTIS OTS0555931 (T-1861)
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
Craig JM
sodium acid pyrophosphate (SAPP)
5
7758-16-9
sodium acid pyrophosphate (SAPP)
5
7758-16-9
sodium acid pyrophosphate (SAPP)
5
7758-16-9
1957
Sprague J.B. And Logan W.J.
1979
Jorgenson T.A. Et al
1978
Object [title of the article]
16th April 2012 - page 1-10
Organism tested
Histologic and histochemical changes in the kidneys
of rats fed a diet with an excess of inorganic
phosphate.
rat
Separate and joint toxicity to rainbow trout of
substances used in drilling fluids for oil exploration
ABSTRACT: In vivo mutagenesis investigations of
four GRAS chemicals
Source [journal name]
Am J Pathol. 33:
fish
Environ. Pollut 79 :269-280
Rats
Mutation research, 53: 205
Gao RC et al
sodium acid pyrophosphate (SAPP)
5
7758-16-9
2006
Lambert S M, Watters J I
sodium acid pyrophosphate (SAPP)
sodium acid pyrophosphate (SAPP)
5
5
7758-16-9
7758-16-9
1957
Wagner M.K. And Busta F.F.
1985
Zhu MJ et al
sodium acid pyrophosphate (SAPP)
5
7758-16-9
2004
Marcy JA, Kraft AA, Hotchkiss DK,
Molins RA, Olson DG, Walker HW
and Merkenich K
1988
6
14691-80-6
Trisodium monohydrogen
pyrophosphate
6
14691-80-6
Hubbard FE
1949
Tetrasoidum pyrophosphate (TSPP)
7
7722-88-5
Bailey DE
Tetrasoidum pyrophosphate (TSPP)
7
7722-88-5
Tetrasoidum pyrophosphate (TSPP)
7
7722-88-5
7
7722-88-5
bacteria
bacteria
JOURNAL OF FOOD SCIENCE. 53(2): 391-393
N/A
Ind Eng Chem 41(12): 2908-2911
1976
mice, Rats
NTIS PB245534: Report No: FDABF-GRAS-353
Brusick D
1975
Mutagenic evaluation of compound. FDA 73-1,
tetrasodium pyrophosphate
S. typhimuium,
Saccharomyces cerevisiae Litton Bionetics Inc. NTIS PB245489
Mnkeni P.N.S. And MacKenzie A.F.
1987
Effects of added organic residues and calcium
carbonate on polyphosphate hydrolysis in four
Quebec soils
soil
Plant and soil 104: 163-167
1994
Metal Ions Reverse the Inhibitory Effects of
Selected Food-Grade Phosphates in
Staphylococcus aureus
Bacteria
Journal of Food Protection. Vol. 57. No. 4. Pages
284·288.
Lee RM, Bartami PA, Olson DG &
Wiliams FD
1941
MacArthur DM and Beevers CA
1957
The crystal structure of sodium pyrophosphate
decahydrate, Na4P2O7.10H2O
7758-16-9
Rao RVGS and Nampoothiri NS
1955
7
7722-88-5
Tono H and Kornberg A
1967
Unit cell and space group of sodium pyrophosphate
Biochemical studies in effects of phosphates in
bacterial sporulation.
8
7785-84-4
Finn SB et al
1978
The effect of sodium trimetaphosphate as a chewing
gum additive on caries increment in children
human
7722-88-5
1970
Bonneman-Bémia P.
Tetrasoidum pyrophosphate (TSPP)
7
7722-88-5
tetrasodium pyrophosphate
(decahydrate)
7
7758-16-9
tetrasodium pyrophosphate
(decahydrate)
7
Tetrasoidum pyrophosphate (TSPP)
sodium trimetaphosphate (STMP)
applied and environmental microbiology July: 16-20
Sheep
The interaction of kaolinite with polyphosphate and
polyacrylate in aqueous solutions - some preliminary
results.
N/A
Contribution a l'étude des acides phosphoriques
condensés.
N/A
7
J Am Chem Soc 79: 4262 - 4265.
Trisodium monohydrogen pyrophosphate and its
hydrates
Teratologic evaluation of FDA 73-1 tetrasodium
pyrophosphate, anhydrous in mice and rats.
Bidwell J.I., Jepson W.B. and Toms
G.L.
Tetrasoidum pyrophosphate (TSPP)
Inhibition of Clostridium botulinum 52A Toxicity and
Protease Activity by Sodium Acid Pyrophosphate in
Media Systems
Effect of Maternal Nutrient Restriction in Sheep on
the Development of Fetal Skeletal Muscle.
LWT 41: 254-261
Effects of Selected Commercial Phosphate
Products on the Natural Bacterial Flora of a
Cooked Meat System
trisodium pyrophosphate
tetrasodium pyrophosphate
Purification and characterization of pyrophosphatase
from bighead carp (Aristichthys nobilis).
Fish
The complexes of pyrophosphate ion with alkali
metal ions.
N/A
Clay Minerals. 8: 445-459
Ann. Chim. 16:395-477
N/A
Acta Cryst. 10, 428-432
N/A
Acta cryst. 8:850
Bacteria
Journal of Biological Chemistry: 242(10): 2375-2382
Publicly available published studies of which the IP Consortium has purchased a copyright copy
j am den assoc 96: 651-655
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
sodium trimetaphosphate (STMP)
Study
Year
Authors
8
CAS Nr.
7785-84-4
Navia J.M. And Harris R.S.
1969
sodium trimetaphosphate (STMP)
8
7785-84-4
Navia J.M., Lopez H. And Harris R.S.
1968
sodium trimetaphosphate (STMP)
sodium trimetaphosphate (STMP)
8
8
7785-84-4
7785-84-4
Bullock CH and Kamienski FX
Busman L.M. And Tabatabai M.A.
1972
1985
sodium trimetaphosphate (STMP)
8
7785-84-4
16th April 2012 - page 1-11
Object [title of the article]
Organism tested
Source [journal name]
Longitudinal Study of Cariostatic Effects of Sodium
Trimetaphosphate and Sodium Fluoride When Fed
Separately and Together in Diets of Rats
Rats
J. Dent. Res. 48(2): 183-191
Cariostatic effects of sodium trimetaphosphate when
fed to rats during different stages of tooth
development
Rats
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Rabbits
Hydrolysis of trimetaphosphate in soils
soils
Archs oral Biol 13: 779-786
Stauffer Western RC NTIS OTS0555931 (T-1861)
soil sci soc amer proc 49: 630-636
Katchman BJ and Smith HE
1958
Diffusion of synthetic and natural polyphosphates.
Inorganic triphosphate synthesis by muscle
adenylate kinase.
n/a
Archives of Biochemistry and Biophysics. 75: 396-402.
n/a
J biol chem. 219: 307-317
1927
toxicity of the (see substance)
rats
Biochem Z., 163():226
1961
Further observations on the effects of the oral
administration of polysodium metaphosphate in the
rat
Rats
Br. J. urol. 33: 135-140
bacteria
J. Food protection 60(5): 493-498
mice
Pharmacology and toxicology 64: 247-251
Lieberman I
sodium trimetaphosphate (STMP)
8
7785-84-4
sodium hexametaphosphate
9
68915-31-1
polysodium metaphosphate PSMP
9
10124-56-8
1956
Abelles. N
Anderson C.K. Et al
sodium polyphosphate mixture (SPG
69%)
9
68915-31-1
Loessner M.J. Et al
1997
Long-chain polyphosphates inhibit growth of
clostridium tyrobutyricum in processed cheese
spreads
sodium polyphosphate
9
68915-31-1
Ortega A. et al
1989
Treatment of experimental acute uranium poisoning
by chelating agents
sodium polyphosphate
9
68915-31-1
Maier SK, Scherer S and Loessner
MJ
1999
sodium polyphosphate
9
68915-31-1
Zaika LL, Scullen J and Fanelli JS
1997
Long-chain polyphosphate causes cell lysis and
inhibits Bacillus cereus spetum formation,
Applied and environemtal microbiology. 65(9): 3942which is dependant on divalent cations.
Bacteria: Bacillus cereus 3949
Growth Inhibition of Listeria monocytogenes by
Sodium Polyphosphate as Affected by
Polyvalent Metal Ions
bacteria
Journal of food science 62(4): 867-870
sodium hexametaphosphate (SHMP)
10
10124-56-8
Bailey DE
1974
Teratologic evaluation of FDA 73-3 sodium
hexametaphosphate in mice and rats.
sodium hexametaphosphate (SHMP)
10
10124-56-8
Brusick D
1975
sodium hexametaphosphate (SHMP)
10
10124-56-8
Bullock CH and Kamienski FX
1972
1998
sodium hexametaphosphate (SHMP)
10
10124-56-8
Kitahori Y, Konishi N, Cho M,
Yamamoto K, Nakagawa Y, Matsui E
and Hiasa Y
sodium hexametaphosphate (SHMP)
10
10124-56-8
Post F.J et al
sodium hexametaphosphate
10
10125-56-8
sodium hexametaphosphate
10
10125-56-8
sodium hexametaphosphate (SHMP)
10
10124-56-8
Mutagenic evaluation of compound. FDA 73-3,
Sodium hexametaphosphate
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
mice, Rats
NTIS PB245535: Report No: FDABF-GRAS-354
S. typhimuium,
Saccharomyces cerevisiae Litton Bionetics Inc. NTIS PB245486
Rabbits
Stauffer Western RC NTIS OTS0555931 (T-1861)
1963
Lack of carcinogenicity of sodium metaphosphate in
Fischer 344 rats.
rat
Influence of sodium hexametaphosphate on selected
bacteria
bacteria
appl. Microbiology 11(5): 430-435
Matsuoka A, Tsutsumi M &
Wantanbe T
1997
Influence of Hexametaphosphate on
Staphylococcus aureus Cytoplasmic Membrane Bacteria
J. Food Hyg. Soc. Japan. 38(6): 441-445
Matsuoka A, Tsutsumi M &
Wantanbe T
1995
Inhibitory Effect of Hexametaphosphate on the
Growth of Staphylococcus aureus
Bacteria
J. Food Hyg. Soc. Japan. 36(5): 588-594
Thomson RT
1935
Physical properties of sodium hexametaphosphate.
n/a
Analyst, 61:320-323
Publicly available published studies of which the IP Consortium has purchased a copyright copy
J Toxicol Pathol. 11:41-47
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
sodium hexametaphosphate (SHMP)
10
10124-56-8
sodium hexametaphosphate (SHMP)
sodium hexametaphosphate (SHMP)
10
10
10124-56-8
10124-56-8
sodium hexametaphosphate (SHMP)
10
10124-56-8
sodium hexametaphosphate
10
10124-56-8
Weimberg R & Orton WL
1967
1940
1994
Polyphosphate separations and chain length
characterization using minibore ion chromatography
with conductivity detection.
n/a
Journal of Chromatography A, 688: 89-95
1963
Repressible acid phosphomonoesterase and
consitutive pyrophosphatase of saccharomyces
mellis
n/a
J. Bacteriol. 86:805-813
sodium metaphosphate insoluble (IMP)
11
10361-03-2
Watanabe M, Sato S and Saito H
1975
sodium metaphosphate insoluble (IMP)
11
10361-03-2
Axmedkahob D.K.A and Xalnaev O.S.
1973
sodium metaphosphate insoluble (IMP)
11
10361-03-2
Bullock CH and Kamienski FX
1972
The mechanism of the hydrolysis of condensed
phosphates. II. The mechanism of the degradation of
long-chain polyphosphates
N/A
MZUZA8 Meditsinskii. Zhurnal Uzbekistana. 8: 90 93
?
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Rabbits
sodium metaphosphate insoluble (IMP)
11
10361-03-2
sodium metaphosphate insoluble (IMP)
11
10361-03-2
1954
sodium metaphosphate insoluble (IMP)
11
10361-03-2
Szymona M, Szymona O and Kulesza S 1962
Bone formation in normal and vitamin D-treated
rachitie rats during the administration of
polyphosphates.
The "soluble" and "insoluble" polyphosphates of
yeast.
On the occurance of inorganic polyphosphate
hexokinase in some microorganisms.
Van Wazer J R, Campanella D A
Structure and properties of the condensed
phosphates. IV. Complex ion formation in
polyphosphate solutions.
sodium metaphosphate insoluble (IMP)
11
10361-03-2
Irving J.T., Schibler D., and Fleisch H.
Katchman BJ and Van Wazar JR
Source [journal name]
Journal of chromatography A.739.717-222.
Journal of the American chemical society. 89(12): 2884 –
2890
American Water Works Association, p1471-1483
1996
Griffith EJ
Organism tested
Comparsion of polyphosphates analysis by ion
chromatography and modified end-griup titration
n/a
The preparation and properties of tetra-, penta-, hexa, hepta- and octaphosphates.
The Physiology of Sodium Hexametaphosphate.
?
Baluyot E S., and Hartford C U
K. K. Jones
Stover FS et al
Object [title of the article]
16th April 2012 - page 1-12
1966
1950
Bulletin of the Chemical Society of Japan 48(3): 896-898
MZUZA8 Meditsinskii. Zhurnal Uzbekistana. 8: 90 - 93
Stauffer Western RC NTIS OTS0555931 (T-1861)
rat
Proc. Soc. Exp. Biol. Med. 123:332-335
yeast
Biochi biophys Acta. 14: 445-446
n/a
Acta Microbiologica Polonica. 11:287-300
N/A
J Amer. Chem. Soc. 72: 655 - 663
potassium dihydrogenorthophosphate
12
7778-77-0
Sakamoto S. amd Yone Y.
1979
monopotassium phosphate (MKP)
12
7778-77-0
Bailey DE
1975
availability of phosphorus compounds as dietary
phosphorus sources for red sea bream (chrysophrys
major)
fish
Teratologic evaluation of FDA 73-65 monopotassium
phosphate in mice and rats.
mice, Rats
J. Fac. Agr. Kyushu Univ. 23, 177-184
NTIS PB245521: Report No: FDABF-GRAS-340
monopotassium phosphate (MKP)
12
7778-77-0
Kamienski FX
1971
NTIS Initial Submission: Toxicology Lab Report T1680 Regarding Toxicity Studies Including
Tripotassium Phosphate and Other Chemicals with
Cover Letter Dated 102729 Monopotassium
Phosphate Acute Oral Screen Male Rats
monopotassium phosphate (MKP)
12
7778-77-0
Brusick D
1975
Mutagenic evaluation of compound. FDA 73-65,
monopotassium phosphate granular food grade
S. typhimuium,
Saccharomyces cerevisiae Litton Bionetics Inc. NTIS PB245513
7778-77-0
Fischer W et al
1991
Molluscicidal activity of potassium to the zebra
mussel, Dreissena polymorphia; toxicity and mode
of action
Mussel
Aquatic toxicology 20(4): 219-234
1993
Dietary phosphorus requirements of juvienille
sunshine bass, Morone chrysops ♀ X M.
saxatilis ♂
fish
Aquaculture, 113 (1993) 355-363
monopotassium phosphate (MKP)
monopotassium phosphate
12
12
7778-77-0
Brown ML Jaramilloe F Jnr, Gatlin
DM III
Stauffer Chemical Company, Western Research
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
monopotassium phosphate
Study
Year
Authors
Sub ID
CAS Nr.
12
7778-77-0
Dougall DS, Curry Woods L III,
Douglass LW & Soares JH
1996
Béranger-Yvon A.et al.
monopotassium phosphate (MKP)
12
7778-77-0
1958
potassium dihydrogen phosphate
12
7778-77-0
Biggers JD and McGinnis LK
2001
monopotassium phosphate (MKP)
12
7778-77-0
Frazer BC and Pepinsky R
1953
12
7778-77-0
Object [title of the article]
Organism tested
Source [journal name]
Dietary Phosphorus Requirement of Juvenile
Striped Bass Morone saxatillis
fish
The Journal of the world aquaculture society. 27(1):
82-92
algae
Revue de Cytologie et de Biologie Végétales. XIX,2:433452
mouse
Human Reproduction. 16(1): 153-163
Quelques aspects de l'action des acides
orthophorique, pyrophosphorique et adénosinetriphosphorique sur la croissance et la
photosynthèse de chlorella pyrenoidosa chick.
Evidence that glucose is not always an inhibitor of
mouse preimplantation development in vitro
1976
X-ray analysis of the ferroelectric transition in
KH2PO4
N/A
Stimulation of Bone Formation in vivo by Phosphate
Supplementation,
dogs
1990
Glucose, glutamine and inorganic phosphate in early
pig
development of the pig embryo in vitro.
Harris W W, et al.
monopotassium phosphate (MKP)
16th April 2012 - page 1-13
Petters RM. et al.
Acta Cryst. 6:273
Calcif., Tiss. Res., 22, 85-98.
monopotassium phosphate (MKP)
12
7778-77-0
Dipotassium phosphate (DKP)
12
7778-77-0
Rana
1974
monopotassium phosphate (MKP)
12
7778-77-0
Ubbelohde AR & Woodward I
1947
monopotassium phosphate (MKP)
12
7778-77-0
West J
1930
Dipotassium phosphate (DKP)
13
7758--11-4
Bullock CH and Kamienski FX
1972
XXVI. A quantitative X-ray analysis of the structure of
potassium dihydrogen phosphate (KH2PO4)
n/a
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Rabbits
1943
The influence of the mineral composition of the
medium on the growth of planktonic algae. Part II:
The influence of the concentration of inorganic
nitrogen and phosphate phosphorus.
algae
Journal of Ecology, 31(2):109-148.
1980
Potassium Hydrogen Phopshate induced
nephropathy in the dog. Part I. Pathogenesis of
tubular atrophy
dog
Vet. Pathol. 17: 699-719
Schneider P. et al - Part II
1980
Potassium Hydrogen Phopshate induced
nephropathy in the dog. Part II. Glomerular
alterations
dog
Vet. Pathol. 17: 720-737
Elam CJ, Schneider BH and Ham
WE
1956
Experimetally produced urinary canuli in sheep Sheep
J Anim Sci 1956. 15:800-810.
N/A
Helv Chim Acta. 39:841-53
chicken
Poultry Sci. 22:72-78
n/a
Bull. Soc. Chim. France: 261-264
Chu, SP
Dipotassium phosphate (DKP)
Dipotassium phosphate (DKP)
Dipotassium phosphate (DKP)
dipotassium phosphate
13
13
13
13
7758-11-4
77
7758-11-4
7758-11-4
Schneider P. et al - Part I
Journal of Reproduction and Fertility. 89:269-275
algae
Indian
J Ecol 1(1):
Ecophysiological studies on the uptake of the pollutants,
copper, zinc and phosphate
by certain
algae1-11
Structure andthermal properties associated with
some hydrogen bonds in crystals. VII. Behaviour of
KH2PO4 and KH2AsO4 on cooling
n/a
Proceedings of the Royal Society 188 S: 358-372
Zeitschrift Fur Kristallographie. 74:306-332
Stauffer Western RC NTIS OTS0555931 (T-1861)
Dipotassium phosphate (DKP)
13
7758-11-4
Flatt R, Brunisholz G and Bourgeois J
1956
Contribution a l'étude du systéme quinaire. Ca++ K+-H+-NO3- - PO4--- -H2O
Dipotassium phosphate (DKP)
13
7758-11-4
Nowotarski JS and Bird HR
1943
Dietary calcium and phosphorus levels and the
vitamin D requirement of the Chick
Dipotassium phosphate (DKP)
13
7758-11-4
Selva L
1947
tetrapotassium pyrophosphate (TKPP)
15
7320-34-5
Racz G.J. And Savant N.K.
1972
Le system binaire: eau phosphate dipotassique
Pyrophosphate Hydrolysis in soil as influenced by
flooding and fixation
soil
soil sci soc amer proc 36: 678-682
Rats
Bul. Institute Hygenic sciences 106: 66
N/A
2nd edition John Wiley and Sons Ltd
tetrapotassium pyrophosphate (TKPP)
15
7320-34-5
Shimoji N. et al
1988
Subchronic oral toxicity study of potassium
phosphate as a preliminary to long-term
carcinogenicity studies in F344 rats
Potassium pyrophosphate,
polyphosphates and cyclophosphates
15
7320-34-5
Kulaev IS
2004
The biochemistry of Inorganic polyphosphates
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Object [title of the article]
16th April 2012 - page 1-14
Organism tested
Source [journal name]
Sub ID
CAS Nr.
potassium tripolyphosphate (KTPP)
16
13845-36-8
Lyutsko VA, Shashkova IL and Prodan
EA
1982
potassium metaphosphate (KMP)
17
7790-53-6
Gassner K.
1957
potassium metaphosphate (KMP)
17
7790-53-6
Thilo E. and Wieker W.
1957
Vibrational spectra of hydrated acid and intermediate
potassium tripolyphosphate
N/A
experiments on the metabolic behaviour of highly
condensed potassium metaphosphate
Rats
the hydrolysis of condensated phosphates in
aqueous solution
water
monoammonium phosphate (MAP)
18
7722-76-1
Brosheer JC and Anderson JF
1946
The system ammonia-phosphoric acid-water at 75° N/A
unknown, 68:902-904
1998
The effects of fire control chemicals on hatchability
of northern bobwhite quail (Colinus virginianus) and
red-winged blackbirds (Agelaius phoniceus)
University of Virginia MS Thesis.
1980
The toxicity of banded Urea or Diammonium
phosphate to corn as influenced by soil temperature,
moisture and pH
SOIL
Soil Sci Soc Am J. 44(2): 296
The effect upon hematopoeisis of variations in the
dietary levels of Calcium, Phosphorous, Iron and
Vitamin D: Two figures.
Rats
The Journal of Nutrition 16(6): 525-540
N/A
sheep
Zh Fiz Khim. 21:119-123
Am. J. Vet. Res., 32(8): 1229-1238
FISH
Uttar Pradesh J Zool. 15(2): 144-148
Fire retardant (Phos-Chek)containing
Monoammonium phosphate
diammonium phosphate (DAP)
18
18
7722-76-1
7722-76-1
Buscemi DM
Creamer FL and Fox RH
Birds
Source unknown
biochem Z., 328: 485-491
Z anorg allg chem 291: 164-185
monoammonium phosphate (MAP)
18
7722-76-1
Day HG and Stein HJ
1938
monoammonium phosphate (MAP)
monoammonium phosphate (MAP)
18
18
7722-76-1
7722-76-1
Polosin VA and Shakhporonov MI
Singer R.H. and McCarty R.T.
1947
1971
diammonium phosphate (DAP)
18
7722-76-1
Singh R et al
1995
monoammonium phosphate (MAP)
18
7722-76-1
Tenzer L, Frazer BC, Pepinsky R
1958
A neutral structure analysis of tetragonal NH4H2PO4 N/A
Acta Cryst. 11:505
Williams SN, McDowell LR,
Warnick AC, Wilkinson NS and
Lawrence LA
1991
Phosphorus concentrations in blood, milk,
feces, bone and selected fluids and tissues of
growing heifers as affected by dietary
phosphorus
Livestock Research fro Rural development. 3(2) [no
pg numbers]
Johnson WW and Finley MT
1980
Handbook of Acute Toxicity of Chemicals to Fish and
Aquatic Invertebrates.
Fish and invertebrates
monoamminium phosphate
18
Phos-chek (DAP + additives) Fire-Trol
931 (ammonium polyphosphate +
additives)
19
7783-28-0
diammonium phosphate (DAP)
19
7783-28-0
diammonium phosphate (DAP)
19
7783-28-0
Palanichamcy S., Arunachamy S and
Balasubramanian M P
Food consumption of Sarotherodon
Mossambicus (Trewaves) exposed to
sublethal concentration of diammonium
phosphate
1985
Singh HR, Anoop K, Dobriyal and
Pokhriyal RC
1985
diammonium phosphate (DAP)
19
7783-28-0
Smith JP, Lehr JR and Brown WE
1957
?
Acute Ammonium Salt Poisoning in Sheep.
Biochemical toxicity of fertiliser di-ammonium
phosphate to fish Clarias batrachus
cows
Food consumption of Sarotherodon Mossambicus
(Trewaves) exposed to sublethal concentration of
diammonium phosphate
fish
Toxicty of Diammonium Phosphate to the Hillstream
Minor Carp Barilus Bendelisis
Fish
Crystallographic properties of diammonium
phosphate, (NH4)2HPO4
N/A
Publicly available published studies of which the IP Consortium has purchased a copyright copy
United States Department of the Interior Fish and Wildlife
Service / Resource publication 137.
?
Uttar Pradesh J Zool, 5(1): 89-93
Acta Cryst. 10: 709
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
16th April 2012 - page 1-15
Object [title of the article]
Organism tested
Source [journal name]
Safety assessment of diammonium phosphate and
urea used in the manufacture of cigarettes.
CHO cells
Experimental and Toxicologic Pathology 59: 339-353.
Stavanja MS, Curtin GM, Ayres PH,
Bombick ER, Borgerding MF, Morgan
WT, Garner CD, Pence DH and
Swauger JE
diammonium phosphate (DAP)
19
7783-28-0
2008
diammonium phosphate (DAP)
19
7783-38-0
Wood
1985
diammonium phosphate (DAP)
19
7783-28-0
Yadav HN and Akela BP
1997
Lobster larvae and
Marine bioassays with lobster larvae and gammarids Gammarids
Effect of DAP toxicity on haematology of catfish
Heteropneustes fossilis (Bloch).
Fish
diammonium phosphate (DAP)
19
7783-28-0
Yadav HN, Akela BP and Kumari A
1998
Effect of DAP toxicity on certain haematological
parameters of Heteropneustes fossilis (Bloch).
1963
Environment and Ecology 16(2): 431-434
Sheep
J. Anim. Sci. 24:36-42
Sheep
J. Anim. Sci. 23: 73-77
Sheep
J. Anim. Sci. 23: 208-213
Sheep
J. Anim. Sci. 21: 523-226
diammonium phosphate (DAP)
19
7783-28-0
diammonium phosphate (DAP)
19
7783-28-0
Schaadt H, Johnson RR and
McClure KE
1966
diammonium phosphate (DAP)
19
7783-28-0
Johnson RR and McClure KE
1964
diammonium phosphate (DAP)
19
7783-28-0
Russel EL, Hale WH and Hubbert F 1962
Ruminant studies with diammonium phosphate
and urea
Adaptation to and platability of urea, biuret and
diammonium phosphate as NPN sources for
ruminants
In vitro and in vivo comparisons of the utilization
of urea, biuret and diammonium phosphate by
sheep.
Evaluation of diammonium phosphate as a
source of nitrogen for ruminants
diammonium phosphate (DAP)
19
7783-28-0
Cowman GL and Thomas O
1962
Lassiter CA, Brown LD and Keyser
D
1962
diammonium phosphate as a source of nitrogen
and phosphorous for beef cattle
Cows
An evaluation of diammonium phosphate as a
nitrogen source for ruminants
cows
diammonium phosphate
19
ammonium polyphosphates
20
14728-39-3
Aoyama M.
1975
Ammonium polyphosphate (APP)
20
68333-79-9
Bell et al
1986
ammonium polyphosphate
20
14728-39-3
McBeath et al
2006
Ammonium polyphosphate (APP)
20
68333-79-9
Metzger RJ
1980
Liquid ammonium polyphosphate (APP)
20
68333-79-9
Metzger RJ and Boyd CE
1980
Liquid ammonium polyphosphate
20
68333-79-9
Metzger RJ and Boyd CE
1980
ammonium polyphosphate,
triammonium pyrophosphate
20
14728-39-3
Sample E.C. Et al
1979
ammonium polyphosphate
20
14728-39-3
Venugopalan M.V. And Prasad R.
1989
reactions of ammonium ortho- and polyphosphate
fertilizer in soil: III effects of associated cations
Hydrolysis of ammonium polyphosphate in soils
under aerobic and anaerobic conditions
1985
Initial Submission: acute toxicity test battery for
monocalcium phosphate anhydrous with cover letter
dated 102392
Rat
monocalcium phosphate (MCP)
21
7758-23-8
Sorenson SS
Environment and Ecology 15(2): 455-459
Fish
Oltjen RR, Waller GR, Nelson AB
and Tillman AD
Effect of anti-flame treating agents on the skin
Ammonium Polyphosphate as a source of nitrogen
and phosphorous in cattle rations
Can Tech Rep Fish Aquat Sci, 0: 351-372
J. Anim. Sci. 21: 992
Mich State University Quartly Bulletin.
rats and rabbits
Nagoya Med, 20(1): 11-19
catlle
Agricultural experimental station bulletin 497: 1-15
Hydrolysis of Pyrophosphate in a Highly Calcareous
Soil: A Solid-State Phosphorus-31 NMR Study
soil
Liquid ammonium polyphosphate as a fish pond
fertilizer
FISH
soil sci soc amer proc, on line march 29
Transactions of the American Fisheries Society, 109: 563570
Liquid ammonium polyphosphate as a fish pond
fertiliser.
Liquid ammonium polyphosphate as a fish pond
fertiliser.
fish and plankton
Transactions of the American Fisheries society. 109:563570
Transactions of the American Fisheries society. 109:563570
soil
soil sci soc amer 43: 58-65
soils
biol fertil soils 8: 325-327
Fish
Publicly available published studies of which the IP Consortium has purchased a copyright copy
NTIS OTS0571950 Report No. T-12163
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
monocalcium phosphate (MCP)
monocalcium phosphate (MCP)
Study
Year
Authors
21
21
CAS Nr.
7758-23-8
7758-23-8
Sorenson SS
Sorenson SS
Object [title of the article]
16th April 2012 - page 1-16
Organism tested
Source [journal name]
1985
Initial Submission: acute toxicity test battery for
monocalcium phosphate anhydrous with cover letter
dated 102392
Rabbit
NTIS OTS0571950 Report No. T-12163
1985
Initial Submission: acute toxicity test battery for
monocalcium phosphate anhydrous with cover letter
dated 102392
Rabbit
NTIS OTS0571950 Report No. T-12163
Initial Submission: acute toxicity test battery for
monocalcium phosphate anhydrous with cover letter
dated 102392
Rabbit
NTIS OTS0571950 Report No. T-12163
Mutagenic evaluation of compound. FDA 71-81,
monocalcium phosphate
Hydrolysis of primary calcium phosphate in function
of the temperature
phosphate induced renal calcification in the rat
Bull. Sco. Roy. Sci. Liege 32(5-6): 362-365
can j physiol pharmac 57(1):92
monocalcium phosphate (MCP)
21
7758-23-8
Sorenson SS
1985
monocalcium phosphate (MCP)
21
7758-23-8
Brusick D
1975
monocalcium phosphate (MCP)
monocalcium phosphate (MCP)
21
21
7758-23-8
7758-23-8
Guillaume M.
Hitchman A.J. et al
1963
1979
monocalcium phosphate (MCP). 1hydrate
21
10031-30-8
Misra N.P. Et al
1981
monocalcium phosphate (MCP)
21
7758-23-8
monocalcium phosphate (MCP)
21
7758-23-8
Pozin M.E. Et al
1959
Sollmann T. Schettler O.H. And Wetzel
N.C.
1921
studies of chronic toxicity in albino rats IV
Rats
j pharm exp therap 17():197-225
monocalcium phosphate (MCP)
21
7758-23-8
Brown WE and Lehr JR
1959
Application of phase rule to the chemical behaviour
of monocalcium phosphate monohydrate in soils.
N/A
Soil Sci. Soc. Am. Proc. 23:7-11
Lindsay WL and Stephenson HF
1959
Nature of reactions of monocalcium phosphate
monohydrate in soils: I. The solution that reacts with
the soil.
N/A
?
S. typhimuium,
Saccharomyces cerevisiae Litton Bionetics Inc. NTIS PB245509
water
rats
interaction of monocalcium phosphate monohydrate
with water solubility and hydrolysis
soil
the hydrolysis rate of monocalcium phosphate in
aqueous solutions
water
fert news 26: 34-36
j appl chem ussr 32: 736
monocalcium phosphate (MCP)
21
7758-23-8
monocalcium phosphate (MCP)
21
7758-23-8
Jones MR, Hardwick LL, Clemens
RA
1987
Effect of calcium phosphate supplementation
on blood pressure in the wistar rat.
rat
Nutrition Research, 7:779-785
monocalcium phosphate
21
7758-23-8
Roy PK and Lall SP
2003
dietary phosphorus requirements of juvienile
haddock (Melanogrammus aeglefinus L.)
fish
Aquaculture 221 (2003) 451–468
monocalcium phosphate.
Monohydrate
21
7758-23-8
Vielma J and Lall SP
1998
Control of phosphorus homeostasis of Atlantic
salmon (Salmo salar) in fresh water.
fish
Fish Pysiology and biochemistry, 19 :83-93
N/A
Labor Higiene and Occupational Diseases 31 (12) 53.
calf
Rev Salud Anim, 10 : 261-262
rats
Pharmaceutical Research, 5 (8): 501-505
N/A
Unknown
N/A
Niels Bjerrum Selected Papers. 245-249
rats
Carcinogenesis 21(4): 783-792
Cells
drug metabolism reviews, 30(2): 339-357
In Russian, so the russians :)
monocalcium phosphate (MCP)
21
7758-23-8
monocalcium phosphate (MCP)
21
7758-23-8
1987
Alfonso et al
1988
GTPZAB (1987) Phosphoric Acid calcium salt (2:)
monohydrate. RTECS Gigiena Truda I
Professional'nye Zabolevniya.
Comunicacion Corta Intoxicacian por fosfato
dicaclcico (CaHPO4) en terneros
monocalcium phosphate (MCP)
21
7758-23-8
Behling et al
1988
monocalcium phosphate (MCP)
monocalcium phosphate (hydrated and
anhydrous),
21
7758-23-8
Belopolski et al
1940
21
7758-23-8
Bjerrum N
1949
monocalcium phosphate (MCP)
21
7758-23-8
Cohen S.M. Et al
2000
Mineral metabolism of aging female rats fed various
commercially available calcium supplements or
yoghurt
The vapour pressures of saturation solutions and
solubilities in the system
Investigations on the solubility of calcium
phosphates
Calcium phosphate containing precipitate and the
carcinogenicity of sodium salts in rats
monocalcium phosphate (MCP)
21
7758-23-8
Cohen SM
1998
Cell proliferation and carcinogenesis
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
monocalcium phosphate (MCP)
Sub ID
CAS Nr.
21
7758-23-8
Authors
Study
Year
Daabees N et al
1988
Dissolution behaviour of carbonated apatites in the
presence of some ions
1988
Chemistry Set Chemicals: An Evaluation of Their
Toxic Potential.
1972
1987
A Review of the Physiological and Pharmacological
Effects of Pyrophosphate and Diphosphonates on
Bones and Teeth.
?
Object [title of the article]
16th April 2012 - page 1-17
Organism tested
Source [journal name]
drug development and industrial pharmacy, 14(3): 18551875
Everson GE et al
monocalcium phosphate (MCP)
21
7758-23-8
N/A
Vet Hum Toxicol 30(6): 589-592
N/A
J Dent Res Supplement to No 2, 51:324-332
Gigiena I Sanitaria, 52 (12):87, 1987
fish
Br. J. Nutr:45
N/A
Industrial and engineering chemistry.7
Fleisch H and Russell RGG
monocalcium phosphate (MCP)
monocalcium phosphate (MCP)
monocalcium phosphate dihydrate
(MCP)
21
21
21
7758-23-8
7758-23-8
7758-23-8
Gigiena I Sanitaria, 52 (12):87, 1987
1935
Studies on the nutrition of salmoid fish. The
magnesium requirements of rainbow trout (Salmo
gairdneri)
Preparation and properties of mono-, di- and
tricalcium phosphates.
Lehr JR, Brown WE and Brown EH
1959
Chemical behaviour of monocalcium phosphate
monohydrate in soils.
Miller JW
1936
The physiological response of peritoneal tissue to
certain industrial and pure mineral dusts
guinea pig
Public health reports. 51(49):1677-1688
2003
Response of growing Pekin ducks to
supplementation of monobasic calcium phosphate
to low phosphorus diets
duck
Poult. Sci. 82(2):309-319.
Knox D, Cowey CB and Adron JW
1981
Larson H W E
monocalcium phosphate (MCP)
21
7758-23-8
monocalcium phosphate (MCP)
21
7758-23-8
Calcium phosphate dust
21
7758-23-8
monocalcium phosphate (MCP)
21
7758-23-8
Rodehutscord M et al
Soil Sci. Soc. Am. Proc. 23: 3-12
monocalcium phosphate (MCP)
21
7758-23-8
Rodehutscord M et al
2005
monocalcium phosphate (MCP)
21
7758-23-8
Taylor AW and Gurney EL
1965
monocalcium phosphate (MCP)
calcium phosphate [ in the system:
Ca(OH)2-H3P)4-KCl-H2O ]
21
7758-23-8
Yakovleva, Efimova, Shafranskii
1979
21
7758-23-8
Zhang J
1991
Comparative studies with three-week-old chickens,
turkeys, ducks and quails on the response in
phosphorus utilization to a supplementation of
monobasic calcium phosphate
turkey, duck
the effects of salts on the dissolution of
monocalcium phosphate
dihydromoncalcium phosphate in the x-ray therapy fo
tumours
Animal ?
Ion association in calcium phosphate solutions at
37°C.
N/A
1988
Characterization of acid-base disturbances and
effects on calcium and phosphorus balances of
dietary fixed ions in pregnant or lactating does goats
J Anim Sci 1988. 66:159-173
1964
A clinical test of addition of phosphates to the diet of
children
human
J. D. Res suppl to num 6, 43: 1150-1155
monocalcium phosphate
dicalcium phosphate (DCP)
21
22
7758-23-8
7757-93-9
Fredeen AH, DePeters EJ and
Baldwin RL
Averill H.M. And Bibby B.G.
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Poult. Sci. 82(2):309-319.
Soil Sci Soc Am J. 29:151-153
med radiol 24: 16-19
Journal of solution chemistry. 20:5 455-465
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
16th April 2012 - page 1-18
Organism tested
Source [journal name]
human
J. D. Res. 36(3): 399-402
human
J Canad Dent Asso 6:
Rabbits
Stauffer Western RC NTIS OTS0555931 (T-1861)
Sub ID
CAS Nr.
dicalcium phosphate (DCP)
22
7757-93-9
Muhler J.C.
1957
dicalcium phosphate dihydrate
22
7789-77-7
Richardson A.S. Et al
1972
dicalcium phosphate (DCP)
22
7757-93-9
Bullock CH and Kamienski FX
1972
effect on dental caries of a dentifrice containing
stannous fluoride and dicalcium phosphate
Anticariogenic effect of dicalcium phosphate
dihydrate chewing gum: result after two years
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
1970
Transformation of dibasic calcium phosphate
dihydrate and octacalcium phosphate in slightly acid
and alkaline soils
soil
soil sci soc amer proc 34: 583-587
1973
Urea phosphate and mono-ammonium
phosphate as dietary supplements for sheep
fed diets inadequate in phosphorous and
nitrogen
Sheep
J. agric. Sci. Cam. 81: 139-143
dibasic calcium phosphate dihydrate
dicalcium phosphate
22
22
7789-77-7
Bell L.C. And Black C.A.
231-826-1
Fishwick G and Hemingway RG
Energy and Phosphorus Status as Factors
Affecting Postpartum Performance
and Health of Dairy Cows
cows
Journal of Dairy Science. 64(1)
Phosphorus Reduction Through Precision
Feeding of Dairy Cattle
cows
J. Dairy Sci. 87:2314–2323
dicalcium phosphate
22
7757-93-9
Carstairs JA, Neitzel RR and Emery
RS
1981
dicalcium phosphate
22
7757-93-9
Cerosaletti PE, Fox DG and Chase
LE
2004
1986
Calcium and phosphorus requirement of swine
from weaning to market weight: I. Development
of response curves for performance
pig
Reliability of Dietary Ca and P Levels and Bone
Mineral Content as Predictors of Bone
Mechanical Properties at Various Time Periods pig
J Nutr. 116:2155-2170
G. A. Reinhart and D. C. Mahan
1986
Effect of various calcium:phosphorus ratios at
low and high dietary phosphorus for starter,
grower and finishing swine
J. Anim. Sci. 1986.63:457-466
dicalcium phosphate
22
7757-93-9
N. R. Combs, E. T. Kornegay, M. D.
Lindemann and D. R. Notter
1991
dicalcium phosphate
22
7757-93-9
Crenshaw TD
dicalcium phosphate
22
7757-93-9
Dicalcium phosphate dust (DCP)
22
7757-93-9
NTIS
1974
dicalcium phosphate (DCP)
22
7757-93-9
Bennett AC and Adams F
1976
Health hazard evaluation/toxicity determination. Arco
polymer incorporated , Monaca, Pennsylvania
N/A
Solubility and solubility product of dicalcium
phosphate dihydrate in aqueous solutions and soil
solutions.
Soil Sci Soc Am J. 40(1): 39-42
2007
The determination of retainable phosphorus, relative
biological availability, and relative biological value of
phosphorus sources for broilers
chicken
Poult. Sci. 86:857-868.
Dicalcium phosphate, Defluorinated
phosphate
22
7757-93-9
Coon CN et al
pig
J Anim Sci 1991. 69:673-681.
Publicly available published studies of which the IP Consortium has purchased a copyright copy
N/A
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
16th April 2012 - page 1-19
Organism tested
Source [journal name]
N/A
Biochem Z. 163: 646-9
N/A
J Phys Chem. 67:2853-2854
Sub ID
CAS Nr.
dicalcium phosphate (DCP)
22
7757-93-9
Domontovitch MK and Sarubina OV
1925
dicalcium phosphate (DCP)
22
7757-93-9
Greenwald I
1963
Versuche zur ermittlung loslichkeitsproducts von
dicalciumphosphat
The instability constant and hydrogen ion
dissociation of calcium hydrogen phosphate.
1970
Solubility of CaHPO4.2H2O in the system Ca(OH)2H3PO4-H2O, at 5, 15, 25, and 37.5°C. J. Res. Nat.
Bur. Stand – A.
N/A
Calcium hydrogenorthophosphate
dihydrate (DCP)
22
7757-93-9
Gregory TM et al
Journal of Research of the National Bureau of standards.
A. Physics and Chemistry. 74A(4): 461-475.
dicalcium phosphate (DCP)
22
7757-93-9
Grobben AH et al
2006
dicalcium phosphate (DCP)
22
7757-93-9
Hemingway R.G. Et al
1967
Inactivation of Transmissible Spongiform
Encephalopathy agents during the manufacture of
Dicalcium phosphate from bone.
ABSTRACT: magnesium ammonium phosphate as
a mineral supplement for growing
dicalcium phosphate (DCP)
22
7757-93-9
Johnson RJ and Karunajeewa H
1985
The effects of dietary minerals and electrolytes on
the growth and physiology of the young chick.
Chicken
J. Nutr. 115: 1680 – 1690
N/A
Poultry Sci, 47: 1659-167
chicken
Poultry Sci. 32:78-81
dicalcium phosphate dihydrate (DCP)
22
757-93-9
Lima FR et al
1995
Chemical and Physical Evaluations of Commercial
Dicalcium Phosphates as Sources of Phosphorous
in Animal Nutrition.
dicalcium phosphate, defluorinated
phosphate
22
7757-93-9
Miller MW and Joukovsky VV
1953
Availability of phosphorus from various phosphate
materials
calcium phosphate dihydrate
22
7789-77-7
Moreno EC and Osborn G
1963
Dicalcium phosphate dihydrate
22
7789-77-7
Moreno EC, Brown WE and Osborn G
1960
Hamster and mouse
Veterinary Record, 158: 361-366
lambs
Nutrition society: 24
solubility of gypsum and dicalcium phosphate
dihydrate in the system CaO-P2O5-SO3-H2O and in
soils.
solubility of dicalcium phosphate dihydrate in
aqueous systems.
Soil Sci soc Am J. 27:614-619
Soil sci Soc Am J. 24:94-98
Sur la solubilité du phosphate bicalcique dans l’eau
pure.
On the solubility of dicalcium phospahte in pure
water.
Dicalcium phosphate (DCP)
22
7757-93-9
Rindell MA
1902
dicalcium phosphate dihydrate
22
7789-77-7
Tung M.S. Et al
1985
dicalcium phosphate (DCP)
22
7757-93-9
Wallner-Pendleton E.A. Et al
1989
dicalcium phosphate
22
7757-93-9
Wilcox RA, Carlson CW, Kohlmeyer
WM and Gastler GF
1955
dicalcium phosphate dihydrate
22
7789-77-7
Zhang J
1994
dicalcium phosphate (DCP)
22
7757-93-9
Zhang J
1992
The availability of phosphorus from different sources
for poults fed practical-type diets
turkey
Unexpected pH dependence of dissolution kinetics
of dicalcium phosphate dihydrate.
Dissolution deceleration of calcium phosphate
crystals at constant undersaturation
N/A
dicalcium phosphate (DCP)
22
7757-93-9
Zhang J
1992
Interpretation of dissolution kinetics of dicalcium
phosphate dihydrate.
1972
Effect of Dietary Phosphorus on Calcium
Metabolism in Intact and Parathyroidectomized Adult
Rats
rat
dicalcium phosphate monohydrate
22
Anderson GH and Draper HH
N/A
Hydrolysis of dicalcium phosphate dihydrate in the
presence or absence of calcium fluoride
water
Toxicity of excess dicalcium Phosphate in the Diet of
Turkey Poults
turkey
N/A
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Comptes Rendus de l’Acad. Sci. 134:112-114.
J. Dent. Res. 64(1): 2-5
avian diseases 33: 375-378
Poultry Science. 34: 1017-1023
J. Phys. Chem, 98
Journal of crystal growth. 123: 59-68
Journal of Crystal Growth. 125. 251-269
the Journal of nutrition
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
dicalcium phosphate
dicalcium phosphate
Sub ID
CAS Nr.
22
7757-93-9
22
16th April 2012 - page 1-20
Authors
Study
Year
Edwards HM and Veltmann JR
1983
The Role of Calcium and Phosphorus in the Etiology
of Tibial Dyschondroplasia in Young Chicks
chicken
J Nutr. 113:1568-1575
1991
EFFECTS OF DIETARY CALCIUM, PHOSPHORUS,
CALCIUM: PHOSPHORUS RATIO AND VITAMIN K
ON PERFORMANCE, BONE STRENGTH AND
BLOOD CLOTTING STATUS OF PIGS
pig
J Anim Sci 1991. 69:646-655.
7757-93-9
D. D. Hall, G. L. Cromwell and T. S.
Stahly
1992
1972
dicalcium phosphate
22
7757-93-9
Hutcheson JP, Greene LW, Carstens
GE and Byers FM
dicalcium phosphate
22
7757-93-9
Krishinaro GVG and Draper HH
dicalcium phosphate, monosodium
phosphate
22
7757-93-9
Barton BA, Jorgensen NA & DeLuca HF 1987
tricalcium phosphate (refers by CAS No.
to ß-TCP)
23
7758-87-4
Brusick D
1976
tricalcium bis(orthophosphate)
23
7758-87-4
Ogino C. et al
1979
tricalcium bis(orthophosphate) (ß-TCP)
23
7758-87-4
Bohner M
1997
tricalcium phosphate (TCP)
24
1306-06-5
Bullock CH and Kamienski FX
Object [title of the article]
Organism tested
Effects of zeranol and two dietary levels of calcium
and phosphorus on performance, carcass and bone
characteristics, and calcium status in growing lambs sheep
Influence of Dietary Phosphate on Bone
Resorption in Senescent Mice
mice
Impact of Prepartum Dietary Phosphorus Intake on
Calcium Homeostasis at Parturition
Mutagenic evaluation of compound. FDA 75-30,
tricalcium phosphate, NF,FCC
availability of dietary phosphorus in carp and
rainbow trout
cows
Source [journal name]
J Anim Sci 1992. 70:1346-1351.
J. NUTRITION,102: 1143-1146.
J Dairy Sci 70:1186-1191
S. typhimuium,
Saccharomyces cerevisiae Litton Bionetics Inc. NTIS PB257879
fish
B. Jap. Soc. Scient. Fisheries 45(12): 1527-1532
1972
Kinetics of dissolution of ß-tricalcium phosphate.
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Journal of colloidal and interface science. 190: 37-48
Rabbits
Stauffer Western RC NTIS OTS0555931 (T-1861)
2008
and hydroxyapatite on colony formation, DNA
damage and mutagenicity.
microorganisms
Mutation Research. 625:139-144
HAP (24) (also looks at fluorinated
compounds in comparison to HAP)
24
1306-06-5
Jantova S, Theisova M, Letasiova S,
Birosova L and Palou TM
tricalcium phosphate (as ‘posture’)
24
12167-74-7
O’Connell MA et al
1989
Gastrointestinal tolerance of oral calcium
supplements
human
Clin pharm. 8: 425-427.
Ossopan’ - microcrystalline
hydroxyapaptite
24
1306-06-5
Reid IR, Hannan SF, Shooler BA and
Ibbertson HK
1986
The acute biochemical effects of four proprietary
calcium preparations.
human
Aust NZ J Med. 16:
tricalcium phosphate (TCP)
24
12167-74-4
Sasaoka K. et al
1989
an immunological study of tricalcium phosphate
supplied by three different manufacturers
guinea pigs
J. Clin. Lab. Immunol. 30: 197-202
tricalcium phosphate
24
235-330-6
Mallaiah K.V., Padma Rami Y. and
Vijaya Lakshmi M.
1981
tricalcium phosphate (TCP)
24
12167-74-4
Bano, A., Majumder, S.K.
1965
Effect of phosphorous nutrition on growth and
sporulation of Alternaria macrospora and Drechslera
rostrata
fungus
T. Castaneum, C.
pathological changes induced in insects
Cephalonica, E. Cautella
Publicly available published studies of which the IP Consortium has purchased a copyright copy
indian j. microbiol 21: 169-170
J. of Invertebrate pathology 7
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
Tricalcium phosphate, Defluorinated
phosphate rock, defluorinated
superphosphate,
Object [title of the article]
16th April 2012 - page 1-21
Organism tested
Source [journal name]
24
12167-74-7
Bird HR, Mattingly JP
1945
Nutrative evaluation of deflourinated phosphates and
other phosphorous supplements. II. Defluorinated
phosphates
chicken
hydroxyapatite (HAP)
24
1306-06-5
Boskey AL
1976
Formation of hydroxyapatite at low supersaturation.
hydroxyapatite (HAP)
24
1306-06-5
Budz JA
1988
The mechanism of dissolution of hydroxyapatite and
carbonated apatite in acidic solutions.
N/A
Journal of crystal growth. 91:490-496
HAP (Gen-OxTM – natural, HA-Usynthetic)
24
1306-06-5
Cabral da Cruz AC et al
2006
Physico-chemical characterization and
biocompatibility evaluation of hydroxyapatites
Journal of Oral Science. 48(4): 219-226
hydroxyapatite (HAP)
24
1306-06-5
Clark JS
1955
Hydroxyapatite (HAP)
24
1306-06-5
Clark LM and Gerrard WF
1938
tricalcium phosphate (TCP)
24
1306-06-5
Danneel H and Frohlich KW
1930
hydroxyapatite (HAP)
24
1306-06-5
Dutta. S., Sasisekharan V.
1982
hydroxyapatite (HAP)
24
1306-06-5
Elliott JC, Wilson RM and Dowker SEP 2002
Hydroxyapatite (HAP)
24
1306-06-5
Evans EJ
1990
Hydroxyapatite (HAP)
24
1306-06-5
Evans EJ et al
1991
hydroxyapatite (HAP)
24
12167-74-4
Fowler BO
1973
Hydroxyapatite (HAP)
24
1306-06-5
Francis MD
N/A
N/A
Solubility criteria for the existence of hydroxyapatite. N/A
The preparation of hydroxyapatite, 3[Ca3(PO4)2],
Ca(OH)2
N/A
Uber das system tricalcium phosphat und wasser
structure of DNA – binding to hydroxyapatite as a
probe
J Assoc of Agric Chem. 28:118-129
The Journal of physical chemistry. 80:1 40-45
Canadian journal of chemistry. 33:1696-1700
J Soc Chem Ind, 7: 295-297
N/A
Z. Anorg Chem 188:14-31
calf thymus DNA
N/A
Indian Journal of biochemistry and biophysics 19: 71-74
JCPDS-International Centre for Diffraction Data 2002,
Advances in X-ray analysis. 45: 172-
N/A
Biomaterials, 12: 574-576
N/A
Clinical materials, 7: 241-245
n/a
Inorganic Chemistry. 13:194-214
1965
Apatite structures
Toxicity of Hydroxyapatite in vitro : the effect of
particle size.
Studies on the Mechanisms of cell damage by finely
ground Hydroxyapatite Particles in vitro
Infrared studies of apatites. I. Vibrational
assignments for calcium, strontium and barium
hydroxyapatites utilising isotopic substitution
Solubility behaviour of dental enamel and other
Calcium Phosphates
N/A
Ann NY Acad Sci, 131(2): 694-712
fish
Can. J. Fish. Aquat. Sci. 42: 181-185
tricalcium phosphate (TCP)
24
12167-74-7
Hardy RW and Shearer KD
1985
Effect of dietary calcium phosphate and zinc
supplementation on whole body zinc concentration
of rainbow trout (Salmo gairdneri).
Dental materials which contain
tricalcium phosphate
24
12167-74-7
Heil J
1996
Genotoxicity of dental materials
N/A
Mutation Research 368: 181-194
Hydroxyapatite (HAP)
24
1306-06-5
La Mer VK
1962
N/A
J Phys Chem, 55: 973-978
tricalcium phosphate (TCP)
24
12167-74-4
Majumder S.K., Bano A.
1966
The Solubility behaviour of hydroxylapatite
reversion of the toxicity of tricalcium phosphate to
insects by Trehalose
insects
Nature 210: 1052-1053
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
Sub ID
CAS Nr.
hydroxyapatite (HAP)
24
1306-06-5
Manley MT
1993
Hydroxyapatite (HAP)
24
1306-06-5
McCarthy G
2001
Calcium phosphate biomaterials: a review of the
literature.
Biological effects of calcium hydroxyapatite crystals
in breast cancer
hydroxyapatite (HAP)
24
1306-06-5
McDowell H, Gregory TM and Brown
WE
1977
solubility of Ca5(PO4)3OH in the system Ca(OH)2H3PO4-H2O at 5, 15, 25 and 37°C.
2001
1306-06-5
Morgan M.P.
Niwa S, Sawai K, Takahashi H, Tagai
H, Ono M and Fukuda Y
Rao M.R., Venugopal J.S. And
Majumder S.K.
Rootare HM, Deitz VR and Carpenter
FG
1306-06-5
Satoh S et al
1987
calcium hydroxyapatite promotes mitogenesis and
matrix metalloproteinase expression in human
breast cancer cell lines
Experimental studies on the implementation of
hydroxyapatite in the medullary canal of rabbits.
Influence of the purity of tricalcium phosphate on its
toxicity to stored-product insects
solubility product phenomena in hydroxyapatite
water systems.
Effect of dietary tricalcium phosphate on availability
of zinc to rainbow trout
Effect of supplemental phytate and/or tricalcium
phosphate on weight gain, feed efficiency and zinc
content in vertebrae of channel catfish.
hydroxyapatite (HAP)
24
1306-06-5
hydroxyapatite (HAP)
24
1306-06-5
tricalcium phosphate (TCP)
24
12167-74-4
basic calcium phosphate (HAP)
24
tricalcium phosphate (TCP)
24
1980
1971
1962
tricalcium phosphate (TCP)
24
1306-06-5
Satoh S et al
1989
hydroxyapatite (HAP)
24
1306-06-5
Smith AN
1975
hydroxyapatite (HAP)
24
1306-06-5
Smith AN
1977
hydroxyapatite (HAP)
24
1306-06-5
Smith RN
1974
hydroxyapatite (HAP)
24
1306-06-5
Stewart BW
1976
The estimation of acid needed to obtain a saturated
solution in equilibrium with solid hydroxyapatite.
A model describing the kinetics of dissolution of
hydroxyapatite.
Incongruent dissolution and surface complexes of
hydroxyapatite
Short-term carcinogen-induced structural changes in
DNA in vivo.
24: HAP
di- and tri- Magnesium phosphate
24
1306-06-5
Taylor AW
1963
hydroxyapatite (HAP)
24
1306-06-5
Thomann JM
1990
Solubility products of di—and trimagnesium
phosphates and the dissociation of magnesium
phosphate solutions.
Kinetics of dissolution of calcium hydroxyapatite
powder. III: pH and sample conditioning effects
hydroxyapatite / TCP
24
12167-74-7
Toth JM, Hirthe WM, hubbard WG,
Brantley WA & Lynch KL
1991
Determination of the ratio of HA/TCP mixtures by xray diffraction
tricalcium phosphate
24
12167-74-7
Satoh SH, Izume K, Takeuchi T and
Watanbe T
1992
Calcium Pyrophosphate
25
14866-19-4
Bachelet CM et al
1987
calcium acid phosphate (CAPP)
25
14866-19-4
Ship I.I. And Mickelsen O.
1964
Roch-Arveiller M, Legros R, Chanaud
B, Muntaner O, Strzalko S, Thuret A,
Willoughby DA and Giroud JP
1990
Inflammatory reactions induced by various calcium
pyrophosphate crystals.
26
Organism tested
Source [journal name]
Hydroxylapatite coatings in orthopaedic surgery. 1-23
N/A
Journal of research of then Nation Bureau of Standards A.
Physics and Chemistry. 81A (2 and 3): 273- 281
human tissue cells
molecular carcinogenesis 32: 111-117
rabbit
insect (tribolium)
Life science 10(II): 1081-1088
N/A
Journal of colloid science. 17:179-206
fish
Nippon Suisan Gakkaishi. 53(7): 1199-1205
fish
Aquaculture. 80: 155-161
N/A
Journal of Colloid and Interface Science, 54:2
N/A
Journal of Colloid and Interface Science, 62:3
N/A
Journal of Colloid and Interface Science, 48:3
N/A
IARC Scientific Publications. No. 12 : 343-350
N/A
Trans Faraday Soc. 59: 1580-1584
N/A
Calcif Tissue Int. 46:121- 129.
n/a
Journal of Applied Biomaterials. 2:37-40
Effect of Supplemental Trica1cium Phosphate
on Zinc and Manganese Availability to Common
Carp
fish
Sequential study of Pleural Peritoneal and blood
cells in acute pleurisy Induced by Calcium
Pyrophosphate in the Rat.
the effects of calcium acid phosphate on dental
caries in children: a controlled clinical trial
Calcium pyrophosphate dihydrate
(monoclinic), calcium pyrophosphate
dihydrate (triclinic) and calcium
pyrophosphate anhydrous (β)
16th April 2012 - page 1-22
Nippon Suisan Gakkaishi. 58(3): 539-545
rat
Experimental Lung Research, 13:241-252
human
J. D. res suppl num 6, 43: 1144-1149
rat
Biomed and Pharmacother. 44: 467-474
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
monoclinic or triclinic calcium
pyrophosphate dihydrate crystals,
‘apatitie’ crystals (could be HAP,
fluoroapatite, chlorapatite or
bromapatite – not stated)
26
Ferric phosphate (FeP)
27
CAS Nr.
10045-86-0
Object [title of the article]
16th April 2012 - page 1-23
Organism tested
Watanabe W, Baker DG and
Schumacher HR
1992
Bullock CH and Kamienski FX
1972
Comparison of the acute inflammation induced by
calcium pyrophosphate dihydrate, apatite and mixed
crystals in the rat air pouch model of a synovial
space
chicks
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Rabbits
Source [journal name]
J Rhumatol 19(9): 1453-1457
Stauffer Western RC NTIS OTS0555931 (T-1861)
Ferric phosphate (FeP)
27
10045-86-0
Langan MA and Shaw EM
2006
Responses of the earthworm Lumbricus terrestris
(L.) to iron phosphate and metaldehyde slug pellet
formulations.
iron phosphate (FeP)
27
10045-86-0
Brusick D
1975
Mutagenic evaluation of compound FDA 73-84 Ferric
ortho phosphate white food grade, phase I
Yeast and Bacteria
NTIS
27
10045-86-0
Pennell MD et al
1976
Biological Availability of Iron Supplements for Rats,
Chicks and Humans
Rats, chicks, humans
Journal of Nutrition, 106(2): 265-274
Iron phosphate (FeP)
27
10045-86-0
Caldwell B
2001
A new low-toxicity slug control material for
strawberries.
Slug
NYS IPM program
Iron phosphate (FeP)
27
10045-86-0
Dunkel VC et al
1999
Genotoxicity of Iron Compounds in Salmonella
Typhimurium and L5178Y Mouse Lymphoma Cells
mouse
Environmental and Molecular Mutagenesis, 33: 28-41
iron phosphate (FeP)
27
10045-86-0
Edwards CA et al
2009
The relative toxicity of metaldehyde and iron
phosphate-based molluscicides to earthworms
Earthworms
Crop protection, 28: 289-294
Iron phosphate (FeP)
27
10045-86-0
Fritz JC et al
1975
Estimation of the bioavailability of iron.
iron phosphate (FeP)
27
10045-86-0
Speiser B and Kistler C
2002
Field tests with a molluscicide containing iron
phosphate
2006
Sodium iron pyrophosphate
Ferric orthophospahte
earthworms
Applied soil ecology, 34: 184-189
Journal of the AOAC. 58(5): 902-905
Slug
Crop protection 21: 389-394
Ferric phosphate (FeP) - hydrate
27
51833-68-2
Seifried HE, Seifried RM, Clarke JJ,
Junghans TB and San RHC.
Ferric phosphate (FeP)
27
10045-86-0
Prepared for the EU Commission
2002
Iron phosphate (FeP)
Iron phosphate (FeP)
27
27
10045-86-0
10045-86-0
Carter SR and Hartshorne NH
Chang SC and Jackson ML
1923
1957
A compilation of two decades of mutagencity test
resuls with the Ames Salmonella typhimurium and
L5178Y Mouse lymphoma cell mutation assays.
Review report for the active substance ferric
phosphate
The System Ferric Oxide-Phosphoric Acid – Water.
A New Phosphate
Solubility product of iron phosphate.
Ferric phosphate (FeP)
27
10045-86-0
Hazardous Substances Data Bank,
2004
Hazardous Substances Data Bank, Ferric phosphate Human
TOXNET
N/A
J Chem Soc. Unknown vol: 28-34
rat
Nutr. Metabol. 20: 222-227
Rat, bird, fish, aquatic
invertebrates, algae,
earthworms, arthropods,
human
PPBD (data base)
Rat
European Commission
Ferric phosphate (FeP)
27
10045-86-0
Jameson RF and Salmon
1954
complexes invloving tervalent iron and
orthohposphoric acid. Part III. The system ferric
oxide-phosphoric oxide-water at 25°
Ferric phosphate (FeP)
27
10045-86-0
Mahoney AW and Hendricks DG
1976
Effect of dietary iron level on efficiency of converted
food iron into haemoglobin by the anaemic rat.
Iron phosphate (FeP)
27
10045-86-0
N/A
Ferric phosphate (FeP)
27
10045-86-0
Prepared for the EU Commission
Environmental fate - Ecotoxicology - Human Health
1997 Ferric Phosphate PPDB
Review report for the active substance ferric
2002
phosphate
bacteria salmonella (ames
test), mouse lymphoma
cells
Chem. Res Toxicol. 19: 627-644
Human
European Commission
N/A
water and soil
J Chem Soc Trans 123: 2223-2233
Soil Sci Soc Am J. 21:265-269
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
16th April 2012 - page 1-24
Object [title of the article]
Organism tested
Source [journal name]
2002
Review report for the active substance ferric
phosphate
Mouse, hamster, guinea
pig
European Commission
Ridgway LP and Karnofsky DA
1952
The effects of metals on the chick embryo: toxicity
and production of abnormalities in development.
chick embryo
Ann N Y Acad Sci: 203-215
10045-86-0
Rodriguez E et al
2007
mice
Magn reson Mater Phy, 20: 27-37
10045-86-0
Rohner F et al
2007
An iron-based T1 contrast agent made of ironphosphate complexes: In vitro and in vivo studies.
Synthesis, Characterization, and Bioavailability in
Rats of Ferric Phosphate Nanoparticles
Rats
The Journal of Nutrition, 137: 614-619
J Chem soc: 2644-2650
Sub ID
CAS Nr.
Ferric phosphate (FeP)
27
10045-86-0
Prepared for the EU Commission
iron phosphate (FeP)
27
10045-86-0
Iron phosphate (FeP)
27
Iron phosphate (FeP)
27
iron phosphate (FeP)
27
10045-86-0
Salmon JE
1952
complexes invloving tervalent iron and
orthophosphoric acid. Part II. Ion-exhange studies of
solutions containing phosphate and chloride
n/a
Iron phosphate (FeP)
27
10045-86-0
Tamm L and Speiser B
2006
Provisional Evaluation of the use of "Ferramol
Schneckenkorn" in Organic Farming in Switzerland. Slugs/snails
Research Institute of Organic Agriculture (FiBL), Frick,
Switzerland
2004
A micronized, dispersible ferric pyrophosphate with
high relative bioavailability in man.
British Journal of Nutrition. 91:107-112
2000
Effects of Ascorbic acid on Interactions between
Ciprofloxacin and Ferrous Sulphate, Sodium Ferrous
Citrate or Ferric Pyrophosphate, in mice.
mice
J Pharm Pharmacol 52:397-401
2006
Salt Dual-Fortified with Iodine and Micronized
Ground Ferric Pyrophosphate Affects Iron Status but
Not Hemoglobin in Children in Cote d'Ivoire.
Human
Journal of Nutrition, 136(7): 1814-1820
Kitano K, Fukukawa T, Ohtsuji Y,
Matsuda T and Yamaguchi H
2002
Mutagenicity and DNA-damaging activity
caused by deomposed products of potassium
sorbate reacting with ascorbic acid In the
presence of Fe salt.
bacteria salmonella
(ames test)
Food and chemical toxicology 40: 1589-1594
Chow FC, Taton GF, Baulay JP, Lewis
LD, Remmenga EE and Hamar DW
1980
Effect of dietary calcium, magnesium and
phosphorous on phosphate urolithiasis in rats.
rat
Investigative Urology. 17(4): 273-276
Iron pyrophosphate (FePP)
28
10058-44-3
Fidler MC, Walczyk T, Davidsson L,
Zeder C, Sakaguchi N, Juneja LR and
Hurrel RF
Ferric pyrophosphate (FePP)
28
10058-44-3
Motoya T et al
ferric pyrophosphate (FePP)
28
10058-44-3
Iron pyrophosphate (FePP)
28
10058-44-3
dimagnesium phosphate (DMP)
29
7757-86-0
dimagnesium phosphate (DMP)
Phosphoric acid, sodium phosphates,
potassium phosphates, calcium
phosphates, monomagnesium
phosphate, dimagnesium phosphate,
diphosphates, triphosphates and
polyphosphates
trimagnesium bis(orthophosphate)
(TMP)
manganese phosphate (hureaulite)
(MMangP)
29
7757-86-0
29
7757-86-0
30
7756-87-1
34
18718-07-5
Wegmuller R et al
human
Halliwell DJ, Mackelvie ID, Hart BT and
Dunhill RH
1996
Separation and detection of condensed phosphates
in waste waters by ion chromatography coupled with
flow injection.
n/a
Analyst. 121:1089-1093.
Bullock CH and Kamienski FX
1972
Food additives in Europe 2000 - status of safety
assessments of food additives presently permitted in
the EU.
Initial submission: Primary skin irritation of sodium
hexametaphosphate, powdered, in rabbits
Rabbits
Stauffer Western RC NTIS OTS0555931 (T-1861)
2004(a)
Nasal toxicity of manganese sulphate and
manganese phosphate in young male rats following
subchronic (13 week) inhalation exposure
rats
inhalation toxicology 16(6): 481-488
Dorman D.C. Et al
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
manganese phosphate (hureaulite)
(MMangP)
Sub ID
CAS Nr.
34
18718-07-5
16th April 2012 - page 1-25
Authors
Study
Year
Object [title of the article]
Organism tested
Dorman DC et al
2004(b)
30 and 90 day inhalation exposure
rats
Rats
rats
manganese phosphate (hureaulite)
(MMangP)
34
18718-07-5
Normandin L. et al
2002
Assessment of bioaccumulation, neuropathy, and
neurobehavious following subchronic (90 days)
inhalation in Sprague-Dawley rats exposed to
manganese phosphate
manganese phosphate (hureaulite)
(MMangP)
34
18718-07-5
Viteralla D
2000
5 and 7 week inhalation exposure
Manganese phosphate (MMangP)
34
18718-07-5
Boyle FW and Lindsay WL
1985
Manganese phosphate (MMangP)
34
18718-07-5
Boyle FW and Lindsay WL
manganese III phosphate (MMangP)
34
18718-07-5
Boyle FW and Lindsay WL
1986
Soil Sci Soc Am J. 50(3): 588-
1985
Preparation, x-ray diffraction pattern and solubility
product of manganese (III) phosphate hydrate.
N/A
Soil Sci Soc Am J. 49: 758-760
Das ternare system manganophosphatephosphorsaure-wasser und die
diphosphatomanganosaure.
N/A
Z Physik Chem. 13:572-583
35
51349-94-1
Grube G and Staesche M
1927
dicopper hydroxide phosphate (CuHP)
38
12158-74-6
Huerin H and Kozicki H
1952
aluminium phosphate (MALP)
39
13530-50-2
Drinker P
Aluminium orthophosphate (TALP)
40
7785-30-7
Aluminium orthophosphate (TALP)
40
7785-30-7
Soil Sci Soc Am J. 49(3): 761-766
1953
Chimie minerale - sur les orthohposphates du cuivre.
Etude du systeme P2O5-Ocu-OH2 a 60 et 18°
N/A
Article: Dale JC and King EJ. Acute toxicity of
mineral dusts.
mice
Compt Rend 235: 52-1952
Archives of Industrial Hygiene and Occupational Medicine
Vol 7: 478-483
Kada T, Hirano K and Shirasu Y
1980
Screening of environmental chemical mutagens by
the Rec-Assay system with Bacillus subtilis
bacteria
Chem Mutagens. 6:149-173
Kanematsu N, Hara M and Kada T
1980
Rec assay and mutagenicity studies on metal
compounds
bacteria
Mutation Research .77:109-116
Rat
J. Nutr. 115:1708-1716
N/A
J Am Chem Soc. 76:5951-5956
N/A
Compt Rend. 234:1777-9
Aluminium phosphate (TALP)
40
7784-30-7
Greger JL, Bula EN and Gum ET
1985
Mineral metabolism of rats fed moderate levels of
various aluminium compounds for short periods of
time.
Aluminium orthophosphate (TALP)
40
7785-30-7
Brosheer JC, Lenfesty FA and
Anderson JF
1954
Solubility in the system aluminium phosphatephosphoric acid-water
Aluminium orthophosphate (TALP)
40
7784-30-7
Guerin H and Martin R
1952
Aluminium orthophosphate (TALP)
40
7785-30-7
Masten S
2000
Chimie minerale - sur les phosphates d'aluminium
Aluminium compounds, Review of Toxicological
Literature Abridged Final Report
Aluminium orthophosphate (TALP)
40
7785-30-7
Mooney RCL
1956
The crystal structure of aluminium phosphate and
gallium phosphate, low-cristobalite type
7785-30-7
Tsuhako M , Motooka I and Kobayashi
M
1973
Studies of the preparation and physical properties of
multivalent metal condensed phosphates. V. The
grinding of various aluminium phosphates.
n/a
40
Toxicology and applied pharmacology 183: 135-145
Diffraction patterns and solubility products of several
divalent manganese phosphate compounds.
N/A
Manganese phosphate equilibrium relationships in
soils.
SOIL
manganese hydrogen phosphate
(DMangP)
Aluminium orthophosphate (TALP)
Source [journal name]
Some human
N/A
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Acta Cryst. 9: 728
Bulletin of the Chemical Society of Japan. 46: 2343-2346
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Sub ID
CAS Nr.
40
7785-30-7
Study
Year
Object [title of the article]
Organism tested
Source [journal name]
1999
62: 37-39
COULD NOT BE
TRANSLATED
Experimental and Clinical Pharmacology. 62: 37-39
Yayt BB et al
Aluminium orthophosphate (TALP)
16th April 2012 - page 1-26
Aluminium tripolyphosphate
Aluminium metaphosphate
41
42
13939-25-8
13776-88-0
Tsuhako M , Hasegawa K, Matsuo T,
Motooka I and Kobayashi M
Van Der Meer H
1975
1976
sodium aluminium phosphate (SALP)
43
7785-88-8
Katz A.C. Et al
1984
Studies of the preparation and physical properties of
multivalent metal condensed phosphates. XI. The
preparation of various aluminium phosphates and
their thermal transformation
N/A
Acta Cryst. B25: 2423-2426
n/a
a six month dietary toxicity study of acidic sodium
aluminium phosphate in beagle dogs
dogs (beagle)
Bulletin of the Chemical Society of Japan. 48(6): 18301835
Acta Cryst. B25: 2423-2426
Fd. Chem. Toxic. 22(1): 7-9
sodium aluminium phosphate (SALP,
acidic, levair)
43
7785-88-8
Brusick D
1975
sodium aluminium phosphate (SALP)
43
7785-88-8
Pettersen J.C. Et al
1990
Mutagenic evaluation of compound. FDA 75-1.
007785-88-8, sodium aluminium phosphate (acidic) S. typhimuium,
F.C.C. grade levair
Saccharomyces cerevisiae Litton Bionetics Inc. NTIS PB254520
Twenty-six week toxicity study with KASAL in beagle
Environmental Geochemistry and Health, ISSN 0269-4042
dogs
dogs
(Print) 1573-2983 (Online), 12 ( 1-2): 121-123
43
7785-88-8
Hicks JS et al
1987
Toxicity and Aluminium concentration in bone
following dietary administration of two sodium
aluminium phosphate formulations in rat.
Aluminium bioavailability from the approved food
additive leavening agent acidic sodium aluminium
phosphate, incorporated into a baked good, is lower
than from water
Rats
Toxicology 227: 86–93
Basic Sodium Aluminium Phosphates
(SALP);
KASAL and KASAL II. These are
autogenous mixtures of alkaline sodium
aluminium phosphate and dibasic
sodium phosphate. KASAL contains
approx 6% Al and KASAL II contains
approx 13% Al.
rat
Fd chem toxic, 25(7): 533-538
sodium aluminium phosphate (SALP)
43
7785-88-8
Yokel R.A. And Florence R.L.
2006
Acidic sodium aluminium phosphate
(SALP)
43
7785-88-8
Yokel RA
2005
Al bioavailability from food
N/A
Toxicol Sci 84(1-S): 230-1
2008
Aluminum bioavailability from basic sodium
aluminum phosphate, an approved food
additive emulsifying agent, incorporated in
cheese
rat
Food Chem Toxicol. 2008 June ; 46(6): 2261–2266.
sodium aluminium phosphate
(SALP)
43
7785-88-8
Yokel RA, Hicks CL, Florence RL
sodium aluminium phosphate (SALP)
43
7785-88-8
WHO
sodium calcium polyphosphate
45
23209-59-8
sodium calcium polyphosphate
45
23209-59-8
Anon
Gomez F, Vast P, Llewellyn P and
Rouquerol F
1997
calcium sodium metaphosphate (CSM)
45
23209-59-8
Nair R.S. Et al
1992
sodium calcium polyphosphate
sodium potassium tripolyphosphate
(SKTP)
45
23209-59-8
Unknown author
1986
46
24315-83-1
1953
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
47
10163-15-2
Gotte H.
Gocke E, King MT, Eckhardt K and
Wild D
Hayashi M, Kishi M, Sofuni T and
Ishidate M
1990
1981
1988
Sodium aluminium phosphate(acidic and
mouse
basic)(WHO food additives series 1)
Initial submission: A two year inhalation toxicity
study of calcium sodium metaphosphate fiber in the
rat.
rat
dehydroxylation mechanisms of polyphosphate
glasses in relation to temperature and pressure.
n/a
Toxicity of calcium sodium metaphosphate fibre. In
vitro and in vivo degradation and clearance studies
Low fibrosarcoma incidence seen for phosphate
fiber test.
research in mammals with radioactive high polymers
phosphate markers
Mutagenicity of cosmetics ingredients licensed by
the European Communities.
Micronucleus tests in mice on 39 food additives and
eight miscellaneous chemicals.
Biodynamics Inc. Project No. 85-7802. Monsanto
Document Id No. 88-920005007.
Journal of non-Crystalline Solid. 222: 414-421
Rats
fundamental and applied tox. 19: 69-78
rat
Pesticide and Toxic Chemical News. 8
dogs
z naturforsch 8(b):173
Mutation Research. 90: 91-109.
Mouse
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Fd Chem. Toxic. 26(6): 487-500.
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
disodium fluorophosphate (SFP)
Study
Year
Authors
47
CAS Nr.
10163-15-2
Poulsen H & Ericsson Y
16th April 2012 - page 1-27
Object [title of the article]
Organism tested
Source [journal name]
1965
Chronic toxicity of dietary sodium
monofluorophosphate in growing rats, with special
reference to kidney changes
rat
Acta path. Et microbiol. Scandinav. 65:493-504
1977
Induced dominant lethal mutation and cytotoxic
effects in germ cells of drosophila melanogaster with
trenimon, PDMT and sodium monofluorophosphate. d. melanogaster
Gentae genetics,87: 67-81
Buchi R.
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
47
10163-15-2
Lim J.K. Et al
1978
LD50 in the mouse compared to the rat
mice and rats
Caries Res. 12: 177-179
disodium fluorophosphate (SFP)
47
10163-15-2
Shourie K.L. Et al
1950
preliminary studies of the caries inhibiting potential
and acute toxicity of sodium monofluorophosphate
hamster
J. D. Res 29: 529
rat
Caries Res. 24: 121-126
Drosophila melanogaster
gentae Genetics 87(): 67
disodium fluorophosphate (SFP)
47
10163-15-2
Whitford GM, Birdsong-Whitford NL
and Finidori C
1990
Acute oral toxicity of sodium fluoride and
monofluorophosphate separately or in combination
in rats.
disodium fluorophosphate (SFP)
47
10163-15-2
Buchi R.
1977
induced dominant lethal mutations and cytotoxic
effects in germ cells of Drosophila melanogaster
disodium fluorophosphate (SFP)
47
10163-15-2
Ericsson Y and Hammarstrom L
1965
The distribution in the mammal body of F18 and P32
from double-labelled Na2PO3F
rats and mice
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
47
10163-15-2
Ericsson Y, Santesson G and Ullberg S 1961
Gruninger SE, Clayton R, Chang SB
and Siew C
1988
Absorption and metabolism of the PO3F ion in the
animal body. Studies with F18, P32-labelled sodium
monofluorophosphate.
Acute oral toxicity of dentrifrice fluorides in rats and
mice.
rats, mice
disodium fluorophosphate (SFP)
47
10163-15-2
Maynard EA and Downs WL
1951
disodium fluorophosphate (SFP)
47
10163-15-2
Muhler JC, Weddle DA, Stewart JO
1955
Short-term feeding studies on sodium
fluorophosphate (Na2PO3F) and potassium
hexafluorophosphate (KPF6) in rats
Fluorine storage in rats receiving different flourines
in the drinking water at varying pH
sodium fluoride
n/a
n/a
Pindborg J
1957
The effect of 0.05 per cent dietary sodium fluoride on
the rat kidney
rat
disodium fluorophosphate (SFP)
47
10163-15-2
Ruzicka JA, Mrklaus L and Rokytova K 1974
disodium fluorophosphate (SFP)
47
10163-15-2
Setnikar I and Arigoni R
1988
Incorporation of fluoride in bones and teeth and
dental fluorosis in mice after administration of
complex fluorides
Chemical stability and mode of gastrointestinal
absorotion of sodium monoflurophosphate.
Acta physiol. Scand. 65:126-137
Arch. Oral Biol. Special Supplement. 4:160-174.
J Dent Res. 67:884
rat
Atomic Enery Project Rep. UR-200. Q. Tech. rep. US
atomic energy commision . Univ Rochester Oct 1-Dec 33:
24-26
rat
J. Dent. Res. 34:895-899
Acta pharmacol et toxicol. 13:36-45
mice
Archs oral Biol. 19: 947-950
various
Caries Res. 17 (Suppl. 1): 36-45 in: Karger S (1983)
Monofluorophosphate perspectives. Caries Research.
Journal of the European Organisation for Caries Research.
(Filename: Nijmegen caries research)
mice
Toxicity and Applied Pharmacology. 2 : 54-58
various
The science of the total environment. 43:41-61
Arzneim Forsch. 38(1): 45-49
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
47
10163-15-2
Smith FA and Hodge HC (most
important article)
Smith FA, Downs WL, Hodge HC &
Maynard EA
sodium fluorophosphate
47
10163-15-2
Smith GE
1985
disodium fluorophosphate (SFP)
47
10163-15-2
Zipkin I & Likins RC
1957
Toxicology of monoflurophosphate.
Screening of fluorine-containing compounds for
acute toxicity
Toxicity of fluoride-containing dental preparations: a
review.
Absorption of various fluorine compounds from the
gastrointestinal tract of the rat
rat
Am J Physiol. 191: 547-550
Boulétreau PH et al
2006
Fluoride exposure and bone status in patients with
chronic intestinal failure who are receiving home
parenteral nutrition.
human
Am J Clin Nutr 83:1429-1437
Jones CA et al
1988
Sodium fluoride promotes morphological
transformation of Syrian Hamster embryo cells.
hanster
Carcinogenesis 9(12): 2279-2284
Sodium monofluorophosphate (SFP)
47
10163-15-2
sodium fluoride
n/a
n/a
1983
1960
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Sub ID
CAS Nr.
Study
Year
Object [title of the article]
1967
16th April 2012 - page 1-28
Organism tested
Source [journal name]
disodium fluorophosphate (SFP)
47
10163-15-2
Stookey G.K., Hudson J.T. and Muhler
J.C.
sodium fluorophosphate (SFP)
47
10163-15-2
WHO
1982
Laboratory Studies Concerning the Effectiveness
and Safety of Various Fluoride and FluoridePhosphate Systems.
human, rat
Inorganic fluorides used in drinking water and dental
preparations
N/A
disodium fluorophosphate (SFP)
47
10163-15-2
Zipkin I & McClure FJ
1951
Complex fluorides: caries reduction and fluorine
retention in the bones and teeth of white rats
rat
Public Health Reports. 66(47): 1523-1532
phosphoric acid
48
7664-38-2
Hill WL, Faust GT and Hendricks SB
1943
Polymorphism of phosphorus oxide,
n/a
J. Am. Chem. Soc., 65: 797-804.
phosphoric acid
48
7664-38-2
Al-Ani F.Y., Al-Lami S.K.
1988
ames salmonella
Mutation research, 206():467-470
phosphoric acid
48
7664-38-2
Alkahem HF
1989
fish
J Biol Sci Res, 20(3): 537-545
Phosphoric acid
48
7664-38-2
Amato D et al
2001
Absence of mutagenic activity of acidity regulators
Effect of different acids on the freshwater fish
Aphanius dispar.
Carbonated Beverage Consumption and Bone
Fractures
N/A
Arch Pediatr Adolesc Med 155(2):200-201
Phosphoric acid
48
7664-38-2
Amato D et al
1998
Acute effects on soft drink intake on calcium and
phosphate metabolism in immature and adult rats.
rats
Rev Invest Clin 50: 185-189
human tissue cells
scand j dent res 95: 467-474
J. Dent. Res., 46(3): 503-513
phosphoric acid
48
7664-38-2
Arenholt-bindslev D. et al
1987
Toxic effects of two dental materials on human
buccal epithelium in vitro and monkey buccal
mucosa in vivo
phosphoric acid
Phosphoric acid
phosphoric acid
48
48
48
7664-38-2
7664-38-2
7664-38-2
Bonting S.L.
Brown E.H and Whitt C.D.
Bucher K et al
1952
1952
1981
the effect of a prolonged intake of phosphoric acid
and citric acid in rats
Vapour pressure of phosphoric acids.
skin irritation potential
Rats
n/a
mice
phosphoric acid
phosphoric acid
48
48
7664-38-2
7664-38-2
Caravati M
Cheremisinoff NP
1987
2000
one acute human toxicity case report
Handbook of Hazardous chemical properties
humans
N/A
dissertation
Ind. Eng. Chem. 44,3:615-618
Agents and actions, vol 11, no 5, page 515 onds
Anals of Emergency Medicine, 16:8 August 1987, page
119/904
N/A
Phosphoric acid
48
7664-38-2
Choi JH et al
1979
Blood phosphorus levels of laying hens at various
time intervals after dosing with phosphoric acid.
hens
J. Nutr. 109: 1515-1518
hens
Unknown Journal
Phosphoric acid
48
7664-38-2
Choi JH et al
phosphoric acid
48
7664-38-2
Christensen JH and Reed RB
phosphoric acid
48
7664-38-2
Cadtru F
1978
1904
phosphoric acid
48
7664-38-2
Cipollaro. M. et al
1986
phosphoric acid
phosphoric acid
48
48
7664-38-2
7664-38-2
Demerec. M., Bertani G. and Flint J.
Drahoslava Vyskocilova et al
1951
1983
phosphoric acid
48
7664-38-2
Ellgaard E.G, Gilmore III J.Y.
1984
The phosphorus excretion pattern and balance
during one egg cycle of the laying hen fed a
phosphorus deficient diet with or without a signle
dose of phosphoric acid
Density of aqueous solutions of phosphoric acid.
Measurements at 25°C
L'acide phosphorique. Son innocuite. Sea
principlaes indications en therapeutique.
sublethal pH decrease may cause genetic damage
to Eukaryotic Cell: A study on Sea Urchins and
Salmonella typhimurium
a survey of chemicals for mutagenic action on E.
Coli
workers IN RUSSIAN
effects of different acids on the bluegill sunfish,
Lepomis macrochirus rafinesque
n/a
Industrial and Engieneering chemistry. 47(6): 1277-1281
duck, rabbit, horse, guineapig, dog, human
La Presse Medicale. 74
sea urchin (embryo and
sperm) and Salmonella
typhimurium
Teratogenesis, Carciogenesis and Mutagenesis 6: 275-287
bacteria
humans
American naturalist 85(821): 119-136 (see 123)
pracov lek, 35(2):76
fish
j. Fish Biol. 25: 133-137
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Sub ID
CAS Nr.
phosphoric acid
48
7664-38-2
Fabbri L. et al
1977
phosphoric acid
48
7664-38-2
Federal register.55
1990
phosphorous acid
48
7664-38-2
Fedorencko vi et al
1991
Object [title of the article]
16th April 2012 - page 1-29
Organism tested
Chronic broncopneumopathy and pneumoconiosis in
workers employed in phosphoric acid production
human
Phosphoric acid; toxic chemical release reporting;
community right to know
n/a
threshold concentration of phosporous acid in water
?
unknown
Consumption of soft drinks with phosphoric acid as
a risk factor for the development of hypocalcemia in
postmenopausal women
The effect of 50 per cent phosphoric acid on oral soft
tissues
Cola beverage consumption induces bone
mineralisation reduction in Ovariectomized rats.
Phosphoric acid UKPID monograph. IPCS INTOX
databank.
Carbonated beverages and urinary calcium
excretion.
Some paradoxical effects in experimental
pharmacology.
Phosphoric acid
48
7664-38-2
Fernando GR et al
1999
phosphoric acid
48
7664-38-2
Forsberg C.M.
1982
Phosphoric acid
48
7664-38-2
phosphoric acid
48
7664-38-2
Garcia-Contreras F et al
2000
Harrison W N., Bradberry S M and Vale
JA
n/a
Phosphoric acid
48
7664-38-2
Heaney RP et al
2001
phosphoric acid
48
7664-38-2
1947
phosphoric acid
48
7664-38-2
Hermann
High production volume information
system(HPVIS). Phosphoric acid .
n/a
Phosphoric acid
48
7664-38-2
Hughes W.F.
1948
phosphoric acid
48
7664-38-2
Iijima S. et al
1993
phosphoric acid
Phosphoric acid
48
48
7664-38-2
7664-38-2
Ishii H. et al
Jacobs G.A
1981
1988
phosphoric acid
48
7664-38-2
Jacobs G.A., Martens M.A.
1989
Phosphoric acid
48
7664-38-2
Jacobson L. and Halmann M.
Phosphoric acid
48
7664-38-2
JECFA
1982
1992,
1995
phosphoric acid
48
7664-38-2
Kristensen P
1993
Inorganic Acid Aerosols
1956
observations on the effect of chemical configuration
on the edema-producing potency of acid, aldehydes,
ketones and alcohols
rabbits
phosphoric acid
48
7664-38-2
Larson P.S. Et al
Phosphoric acid
48
7664-38-2
Libuda L
2008
phosphoric acid
48
7664-38-2
Loden M. et al
1985
phosphoric acid
phosphoric acid
48
48
7664-38-2
7664-38-2
Malm O J
Malm OJ
1952
1952
Phosphoric acid
48
7664-38-2
Mazariegos-Ramos et al
1995
phosphoric acid
48
7664-38-2
Morley KM
1999
HPV phosphoric acid full dossier off web 22-12-08
The tolerence of rabbit cornea for various chemical
substances.
cytotoxicity of phosphoric acid on cultured mamalian
cells
Measurement of the toxicity of chemicals to the
activated sludge
Two dilutions of phosphoric acid tested on eye.
An objective method for the evaluation of eye
irritation in vivo
Polyphosphate metabolism in the blue-green alga
Microcystis aeruginosa.
Phosphoric acid prepared at the 44th JECFA
Association between long-term consumption of soft
drinks and variables of bone modeling and
remodeling in a sample of healthy German children
and adolescents.
The dermal irritancy/corrosion of 20 compounds in
acqueous solutions
On phosphates and phosphoric acid as dietary factor
in the calcium balance of man.
dietary balance calcium and P-acid
Source [journal name]
Lavoro Umano 27: 50-57
n/a
gig sanit 45():24
human
J. Clin. Epidemiol. 52(10):1007-1010.
Rats
Swed Dent J Supplement 15
human
n/a
Arch. Med. Res. 31:360-365.
Phosphoric acid UKPID monograph. IPCS INTOX
databank.
human
Am. J. Clin. Nutr. 74:343-347.
n/a
rat, sheep, rabbit, human,
S. typhimurium,
Experimental Medicine and Surgery.V (2-3):160-162.
High production volume information system(HPVIS).
Phosphoric acid .
Bulletin of The Johns Hopkins Hospital. Appendix I. 82:338349
hamster lungs cells
shigaku (odontology) 80(5): 1159-1165
micro organisms
suishitsu Odaku Kenkyu 4(4 suppl): 197-203
J Am. Coll. Toxicol. 11,6:724
rabbits
Fd. Chem. Toxic. 27(4): 255-258
algae
Journal of Plankton Research. 4,3:481-488
n/a
Various mamals and
humans
Phosphoric acid prepared at the 44th JECFA
Nordic Arbete oche Halsa 1: 7-54
j pharmac exp ther 116():119
human
Am. J. Clin. Nutr. 88:1670-1677.
Rabbits
FAO rapport E 40023 ISSN 0281-9945
human
humans
Unknown Journal
Scand J Clin Lab Invest, 5, pages 75-84
Consumption of soft drinks with phosphoric acid as
a risk factor for the development of hypocalcemia in
children: a case-control study.
human
Evaluation of the EPA exposure assessment for
phosphoric acid.
N/A
Publicly available published studies of which the IP Consortium has purchased a copyright copy
The J. Pediatr. 126(6):940-942
Regulatory toxicology and Pharmacology. 29: 309-318
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
phosphoric acid
Sub ID
CAS Nr.
48
7664-38-2
Authors
Study
Year
MsMeniman N.P.
1973
Object [title of the article]
16th April 2012 - page 1-30
Organism tested
The toxic effect of some phosphate supplements fed
to sheep
sheep
The first dissociation constant for phosphoric acid
from 0 to 50°.
Nims LF (1933)The second dissociation constant of
phosphoric acid from 20 to 50°
Phosphoric acid
condensed phosphoric acids
48
48
7664-38-2
7664-38-2
Nims LF
1934
Parks JR and Van Wazer JR
1957
Structure and properties of the condensed
phosphates –reorganization theory and some
applications
Phosphoric acid, Phosphorous pentoxide,
Phosphorous oxychloride, Phosphorous
pentachloride, Phosphorous pentasulphide.
ABSTRACT : skin irritation tests on various
concentrations of phosphoric acid
J Am Chem Soc 56: 1110-1112, J Am Chem Soc 55: 19461951
N/A
J Am Chem Soc, 79: 4890-97
various
Toxicity Review 30. HSE Books.
Rabbits
monsanto
48
7664-38-2
Payne MP, Shillaker RO and Wilson AJ 1993
phosphoric acid
48
7664-38-2
Randall D.J. And Robinson E.C.
1977
phosphoric acid
48
7664-38-2
Reinl W
1956
toxicity IN GERMAN
human , rat
phosphoric acid
phosphoric acid : red phosphorus/butyl
rubber mixture
phosphoric acid
Australian Veterinarian J. 49: 150-152
N/A
phosphoric acid
phosphoric acid ( and various non -IP
subs)
phosphoric acid ( and various non -IP
subs)
Source [journal name]
Archiv fur Toxikologie, bd 16, S 158-181
48
7664-38-2
Sigova N.V.
1983
Toxicological characteristics of phosphoric acid and
some of its chromium salts used as a binder in
refractory production.
48
7664-38-2
Sittig M.
1981
Handbook of toxic and hazardous chemicals.
n/a
Gig. Truda i Prof. Patol. v Tsv i Cher. Metallurgii, M: 65-69
Handbook of toxic and hazardous chemicals. Noyes
Publications, Park Ridge, New Jersey, USA.
48
7664-38-2
Slack A.V.
1968
Phosphoric acid (book)
n/a
Phosphoric Acid Volume I (Parts I & II) Marcel Dekker Inc,
New York
1993
whole body exposures to a phosphoric acids
aerosol: 1. Spontaneous activity effects in wild
rodent and avian species.
birds, rodents
http://aphis.usda.gov/wildlife_damage/nwrc/publi
cations/93pubs/9337.pdf
2005
Opinion of the scientific panel on dietetic products,
Nutrition and allergies on a request from the
commission related to the tolerable upper intake
level of phosphorus.
rats
The EFSA Journal 233.1-19
48
48
7664-38-2
7664-38-2
Sterner RT
The EFSA Journal 233.1-19
Phosphoric acid
48
7664-38-2
Tucker KL
2006
phosphoric acid
48
7664-38-2
Urben PG (Ed), complied by : Pitt MJ
1999
phosphoric acid
48
7664-38-2
Urben PG (Ed), complied by : Pitt MJ
1999
Colas, but not other carbonated beverages, are
associated with low bone mineral density in older
women: the Framingham Osteoporosis study.
human
Bretherick's Handbook of reactive chemical hazards.
6th Ed - vol 1.
N/A
Bretherick's Handbook of reactive chemical hazards.
6th Ed - vol 2.
N/A
Phosphoric acid
48
7664-38-2
Vanderzee CE and Quist AS
1961
The third dissociation constant of orthophosphoric
acid.
N/A
J Phys Chem 65: 118-123
phosphoric acid
48
7664-38-2
Von Brehm J. and Meijering M.P.D
1982
on the sensitivity to low pH of some selected
crustaceans (Daphnia and Gammarus, Crustacea)
Crustaceans
Arch. Hydrobiol. 95(1): 17-27
Phoshphoric acid
48
7664-38-2
Von Burg R.
1992
phosphoric acid
48
7664-38-2
Weiner M. et al
Phosphoric acid
48
7664-38-2
Whiting SJ et al
Am. J. Clin. Nutr. 84:936-942.
N/A
N/A
various
Journal of Applied Toxicology. 12(4) 301-203
1988
Toxicology Update: Phosphoric acid/phosphates.
ABSTRACT: Modified skin irritation study on 75%
phosphoric acid in a single rabbit
rabbit
?
2001
Relationship between carbonated and other low
nutrient dense beverages and bone mineral content
of adolescents
human
Nutr. Res. 21:1107-1115.
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Sub ID
CAS Nr.
phosphoric acid
48
7664-38-2
WHO
1964
Phosphoric acid
48
7664-38-2
Wyshak G
2000
phosphoric acid
48
7664-38-2
Guevelard F
1922
phosphoric acid
48
7664-38-2
Nazario G
1952
orthophosphoric acid,
pyrophosphoric acid,
metaphosphoric acid
48
7664-38-2
Gamgee A, Priestly J and Larmuth
L
1877
phosphoric acid
48
phosphoric acid
48
Townsend LD and Cheyne H
H. R. CROOKSHANK, F. E.
KEATING, EARL BURNETT, J. H.
JONES AND
R. E. DAVIS
Urea phosphate
51
Bremner JM and Douglas LA
51
Perez CB, Warner RG and Loosli
JK
Urea phosphate
Zinc phosphate
ammonium magnesium
(struvite)
ammonium magnesium
(struvite)
ammonium magnesium
(struvite)
ammonium magnesium
(struvite)
Object [title of the article]
Organism tested
Source [journal name]
WHO Food additives.24.65
Teenaged girls, carbonated beverage consumption
and bone fractures
Toxicite comparee de divers acides pour les
poissons (Epinoches)
human, rat
WHO IPCS INCHEM phosphoric acid
human
Arch. Pediatr. Adolesc. Med. 154:610-613
fish
CR Acad Sci. 175: 124-1242
?
Rev. Inst. Aldolpho, Lutz. 11: 141
n/a
Journal of Anatomy and Physiology. 11: 255
Agentes acidulantes utilizados em alimentos
On the difference in the poisonous activity of
phosphorous in ortho-, meta-, and pyrophosphoric acids
The influence of hydrogen ion concentration of
the minimum dissolved oxygen toleration of the
silver salmon, Oncorhynchus kisutch (walbum). fish
1944
Ecology. 25(4):461-466
1971
Decomposition of urea phosphates in soils.
1967
Evaluation of Urea-phosphate as a source of
nitrogen and phosphorous for ruminants
Cows and Lambs
J Animal Science. 26: 810-819
investigation of cavity-sealing abilities of zinc
phosphate
n/a
Effect of chemical and enzymatic agents on the
formation of urinary calculi in fattening steers
1960
52
13598-37-3
Trail JS and Sausen RE
1962
56
7785-21-9
Aage HK, et al
1997
56
7785-21-9
Bouropoulos NC and Koutsoukos PG
56
7785-21-9
56
cows
J Anim Sci 1960. 19:595-600.
Soil Sci Am J. 35:575-578
N/A
2000
The solubility of struvite.
Spontaneous precipitation of struvite from aqueous
solutions
J D Res. 41(3):525-536
Journal of radioanalytical and nuclear chemistry. 223(12):213-215.
N/A
Journal of Crystal Growth. 213: 381-388
Bube K
1910
Uber magnesiumammonimphosphate
N/A
Z. Anal Chem
7785-21-9
Buchanan JR et al
1994
Thermodynamics of struvite formation.
N/A
American Society of Engineers. 37(2): 617-621
56
7785-21-9
Burns JR and Finlayson B
1982
Solubility product of magnesium ammonium
phosphate hexahydrate at various temperatures.
N/A
Journal of Urology. 128: 426-427
56
7785-21-9
Ribbe PH
1969
N/A
mineralogical magazine, 37(286): 290
56
7785-21-9
Uncles RF et al
1946
N/A
Industrial and engineering chemistry. 18(11): 699-702
56
7785-21-9
Webb KM and Ho GE
1992
N/A
Water Sci Tech. 26(9-11): 2229- 2232
56
7785-21-9
Whitaker A
1968
N/A
Mineralogical magazine. 36: 820-824
56
7785-21-9
Wrigley TJ et al
1992
The decomposition of struvite
An improved computer model of struvite solution
chemistry
N/A
Talanta. 39(12): 1597-1603
21, 9
7758-23-8
Donoso-Torres
1958
Reactions of Metaphosphates in Soils
phosphate
phosphate
orthophosphate
phosphate
ammonium magnesium phosphate
(struvite)
ammonium
(struvite)
ammonium
(struvite)
ammonium
(struvite)
ammonium
(struvite)
ammonium
(struvite)
7664-38-2
16th April 2012 - page 1-31
magnesium phosphate
magnesium phosphate
magnesium phosphate
The decomposition of Struvite: further evidence
Solubility of magnesium ammonium phosphate
hexahydrate
Struvite (MgNH4PO4.6H2O) solubility and its
application to a piggery effluent problem.
magnesium phosphate
magnesium phosphate
Monocalcium phosphate, Sodium
metaphosphate, Calcium
metaphosphate
University Microfilms an Arbor Mich PhD Thesis (No Mic 59No organism, tested in soil 1192)
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
16th April 2012 - page 1-32
Authors
Study
Year
Object [title of the article]
Organism tested
Source [journal name]
Parent R.
1990
ABSTRACT: no title
Rabbits
j am coll toxicol 1: 4: 48-49
Sub ID
CAS Nr.
4, 7, 14, 21
7601-54-9
sodium phosphate'
?
?
Earl JE and Whiteman HH
2010
Evaluation of phosphate toxicity in Cope's Gray
Treefrog (Hyla chrysoscelis) Tadpoles
tadpoles
Journal of Herpetology. 44(2): 201-208
?
?
?
?
1938
?
N/A
Zh Obschch Khim. 8:1230-1231
mg phosphates
?
?
Belopolskii AP et al
1950
? (Title in Russian)
N/A
Zh Prikl Chim. 23: 823-36
1960
Metal complexing by phosphorus compounds. I. The
thermodynamics of association of linear
polyphosphates with calcium.
trisodium phosphate anhydrous, sodium
acid pyrophosphate, tetrasodium
pyrophosphate, tripotassium phosphate,
monocalcium phosphate
STPP
0, (11?), 7
7758-29-4
Irani R.R. and Callis C.F.
sodium tripolyphosphate, sodium
pyrophosphate
0, ?
7758-29-4, ?
Watanabe M
1974
sodium tripolyphosphate
0, 10
13573-18-7
Ishidate M. et al
1984
The mechanism of the hydrolysis of condensed
phosphates. I. The solvent effect on the hydrolysis
of pyro- and tripolyphosphates
primary mutagenicity screening of food additives
currently used in Japan
J. Phys. Chem. 64:1398-1407
N/A
Bulletin of the Chemical society of Japan. 47(8): 2048-2050
bacteria salmonella (ames
test)
Fd. Chem. Toxic. 22(8): 623-636
STPP, SHMP, IMP
STPP, sodium hexametaphosphate,
tetrapotassium pyrophosphate
STPP, sodium hexametaphosphate,
tetrapotassium pyrophosphate
0, 10 ,11
7758-29-4
Harold FM
1966
0, 10, 15
7758-29-4
Davis E.M. And Wilcomb M.J.
1967
0, 10, 15
7758-29-4
Davis E.M. And Wilcomb M.J.
1968
Inorganic phosphates in biology:structure,
metabolism and function,
Enzymatic degradation and assimilation of
condensed phosphates by green algae
algae
condensed phosphate degradation and assimilation
by selected blue-green algae
algae
STTP, SHMP, DSP
0, 10, 3
7758-29-4
Karb B.
1971
Effect of polyphosphates on chick embryos
0, 11, 10, 9, 7, 5
13573-18-7
Greenfield S
1975
Berenson M.M. And Temple A.R.
1975
First Edition, pp 1-202.
n/a
Detergent toxicity: effects on Esophageal and gastric
mucosa
cats
1956
Analysis of Mixtures of the Condensed Phosphates
by Ion-Exchange Chromatography; II. Mixtures of
Ortho-, Pyro-, Tri-, Tetra-, Trimeta-. And
Tetrametaphosphates and Graham’s Salt.
STPP
sodium tripolyphosphate, dipotassium
phosphate
STPP, dipotassium phosphate,
tetrasodium pyrophosphate,
0, 13
0, 13, 7,11, 8, 9
7758-29-4
STPP, tripotassium phosphate,
trisodium trimetaphosphate, trisodium
hydrogen diphosphate
Peters TV Jr and Rieman (III) Wm
0, 14, 8, 6
7758-29-4
STPP, tetrapotassium pyrophosphate
0, 15
7758-29-4
Beukenkamp J., Rieman W. and
Lindenbaum S.
Hons FM, Steward WM and Hossner
LR.
sodium tripolyphosphate,
tetrapotassium pyrophosphate
0, 15
7758-29-4
Subbarao Y.V. Et al
chicks
N/A
1986
Behavior of the condensed phosphates in anionexchange chromatograpy.
n/a
Factor Interactions and their Influence on Hydrolysis
of Condensed Phosphates in Soils
Soil
1977
Kinetics of pyro- and tripolyphosphates hydrolyses in
the presence of corn and soybean roots as
determined by NMR spectography
roots
1954
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Bacteriological Reviews: 772-794.
water res. 1: 335-350
water res. 2: 311-324
Inst. Lanwirtsch. Zool. Bienenkd. 27(5): 237-251
Analytical chemistry of the condensed phosphates,
Pergamon Press
clin. Toxicology 8(4): 399-404
Analytical Chimica Acta, 14: 131-135
Anal. Chem. 26, 3:505-512
Soil Science: 408-416.
soil sci soc amer 41: 316-318
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
sodium tripolyphosphate,
tetrapotassium pyrophosphate
sodium tripolyphosphate, monosodium
phosphate, potassium
dihydrogenphosphate, potassium
tripolyphosphate
sodium tripolyphosphate, monosodium
phosphate, trisodium phosphate,
potassium dihydrogenphosphate
Authors
Study
Year
Sub ID
CAS Nr.
0, 15
7320-34-5
Weaver J.E. And Griffith J.F.
0, 2, 12, 16
7778-77-0
Matsuzaki H. et al
0, 2, 4, 12
7558-80-7
Shibata M.A. Et al
16th April 2012 - page 1-33
Object [title of the article]
Organism tested
Source [journal name]
1969
induction of emesis by detergent ingredients and
formulations
dogs
Toxicology and applied pharmacology 14: 214-220
1999
Comparison of Various Phosphate Salts as the
Dietary Phosphorus Source on Nephrocalcinosis
and Kidney Function in Rats
Rats
J Nutr Sci Vitaminol 45: 595-608
1992
Inorganic alkalizers and acidifier under conditions of
high urinary Na+ or K+ on cell proliferation
and two-stage carcinogenesis in the rat bladder
Rats
Jpn. J. Cancer res. 83: 821-829
teratogenesis, Carciogenesis and Mutagenesis 11: 305316
sodium tripolyphosphate, monosodium
phosphate, trisodium phosphate,
potassium dihydrogenphosphate
0, 2, 4, 12
7558-80-7
Shibata M.A. Et al
1991
comparative promoting activities of phosphate salts
on rats two-stage bladder carcinogenesis under
conditions of equivalent urinary Na+ or K+ levels
STPP, monosodium phosphate,
trisodium phosphate, sodium acid
pyrophosphate
0, 2, 4, 5
7758-29-4
Bo X., Burnstock G.
1993
Triphosphate, the key structure of the ATP molecule
responsible for interaction with P2x-purinoreceptors rats
Gen. Pharmac. 24(3) 637-640
soil
soil sci soc amer proc 33: 141-144
soil
soil sci soc amer proc 33: 622-625
sodium tripolyphosphate, sodium
orthophosphate, trisodium hydrogen
diphosphate, trisodium
trimetaphosphate
0, 2, 4, 5, 6, 8
7558-80-7
Blanchar R.W., Hossner L.R.
1969
Hydrolysis and Sorption Reactions of
Orthophosphate, Pyrophosphate, Tripolyphosphate,
and Trimetaphosphate Anions Added to an Elliot
Soil
sodium tripolyphosphate, sodium
orthophosphate, trisodium hydrogen
diphosphate, trisodium
trimetaphosphate
0, 2, 4, 5, 6, 8
7558-80-7
Blanchar R.W., Hossner L.R.
1969
Hydrolysis and sorption of ortho-, pyro-, tripoly- and
trimetaphosphate in 32 midwestern soils
Bernhardt, A.M., Kunigelis S.C., Wilbur
K.M.
1985
Editha Karl-Krouper, Clayton F. Callis &
Eli Seifter
1957
Effects of phosphates on shell growth and calcium
carbonate crystal formation
stability of condensed phosphates in very dilute
solutions.
sodium tripolyphosphate, sodium
orthophosphate, trisodium phosphate,
tetrasodium pyrophosphate, sodium
hexametaphosphate
STPP, MSP, SAPP
0, 2, 4, 7, 10
7558-80-7
0, 2, 5
7758-29-4
Rats
Rangia cuneata (marine)
and Helisoma duryi
(freshwater)
n/a
Aquatic Toxicology, 7, 1-13
Industrial and Engineering Chemistry. Vol. 49, no. 12,
p2061-2062
0, 2, 5, (4?)
7758-29-4
Tsuji S. et al
1986
STPP
0, 2, 5, 13
7758-29-4
Yamane A.N. Et al
1984
The influence of rearing temperatures on the toxicity
of various environmental pollutants for Killifish
(Oryzias latipes)
fish
Inhibitory effects of laundry detergents on the growth
of freshwater algae
algae
sodium tripolyphosphate, sodium
orthophosphate, sodium acid
pyrophosphate, trisodium
trimetaphosphate, sodium
metaphosphate
0, 2, 5, 8, 9
7558-80-7
Harris R.S. Et al
1967
the effects of phosphate structure on dental caries
development in rats
Rats
J. D. Res. 46(1): 290-294
sodium tripolyphosphate, sodium
phosphate, sodium acid pyrophosphate,
graham's salt
0, 2, 5, 9, 11
231-449-2
Hahn f, Jacobi H, Seifen E
1958
Different Compatibility of orthophosphates and
polyphosphates in chronic feeding tests?
rats
Arneimittel-forschung 8():286
0, 2, 6, 7, 8, 10
7558-80-7
Bell R.N.
1947
hydrolysis of dehydrated sodium phosphates
soil
ind eng chem 39: 136-140
STPP, MSP, SAPP, sodium
tetrapolyphosphate
sodium tripolyphosphate, sodium
orthophosphate, trisodium hydrogen
diphosphate, tetrasodium
pyrophosphate, trisodium
trimetaphosphate, sodium
hexametaphosphate
Publicly available published studies of which the IP Consortium has purchased a copyright copy
J Hyg Chem esei Kagaku 32(1): 46-53
Suishitsu Odaku Kenkyu 7(9):576-582
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
sodium tripolyphosphate, monosodium
orthophosphate, tetrasodium
pyrophoshpate, sodium
hexametaphosphate
sodium tripolyphosphate, sodium
orthophosphate, trisodium
trimetaphosphate
STPP, MSP, DSP, TSP, SAPP, TSPP,
SMP, SHMP, IMP, MKP, DKP, TKP,
TKPP, KTPP, DAP, APP, MCP, DCP,
TCP/HAP, CPP, DMP, TMP, MMP, PA
STPP, MCP, DCP
Sub ID
CAS Nr.
0, 2, 7, 9
7558-80-7
0, 2, 8
0,
2,3,4,5,7,9,10,11
,12,13,14,15,16,
19,20,21,22,24,2
6,29,30,31,46,48
0, 21, 22
7558-80-7
N/A
7758-29-4
Authors
Study
Year
Kunigelis S.C. And Wilbur K.M.
16th April 2012 - page 1-34
Object [title of the article]
Organism tested
Source [journal name]
1987
The effects of inorganic phosphates on trochopore
larvae of the oyster crassostrea virginica
oyster larvae
int J invert repro and develop 12: 161-172
1967
a comparative study of the cariostatic effect of
dietary fluorides, orthophosphates and triphosphates
in osborne-mendel rats
Rats
helv odontol acta 8(1): 56
INTERNATIONAL PROGRAMME ON
CHEMICAL SAFETY WORLD HEALTH
ORGANIZATION TOXICOLOGICAL
EVALUATION OF CERTAIN
VETERINARY DRUG RESIDUES IN
FOOD WHO FOOD ADDITIVES
SERIES 17.
1982
Review: Toxicity
INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY
WORLD HEALTH ORGANIZATION TOXICOLOGICAL
EVALUATION OF CERTAIN VETERINARY DRUG
RESIDUES IN FOOD WHO FOOD ADDITIVES SERIES 17.
Integrated Pollution Prevention and
Control: Reference Document on Best
Available Techniques for the
Manufacture of Large Volume Inorganic 2006 Chemicals - Solids and Others industry. Aug
Risk Assessment guidance on prevention of
pollution from manufacture and use
American Industrial Hygiene Association Journal, 470-476
Muhlemann H.R. And Konig K.G.
?
ECB.JRC ftp://ftp.jrc.es/pub/eippcb/doc/ [Draft BREF for
LVIC-S products (2005)]
STPP, disodium phosphate, trisodium
phosphate
0, 3, 4
7758-29-4
Smyth HF et al (1969)
1969
Range Finding Toxicity Data: List VII. Acute Toxicity
and irritation data on about 200 compounds are
presented, accumulated in a continuing program for
screening potential commercial products.
Rat
sodium tripolyphosphate, trisodium
phosphate, sodium hexametaphosphate
0, 4, 10
7601-54-9
Marshall D.L., Jindal V.
1997
Microbiological Quality of Catfish Frames Treated
with Selected Phosphates
fish
j. of food protection 60(9): 1081-1083
N/A
Annual occupational hygiene.47.441-459
rats
J. Agric. Food Chem. 25(1): 128-130
N/A
(OJ L 61, 18.3.1995, p.1).
rats, mice, rabbits
Toxicite et ecotoxicite des produits de traitement des eaux
drosophila melanogaster
Environmental Health perspective 31: 59-66
STPP, TSP, TKPP
sodium tripolyphosphate, trisodium
phosphate, tetrasodium pyrophosphate,
trisodium trimetaphosphate, sodium
hexametaphosphate
0, 4, 15
7758-29-4
Lavoue et al
2003
Review.Technical, occupational health and
environmental aspect of metal degreasing with
aqueous cleaner.
0, 4, 7, 8, 10
7785-84-4
Ivey J., Shaver K.
1977
Enzymic hydrolysis of polyphosphates in the
gastrointestinal tract
STPP, pyrophophosphoric acid,
magnesium hydrogen orthophosphate,
tricalcium phosphate, monocalcium
phosphate, potassium metaphosphate,
pentapotassium triphosphate,
0, 45, 29, 24, 21,
monopotassium phosphate, trisodium
phosphate, disodium phosphate,
17, 16, 12, 4, 3,
monosodium phosphate
2
7758-29-4
STPP, PA
0, 48
7758-29-4
Anon
1995
Dr. Werner Kastner et Dr Peter GODE,
Henkel KGaA
1983
STPP, phosphoric acid
0, 48
7758-29-4
Ramel C. and Magnusson J.
sodium tripolyphosphate, Sodium
pyrophosphate
sodium tripolyphosphate, sodium acid
pyrophosphate
European Parliament and Council Directive No
95/2/EC of 20th February 1995 on food additives
other than colours and sweeteners (OJ L 61,
18.3.1995, p.1).
Toxicity via oral, sub-cutaneous, cutaneous,
intraperitoneal routes
1979
chemical induction of nondisjunction in Drosophilia
Effects of temperature and phosphate concentration
on rate of sodium pyrophosphate and STPP
hydrolysis in soil
soils
Hydrolysis of condensed phosphates – II: sterile
environment
water
0, 5
7758-16-9
Chang C. and Racz G.J.
1977
0, 5
7758-16-9
Clesceri N.L. And Lee G.F.
1965
Publicly available published studies of which the IP Consortium has purchased a copyright copy
can J soil science 57: 271-278
int. J. air Wat. Poll. 9: 743-751
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Sub ID
CAS Nr.
sodium tripolyphosphate, Sodium
pyrophosphate
0, 5
7758-16-9
Crowther J.P. And Westman A.E.R.
1954
STPP, SAPP
0, 5
7758-29-4
Gosselin RE and Megirian R
1955
STPP, SAPP
0, 5
7758-29-4
Heinke GW
1969
STPP, SAPP
0, 5
7758-29-4
Smith M.J.
1959
16th April 2012 - page 1-35
Object [title of the article]
Organism tested
Source [journal name]
the hydrolysis of the condensed phosphates
The Influence of Chain Length on The Metabolic
Fate of Condensed Phosphates
Hydrolysis of condensed phosphates in Great Lakes
Waters
Independence in hydrolysis of condensed
phosphates
water
can j chem 32: 42-48
Rat and Rabbit
water
J Pharm Exp.Ther. 114: 402-407
Internat. Assoc. Great Lakes Res., Proc. 12th Conf:766773
water
Can. J. Chem., 37: 1115-1116
Gosselin RE et al
STPP, SAPP
sodium tripolyphosphate, sodium
pyrophosphate
0, 5
7758-29-4
0, 5
7758-16-9
Savant N.K. And Racz G.J.
1972
Clinical toxicity of commerical products
hydrolysis of sodium pyrophosphate and STPP by
plant roots
0, 5, 10, n/a
7758-29-4
Seward R.A. Et al
1986
Heat-Sensitization of Salmonella by Polyphosphates bacteria
J. of food science 51(2): 471-473
0, 5, 14
7758-16-9
Blanchar R.W., riego D.
1976
tripolyphosphate and pyrophosphate hydrolysis in
sediments
soil sci soc amer proc 40: 225-229
0, 5, 7 , 12
7758-29-4
Clesceri N.L. And Lee G.F.
1965
Hydrolysis of condensed phosphates – I: non-sterile
environment
water
int. J. air Wat. Poll. 9: 723-742
0, 5, 7, 8, 19, 18,
16, 46, 15, 14,
13, 12, 17, 20, 4,
3, 2
Various
Gard
2001
Phosphoric Acids and Phosphates.
n/a
Kirk-Othmer Encyclopaedia of Chemical Technology.
phosphoric acid and phosphates Kirk-Othmar encyclopedia
2001
sodium tripolyphosphate, sodium acid
pyrophosphate, tetrasodium
pyrophosphate, trisodium
trimetaphosphate, sodium
metaphosphate, sodium
hexametaphosphate, CarbP
0, 5, 7, 8, 9, 10,
51
7758-16-9
Zipf. K..
1957
ABSTRACT: Studies on the toxicology of
polyphosphates
Mouse
Arzneimittel 7(7) : 446-447
sodium tripolyphosphate, sodium
acidpyrophosphate, tetrasodium
pyrophosphate, sodium polyphosphate
glassy
0, 5, 7, 9
7758-16-9
Akhtar S. et al
2008
Inhibitory effects of polyphosphates on Clostridium
perfringens growth, sporulation and spore outgrowth fungus
sodium tripolyphosphate, sodium acid
pyrophosphate, sodium
hexametaphosphate, calcium
trimetaphosphate
sodium tripolyphosphate, sodium
pyrophosphate, tripotassium phosphate
STPP, sodium acid pyrophosphate,
tetrasodium pyrophosphate,
monopotassium phosphate
Various
1984
sodium tripolyphosphate, sodium
acidpyrophosphate, tetrasodium
pyrophosphate, sodium polyphosphate
glassy
0, 5, 7, 9
7758-16-9
Molins R.A. Et al
1985
STPP, SAPP, STMP, SHMP
0, 5, 8, 10
7758-29-4
Green J
1950
sediments
soil science 113(1): 18-22
Food Microbiology 25: 802– 808
Effect of Poly- and Pyrophosphates on the natural
Bacteria Flora and inoculated Clostridium
sporogenes PA 3679 in cooked packaged Bratwurst bacteria
Reversion of molecularly dehydrated sodium
phosphates.
n/a
Industrial & Engineering Chemistry, 42 (8): 1542-1546
J of foof science 50: 876-880
7758-29-4
Chadiot P and Lafuma J
1962
Acute Toxicity: Therapeutic Chelatants of Use in
Nuclear Industry.
mice
0, 5, 8, 9/10
7758-29-4
Gosselin R.E. Et al
1952
metabolic acidosis and hypocalcemia as toxic
manifestations of polymeric phosphates
rats
Journal of Pharmacology and Experimental Therapeutics.
117-127.
0, 5, 9
7758-16-9
Hahn f, Jacobi h, Rummel W.
1956
ABSTRACT: chronic feeding experiments with
polyphosphates
Rats
Die Naturwissenchaften 43(23): 539-540
0, 5, 8, 10, 11
sodium tripolyphosphate, sodium
pyrophosphate, sodium metaphosphate
seeds
Review of Epidemiological Social Medicine and Public
Health. (Toxicité Aiguë Des Chélatant Thérapeutiques
Utilisables Dans L’Industrie Nucléaire. Revue
d’Epidemiologie Medecine Sociale et Santé Publique.
STPP
STPP, sodium acid pyrophosphate,
trisodium trimetaphosphate, sodium
metaphosphate / hexametaphosphate
Clinical Toxicology of Commercial Products. 5th Ed.11-121
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
STPP, TSPP
0, 7
sodium tripolyphosphate, sodium
pyrophosphate, sodium
trimetaphosphate, sodium
tetrametaphosphate
0, 7(or 5), 8
STPP
0, 7, 11, 28
STPP, TSPP, STMP, sodium acid
pyrophosphate, disodium phosphate
sodium tripolyphosphate, tetrasodium
diphosphate, sodium polyphosphate
(65% P2O5)
sodium tripolyphosphate, Tetrasodium
pyrophosphate, Graham's salt, sodium
pentapolyphosphate
STPP, trisodium trimetaphosphate
sodium tripolyphosphate, sodium
trimetaphosphate
sodium tripolyphosphate, sodium
trimetaphosphate
STPP, STMP, TSP, sodium dihydrogen
orthophosphate, sodium phosphateglass, sodium ultraphosphate
sodium tripolyphosphate, sodium
metaphosphate, sodium
hexametaphosphate
sodium tripolyphosphate, sodium
metaphosphate, sodium
hexametaphopshate
STPP, SMP, SAPP, STMP
STPP, SMP, SAPP, STMP
0,2,3,4,5,7,10, calcium acid phosphate
Study
Year
Authors
CAS Nr.
7758-29-4
Van Wazer JR, Griffith EJ and
McCullough JF
7758-29-4, 7722-885, 7785-84-4
Watanable M, Sato S and Saito H
7758-29-4
Irani R.R. and Morgenthaler W.W.
Object [title of the article]
16th April 2012 - page 1-36
Organism tested
Source [journal name]
1955
Structure and properties of the condensed
phosphates. VII. Hydrolytic degradation of pyroand tripolyphosphate
N/A
J. Am. Chem. Soc., 77: 287-291
1976
The mechanism of the hydrolysis of condensed
phosphates. IV. The hydrolysis of pyro-, tripoly-,
trimeta- and tetrametaphosphates in aqueous
organic solvents
N/A
Bulletin of the Chemical Society of Japan. 49(9): 24742478
1963
Iron sequestration by polyphosphates.
n/a
J. Am. Oil Chem. Soc. 40:283-285
J plant nutr soil sci 168: 352-358
0, 7, 8, 5, 3
7758-29-4
Torres-Dorante L.O. Et al
2005
Hydrolysis rates of inorganic polyphosphates in
aqueous solution as well as in soils and effects on P
availability
water and soil
0, 7, 9
7722-88-5
Fingerhut F., Ruf F., Lang K.
1965
resorption of the polyphosphates
rats
klin wochensch 43: 956-957
0, 7, 9, n/a
0, 8
231-767-1
7758-29-4
Schreier K. and Noller H.G.
Dick R.P. And Tabatabai M.A.
1955
1986
Metabolism of different activated polyphosphates
Hydrolysis of polyphosphates by corn roots
Rats
corn
Arch. Exper. Path. U Pharmakol. 227: 199-209
Plant and soil 94: 247-256
0, 8
7785-84-4
Gosselin R.E. Et al
1952
0, 8
7785-84-4
Kornberg S.R.
1955
the hydrolysis and excretion of polymeric phosphate Rats
tripolyphosphate and trimetaphosphate in yeast
ABSTRACTs
yeast
0, 8, 4, 2, 9, n/a
7758-29-4
El-Reweiny F.M. et al
1976
effects of condensed phosphates on plant growth
and phosphorus uptake
grass
Plant and soil 44: 1-14
0, 9, 10
68915-31-1
Cardenas J. et al
1960
action of phosphates on experimental tumors
Rats and mice
Acta pharmacol. Et toxicol. 17: 157-160
water
soil
gisaaa gigiena i sanitariya 38(9): 19-22
soil science 142(3): 132-140
soils
soil science 143(2): 97-104
microbes
Journal of food safety. 6:13-27
0, 9, 10
0, 9, 5, 8
68915-31-1
7758-29-4
Perova N.M.and Sergeev A.N.
Dick R.P. And Tabatabai M.A.
1973
1986
0, 9, 5, 8
7758-29-4
Dick R.P. And Tabatabai M.A.
1987
experimental substantiation of hygienic
standardization of sodium hexametaphopshate and
tripolyphosphate in drinking water
Hydrolysis of polyphosphates in soil
Factors affecting hydrolysis of polyphosphates in
soils
0,2,3,4,5,7,10,
calcium acid
phosphate
7758-29-4
Tompkin RB
1983
Microbial effects of phosphates
Publicly available published studies of which the IP Consortium has purchased a copyright copy
??: 180-192
Jourma; of biological cheistry
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
STPP, MSP, DSP, TSP, SAPP, TSPP,
MKP, DKP, TKP, TKPP, KTPP, DAP,
APP, MCP, DCP, TCP, CPP, DMP,
TMP, MMP, MALP, BOP, SFP, PA,
PPA, PyroPA
STPP and tetrasodium
pyrophosphate
sodium hexametaphosphate,
sodium tripolyphosphate, sodium
tetraphosphate and terasodium
pyrophosphate.
sodium hexqametaphosphate,
monopotassium phosphate,
dipotassium phosphate,
sodium hexametaphosphate, dibasic
potassium phosphate
sodium hexametaphosphate, sodium
acid pyrophosphate, disodium
phosphate
16th April 2012 - page 1-37
Authors
Study
Year
Object [title of the article]
Organism tested
Source [journal name]
Schrödter K et al
2007
physiochemical properties (pg 23)
n/a
Ullmann's Encyclopedia of Industrial Chemistry, Author's
Edition Phosphoric acid and Phosphates
Sub ID
CAS Nr.
0,2,3,4,5,7,12,13
,14,15,16,18,19,
20,21,22,24,26,2
9,30,31,39,44,47
,48,49,50
N/A
0,7
7758-29-4
Elliot P, Straka RP and Garibaldi JA 1964
Polyphosphate inhibition of growth of
Pseudomonads from poultry meat.
Bacteria
Applied microbiology.12(6):517-522
10124-96-8
Post FJ, Coblentz WS, Chou TW &
Salunkhe DK
1968
Influence of phosphate compunds on certain
fungi and their preservative effects on fresh
cherry fruit (Prunus cerasus, L.)
fungi
Applied microbiology. 16(1): 138-142
man
Nutrition Research, 4:371-379
rats
j. Nutrition 69: 419-428
10, 0, 7
Steinhardt Bour NJ et al
10, 12, 13
68915-31-1
10, 13
68915-31-1
1984
Dymsza H.A., Reussner G.Jr, Thiessen
Jr
1959
Effect of level and form of phosphorous and level of
calcium intake on Zinc, Iron and Copper
bioavailability in man.
effect of normal and high Intakes of
Orthophosphates and metaphosphates in Rats
K. G. König, Th. M. Marthaler & H. R.
Mühlemann
10, 5, 3
10124-56-8
1961
rat
Batra S.C.
sodium hexametaphosphate, sodium
acid pyrophosphate, trisodium
phosphate, disodium phosphate, STPP
sodium hexametaphosphate,
tetrasodium pyrophosphate, sodium
acid pyrophosphate, disodium
phosphate
Sodium hexametaphosphate and
calcium hexametaphosphate
sodium metaphosphate insoluble,
sodium hexametaphosphate
sodium metaphosphate insoluble,
sodium hexametaphosphate
10, 5, 4, 3, 0
10124-56-9
FDA
10, 7, 5, 3
The ionisation behaviour of some poly (meta)
phosphates used in food products.
n/a
J. Food Sci. 30:441-444
- Dietary Supplements [Reserved] Subpart G Sequestrants, 461.
10124-56-10
Food and Drug Administration, HHS Subpart F
10, 9
10124-56-11
Tibdall C.S. et al
1952
11, 10
10361-03-2
Terrey H.
1937
ABSTRACT: mechanisms responsible for the acute
toxicity of a phosphate glass
Inorganic Chemistry 1. The metaphosphates and
polyphosphates of sodium.
1950
Structure and properties of the condensed
phosphates. III. Solubility fractionation and other
solubility studies.
J Amer. Chem. Soc. 72: 647 - 655.
Final Report on the Safety Assessment of Sodium
Metaphosphate, Sodium Trimetaphosphate and
Sodium Hexametaphosphate,
International Journal of Toxicology, 20(Suppl. 3):75-89;
11, 10
10361-03-2
sodium metaphosphate insoluble,
sodium hexametaphosphate, trisodium
trimetaphosphate
11, 10, 8
10361-03-2
sodium metaphosphate insoluble,
monosodium phosphate, disodium
phosphate,
11, 2, 3
10361-03-2
monopotassium phosphate, STPP
12, 0
7778-77-0
12, 13
12, 13
potassium dihydrogenphosphate,
dipotassium hydrogenorthophosphate
monopotassium phosphate,
dipotassium phosphate
1965
Van Wazer J R
CIR Epxert Panel (2001),
Zemel MB and Bidari M
Rats
fed proc 11(1): 162
n/a
Ann Reports Progr Chem, 34 (SUPPL: ref topley): 115-122
1983
Zinc, Iron and Copper Availability as Affected by
Orthophosphates, Polyphosphates and Calcium.
Samanidou V.
1990
mobilisation of heavy metals from river sediments of
northern Greece by complexing agents
rivers
7778-77-0
Sirova MA and Loeb LA
1976
7778-77-0
Torriani A
1960
Infidelity of DNA synthesis in vitro: screening for
potential metal mutagens or carcinogens
Influence of inorganic phosphates on enzyme
formation in E.coli
rat
Journal of Food Science, 48: 567-571
Water, air and soil pollution 52: 217-225
Science. 194(4272): 1432-1436
Bacteria
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Biochem. Biophys. Acta, 38:460-479
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
monopotassium phosphate,
dipotassium phosphate,
monosodium phosphate, disodium
phosphate
potassium dihydrogenphosphate
(KH2PO4), potassium tripolyphosphate
Sub ID
CAS Nr.
12, 13, 2, 3
7778-77-0
Authors
Study
Year
Kalashnikova NA & Rodenvich
Object [title of the article]
Organism tested
Source [journal name]
1970
Effect of phosphates on phophatase synthesis
by the culture Aspergillus awamori strain 22
n./a
Prikl Biokhim Mikrobiol. 6: 516-519
Biosci. Biotechnol. Biochem 65(4): 928-934
Trans Faraday Soc, 63: 335-340
12, 16
7778-77-0
Matsuzaki H. et al
2001
Greater effect of dietary potassium tripolyphosphate
than of potassium dihydrogenophosphate on the
nephrocalcinosis and proximal tubular function in
female rats from the intake of a high-phosphorus
diet
rats
12, 16
7778-77-0
Miller G and Porter AS
1967
Activity Coefficients of Some Polyphosphates in
Aqueous Solution.
1927
Das quaternare system K2O-NH3-P2O5-H2O bei 0°
und 25°
N/A
Z Physik Chem. 127:71-92
1956
Zur Chemie der kondensierten Phosphate.
Chem. Technol., 8:251-270
Potassium dihydrogen orthophosphate,
Sodium and potassium pyrophosphate,
Potassium triphosphate, Potassium
trimetaphosphate
monopotassium phosphate,
monoammonium phosphate
16th April 2012 - page 1-38
12, 18
7778-77-0, 7726-861
Janecke E
N/A
Thilo E.
potassium dihydrogen orthophosphate,
disodium dihydrogenorthophosphate
12, 2
7778-77-0
Silverberg SJ et al
monopotassium phosphate ,
monosodium phosphate
monopotassium phosphate ,
monosodium phosphate
potassium dihydrogen phosphate and
disodium hydrogen phosphate
12, 2
7778-77-0
1972
The Effect of Oral Phosphate Administration on
Major Indices of Skeletal Metabolism in Normal
Subjects.
A nomograph for the hydrolytic degradation of
pyrophosphates and tripolyphosphates,
Effect of phosphate supplements on soft-tissue
calcification and bone turnover.
1992
Methods for Differentiated Determination of
Orthophsophate, Condensed Phosphates and
Polyphosphate
1975
Effect of dietary Ca and Cd level of pregnant rats on
reproduction and on Dam and progeny tissue
Mineral concentration (38606)
Rats
Proceedings of the soc. For exp. Biology and medicine
148: 665-668
1978
effect of dietary Ca and P levels from 40 to 100
kg bodyweight on weight gain and soft tissue
mineral concentrations.
Pigs
Journal of animal science. 46(3): 686-691
1960
A Fine-Structure Genetic and Chemical Study of the
Enzyme Alkaline Phosphatase of E.coli.
E.coli
unknown
1986
Griffith EJ,
12, 2
7778-77-0
12, 2
7778-77-0
1959
Jowsey J and Balasubramaniam P
monopotassium phosphate, disodium
pyrophosphate, sodium
tripolyphosphate, (NH4)6P4O13 (Hexaammonium tetraphosphate), Sodium
phosphate Glass Type, 5, 15, 25, 35,
45, 65, 75
12, 2, 0
potasium phosphate, dicalcium
phosphate
monopotassium phosphate,
dicalcium phosphate
12, 22
12, 22
7778-77-0
7757-93-9
7778-77-0
Mussig-Zufica VM and Jekel M
Pond W.G. And Walker E.F.
Pond WG, Walker EF and Kirtland
D
human
Journal of Bone and Mineral Research, 1(4): 383-388
Industrial and Engineering Chemistry, 51: 240.
Clinical Science. 42: 289-299
N/A
Z Wasser-Abwasser-Forsch, 25: 353-356
Garen A and Levinthal C
dipotassium phosphate, sodium acid
pyrophosphate
12, 5
7757-93-9
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Dipotassium phosphate, monocalcium
phosphate, dicalcium phosphate,
copper (II)-hydroxyphosphate,
tetrasodium pyrophosphate
Study
Year
Authors
CAS Nr.
7758-11-4, 7758-238, 7757-93-9,
12158-74-6, 772213, 21, 22, 38, 7
88-5
Duc-Maugé C
Object [title of the article]
Organism tested
Source [journal name]
1959
Structure de l'ion PO43- dans l'anhydride
phosphorique et les phosphates métalliques
N/A
Bull Soc Chem France: 1032-1042
1981
Contribution to the phosphate-induced nephropathy
in the dog. Comparative light and electron
microscopic investigations on the proximal tubule
after oral application of K2HPO4, Na2HPO4, KCl
and NaCl.
1976
Ecological and nutritional studies on Dinobryon
Ehrenb.: Seasonal periodicity and the phosphate
toxicity problem.
Schneider P, Ober KM and Uerberberg
H
dipotassium phosphate, disodium
phosphate
13, 3
7758-11-4
Lehman JT
dipotassium phosphate, disodium
phosphate
TKP, MSP, SAPP
potassium pyrophosphate,
pyrophosphoric acid
monoammonium phosphate,
tripotassium phosphate, disodium
phosphate, monosodium phosphate
monoammonium phosphate,
diammonium phosphate
7758-11-4
14, 2, 5
7778-53-2
Wallen IE et al
1957
15, 50
7320-34-5
Gilliam J.W.
1970
18, 19
monoammonium phosphate, disodium
phosphate
Various
13, 3
18, 14, 3, 2
7722-76-1
JECFA 59th
7722-76-1, 7783-280
Ross WH, Mertz AR & Jacob KD
2002
18, 2
7722-76-1
various
diammonium orthophosphate,
ammonium polyphosphate
diammonium phosphate, ammonium
polyphosphate
Stream Pollution, Toxicity to Gambusia affinis of
certain pure chemmicals in turbid water.
Hydrolysis and uptake of pyrophosphate by plant
roots
Experimental pathology 19: 53-65
dinobryon
Limnology and Oceanography, 21(5): 646-658
fish
Sewage and industrial wastes, 29(6): 695-711
plants
soil sci soc amer proc 34: 83-86
n/a
Ammonium dihydrogen phosphate prepared at the 27th
JECFA (1983) published in 1983 and 1992. Revised at the
59th JECFA (2002).
n/a
Industrial and Engieneering chemistry. 21(3): 286-288
1929
Phosphoric acid prepared at the 59th JECFA
Preparation and properties of the ammonium
phosphates
1954
Fazekas IG (1954) Vergößerung der Nebenschilddrüsen
? durch einfach acidotische Verbindungen. Enlargement of parathyroid glands by simple acidic compounds.
Virchows Archiv 324: 531-542
Fazekas IG
19, 18, 16, 15,
14, 13, [13, 11,
10, 7, 5, 3, 2],
12, 10, 5 8, 5, 4,
3, 2
16th April 2012 - page 1-39
Furia T E
1972
Handbook of Food Additives
N/A
Handbook of food additives.CRC
1975
soil
soil sci soc amer proc. 39: 1085-1088
1977
reaction products of polyphosphates and
orthophosphates with soils and influence on uptake
of phosphorus by plants
Chemical forest fire retardants: acute toxicity to five
freshwater fishes and a Scud
fish and scud
us fish wildlife serv tech pap 91: 1-8
19, 20
7783-28-0, 1472839-3
Subbarao Y.V. And Ellis R.
7783-28-0, 1472839-3
Johnson W.W., Sanders H.O.
diammonium orthophosphate,
ammonium polyphosphate
19, 20
7783-28-0, 1472839-3
Khasawneh F.E. Et al
1974
reactions of ammonium ortho- and polyphosphate
fertilizer in soil: I Mobility of Phosphorus
soils
soil sci soc amer proc 38: 446-451
diammonium orthophosphate,
ammonium polyphosphate
19, 20
7783-28-0, 1472839-3
Khasawneh F.E. Et al
1979
reactions of ammonium ortho- and polyphosphate
fertilizer in soil: II Hydrolysis and reactions with soil
soil
soil sci soc amer proc 43: 52-58
1966
Pyrophosphate as a source of phosphorus for plants
II. Hydrolysis and initial uptake by a barley crop.
1938
Lead poisoning. Newer concepts in treatment.
19, 20
Sutton C.D., Gunary D. and Larsen S.
diammonium orthophosphate,
ammonium polyphosphate
sodium phosphate, lead phosphate
19, 20
2 (?)
7783-28-0, 1472839-3
7558-80-7
Gray I and Greenfield I
Soil Sci., 101(): 199-204
human
Publicly available published studies of which the IP Consortium has purchased a copyright copy
New York State Journal of Medicine. 38(20): 1313-1319
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
16th April 2012 - page 1-40
Study
Year
Object [title of the article]
Organism tested
Source [journal name]
Rats
Laboratory animals 23: 313-318
Sub ID
CAS Nr.
sodium dihydrogen phosphate
2,
7558-80-7
Ritskes-Hoitinga J., Lemmens A.G.
And Beynen A.C.
1989
Nutrition and kidney calcification in rats
Anhydrous sodium dihydrogen
orthophosphate NaH2PO4
2, (3)
7558-80-7
Brewer H.E. Et al
1970
A clinical study concerning the anticariogenic effects
of NaH2PO4-enriched breakfast cereals in
institutionalized subjects: results after two years
human
J. Amer. Dent. Assoc. 80: 121-124
1994
Purification and Characterization of an
Exopolyphosphatase from Saccharomyces
cerevisiae.
n/a
The Journal of Biological Chemistry 269(35): 22198-22204.
Lorenz B et al
monosodium phosphate (MSP), sodium
tripolyphosphate (STPP)
2, 0
7558-80-7
sodium phosphate, sodium
hexametaphosphate, monosodium
phosphate
2, 10, 8
7558-80-7
Borenstein M.K. And Schwartz C.
1948
The effect of the complex-forming amorphous
sodium phosphates on the calcium retention of rats
Rats
J Nutr. 36: 681-694
Anhydrous sodium dihydrogen
orthophosphate NaH2PO4,
monopotassium phosphate,
dipotassium phosphate
2, 12, 13
7558-80-7
Handelman S.L., Kreinces G.H.
1972
Effect of phosphate and pH on Streptococcus
mutans acid production and growth
bacteria
J. Dent. Res. 52(4): 651-657
1980
Mode of Action of Pharmacological Doses of
Cholecalciferol during Parturient Hypocalcemla
In Dairy Cow.
cows
J Nutr. 110:1589-1596
Poult. Sci. (2004) 83:1572-1579.
monosodium phosphate,
monoammonium phosphate
2, 18
7558-80-7
Reinhardt TA & Conrad HR
Sodium dihydrogen phosphate, Calcium
sodium magnesium phosphate,
Calcium
hydrogenorthophosphate/Calcium
dihydrogenorthophosphate, Calcium
bis(dihydrogenorthophosphate),
Calcium-sodium-phosphate
monosodium phosphate, disodium
phosphate
sodium phosphate monobasic, sodium
phosphate dibasic
monosodium phosphate (75% of the
mixture), disodium phosphate (25% of
mixture)
sodium dihydrogen phosphate,
disodium phosphate, trisodium
trimetaphosphate
monosodium phosphate, disodium
phosphate, calcium phosphate
sodium dihydrogen orthophosphate,
disodium phosphate, trisodium
phosphate, phosphoric acid
2, 21, 22,23
7558-80-7
Wendt P et al
2004
Investigations on the availability of inorganic
phosphate from different sources with growing white
Pekin ducks
Pekin duck
2, 3
7558-80-7
Abelin. J. Kobori. B
1927
effect of sodium phosphate on basal metabolism
rats
Biochem Z., 180():211-217
2, 3
7558-80-7
Haut L.L. Et al
1980
Renal toxicity of phosphate in rats
rats
Kidney international 17: 722-731
1974
ABSTRACT: The clinical effect of phosphateenriched breakfast cereals on dental care incidence
in adolscent children
human
2, 3
7558-80-7
Rowe N.H. Et al
J. D. Res spec issue, 53: 605
2, 3, 0
7558-80-7
Peterson J.K.
1969
ABSTRACT: North Dakota field test of cariostatic
effect of 1% sodium dihydrogen phosphate and
disodium hydrogen phosphate added to
presweetened breakfast cereals
2, 3, 21
7558-80-7
Goodman and Gliman
1996
The Pharmacological basis of therapeutics
2, 3, 4, 48
7558-80-7
MacKay E.M. And Olivier J.
1935
renal damage following the ingestion of a diet
containing an excess of inorganic phosphate
1963
Viscometric studies of solutions of sodium
phosphates, graham salts and vanadium-containing
graham salt
N/A
Viscosities of sodium phosphates and grahams salts. 36(3)
1918
Toxicity of phosphates, in relation to blood
calcium and tetany
Journal of Pharmacology and Experimental Therapeutics.
10:105
sodium dihydrogenorthophosphate,
disodium hydrogenorthophosphate,
trisodium orthophosphate, tetrasodium
pyrophosphate, sodium
tripolyphosphate, sodium
polyphosphate
2, 3, 4, 7, 0, 9
monosodium phosphate, disodium
phosphate, phosphoric acid
2, 3, 48
7558-80-7, 7558-794, 7601-54-9, 772288-5 7758-29-4,
68915-31-1,
Nakagaki M, Ohashi S and Minato F
7558-80-7
Binger C
human
J. D. Res. 1308
The Pharmacological basis of therapeutics. 9th Edn.
Goodman & Gilmans
rats
j. exp. Med. 61: 319
dog
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Complex sodium phosphate and
trisodium phosphate included in the
light duty liquid cleaner and granular
laundry detergent
Authors
Study
Year
Object [title of the article]
Organism tested
Source [journal name]
1988
In vitro methods for estimating eye irritancy of
cleaning products phase I: Preliminary assessment
rabbit eye
N/A
Osterburg RE
1977
Potential biological hazards of commercially
available cleansers for dentures.
N/A
Journal of Toxicology and Environmental Health, 3: 969977
Datta P.K. Et al
1962
Biological effects of food additives
rats
Sci. Food Agric. 13: 556-566
1953
N/A
J Am Chem Soc 75:5794-5797
1959
The system H2O-NaPO3
Further tests on the tolerability of phosphates
following chronic application
rats
Arneimittel-forschung 9():501
Knabel SJ, Walker HW & Hartman
PA
1991
Inhibition of Asperigillus flavus and selected
Gram-positive bacteria by chelation of essential
metal cations by polyphosphates.
Bacteria
JOURNAL OF FOOD PROTECTION, 54
Data book of chromosomal aberration test in vitro
Sub ID
CAS Nr.
2, 4
7558-80-7
Booman KA et al
2, 4
7558-80-7
2, 5
7558-80-7
monosodium phosphate, trisodium
phosphate
disodium phosphate, sodium
pyrophosphate
sodium dihydrogenorthophosphate,
sodium acid pyrophosphate
sodium phosphate, sodium acid
pyrophosphate, graham's salt
monosodium phosphate, sodium
acid pyrophosphate, tetrasodium
pyrophosphate, sodium
hexametaphosphate and sodium
tripolyphosphate
2, 5
2, 5, 9, 11
2, 5, 7
7558-80-7, 7758-169
Morley GW
231-449-2
7558-80-7
16th April 2012 - page 1-41
Hahn F, Seifen E
sodium phosphate monobasic, sodium
acid pyrophosphate, tetrasodium
pyrophosphate, sodium polyphosphate,
sodium metaphosphate, potassium
metaphosphate, calcium phosphate,
monobasic, calcium phosphate dibasic,
ferric pyrophosphate, sodium
2, 5, 7, 9, 10, 17,
monoflurophosphate
21, 22, 28, 47
7558-80-7
Ishidate M, Sofuni T.
1988
chromosomal aberration test in vitro
In vitro
sodium phosphate, monobasic, sodium
acid pyrophosphate, potassium
metaphosphate, sodium
metaphosphate (different CAS number
to that considered by IPC)
2, 5, n/a, 17
7558-80-7
Ishidate M. et al
1984
primary mutagenicity screening of food additives
currently used in Japan
bacteria salmonella (ames
test)
Fd. Chem. Toxic. 22(8): 623-636
sodium phosphate, monobasic, sodium
acid pyrophosphate, potassium
metaphosphate, sodium
metaphosphate (different CAS number
to that considered by IPC)
2, 5, n/a, 17
7558-80-7
Ishidate M. et al
1984
primary mutagenicity screening of food additives
currently used in Japan
hamster fibroblasts
Fd. Chem. Toxic. 22(8): 623-636
7558-80-8
Ishidate M.
1991
test on chemicals in bacteria
bacteria
data book of mutagenicity
7558-79-4, 7722-885, 7758-29-4
Feldheim W and Hesselbach C
1985
Untersuchungen zum calcium- und
phosphorstoffwechsel beim menschen.
Minature pig
Art Ernahr. 10. 30-33
sodium phosphate monobasic, sodium
acid pyrophosphate, tetrasodium
pyrophosphate, sodium polyphosphate,
potassium metaphosphate, ferric
pyrophosphate
2, 6, 7, 9, 17, 28
disodium hydrogenphosphate,
tetrasodiumpyrophosphate, sodium
tripolyphosphate, grahams salt
2, 7, 0, 11
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
monosodium phosphate, tetrasodium
pyrophosphate, sodium
hexametaphosphate, dipotassium
phosphate, monocalcium phosphate,
tricalcium phosphate
sodium orthophosphate, sodium
metaphosphate
monosodium phosphate, sodium
hexametaphosphate
monosodium phosphate, disodium
phosphate, sodium
tripolyphosphate, dicalcium
phosphate
monosodium phosphate, disodium
phosphate, trisodium phosphate
monosodium phosphate, disodium
phosphate, trisodium phosphate,
tetrasodium pyrophosphate
ammonium polyphosphate,
monoammonium phosphate,
diammonium phosphate
monocalcium phosphate (hydrate),
dipotassium phosphate
monocalcium phosphate,
dipotassium
hydrogenorthophosphate, sodium
dihydrogenorthophosphate
monohydrate
Sub ID
CAS Nr.
2, 7, 10, 12, 21,
24
7778-77-0
Authors
Study
Year
Verret J. et al
1980
16th April 2012 - page 1-42
Object [title of the article]
Organism tested
Source [journal name]
Toxicity and Teratogenicity of 80 food additives
chemicals in the developing chicken embryo
chicken embryo
Toxicology and applied pharmacology 56: 265-273
ABSTRACT: effects on long-continued ingestion of
sodium phosphate upon the parathyroid, kidneys
and bones of mature rats
Rats
hexametaphosphate, anticoagulant actin in vivo and
in vitro
dog
2, 9
7558-80-7
Saxton J.A. And Ellis G.H.
1941
2, 9
68915-31-1
Tria E.
1950
2,3,0,22
7558-80-7
Bushman DH, Emerick RJ & Embry
LB
1965
Incidence of urinary calculi in sheep as affected
by various dietary phosphates
sheep
J Anim Sci 1965. 24:671-675.
Anderson BG
1946
The toxicity thresholds of various sodium salts
determined by the use of Daphnia magna.
daphnia magna.
Sewage works Journal. 18(1): 82-87
1911
Ionenwirkkung der Phosphorsauren
?
Biochem Z. xxxii: 243-264
2,3,4
7558-80-7
2,3,4,7
Starkenstein E
SIDS intial assessment
profile.SIAM.24.
20, 18, 19,
68333-79-9
21, 12
7758-23-8
21, 12, 2
7758-23-8
2007
Da silva L.R.C. Et al
1991
Krook L, Lutwak L, Hnrikson P,
Kallfelz F, Hirsch C, Romanus B,
Belanger LF, Marier JR and Shefft
BE
1971
am j path 17: 590
boll soc ital biol sper 26 (chem abstr 45-8643): 113
SIDS intial assessment profile.SIAM.24.
US ICCA SIAM phosphates 4-2007.pdf
rats, fish
effects of phosphate sources on the mycelial growth
of gigaspora gigantea in vitro
fungus
Revista Brasileira de Ciencia do solo 156: 169-172
Reversibility of Nutritional Osteoporosis:
Physicochemical Data on Bones from an
Experimental Study in Dogs
dogs
The journal of nutrition. 101:233-246
JECFA
N/A
Published in 1967, 1992 and 1996. Revised at the 26th
JECFA 1982.
46th JECFA.
monocalcium phosphate, diammonium
phosphate, sodium metaphosphate
insoluble, sodium hexametaphosphate,
sodium polyphosphate
21, 19, 11, 10, 9,
dibasic calcium phosphate dihydrate,
mono-dicalcium phosphates, dimonocalcium phosphates.
monocalcium phosphate, dicalcium
phosphate
monocalcium hposphate, dicalcium
phosphate
7758-23-8
1996
21, 22
7758-23-8
Sullivan TW
1992
21, 22
7758-23-8
Sullivan TW et al
1989
21, 22
7758-23-8
Waibel PE et al
1984
Correlation of biological value of feed phosphates
with their solubility in water, dilute hydrogen chloride,
dilute citric acid and neutral ammonium citrate.
turkey
Evaluation of new and established feed phosphates
in turkey starter diets
turkey
bioavailability of phosphorous in commercial
phosphate supplements for turkeys.
turkey
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Poultry Science. 71:2065-2075
Poultry Science. 68(1):143
Poultry Science. 63:730-737
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
monocalcium phosphate, dicalcium
phosphate
21, 22
monocalcium phosphate, dicalcium
phosphate
monocalcium phosphate, dicalcium
phosphate
CAS Nr.
Object [title of the article]
16th April 2012 - page 1-43
Organism tested
Nitrogen and Phosphorus Partitioning in
Lactating Holstein Cows Fed Different Sources
of Dietary Protein and Phosphorus
cows
Source [journal name]
7558-23-8
Knowlton KF, Herbin JH, MeisterWeisbarth MA and Wark WA
2001
21, 22
7758-23-8
Hepher B & Sandbank S
1984
21, 22
7758-23-8
Keshavarez K
1994
The effects of phosphorus supplementation to
common carp diets on fish growth.
fish
Laying hens respond differently to high dietary
levels of phosphorus in monobasic and dibasic
calcium phosphate.
hens
21, 22, 18
7758-23-8
Lima FR et al
1999
Laboratory evaluations of feed-grade and agriculturalgrade phosphates
N/A
Poult. Sci. 78(12):1717-1728
American Institute of Nutrition. 553-567
J. Dairy Sci. 84:1210–1217
Aquaculture, 36:323-332
Poultry Science. 73: 687-703
Calcium
bis(dihydrogenorthophosphate),
Calcium hydrogenorthophosphate,
ammonium dihydrogenorthophosphate,
Thermomagnesium phosphate
calcium phosphate monobasic, calcium
phosphate dibasic, sodium phosphate
monobasic.
21, 22, 2
7758-23-8
Richardson NL et al
1985
Influence of dietary calcium, phosphorous, zinc and
sodium phytate level on cateract incidence, growth
and histopathology in juvenile Chinook salmon
(Oncorhynchus tshawytscha).
21, 22, 23, 24
7758-23-8
Gillis MB et al
1952
Studies on the availability of calcium orthophosphate
to chickens and turkeys
chicken
21, 22, 23, 24
7758-23-8
Wise DL, Trantolo DJ, Altobelli DE,
Yaszemski MJ, Gresser JD and
Schwartz
21, 22, 24
7558-23-8
Cameron FK and Siedell A
fish
Monocalcium phosphate, Dicalcium
phosphate, Beta-tricalcium phosphate,
Tricalcium phosphate
MCP, DCP, HAP, Calcium sodium
phosphate, β-TCP,
Dicalcium phosphate, tricalcium
phosphate, monocalcium phosphate
Moncalcium phosphate hydrate, dibasic
calcium phosphate, basic tricalcium
phosphate
monocalcium phosphate, dicalcium
phosphate, tricalcium phosphate,
monocalcium phosphate, dicalcium
phosphate, tricalcium
phosphate/hydroxyapatite, octocalcium
phosphate
monocalcium phosphate, dicalcium
phosphate, tricalcium
phosphate/hydroxyapatite, octocalcium
phosphate
monocalcium phosphate, dicalcium
phosphate, defluorinated phosphate
21, 22, 24
7758-23-8
Carstensen JT
J. Nutr. 78(2): 155-161
Encyclopaedic handbook of biomaterials and
bioengineering. Part B: Applications. Vol 1
1910
The action of water upon the phosphates of calcium. N/A
J Am Chem Soc 26: 1454-1463
1988
Handling of non-sink conditions: In vitro dissolution
rates of some common pharmaceutical calcium
salts
N/A
Drug development and industrial pharmacy, 14(4): 19711989
sewage sludge
European Journal of Soil Science. 45: 403-408
21, 22, 24
7758-23-8
Frossard E, Tekely P and Grimal JY
1994
Characterisation of phosphate species in urban
sewage sludges by high-resolution solid-state 31P
NMR.
21, 22, 24, n/a
7758-23-8
Lehr J.R. And Brown W.E.
1958
calcium phosphate fertilizers: II a petrographic study
of their alteration in soils
soil
21, 22, 24, n/a
7758-23-8
Terman G.L. Et al
1958
21, 22, n/a
7758-23-8
Sullivan TW and Douglas JH
1987
calcium phosphate fertilizers: I availability to plants
and solubility in soils varying in pH
Bioavailability of bone precipitated dicalcium
phosphate in turkey starter diets.
soil sci soc amer proc 22: 29-32
ryegrass
soil sci soc amer proc 22: 25-29
turkey
Poultry Sci(1): 182
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
monocalcium phosphate, dicalcium
phosphate, defluorinated phosphate,
tricalcium phosphate
monocalcium phosphate, tricalcium
phosphate
monocalcium phosphate, calcium
pyrophosphate, monosodium
phsohate, sodium acid
pyrophosphate, calcium
metaphosphate, sodium
metaphosphate
Sub ID
CAS Nr.
21, 22, n/a, 24
7758-23-8
Authors
Study
Year
Sullivan TW
Object [title of the article]
Organism tested
Source [journal name]
1966
A triple response method fpr determining biological
value of phosphorus sources with young turkeys
turkey
Poultry Science. 45:1236-1245
Ignatowicz S.
1980
effects of inorganic salts upon biology and
development of acarid mites> IV. Effects of calcium
phosphate surplus in food upon fecondity, life spam
and development of copra mite Tyrophagus
putrescentia
acarid mites
polish J entomo 50: 289-298
Peeler HT
1972
Biological avaiilability of nutrients in feeds:
availability of major mineral ions.
sheep
J Anim Sci 1972. 35:695-712.
Greenwald I et al
1940
The dissociation of Calcium and Magnesium
Phosphates.
N/A
J Biol Chem, 135: 65-67
R. A. ARGENZIO, J. E. LOWE, H.
F. HINTZ, AND H. F. SCHRYVER
1974
Calcium and Phosphorus Homeostasis in
Horses
horse
J Nutr. 104. 18-27
21, 24
7758-23-8
21, 26, 2, 5,
7758-23-8
21, 29
7758-23-8
22, 2
7757-93-9
22, 21, 18
7757-93-9
Fernandes JIM et al
1999
Relative bioavailability of phosphorus in feed and
agricultural phosphates for poultry.
poultry
Poult. Sci. 78:1729-1736.
22, 26
7789-77-7
Buttner W. and Muhler J.C.
1958
The effect of feeding calcium phosphate salts with
different solubilities on dental caries, the
composition of the saliva and the femur of rats
Rats
J. D. Res. 37(5): 860-864
1970
Soluble complexes in the systems dicalcium
phosphate dihydrate or dimagnesium phosphate
trihydrate equilibrated with aqueous salt solutions
N/A
Can. J. Soil. Sci. 50:243-253
1972
Comparative effects of oral administration of
urea and urea phosphate on the concentrations
of ammonia and urea in the blood of sheep
Sheep
Br. Vet. J:. 128:
1960
stability of dicalcium phosphate dihydrate in
aqueous solutions and solubility of octocalcium
phosphate
soils
soil. Science soc. Proc: 99-102
1961
The availability of phosphorus from single and
combined phosphates to chicks
chicken
Poultry Sci 40:1321-1328
1993
The effects of calcium phosphate ceramic
composition and structure on in vitro behaviour. I.
Dissolution
n/a
Journal of Biomedical materials research. 27: 25-34
monocalcium phosphate, Magnesium
phosphate
dicalcium phosphate, monosodium
phosphate
Calcium hydrogen orthophosphate,
Calcium
bis(dihydrogenorthophosphate),
Ammonium dihydrogenorthophosphate
dicalcium phosphate dihydrate,
dicalcium pyrophosphate
Calcium hydrogenorthophosphate,
Dimagnesium phosphate
22, 29
dicalcium phosphate and urea
phosphate
22, 51
dicalcium phosphate dihydrate,
octacalcium phosphate
22, n/a
beta-tricalcium phosphate, dicalcium
phosphate
23, 22
hydroxyapatite, beta-tricalcium
phosphate
16th April 2012 - page 1-44
23, 24
7757-93-9
231-826-1
7789-77-7
Webber MD
Hemingway RG, Parkins JJ and
Ritchie NS
Moreno E.C. Et al
7758-87-4, 7757-939
Nelson TS and Peeler HT
7758-87-4, 1216774-7
Ducheyne P, Radin S & King L
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
Object [title of the article]
16th April 2012 - page 1-45
Organism tested
Source [journal name]
beta-tricalcium phosphate
Tricalcium phosphate
hydroxyapatite, beta-tricalcium
phosphate
beta-tricalcium phosphate, deflurinated
phosphate, dicalcium phosphate,
monocalcium phosphate
23, 24
7758-87-4, 1306-06- Eisenberger S, Lehrman A and Turner
5
WD
23, 24
23, n/a, 22, 21
1938
The basic calcium phosphates and related systems.
Some theoretical and practical aspects
N/A
Chem Rev. 26:257-96
7758-87-4, 12167- Slosarczyk A, Paluszkiewicz C,
74-7
Gawlicki M & Paszkiewicz Z
1977
The FITR Spectroscopy ans OXDR studies of
calcium phosphate based materials produced from
the powder precursors with different Ca/P ratios
Ceramics international. 23. 297-304
7758-87-4, n/a,
7757-93-9, 7758-238
Nelson TS and Walker AC
1964
The biological evaluation of phosphorus compounds.
A summary.
chicken
n/a
Poultry Sci 43:94-98
Tricalcium phosphate, Dicalcium
phosphate, Monocalcium phosphate,
Phosphoric acid
tricalcium phosphate, monocalcium
phosphate
24, 22, 21, 48
12167-74-7
Cameron FK and Seidell A
1905
24, 21
12167-74-4
Majumder S.K., Bano A.
1964
tricalcium phosphate, monocalcium
phosphate, dicalcium phosphate,
monosodium phosphate, disodium
phosphate, monopotassium
phosphate, dipotassium phosphate, 24, 21, 22, 2,
phosphoric acid
3, 12, 13, 48
12167-74-7
Satoh SH, Porn-Ngam N, Takeuchi
T and Watanbe T
1993
Hydroxyapatite, Tricalcium phosphate,
Monocalcium phosphate monohydrate,
Β-tricalcium phosphate, Dicalcium
phosphate dihydrate, Vitreous calcium
metaphosphate, Fluorapatite,
Potassium calcium pyrophosphate
TCP, DCP/DCPA and DCP dihydrate
The Phosphates of Calcium I.
Toxicity of calcium phosphate to some pests of
stored grain
N/A
J AM Chem Soc 27(12): 1503-1512
insects
Nature 202: 1359-1360
Effect of Various Types of Phosphates on Zinc
Availability to Rainbow Trout
fish
Nippon Suisan Gakkaishi. 59(8): 1395-1400
N/A
Agricultural and Food Chemistry. 5(4): 266-275
24, 21, 23, 22
12167-74-7
Huffman EO et al
1957
24, 22
12167-74-4
Nancollas GH
1979
Rates of Solution of Calcium Phosphate in
Phosphoric Acid Solutions
Calcium phosphates – speciation, solubility and
kinetic considerations.
2001
Determination of calcium/phosphorus atomic ratio of
calcium phosphate apatites using x-ray
diffractometry
N/A
J. Am Ceram. Soc. 84(2): 359-366
1982
X-ray Diffraction of calcined bone tissue: a reliable
method for the determination of bone Ca/P molar.
Calcified Tissue International. 34:S93-S98
hydroxyapatite, beta-tricalcium
phosphate,
24, 23
1306-06-5
Raynaud S, Champion E, BernacheAssolant and Laval JP
hydroxyapatite, beta-tricalcium
phosphate
24, 23
12167-74-4
Balmain N, Legros R and Bonel G
ACS Symposium 93: 475-497
n/a
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Sub ID
CAS Nr.
tricalcium phosphate, beta-tricalcium
phosphate
24, 23
12167-74-4
Flatley TJ, Lynch KL and Benson M
DICALCIUM PYROPHOSPHATE,
SODIUM METAPHOSPHATE
INSOLUBLE
26, 11
7790-76-3
Huffman E.O and Fleming J.D.
26, 21, 22,
7790-76-3
dicalcium pyrophosphate, monocalcium
phosphate, tetracalcium phopshate.
calcium pyrophosphate, ammonium
pyrophosphate, calcium ammonium
pyrophosphate
iron phosphate, aluminium phosphate,
tricalcium phosphate,
Chow L.C., Takagi S., Shern R.J.,
Chow T.H., Takagi K.K and Sieck B.A
16th April 2012 - page 1-46
Object [title of the article]
Organism tested
Source [journal name]
1983
Tissue response to implants of calcium phosphate
ceramic in the rabbit spine
Rabbit
Clinical orthop Rel Res. 179: 256-252
1960
rate and mechanism of its hydrolytic degradation
1994
Effect on whole saliva of chewing gums containing
calcium phosphates.
. J. Phys. Chem. 64:240-244
human
Journal of dental research.73,26-32.
http://jdr.sagepub.com/cgi/reprint/73/1/26.pdf
26, n/a, n/a
7790-76-3
Hossner L.R. And Melton J.R.
1970
27, 40, 24
10045-86-0
Cameron FK and Hurst LA
1904
Polyphosphate Hydrolysis of Ammonium, calcium
and calcium ammonium pyrophosphates in selected
Texas soils
soil
The action of water and saline solutions upon certain
slightly soluble phosphates.
N/A
29, 27
7757-86-0
Cameron FK and Bell JM
1907
The Phosphates of Magnesium and Iron
N/A
J Phys Chem 11(5): 363-368
29, 30, 31, 60
7757-86-0
Frazier AW and Waerstad KJ
1992
The phase system MgO-(NH4)2O-P2O5-H2O at
25°C.
N/A
Ind Eng Chem Res, 31: 2065-2068
1942
?
N/A
Izv Akad Nauk SSSR. ?:268-273
1966
The effect of oral sodium phosphate on the
formation of renal calculi and on idiopathic
hypercalcuria.
1959
Further observations on the cariostatic effects of
phosphates
1960
the cariostatic effect in white rats of phosphorus and
calcium supplements added to the flour of bread
formulas and to bread diets
Rats
bacteria
mice
soil sci soc amer proc 34: 802-805
The Journal of The American Chemical Society. 26(8): 885913.
Dimagnesium phosphate, Ferric
phosphate
MgHPO4.3H2O (newberite)
Mg3(NH4)2(HPO4)4.8H2O
Mg3(NH4)2(HPO4)2.4H2O –A
(Schertelite)
Mg3(NH4)2(HPO4)2.4H2O –B
MgNH4PO4.6H2O (struvite)
disodium hydrogenorthophosphate,
dipotassium hydrogenorthophosphate
3, 13
7558-79-4, 7758-114
Ravich MI and Popova ZV
Bernstein D.S, Newton R.
disodioum phosphate, monosodium
phosphate
disodium phosphate, calcium
phosphate monobasic, calcium
phosphate dibasic
Na2HPO4, calcium phosphate
monobasic, calcium phosphate dibasic
sodium phosphate (Na2HPO4),
trisodium phosphate, sodium acid
pyrophosphate, trisodium
trimetaphosphate (3-hydrate), sodium
metaphosphate, sodium
hexametaphosphate, monopotassium
phosphate, potassium pyrophosphate,
potassium polyphosphate (add. Non-ip
substances)
disodium phosphate dodecahydrate,
phosphoric acid,
disodium phosphate, sodium acid
pyrophosphate, tetrasodium
pyrophosphate, sodium
metaphosphate, sodium
tetrametaphosphate
3, 2,
7558-79-4
3, 21, 22
7558-79-4
3, 21, 22
7558-79-4
McClure F.J and Muller A.
McClure F.J.
The Lancet. Nov. 19:1105-1107
Rats
3, 4, 5, 8, 9, 10,
12, 15, 17
7558-79-4
Shibata H
1981
Antibacterial action against streptococuss mutans
and inhibitory effect on the experimental Hamster
caries of condense phosphates
3, 48
7558-79-4
Nofre C., Dufour H. and Cier A.
1963
compared toxicity of 32 mineral anions in the mice
3, 5, 7, 9, n/a
7558-79-4
Jen C.M.C, Shelef L.A.
1986
factors affecting sensitivity of Staphylococcus aureus
196E to polyphosphates
bacteria
Publicly available published studies of which the IP Consortium has purchased a copyright copy
J. D. Res. 38(4): 776-781
J. Nutrition 72: 131-136
Fukuoka Igaku Zasshi 6:379-391
comptes rendus des sceances de l'academie des sciences
257: 791-794
applied and environmental microbiology: 842-846
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
disodium hydrogenphosphate,
tetrasodiumpyrophosphate,
monopotassium phosphate
disodium phosphate, tetrasodium
pyrophosphate, trisodium
trimetaphosphate, diammonium
phosphate, calcium phosphate dibasic
Study
Year
Authors
3, 7, 12
3, 7, 8, 19, 22
CAS Nr.
7558-80-7, 7722-885, 7778-77-0
Menzel VH and Gabler C
7558-79-4
Van Reen R. and Ostrom C.A.
16th April 2012 - page 1-47
Object [title of the article]
Organism tested
Source [journal name]
1929
Uber verbindungen von alkaliphosphaten mit
wasserstoffperoxyd
N/A
Z Anorg Chem. 177:187-198
1962
Effects of dietary phosphate supplements on dental
caries in the rat
Rats
J. D. Res 41: 875-882
Amoeba and rotifer and
Amphibian (Bufo bufo and institut fur Landwirtschaftliche Zoologie und bienenkunde,
Xenopus laevis)
Report 33 pages
disodium phosphate (DSP), tetrasodium
polyphosphate, grahams salt,
potassium dihydrogen orthophosphate,
calcium phosphate monobasic, calcium 3, n/a, 9, 12, 21,
phosphate tribasic, iron pyrophosphate
24, 28
7558-79-4
Wuembach et al
1966
Research into the toxicity and effects of
polyphosphates on growth of cultures of amoeba,
rotifers, tadpoles, and on the succession of
organisms in cellulose decomposition
disodium phosphate, sodium acid
pyrophosphate, sodium
hexametaphosphate, phosphoric acid
7558-79-4
Konig K.G. Et al
1961
effects of some phosphates in a short-period rat
caries experiment
Rats
2004
Magnesium hydrogen phosphate prepared at the
26th JECFA (1982) published in 1982 and 1992.
Revised at the 63rd JECFA (2004).
n/a
trimagnesium phosphate, potassium
tripolyphosphate
trimagnesium phosphate, trisodium
phosphate
trisodium phosphate, monosodium
phosphate
trisodium phosphate, monosodium
phosphate
3,5, 10, 48
30, 16
30, 4
7757-87-1
7757-87-1
63rd JECFA
57th JECFA
2001
7601-54-9
1939
Boll Soc Ital Biol Sper, 14():136-137
?
4: 1382 - 1383
N/A
Ztschr. Elektrochem. 43 (2): 104-
1981
Simon I.
4, 2
7601-54-9
n/a
Trimagnesium phosphate prepared at the 17th JECFA
(1973) published in 1978 and 1992. Revised at the 57th
JECFA (2001).
JEFCA
N/A
The topically irritant substance: Essentials-bio-testpredictions.
Minimal Lethal Dose of some Sodium Salts Injected
Intravenously.
Bucher k., Bucher K.E., Walz D.
4, 2
Arch. Oral biol. 3: 258-270
Abderhalden E.
trisodium phosphate, disodium
phosphate
4, 3
7601-54-9, 7758-794
1935
Handbuch der biologischen Arbeitsmethoden:
Chemische und physikalische
Untersuchungsmethoden der Pharmakologie und
Toxikologie.
trisodium phosphate, disodium
hydrogenorthophosphate
4, 3
7601-54-9, 7758-794
Menzel
1937
Studien an alkaliphosphaten und arsenaten II):
Tertiares natriumphosphat
Agents and actions, 11(5): 515-519
trisodium phosphate anhydrous, sodium
acid pyrophosphate, tetrasodium
pyrophosphate, tripotassium phosphate,
monocalcium phosphate
4, 5, 7, 14, 21
7601-54-9
Weiner M. et al
1987
ABSTRACT: Dermal toxicity/ skin irritation studies on
five inorganic phosphates
Rabbits
?
trisodium phosphate anhydrous, sodium
acid pyrophosphate, tetrasodium
pyrophosphate, tripotassium phosphate,
monocalcium phosphate
4, 5, 7, 14, 22
7601-54-9
Weiner M. et al
1986
ABSTRACT: Eye irritation studies on five inorganic
phosphates
?
Rabbits
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
trisodium phosphate, sodium acid
pyrophosphate, trisodium
trimetaphosphate, sodium
hexametaphosphate
trisodium phosphate, tetrasodium
pyrophosphate, sodium
hexametaphosphates
trisodium phosphate, monosodium
phosphate
trisodium phosphate, tetrasodium
pyrophosphate, sodium metaphosphate
insoluble, tetrapotassium
pyrophosphate, sodium
tripolyphosphate
Aluminium orthophosphate,
hydroxyapatite
aluminium phosphate, iron phosphate
aluminium phosphate, magnesium
hydrogen phosphate
Sub ID
CAS Nr.
4, 5, 8, 10
7758-16-9
Authors
Study
Year
Behrens B. and Seelkopf K.
Object [title of the article]
Organism tested
Source [journal name]
1933
Pharmacology of the meta phosphoric acids
mice
arch exp path pharmak 169():238
1947
Estimation of triphosphoric and pyrophosphoric
acids: In the presence of ortho- and metaphosphoric
acids.
n/a
Anal. Chem. 19:97-100
1915
Observations on the effect of intravenous
injections of sodium phosphate
Journal of Pharmacology and Experimental Therapy.
7: 57-61
Bell R.N.
4, 7 , 10
7758-16-9
4,2
Greenwald I
16th April 2012 - page 1-48
rabbit, dog
Irani R.R. and Callis C.F.
4,7, 11, 15, 0
7601-54-9
1962
40, 24
7784-30-7
Hanawa T, Kaga M, Itoh Y, Echizenya
T, Oguchi H and Ota M
1992
40, 27
7784-30-7
Marks J et al
1956
40, 29
7784-30-7
Boudraa M’hamed et al
40. 24, 22, 27
7784-30-7
46, 8
47
Calcium and magnesium sequestration by sodium
and potassium polyphosphates.
n/a
Cytotoxicities of oxides, phosphates and sulphides of
metals.
N/A
Journal of the American Oil Chemists' Society. March: 156159
Biomaterials. 13(1): 20 – 24
1991
A study of dust toxicity using a quantitative tissue
culture technique.
Etudes physico-chemiques de AlPO4, de
MgHPO4.3H2O et leurs melanges.
N/A
British Journal of Industrial Medicine. 13: 187-191
Acta Poloniae Pharmaceutica- Drug Research. 48(3-4): 6368
Lindsay WL and Moreno EC
1960
Phosphate phase equilibria in soils
N/A
Soil sci soc Am J. 24(3):177- 182
24315-83-1
Thilo E. and Wieker W.
1959
the hydrolyse of condensated phosphates in
aqueous solution
water
Naturwissen, 46:367-373
10163-15-2
Ripa LW & Leske GS
1985
Clinical Trial of a Combined MFP-NaF Dentifrice
Formulated at Different Concentrations
Human
NTIS
1986
Contact Dermatitis From Foods and Food Additives.
582-594 and 851,855 and 904
Contact Dermatitis Third edition Lea & Febiger Philadelphia
1986
N/A
Aluminium orthophosphate dihydrate,
hydroxyapatite, dicalcium phosphate
dihydrate, Iron orthophosphate dihydrate
sodium potassium polyphosphate,
trisodium trimetaphosphate
sodioum monoflurophosphate
disodium fluorophosphate,
monoammonium phosphate,
monosodium phosphate
Fisher AA
47, 18, 2
10163-15-2
48, 11
7664-36-2
Eberly NE et al
1920
The system zinc oxide, phosphorous pentoxide and
water at 25° and 37°
48, 12, 14, 18,
19
7664-38-2
Parker EG
1914
The ternary systems, Potassium – Phosphoric acid –
Water and Ammonia – Phosphoric acid – Water
N/A
J Phys Chem, 18: 653-661
48, 18
7664-38-2
Kubasova L V
1971
Polyphosphoric acids and their ammonium salts.
Russian Chemical Reviews, 40 (1) 1 - 12.
Phosphoric acid, Graham’s salt
Phosphoric acid, Potassium
dihydrogenorthophosphate,
Tripotassium orthophosphate,
Ammonium dihydrogenorthophosphate,
Diammonium hydrogenorthophosphate,
Triammonium phosphate
phosphoric acid, monoammonium
phosphate
N/A
Publicly available published studies of which the IP Consortium has purchased a copyright copy
J Am Chem Soc, 42(7): 1433-1439
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
16th April 2012 - page 1-49
Object [title of the article]
Organism tested
Source [journal name]
N/A
Fluid Journal
rabbit
Toxicology of the eye, Second Edition. Charles C Thomas
USA
phosphoric acid, diammonium
phosphate, sodium acid pyrophosphate,
sodium tripolyphosphate
48, 19, 5, 0
7664-38-2
Lohry R
2001
Ortho Vs. Poly. Author takes a look at the history
and behaviour of ortho and polyphosphates. Fluid
Journal
phosphoric acid, monocalcium
phosphate, sodium hexametaphosphate
48, 21, 10
7664-38-2
Grant W M, .
1974
Toxicology of the Eye (Handbook)
48, 27
7664-36-2
Carter SR and Hartshorne NH
1926
The system ferrous oxide-phosphoric acid-water and
some of its oxidation products
N/A
48, 4
7664-38-2
1988
48, 50
7664-38-2
Young JR et al
Beranger-Yvon. A., Champighy M.L.,
Guyon D.
Phosphoric acid, iron phosphate
phosphoric acid, trisodium
orthophosphate
orthophosphoric acid, pyrophosphoric
acid
1958
classification without testing
Measure of photosynthesis and of growth, Chlorella
alga (8 days culture)
N/A
algae (chlorella
pyrenoidosa)
?
Toxic in vitro, vol 2, no 1, pp 19-26, 1988
revue de cytologie et de biologie vegetale (19): 433-452
Bloch-Frankenthal L.
Sodium pyrophosphate
5 (OR 7)
7758-16-9
sodium pyrophosphate
Sodium pyrophosphate
sodium acid pyrophosphate / sodium
pyrophosphate
Sodium pyrophosphate (SAPP or
TSPP)
5 (OR 7)
5 (OR 7)
7758-16-9
7758-16-9
Natarajan A.T. And Ahnsrom G.
Salzer
1968
1894
5 / 7,
7758-16-9
Daugherty F.M.
1951
The role of magnesium in the hydrolysis of sodium
pyrophosphate by inorganic pyrophosphatase.
rat (blood)
cytogenetic effects of inorganic pyrophosphate and 5fluoro deoxyuridine
plant (vicia faba)
?
N/A
Effect of some chemicals used in oil well drilling on diverse marine
marine animals
invertebrates
5 or 7
7758-16-9
Bayer KJ
1869
1) Chemische Notizen
5,
7758-16-9
Dowden B
1961
Cumulative toxicities of some inorganic salts to
daphnia magna as determined by median tolerance
limits
Daphnia
Sodium pyrophosphate
sodium acid pyrophosphate, sodium
tripolyphosphate
5, 0
7758-16-9
1954
Molins RA, Kraft AA, Olson DG,
Walker HW & Hotchkiss DK
sodium acid pyrophosphate, potassium
dihydrogenphosphate, tetrapotassium
7758-16-9, 7778-77pyrophosphate, monocalcium
0, 7320-34-5, 77585, 12, 15, 21, 25, 23-8, 14866-19-4,
phosphate, calcium dihydrogen
pyrophosphate, calcium pyrophosphate
26
7790-76-3
Morin C
sodium acid phosphate, monosodium
phosphate
5, 2
7758-16-9
Boyd, E.M., Seymour K.G.W.
N/A
Biochem J. 57,1: 97-92
Hereditas 59 (2-3): 229
Arch Pharm 232: 365-375
sewage ind. Wastes 23: 1282-1287
J Prakt Chem, 106: 501
Proc La Acad Sci, 23: 77-85
Inhibition of Clostridium sporogenes PA 3679
and Natural Bacterial Flora of Cooked VacuumPackaged Bratwurst by Sodium Acid
Pyrophosphate and Sodium Tripolyphosphate
With or Without Added Sodium Nitrite
1986
bacteria
Journal of Food Science. 51(3): 726-731
1946
No 264. Etude des polyphosphates de sodium,
potassium et calcium. II. Etude des polyphosphates
de sodium
N/A
untoward and toxic reaction of a range of different
products
rats
1965
Toxicity of selected chemicals to certain animals
invertebrates (various
dependent on substance)
j wpcf.37.1308-1316
1941
The effect of the intravenous administration of
phosphate solutions in normal rabbits
rabbits
J. Lab. Clin. Med. 7:68-70
1964
Pyrophosphate as a source of phosphorus for plants. n/a
1961
Bull. Soc. Chim. France: 1719-1740
Experimental Medecine and Surgery (4):223-227
Dowden B F and Bennett H J.
sodium acid pyrophosphate,
monosodium pyrophosphate
sodium biphosphate and sodium
phosphate mixture
5, 2
7758-16-9
5, 2 (?)
7758-16-9
Greenfield I
Sutton C.D. and Larsen S.
sodium acid pyrophosphate, disodium
phosphate
5, 3
7758-16-9
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Soil Sci. 97(): 196-201
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
Object [title of the article]
16th April 2012 - page 1-50
Organism tested
Source [journal name]
Firstenberg-Eden R et al
sodium acid pyrophosphate, trisodium
phosphate, sodium tripolyphosphate
sodium acid pyrophosphate,
pyrophosphoric acid
sodium pyrophosphate, pyrophosphoric
acid
5, 4, 0
7758-16-9
5, 49
7758-16-9
5, 50
7758-16-9
disodium dihydrogenpyrophosphate,
trisodium hydrogen diphosphate
5, 6
7758-16-9
Potassium polyphosphate (Kurrol salt)
mixture 2/3 tetrasodium pyrophosphate
(TSPP) 1/3 disodium pyrophosphate
(SAPP)
5, 7
7758-16-9
disodium dihydrogenpyrophosphate,
tetrasodium pyrophosphate
sodium acid pyrophosphate,
tetrasodium pyrophosphate
sodium pyrophosphate, sodium
metaphosphate, sodium
hexametaphosphate
sodium acid pyrophosphate, sodium
tripolyphosphate, sodium
hexametaphosphate, sodium
polyphosphate, calcium
polyphosphate.
sodium pyrophosphate, sodium
metaphosphate, sodium
hexametaphosphate, tetrapotassium
pyrophosphate, potassium
metaphosphate, dicalcium phosphate
sodium acid pyrophosphate,
tetrasodium pyrophosphate, sodium
tripolyphosphate
Various
5, 7
7758-16-9
1981
Nociti F.H. Et al
McGilvery J.D. And Crowther J.P.
cementum: a phosphate-sensitive tissue
1954
the hydrolysis of the condensed phosphates. II a) the
role of the hydrogen ion in the hydrolysis of sodium
pyrophosphate. II b) the dissociation constants of
pyrophosphoric acid
soil
1988
Van Esch GJ, Vink HH, Wit SJ, Van
Genderen H
1957
7758-16-9
5, 9, 10,
7758-16-9
5, 9, 10, 15, 17,
22
7758-16-9
5,7,0
50, 48, 8, 11, 17,
22, 21
7758-16-9
Various
J. D. Res. 81(12): 817-821
canadian J chem. 32: 174-185
the physiological effect of phosphates
bacteria
JOURNAL OF FOOD SCIENCE. 53(1): 28- 30
Mouse
Arzneimittel-forsch 7():172-175
bacteria
JOURNAL OF FOOD SCIENCE. 53(1): 25-27
Effect of Acid and Alkaline Pyrophosphate
Blends on the Natural Flora of a Cooked Meat
System
1988
1957
Das Adenylsäuresystem: neure ergebnisse und
probleme. Arzneimittel-Forschung.
Omoto M. et al
1986
ABSTRACT: Effects of condensed phosphates as a
food additive on the liver, Kidneys, muscles, and
bones of the mouse
mice
toxicology lett suppl 31: P1-54
Seward RA, Lin CF & Melanchoris
N
1986
heat sensitisation of Salmonella by
polyphosphate
bacteria
Journal of food science. 51(2): 471-473
Fujita H. and Sasaki M.
1990
Mutagenicity test of food additives with salmonella
typhimurium TA97 and TA102
bacteria
ann. Rep. Tokyo Metr. Res. Lab. P.H. 41: 315-322
1994
Bactericidal and Bacteriolytic Effects of Selected
Food-Grade Phosphates, Using
Staphylococcus aureus as a Model System
Bacteria
1950
Phosphorous Properties of the Element and Some
of Its Compounds. By the Staff of the Division of
Chemical Engineering.
7758-16-9
5, 9, 10
rats (mutant)
Effect of Acid and Neutral Pyrophosphates on
the Natural Bacterial Flora of a Cooked Meat
System
Boettge K., Jaeger K.H. and Mittenzwei
H.
5, 7
Journal of Food Science 46: 579-582
2002
Marcy JA, Kraft AA, Hotchkiss DK,
Molins RA, Olson DG, Walker HW
and White PJ
Marcy JA, Kraft AA, Hotchkiss DK,
Molins RA, Olson DG, Walker HW
and White PJ
Inhibition of Moraxella-Acinetobacter Cells by
Sodium Phosphates and Sodium Chloride.
Lee RM, Bartami PA, Olson DG &
Wiliams FD
Farr TD
Drug Research. 7:24-59
Journal of Food Protection, Vol. 57, No. 4, Pages
276·283
Tennessee Valley Authority Chemical Engineering Report
No. 8
N/A
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Various
polyphosphoric acid, magnesium
hydrogenorthophosphate, sodium
metaphosphate
Sub ID
CAS Nr.
50, 49, 48, 47,
11, 10, 9
(all ortho-,pyro-,
tri- phosphates,
0, 5, 7, 8, 10, 11,
47, 48, 49, 50)
Various
51, 29, 9
8017-16-1
Authors
Study
Year
Object [title of the article]
Organism tested
Source [journal name]
Audrieth
1950
TEXTBOOK
n/a
Inorganic syntheses Volume III: 85-117
1961
The effects of polyphosphoric acid and inorganic
salts upon the respiration of Ehrlich Ascites Tumor
Cells
tumor cells
Nihon Univ J. Med. 3: 365-385
?
Memorie della Reale Academia delle scienze di
Torina 54(2a):459-529
rabbit
Archiv fur experimentelle Pathologie und
Pharmakologie ixxvii: 45-82
N/A
Ohta. M
sodium pyrophosphate
7 (or 5)
Sabbatani L
1904
various: sodium pyrophosphate
7 (or 5)
Starkenstein E
1914
Funzione Biologica del Calcio
Uber die pharmakologische wirkung
kalziumfallender sauren und der magnesium
salze
?
1928
The chemical news –Sodium pyrophosphates
Sodium pyrophosphates
sodium pyrophosphate, Sodium
tripolyphosphate
sodium pyrophosphate, STPP ,sodium
hexametaphosphate
Sodium pyrophosphate
Sodium triphosphate
Sodium tetraphosphate
sodium pyrophosphate, sodium
tripolyphosphate, sodium
hexamaetaphosphate
tetrasodium pyrophosphate, sodium
tripolyphosphate, sodium
polyphosphate
7 or 5
7(or 5), 0
7722-88-5
7722-88-5, 7758-29- Watanabe M, Matsuura M and Yamada
4
T
1981
The mechanism of hydrolysis of polyphosphates.
V.the effect of cations on the hydrolysis of pyro- and
triphosphates
N/A
Bulletin of the Chemical Society of Japan. 53(3): 738-741
N/A
Die Chemie. 55(47/48): 351-366
7(or 5), 0, 10
7722-88-5
Watzel VDR
1942
Uber die hydrolysegeschwindigkeit von
pyrophosphate, tripolyphosphat und
hexametaphosphat.
7, 0,
7722-88-5
Quimby OT
1954
Soluble crystalline polyphosphates – their
purification, analysis and properties.
N/A
The Journal of Physical Chemistry, 58(8): 603-618
7, 0, 10
7722-88-5
Zessin KG and Shelef LA
1988
Sensitivity of Pseudomonas strains to
polyphosphates in media system
microorganisms;
pseudomonas
Journal of Food Science. 53(2):669-670
1965
Zur Frage Der Resorption von polyphosphaten (On
the question of absorption of polyphosphates)
rat
1998
Rapid Method for Separating and Quantifying
Orthophosphate and Polyphosphates:Application to
Sewage Samples.
n/a
Water Research Vol. 32, No. 3, pp.711-716
?
Determination of tripolyphosphate and related
hydrolysis products in processed shrimp,
n/a
US FDA. pp 92-100.
Gardner J and Symes W
1911
The physiological action of some camphene
phosphonates of sodium
rat
Biochemical Journal. 5: 390
Smith R.S. Et al
1956
effects of synthetic detergents on water coagulation
water
j am wat wks ass 48: 55-69
Fingerhut M et al
7, 0, 9
7722-88-5
D. Jolley, W. Maher & P. Cullen
tetrasodium pyrophosphate, disodium
phosphate
16th April 2012 - page 1-51
7, 2
7722-88-5
Heitkemper DT, Kaine LA, Jackson
DS and Wolnik KA,
tetrasodium pyrophosphate, disodium
phosphate, sodium tripolyphosphate
7, 2, 0
7722-88-5
tetrasodium pyrophosphate,
disodium orthophosphate, calcium
sodium phosphate,
7, 3
7722-88-5
tetrasodium pyrophosphate, trisodium
phosphate
7, 4
7722-88-5
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
Object [title of the article]
Organism tested
Source [journal name]
1957
Zusammenfassende Übersichtsberichtsberichte:
Zure Verwendung der Polyphosphate bei
Lebensmitteln. Z. Lebensmittel-Unters. U. -Forsch.,
Rand 106
?
?
1993
Tetrasodium pyrophosphate prepared at the 41st
JECFA publisehd in 1993, superceding
specifications prepared at the 37th JECFA,
publisehd in 1992. Revised at the 55th JECFA
(2000).
n/a
JEFCA
Friedrich Kiermeier & Klement Möhler
tetrasodium pyrophosphate, trisodium
phosphate, disodium phosphate,
monosodium phosphate
7, 4, 3, 2
7722-88-5
41st JECFA
tetrasodium pyrophosphate, sodium
acid pyrophosphate
7, 5
7722-88-5
tetrasodium pyrophosphate, sodium
polyphosphate
7, 9
7722-88-5
Tetrasodium pyrophosphate, sodium
acid pyrophosphate, trisodium
pyrophosphate, dicalcium
pyrophosphate
sodium trimetaphosphate, sodium
tetrametaphosphate, sodium
tripolyphosphate
7,5,6,26
8, 0
Lebron CI, Molins RA, Walker HW,
Kraft AA, Stahr HM
1989
7722-88-5, 7758-169, 14691-80-6,
7790-76-3
Corbridge DEC
7785-84-4, 7758-294
Watanable M, Sato S and Saito H
Inhibi'tion of Growth and Aflatoxin Production of
Aspergilli in Medium Containing Phosphates
yeat
Journal of Food Protection, Vol. 52(1): 4-6
1957
Crystallographic data on some hypophosphates and
pyrophosphates
N/A
Acta Cryst. 10: 85
1975
The mechanism of the hydrolysis of condensed
phosphates. III. The mechanism of the hydrolysis of
trimeta- and tetrametaphosphates
Bulletin of the Chemical Society of Japan 48(12): 35933597
1958
A paper chromatogragphic study of the effect of
synthetic digestive fluids on the sodium salts of Tri-,
Tetra-, and Hexametaphosphoric acids.
n/a?
Mitchell L C
sodium trimetaphosphate, sodium
hexametaphosphate
8, 10
7785-84-4
Lanigan
sodium trimetaphosphate, sodium
hexametaphosphate
trisodium trimetaphosphate,
monocalcium phosphate
8, 10
7785-84-4
8, 21
7785-84-4
N/A
Journal of the A. O. A. C, 41, 185-188.
1974
Final report on the safety assessment of sodium
metaphosphate, sodium trimetaphosphate and
sodium hexametaphosphate.
ABSTRACT: Effect of CaHPO4 and TMP on
carcigonicity in Human
bovine enamel
J. D. Res. 53: 606
2002
Determination of polyphosphates using ion
chromatography with suppressed conductivity
detection.
n/a
Dionex analysis condensed phosphates 2002.pdf
1969
sodium trimetaphosphate influence on the early
development of rat caries and concurrent microbial
changes
Rats
Caries Res. 3: 326-338
1970
Ion-exchange chromatographic analysis on the chain
length of polyphosphate products
N/A
Bulletin of the Chemical Society of Japan. 43: 2850-2858
2001
Koulourides T.
16th April 2012 - page 1-52
International Journal of Toxicology.
Dionex.
sodium trimetaphosphate, tetrasodium
pyrophosphate, disodium phosphate,
sodium tripolyphosphate
sodium trimetaphosphate
sodium polyphosphate, sodium
tripolyphosphate, tetrasodium
pyrophosphate
sodium metaphosphate, sodium
hexametaphosphate, potassium
metaphosphate, calcium phosphate
dibasic
sodium hexametaphosphate, potassium
metaphosphate
8, 7, 3, 0
8,
[35]
9, 0, 7
7785-84-4
7785-84-4
Henry C. and Navia J.
68915-31-1, 775829-4, 7722-88-5 Matsuura N, Lin T and Kobayashi Y
9, 10, 17, 22
68915-31-1
McClure F.J.
1963
Further studies on the cariostatic effect of organic
and inorganic phosphates
Rats
J. D. Res. 42(2): 693-699
9, 17
68915-31-1
Lang K. et al
1955
the metabolism of polyphosphates
rats
Biochemische Zeit. 327: 118-125
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
sodium metaphosphate, dicalcium
phosphate
sodium metaphosphate, sodium
trimetaphosphate
Study
Year
Authors
9, 22
CAS Nr.
10124-56-8
Lock S.O. Et al
Fluorine from rock phosphate
9, 8
N/A
10124-56-8
N/A
Various
N/A
N/A
Molins RA
Wang T and Li SFY
Zumpt I
phosphorus
N/A
N/A
Integrated risk information system.
ReferenceDoseForChronicOralExposur
e
Sodium potassium phosphate
N/A
N/A
Nanmann E
Iron (III) pentandenionate
Iron (III) diazaalkanolate
N/A
N/A
Fire Retardants and Firefighting Foams
Calcium metaphosphate CMP
N/A
N/A
N/A
77489-25-9
No IP substances studied
N/A
N/A
No IP substances investigated
ultraphosphates
N/A
N/A
N/A
N/A
Toxic. In vitro 1(2): 77-83
1998
1975
Separation of synthetic inorganic polymers of
condensed phosphates by capillary gel
electrophoresis with indirect photometric detection.
Chronic flouride poisoning in sheep
n/a
Sheep
Journal of Chromatography A, 802:159-165
J S Afr Vet Ass, 46: 161-163
Phosphates in Food (handbook)
Various
N/A
Http://www.epa.gov/iris/subst/0697.htm
Uber die Beeinflussung von Daphnia magna durch
einige Salze und Salzmischungen
Daphnia
Kungl Fysiografiska Sallskapets I Lung Forhandlingar Bd 4,
Nr 2
1933
Bullock JI et al
1992
Adams R and Simmons D
Allmaras R.R.
1999
1965
Contact uptake of metal compounds and their
molluscicidal effects on the slug, Deroceras
reticulatum (Muller) (Pulmonata: Limacidae)
Ecological effects of fire fighting foams and
retardants.
Hydrolysis of condensed phosphates in soils
1944
the toxicity thresholds of various substances found in
industrial wastes as determined by the use of
daphnia magna
daphnia magna.
Sew Works J. 16(6):1156-1165
1985
1992
Mutagenicity of metal ions in bacteria
Crystal Chemistry of Ultraphosphates
Environmental Research. 36: 379-388
Zeeitschrift fur Kristallographic 201: 69-92
Anderson BG
Arlauskas A, Baker RSU, Bonin AM,
Tandon RK, Crisp PT and Ellis J
Averbuch-Pouchot and Durif A
N/A
Bassett H and Bedwell WL
1933
No IP substances evaluated
N/A
N/A
Bautista EM and Alexander M
1972
Sodium and potassium polyphosphate
N/A
N/A
1957
No IP substances investigated
N/A
N/A
Bennet et al
Biesinger KE, Lemke AE, Smith WE
and Tyo RM
1976
Calcium metaphosphate CMP
N/A
N/A
Bird HR, Caskey CD
1943
Unknown
N/A
N/A
Blahm TH
1979
Phos-Chek XA, Fire-Trol 931
N/A
N/A
Blahm TH and Snyder GR
N/A
Source [journal name]
1987
N/A
N/A
Organism tested
extracellular release of enzymes from macrophages
in vitro for measuring cellular interaction with
particulate and non-particulate materials
mammalian cells
Ammonium magnesium phosphate
along with a number of other
phosphates
Unknown
Object [title of the article]
16th April 2012 - page 1-53
Boyer J
Studies of Phosphates. Part II. Orthophosphates of
the type M3(PO4)2,XH2O. 871-882
Part IV. Pyrophosphates of some bivalent metals
and their double salts, and solid solutions with
sodium pyrophosphates.
Reduction of inorganic compounds by soil
microorganisms.
Hydrolytic degradation of polyphosphates in liquid
detergent formulations
Comparative toxicity of polyelectrolytes to selected
aquatic animals.
Slug
N/A
soil
n/a
Crop protection, 11: 329-334
Conference Proceedings, Australian Bushfire Conference,
Albury July 1999
soil science soc proceedings 487-488
Bassett & Bedwell Studies of Phosphates I - IV 1412-1429
and 871-882
microorganisms
Soil Sci Soc Am J. 36(6)
N/A
Soap and Chem Spec 33: 44-47
fish
J Water Pollut Control Fed. 48(1):183-187
1973
Amorphous calcium metaphosphate as a
phosphorous supplement for chicks
white leghorn chickens
Toxicity of chemical fire retardants to juvenile coho
salmon and rainbow trout
Fish
Effect of Chemical Fire Retardants on the Survival of
Juvenile Salmonids.
N/A
Poultry Sci. 22:333-334
Diss Abstr Int B Sci Eng - phD thesis Univ Idaho, ID 40,
39(9): 4115
National Marine Fisheries Service Environmental Facility
Prescott, Oregon.
1980
Toxicite apparentte de certain engrais phosphates et
intoxication manganique induite. Journee Georges
Aubert.
?
?
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Fire-Trol GTS-R, Fire-Trol LCG-R, PhosChek WD-881 and Ansul Silv-Ex and
Phos-Check D75-R
Study
Year
Authors
N/A
CAS Nr.
N/A
Buhl KJ and Hamilton SJ
16th April 2012 - page 1-54
Object [title of the article]
Organism tested
Source [journal name]
1998
Acute Toxicity of Fire-Retardant and FoamSuppressant Chemicals to Early Life Stages of
Chinook Salmon (Oncorhynchus tshawytscha)
Fish
Environmental Toxicology and Chemistry, 17(8): 1589-1599
Transactions of the American Fisheries society. 129: 408418
Birds
Environmental Pollution, 148: 312-315
Birds
Erch Eviron Contam Toxicol 43: 330-337
N/A
J Phys Chem 9(3): 210-215
plants
Sci Cult, 46: 150-152
plants
Perspectives in cytology and genetics, 5: 349-352
Mice
N/A
Cytologia, 53: 485-489
American Elsevier Publishing Company, Inc. ISBN: 0-44441073-2
sheep
JAVMA. 203(8): 1176-1177
Fire-Trol LCA-F, Fire-Trol LCM-R and
Phos-Chek 259F, FireFoam 103B,
FireFoam 104, Fire Quench, ForExpan
S, Pyrocap B-136 and other chemicals.
N/A
N/A
Buhl KJ and Hamilton SJ
2000
Acute Toxicity of Fire-Control Chemicals,
Nitrogenous Chemicals and Surfactants to Rainbow
Trout.
Fish
Phos-Chek G75-F and Silv-Ex
N/A
N/A
Buscemi DM, Hoffman DJ, Vyas NB,
Spann JW and Kuenzel WJ
2007
Effects of Phos-Chek G75-F and Silv-Ex on redwinged blackbird (Agelaius phoeniceus) embryos.
Effects of Phos-Chek G75-F and Silv-Ex on
Developing Northern Bobwhite Quail (Colinus
virginianus)
The solubility of calcium sulphate in solutions of
other salts
Mitotic effects of superphosphate on somatic cells of
Allium sativum
Cytogenic effects of single super phosphate on
onion root tip cells.
Induction of Mitotic-Chromosome Anomalies in Mice
by Single Super Phosphate
Phos-Chek G75-F and Silv-Ex
N/A
N/A
Buscemi DM, Hoffman DJ, Vyas NB,
Spann JW and Kuenzel WJ
2002
No phosphates
N/A
N/A
Cameron FK and Brown BE
1905
superphosphate
N/A
N/A
Chaurasia LC anf Rahtor JS
1980
Single super phosphate
N/A
N/A
Chaurasia OP and Sinha Sp
1986
Single Super Phosphate
N/A
N/A
Chaurasia OP and Sinha SP
1988
Phosphorous
N/A
N/A
Corbridge DEC
1974
SUPERPHOSPHATE
N/A
N/A
East NE
1993
The Structural Chemistry of Phosphorus.
Accidental superphosphate fertiliser poisoning in
pregnant ewes.
Unspecified
N/A
N/A
Elmstahl S et al
1998
Increased Incidence of Fractures in Middle-aged and
Elderly Men with low intakes of phosphorus and zinc human
Osteoporos Int 8:333-340
1976
The Chemistry of Phosphorus. Environmental,
organic, inorganic, biochemical and spectroscopic
aspects.
N/A
John Wiley and Sons. ISBN: 0-470-23869-0
rabbits, fish
EPA/600/8-89/072
Phosphorous
N/A
N/A
Phosphorous trichloride, phosphorous
pentachloride, phosphorous
oxychloride, phosphoryl chloride,
phosphorous sesquisulfide
N/A
N/A
sodium ammonium phosphate
N/A
13011-54-6
No IP substances investigated
N/A
Fire-Trol GTS-R, Fire-Trol LCG-R, PhosChekD75-F, Phos-Chek WD-881 and
Silv-Ex.
N/A
Fire-Trol GTS-R, Fire-Trol LCG-R, PhosChekD75-F, Phos-Chek WD-881 and
Silv-Ex.
Emsley J and Hall D
EPA
1990
Fazekas, IG
1954
N/A
Freeman L and Fowler I
1953
EPA Summary review of health effects associated
with elemental and inroganic phosphorous
compounds: Health issue assessment
Enlargement of parathyroid glands by simple acidic
compounds
Toxicity of combinations of certain inorganic
compounds to Daphnia magna stratus.
N/A
Gaikowski MP, Hamilton Sj, Buhl KJ,
McDonald SF and Summers CH
1996
Acute toxicty of Firefighting Chemical Formulations
to Four Life Stages of Fathead Minnow.
N/A
N/A
Gaikowski MP, Hamilton Sj, Buhl KJ,
McDonald SF and Summers CH
1996
1986
No IP substances investigated
ammonium pyrophosphate ? (NH4)2
HP2O7 . H2O
N/A
N/A
Gersich FR and Hopkins DL
N/A
N/A
Iron compounds
N/A
N/A
Gilliam J.W. And Sample E.C.
1968
Gold MD(Ed.) Hoppe JO, Marcelli GMA,
Tainter ML
1955
Acute Toxicity of Three Fire-Retardant and Two FireSuppressant Foam Formulations to the Early Life
Stages of Rainbow Trout (Oncorhynchus mykiss)
Site-specific acute and chronic toxicity of ammonia
to Daphnia magna straus
Hydrolysis of pyrophosphates in soils: pH and
biological effects
Progress of Medical Science. Therapeutics: A review
of the toxicity of iron compounds.
rabbits
J. Anim. Sci. 80:1690-1695
Daphnia
Sewage and Industrial wastes. 25(10): 1191-1195
Fish
Ecotoxicology and Environmental safety. 34: 252-263
Fish
Environmental Toxicology and Chemistry, 15(8): 1365-1374
Daphnia
Environmental Toxicology and Chemistry, 5(5): 443-447
soils
soil science 106(5): 352-357
various
Am J Med Sci. 230(5): 558-571
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
16th April 2012 - page 1-55
Object [title of the article]
Organism tested
Source [journal name]
rat hepatocytes
Cell biology and Toxicology. 3(2): 127-
No IP substances investigated
N/A
N/A
Hsia MTS
1987
Use of scintillometric quantitation of unscheduled
DNA synthesis in isolated rat hepatocytes for the
screening of genotoxic agents.
cyclophosphates
N/A
N/A
Kalliney SY
1972
Cyclophosphates
n/a
Topics in Phosphorous Chemistry, 7: 255-309
various
Unidentified inorganic phosphate
N/A
N/A
N/A
N/A
1989
1978
Inorganic phosphate materials
Mutagenicity of metal compounds.
N/A
microorganisms
Unknown source. 215-216
no IP substances
N/A
N/A
Kanazawa T
Kanematsu N and Kada T
Kempf CA, Greenwood DA & Nelson
VE
1937
Studies relating to the toxicity of fluorine compounds mice, rats, dogs
Various
N/A
N/A
Kent JA (Ed)
1992
triammomium pyrophosphate
monohydrate TPP
N/A
N/A
Khasawneh F.E. Et al
1974
triammomium pyrophosphate
monohydrate TPP
N/A
N/A
Khasawneh F.E. Et al
1979
Single Super Phosphate
N/A
N/A
1982
Mg-substituted HAP
N/A
N/A
Konar SK and Sarkar SK
Landi E, Logroscino G, Proietti L,
Tampieri A, Sandri M and Sprio S
Phos-Chek G75-F
N/A
N/A
Larson Dl and Newton WE
Fire-Trol GTS-R and Phos-Check D75-R
N/A
N/A
Little EE and Calfee RD
UNKNOWN
N/A
N/A
Locke A
Chlorinated trisodium phosphate
Chlorinated trisodium phosphate
N/A
N/A
N/A
N/A
Loveday KS et al
Loveday KS et al
Materials science monographs. 52 (Book)
J. Lab. Clin. Med. 22:1133-1137
N/A
Riegel's handbook of industrial chemistry. 9th Ed
reactions of ammonium ortho- and polyphosphate
fertilizer in soil: I Mobility of Phosphorus
soils
soil sci soc amer proc 38: 446-451
reactions of ammonium ortho- and polyphosphate
fertilizer in soil: II Hydrolysis and reactions with soil
soil
soil sci soc amer proc 43: 52-58
Fish
Geobios, 10: 6-9
2008
Acute toxicity of agricultural fertilizers to fishes.
Biomimetic Mg-substituted hydroxyapatite: from
synthesis to in vivo behaviour.
N/A
J MaterSci: Mater Med. 19:239-247
1996
Effects of Fire Retardant Chemicals and Fire
Suppressant Foam on North Dakota Prairie
Vegetation.
Plants
Proceedings of the North Dakotak Academy of Science,
50: 137-144
1990
Environmental Persistence and Toxicity of FireRetardant Chemicals, Fire-Trol GTS-R and PhosChek D75-R to Fathead Minnows
Zooplankton Responses to Acidification: A Review
of Laboratory Bioassays
Zooplankton
Water, Air and Soil Pollution, 60 :135-148
1986
In vitro cytogenic testins using sister chromatid
exchange and chromosome aberration endpoints in
CHO cells.
Chinese hamster (CHO
cells)?
Abstracts of the eighteenth annual meeting of the
evironmental mutagen society.
1987
In vitro cytogenic testins using sister chromatid
exchange and chromosome aberration endpoints in
CHO cells.
Chinese hamster (CHO
cells)?
Abstracts of the eighteenth annual meeting of the
evironmental mutagen society.
Chinese hamster CHO
cells
N/A
Environmental and Molecular Mutagenesis, 13: 60-94
Clinical principles of environmental health : 1053-62
Fish
Forest, wildlife and range experiment station. Bulletin No. 3
Bacteria
Mutation Research. 155: 49-51
fish
Environmental toxicology and chemistry, 5(5): 437-442
Chlorinated trisodium phosphate
Not an IP paper
N/A
N/A
N/A
N/A
Loveday KS et al
Lowe J and Sullivan JB Jr
1989
1992
Ammmonium flurophosphate
N/A
N/A
MacPhee C and Ruelle R
1969
Inorganic phosphates not investigated
N/A
N/A
Marzin DR and Phi HV
1985
No IP substances investigated
N/A
N/A
Mayes MA
1985
Chromosome Aberration and Sister Chromatid
Exchange Tests in Chinese Hamster Ovary Cells In
Vitro: II. Results With 20 Chemicals
Hazardous materials toxicology
Lethat effects of 1888 chemicals upon four species
of fish from Western North America
Study of the mutagenicity of metal derivatives with
Salmonella typhimurium TA102.
Acute and chronic toxicity of ammonia to freshwater
fish: a site specific study
Fish
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Fire-Trol GTS-R, Fire-Trol LCG-R, PhosChekD75-F, Phos-Chek WD-881 and
Silv-Ex.
Study
Year
Authors
N/A
CAS Nr.
N/A
Fire-Trol GTS-R, Fire-Trol LCG-R, PhosChekD75-F, Phos-Chek WD-881 and
Silv-Ex.
UNKNOWN
Polyphosphate and superphosphate
(fertilisers)
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Inorganic phosphates not investigated
McDonald SF, Hamilton SJ, Buhl KJ
and Heisinger JF.
McDonald SF, Hamilton SJ, Buhl KJ
and Heisinger JF.
Menzel
1996
1997
1932
N/A
Miner G and Kamprath E
Morris R, Taylor EW, Brown DJA and
Brown JA
1971
1987
N/A
N/A
Nishimura M and Umeda M
1978
Phos-Chek XA
N/A
N/A
Norris LA et al
1978
Sodium ammonium phosphate
N/A
N/A
Pagano DA and Zeiger E
1992
Inorganic phosphates not investigated
N/A
N/A
Paton GR and Allison AC
1972
N/A: sodium fluoride
N/A
N/A
Pindborg J
1957
phosphate carriers
N/A
N/A
Plate H and Mathews D
1984
16th April 2012 - page 1-56
Object [title of the article]
Organism tested
Source [journal name]
Acute Toxicity of Fire Control chemicals to Daphnia
magna (Straus) and Selenastrum capricornutum
(Printz)
Daphnia, algae
Ecotoxicology and environmental safety, 33: 62-72
Amiphod
N/A
Environmental Toxicology and Chemistry, 16(7): 1370-1376
Ztschr. Elektrochem. 58(5): 283-299
N/A
Soil sci Soc Am J. 35: 927-930
Acute Toxicty of Fire-Retardant and FoamSuppressant Chemicals to Hyalella Azteca
(Suassure)
Sieg alkaliphosphates
Reactions and availability of banded polyphosphate
in field studies
Acid Toxicity and Aquatic Animals.
Mutagenic effects of some metal compounds on
cultured mammalian cells.
A Report of Research on the Behaviour and Impact
of Chemical Fire Retardents in Forest Streams
Conditions for detecting the mutagenicity of divalent
metals in Salomnella typhimurium.
Chromosome damage in human cell cultures
induced my metal salts.
The effect of 0.025 and 0.0125 dietary sodium
fluoride on the rat kidney
Relative safety of common fertilizer materials for
planter application
Cambridge University Press. ISBN: 978-0-521-33435-8
Unknown source
N/A
N/A
bacteria
Environmental and Molecular mutagenesis. 19: 139-146
Mutation research. 16(3): 332-336
Rat
N/A
Odont Rev. 8: 331-334
Abstr Pap Am Chem Soc 188th American Chemical
Society Meeting Piladelphia Aug 26-31 1984
zinc phosphates'
N/A
N/A
Salmon JE and Terrey H
1950
superphosphate
N/A
N/A
Sarkar SK
1989
The systems zinc oxides - phosphoric oxide - water
and manganous oxide-phosphoric oxide-water at
temperatures between 25° and 100°
Toxicity Evaluation of Superphosphate on Some
Aquatic Invertebrates Exposed to Temperature.
1971
Initial submission: rabbit eye irritant classification
study with sodium hexametaphosphate with cover
letter dated 082892
Rat
Stauffer Western RC NTIS OTS0545336 (T-1729)
1971
Initial submission: rabbit eye irritant classification
study with sodium hexametaphosphate with cover
letter dated 082892
Rabbit
Stauffer Western RC NTIS OTS0545336 (T-1729)
1971
1993
Initial submission: rabbit eye irritant classification
study with sodium hexametaphosphate with cover
letter dated 082892
Chemically induced birth defects.
Rabbit
N/A
Stauffer Western RC NTIS OTS0545336 (T-1729)
2nd edition. 842-869
sodium hexametaphosphate :
ESCOFOS (not applicable to SHMP substance is a formulation)
sodium hexametaphosphate :
ESCOFOS (not applicable to SHMP substance is a formulation)
sodium hexametaphosphate :
ESCOFOS (not applicable to SHMP substance is a formulation)
No IP substances investigated
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Saylor JF and Kamienski FX
Saylor JF and Kamienski FX
Saylor JF and Kamienski FX
Schardein JL
n/a
J Chem Soc. Unknown vol: 2913-2924
zooplankton, worm, larvae
and molluscs
J Environ Biol, 11(2): 97-100
Fire Retardants
N/A
N/A
Seymour B, Collet NG
2009
Effects of Fire Retardant Application on Heathland
Surface-Dwelling Ant Species (Order: Hymenoptera;
Family Formicidae) in Victoria Australia
Invertebrates
No inorganic phosphates investigated.
N/A
N/A
1985
Acute oral toxicity and repellency of 933 chemicals to Mice
House and Deer mice
unknown
Aluminium
N/A
N/A
N/A
N/A
Shafer EW and Bowles WA
Shpunt SY, Belopolskii AP & Shulgina
MN
Sjogren B and Elinder CG
1951
1993
unknown
Aluminium
No IP substances reported
N/A
N/A
Smith FA , Gardner DE, Leone NC and
Hodge HC
1960
N/A
N/A
N/A
Spencer H
1975
The effects of the absorption of fluoride. V. The
chemical determination of flouride in human soft
tissues following prolonged ingestion of fluoride at
various levels
Effect of calcium and phosphorus on fluoride
metabolism in man.
Forest Ecology Management, 257: 1261-1270
Archives of Environmental Contamination and Toxicology.
14:111-129
n/a
N/A
Zh Prikl Chim. 24: 404-412
Human
AMA Arch. Indust. Health. 21: 330-332
human
J. Nutr. 105(6): 733-740.
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Nordic expert group. Arbete och Halse. 1:55-84
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Sub ID
CAS Nr.
Sodium glycerophosphate
N/A
N/A
Spencer H
1978
Phosphate berlinite (AIPO4)
N/A
N/A
Stacy
1958
Phosphate ore
N/A
N/A
Stayner LM et al
Not applicable - review of assays to
determine available phosphorous
N/A
N/A
DCP (not chemical – precipitated from
bone) compared to commercially
available forms.
N/A
Calcium aluminium phosphate
16th April 2012 - page 1-57
Object [title of the article]
Organism tested
Source [journal name]
Effect of phosphorus on the absorption of calcium
and on the Calcium balance in Man.
human
J. Nutr. 108:447-457
1985
Tissue changes in rats lungs caused by hydroxides,
oxides and phosphates of aluminium and iron
rat
A retrospective cohort mortality study of a phosphate
fertilizer production facility
Human
Arch Environ Health, 40: 133-138
Sullivan TW and Douglas JH
1990
Phosphorious bioassays - Developments in five
decades
N/A
Presented at the Pitman-Moore Nutrition for the Nineties
Conference, Bloomington, MN, September 17, 1990. 18-
N/A
Sullivan TW et al
1994
turkey
Poultry Science. 73: 122-128
N/A
N/A
Taylor AW and Gurney EL
1964
N/A
Soil Sci. Soc. Am J. 28:63-65
condensed phosphates
Radiolabelled phosphate
N/A
N/A
N/A
N/A
Thilo E
Tomatis
1955
1973
water and soil
N/A
Angewandte Chemie, 67:141-185
WHO
condensed phosphates
N/A
N/A
Topley B
1949
Serum phosphorous
N/A
N/A
Tornblom N
1949
Ferrous and Ferric ammonium sulphate
UNKNOWN
orthophosphate, pyro- and
tripolyphosphate mixtures
N/A
N/A
N/A
N/A
1938
1954
N/A
N/A
Underwood EJ
Van Wazer JR
Van Wazer JR, Griffith EJ and
McCullough JF
Octocalcium phosphate
N/A
N/A
Verbeeck RMH and Devenyns JAH
1990
Physical properties
n/a
On the functional relationship between the pituitary
gland and the parathyroids
A Comparison of Ferrous and Ferric Iron in the
Nutrition of the Rat.
Rat
?
N/A
Analysis pH titration of soluble phosphates and their
mixtures
The effect of the solution Ca / P ratio on the kinetics
of dissolution of octocalcium phosphate.
1977
Acute toxicity and skin corrosion data for some
organic and inorganic compounds and aqueous
solutions.
The mechanism of the hydrolysis of polyphosphates.
VI. The effect of cations on the hydrolysis of cyclo-triand cyclo-tetraphosphates
N/A
No IP substances investigated
N/A
N/A
Vernot EH et al
1954
sodium cyclo-triphosphate, sodium
cyclo-trimetaphosphate
n/a
n/a
Watanabe M
1982
calcium tetraphosphate
N/A
N/A
Watanabe W, Suzumori H, Maeda M
and YamadaT
1980
sodium and potassium phosphates
UNKNOWN
N/A
N/A
N/A
N/A
Wendrow B & Kobe KA
Wenger P
1954
1911
Biological value of bone-precipitated dicalcium
phosphate in turkey starter diets.
The dissociation of calcium aluminium phosphate,
CaAlH(PO4)2.6H20.
Hydrolysis of condensed phosphates in aqueous
solution
Transplacental Carcinogenesis
The synthesis and decomposition of calcium
tetraphosphate
The alkali orthophosphates. Phase equilibria in
aqueous solution.
Tables
Rabbit, rat
N/A
Wheeler IP
Rat
1991
chlorinated trisodium phosphate
N/A
N/A
Zeiger E et al
1988
Journal of Crystal Growth. 102: 647-657
Toxicology and Applied Pharmacology. 42:417-423
Bulletin of the Chemical Society of Japan. 55(12): 37663769
Prepared by Norecol Environmental Consultants Ltd on
behalf of Manager, Fire Management Forest Protection
Branch British Columbia.
N/A
Wien EM and Van Campen DR
Anal. Chem. 26: 1755 – 1760
Chem Rev. 54: 891-924
Annuelles. 2: 411-413
Toxicological Review of Fire Fighting Foams.
N/A
Journal of Nutrition, 16(3): 299-308
J Phys Chem. 58: 739
n/a
N/A
Ferric Iron Absorption in Rats: Relationship to Iron
Status, Endogenous Sulfhydryl and Other Redox
Components in the Intestinal Lumen
Salmonella Mutagenicity tests: IV. Results from the
testing of 300 Chemicals
N/A
Acta Endocrinol Suppl, 4: 1-76
Bulletin of the Chemical Society of Japan. 35: 2663-2665
1989
ferric chloride
Q Rev Chem Soc. 3:345-370
N/A
Chemonics Fire Foam 103
Monsanto Phos-Chek WD 861, 881
Wormal SILV-EX
Angus Forexpan
3m FB 100
N/A
J Path Bact 77: 417-426
Salmonella
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Journal of Nutrition 121(6): 825-831
Environmental and Molecular Mutagenesis. 11 (suppl 12) 1158
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
Sub ID
CAS Nr.
octacalcium phosphate
N/A
N/A
Zhang J
1992
Kinetics and mechanisms of octocalcium phosphate
at 37°C.
polyphosphate'
n/a
n/a
Kornberg A
1995
Inorganic polyphosphate: toward making a
forgotten polymer unforgettable
various
n/a
n/a
Deshpande SS
2002
unknown
n/a
n/a
Laflamme GH & Jowsey J
1972
16th April 2012 - page 1-58
Organism tested
Source [journal name]
J. Phys. Chem. 96: 5478-5483
n/a
J. Bacteriol. 1n(3):491-496.
various
n/a
dogs
The Journal of Clinical Investigation. 51: 2834- 2840
Effects of biological type of beef steers on
vitamin D, calcium, and phosphorus status
cows
J Anim Sci 2004. 82:2043-2049.
Handbook of Food Toxicology
Bone and Soft Tissue Changes with Oral
Phosphate Supplements
phosphorus'
n/a
n/a
J. L. Montgomery, J. R. Blanton,
Jr., R. L. Horst, M. L. Galyean, K. J.
Morrow, Jr., D. B. Wester and M. F.
Miller
2004
various
n/a
n/a
NRC
2005
NRC Mineral tolerance of animals
various
n.a
no IP substance tested
n/a
n/a
Charles OW
1975
The effect of calcium source and level on egg
shell quality
hens
Poultry Science. 54: 1744
no IP substance tested
n/a
n/a
joyce Jr, Pierce KR, Romane WM
and Baker JM
1971
horse
Journal of the American vetinary medical association.
151(12): 2033-2043
various polyphosphates
n/a
n/a
Maier, S. K.
1999
n/a
TOC( SUPPL: *)
unknown
n/a
n/a
Radkowski, М. and Kafel, S.
1985
inorganic phosphate'
n/a
n/a
Strange, J. R.
various
various
n/a
n/a
n/a
n/a
Sodium Ferric Pyrophosphate
N/A
ferric sodium pyrophosphate
N/A
clincial study of nutritional secondary
hyperparathyroidism in horses.
Die antimikrobielle Wirkung von
Polyphosphaten. Ph.D. thesis. Technical
University of Munieh. Freising, Germany.
1977
Effect of polyphosphates оп lactic acid bacteria
of processing importance
unknown
Effect of High Levels of Inorganlc Phosphate on
Aquatic Organisms ln Phosphate-Rlch
Environments
unknown
Gov. Rep. Announce. Index (U.S) NTIS PB263290.
77(9):181
Weinberg ED
Ellinger RH
1974
1972
Secondary Metabolism: Control by Temperature
and inorganic phosphate
n/a
CRCF phosphates as food ingredients
n/a
Developments in Industrial Microbiology. Handbook.
Chap 8
Handbook
N/A
Brusick D
1975
N/A
Brusick D
1975
Mutagenic Evaluation of Compound FDA 73-82
010045871 Sodium Ferric Pyrophosphate
Teratologic evaluation of FDA 73-82 ferric sodium
pyrophosphate in mice and rats.
Med Weter 400:328-329
Yeast and Bacteria
NTIS
mice and rats
NTIS
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Object [title of the article]
Organism tested
Source [journal name]
turkey
N/A
Poultry Sci. 55:1691-1699
CRC Handbook of chemistry and physics
N/A
J. Nutr. 52:115-125.
Hydrolysis of condensed phosphates during
aerobic biological sewage treatment.
microbes
Water Research, Pergamon Press, 1: 247-254
Hydrolysis of condensed phosphates during
aerobic biological sewage treatment.
N/A
Water Research, Pergamon Press, 1: 247-254
N/A
N/A
Annu. Rev. mater. Sci. 21:65-92
N/A
1996
Crystal chemistry of oligophosphates
Topics in Phosphate Chemistry
The Merck Index, An Encyclopaedia of Chemicals,
Drugs and Biologicals
1995
Crystal Chemistry of Condensed Phosphates.
N/A
Sub ID
CAS Nr.
N/A
Various
Struwe FJ, Sullivan TW and Kuhl HJ
Various
n/a, 18
Various
Lide D R.
1976
2009
various
various
various
Gillis MB et al
1954
Evaluation of phosphated egg shell and fertilizer
phosphates in turkey starter diets1,2,3
CRC Handbook of chemistry and physics
Studies on the biological value of inorganic
phosphates.
polyphosphate' 'orthophosphate'
Various
Various
Finnstein M and Hunter J
1967
pyrophosphate, tripolyphosphate
various
various
Finstein MS and Hunter JV
1967
various
various
various
various
various
various
Averbuch Pouchot MT and Durif A
Averbuch-Pouchot MT and Durif A
1991
1996
Various
VARIOUS
Various
Budavari S et al
various
various
various
Durif A
concentrated super phosphate,
diammonium phosphate
various
16th April 2012 - page 1-59
Twelfth Edition Merck & Co., Inc. Whitehouse Station, NJ.
chick
J. Nutr. 35(2):195-207
Franklin Institute Research Laboratories 806-C3378-017301.
Volume 18
1996
1912
Action Physiologique et Toxicologique des
Phosphates Condensés.
The utilization by the Chick of phosphorus from
different sources.
GRAS (generally recognised as safe) food
ingredients - Phosphates.
Lewis – Sax Dangerous Properties
Food Antioxidants. technological, toxicological and
health perspectives
Modern Inorganic Chemistry
N/A
N/A
N/A
N/A
1956
1972
Utilization of phosphorus from various phosphate
supplements in chicks
Nonenzymic hydrolysis at phosphate tetrahedra
chicken
N/A
Poultry Sci. 35: 627-649
Various
various
various
various
various
Gillis MB et al
1949
Various
Various
various
Various
Various
n/a
GRAS
1973
Lewis RJ
various
various
various
various
various
various
Madhavi DL, et al
Mellor JW
various
Various phosphates
various
Various
various
Various
Motzok I, Arthur D and Branion HD
osterheld
1958
Impremerie Nationale J.P.831041 : 57-97
Various substances
sodium phosphates'
various
various
various
various
Siedell A
Thomsen J
1940
1888
various
various
various
Van Wazer JR
1955
Solubilities of Inorganic and Metal Organic
Compounds. A Compilation of Quantitative Solubility
Data from the Periodical Literature.
N/A
N/A
Structure and properties of the condensed
phosphates. X. general structural theory
N/A
1950
Structure and properties of the condensed
phosphates. I. some general considerations about
phosphoric acids
various
Plenum Press, New York.
Ebel JP
various
various
Van Wazer JR
various
various
various
Van Wazer JR
1950
various
various
various
Van Wazer JR
1956
Various
Various
N/A
WHO
1970
N/A
Structure and properties of the condensed
phosphates. II. A theory of the molecular structure of
sodium phosphate glasses
N/A
Existence of ring phosphates higher than the
tetrametaphosphate
N/A
Toxicological evaluation of some extraction solvents
and certain other substances
Various
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Third Edition, Volume 1, New York, D. Van Nostrand
Company Inc
Dritter Band. Wassrige Lusung und hydratbildung
J Am Chem Soc, 77: 6140-6144
J Am Chem Soc, 72(2): 639-644
J Am Chem Soc 72(2): 644-647
J Am Chem Soc 78: 1772
FAO Nutrition Meetings Report Series No. 48A.
WHO/FOOD ADD/70.39
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
tripolyphosphate. 'pyrophosphate'
Sub ID
CAS Nr.
Various
Various
Authors
Study
Year
Shannon JE and Lee GF
1966
Object [title of the article]
16th April 2012 - page 1-60
Organism tested
Hydrolysis of condensed phosphates in natural
waters
N/A
Source [journal name]
Air & Wat. Pollut. Int. J 10, 735-756
Various
Various
N/A
Various
various
Various
Bibra Toxicology Advice and Consulting 1993
Food additives in Europe 2000 - status of safety
assessments of food additives presently permitted in
the EU.
Various
Phosphoric Acid and Common Inorganic
Phosphates
various
Various phosphates
various
various
Corbridge DEC
1974
The structural chemistry of phosphorus.
N/A
Elsevier Scientific Publishing Company.
Phosphates; proposed affirmation of and deletion
from GRAS status as direct and human food
ingredients.
rats
Vol 44, No.10, 244
Anon
~2000
Various
Various
Various
Federal Register
1985
Various
various
Various
GFSA
2008
Various
Various
Various
Jelleff Carr C.
1975
Various
various
Various
Lewis RJ
Various
various
various
2007 Hawley's Condensed Chemical Dictionary
Osterheld RK
Various
Various
Toxicity Profile.
Http://www.codexalimentarius.net/gsfaonline/groups/details
.html?id=18&lang-en
n/a
N/A
Federation of American Societies for Experimental
Biology. PB262651.
N/A
Hawley's condensed chemical dictionary, 15th edition.
1972
Nonenzymic hydrolysis at phosphate tetrahedral.
1982
INTERNATIONAL PROGRAMME ON CHEMICAL
SAFETY WORLD HEALTH ORGANIZATION
TOXICOLOGICAL EVALUATION OF CERTAIN
VETERINARY DRUG RESIDUES IN FOOD WHO
FOOD ADDITIVES SERIES 17. 1982.
2009
effect of single superphosphate fertiliser on
survival and respiratory dynamics of Nile Tilapia,
Oreochromis niloticus (Actinopterygh:
perciformes:cichildae)
Fish
Acta Ichthyologica et piscatoria. 39(2): 103-110
WHO IPCS INCHEM Toxicological
evaluation food additives JECFA no 17
Various
GFSA Online Food Additive Group Details for
Phosphates.
Evaluation of the health aspects of phosphates as
food ingredients.
Food additives in Europe 2000
N/A
Single superphosphate (SSP)
Omoregie E, Ajima MNO, Keke RI
and Wieski K
No IP substance - refers to
Phosphate only
Abdolzadeh A, Wang X, Veneklaas
EJ and Lambers H
2010
effects of phosphorous supply on growth,
phosphate concentration and cluster-root
formation in three Lupinus species
plants
Annals of Botany. 105:365-374
No IP substance - refers to
Phosphate only
Ohnishi M and Razzaque MS
Dietary and genetic evidence for phosphate
toxicity accelerating mammalian aging
mice
The FASEB Journal.
2010
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
monoammonium phosphate
De Boer G, Buchanan-Smith JG,
Macleod GK & Walton JS
Manganese phosphate (hereaulite)
Mn5(PO4)2[PO3(OH)]2.4H2O
TESTED AS PART OF A
MIXTURE CONTAINING
MANGANESE SULPHATE
34
Linda A. Beaupre, Fariba Salehi,
Joseph Zayed
Manganese phosphate' identity not
defined
33,34,35
18718-07-5
35
51349-94-1
manganese hydrogen phosphate
35
51349-94-1
manganese hydrogen phosphate
35
51349-94-1
34
18718-07-5
Erikson KM, Shuber RL , Aschner
M
J Dairy Sci 64:2370-2377
2004
Physical and Chemical Characterization of Mn
Phosphate/Sulfate Mixture Used in an
Inhalation Toxicology Study
n/a
Inhalation Toxicology, 16:231–244, 2004
rat
The journal of nutrition, 16(3):
n/a
SOIL SCI. SOC. AM. J., VOL. 49, PG761-767
n/a
SOIL SCI. SOC. AM. J., VOL. 50,
1985
1986
2002
1968
Manganese-phosphate reactions in aqueous
systems and the effects of applications of
monocalcium phosphate on the availablity of
manganese to oats in an alkaline fen soil
No IP substances tested - MnSO4
Erikson KM, Dorman DC, Lash LH
and Ashner M
14154-09-7
Heintze SG
OLFACTORY TRANSPORT: A DIRECT
ROUTE OF DELIVERY OF
INHALED MANGANESE PHOSPHATE TO
THE RAT BRAIN
rat
Influence of Particle Solubility on the Delivery of
Inhaled Manganese
to the Rat Brain: Manganese Sulfate and
Manganese Tetroxide
Pharmacokinetics Following Repeated (14-Day)
Exposure
rat
2008
2002
Erikson, K.M., Dorman, D.C., Lash,
L.H., Aschner, M.
2007
33
The production of manganese rickets in rats
Diffraction Patterns and Solubility Products of
Several Divalent Manganese Phosphate
Compounds
Manganese Phosphate Equilibrium
Relationships in Soils
Glutamate/Aspartate Transporter (GLAST),
Taurine Transporter and Matallothionein mRNA
Levels are differentially altered in astrocytes
exposed to manganese chlroide, manganese
phosphate or manganese sulphate.
Manganese Inhalation by Rhesus Monkeys is
Associated with Brain Regional Changes in
Biomarkers of Neurotoxicity
Duration of airborne-manganese exposure in
rhesus monkeys is
associated with brain regional changes in
biomarkers of neurotoxicity
No IP substances tested - MnSO4
trimanganese bis(orthophosphate)
Source [journal name]
1981
David C. Dorman, Melanie F.
Struve, R. Arden James, Marianne
W. Marshall, Carl U. Parkinson, and
Brian A. Wong
2001
No IP substances tested
manganese phosphate' (MnPO4)
F. W. BOYLE, JR., AND W. L.
LiNDSAY
F. W. BOYLE, JR., AND W. L.
LINDSAY
David C. Dorman; Karrie A.
Brenneman; Anna M. McElveen;
Sean E. Lynch; Kay C. Roberts;
Brian A.
Wong
Organism tested
Responses of Dairy Cows Fed Alfalfa Silage
Supplemented with Phosphorus, Copper, Zinc,
and Manganese
cows
Blumberg H, Shelling DH, Jackson
DA
1938
manganese hydrogen phosphate
Object [title of the article]
16th April 2012 - page 1-61
Journal of Toxicology and Environmental Health, Part
A, 65: 20, 1493 — 1511
Toxicology and Applied Pharmacology 170, 79–87
Cell cultures derived
from rat brains
NeuroToxicology 23 281-288
Rhesus Monkey
Tox Sci. 97:459-466.
Rhesus Monkey
NeuroToxicology 29 (2008) 377–385
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Plant and Soil XXIX, no. 3
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Manganese phosphate (hereaulite)
Mn5(PO4)2[PO3(OH)]2.4H2O
TESTED AS PART OF A
MIXTURE CONTAINING
MANGANESE SULPHATE
34
Object [title of the article]
Organism tested
Source [journal name]
18718-07-5
Fariba Salehi, Daniel Krewski,
Donna Mergler, Louise Normandin,
Greg Kennedy,Suzanne Philippe,
and Joseph Zayeda,
2003
Bioaccumulation and locomotor effects of
manganese phosphate/sulfate
mixture in Sprague-Dawley rats following
subchronic (90 days)
inhalation exposure
Rat
Toxicology and Applied Pharmacology 191 (2003)
264–271
Fariba Salehi, Louise Normandin,
Daniel Krewski, Greg Kennedy,
Suzanne Philippe and
Joseph Zayed
2006
Neuropathology, tremor and electromyogram in
rats exposed to manganese phosphate/sulfate
mixture
Rat
A. P. Schwab
1989
CAS Nr.
Manganese phosphate (hereaulite)
Mn5(PO4)2[PO3(OH)]2.4H2O
TESTED AS PART OF A
MIXTURE CONTAINING
MANGANESE SULPHATE
34
18718-07-5
manganese phosphate' (MnPO4)
34
18718-07-5
No IP substances tested - MnSO4
Tisodium phosphate
4
7601-54-9
various
ferrous ammonium phosphate
phosphoric acid
various
manganese from all sources
Study
Year
Authors
16th April 2012 - page 1-62
J. Appl. Toxicol. 2006; 26: 419–426
Truong NV, Wilson GL and Andrew
CS
1971
Manganese-Phosphate Solubility Relationships
in an Acid Soil
n/a
MANGANESE TOXICITY IN PASTURE
LEGUMES I. EFFECTS OF CALCIUM AND
PHOSPHORUS
LEVELS IN THE SUBSTRATE
n.a
Plant and Soil 34, 309-330 (1971)
Czuba M, Zajic A, Poprzecki S,
Cholwea J, Woska S
2009
Effects of sodium phosphate loading on aerobic
power and capacity in off road cyclists.
human
Journal of Sports Science and Medicine
Expert group on vitamins and
minerals Secretariat
2003
EVM UK Expert Group Review of Phosphorus
EVM Review
N/A
Soil Sci. Soc. Am. J. 53:1654-1660 (1989).
N/A
10101-60-7
EFSA
EFSA: Scientific opinion on the safety of ferrous
ammonium phosphate as a source of iron
added for nutritional purposes to foods for the
general population (including food suplements)
and to foods for particular nutritional uses.
VARIOUS
48
various
7664-38-2
Kosting PR and Heins C
Lang K. et al
Corrosion of metals by phosphoric acid
Condensed Phosphates in Foods
metals
N/A
Industrial and Engineering Chemistry. (23)2. pg 140150
Textbook
Intellectual impairment in school-age children
exposed to manganese from drinking water
Children
Environmental Health Perspectives. 119(1) 138-143
34
n/a
Bouchard MF, Sauve S, Beabeau
B, Lengrand M, Brodeur ME,
Bouffard T, Limoges E, Bellinger
DC and Mergler D
1958
Publicly available published studies of which the IP Consortium has purchased a copyright copy
The EFSA Journal 2010; 8(5):1584
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
monocalcium phosphate, dicalcium
phosphate, tricalcium phosphate ,
hydroxyapatite
21,22,24
CAS Nr.
7758-23-8, 775793-9, 1306-06-5 Elliot JC
sodium fluoride
n/a
n/a
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
disodium fluorophosphate (SFP),
sodium fluoride
sodium fluoride
Study
Year
Authors
47
47
n/a
10163-15-2
10163-15-2
n/a
1994
Aardema MJ, Gibson DP &
LeBoeuf A
Structure and chemistry of the apatites and
other calcium orthophosphates
Sodium fluoride-induced chromosome
aberrations in different stages
of the cell cycle: a proposed mechanism
1989
Organism tested
Source [journal name]
N/A
Studies in inorganic chemistry
Mutation Research, 223 (1989) 191-203
Cells
Baylink DJ, Duane PB, Farley SM &
Farley JR
1983
Monophosphate physiology: the effects of
fluoride on bone
bones
Caries Research. 17(1): 56-57
Broll H, Peichi P, Wlifert H
Effect of sodium monophosphate and calcium
on bone density and fracture rate in
osteoporosis
n/a
Lancet. 8: 1446-1447
rat
Bone
Brun LR, Roma SM, Perez F &
Rigalli A
Bucher JR, Hejtmancik MR, Toft
JD, Persing RL, Eustis SL &
Haseman JK
1990
Histological differences in bones of rats treated
with sodium fluoride (NaF) and sodium
monofluorophosphate (MFP)
2009
1991
disodium fluorophosphate (SFP),
sodium fluoride
47
10163-15-2
sodium fluoride
n/a
n/a
Delmas PD, Dupuis J, DuBoeuf F,
Chapuy MC & Meunier PJ
1990
Dunipace AJ, Zhang W, Noblitt TW,
Li Y & Stokey GK
1989
fluoride - unknown source
n/a
n/a
Ekstrand J
disodium fluorophosphate (SFP)
47
10163-15-2
oral phosphate' - not specified
?
n/a
Ericsson Y
1967
Broadus AE, Magee JS, Mallette
LE, Horst RL, Lang R, Jensen PS,
Gertner JM & Baron R
1983
n/a
n/a
Albanese R
sodium fluoride
Object [title of the article]
16th April 2012 - page 1-63
1978
1987
disodium fluorophosphate (SFP),
sodium fluoride
47
10163-15-2
Brun LR, Pera LI & Rigalli
2010
disodium fluorophosphate (SFP)
47
10163-15-2
Gron P and Ericsson Y
1983
Results and conclusions of the national
toxicology program's rodent carcinogenicity
studies with sodium fluoride
Treatment of Vertebral Osteoporosis with
Disodium Monofluorophosphate: Comparison
with Sodium Fluoride
Genotoxicity of fluoride in mouse sperm
morphology and micronucleus studies
Relationship between fluoride in the drinking
water and the plasma fluoride concentration in
man.
Int. J. Cancer: 48, 733-737
rats, mice
human
Journal of bone and mineral research. 5(1). 143-147
mouse
Journal of Dental Research. 68:334
human
Caries Research. 12: 123-127
Biological splitting of PO3F ions
N/A
A detailed evaluation of oral phosphate therapy
in selected patients with primary
hyperparathyroidism
Human
sodium fluoride and chromosome damage (in
vitro human lymphocyte and in vivo
micronucleus assays)
n/a
Bone morphometry and differences in bone
fluorine containing compounds in rats treated
with NaF and MFP
Caries Research: Monofluorophosphate
Perspectives. The compound and its past,
present and future applications.
Caries Research. 1: 144-152
Journal of Clinical Endocrinology and Metabolism.
56(5)
mutagenesis. 2(6): 497-499
Rat
Biomedicine & Pharmacotherapy (64)1-6
various
Caries Research. Vol 17, supplement 1
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Authors
Study
Year
Clement Internation Corporation
1993
CAS Nr.
No IP substances: Fluorides
disodium fluorophosphate (SFP)
47
10163-15-2
Duff EJ
1983
disodium fluorophosphate (SFP)
47
10163-15-2
Ericsson Y
1983
rock phosphate
disodium fluorophosphate (SFP)
N/A
N/A
47
10163-15-2
defluorinated phosphate
Object [title of the article]
Toxicological profile for fluorides, hydrogen
fluoride and fluorine
Reaction of monofluorophosphate with apatitic
substrates
Monofluorophosphate physiology: General
Considerations
16th April 2012 - page 1-64
Organism tested
Source [journal name]
various
Agency for Toxic Substances and Disease Registry.
U.S public health service.
N/A
Caries Research 17(1):77-90
various
Caries Research 17(1): 46-55
Erlacher L, Teufelsbauer H,
Bernecker P, Pietschmann P &
Weissel M
1993
Ganegoda GAP & Gunaratne SP
1986
Comparisons of serum fluoride levels after
administration of monofluorophosphate-calcium
carbonate or sodium fluoride: differences in
peak serum concentrations.
Human
Evaluation of Eppawala rock phosphate as a
phosphorus supplement in diets for growing
chickens and pigs
Chicken and pigs
1970
The effect of sodium monofluorophosphate and
sodium fluoride on bone immobilization in rats rat
Gedalia I, Hodge HC, Anaise J,
White WE & Menczel J
Hill WL, Hendricks SB, Jefferson
ME & Reynolds DS
Li Y, Heerema NA, Dunipace AJ &
Stookey GK
1937
Fluoride and monofluorophosphate analysis
monofluorophosphate utilisation in oral
preparations: laboratory observations
clastogenic activity of sodium fluoride to rat
vertebrael body-derived celss in culture
biochemistry of monofluorophosphate
treatment of postmenopausal oseoporosis with
sodium monofluorophosphate: preliminary
results of a long-term double blind placebocontrolled study
N/A
Caries Research. 17(1): 9-20
cells
Caries Research. 17(1):102-118
cells
n/a
Mutation Research. 368: 7-13
Caries Research. 17(1): 21-35
Human
proceedings of the forth international symposium on
oseoporosis . 452-7
Human
proceedings of the forth international symposium on
oseoporosis . 433-434
Human
rats
n/a
Caries Research . 17(1): 91-101
Caries Research. 17(1): 36-45
Caries Research. 17(1): 2-8
rats , humans
Pharmacology and Therapeutics in denistry. 5: 47-54
n/a - human teeth
Acta Odont Scand. 21:341-358
n/a
disodium fluorophosphate (SFP)
47
10163-15-2
Lindahl CB
1983
disodium fluorophosphate (SFP)
47
10163-15-2
Melberg JR
1983
sodium fluoride
disodium fluorophosphate (SFP)
N/a
n/a
47
10163-15-2
Mihashi M, Tsutsui T
Pearce EIF
1996
1983
disodium fluorophosphate (SFP)
47
10163-15-2
Reginster JY
1993
disodium fluorophosphate (SFP)
47
10163-15-2
Ringe JD, Schmidt R
1993
disodium fluorophosphate (SFP)
disodium fluorophosphate (SFP)
disodium fluorophosphate (SFP)
47
47
47
10163-15-2
10163-15-2
10163-15-2
Rolla G
Smith FA & Hodge HC
White WE
1983
1985
1983
disodium fluorophosphate (SFP)
47
10163-15-2
Ericsson Y & Patterson C
1980
Therapeutic experience with the combination
monofluorophosphate and calcium
Interaction of monofluorophosphate with plaque
and saliva
Toxicology of monoflurophosphate.
monofluorophosphate - its beginning
Studies on the hydrolysis and absorption of
monofluorophosphate ions
disodium fluorophosphate (SFP)
47
10163-15-2
Ericsson Y
1973
The mechanism of the monofluorophosphate
action on hydroxyapatite and dental enamel
1999
Metabolism of the complex
monofluorophosphate-alpha2-macroglobulin in
the rat
rat
10163-15-2
Esteban L, Rigalli A & Puche C
Calc. Tiss. Res. 5, 146-152
Ind. Eng. Chem., 29(11): 1299-1304
n/a
47
J. Natn. Sci. Coun. Sri Lanka. 14(2):251-260
Composition of defluorinated phosphate
n/a
Genotoxic effects of fluoride evaluated by sisterchromatid exchange
cells
sodium fluoride
disodium fluorophosphate (SFP)
1987
Clinical Investigations. 72: 1082-1085
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Mutation Research. 192: 191-201
Medicina. 59:15-156
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
disodium fluorophosphate (SFP)
47
10163-15-2
various forms of
monofluorophosphate - not SFP
n/a
n/a
Farley JR, Tarbaux NM, Lau KHW
&Baylink DJ
1987
Giavaresi G, Fini M, Gnudi S, Nicoli
Aldini N, Rocca M, Carpi A &
Giardino R
2001
disodium fluorophosphate (SFP)
47
10163-15-2
Glass RL, Peterson JK, Zuckerberg
DA & Naylor MN
1975
sodium fluoride - NaF
n/a
n/a
Hayashi N & Tsutsiu T
1993
Haydon GB, Hein JW & Gardner
DE
1951
disodium fluorophosphate (SFP)
47
10163-15-2
sodium fluoride - NaF
n/a
n/a
Kanematsu N
1985
sodium fluoride - NaF
n/a
n/a
Khali AM & Da'dara AA
1994
sodium fluoride - NaF
n/a
n/a
Kishi K & Tonomura A
sodium fluoride - NaF
n/a
n/a
Li Y, Dunipace A & Stookey GK
1987
sodium fluoride - NaF
n/a
n/a
1987
sodium fluoride - NaF
n/a
n/a
Li Y, Dunipace A & Stookey GK
Li J, Suzuki Y, Hayashi K &
Shimizu H
sodium fluoride - NaF
n/a
n/a
Li Y, Zhang W, Noblitt TW,
Dunipace AJ & Stookey GK
1989
disodium fluorophosphate (SFP)
47
10163-15-2
Muller P, Schmid K, Warnecke G,
Setnikar I & Simon B
1992
10163-15-2
Nordenberg D, Simkin A, Gedalia I
& Robin G
1971
disodium fluorophosphate (SFP)
47
1991
Object [title of the article]
16th April 2012 - page 1-65
Organism tested
monofluorophosphate is hydrolysed by alkaline
phosphatase and mimics the actions of NaF on
skeletal tissues, In vitro
n/a - in vitro study
Comparison of calcitonin, alendronate and
fluorophosphate effects on ovariectomised rat
bone
rat
Fluoride ingestion resulting from the use of a
monofluorophosphate dentrifice by children
Cell cycle dependenceof cytotoxicity and
clastogenicity induced by treatment of
synchronized human diploid fibroblasts with
sodium fluoride
Source [journal name]
Calcified Tissue International. 40:35-42
Biomed and Pharmacother. 55:397-403
human
British Dental Journal. 138:423-426
cells
Mutation Research. 290:290-302
n/a
J Dent Res. 30:466
Preliminary investigations of the effect of
sodium monofluorophosphate on salivary acid
production and hydroxy apatite solubility
Genetic toxicity of biomaterial. 2. DNA
damaging effects of sodium fluoride and other
fluoride compounds
The Genotoxic and Cytotoxic Activities of
Inorganic Fluoride in Cultured Rat Bone
Marrow Cells
bacteria
Jpn. J. Oral Biol. 27: 372-374
cells - rat bone marrow
Archives of Environmental Contamination and
Toxicology. 26:60-63
Cytogenic effects of sodium fluoride
cells
unknown
Absence of mutagenic and antimutagenic
activities of fluoride in Ames Salmonella assays bacteria
Lack of genotoxic effects of fluoride in the
mouse bone-marrow micronucleus test
cells - mouse
The genotoxic effect of sodium fluoride
Genotoxic evaluation of chronic fluoride
exposure: sister-chromatid exchange
study
Sodium fluoride-induced gastric mucosal
lesions: comparison with sodium
monofluorophosphate
Mutation Research, 190: 229-236
J Dent Res. 66: 1687-1690
cells/bacteria
Unknown
hamsters
Mutation Research, 227 :159-165
Human
Z Gastroenterol. 30:252-254
The effect of sodium fluoride and sodium
monofluorophosphate on the mechanical
properties of normal and osteoporotic rat bone. rat
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Isr J. Med. Sci . 7(3): 529-531
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
National Toxicology Program. US
Department of Heatlh and Human
Services. Public Health Service.
National Institute of Health.
Collins T.F.X, Sprando R.L, Black
T.N, Shackelford M.E, Bryant M.A,
Olejinik N, Ames M.J, Rorie J.I &
Ruggles D.I
Object [title of the article]
Organism tested
Source [journal name]
1990
Toxicology and carcinogenesis studies of
sodium fluoride (CAS No. 7861-49-4) in
F344/N rats and B6c3F1 mice (drinking water
studies)
rats, mice
NTP TR-393
2001
Multigenerational evaluation of sodium fluoride
in rats
rats
Food and Chemical Toxicology 39, 601-613
sodium fluoride - NaF
n/a
n/a
sodium fluoride - NaF
n/a
n/a
sodium fluoride - NaF
n/a
n/a
sodium fluoride - NaF
n/a
n/a
Sprando RL, Collins TFX, Black TN,
Rorie J, Ames MJ & O'Donnell M
1997
Collins T.F.X, Sprando R.L, Black
T.N, Shackelford M.E, Bryant M.A,
Olejinik N, Ames M.J, Rorie J.I &
Ruggles D.I
2001
sodium fluoride - NaF
n/a
n/a
Heindel J
sodium fluoride - NaF
n/a
n/a
sodium fluoride - NaF
n/a
n/a
Heindel J
1993
Collins, TFX, RL Sprando, ME
Shackelford, TN Black, MJ Ames,
JJ Welsh, MF Balmer, N. Olejnik &
DI Ruggles
1995
1994
Testing the potential of sodium fluoride to affect
spermatogenesis in the rat
RATS
Food and Chemical Toxicology. 35:881-890
Developmental toxicity of sodium fluoride
measured during multiple generations
Food and Chemical Toxicology 39, 867-876
NTIS PB94-142684
Developmental toxicity of sodium fluoride in rats rats
Food & Chemical Toxicity. 33(1): 951-960
human
Arzneim Forsch / Drug Research. 46(I): 531-533
rat
Arzneim Forsch / Drug Research. 44: 651-655
disodium fluorophosphate (SFP)
47
10163-15-2
Rigalli A, Morosano M & Puche RC 1996
disodium fluorophosphate (SFP)
47
10163-15-2
Rigalli A, Cabrerizo A, Beinlich AD
& Puche RC
Gastric and Intestinal Absorption of
Monofluorophosphate and Fluoride in the Rat
47
10163-15-2
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
SFP-calcium carbonate complex
47
n/a
10163-15-2
n/a
1994
RAT
Developmental toxicity of sodium fluoride (CAS
#7681-49-4) in Sprague-Dawley (CD) rats
RAT
Developmental toxicity of sodium fluoride (CAS
#7681-49-4) in New Zealand White (NZW)
rabbits
rabbit
Bioavailability of Fluoride Administered as
Sodium Fluoride or Sodium
Monofluorophosphate to Human Volunteers
disodium fluorophosphate (SFP)
16th April 2012 - page 1-66
NTIS PB95110193
Rigalli A, Alloatti R, Menoyo I &
Puche RC
1995
Rigalli A, Esteban L, Pera L &
Puche RC
1997
Rigalli A, Pera L, Morosano M,
Masoni A, Bocanera R, Tozzini T &
Puche RC
1999
Comparative Study of the Effect ofSodium
Fluoride and Sodium MonoJluorophosphate on
Glucose Homeostasis in the Rat
rat
Binding of Monofluorophosphate to alpha2Macroglobulin and C3
n/a
In postmenopausal osteoporosis the bone
increasing effect of monofluorophosphate is not
dependent on serum fluoride
human
Rigalli A, Ballina JC, Beinlich AD,
Alloatti R & Puche RC
1994
Pharmacokinetic Differences between Sodium
Fluoride and Sodium Monofluorophosphate and
Comparative Bone Mass Increasing Activity of
Both Compounds in the Rat
rat
Arzneim Forsch/Drug Res. 44(I).6:762766
1988
physiologie et pharmacocinetique du
monofluorophosphate disodique-carbonate de
calcium
Lettre du Pharmacologue. 2: 1-4
Rouveix B, Faurisson F
human
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Arzneimittelforschung. 45(3): 298-292
Calcified tissue international. 60:86-89
Medicina. 59:157-161
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Sub ID
CAS Nr.
Serbet JL, Richard P, Mennecier I,
Bisset JP & Loeb G
Study
Year
Object [title of the article]
Organism tested
Source [journal name]
1995
Monofluorophosphate Increases Lumbar Bone
Density in Osteopenic Patients: A DoubleMasked Randomized Study
Bioavailability of Fluoride Added to Baby
Formula and Milk
human
Osteoporosis Int 5:108-114
human
Caries Res. 16: 249-256
disodium fluorophosphate (SFP)
47
10163-15-2
sodium fluoride - NaF
n/a
n/a
Spak CJ, Ekstrand J & Zyberstein D 1982
1984
1984
sodium fluoride - NaF
n/a
n/a
Tsutsui T, Suzuki N, Ohmori M &
Maizumi H
sodium fluoride - NaF
n/a
n/a
Tsutsui T, Ide K & Maizumi H
n/a
Tsutsui T, Tanaka Y, Matsudo Y,
Uehama A, Someya T, Hamaguchi
F, Yamamoto H & Takahashi M
1995
sodium fluoride - NaF
n/a
16th April 2012 - page 1-67
Cytotoxicity, chromosome aberrations and
unscheduled DNA synthesis cultured human
diploid fibroblasts induced by sodium fluoride
cells
Induction of unscheduled DNA synthesis in
cultured human oral keratinocytes by sodium
fluoride
cells
No increases in chromosome aberrations in
human diploid fibroblasts following exposure to
low concentrations of sodium fluoride for long
times
cells
sodium fluoride - NaF
n/a
n/a
disodium fluorophosphate (SFP)
47
10163-15-2
Van Asten P, Darroudi F, Natarajan
AT, Terpstra IJ & Duursma SA
1998
disodium fluorophosphate (SFP)
47
10163-15-2
Villa A, Guerrero S, Cisternas P &
Mockeberg F
1989
hydrogen fluoride only tested
n/a
n/a
Voroshilin SI, Plotko EG,
Gatiyatullina EZ & Gileva EA
1973
Sodium Fluoride-induced Morphological and
Neaplastic Transformation, Chromosome
Aberrations, Sister Chromatid Exchanges, and
Unscheduled DNA Synthesis in Cultured Syrian
Hamster Embryo Cells
Cytogenetic effects on lymphocytes in
osteoporotic patients on long-term fluoride
therapy
Fluoride Bioavailability from Disodium
Monofluorophosphate Fluoridated Milk in
Children and Rats
Cytogenetic effect of inorganic fluorine
compunds on human and animal cells in vivo
and in vitro
disodium fluorophosphate (SFP)
47
10163-15-2
Zeiger E, Shelby MD & Witt KL
1993
Genetic toxicity of fluoride
various
disodium fluorophosphate (SFP)
47
10163-15-2
DePaola PF
1983
Clinical Studies of Monofluorophosphate
Dentifrices
various
hydroxyapatite
24
1306-06-5
Avnimelech Y, Moreno EC & Brown
WE
1972
calcium phosphate unspecified
n/a
n/a
disodium hydrogenorthophosphate
sodium phosphate (unspecified states neutral buffered)
3
7558-79-4
Tsutsui T, Suzuki N & Ohmori M
Bassett H
1984
1958
Bouchoud L, Fonzo-Christie C,
Sadeghipour F & Bonnabry P
Cade R, Conte M, Zauner C, Mars
D, Peterson J, Lunne D, Hommen
& Packer D
2010
1984
Mutation Research, 140: 43-48
Mutation Research 335: 15-20
cells
CANCER RESEARCH 44. 938-941.
human cells
Pharm World Sci. 20: 314-318
human, rats
Caries Research. 23:179-183
cells: human/animal
Sov Genet. 9:492-496
Environmental and Molecular Mutagenesis 21:309318
Solubility and surface properties of finely divided
hydroxyapatite
n/a
The phosphate of calcium. Part V. Revision of
the earlier space diagram
n/a
Maximizing calcium and phosphate content in
neonatal parenteral nutrition solutions using
organic calcium and phosphate salts
Effects of phosphate loading on 2,3diphosphoglycerate and maximal oxygen
uptake
Mutation Research, 139 193-198
Caries Res. 17 (1): 119-135
Journal of Research of then Nation Bureau of
Standards A. Physics and Chemistry. 77A. 1: 149155
Journal of the Chemistry. 2949-2955
n/a
Journal of Parenteral and Enteral Nutrition. 34(5): 542545
human
Medicine and Science in Sprots and Exercise. 18(3):
263-266
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
16th April 2012 - page 1-68
Organism tested
Source [journal name]
Sub ID
CAS Nr.
phosphoric acid
48
7664-38-2
Inco
1966
Corrosion resistance of nickel-containing alloys
in phosphoric acid
n/a
Corrosion Engieneering Bulletin. 4. 1-40
phosphoric acid
48
7664-38-2
Craig BD
1990
Handbook of Corrosion Data
n/a
n/a
sodium dihydrogenorthophosphate
(MSP)
2
7558-80-7
Duguid JB
1938
The primary lesion in phophate nephritis
rat
Journal of Pathology and Bacteriology. 43(2): 321326
phosphoric acid
48
7664-38-2
Ebling HF & Scheil MA
1951
A standard laboratory corrosion test for metals
in phosphoric acid service
n/a
Transactions of the ASME. 975-987
7664-38-2
Guenbour A, Hajji MA, Jallouli EM
and Bachir AB
2006
Study of corrosion–erosion behaviour of
stainless alloys in industrial phosphoric acid
medium
n/a
Applied Surface Science. 253: 2362-2366
phosphoric acid
potassium
dihydrogenorthophosphate,
dipotassium
hydrogenorthophosphate
tricalcium bis(orthophosphate) (ßTCP)
48
12, 13
7778-77-0
23
7758-87-4
Goldsmith RS, Jowsey J, Dube WJ,
Riggs BL, Arnaud CD & Kelly PJ
1976
Gregory TM, Moreno EC, Patel JM
& Brown WE
1974
phosphoric acid
tricalcium bis(orthophosphate) (ßTCP), calcium
hydrogenorthophosphate (DCP)
48
7664-38-2
Groves ND, Eisenbrown CM &
Sharfstein LR
1960
23, 22
7758.87-4
Holt LE, Lamer VK & Chown HB
calcium hydrogenorthophosphate
(DCP), hydroxyapatite
22, 24
7757-93-9
Hydroxyapatite (HAP)
24
phosphoric acid
48
Effects of phosphorus supplementation on
serum parathyroid hormone and bone
morphology in osteoporosis
Solubility of β-Ca3(PO4)2 in the system Ca(OH)2H3PO4-H2O at 5, 15, 25 and 37°C
human
n/a
Journal of clinical Endocrinology and Metabolism.
43(3): 523-532
Journal of Research of the National Bureau of
standards. A. Physics and Chemistry. 78A(6):
1925
Corrosion of metals by weak acids under heat
transfer conditions
n/a
Studies in calcification. 1. the solubility product
of secondary and tertiary calcium phosphate
under various conditions
n/a
Journal of Biological Chemistry: 64: 509-1925
Ishikawa K & Eanes ED
1993
The hydrolysis of anhydrous dicalcium
phosphate in hydroxyapatite
n/a
Journal of Dental Research. 72(2): 474-480
1306-06-5
Levinskas GJ & Neuman WF
1954
The solubility of bone mineral. I solubility
studies of synthetic hydroxylapatite.
n/a
Journal of chemistry. C. 59. 164-169
7664-38-2
Multi Alloy
n/a
Lab corrosion data for stainless steel.
n/a
Multi-alloy
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Corrosion - National association of corrosion
engineers. Vol 17. 173-176
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Object [title of the article]
Organism tested
Source [journal name]
Maurer JK, Cheng MC, Boysen BG
& Anderson RL
1990
Two-year carcinogenicity study of sodium
fluoride in rats
rat
Journal of the National Cancer Institute. 82(13): 11181126
7757-93-9
MCDowell H, Brown WE & Sutter
JR
1971
n/a
Inorganic Chemistry. 10(8):1638-1643
24
1306-06-5
Misra DN
1982
Solubility of calcium hydrogen phosphate. Ionpair formation.
Adsorption on and surface chemistry of
hydroxyapatite
n/a
textbook: Plenum Press
22, 23
7757-93-9
Monma H
1980
Preparation of octacalcium phosphate by the
hydrolysis of α- tricalcium phosphate
n/a
Journal of Materials Science.15:2428-2434
1966
Solubility of CaHPO4.2H2O and the formation
of ion pairs in the system Ca(OH)2-H3PO4-H20
at 37.5°C
n/a
Sub ID
CAS Nr.
sodium fluoride
n/a
n/a
calcium hydrogenorthophosphate
(DCP)
22
hydroxyapatite
calcim hydrogenorthophosphate,
tricalcium phosphate
Study
Year
Authors
16th April 2012 - page 1-69
Journal of Research of the National Bureau of
Standards - A. Physics and Chemistry. 70(A),6: 545553
Journal of Research of the National Bureau of
Standards - A. Physics and Chemistry. 72(A),6: 545554
calcium hydrogenorthophosphate
22
7757-93-9
Moreno EC, Gregory TM & Brown
WE
hydroxyapatite
24
1306-06-5
Moreno EC, Gregory TM & Brown
WE
1968
Preparation and solubility of hydroxyapatite
phosphoric acid
48
7664-38-2
Morgan AR
1959
Corrosion of types 316 and 317 Stainless steel
by 75% and 85% phosphoric acid
n/a
corrosion - national association of corrosion
engineers. Vol 15: 351-354
phosphate'
n/a
n/a
Nordin EC
Phosphorus
calcium hydrogenorthophosphate
22
7757-93-9
Patel PR, gregory TM & Brown WM 1974
n/a
Journal of Food and Nutrition. 45:3. 61-75
Journal of Research of the National Bureau of
Standards. A -Physics and Chemistry. 78(A).6: 675682
hydroxyapatite
24
1306-06-5
Pearce EIF
n/a
Journal of Dental Research. 67(7): 1056-1058
1988
Solubility of CaHPO4.2H2O in the quaternary
system Ca(OH)2-H3PO4-NaCl-H2O at 25°C
Letters to the editor: On the dissolution of
hydroxyapatite in acids
n/a
n/a
disodium hydrogenorthophosphate
3
7558-79-4
Prinzivalli M & Ceccarelli S
1999
sodium d-fructose-1,6-diphosphate vs. sodium
monohydrogenphosphate in total parenteral
nutrition: a comparative in vitro assessment of
calcium/phosphate compatibility
n/a
phosphoric acid
48
7664-38-2
Renshaw WG & Lula RA
1956
The corrosion properties of chrominum-nickelmanganese austenitic stainless steels
n/a
hydroxyapatite
24
1306-06-5
Saleeb FZ & De Bruyn PL
1972
Surface properties of alkaline earth apatites
n/a
Proceedings - American Society for testing and
Materials. 52: 866
Journal of Electroanalytical Chemistry and Interfacial
Electrochemistry. 37: 99 - 118
tricalcium bis(orthophosphate)
23
7758.87-4
Sanderson PH
1958
Functional Aspects of Renal Calcification in
Rats
rat
Clinical Science. 18:67-79
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Journal of parenteral and Enteral Nutrition. 23(6): 235242
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
octacalcium phosphate
n/a
n/a
Shyu LJ, Perez L, Zawacki SJ,
Heughebaert JC & Nancollas GH
1983
inorganic phosphate
n/a
n/a
Takeda E, Taketani Y, Sawada N,
Sato T & Yamamoto H
2004
phosphate'
n/a
n/a
hydroxyapatite
24
1306-06-5
Tenenhouse HS, Martel J, Rubin J
& Harvey N
1994
Verbeek RMH, Steyaer H, Thun HP
& Verbeek F
1980
phosphoric acid
48
7664-38-2
Warren D
1960
hydroxyapatite
24
1306-06-5
Wier D R, Chien SH & Black CA
1971
hydroxyapatite
24
1306-06-5
Wu MS, Higuchi WI, Fox JL &
Friendman M
1967
phosphoric acid
48
7664-38-2
Yaro AS, Wael RK & Khadom AA
2010
disodium fluorophosphate (SFP)
47
10163-15-2
Beinlich AD, Brun LRM, Rigalli A &
Puche RC
2003
disodium fluorophosphate (SFP)
47
10163-15-2
disodium fluorophosphate (SFP)
47
10163-15-2
Trautner K & Einwag J
1989
Van Asten P, Duursma, Glerum JH,
FFT Ververs, Van Rijn HJM & Van
Dijk A
1996
disodium fluorophosphate (SFP)
47
10163-15-2
Villa A, Carrasco G, Valenzuela A &
Garrido A
1992
glutamine monofluorophosphate
n/a
n/a
disodium fluorophosphate (SFP)
47
10163-15-2
phosphoric acid
48
7664-38-2
Warneke G & Setnikar I
1993
Elmore KL, Hatfield JD, Dunn RL &
Jones AD
1965
phosphoric acid
48
7664-38-2
Kreysa G and Shutze M
Warneke G, Setnikar I
1993
Object [title of the article]
16th April 2012 - page 1-70
Organism tested
The solubility of octacalcium phosphate at 37
°C in the system Ca(OH)2-H3PO4-KNO3-H2O n/a
Source [journal name]
Journal of Dental Research . 62: 398-400
The regulation and function of phosphate in the
human body
n/a
Effect of phosphate supplementation on the
expression of the mutant phenotype in murine xlinked hypophosphatemic rickets.
mice
Bone. 15(6): 677-683
Solubility of synthetic calcium hydroxyapatites
Faraday discussions. 1(76): 209-219
n/a
Biofactors 21. 345-355
Corrosion and weldability studies on chromiummanganese austenitic stainless steels
n/a
corrosion - National Association of Corrosion
Engineers. 16: 101-112
Solubility of hydroxyapatite
Kinetics and mechanism of hydroxyapatite
crystal dissolution in weak acid buffers using
the rotating disk method.
n/a
Soil Science. 111(2): 107 - 112
n/a
Journal of Dental Researc. 55(3): 496-505
n/a
Journal of the University of Chemical Technology and
Metallurgy. 45(4): 443-448
rat
ArzneimForschDrugRes. 53(8):584-589
human
Journal of Dental Research. 68: 72-77
human
Wur J Clinical Pharmacol. 50: 321-326
rat
Research Communications in Clinical Pathology and
Pharmacology. 77(3): 367-373
human
ArzneimForschDrugRes. 43(I).5:584-588
human
Arzneim-Forsch/Drug res. 43(I).5: 590-595
n/a
The journal of physical chemistry . 69(10): 3520-3525
n/a
Handbook. ISBN: 3-527-31119-X
Reaction kinetics of corrosion of mild steel in
phosphoric acid
Intestinal absorption of disodium
monofluorophosphate in the rat as affected by
concurrent administration of calcium.
Influence of milk and food on fluoride
bioavailability from NaF and Na2FPO3 in man.
Absolute bioavailability of fluoride from disodium
monofluorophosphate and enteric-coated
sodium fluoride tablets
The effect of calcium on disodium
monofluorophosphate absorption from the
gastrointestinal tract of the rat
Biavailability and pharmacokinetics of fluoride
from two glutamine monofluorophosphate
preparations
Effects of meal on the pharmacokinetics of
fluoride from oral monofluorophosphate
dissociation of phosphoric acid solutions at 25
°C
Corrosion Handbook. Corrosive agents and
their interaction with materials. Volume 3.
hypochlorites, phosphoric acid.
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
sodium tetraborate and boric acid
Study
Year
Authors
Sub ID
CAS Nr.
n/a
n/a
Soucek D, Dickenson A and Koch
BT
2011
mixture: monosodium phosphate
and disodium phosphate
2,3
n/a
Brunelli SM
2009
sodium phosphate' - likely to be a
mixture of MSP and DSP
2,3?
n/a
Seol DC, Hong SN, Kim JH, Sung
IK, Park HS, Lee Jh and Shim CS
2010
Juluir R, Eckhart G and Imperiale
TF
16th April 2012 - page 1-71
Object [title of the article]
Organism tested
Source [journal name]
Acute and chronic toxicity of boron to a variety
of fresh water organisms
various
Environmental Toxicology and Chemistry, Vol. 30,
No. 8, pp. 1906–1914,
human
American Journal of Kidney Diseases, Vol 53, No 3
(March), 2009: pp 448-456
human
World Journal of Gastroenterology (2010) April 28;
16(16): 2010-2016
human
BMC Gastroenterology 2011, 11:38
human
J Am Soc Nephrol 16: 3389–3396, 2005
Mice
Arteriosclerosis, Thrombosis and vascular biology.
2011:31
rats/mice
NTIS PB234866
rats/mice
NTIS PB22381
rats/mice
FDABF-GRAS-075
algae
Chemosphere 85 (2011) 1026–1032
Association Between Oral Sodium Phosphate
Bowel Preparations and Kidney Injury: A
Systematic Review and Meta-analysis
Change in renal function after sodium
phosphate preparation for screening
colonoscopy
sodium phosphate' - likely to be a
mixture of MSP and DSP
2,3?
n/a
sodium phosphate' - likely to be a
mixture of MSP and DSP
2,3?
n/a
monocalcium phosphate, dicalcium
phosphate
21, 22
7758-23-8
Markowitz GS, Stokes MB,
Radhakrishnan J,and D’Agati VD
Ellam T, Wilkie M, Chamerlain J,
Crossman D, Eastell R, Francis S
and Chico TJA
monocalcium phosphate (MCP)
21
7758-23-8
Morgareidge K
1974
SODIUM ACID PYROPHOSPHATE
5
7758-16-9
Morgareidge K
1973
sodium tripolyphosphate
0
7758-29-4
Morgareidge K
1973
monopotassium phosphate
12
7778-77-0
Naddy RB, Tapp K, Rehner AB,
Pillard DA, Schrage L
2011
Polyethylene glycol vs. sodium phosphate for
bowel preparation: A treatment arm
metaanalysis of randomized controlled trials
Acute Phosphate Nephropathy following Oral
Sodium Phosphate Bowel Purgative: An
Underrecognized Cause of Chronic Renal
Failure
Dietary Phosphate Modulates Atherogenesis
and Insulin Resistance in Apolipoprotein E
Knockout Mice
Teratologic evaluation of FDA 71-81,
(monocalcium phosphate; monohydrate) in
mice, rats and rabbits
Teratologic evaluation of FDA 71-61, (sodium
acid pyrophosphate)
Teratologic evaluation of FDA 71-46 (sodium
tripolyphosphate, anhydrous)
Identifying the cause of toxicity in an algal whole
effluent toxicity study –
An unanticipated toxicant
various inorganic polypjosphates
n/a
n/a
Tatyana V. Kulakovskaya, Vladimir
M. Vagabov, Igor S. Kulaev
2010
Inorganic polyphosphate in industry, agriculture
and medicine: modern state and outlook
n/a
Process biochemistry
Purification and Characterization of Highly
Active and Stable Polyphosphatase from
Saccharomyces cerevisiae Cell Envelope
YEAST VOL. 9: 127-1 39
polyphosphates
n/a
2005
2001
Inorganic linear polyphosphate
Andreeva NA & Okorokov
1993
Leyhausen G, Lorenz B, Zhu H,
Geurtsen W, Bohnensack R, Muller
WEG & Schroder HC
1998
Inorganic polymeric
phosphate/polyphosphate
Muller WEG, Wang X, Diehl-Seifert
B, Kropf K, Schlossmacher U,
Lieberwirth I, Glasser G, Weins M &
Schroder HC
2011
n/a
n/a
2011
n/a
yeast (S.cerevisiae)
Inorganic Polyphosphate in Human Osteoblastlike Cells
n/a - cells
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 13, Number 5, 1998
Inorganic polymeric phosphate/polyphosphate
as an inducer of alkaline phosphatase and a
modulator of intracellular Ca2+ level in
osteoblasts (SaOS-2 cells) in vitro
Acta Biomaterialia 7 (2011) 2661–2671
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
inorganic polyphosphate
n/a
n/a
Y. Hacchou, T. Uematsu, O. Ueda,
Y. Usui, S. Uematsu, M. Takahashi,
T. Uchihashi, Y. Kawazoe, T. Shiba,
S. Kurihara, M. Yamaoka and K.
Furusawa
2007
inorganic polyphosphates
n/a
n/a
Lorenz B & Schroder HC
n/a
Lubov Ryazanova, Nadeschda
Andreeva, Tatiana Kulakovskaya,
Airat Valiakhmetov, Valerii Yashin,
Vladimir Vagabov, Igor Kulaev
n/a
Y. Kawazoe, T. Shiba, R.
Nakamura, A. Mizuno, K. Tsutsumi,
T. Uematsu, M. Yamaoka, M.
Shindoh and T. Kohgo
2004
Matsuzaki H, Katsumata S, Uehara
M, Uehara M, Nakamura K &Suzuki
K
2002
inorganic polyphosphate
inorganic polyphosphate
n/a
n/a
Object [title of the article]
16th April 2012 - page 1-72
Organism tested
Source [journal name]
Inorganic Polyphosphate: a Possible Stimulant
of Bone Formation
n/a
J DENT RES 2007 86: 893
2001
Mammalian intestinal alkaline phosphatase acts
as highly active exopolyphosphatase
n/a
Biochimica et Biophysica Acta 1547 (2001) 254-261
2011
The early stage of polyphosphate accumulation
in Saccharomyces cerevisiae: comparative
study by extraction and DAPI staining
yeast (S.cerevisiae)
Advances in Bioscience and Biotechnology, 2011, 2,
293-297
Induction of Calcification in MC3T3-E1 Cells by
Inorganic Polyphosphate
n/a
J DENT RES 2004 83: 613
Sex differences in kidney mineral
concentrations and urinary albumin excretion in
rats given high-phosphorus feed.
rat
Catalytic ability of alkaline phosphatase to
promote P-O-P bond hydrolyses of inorganic
diphosphate and triphosphate
n/a
potassium
dihydrogenorthophosphate
12
7778-77-0
inorganic diphosphate, triphosphate
n/a
n/a
Yoza N, Onoue S & Kuwahara Y
phosphate
n/a
n/a
Kaneko H, Shimada A & Hirayama
K
Short-term algal toxicity test based on
phosphate uptake
algae
Water Research 38 (2004) 2173–2177
Atuah L & Hodson ME
2011
A comparison of the relative toxicity of bone
meal and other P sources used as remedial
treatments to the earthworm Eisenia fetida
earthworm
Pedobiologia. Article in press,
2010
Evaluation of inherent toxicology and
biocompatibility of magnesium phosphate
bone cement
n/a
Colloids and Surfaces B: Biointerfaces 76 : 496–504
2001
Assessment of Metal Availability in Smelter Soil
Using Earthworms and Chemical Extractions
earthworm
J. Environ. Qual. 30:1231–1237
2010
Evaluation of the adverse effects of two
commonly used fertilizers, DAP and urea,
on motility and orientation of the green flagellate
Euglena gracilis
Euglena gracilis
Environmental and Experimental Botany 74: 140–
150
potassium
dihydrogenorthophosphate
12
7778-77-0
Magnesium phosphate cement
n/a
n/a
Yu Y, Wang J, Liu C, Zhang B,
Chen H, Guo H, Zhong G, Qu W,
Jiang S & Huang H
rock phosphate
n/a
n/a
Condor JM, Lanno RP & Basta NT
diammonium phosphate
19
7783-28-0
Azizullah A, Nasir A, Richter P,
Lebert M & Hader DP
1997
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Biosci. Biotechnol. Biochem 66(8): 1737-1739
Chemical society of Japan. Chemistry letters. 491492
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
inorganic phosphate' in vivo
bone ash
Sub ID
CAS Nr.
n/a
n/a
24
68439-86-1
Authors
Study
Year
Kuro-o M
Davis NA, Hodson ME & Black S
16th April 2012 - page 1-73
Object [title of the article]
Organism tested
Source [journal name]
2010
A potential link between phosphate and
aging—Lessons from Klotho-deficient mice
mice
Mechanisms of Ageing and Development 131 :
270–275
2002
Changes in toxicity and bioavailability of lead in
contaminated soils to the earthworm Eisenia
fetida (Savigny 1826) after bone meal
amendments to the soil.
earthworm
Triple Super Phosphate
n/a
n/a
Gouider M, Feki M & Sayadi S
phosphate
n/a
n/a
Ohnishi M, Kato S & Razzaque MS 2011
Bioassay and use in irrigation of untreated and
treated wastewaters from phosphate fertilizer
industry
Genetic induction of phosphate toxicity
significantly reduces the survival
of hypercholesterolemic obese mice
Maenpaa KA, Kukkonen JVK &
Lydy MJ
Remediation of Heavy Metal-Contaminated
Soils Using Phosphorus: Evaluation
of Bioavailability Using an Earthworm Bioassay earthworm
potassium
dihydrogenorthophosphate
phosphoric acid
phosphoric acid, dicalcium phosphate
dicalcium phosphate
phosphoric acid, monocalcium
phosphate monohydrate,
dipotassium phosphate
Manganese oxide, Manganese
sulphate, Trimanganese tetraoxide,
Manganese phosphate (hureaulite)
(MMangP)
12
7778-77-0
2010
2002
Arch. Environ. Contam. Toxicol. 43, 389–398
1995
Poultry Science. 74: 1820-1830
Application of pharmacokinetic data to the risk
assessment of inhaled manganese
NeuroToxicity, 27: 752-764
7664-38-2
Ibrahim S, Fisher C, El Alaily H,
Soliman H and Anwar A
22
7757-93-9
18718-07-5
Biochemical and Biophysical Research
Communications xxx (2011) xxx–xxx Article in press.
An Evaluation of Various Response Criteria in
Assessing Biological Availability of Phosphorus
for Broilers
chicks
48, 22
34
mice
Poultry Science. 74: 813-820
7664-38-2
7664-38-2
Ecotoxicology and Environmental Safety 73:932–938
1995
48
48, 21, 22
plants
Effect of dietary phosphoric acid
supplementation on acid-base balance and
mineral and bone metabolism in adult cats
cat
Improvement of the nutritional quality of
Egyptian and Sudanese sorghum grains by the
addition of phosphates
chicks
Bioavailability of phosphorus in various
phosphate sources using body weight and toe
ash as response criteria
chicks
Fettman MJ, Coble JM, Hamar DW,
Norrdin RW
1992
Potter LM, Potchanakorn M,
Ravindran V and Kornegay ET
Ravindran V, Kornegay ET, Potter
LM, Ogunabameru BO, Welten
MK, Wilson JH and Potchanakorn
M
Environmental Toxicology and Chemistry, Vol. 21,
No. 12,:2685–2691
1988
Dorman DC, Struve MF, Clewell HJ
III and Anderson ME
2006
Rat, human
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Am J Vet Res, 53(11): 2125-2135
British Poultry Science. 29: 721-728
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Manganese phosphate (hureaulite)
(MMangP)
Manganese phosphate (hureaulite)
(MMangP)
Study
Year
Authors
34
34
16th April 2012 - page 1-74
Object [title of the article]
Organism tested
Source [journal name]
18718-07-5
Dorman DC, Struve MF, Marshall
MW, Parkinson CU, James RA, and
Wong BA
2006
Tissue manganese concentrations in young
male rhesus monkeys following subchronic
manganese sulfate inhalation
Monkey
Toxicological Sciences, 92(1): 201-210
18718-07-5
Dorman DC, McManus BE,
Marshall MW, James RA and
Struve MF
2004
Old age and gender influence the
pharmacokinetics of inhaled manganese sulfate
and manganese phosphate in rats
Rat
Toxicology and Applied Pharmacology, 197: 113-124
2000
Contributions on crystal structures and thermal
behaviour of anhydrous phosphates XXIX Preparation and structure determination of
SrMn2(PO4)2 and Β'-Mn3(PO4)2
N/A
Zeitschrift für anorganische und allgemeine Chemie,
626(12): 2557-2562
CAS Nr.
No IP substances: SrMn2(PO4)2
and Β'-Mn3(PO4)2
N/A
N/A
Manganese phosphate (hureaulite)
(MMangP) Mn5(HPO4)2(PO4)2.4H2O
34
18718-07-5
El-Bali B, Boukhari A, Glaum R,
Gerk M and Maaß K
Phosphate hydrogénophosphate hydrate de
Gerault Y, Riou A and Cudennec Y 1987
manganèse
N/A
Acta Cryst. C43: 1829-1830
No IP substances: Mn (unspecified)
N/A
N/A
Gwiazda R, Lucchini R and Smith D 2007
Various phosphates
Manganese phosphate (hureaulite)
(MMangP) Mn5(HPO4)2(PO4)2.4H2O
N/A
N/A
Huminicki DMC and Hawthorne FC 2002
Adequacy and consistency of animal studies to
evaluate the neurotoxicity of chronic low-level
manganese exposure in humans
Rodent, primate
The Crystal Chemistry of the Phosphate
Minerals
N/A
34
18718-07-5
Unknown
2005?
Huréaulite Mn52+(HPO4)2(PO4)2.4H2O
N/A
Handbook of Mineralogy
Manganese phosphate (hureaulite)
(MMangP) (Mn,Fe)5(PO4)2(HPO4)2.4H2O
34
18718-07-5
?
http://www.mindat.org/min-1952.html [accessed
21 Oct 2011]
33
14154-09-7
Hureaulite
A novel modification of manganese
orthophosphate Mn3(PO4)2
N/A
Manganese orthophosphate
Unknown
Massa W, Yakubovich OV and
Dimitrova OV
N/A
Solid State Sciences, 7: 950-956
2005
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Journal of Toxicology and Environmental Health, Part
A, 70(7)
Reviews in Mineralogy and Geochemistry, 48: 123253
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Hureaulite Mn52+(H2O)4[PO3(OH)]2[PO4]2
Manganese phosphate (hureaulite)
Mn5(PO4)2(PO3(OH))2.4H2O,
Sub ID
CAS Nr.
34
18718-07-5
Authors
Study
Year
Moore PB and Takahuru A
1973
Hureaulite, Mn52+(H2O)4[PO3(OH)]2[PO4]2:
Its atomic arrangement
N/A
American Mineralogist, 58: 302-307
2004
Manganese distribution in the brain and
neurobehavioural changes following inhalation
exposure of rats to three chemical forms of
manganese
NeuroToxicology, 25: 433-441
Environmental Toxicology and Pharmacology, 23:
286-296
Canadian Journal of Plant Science, 79: 125-128
Normandin L, Beaupré, Salehi F, St34
16th April 2012 - page 1-75
Object [title of the article]
Organism tested
Source [journal name]
18718-07-5
Pierre A, Kennedy G, Mergler D,
Butterworth RF, Philippe S and Zayed J
Sistrunk SC, Ross MK and Filipov
NM
2007
Direct effects of manganese compounds on
dopamine and its metabolite Dopac: an in vitro
study
Rat
Eaton LJ, Hoyle J and King A
1999
Effects of deicing salt on lowbush blueberry
flowering and yield
Ecotoxicology, 20: 88-96
Nature and Science, 7(11): 28-42
Manganese phosphate (hureaulite)
Mn5(PO4)2(PO3(OH))2.4H2O
34
18718-07-5
No IP substances investigated - NaCl
N/A
N/A
Rat
N/A
No IP substances investigated - NaCl
and KCl
N/A
N/A
Freitas EC and Rocha O
2011
Acute and chronic effects of sodium and
potassium on the tropical freshwater cladoceran
Pseudosida ramosa
Crustacean
No IP substances investigated - NaCl
and sea water
N/A
N/A
El-Deeb Ghazy MM, Habashy MM,
Kossa FI and Mohammady EY
2009
Effects of salinity on survival, growth and
reproduction of the water flea, Daphnia magna
Crustacean
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
No IP substances investigated - NaCl
N/A
N/A
Martínez-Jerónimo F and MartínezJerónimo L
No IP substances investigated - NaCl
N/A
N/A
Nielsen DL, Brock MA, Rees GN
and Baldwin DS
16th April 2012 - page 1-76
Object [title of the article]
Organism tested
Source [journal name]
Crustacean
Ecotoxicology and Environmental Safety, 67: 411-416
N/A
Australian Journal of Botany, 51: 655-665
2007
Chronic effect of NaCl salinity on a freshwater
strain of Daphnia magna Straus (Crustacea:
Cladocera): A demographic study
2003
Effects of increasing salinity on freshwater
ecosystems in Australia
Bull Environ Contam Toxicol, 66: 379-385
Arch Hydrobiol, 120(2): 185-196
No IP substances investigated - KCl and
potassium acetate (KC2H3O2)
N/A
N/A
Utz LRP and Bohrer MBC
2001
Acute and chronic toxicity of potassium chloride
(KCl) and potassium acetate (KC2H3O2) to
Daphnia similis and Ceriodaphnia dubia
(Crustacea; Cladocera)
Crustacea
No IP substances investigated - NaCl
and CaCO3
N/A
N/A
Cowgill UM and Milazzo DP
1990
The sensitivity of two cladocerans to water
quality variables: salinity and hardness
N/A
Dodds WK, Carney E and Angelo
RT
2006
Determining ecoregional reference conditons for
nutrients, secchi depth and chlorophyll a in
Kansas lakes and reservoirs
Phosphorus (unspecified)
N/A
Crustacea
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Sub ID
CAS Nr.
Study
Year
Object [title of the article]
1999
Nutrients in European ecosystems
16th April 2012 - page 1-77
Organism tested
Source [journal name]
Phosphate (unspecified),
orthophosphate, polyphosphate,
phosphorus (unspecified), P2O5
N/A
N/A
Crouzet P, Nixon S, Rees Y, Parr
W, Laffon L, Bøgestrand J,
Kristensen P, Lallana C, Izzo G,
Bokn T, Bak J, Lack TJ and
Thyssen N (Ed)
Phosphorus (unspecified),
orthophosphate
N/A
N/A
European Environment Agency
?
Nitrogen and phosphorus in rivers
Indicator fact sheet (WEU02)
Phosphorus (unspecified)
N/A
N/A
Filippelli GM
2008
The global phosphorus cycle: past present and
future
Elements, 4:89-95
Calcium, magnesium, sodium,
potassium, ammonium, sulfate,
nitrate, chloride, orthophosphate,
hydrogen, bicarbonate, hydroxide
N/A
N/A
National Atmospheric Deposition
Program
1991
Quality assurance report NADP/NTN deposition
monitoring
Various (Ca2+, Mg2+, Na+, K+, Cl-,
SO42-, HCO3-, SiO2)
N/A
N/A
Meybeck M
2003
Global occurrence of major elements in rivers
Treatise on Geochemistry : Surface and Ground
Water, Weathering, and Soils, Elsevier Ltd, ISBN: 008-044340-0 pages 207–223
Various (S, Na, K, N, P)
N/A
N/A
Meybeck M and Helmer R
1989
The quality of rivers: from pristine stage to
global pollution
Palaeogeography, Palaeoclimatology, Palaeoecology
(Global and Planetary Change Section), 75: 283-309
Aguilar F, Charrondiere UR,
Dusemund B et al
2009
Scientific Opinion of the Panel on Food
Additives and Nutrient Sources added to Food
on a request from the European Commission
on Ferrous phosphate added for nutritional
purposes to food supplements.
The EFSA Journal, 951: 1-13
Solheim AL (Ed)
2005
Reference conditions of European Lakes
REBECCA Project (draft paper)
Ferrous phospate
27
10045-86-0
Phosphorus
N/A
N/A
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Study
Year
Authors
Sub ID
CAS Nr.
Object [title of the article]
16th April 2012 - page 1-78
Organism tested
Source [journal name]
Originally published in Guidelines for drinking water
quality, 2nd ed, Vol 2, Health criteria and other
supporting information, World Health Organisation,
Geneva, 1996
No IP substances investigated CaC03
N/A
N/A
World Health Organisation
2003
Hardness in drinking water; Background
document for development of WHO guidelines
for drinking-water quality
No IP substances investigated
N/A
N/A
Beck GR Jr, Zerler B and Moran E
2000
Phosphate is a specific signal for induction of
osteopontin gene expression
PNAS, 97(15): 8352-8357
N/A
Camalier CE, Young MR, Bobe G,
Perella CM, Colburn NH and Beck
GR Jr
2010
Elevated phosphate activates N-ras and
promotes cell transformation and skin
tumorigenesis
Cancer Prev, 3(3): 359-370
2010
Low dietary inorganic phosphate stimulates
lung tumorigenesis through altering protein
translation and cell cycle in K-rasLA1 mice
Nutrition and Cancer, 62(4): 525-532
Phosphate (unspecified)
N/A
Phosphate (unspecified)
N/A
N/A
Xu C-X , Jin H, Lim H-T, Ha Y-C,
Chae C-H, An G-H, Lee K-H and
Cho M-H
Phosphate (unspecified)
N/A
N/A
Jin H et al
2009
High dietary inorganic phosphate increases
lung tumorigenesis and alters Akt signaling
Am J Respir Crit Care Med, 179: 59-68
Phosphate (unspecified)
N/A
N/A
Kapur S
2000
A Medical Hypothesis: Phosphorus Balance
and Prostate Cancer
Cancer Investigation, 18(7): 664-669
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Phosphate (unspecified)
Study
Year
Authors
N/A
CAS Nr.
Object [title of the article]
16th April 2012 - page 1-79
Organism tested
Source [journal name]
N/A
Giovannucci E, Rimm EB, Wolk A,
Ascherio A, Stampfer MJ, Colditz
GA and Willett WC
1998
Calcium and fructose intake in relation to risk of
prostate cancer
Cancer Research, 58: 442-447
Stoichiometry and the New Biology: The Future
Is Now
PLoS Biology www.plosbiology.org , 5(7): 1403-1405
and Biological Stoichiometry in Human Cancer, PLoS
ONE, www.plosone.org, 10: 1-7
Phosphate (unspecified)
N/A
N/A
Elser J
2007
and
2010
Phosphate (unspecified)
N/A
N/A
Borrell B
2010
Elemental shortage
The Scientist, 24(11): 46
2005
A combined proteome and microarray
investigation of inorganic phosphate-induced
pre-osteoblast cells
Mol Cell Proteomics, 4: 1284-1296
Monobasic sodium phosphate
(NaH2PO4) and dibasic sodium
phosphate (Na2HPO4)
7558-80-7, 755879-4
Conrads KA, Yi M, Simpson KA et
al
2, 3
Phosphate (unspecified)
N/A
N/A
Elser JJ, Nagy JD and Kuang Y
2003
Biological stoichiometry: an ecological
perspective on tumor dynamics
BioScience, 53(11): 1112-1120
Phosphorus
N/A
N/A
Elser JJ, Kyle MM, Smith MS and
Nagy JD
2007
Biological stoichiometry in human cancer
PLoS ONE 2(10): e1028.
doi:10.1371/journal.pone.0001028
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Phosphate (unspecified)
Study
Year
Authors
N/A
CAS Nr.
N/A
Engström W and Zetterberg A
Object [title of the article]
16th April 2012 - page 1-80
Organism tested
Source [journal name]
1983
Phosphate and the regulation of DNA
replication in normal and virus transformed 3T3
cells
Biochem J, 214: 695-702
http://www.slideshare.net/changezkn/summary5553163 [accessed 29 March 2012]
Phosphate (unspecified)
N/A
N/A
Anon
2009
Statement of the International Food Additives
Council and the European Chemical Industry
Council on Jin et al "High Dietrary Inorganic
Phosphate Increases Lung Tumorigenesis and
Alters Akt Signaling"
Phosphate (unspecified)
N/A
N/A
Laws JO and Strickland LH
1962
The rate of changes of inorganic phosphate
content of Ehrlich Ascites-Tumour cells
Biochem J, 83: 84-91
2004
Opinion of the scientific panel on dietetic
products, nutrition and allergies on a request
from the commission related to the tolerable
upper intake level of iron
The EFSA Journal, 125, 1-34
No IP substances investigated
N/A
N/A
EFSA
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
CAS Nr.
SALP acidic and SALP basic
43
7785-88-8
Manganese (unspecified)
N/A
N/A
Phosphoric acid
48
7664-38-2
16th April 2012 - page 1-81
Authors
Study
Year
EFSA
2011
Statement on the evaluation of a new study
related to the bioavailability of aluminium in food
Aschner M, Erikson KM and
Dorman DC
2005
Manganese dosimetry: species differences and
implications for neurotoxicity
Sweet DV
19851986
58663. Phosphoric Acid
Critical Reviews in Toxicology, 35:1-32
National Institute for Occupational Safety and Health,
Registry of Toxic Effects of Chemical Substances,
Volume 4
Andreoli SP, Bergstein JM,
Sherrard DJ
1984
Aluminium intoxication from aluminiumcontaining phosphate binders in children with
azotemia not undergoing dialysis
New England Journal of Medicine, 310(17): 1079-84
2009
A 90-day subchronic toxicity study of betacalcium pyrophosphate in rat
Drug and Chemical Toxicology, 32(3): 277-282
Phosphoric acid
Documentation of the Threshold Limit Values and
Biological Exposure Indices, 7th Ed
Aluminium hydroxide
N/A
N/A
β-calcium pyrophosphate
26
232-221-5
Lee JH, Chang B-S, Ryu HS and
Lee C-K
Phosphoric acid
48
7664-38-2
American Conference of
Governmental Industrial Hygienists 2001
Object [title of the article]
Organism tested
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Source [journal name]
The EFSA Journal, 9(5): 2157
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Authors
Study
Year
Object [title of the article]
16th April 2012 - page 1-82
Organism tested
Source [journal name]
Sub ID
CAS Nr.
Al(OH)3, AlPO4, Al
40
7784-30-7
Berthon G and Daydé SD
1992
Why aluminium phosphate is less toxic than
aluminium hydroxide
Journal of the American College of Nutrition, 11(3):
340-348
No IP substances investigated
N/A
N/A
Vaezy A and Budson DC
1978
Phalangeal metastases from bronchogenic
carcinoma
JAMA, 239(3): 225-226
1990
Aluminium speciation studies in biological
fluids. Part 3. Quantitative investigation of
aluminium-phosphate complexes and
assessment of their potential significance in vivo
Journal of Inorganic Biochemistry, 38: 241-259
1833
Researches on the arsenates, phosphates and
modifications of phosphoric acid
Alembic Club, London Agents Simpkin, Marshall,
Hamilton, Kent & Co Ltd (1904)
2003
Research Report No. 70: Effects of fire
retardant on soils of heathland in Victoria
Department of Sustainability and Environment, PO
Box 500, East Melbourne, Victoria 3002 (ISBN 1
74106 903 3)
1943
Comparison of molasses-alfalfa silage and
phosphoric acid-alfalfa silage as feeds for the
milking cow
NJ Agricultural Experiment Station Bulletin 704
1944
Comparison of molasses-oat silage and
phosphoric acid-oat silage as feeds for the
milking cow
NJ Agricultural Experiment Station Bulletin 708
1989
Effects of fire retardant on water quality
USDA Forest Service Gen Tech Rep PSW-109
Orthophosphoric acid
Orthophosphoric acid,
pyrophosphoric acid,
metaphosphoric acid
monoammonium phosphate,
diammonium phosphate, calcium
phosphate
Phosphoric acid
Phosphoric acid
Ammonium phosphate,
diammonium phosphate
48
45, 48, 50
18, 19
48
48
18, 19
7664-38-2
Daydé S, Filella M and Berthon G
245-490-9, 233782-9, 231-6332, 219-574-0 Graham T
233-330-0, 231987-8
Hopmans P and Bickford R
7664-38-2
7664-38-2
King WA
King WA
233-330-0, 231987-8
Norris LA and Webb WL
Publicly available published studies of which the IP Consortium has purchased a copyright copy
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Fused tricalcium phosphate, raw
rock phosphate (P2O5)
Phosphorus (unspecified),
ammonium phosphate,
aminomethylphosphonic acid
Phosphates and superphosphates,
phosphorus and compounds,
phosphoric acid
No IP substances investigated
Phosphorus and phosphorus
compounds, organophosphate
insecticides
Phosphoric acid
Study
Year
Authors
Object [title of the article]
16th April 2012 - page 1-83
Organism tested
Source [journal name]
Sub ID
CAS Nr.
23
231-840-8
Mather RE, Pratt AD and Holdaway
CW
1949
Fused tricalcium phosphate as a low-fluorine
phosphorus supplement for dairy cattle
J Dairy Science, 32(3): 228-235
18
233-330-0
Norris LA, Lorz HW and Gregory
SV
1983
Influence of forest rangeland management on
anadromous fish habitat in western North
America: Forest chemicals
USDA Forest Service General Technical Report PSW149
Various
Various
Parmeggiani L (Ed)
1983
Volume 2: L-Z
Encyclopaedia of occupational health and safety third
(revised) edition (ISBN 92-2-103291-4)
N/A
N/A
Penner GE
1980
Acid ingestion: toxicology and treatment
Ann Emerg Med, 9(7): 374-379
Sullivan JB and Krieger GR (Eds)
1992
Hazardous materials toxicology: clinical
principles of environmental health
Williams & Wilkins, 428 East Preston Street,
Baltimore, Maryland 21202, USA (ISBN 0-683-080253)
Anon
1957
Hygienic guide series: phosphoric acid
American Industrial Hygiene Association quarterly,
18(2): 175-176
The effect of feeding sodium fluoride and rock
phosphate on bone development in swine: a
preliminary report
J Anim Sci: 29-33
Various
Various
48
7664-38-2
Rock phosphate
N/A
N/A
Bethke RM, Kick CH, Edgington BH
and Wilder OH
1930
Phosphate (unspecified)
Phosphorus, phosphoric acid,
phosphorus pentoxide, phosphorus
chlorides
N/A
N/A
Ritz E, Hahn K, Ketteler M,
Kuhlmann MK and Mann J
2012
48
7785-88-8
US Office of Health and
Environmental Assessment
1990
Phosphate additives in food—a health risk
Summary review of health effects associated
with elemental inorganic phosphorus
compounds
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Deutsches Ärzteblatt International, 109(4):49-55
EPA/600/8-89-072
IP Studies list - PART ** I **
Inorganic Phosphate (IP) Consortium
Substance
Sub ID
Phosphoric acid and various other
phosphorus containing substances
Various
Phosphoric acid
Triple super phosphate, rock
phosphate, monocalcium
phosphate, tricalcium phosphate
dicalcium phosphate, tricalcium
phosphate
Raw rock phosphate
Pyrophosphoric acid, sodium
pyrophosphate
Study
Year
Authors
CAS Nr.
Object [title of the article]
16th April 2012 - page 1-84
Organism tested
Source [journal name]
48
7785-88-8
Forbes EB and Keith MH
1914
Ohio Agricultural Experiment Station Technical
Series, Bulletin No 5: Phosphorus compounds
in animal metabolism
Various
Various
Gilbert A and Posternak S
1903
La medication phosphoree envisagee au point
de vue des echanges nutritifs de l'organisme
L'Oeuvre med-chir 36: 48
48
7785-88-8
US EPA
2011
Phosphoric acid; CASRN 7664-38-2
Integrated Risk Information System (IRIS)
21, 23
22, 23
N/A
5, 50
7758-23-8,
65996-95-4,
Ownby DR, Galvan KA and Lydy
7758-87-4
MJ
231-826-1, 775887-4
Poty P-L
N/A
Reed OE and Huffman CF
7758-16-9, 246609-3
Withers WA and Ray BJ
1928
Lead and zinc bioavailability to Eisenia fetida
after phosphorus amendment to repository soils
Phosphates bicalcique et tricalcique dans
l'alimentation des animaux domestiques
Dairy cattle need phosphorus in ration: lack of
this element causes depraved appetites of
animals
1913
Studies in cotton seed meal intoxication I:
Pyrophosphoric acid
2005
1932
Publicly available published studies of which the IP Consortium has purchased a copyright copy
Wooster, Ohio, USA
Environmental Poluution, 136: 315-321
Ecole Nationale Veterinaire D'Alfort
Michigan Agricultural Experiment Station Quarterly
Bulletin, 10(4): 152-156 [ISBN 00976911]
Journal of Biological Chemistry, XIV(2): 53-58
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
copper-II-hydroxyphosphate
sub ID
CAS Nr.
38
12158-74-6
Endpoint
Authors
Study
Year
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Bernd Aldorf,
BTA
2004
Object
Acute toxicity Daphnia
copper-II-hydroxyphosphate
sodium metaphosphate insoluble
HO3PNa
38
12158-74-6
8.5.1 Acute toxicity, oral [vi 6.5.1]
Mr D. Kuhn, Dr
Francois
Richeux
2004
Acute oral toxicity Rat
11
10361-03-2
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Dr. H. Lebertz
1999
Acute toxicity Daphnia
diammonium phosphate
19
7783-28-0
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
1999
Acute toxicity Daphnia
copper (II)-pyrophosphate
37
10102-90-6
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Dr. H. Lebertz
Bernd Aldorf,
BTA
2004
Acute toxicity Daphnia
copper (II)-pyrophosphate
37
10102-90-6
8.5.1 Acute toxicity, oral [vi 6.5.1]
Mr D. Kuhn, Dr
Francois
Richeux
2004
Acute oral toxicity Rat
boron phosphate
46
13308-51-5
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Dr. H. Lebertz
1999
Acute toxicity Daphnia
ammonium polyphosphate
20
14728-39-3
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
1999
Acute toxicity Daphnia
STPP
0
7758-29-4
8.2.1 In vivo eye irritation [vi 6.2.1]
Dr. H. Lebertz
Becker J., Parke
G. St. E.
1975
Effects on eye mucosa - albinos rabbits
8.1.1 In vivo skin irritation [vi 6.1.1]
Becker J., Parke
G. St. E
1975
Skin irritation - albinos rabbits
1990
Acute toxicity - Daphnia
1986
1989
1997
Preliminary eye irritation - rabbits
Skin irritation - rabbits
Acute oral toxicity - Rats
1989
Acute inhalation toxicity - Rats
STPP
0
7758-29-4
STPP
0
7758-29-4
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
STPP
STPP
STPP
0
0
0
7758-29-4
7758-29-4
7758-29-4
8.2.1 In vivo eye irritation [vi 6.2.1]
8.1.1 In vivo skin irritation [vi 6.1.1]
8.5.1 Acute toxicity, oral [vi 6.5.1]
Vaishnav D.D.,
Yurk J.J., Ives,
Wade B.A.
W. Barta, T.
Cascieri,
Freeman C
Watt B
STPP
0
7758-29-4
8.5.2 Acute toxicity, inhalation [vi 6.5.2]
Jackson G.C.,
Hardy C.J.,
Chanter D.O.
Tetrapotassium pyrophosphate
15
7320-34-5
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Vaishnav D.D.,
Yurk J.J., Ives,
Wade B.A.
1991
Acute toxicity Daphnia
Sodium hexametaphosphate
10
10124-56-8
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Yurk J.J.
1993
Acute toxicity Daphnia
Dipotassium phosphate
13
7758-11-4
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1987
Skin irritation and toxicity rabbits
Dipotassium phosphate
13
7758-11-4
8.5.3 Acute toxicity, dermal [vi 6.5.3]
Freeman C
1987
Skin irritation and toxicity rabbits
Tri-potassium phosphate
14
7778-53-2
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1987
Skin irritation and toxicity rabbits
Tri-potassium phosphate
14
7778-53-2
8.5.3 Acute toxicity, dermal [vi 6.5.3]
Freeman C
1987
Skin irritation and toxicity rabbits
Mono-sodium phosphate
2
7558-80-7
8.2.1 In vivo eye irritation [vi 6.2.1]
Freeman C
1987
Eye irritation rabbits
Sodium hexametaphosphate
10
10124-56-8
8.2.1 In vivo eye irritation [vi 6.2.1]
Freeman C
1986
Eye irritation rabbits
Mono-potassium phosphate
12
7778-77-0
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1990
Skin irritation rabbits
Mono-potassium phosphate
12
7778-77-0
8.2.1 In vivo eye irritation [vi 6.2.1]
Freeman C
1986
Eye irritation rabbits
Potassium tri-polyphosphate
16
13845-36-8
8.2.1 In vivo eye irritation [vi 6.2.1]
Freeman C
1987
Eye irritation rabbits
Dipotassium phosphate
13
7758-11-4
8.2.1 In vivo eye irritation [vi 6.2.1]
Freeman C
1987
Eye irritation rabbits
Tetrapotassium pyrophosphate
Di-sodium phosphate
15
3
7320-34-5
7558-79-4
8.2.1 In vivo eye irritation [vi 6.2.1]
8.2.1 In vivo eye irritation [vi 6.2.1]
Freeman C
Freeman C
1987
1987
Eye irritation rabbits
Eye irritation rabbits
Di-potassium phosphate
13
7758-11-4
8.5.1 Acute toxicity, oral [vi 6.5.1]
Freeman C
1987
Preliminary oral toxicity - Rats
Di-potassium phosphate
13
7758-11-4
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1987
Skin irritation and toxicity rabbits
Di-potassium phosphate
13
7758-11-4
8.5.3 Acute toxicity, dermal [vi 6.5.3]
Freeman C
1987
Skin irritation and toxicity rabbits
Tetra-potassium pyrophosphate
15
7320-34-5
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1988
Skin irritation rabbits
Tetra-potassium pyrophosphate
15
7320-34-5
8.5.3 Acute toxicity, dermal [vi 6.5.3]
Freeman C
1988
Skin toxicity rabbits
Tetra-sodium pyrophosphate
7
7722-88-5
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1988
Skin irritation rabbits
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-1
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
Endpoint
Authors
Study
Year
Object
Phosphoric acid
48
7664-38-2
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1989
Skin irritation rabbits
Mono-sodium phosphate
2
7558-80-7
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1990
Skin irritation rabbits
Potassium tri-polyphosphate
16
13845-36-8
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1990
Skin irritation rabbits
Sodium hexametaphosphate
10
10124-56-8
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1990
Skin irritation rabbits
Tricalcium phosphate
24
1306-06-5
8.1.1 In vivo skin irritation [vi 6.1.1]
Freeman C
1993
Skin irritation rabbits
Mono-sodium phosphate
2
7558-80-7
8.5.2 Acute toxicity, inhalation [vi 6.5.2]
Signorin J.
1993
Acute inhalation toxicity rats
Sodium Acid Pyrophosphate
5
7758-16-9
8.5.2 Acute toxicity, inhalation [vi 6.5.2]
Signorin J.
1993
Acute inhalation toxicity rats
Sodium hexametaphosphate
10
10124-56-8
8.5.2 Acute toxicity, inhalation [vi 6.5.2]
Signorin J.
1993
Acute inhalation toxicity rats
Tetrapotassium pyrophosphate
15
7320-34-5
8.5.2 Acute toxicity, inhalation [vi 6.5.2]
Signorin J.
1993
Acute inhalation toxicity rats
STPP
0
7758-29-4
8.1.1 In vivo skin irritation [vi 6.1.1]
Dr. Weigand M.
1966
“Natriumtripolyphosphat toxikologische
prüfung” - Skin and eye irritation - rats Translation 2002 by Roth T., Clariant.
STPP
0
7758-29-4
8.2.1 In vivo eye irritation [vi 6.2.1]
Dr. Weigand M.
1966
“Natriumtripolyphosphat toxikologische
prüfung” - Skin and eye irritation - rats Translation 2002 by Roth T., Clariant.
STPP
0
7758-29-4
Growth inhibition of algae [v 7.1.2 ]
Herschke B.,
Cellier
1985
"Ecotoxicilogie du tripolyphosphate …" Toxicity algae (fresh and sea water)
STPP
0
7758-29-4
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Dion M
1985
"Etude de la toxicité aquatique …" Acute toxicity daphnia and zebra fish
STPP
0
7758-29-4
9.1.3 Short term acute toxicity fish [v 7.1.3]
Dion M
1985
"Etude de la toxicité aquatique …" Acute toxicity daphnia and zebra fish
STPP
0
7758-29-4
8.1.1 In vivo skin irritation [vi 6.1.1]
Kamienski F. X.,
C.H. Bullock
1971
Acute oral (rat) and dermal toxicity, skin
and eye irritation (all rabbit)
STPP
0
7758-29-4
8.5.1 Acute toxicity, oral [vi 6.5.1]
Kamienski F. X.,
C.H. Bullock
1971
Acute oral (rat) and dermal toxicity, skin
and eye irritation (all rabbit)
STPP
0
7758-29-4
8.5.3 Acute toxicity, dermal route [vi 6.5.3]
Kamienski F. X.,
C.H. Bullock
1971
Acute oral (rat) and dermal toxicity, skin
and eye irritation (all rabbit)
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic toxicity, oral [vi 6.5.1]
Smith P.S.
1972
90 days subacute oral toxicity
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic toxicity, oral [vi 6.5.1]
Reyna M.S.
1973
90 days subacute oral toxicity
sodium aluminum phosphate
43
7785-88-8
8.6.1 Short-term repeated dose toxicity, oral
Smith P.S.
1972
30 days pilot study
sodium aluminum phosphate
43
7785-88-8
8.6.2 90-day repeated-dose toxicity
Mastalski K.
1972
90 days subacute oral toxicity
8.4 in vivo Mutagenicity
Newell G.W,
Jorgenson T.A.
Simon V.F.
1974
Host-mediated assay
8.4 In vitro Mutagenicity
Newell G.W,
Jorgenson T.A.
Simon V.F.
1974
in vitro microbial assay
8.4 in vivo Mutagenicity
Newell G.W,
Jorgenson T.A.
Simon V.F.
1974
dominant lethal test
8.4 in vivo Mutagenicity
Newell G.W,
Jorgenson T.A.
Simon V.F.
1974
mouse translocation test
sodium Acid Pyrophosphate
sodium Acid Pyrophosphate
sodium Acid Pyrophosphate
sodium Acid Pyrophosphate
5
5
5
5
7758-16-9
7758-16-9
7758-16-9
7758-16-9
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-2
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
Endpoint
Authors
sodium acid Pyrophosphate
5
7758-16-9
8.5.1 Acute toxicity, oral
Newell G.W,
Jorgenson T.A.
Simon V.F.
sodium Acid Pyrophosphate
5
7758-16-9
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
Study
Year
1974
1973
Object
Mutagenicity evaluation - precurser to
RDL and mouse translocation
sodium Acid Pyrophosphate
5
7758-16-9
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
sodium Acid Pyrophosphate
5
7758-16-9
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
sodium Acid Pyrophosphate
5
7758-16-9
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
mix
NA
8.5.1 Acute toxicity, oral [vi 6.5.1]
Younger F.M.
1965
deicer ID1352D
deicer ID1352D
mix
NA
8.5.3 Acute toxicity, dermal
Younger F.M.
1965
single oral dose
acute skin absorption minimal lethal
dose
deicer ID1352D
mix
NA
8.1.1 In vivo skin irritation [vi 6.1.1]
Younger F.M.
1965
Skin irritation - albinos rabbits
deicer ID1352D
PhosCheck202 (diammonium
phosphates mix)
PhosCheck202 (diammonium
phosphates mix)
PhosCheck202 (diammonium
phosphates mix)
PhosCheck202 (diammonium
phosphates mix)
mix
NA
8.2.1 In vivo eye irritation [vi 6.2.1]
Younger F.M.
1965
Eye irritation rabbits
19
7783-28-0
8.5.1 Acute toxicity, oral [vi 6.5.1]
Younger F.M.
1965
19
7783-28-0
8.5.3 Acute toxicity, dermal
Younger F.M.
1965
single oral dose
acute skin absorption minimal lethal
dose
19
7783-28-0
8.1.1 In vivo skin irritation [vi 6.1.1]
Younger F.M.
1965
Skin irritation - albinos rabbits
19
7783-28-0
8.2.1 In vivo eye irritation [vi 6.2.1]
Younger F.M.
1965
Eye irritation rabbits
diammonium phosphate
19
7783-28-0
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
diammonium phosphate
19
7783-28-0
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
diammonium phosphate
19
7783-28-0
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
diammonium phosphate
19
7783-28-0
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
monoammonium phosphate
18
7722-76-1
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
monoammonium phosphate
18
7722-76-1
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
monoammonium phosphate
18
7722-76-1
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
monoammonium phosphate
18
7722-76-1
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
trisodium phosphate
4
7601-54-9
8.1.1 In vivo skin irritation [vi 6.1.1]
Younger F.M.
1962
Skin irritation - albinos rabbits
trisodium phosphate
4
7601-54-9
8.2.1 In vivo eye irritation [vi 6.2.1]
Younger F.M.
1962
Eye irritation rabbits
trisodium phosphate
4
7601-54-9
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
trisodium phosphate
4
7601-54-9
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
trisodium phosphate
4
7601-54-9
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
trisodium phosphate
4
7601-54-9
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
trisodium phosphate
4
7601-54-9
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1977
trisodium phosphate
4
7601-54-9
8.5.3 Acute toxicity, dermal
Birch M.D.
1977
single oral dose
acute skin absorption minimal lethal
dose
trisodium phosphate
4
7601-54-9
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1977
Skin irritation - albinos rabbits
trisodium phosphate
4
7601-54-9
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1977
Eye irritation rabbits
disodium phosphate
3
7558-79-4
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1972
skin irritation
disodium phosphate
3
7558-79-4
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
disodium phosphate
3
7558-79-4
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
disodium phosphate
3
7558-79-4
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
disodium phosphate
3
7558-79-4
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
monosodium phosphate
2
7558-80-7
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
single oral dose
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-3
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
monosodium phosphate
2
7558-80-7
8.5.3 Acute toxicity, dermal
monosodium phosphate
2
7558-80-7
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
monosodium phosphate
2
7558-80-7
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
sodium trimetaphosphate
8
7785-84-4
8.5.1 Acute toxicity, oral [vi 6.5.1]
Younger F.M.
1961
single oral dose
sodium trimetaphosphate
8
7785-84-4
8.1.1 In vivo skin irritation [vi 6.1.1]
Younger F.M.
1961
Skin irritation - albinos rabbits
Birch M.D.
1973
Object
acute skin absorption minimal lethal
dose
sodium trimetaphosphate
8
7785-84-4
8.2.1 In vivo eye irritation [vi 6.2.1]
Younger F.M.
1961
Eye irritation rabbits
insoluble sodium metaphosphate
11
10361-03-2
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
insoluble sodium metaphosphate
11
10361-03-2
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
insoluble sodium metaphosphate
11
10361-03-2
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
insoluble sodium metaphosphate
11
10361-03-2
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
Skin irritation - albinos rabbits
tetrasodium pyrophosphate
7
7722-88-5
8.1.1 In vivo skin irritation [vi 6.1.1]
Younger F.M.
1962
tetrasodium pyrophosphate
7
7722-88-5
8.2.1 In vivo eye irritation [vi 6.2.1]
Younger F.M.
1962
Eye irritation rabbits
tetrasodium pyrophosphate
7
7722-88-5
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
tetrasodium pyrophosphate
7
7722-88-5
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
tetrasodium pyrophosphate
7
7722-88-5
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
tetrasodium pyrophosphate
monopotassium phosphate
7
12
7722-88-5
7778-77-0
8.2.1 In vivo eye irritation [vi 6.2.1]
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
Birch M.D.
1973
1973
monopotassium phosphate
12
7778-77-0
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
Eye irritation rabbits
single oral dose
acute skin absorption minimal lethal
dose
monopotassium phosphate
12
7778-77-0
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
monopotassium phosphate
12
7778-77-0
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
dipotassium phosphate
13
7758-11-4
8.2.1 In vivo eye irritation [vi 6.2.1]
Blaszcak D.L.
1986
Eye irritation rabbits
dipotassium phosphate
13
7758-11-4
Acute oral toxicity
Blaszcak D.L.
1986
Acute oral toxicity
dipotassium phosphate
13
7758-11-4
Acute dermal toxicity
Blaszcak D.L.
1986
Acute dermal toxicity
Tripotassium phosphate
14
7778-53-2
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1976
Tripotassium phosphate
14
7778-53-2
8.5.3 Acute toxicity, dermal
Birch M.D.
1976
single oral dose
acute skin absorption minimal lethal
dose
Tripotassium phosphate
14
7778-53-2
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1976
Skin irritation - albinos rabbits
Tripotassium phosphate
14
7778-53-2
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1976
Eye irritation rabbits
tetrapotassium phosphate
15
7320-34-5
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
tetrapotassium phosphate
15
7320-34-5
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
tetrapotassium phosphate
15
7320-34-5
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
tetrapotassium phosphate
15
7320-34-5
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
tetra-potassium pyrophosphate
15
7320-34-5
8.5.1 Acute toxicity, oral [vi 6.5.1]
Younger F.M.
1961
single oral dose
tetra-potassium pyrophosphate
15
7320-34-5
8.1.1 In vivo skin irritation [vi 6.1.1]
Younger F.M.
1961
Skin irritation - albinos rabbits
tetra-potassium pyrophosphate
15
7320-34-5
8.2.1 In vivo eye irritation [vi 6.2.1]
Younger F.M.
1961
Eye irritation rabbits
monocalcium Phosphate
21
7758-23-8
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
single oral dose
acute skin absorption minimal lethal
dose
monocalcium Phosphate
21
7758-23-8
8.5.3 Acute toxicity, dermal
Birch M.D.
1973
monocalcium Phosphate
21
7758-23-8
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1973
Skin irritation - albinos rabbits
monocalcium Phosphate
21
7758-23-8
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
dicalcium phosphate
22
7757-93-9
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1974
dicalcium phosphate
22
7757-93-9
8.5.3 Acute toxicity, dermal
Birch M.D.
1974
single oral dose
acute skin absorption minimal lethal
dose
dicalcium phosphate
22
7757-93-9
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
1974
Skin irritation - albinos rabbits
dicalcium phosphate
22
7757-93-9
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1974
Eye irritation rabbits
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-4
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
dicalcium phosphate
22
7757-93-9
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
dicalcium phosphate
dicalcium phosphate
22
22
7757-93-9
7757-93-9
8.5.3 Acute toxicity, dermal
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
Birch M.D.
1973
1973
single oral dose
acute skin absorption minimal lethal
dose
Skin irritation - albinos rabbits
dicalcium phosphate
22
7757-93-9
8.2.1 In vivo eye irritation [vi 6.2.1]
Birch M.D.
1973
Eye irritation rabbits
calcium pyrophosphate
26
7790-76-3
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1973
calcium pyrophosphate
calcium pyrophosphate
26
26
7790-76-3
7790-76-3
8.5.3 Acute toxicity, dermal
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
Birch M.D.
1973
1973
single oral dose
acute skin absorption minimal lethal
dose
Skin irritation - albinos rabbits
calcium pyrophosphate
trimagnesium phosphate
26
30
7790-76-3
7757-87-1
8.2.1 In vivo eye irritation [vi 6.2.1]
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
Birch M.D.
1973
1975
trimagnesium phosphate
trimagnesium phosphate
30
30
7757-87-1
7757-87-1
8.5.3 Acute toxicity, dermal
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
Birch M.D.
1975
1975
Eye irritation rabbits
single oral dose
acute skin absorption minimal lethal
dose
Skin irritation - albinos rabbits
trimagnesium phosphate
STPP
30
0
7757-87-1
7758-29-4
8.2.1 In vivo eye irritation [vi 6.2.1]
8.1.1 In vivo skin irritation [vi 6.1.1]
Birch M.D.
Younger F.M.
1975
1962
Eye irritation rabbits
Skin irritation - albinos rabbits
STPP
0
7758-29-4
8.2.1 In vivo eye irritation [vi 6.2.1]
Younger F.M.
1962
Eye irritation rabbits
STPP
0
7758-29-4
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1976
acute oral toxicity – Rats
STPP
0
7758-29-4
8.5.1 Acute toxicity, oral [vi 6.5.1]
Birch M.D.
1976
acute oral toxicity – Rats
etude des especes phosphatees en
sortie de machine a laver
etude des especes phosphatees en
sortie de machine a laver
etude des especes phosphatees en
sortie de machine a laver
Monosodium orthophosphate
2
7558-80-7
hydrolysis
Gaillot J.C.
1985
Sodium pyrophosphate
5
7758-46-9
hydrolysis
Gaillot J.C.
1985
0
7758-29-4
hydrolysis
Gaillot J.C.
1985
8.6.1 Short term repeated doses
Hodge C.H.
Sodium tripolyphosphate hexaydrate
orthophosphate
NA
1956
pilot toxicity test
sodium metaphosphate
10
10124-56-8
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
sodium tripolyphosphate
0
7758-29-4
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
sodium trimetaphosphate
8
7785-84-4
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
sodium tetrametaphosphate
NA
20758-95-6
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
orthophosphate
NA
0
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
sodium metaphosphate
10
10124-56-8
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
sodium tripolyphosphate
0
7758-29-4
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
sodium trimetaphosphate
8
7785-84-4
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
NA
20758-95-6
8.6.1 Short term repeated doses
Hodge C.H.
1956
pilot toxicity test
sodium tripolyphosphate
0
7758-29-4
8.6.3 Long term oral tox
Hodge C.H.
1959
chronic oral toxicity studies in rats
sodium trimetaphosphate
8
7785-84-4
8.6.3 Long term oral tox
Hodge C.H.
1960
chronic oral toxicity studies in rats
sodium trimetaphosphate
8
7785-84-4
Acute tox - other (IP route)
Hodge C.H.
1960
chronic oral toxicity studies in rats
sodium hexametaphosphate
10
10124-56-8
8.6.3 Long term oral tox
Hodge C.H.
1960
chronic oral toxicity studies in rats
sodium hexametaphosphate
10
10124-56-8
8.5.1. Acute toxicity oral
Hodge C.H.
1960
Acute oral toxicity
sodium tetrametaphosphate
sodium tripolyphosphate
0
7758-29-4
8.7.3 Reproductive toxicity multigeneration
Hodge C.H.
1959
chronic oral toxicity studies in rats
sodium hexametaphosphate
10
10124-56-8
8.7.3 Reproductive toxicity multigeneration
Hodge C.H.
1960
chronic oral toxicity studies in rats
sodium trimetaphosphate
8
7785-84-4
8.7.3 Reproductive toxicity multigeneration
Hodge C.H.
1960
chronic oral toxicity studies in rats
sodium tripolyphosphate
0
7758-29-4
8.9.1 Carcinogenicity
Hodge C.H.
1959
chronic oral toxicity studies in rats
sodium hexametaphosphate
10
10124-56-8
8.9.1 Carcinogenicity
Hodge C.H.
1960
chronic oral toxicity studies in rats
sodium trimetaphosphate
8
7785-84-4
8.9.1 Carcinogenicity
Hodge C.H.
1960
chronic oral toxicity studies in rats
Eutrophication
De Madariaga
2007
Europhication risk assessment
Inhibition of the mobility of Daphnia
magna
phosphates
sodium tripolyphosphate
NA
0
7758-29-4
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Pandard
2004
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-5
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
sodium tripolyphosphate
0
7758-29-4
sodium tripolyphosphate
0
7758-29-4
sodium tripolyphosphate
0
sodium tripolyphosphate
Endpoint
Authors
Study
Year
Object
2004
Inhibition of the mobility of Ceriodaphnia
dubia
2008
local lymph node assay
7758-29-4
9.1.1 Short term acute toxicity daphnia [v 7.1.1]
Pandard
8.3.2. Skin sensitisation in vivo test (LLNA first choice
method)
Bradshaw J.
Woolley A.j.,
7.4. relative density
Woolley S.M.
2008
determination of relative density
0
7758-29-4
8.3.2 Skin Sensitisation (Buehler method)
P&G
1999
Buehler study
dicalcium phosphate
22
7757-93-9
8.5.1 acute toxicity, oral
Kamienski FX
1970
toxicity studies on dicalcium phosphate
dicalcium phosphate
22
7757-93-9
8.5.1 subacute toxicity(14 day), oral
Kamienski FX
1970
toxicity studies on dicalcium phosphate
1987
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic toxicity, oral
Pettersen JC,
Zwicker GM and
Hackett DS
trisodium phosphate (dodecahydrate)
4
7601-54-9
8.5.1 Acute toxicity, oral
Pontrepka RF
1981
trisodium phosphate (dodecahydrate)
4
7601-54-9
8.5.3 Acute toxicity, dermal
Pontrepka RF
1981
trisodium phosphate (dodecahydrate)
4
7601-54-9
8.1.1 skin irritation in vivo
Pontrepka RF
1981
trisodium phosphate (dodecahydrate)
4
7601-54-9
8.2.1 eye irritation in vivo
Pontrepka RF
1981
26-week subchronic toxicity study with
kasal in dogs
trisodium phosphate, crystalline.
Toxicity
trisodium phosphate, crystalline.
Toxicity
trisodium phosphate, crystalline.
Toxicity
trisodium phosphate, crystalline.
Toxicity
trisodium phosphate (dodecahydrate)
4
7601-54-9
9.1.3 short-term toxicity testing on fish
Potrepka RF
1981
trisodium phosphate, crystalline.
Toxicity
8.5.1 Acute toxicity, oral
?
1968
8.5.1 Acute toxicity, oral
Bullock CH
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
1970
?
Acute oral toxicity of levn-lite in male
rats
1971
Toxicology lab report
1971
Toxicology lab report
by-product of phosphoric acid'
n/a
sodium aluminum phosphate
43
Phosphoric acid
48
Phosphoric acid
48
unknown
7785-88-8
7664-38-2
7664-38-3
8.2.1 eye irritation in vivo
8.1.1 skin irritation in vivo
Phosphoric acid
48
7664-38-2
8.1.1 skin irritation in vivo
Super phosphoric acid
N/A
?
8.1.1 skin irritation in vivo
diammonium phosphate
19
7783-28-0
8.1.1 skin irritation in vivo
diammonium phosphate
19
7783-28-0
8.5.1 Acute toxicity, oral
monoaluminium phosphate
39
13530-50-2
8.1.1 skin irritation in vivo
monoaluminium phosphate
39
13530-50-2
8.5.1 Acute toxicity, oral
monoammonium phosphate
18
7722-76-1
8.1.1 skin irritation in vivo
monocalcium phosphate
21
7758-23-8
8.5.1 Acute toxicity, oral
monocalcium phosphate
21
7758-23-8
8.1.1 skin irritation in vivo
1971
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-6
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
Endpoint
monomagnesium phosphate (solution)
31
13092-66-5
8.5.1 Acute toxicity, oral
monomagnesium phosphate (solution)
31
13092-66-5
8.1.1 skin irritation in vivo
monopotassium phosphate
12
7778-77-0
8.1.1 skin irritation in vivo
Potassium tri-polyphosphate
16
13845-36-8
8.1.1 skin irritation in vivo
sodium aluminum phosphate
43
7785-88-8
8.1.1 skin irritation in vivo
Tetrapotassium pyrophosphate
15
7320-34-5
8.1.1 skin irritation in vivo
tetrasodium pyrophosphate
7
7722-88-5
8.1.1 skin irritation in vivo
Authors
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Study
Year
1972
Object
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
trisodium phosphate
4
7601-54-9
8.1.1 skin irritation in vivo
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Kamienski FX.
Bullock CH and
Heil JF
Henderson L and
Joiner RL
Henderson L and
Joiner RL
1974
Toxicology lab report
aluminum metaphosphate
42
13776-88-0
8.1.1 skin irritation in vivo
Joiner RL
1975
Toxicology lab report
aluminum metaphosphate
42
13776-88-0
8.5.1 Acute toxicity, oral
Joiner RL
1975
Toxicology lab report
monoaluminium phosphate
39
13530-50-2
8.5.1 Acute oral toxicity
Joiner RL
1975
Toxicology lab report
tetrasodium pyrophosphate
7
7722-88-5
8.5.1 Acute toxicity, oral
dipotassium phosphate
13
7785-11-4
8.5.1 Acute toxicity, oral
iron orthophosphate
27
10045-86-0
8.5.1 Acute toxicity, oral
monosodium phosphate
2
7558-80-7
8.5.1 Acute toxicity, oral
sodium Acid Pyrophosphate
5
7758-16-9
8.5.1 Acute toxicity, oral
sodium hexametaphosphate
9
68915-31-1
8.5.1 Acute toxicity, oral
Tricalcium phosphate
24
7758-87-4
8.5.1 Acute toxicity, oral
polyphosphoric acid
49
8017-16-1
8.1.1 skin irritation in vivo
trisodium phosphate - dodecahydrate
4
7601-54-9
8.1.1 skin irritation in vivo
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1973
Toxicology lab report
1974
Toxicology lab report
monoaluminium phosphate
39
13530-50-2
8.1.1 skin irritation in vivo
Joiner RL
1975
Toxicology lab report
monomagnesium phosphate (solution)
31
13092-66-5
8.5.1 Acute oral toxicity
Joiner RL
1975
Toxicology lab report
monomagnesium phosphate (solution)
31
13092-66-5
8.1.1 skin irritation in vivo
Joiner RL
1975
Toxicology lab report
tetrasodium pyrophosphate
7
7722-88-5
8.5.1 Acute toxicity, oral
Jones B
1979
Toxicology lab report
tetrasodium pyrophosphate
7
7722-88-5
8.5.3 Acute toxicity, dermal
Jones B
1979
Toxicology lab report
tetrasodium pyrophosphate
7
7722-88-5
8.1.1 skin irritation in vivo
Jones B
1979
Toxicology lab report
tetrasodium pyrophosphate
7
7722-88-5
8.2.1 eye irritation in vivo
Jones B
1979
Toxicology lab report
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-7
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
sodium aluminum phosphate
43
7785-88-8
8.6.2 Sub-chronic toxicity, 6 months
Katz AC
1981
A 6-moth sub-chronic dietary study with
LEVAIR in Beagle dogs
sodium aluminum phosphate (KASAL)
43
7785-88-8
8.5.1 Acute toxicity, oral
Jones BJ
1980
Toxicology lab report
sodium aluminum phosphate (KASAL)
43
7785-88-8
8.5.3 Acute toxicity, dermal
Jones BJ
1980
Toxicology lab report
sodium aluminum phosphate (KASAL)
43
7785-88-8
8.1.1 skin irritation in vivo
Jones BJ
1980
Toxicology lab report
sodium aluminum phosphate (KASAL)
43
7785-88-8
8.2.1 eye irritation in vivo
Jones BJ
1980
Toxicology lab report
Tricalcium phosphate
24
1306-06-5
8.5.1 Acute toxicity, oral
Foster TL
1985
Toxicology lab report
Tricalcium phosphate
24
1306-06-5
8.5.3 Acute toxicity, dermal
Foster TL
1985
Toxicology lab report
Tricalcium phosphate
24
1306-06-5
8.1.1 skin irritation in vivo
Foster TL
1985
Toxicology lab report
Tricalcium phosphate
24
1306-06-5
8.2.1 eye irritation in vivo
Foster TL
1985
sodium aluminum phosphate
43
7785-88-8
8.6.1 short-term repeated dose, oral, 28-day
Sprague GL
1986
Toxicology lab report
4-week dietary comparative toxicity
study with KASAL in rats
trisodium phosphate (dodecahydrate)
4
7601-54-9
8.1.1 skin irritation in vivo
Glaza SM
1992
Primary dermal irritation study of
trisodium phosphate dodecahydrate
(saturated solution at 10°C) in rabbits
trisodium phosphate (dodecahydrate)
4
7601-54-9
8.1.1 skin irritation in vivo
Glaza SM
1992
Primary dermal irritation study of
trisodium phosphate dodecahydrate
(saturated solution at 22°C) in rabbits
trisodium phosphate (dodecahydrate)
4
7601-54-9
8.2.1 eye irritation in vivo
Glaza SM
1992
Phosphoric acid
48
7664-38-2
8.5.1 Acute toxicity, oral
?
1975
Phosphoric acid
48
7664-38-2
8.5.1 Acute toxicity, oral
?
1975
Primary eye irritation study of trisodium
phosphate dodecahydrate (saturated
solution at 10°C) in rabbits
Acute oral toxicity in rats. Compound:
MCTR-1-75
Acute oral toxicity in rats. Compound:
MCTR-1-75
1975
the acute dermal toxicity study of
MCTR-1-75. New Zealand Albino
rabbits
1975
The effects of MCTR-1-75 on the eye
mucosa of new zealand abino rabbits
Phosphoric acid
48
7664-38-2
8.5.3 Acute toxicity, dermal
Becker J and
Parke G
Phosphoric acid
48
7664-38-2
8.2.1 eye irritation, in vivo
Becker J and
Parke G
Phosphoric acid
48
7664-38-2
8.1.1 skin irritation in vivo
monaluminium phosphate
39
13530-50-2
8.5.1 Acute toxicity, oral
Becker J and
Parke G
Terrell Y and
Parke G
Tripotassium phosphate
14
7778-53-2
8.5.1 Acute toxicity, oral
Tripotassium phosphate
14
7778-53-2
8.5.1 Acute toxicity, oral
Terrell Y and
Parke G
Terrell Y and
Parke G
Tripotassium phosphate (liquid)
14
7778-53-2
8.4.1 In vitro mutagenicicty in bacteria
Jagannath DR
1975
1975
A primary dermal irritation study of
MCTR-1-75 on abraded and
nonabraded skin of New Zealand albino
rabbits
Acute oral toxicity in rats. Compound:
MCTR-2-75
1975
Acute oral toxicity in rats. Compound:
MCTR-7-75
Acute oral toxicity in rats. Compound:
MCTR-7-75
1977
Mutagenicity evaluation of MCTR-258
1975
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-8
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
tetrapotassium pyrophosphate (liquid)
15
7320-34-5
magnesium phosphate (liquid)
31
Magnesium phosphate (solution)
Endpoint
Authors
Study
Year
Object
8.5.3 Acute toxicity, dermal
Imlay P and
Parke G
1977
Report on the acute dermal toxicity of
rabbits
10392-66-5
8.1.1 skin irritation in vivo
Nitka S
1979
DOT skin corrosion in rabbits
31
10392-66-5
8.5.1 Acute toxicity, oral
?
1981
The acute oral toxicity of magnesium
phosphate solution in albino rats
Magnesium phosphate (solution)
31
10392-66-5
8.5.3 Acute toxicity, dermal
?
1981
The acute dermal toxicity of magnesium
phosphate solution in albino rabbits
Magnesium phosphate (solution)
31
10392-66-5
8.2.1 eye irritation in vivo
?
1981
Primary eye irritation of magnesium
phosphate solution in albino rabbits
Magnesium phosphate (solution)
31
10392-66-5
8.1.1 Skin irritation in vivo
1981
tetrapotassium pyrophosphate
15
7320-34-5
8.5.1 Acute toxicity, oral
tetrapotassium pyrophosphate
15
7320-34-5
8.5.1 Acute toxicity, oral
?
Terrel Y and
Parke G
Terrel Y and
Parke G
tetrapotassium pyrophosphate (liquid)
15
7320-34-5
8.4.1 Mutagenicity in bacteria
Tripotassium phosphate (liquid)
14
7778-53-2
8.5.3 Acute toxicity, dermal
dipotassium phosphate
13
7758--11-4
8.5.1 Acute toxicity, oral
dipotassium phosphate
13
7758--11-4
8.5.1 Acute toxicity, oral
1975
1975
1977
Skin irritation of magnesium phosphate
solution after a single application to
albino rabbits
Acute oral toxicity in rats. Compound:
MCTR-6-75
Acute oral toxicity in rats. Compound:
MCTR-6-75
dipotassium phosphate
13
7758--11-4
8.5.3 Acute toxicity, dermal
Brusick DJ
Imlay P and
Parke G
Terrel Y and
Parke G
Terrel Y and
Parke G
Imlay P and
Parke G
1977
Mutagenicity evaluation of MCTR-257
Report on the acute dermal toxicity of
rabbits
Acute oral toxicity in rats. Compound:
TDR-41-75
Acute oral toxicity in rats. Compound:
MCTR-4-75
Report on the acute dermal toxicity of
rabbits
dipotassium phosphate
13
7758--11-4
8.4.1 Mutagenicity in bacteria
Jagannath DR
1977
Mutagenicity evaluation of MCTR-256
monocalcium phosphate
21
7758-23-8
8.5.1 Acute toxicity, oral
Sorenson S
1985
Acute toxicity test battery for
monocalcium phosphate anhydrous
monocalcium phosphate
21
7758-23-8
8.5.3 Acute toxicity, dermal
Sorenson S
1985
Acute toxicity test battery for
monocalcium phosphate anhydrous
monocalcium phosphate
21
7758-23-8
8.1.1 Skin irritation in vivo
Sorenson S
1985
Acute toxicity test battery for
monocalcium phosphate anhydrous
monocalcium phosphate
21
7758-23-8
8.2.1 eye irritation in vivo
Sorenson S
1985
Acute toxicity test battery for
monocalcium phosphate anhydrous
sodium hypophosphite
monoaluminium phosphate (50%
solution)
monoaluminium phosphate (50%
solution)
monoaluminium phosphate (50%
solution)
monoaluminium phosphate (50%
solution)
N/A
N/A
N/A
Heil J
1974
N/A
39
13530-50-2
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
39
13530-50-2
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
39
13530-50-2
8.2.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
39
13530-50-2
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
1977
1975
1975
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-9
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
tripotassium phosphate
14
7778-53-2
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
tripotassium phosphate
14
7778-53-2
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
tripotassium phosphate
14
7778-53-2
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
tripotassium phosphate
14
7778-53-2
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
aluminium metaphosphate
42
13776-88-0
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
aluminium metaphosphate
42
13776-88-0
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
aluminium metaphosphate
42
13776-88-0
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
aluminium metaphosphate
42
13776-88-0
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
sodium iron pyrophosphate
N/A
10045-87-1
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
sodium iron pyrophosphate
N/A
10045-87-1
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
sodium iron pyrophosphate
N/A
10045-87-1
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
sodium iron pyrophosphate
N/A
10045-87-1
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
sodium trimetaphosphate
8
7785-84-4
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
sodium trimetaphosphate
8
7785-84-4
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
sodium trimetaphosphate
8
7785-84-4
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
sodium trimetaphosphate
8
7785-84-4
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
potassium polymetaphosphate
N/A
?
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
potassium polymetaphosphate
N/A
?
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
potassium polymetaphosphate
N/A
?
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
potassium polymetaphosphate
N/A
?
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
tetrapotassium pyrophosphate
15
7320-34-5
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
tetrapotassium pyrophosphate
15
7320-34-5
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
tetrapotassium pyrophosphate
15
7320-34-5
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
tetrapotassium pyrophosphate
15
7320-34-5
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
potassium tripolyphosphate
16
13845-36-8
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
potassium tripolyphosphate
16
13845-36-8
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
potassium tripolyphosphate
16
13845-36-8
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-10
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
potassium tripolyphosphate
16
13845-36-8
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
monopotassium phosphate
12
7778-77-0
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
monopotassium phosphate
12
7778-77-0
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
monopotassium phosphate
12
7778-77-0
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
monopotassium phosphate
12
7778-77-0
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
Magnesium phosphate (solution)
31
13092-66-5
8.5.1 Acute toxicity, oral
Kamienski FX
1971
Toxicology lab report
Magnesium phosphate (solution)
31
13092-66-5
8.5.3 Acute toxicity, dermal
Kamienski FX
1971
Toxicology lab report
Magnesium phosphate (solution)
31
13092-66-5
8.1.1 Skin irritation in vivo
Kamienski FX
1971
Toxicology lab report
Magnesium phosphate (solution)
31
13092-66-5
8.2.1 eye irritation in vivo
Kamienski FX
1971
Toxicology lab report
sodium aluminium phosphate
43
7785-88-8
8.2.1 eye irritation in vivo
sodium hexametaphosphate
10
68915-31-1
8.1.1 skin irritation in vivo
dicalcium phosphate
22
7757-93-9
8.1.1 skin irritation in vivo
dipotassium phosphate
13
7758--11-4
8.1.1 skin irritation in vivo
disodium phosphate
3
7558-79-4
8.1.1 skin irritation in vivo
ferric orthophosphate
27
10045-86-0
8.1.1 skin irritation in vivo
insoluble sodium metaphosphate
11
10361-03-2
8.1.1 skin irritation in vivo
monosodium phosphate
2
7558-80-7
8.1.1 skin irritation in vivo
sodium trimetaphosphate
8
7785-84-4
8.1.1 skin irritation in vivo
tricalcium phosphate
24
1306-06-5
8.1.1 skin irritation in vivo
trimagnesium phosphate
30
7757-87-1
8.1.1 skin irritation in vivo
monocalcium phosphate
21
7758-23-8
8.1.1 Skin irritation in vivo
n/a
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Bullock CH and
Kamienski FX
Henderson L and
Joiner RL
monocalcium phosphate
21
7758-23-8
8.8.1 Toxicokinetics
Killenger JM
n/a
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1972
Toxicology lab report
1974
Toxicology lab report
1986
Calcium phosphates, calcium sulfate
and calcium carbonate bioavailability
and disposition in rats.
dicalcium phosphate
22
7757-93-9
8.8.1 Toxicokinetics
Killenger JM
1986
Calcium phosphates, calcium sulfate
and calcium carbonate bioavailability
and disposition in rats.
tricalcium phosphate
24
1306-06-5
8.8.1 Toxicokinetics
Killenger JM
1986
Calcium phosphates, calcium sulfate
and calcium carbonate bioavailability
and disposition in rats.
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-11
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
calcium pyrophosphate
26
7790-76-3
8.1.1 Skin irritation in vivo
Henderson L and
Joiner RL
1974
Toxicology lab report
trisodium phosphate (doedecahydrate)
4
7601-54-9
8.2.1 eye irritation in vivo
Glaza SM
1992
Primary eye irritation study of trisodium
phosphate dodecahydrate (saturated
solution at 22 degC) in rabbits
phosphoric acid
48
7664-38-2
8.1.1 Skin irritation in vivo
1979
Phosphoric acid?
48
7664-38-2
8.2.1 eye irritation in vivo
Phosphoric acid?
48
7664-38-2
8.5.1 Acute toxicity, oral
Lewis CA
Imlay P and
Parke G
Terrel Y and
Parke G
1977
A dermal corrosion study in albino
rabbits. Compound: MCTR-67-79
Report on rabbit eye irritation
Compound: MCTR-192-77
Report on Oral LD50 in rats.
Compound: MCTR-192-77
1977
sodium tripolyphosphate
0
7758-29-4
8.1.1 Skin irritation in vivo
Becker J and
Parke G
1975
A primary dermal irritation study of
MCTR-5-75 on abraded and
nonabradedc skin of New Zealand
albino rabbits
sodium tripolyphosphate
0
7758-29-4
8.2.1 eye irritation in vivo
Becker J and
Parke G
1975
The effects of MCTR-5-75 on the eye
mucosa of New Zealand albino rabbits
ammonium polyphosphate
20
68333-79-9
8.5.1 Acute oral toxicity
Cuthbert JA
1990
AMGARD LR2: Acute toxicity (LD50)
test in rats
ammonium polyphosphate
20
68333-79-9
8.5.3 Acute toxicity, dermal
Cuthbert JA
1990
AMGARD LR2: Acute dermal irritation
test in rabbits
ammonium polyphosphate
20
68333-79-9
8.3 Skin senstisation
Tomlinson PP
1993
ammonium polyphosphate
20
68333-79-9
8.5.1 Acute toxicity, oral
Guest RL
1993
AMGARD LR2: Magnusson & Kligman
maximisation study in the Guinea pig
AMGARD LR4: Acute oral toxicity
(Limit test) in the rat
AMGARD LR2: Acute eye irritation test
in the rabbit
AMGARD LR4: acute dermal toxicity
(Limit test) in the rat
ammonium polyphosphate
20
68333-79-9
8.2.1 eye irritation in vivo
Tomlinson PP
1993
ammonium polyphosphate
20
68333-79-9
8.5.3 Acute toxicity, dermal
Guest RL
1993
ammonium polyphosphate
20
68333-79-9
8.3 Skin senstisation
Tomlinson PP
1993
ammonium polyphosphate
20
68333-79-9
8.5.3 Acute toxicity, dermal
Tomlinson PP
1993
ammonium polyphosphate
20
68333-79-9
8.2.1 eye irritation in vivo
Tomlinson PP
1993
ammonium polyphosphate
20
68333-79-9
8.5.2 Acute toxicity, inhalation
Tomlinson PP
1993
ammonium polyphosphate
20
68333-79-9
8.5.3, Acute toxicity, dermal
Snell K
1994
AMGARD MC(M): Acute inhalation
toxicity study four-hour exposure (nose
only) in the rat
AMGARD LR2: Acute dermal toxicity
(Limit test) in the rat
AMGARD LR4: Magnusson & Kligman
maximisation study in the guinea pig
AMGARD LR4: Acute dermal irritation
test in the rabbit
AMGARD LR4: Acute eye irritation test
in the rabbit
ammonium polyphosphate
20
68333-79-9
8.4.1 Mutagenicity in bacteria
Thompson PW
1995
AMGARD LR2: reverse mutation assay
"AMES TEST" using Salmonella
typhimurium
ammonium polyphosphate
20
68333-79-9
8.3 Skin senstisation
Cutherbert JA
and Neilson L
1996
Three flame retardant formulations. A
human skin patch test (46h exposure)
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-12
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
dipotassium phosphate
sub ID
CAS Nr.
13
7758-11-4
Endpoint
8.2.1 eye irritation
Authors
Terrel Y and
Parke G
Study
Year
Object
1975
The effects of MCTR-4-75 on the eye
mucosa of New Zealand albino rabbits
dipotassium phosphate
13
7758-11-4
8.1. skin irritation in vivo
Becker J and
Parke G
1975
A primary dermal irritation study of
MCTR-4-75 on abraded and
nonabraded skin of New Zealand albino
rabbits
dipotassium phosphate
13
7758-11-4
8.4 mutagenicity in bacteria
Jagannath DR
1977
Mutagenicity evaluation of MCTR-256
phosphoric acid
48
7664-38-2
8.5.1 Acute toxicity, oral
phosphoric acid
48
7664-38-2
8.5.1 Acute toxicity, oral
phosphoric acid
48
7664-38-2
?
?
Scholz and
Weigand
Scholz and
Weigand
phosphoric acid
48
7664-38-2
8.1.1 Skin irritation in vivo (?)
Weigand W
phosphoric acid
48
7664-38-2
8.5.3 Acute toxicity, dermal
phosphoric acid
48
7664-38-2
8.5.1 Acute toxicity, oral
Imlay P and
Parke G
Imlay P and
Parke G
?
?
Toxikologische Prüfung von
1967/68 reinigerkomponenten
1971?
1985
1977
1977
Pastöse Phosphorsäure. VP Kn 500
Phosorige Säure Prüng auf
Hautreizung am Kaninchen
Report on the acute dermal toxicity of
rabbits Compound: MCTR-192-77
Report on oral LD50 in rats.
Compound: MCTR-192-77
1976
Report on primary dermal irritation
study in rabbits. Compound: MCTR-19277
Report on rabbit eye irritation
Compound: MCTR-51-76
Becker J and
Parke G
1976
Report on primary dermal irritation
study in rabbits. Compound: MCTR-5176
Weigand W
1972
?
phosphoric acid
48
7664-38-2
8.1.1 Skin irritation in vivo
phosphoric acid
48
7664-38-2
8.2.1 eye irritation
Imlay P and
Parke G
Becker J and
Parke G
phosphoric acid
48
7664-38-2
8.1.1 Skin irritation in vivo
polyphosphoric acid
49
8017-16-1
8.5.1 Acute toxicity, oral
1977
polyphosphoric acid
49
8017-16-1
8.1.1 skin irritation in vivo
?
1973
Berict über die Prüfung der haut - und
schleimhautverträglichkeit von 3
emulgatoren und einem
reaktionsprodukt am kaninchen
tetrapotassium pyrophosphate
15
7320-34-5
8.2.1 eye irritation in vivo
Parke G
1975
The effects of MCTR-6-75 on the eye
mucosa of New Zealand albino rabbits
1975
A primary dermal irritation study of
MCTR-6-75 on abraded and
nonabraded skin of F New Zealand
albino rabbits.
tetrapotassium pyrophosphate
15
7320-34-5
8.1.1 skin irritation
tripotassium phosphate
14
7778-53-2
8.2.1 eye irritation in vivo
Tripotassium phosphate
14
7778-53-2
8.5.1 Acute toxicity, oral
Becker J and
Parke G
Parke G
Terrell Y and
Parke G
1975
The effects of MCTR-7-75 on the eye
mucosa of New Zealand albino rabbits
Acute oral toxicity in rats. Compound:
MCTR-7-75
1975
tripotassium phosphate
14
7778-53-2
8.1.1 skin irritation in vivo
Becker J and
Parke G
1975
A primary dermal irritation study of
MCTR-7-75 on abraded and
nonabraded skin of New Zealand albino
rabbits
tripotassium phosphate
14
7778-53-2
8.4.1 Mutagenicity in bacteria
Jagannath DR
1977
Mutagenicity evaluation of MCTR-258
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-13
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
monaluminium phosphate
sub ID
CAS Nr.
39
13530-50-2
Endpoint
8.2.1 eye irritation in vivo
Authors
Parke G
Study
Year
Object
1975
the effects of MCTR-2-75 on the eye
mucosa of New Zealand albino rabbit
monaluminium phosphate
39
13530-50-2
8.1.1 skin irritation in vivo
Becker J and
Parke G
1975
A primary dermal irritation study of
MCTR-2-75 on abraded and
nonabraded skin of New Zealand albino
rabbits
monaluminium phosphate
39
13530-50-2
8.2.1 eye irritation in vivo
Parke G
1975
the effects of MCTR-20-75 on the eye
mucosa of New Zealand albino rabbit
monaluminium phosphate
39
13530-50-2
8.1.1 skin irritation in vivo
Parke G
1975
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic, 90-day, oral
Smith PS
1972
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic, 90-day, oral
Smith PS
1972
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic, 90-day, oral
Reyna MS
1973
A primary dermal irritation study of
MCTR-20-75 on abraded and
nonabraded skin of New Zealand albino
rabbits
90-day subacute oral toxicity study with
LEVAIR in albino rats
90-day subacute oral toxicity study with
KASAL in albino rats
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic, 90-day, oral
Mastalski K.
1972
sodium aluminum phosphate
43
7785-88-8
8.6.2 subchronic, 90-day, oral
Mastalski K.
1972
90-day subacute oral toxicity study with
LEVAIR in female albino rats
90-day subacute oral toxicity study with
LEVAIR in Beagle dogs
90-day subacute oral toxicity study with
KASAL in Beagle dogs
potassium pentahydrogen
bis(phosphate)
55
14887-42-4
8.5.3 Acute toxicity, dermal
Moore GE
2006
Acute dermal toxicity study in rats Limit test
potassium pentahydrogen
bis(phosphate)
55
14887-42-4
8.2.1 eye irritation in vivo
Moore GE
2006
Primary eye irritation study in rabbits
potassium pentahydrogen
bis(phosphate)
55
14887-42-4
8.5.1 Acute toxicity, oral
Moore GE
2006
Acute toxicity up and down procedure
potassium pentahydrogen
bis(phosphate)
55
14887-42-4
8.1.1 skin irritation in vivo
Moore GE
2006
Primary skin irritation study in rabbits
potassium pentahydrogen
bis(phosphate)
55
14887-42-4
Water solubility
Mollandin G
2009
Determination of the water solubility of
potassium pentahydrogen
bis(phosphate)
potassium pentahydrogen
bis(phosphate)
55
14887-42-4
Dissociation constant
Fieseler A
2009
Determination of the dissociation
constant of potassium pentahydrogen
bis(phosphate) in water
monoaluminum phosphate
39
13530-50-2
relative density
Fieseler A
2009
Determination of the relative density of
potassium pentahydrogen
bis(phosphate)
8.5.1 Acute toxicity, oral
Kazimerierz Kita
2001
?
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-14
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
monoaluminum phosphate
39
13530-50-2
monoaluminum phosphate
39
13530-50-2
Authors
Study
Year
8.5.3 Acute toxicity, dermal
Kazimerierz Kita
2001
?
8.1.1 skin irritation
Kazimerierz Kita
2001
?
Endpoint
Object
Acute toxicity of ammonium phosphate
sulfate to the rainbow trout,
Onchorhynchus mykiss, dertermined
under static test conditions
Acute oral toxicity up and down
procedure in rats
Ammonium phosphate sulfate
N/A
12593-60-1
9.1.3 Short--term toxicity testing on fish
?
2000
Ammonium phosphate sulfate
N/A
12593-60-1
8.5.1 Acute toxicity, oral
?
2000
diammonium phosphate
19
7783-28-0
9.1.2 Growth inhibition study in aquatic plants
?
2000
diammonium phosphate
19
7783-28-0
8.4.2 In vitro cytogenicity study in mammalian cells
?
2000
diammonium phosphate
19
7783-28-0
8.5.1 Acute toxicity, oral
?
2000
Toxicity of diammonium phosphate
(DAP) to unicellular green alga,
Selenastrum capricornutum
In vitro mammalian chromosome
abberation test
Acute oral toxicity up and down
procedure in rats
4-week general toxicity and
reproductive / development toxicity
screening test
diammonium phosphate
19
7783-28-0
8.7.1 Screening for reproductive developmental
toxicity
?
2002
diammonium phosphate
19
7783-28-0
8.4.1 Mutagenicity in bacteria
?
2001
diammonium phosphate
19
7783-28-0
8.5.3 Acute toxicity, dermal
?
2000
Liquid ammonium polyphosphate
20
68333-79-9
9.1.3 Short-term toxicity testing on fish
?
2000
Liquid ammonium polyphosphate
20
68333-79-9
8.5.1 Acute toxicity, oral
?
2000
monoammonium phosphate
18
7722-76-1
8.5.3 Acute toxicity, dermal
?
2000
monoammonium phosphate
18
7722-76-1
9.1.3 Short-term toxicity testing on fish
?
2000
monoammonium phosphate
18
7722-76-1
8.5.1 Acute toxicity, oral
?
2000
TSP
N/A
65995-95-4
9.1.2 Growth inhibition study in aquatic plants
TSP
N/A
65995-95-5
8.4.2 In vitro cytogenicity study in mammalian cells
TSP
N/A
65995-95-6
8.4.1 Mutagenicity in bacteria
Aufderheide JA,
Bussard JB
Gudi R & Brown
C
Wagner VO &
Klug ML
TSP
N/A
65995-95-7
8.7.1 Screening for reproductive developmental
toxicity
Dent MP
Bacterial reverse mutation assay
Acute dermal toxicity study in rats Limit test
Acute toxicity of liquid polyphosphate to
the rainbow trout, Onchorhynchus
mykiss, dertermined under static test
conditions
Acute oral toxicity up and down
procedure in rats
Acute dermal toxicity study in rats Limit test
Acute toxicity of monoammonium
phosphate to the rainbow trout,
Onchorhynchus mykiss, dertermined
under static test conditions
Acute oral toxicity up and down
procedure in rats
2001
Toxicity of granular triple sugar
phosphate (GTSP) to unicellular green
alga, Selenastrum capricornutum
(OECD 201)
In vitro mammalian chromosome
abberation test
2001
Bacterial reverse mutation assay
2002
4-week general toxicity and
reproductive / development toxicity
screening test
2000
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-15
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
STPP
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
7758-29-4
STPP
STPP
0
0
7758-29-4
7758-29-4
STPP
0
STPP
Endpoint
Authors
9.1.3 Short -term toxicity to fish
Study
Year
Object
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
Short-term toxicity to fish
Skin irritation
Skin irritation
Skin irritation
Eye irritation rabbits
Eye irritation rabbits
Clinical sensitisation
Clinical sensitisation
Clinical sensitisation
Clinical sensitisation
Clinical sensitisation
Clinical sensitisation
Clinical sensitisation
Clinical sensitisation
Clinical sensitisation
Acute toxicity
Acute toxicity
Acute toxicity
Acute toxicity
Acute toxicity
Short-term repeated dose
Subchronic toxicity
Subchronic toxicity
Subchronic toxicity
8.6.1 short-term repeated dose, oral, 28-day
?
?
?
?
Short-term repeated dose
Short-term repeated dose
7758-29-4
8.9.1 Chronic toxicity Dermal
?
?
Carcinogenicity
0
7758-29-4
?
?
dipotassium phosphate
13
7758-11-4
8.9.2 Carcinogenicity study- dermal
OECD 422: 28-day repeated dose and reprotoxicity
study
2005
Carcinogenicity
OECD 422: 28-day repeated dose and
reprotoxicity study
phosphoric acid
48
2008
AMES test
STPP
0
7758-29-4
Water Solubility
2009
Water solubility
Sodium dihydrogenorthophosphate
2
7558-80-7
Water Solubility
2009
Water Solubility
Sodium dihydrogenorthophosphate
2
7558-80-7
Melting point
2009
Melting point
Sodium dihydrogenorthophosphate
2
7558-80-7
8.3 Skin sensitisation
2009
Skin sensitisation
Sodium dihydrogenorthophosphate
2
7558-80-7
8.5.1 Acute toxicity, oral
2009
Acute toxicity, oral
Sodium dihydrogenorthophosphate
2
7558-80-7
relative density
2010
relative density
8.1.1 Skin Irritation/ Corrosion In-vivo
8.1.1 Skin Irritation/ Corrosion In-vivo
8.1.1 Skin Irritation/ Corrosion In-vivo
8.2.2 Eye Irritation/ Corrosion: In-vivo
8.2.2 Eye Irritation/ Corrosion: In-vivo
8.3 Skin sensitisation
8.3 Skin senstisation
8.3 Skin senstisation
8.3 Skin senstisation
8.3 Skin senstisation
8.3 Skin senstisation
8.3 Skin senstisation
8.3 Skin senstisation
8.3 Skin senstisation
8.5.1 Acute Toxicity: Oral
8.5.1 Acute Toxicity: Oral
8.5.1 Acute Toxicity: Oral
8.5.1 Acute Toxicity: Oral
8.5.1 Acute Toxicity: Oral
8.6.1 short-term repeated dose, oral, 28-day
8.6.2 subchronic, 90-day, oral
8.6.2 subchronic, 90-day, oral
8.6.2 subchronic, 90-day, oral
8.6.1 Short-term Repeated Dose Toxicity: Inhalation
Reverse mutation assay (AMES)
Shim YH
Choi S.A, Hong
E.K
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-16
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Disodium hydrogenorthophosphate
sub ID
CAS Nr.
3
7558-79-4
Endpoint
Authors
Water Solubility
Study
Year
2009
Object
Water Solubility
Disodium hydrogenorthophosphate
3
7558-79-4
Melting point
2009
Melting point
Disodium hydrogenorthophosphate
Trisodium orthophosphate
Trisodium orthophosphate
Trisodium orthophosphate
monopotassium phosphate
monopotassium phosphate
monopotassium phosphate
monopotassium phosphate
dipotassium phosphate
dipotassium phosphate
dipotassium phosphate
3
4
4
4
12
12
12
12
13
13
13
7558-79-4
7601-54-9
7601-54-9
7601-54-9
7778-77-0
7778-77-0
7778-77-0
7778-77-0
7758-11-4
7758-11-4
7758-11-4
8.5.1 Acute toxicity, oral
Water Solubility
Melting point
8.5.1 Acute toxicity, oral
Boiling point
Vapour pressure
Water Solubility
relative density
Melting point
Water Solubility
relative density
2009
2009
2009
2009
2009
2009
2009
2010
2009
2009
2010
Acute toxicity, oral
Water Solubility
Melting point
Acute toxicity, oral
Boiling point
Vapour pressure
Water Solubility
relative density
Melting point
Water Solubility
relative density
dipotassium phosphate
dipotassium phosphate
tripotassium orthophosphate
13
13
14
7758-11-4
7758-11-4
7778-53-2
Activated sludge respiration inhibition
Acute oral toxicity
Water Solubility
2010
2010
2009
Activated sludge respiration inhibition
acute oral toxicity
Water solubility
Calcium
bis(dihydrogenorthophosphate) /
monocalcium phosphate
21
7758-23-8
Melting point
2009
Melting point
Calcium
bis(dihydrogenorthophosphate) /
monocalcium phosphate
21
7758-23-8
Water Solubility
2009
Water Solubility
Calcium
bis(dihydrogenorthophosphate) /
monocalcium phosphate
21
7758-23-8
In vitro eye irritation
2009
Eye Irritation, in vitro
Calcium
bis(dihydrogenorthophosphate) /
monocalcium phosphate
21
7758-23-8
Eye irritation, in vivo
2010
eye irritation in vivo
Calcium
bis(dihydrogenorthophosphate) /
monocalcium phosphate
21
7758-23-8
Acutr inhalation
2010
Acute toxicity: inhalation
22
7757-93-9
Melting point
2009
Melting point
Water Solubility
2009
Water Solubility
8.2.2 Eye Irritation, in vitro
Melting point
Water Solubility
Eye Irritation, in vitro
Melting point
Water Solubility
Eye Irritation, in vitro
Skin irritation, in vitro
Skin corrosion, in vitro
Acute toxicity, oral
eye irritation in vivo
Water solubility
Mouse Lymphoma assay
calcium hydrogenorthophosphate /
Dicalcium phosphate
calcium hydrogenorthophosphate /
Dicalcium phosphate
calcium hydrogenorthophosphate /
Dicalcium phosphate
Tricalcium bis(orthophosphate)
Tricalcium bis(orthophosphate)
Tricalcium bis(orthophosphate)
Tricalcium bis(orthophosphate)
Tricalcium bis(orthophosphate)
Tricalcium bis(orthophosphate)
Tricalcium bis(orthophosphate)
tricalcium phosphate
22
7757-93-9
22
23
23
23
23
23
23
23
24
7757-93-9
7758-87-4
7758-87-4
7758-87-4
7758-87-4
7758-87-4
7758-87-4
7758-87-4
12167-74-7
8.2.2 Eye Irritation, in vitro
8.1.1 Skin irritation, in vitro
8.1.1 Skin corrosion, in vitro
8.5.1 Acute toxicity, oral
Eye irritation, in vivo
Water Solubility
2009
2009
2009
2009
2009
2009
2009
2010
2009
tricalcium phosphate
24
12167-74-7
8.4.3 In vitro gene mutation study in mammalian cells
2009
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-17
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Dimagnesium phosphate-3-hydrate
sub ID
CAS Nr.
Endpoint
29
7757-86-0
Melting point
Authors
Study
Year
Object
2009
Melting point
Dimagnesium phosphate-3-hydrate
29
7757-86-0
Water Solubility
2009
Water Solubility
Dimagnesium phosphate-3-hydrate
29
7757-86-0
8.2.2 Eye Irritation, in vitro
2009
Eye Irritation, in vitro
Dimagnesium phosphate-3-hydrate
29
7757-86-0
8.1.1 Skin irritation, in vitro
2009
Skin irritation, in vitro
Dimagnesium phosphate-3-hydrate
29
7757-86-0
8.1.1 Skin corrosion, in vitro
2009
Skin corrosion, in vitro
Dimagnesium phosphate-3-hydrate
29
7757-86-0
8.5.1 Acute toxicity, oral
2009
Acute toxicity, oral
Trimagnesium phosphate-4-hydrate
30
7757-87-1
Melting point
2009
Melting point
Trimagnesium phosphate-4-hydrate
30
7757-87-1
Water Solubility
2009
Water Solubility
Trimagnesium phosphate-4-hydrate
30
7757-87-1
8.4.1 In vitro gene mutation study in bacteria
2009
AMES
Trimagnesium phosphate-4-hydrate
30
7757-87-1
8.4.2. In vitro cytogenicity assay
2009
Chromosomal abberation test
Trimagnesium phosphate-4-hydrate
Magnesium
bis(dihydrogenorthophosphate)
Magnesium
bis(dihydrogenorthophosphate)
iron orthophosphate
iron orthophosphate
30
7757-87-1
8.4.3 In vitro gene mutation study in mammalian cells
2009
Muse Lymphoma assay
31
13092-66-5
Melting point
2009
Melting point
31
27
27
13092-66-5
10045-86-0
10045-86-0
Water Solubility
Melting point
Water Solubility
2009
2009
2009
Water Solubility
Melting point
Water Solubility
Trimanganese bis(orthophosphate)
33
14154-09-7
Melting point
2009
Melting point
Trimanganese bis(orthophosphate)
Manganese bis(dihydrogen
phosphate)
Manganese bis(dihydrogen
phosphate)
33
14154-09-7
Water Solubility
2009
Water Solubility
34
18718-07-5
Melting point
2009
Melting point
34
18718-07-5
Water Solubility
2009
Water Solubility
Dimanganese phosphate-2-hydrate
35
51349-94-1
Melting point
2009
Melting point
Dimanganese phosphate-2-hydrate
Tricopper bis(orthophosphate)
Tricopper bis(orthophosphate)
Dicopper hydroxide phosphate
Dicopper hydroxide phosphate
Boron orthophosphate
Boron orthophosphate
35
36
36
38
38
44
44
51349-94-1
7798-23-4
7798-23-4
12158-74-6
12158-74-6
13308-51-5
13308-51-5
Water Solubility
Melting point
Water Solubility
Melting point
Water Solubility
Melting point
Water Solubility
2009
2009
2009
2009
2009
2009
2009
Water Solubility
Melting point
Water solubility
Melting point
Water Solubility
Melting point
Water Solubility
Aluminium tris dihydrogenphosphate
39
13530-50-2
Melting point
2009
Melting point
Aluminium tris dihydrogenphosphate
39
13530-50-2
Water Solubility
2009
Water Solubility
Aluminium tris dihydrogenphosphate
39
13530-50-2
Relative density
2010
Relative density
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-18
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Aluminium tris dihydrogenphosphate
Aluminium orthophosphate
Aluminium orthophosphate
Aluminium orthophosphate
Aluminium orthophosphate
Aluminium orthophosphate
39
40
40
40
40
40
13530-50-2
7784-30-7
7784-30-7
7784-30-7
7784-30-7
7784-30-7
Aluminium orthophosphate
40
7784-30-7
8.4.1 In vitro gene mutation study in bacteria
2009
AMES
Aluminium orthophosphate
40
7784-30-7
8.4.2. In vitro cytogenicity assay
2009
Chromosomal abberation test
Aluminium orthophosphate
Aluminium orthophosphate
Aluminium orthophosphate
40
40
40
7784-30-7
7784-30-7
7784-30-7
8.4.3 In vitro gene mutation study in mammalian cells
8.1.1 Skin corrosion, in vitro
8.5.1 Acute toxicity, oral
2009
2009
2009
Muse Lymphoma assay
Skin corrosion, in vitro
Acute toxicity, oral
Aluminium orthophosphate
sodium aluminium phosphate 1:3:8
sodium aluminium phosphate 1:3:8
sodium aluminium phosphate 1:3:8
sodium aluminium phosphate 3:2:8
sodium aluminium phosphate 3:2:8
40
43
43
43
43
43
7784-30-7
7785-88-8
7785-88-8
7785-88-8
7785-88-8
7785-88-8
Activated sludge respiration inhibition
Melting point
Water Solubility
Relative density
Melting point
Water Solubility
2010
2009
2009
2010
2009
2009
Activated sludge respiration inhibition
Melting point
Water Solubility
Relative density
Melting point
Water Solubility
Disodium dihydrogen pyrophosphate
5
7758-16-9
Water Solubility
2009
Water Solubility
Disodium dihydrogen pyrophosphate
5
7758-16-9
Melting point
2009
Melting point
Acute inhalation toxicity
Melting point
Water Solubility
2010
2009
2009
2009
2009
2009
8.2.2 Eye Irritation, in vitro
8.2.2 Eye Irritation, in vivo
8.1.1 Skin irritation, in vitro
Object
Acute toxicity: inhalation
Melting point
Water Solubility
Eye Irritation, in vitro
Eye Irritation, in vivo
Skin irritation, in vitro
Disodium dihydrogen pyrophosphate
5
7758-16-9
8.3 Skin sensitisation
2009
Skin sensitisation
Disodium dihydrogen pyrophosphate
5
7758-16-9
8.2.2 Eye irritation , in vitro
2009
Eye irritation, in vitro
Disodium dihydrogen pyrophosphate
5
7758-16-9
eye irritation, in vivo
2010
eye irritation, in vivo
Disodium dihydrogen pyrophosphate
Trisodium hydrogen diphosphate
Trisodium hydrogen diphosphate
Trisodium hydrogen diphosphate
Trisodium hydrogen diphosphate
Trisodium hydrogen diphosphate
Trisodium hydrogen diphosphate
tetrasodium pyrophosphate
tetrasodium pyrophosphate
tetrasodium pyrophosphate
tetrasodium pyrophosphate
tetrasodium pyrophosphate
tetrapotassium pyrophosphate
tetrapotassium pyrophosphate
5
6
6
6
6
6
6
7
7
7
7
7
15
15
7758-16-9
14691-80-6
14691-80-6
14691-80-6
14691-80-6
14691-80-6
14691-80-6
7722-88-5
7722-88-5
7722-88-5
7722-88-5
7722-88-5
7320-34-5
7320-34-5
Relative density
Melting point
Water Solubility
Relative density
Melting point
Water Solubility
8.2.2 Eye Irritation, in vitro
8.1.1 Skin irritation, in vitro
8.5.1 Acute toxicity, oral
OECD 431 In vitro skin corrosion study
Water Solubility
8.5.1 Acute toxicity, oral
Eye irritation, in vitro - BCOP
Relative density
eye irritation, in vivo
Water Solubility
Relative density
2010
2009
2009
2009
2009
2009
2010
2009
2009
2010
2010
2010
2009
2010
8.2.2 Eye Irritation, in vitro
8.1.1 Skin irritation, in vitro
8.5.1 Acute toxicity, oral
skin corrosion in vitro
Water Solubility
8.5.1 Acute toxicity, oral
Eye irritation in vitro
Relative density
eye irritation, in vivo
Water solubility
Relative density
calcium dihydrogenpyrophosphate
25
14866-19-4
Melting point
2009
Melting point
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-19
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
calcium dihydrogenpyrophosphate
Dicalcium pyrophosphate
Dicalcium pyrophosphate
Dicalcium pyrophosphate
Tetrairon tris(pyrophosphate)
Tetrairon tris(pyrophosphate)
copper (II)-pyrophosphate
copper (II)-pyrophosphate
magnesium pyrophosphate
magnesium pyrophosphate
Pentapotassium triphosphate
Pentapotassium triphosphate
Pentapotassium triphosphate
Pentapotassium triphosphate
25
26
26
26
28
28
37
37
57
57
16
16
16
16
14866-19-4
7790-76-3
7790-76-3
7790-76-3
10058-44-3
10058-44-3
10102-90-6
10102-90-6
13446-24-7
13446-24-7
13845-36-8
13845-36-8
13845-36-8
13845-36-8
Water Solubility
Melting point
Water Solubility
Skin corrosion - in vitro; screening
Melting point
Water Solubility
Melting point
Water Solubility
Water Solubility
in vitro skin corrosion
Water Solubility
Melting point
8.5.1 Acute toxicity, oral
Relative density
2009
2009
2009
2011
2009
2009
2009
2009
2009
2011
2009
2009
2009
2010
Water Solubility
Melting point
Water Solubility
skin corrosion in vitro
Melting point
Water Solubility
Melting point
Water Solubility
Water solubility
in vitro skin corrosion
Water Solubility
Melting point
Acute toxicity, oral
Relative density
Sodium potassium tripolyphosphate /
pentapotassium pentasodium
bis(triphosphate)
46
24315-83-1
Melting point
2009
Melting point
Sodium potassium tripolyphosphate /
pentapotassium pentasodium
bis(triphosphate)
46
24315-83-1
Water Solubility
2009
Water solubility
Sodium potassium tripolyphosphate /
pentapotassium pentasodium
bis(triphosphate)
46
24315-83-1
8.5.1 Acute toxicity, oral
2009
Acute toxicity, oral
Sodium potassium tripolyphosphate /
pentapotassium pentasodium
bis(triphosphate)
46
24315-83-1
8.1.1 Skin irritation, in vitro
2009
Skin irritation, in vitro
Sodium potassium tripolyphosphate /
pentapotassium pentasodium
bis(triphosphate)
46
24315-83-1
8.1.1 Skin corrosion, in vitro
2009
Skin corrosion, in vitro
Sodium potassium tripolyphosphate /
pentapotassium pentasodium
bis(triphosphate)
Aluminium tripolyphosphate
Aluminium tripolyphosphate
Trisodium trimetaphosphate
Trisodium trimetaphosphate
Trisodium trimetaphosphate
46
41
41
8
8
8
24315-83-1
13939-25-8
13939-25-8
7785-84-4
7785-84-4
7785-84-4
8.2.2 Eye Irritation, in vitro
Melting point
Water Solubility
Melting point
Water Solubility
Hydrolysis as a function of pH
2009
2009
2009
2009
2009
2009
Eye Irritation, in vitro
Melting point
Water Solubility
Melting point
Water Solubility
Hydrolysis as a function of pH
Trisodium trimetaphosphate
Trisodium trimetaphosphate
Trisodium trimetaphosphate
Trisodium trimetaphosphate
Trisodium trimetaphosphate
Sodium metaphosphate
Sodium metaphosphate
Sodium metaphosphate
Sodium metaphosphate
8
8
8
8
8
10
10
10
10
7785-84-4
7785-84-4
7785-84-4
7785-84-4
7785-84-4
10124-56-8
10124-56-8
10124-56-8
10124-56-8
Oxidising properties expert statement
Explosivity expert statement
8.5.1 Acute oral toxicity
8.3 Skin sensitisation
Relative density
Water Solubility
Melting point
Water Solubility
Hydrolysis as a function of pH
2009
2009
2009
2009
2010
2009
2009
2009
2009
Oxidising properties expert statement
Explosivity expert statement
Acute oral toxicity
Skin sensitisation
relative density
Water Solubility
Melting point
Water Solubility
Hydrolysis as a function of pH
Sodium metaphosphate
Sodium metaphosphate
Sodium metaphosphate
10
10
10
10124-56-8
10124-56-8
10124-56-8
Oxidising properties expert statement
Explosivity expert statement
8.3 Skin sensitisation
2009
2009
2009
Oxidising properties expert statement
Explosivity expert statement
Skin sensitisation
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-20
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
Sodium metaphosphate
Sodium metaphosphate
Sodium metaphosphate
Sodium metaphosphate
10
10
10
10
10124-56-8
10124-56-8
10124-56-8
10124-56-8
8.5.1 Acute oral toxicity
Relative density
Acute toxicity to rainbow trout
Algal growth inhibition
2009
2010
2010
2010
Acute oral toxicity
Relative density
Acute toxicity to rainbow trout
Algal growth inhibition
Sodium metaphosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
10
47
47
47
10124-56-8
10163-15-2
10163-15-2
10163-15-2
Activated sludge respiration inhibition
Melting point
Water Solubility
Hydrolysis as a function of pH
2010
2009
2009
2009
Activated sludge respiration inhibition
Melting point
Water Solubility
Hydrolysis as a function of pH
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
47
47
47
47
47
47
10163-15-2
10163-15-2
10163-15-2
10163-15-2
10163-15-2
10163-15-2
Oxidising properties expert statement
Explosivity expert statement
8.3 Skin sensitisation
8.1.1 Skin corrosion in vitro
8.1.1 Skin corrosion in vitro
8.2.2 Eye irritation in vitro
2009
2009
2009
2009
2009
2009
Oxidising properties expert statement
Explosivity expert statement
Skin sensitisation
Skin irritation in vitro
Skin corrosion in vitro
Eye irritation in vitro
Disodium fluorophosphate
47
10163-15-2
8.4.1 In vitro gene mutation study in bacteria
2009
AMES
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
47
47
47
47
47
10163-15-2
10163-15-2
10163-15-2
10163-15-2
10163-15-2
8.4.3 In vitro gene mutation study in mammalian cells
7.4 Relative Density
Acute toxicity to rainbow trout
Acute toxicity to Daphnia magna
Algal growth inhibition
2009
2010
2010
2010
2010
Mouse Lymphoma assay
7.4 Relative Density
Acute toxicity to rainbow trout
Acute toxicity to Daphnia magna
Algal growth inhibition
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
Disodium fluorophosphate
47
47
47
47
47
47
10163-15-2
10163-15-2
10163-15-2
10163-15-2
10163-15-2
10163-15-2
Activated sludge respiration inhibitin
Soil adsorption coefficient
OECD 422 - range finder
OECD 422 -FULL STUDY
Eye irritation, in vivo
acute toxicity: inhalation
2010
2010
2010
2010
2010
2010
Activated sludge respiration inhibitin
Soil adsorption coefficient
OECD 422 - range finder
OECD 422 -FULL STUDY
Eye irritation, in vivo
Acute toxicity: inhalation
All substances
Dissociation constant
2009
Dissociation constant
Group 1: orthophosphates
Oxidising properties expert statement
2009
Oxidising properties expert statement
Group 1: orthophosphates
Explosivity expert statement
2009
Explosivity expert statement
TBC -Group 2: diphosphates
Hydrolysis as a function of pH
2009
Hydrolysis as a function of pH
Group 2: diphosphates
Oxidising properties expert statement
2009
Oxidising properties expert statement
Group 2: diphosphates
Explosivity expert statement
2009
Explosivity expert statement
TBC -Group 3: triphosphates
Hydrolysis as a function of pH
2009
Hydrolysis as a function of pH
Group 2: triphosphates
Oxidising properties expert statement
2009
Oxidising properties expert statement
Group 2: triphosphates
Explosivity expert statement
2009
Explosivity expert statement
phosphoric acid
48
Reverse mutation assay (AMES)
2010
AMES
phosphoric acid
48
8.4.3 In vitro gene mutation study in mammalian cells
2010
Mouse Lymphoma assay
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-21
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
Endpoint
Authors
Study
Year
sub ID
CAS Nr.
Object
HiPeak - mixtue of MKP and DKP
N/A
N/A
6.1.1. Short-term toxicity to fish
Priestly S
2010
HiPeak - mixtue of MKP and DKP
N/A
N/A
6.1.3 Short-term toxicity to invertebrates
Priestly S
2010
HiPeak - mixtue of MKP and DKP
Trisodium trimetaphosphate
N/A
8
N/A
7785-84-4
6.1.5 Toxicity to aqautic algae and cyanobacteria
Acute toxicity to Daphnia magna
vryenhoef H
Weber B
2010
2010
Short-term toxicity to fish
6.1.3 Short-term toxicity to
invertebrates
6.1.5 Toxicity to aqautic algae and
cyanobacteria
Acute toxicity to Daphnia magna
Trisodium trimetaphosphate
8
7785-84-4
Algal growth inhibition
Weber B
2010
Algal growth inhibition
phosphoric acid
48
AMES
Choi SA
2008
In vitro gene mutation in bacterial cells
reaction mass of MCP and DCP
60
Melting point
2010
Melting point
reaction mass of MCP and DCP
60
Relative density
2010
Relative density
reaction mass of MCP and DCP
60
Water Solubility
2010
Water Solubility
reaction mass of MCP and DCP
60
Acute toxicity: oral
2010
acute toxicity: oral
reaction mass of MCP and DCP
60
in vitro skin irritation
2010
in vitro skin irritation
reaction mass of MCP and DCP
60
Ex vivo skin corrosion
2010
Ex vivo skin corrosion
reaction mass of MCP and DCP
60
In vitro eye irritation
2010
In vitro eye irritation
reaction mass of MCP and DCP
60
Acute eye irritation
2010
Acute eye irritation
iron orthophosphate
27
Relative density
2011
Relative density
10045-86-0
iron orthophosphate
27
10045-86-0
Activated Sludge Respiration Inhibition
2011
Activated Sludge Respiration Inhibition
iron orthophosphate
27
10045-86-0
Acute inhalation toxicity
2011
Acute inhalation toxicity
iron orthophosphate
27
10045-86-0
2011
iron orthophosphate
27
10045-86-0
Skin sensitisation
Mouse Lymphoma Assay (gene mutation in
mammalian cells)
2011
Local lymph node assay
Mouse Lymphoma Assay (gene
mutation in mammalian cells)
iron orthophosphate
27
10045-86-0
Acute oral toxicity
2011
Acute oral toxicity
iron orthophosphate
27
10045-86-0
in vitro skin corrosion
2011
in vitro skin corrosion
iron orthophosphate
27
10045-86-0
in vitro skin irritancy
2011
in vitro skin irritancy
iron orthophosphate
27
10045-86-0
in vitro eye irritancy
2011
in vitro eye irritancy
iron orthophosphate
27
10045-86-0
ex-vivo REET
2011
ex-vivo REET
iron orthophosphate
27
10045-86-0
Acute eye
2011
Acute eye
iron orthophosphate
27
10045-86-0
Agal growth inhibition
2011
Agal growth inhibition
Diphosphric acid, sodium salt
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
5
7758-16-9
27
Acute oral toxicity
Assesment of Dermal toxicity with NEU
1165 M in the rat
8.5.1 Acute toxicity, oral
?
2009
10045-86-0
8.5.3. Acute dermal toxicity
Untenwiehe M
1996
27
10045-86-0
8.2.1 Eye irritation in vivo
Eye irritation in vivo
27
10045-86-0
8.5.1 Acute oral toxicity
Acute oral toxicty
27
10045-86-0
Acute toxicity to birds
Acute toxicity to birds
27
10045-86-0
9.4.1. Acute toxicty to soil invertebrates
Acute toxicty to soil invertebrates
27
10045-86-0
9.4.1. Acute toxicty to soil invertebrates
Acute toxicty to soil invertebrates
27
10045-86-0
7.10. flammability
27
10045-86-0
8.1.1 Primary skin irritation
Untenwiehe M
1996
Flammability
Primary skin irritation
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-22
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
sub ID
CAS Nr.
Endpoint
iron orthophosphate / Ferric phosphate
iron orthophosphate /NEU 1165M
(iron (III) phosphate)
27
10045-86-0
8.1.1 Primary skin irritation
Authors
Berndt A
Study
Year
2000
Object
Primary skin irritation / corrosion study
27
10045-86-0
9.4.1. Acute toxicty to soil invertebrates
iron orthophosphate / Eisen (III)phosphate (ferric(III) phosphate .
4H20)
Acute toxicty to soil invertebrates
27
10045-86-0
9.1.5. Long-term toxicity to Daphnia
Heintze A
1997
Long-term toxicity to Daphnia
iron orthophosphate / Eisen (III)phosphate (ferric(III) phosphate .
4H20)
27
10045-86-0
9.1.3. Short-term toxicity testing on fish
Heintze A
1997
Short-term toxicity testing on fish
iron orthophosphate / Eisen (III)phosphate (ferric(III) phosphate .
4H20)
27
10045-86-0
9.1.2 Growth inhibition study in aquatic plants
Dengler D
1997
Growth inhibition study in aquatic plants
Ferric phosphate
27
10045-86-0
Acute toxicity, oral
Berndt A,
1999
Assessment of acute oral toxicity with
Ferric phosphate in the rat (acute toxic
class method)
Ferric phosphate
27
10045-86-0
Eye irritation
Berndt A,
2000
Eye irritation / corrosion in vivo
disodium dihydrogen pyrophosphate
5
14691-80-6
Unknown
2002
disodium dihydrogen pyrophosphate
5
14691-80-6
Acute dermal toxicity (OECD 402)
In vitro genen mutation in bacteria (AMES) (OECD
471)
Unknown
2002
disodium dihydrogen pyrophosphate
5
14691-80-6
In vitro chromosomal abberation study (OECD 473)
Unknown
2002
Acute dermal toxicity (OECD 402)
In vitro genen mutation in bacteria
(AMES) (OECD 471)
In vitro chromosomal abberation study
(OECD 473)
disodium dihydrogen pyrophosphate
5
14691-80-6
Aquatic toxicity to fish (OECD ?)
Unknown
2002
disodium dihydrogen pyrophosphate
5
14691-80-6
Aquatic toxicity to invertebrates (OECD ?)
Unknown
calcium hydrogenorthophosphate
22
7757-93-9
Unknown
calcium hydrogenorthophosphate
22
7757-93-9
Acute oral toxicity (OECD 401)
In vitro genen mutation in bacteria (AMES) (OECD
471)
calcium hydrogenorthophosphate
22
7757-93-9
In vitro chromosomal abberation study (OECD 473)
Unknown
calcium hydrogenorthophosphate
22
7757-93-9
Aquatic toxicity to fish (OECD ?)
Unknown
calcium hydrogenorthophosphate
22
7757-93-9
Aquatic toxicity to invertebrates (OECD ?)
Unknown
2002
2006/20
08
2006/20
08
2006/20
08
2006/20
08
2006/20
08
tricalcium bis(orthophosphate)
23
7758-87-4
in vivo mammalian mouse micronucleus
Unknown
2005
in vivo mammalian mouse micronucleus
tricalcium bis(orthophosphate)
23
7758-87-4
Aquatic toxicity to fish (OECD ?)
Unknown
2005
Aquatic toxicity to fish (OECD ?)
tripotassium orthophosphate
14
7778-53-2
in vivo mammalian mouse micronucleus
Unknown
2007
in vivo mammalian mouse micronucleus
tripotassium orthophosphate
14
7778-53-2
Aquatic toxicity to fish (OECD ?)
Unknown
2007
tripotassium orthophosphate
14
7778-53-2
Unknown
2007
trisodium orthophosphate
4
7601-54-9
Aquatic toxicity to invertebrates (OECD ?)
In vitro genen mutation in bacteria (AMES) (OECD
471)
Unknown
2007
Aquatic toxicity to fish (OECD ?)
Aquatic toxicity to invertebrates (OECD
?)
In vitro genen mutation in bacteria
(AMES) (OECD 471)
tetrasodium pyrophosphate
7
7722-88-5
Acute oral toxicity (up and down procedure)
Villigran A
2010
Acute oral toxicity
magnesium dihydrogen pyrophosphate
58
20768-12-1
Acute oral toxicity - Class method (OECD 423)
Entzian K
2011
Budeheim Bioserv Magnesium pyro
IP58 tests report 2010: Acute oral
Unknown
Aquatic toxicity to fish (OECD ?)
Aquatic toxicity to invertebrates (OECD
?)
Acute oral toxicity (OECD 401)
In vitro genen mutation in bacteria
(AMES) (OECD 471)
In vitro chromosomal abberation study
(OECD 473)
Aquatic toxicity to fish (OECD ?)
Aquatic toxicity to invertebrates (OECD
?)
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-23
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
Endpoint
Authors
Study
Year
substance
sub ID
CAS Nr.
Object
magnesium dihydrogen pyrophosphate
58
20768-12-1
Genotoxicity (mouse lymphoma assay)
Entzian K
2011
Budeheim Bioserv Magnesium pyro
IP58 tests report 2010: Genotox
magnesium dihydrogen pyrophosphate
58
20768-12-1
Skin irritation in vivo
Entzian K
2011
Budeheim Bioserv Magnesium pyro
IP58 tests report 2010: skin irritation
magnesium dihydrogen pyrophosphate
58
20768-12-1
Acute eye irritation in vivo
Entzian K
2011
Budeheim Bioserv Magnesium pyro
IP58 tests report 2010: eye irritation
magnesium dihydrogen pyrophosphate
58
20768-12-1
Skin corrosion - in vitro; screening
Warren N
2011
Skin corrosion in vitro
Dicopper hydroxide phosphate
38
12158-74-6
Acute oral toxicity - OECD 423
Entzian K
2011
Budeheim Bioserv dicopper phosphate
IP38 tests report 2010: acute oral
Dicopper hydroxide phosphate
38
12158-74-6
Genotoxicity (mouse lymphoma assay)
Entzian K
2011
Budeheim Bioserv dicopper phosphate
IP38 tests report 2010: gentox
mammalian cells
Dicopper hydroxide phosphate
38
12158-74-6
In vitro gene mutation in bacteria
Entzian K
2011
Budeheim Bioserv dicopper phosphate
IP38 tests report 2010: gentox bacteria
Dicopper hydroxide phosphate
38
12158-74-6
Skin irritation in vivo
Entzian K
2011
Budeheim Bioserv dicopper phosphate
IP38 tests report 2010: skin irritation
Dicopper hydroxide phosphate
Aluminium orthophosphate
STPP
dicalcium phosphate (90%), plus 10%
MCP
dicalcium phosphate (97%), plus 3%
MCP
38
40
0
12158-74-6
7784-30-7
7758-29-4
Acute eye irritation in vivo
Skin irritation in vivo
Eye irritation
Entzian K
Giannini P
Durando J
2011
2008
2011
Budeheim Bioserv dicopper phosphate
IP38 tests report 2010: eye irritation
skin irritation in vivo
Eye irritation in vivo
22
7757-93-9
Eye irritation
Lowe C
2011
Eye irritation in vivo
22
7757-93-9
Eye irritation
Durando J
2011
Eye irritation in vivo
Calcium acid pyrophosphate (6679%), 16-24% MCP, 4-9% DCP, 1%
TCP
25
14866-19-4
Eye irritation
Durando J
2011
Eye irritation in vivo
Stabil 9 019 (Sodium aluminium
phosphate 65% and monocalcium
phosphate 35%)
43
7785-88-8
Eye irritation
Lowe C
2011
Eye irritation in vivo
sodium aluminium phosphate (>90%)
43
7785-88-8
Eye irritation
Durando J
2011
Eye irritation in vivo
One generation reproduction study in
rats with elemental phosphorus (IR-82215)
Blend B3 / pH 9.7: Rabbit enucleated
eye
Elemental phosphorus
tetrasodium pyrophosphate (+9.1%
STPP, 1.6% SAPP)
n/a
n/a
Reproductive toxicity
Schardain JL
1985
7
7722-88-5
eye irritiation
Pooles A
2011
5
7758-16-9
eye irritiation
Pooles A
2011
disodium dihydrogenpyrophosphate (+
4.2% TSPP)
tetrasodium pyrophosphate (+8.4%
SAPP)
tetrasodium pyrophosphate (+1.8%
SAPP)
7
7722-88-5
eye irritiation
Pooles A
2011
7
7722-88-5
eye irritiation
Pooles A
2011
Blend A1 / pH 5.0: Rabbit enucleated
eye
Blend A2 / pH 9.0: Rabbit enucleated
eye
Blend A3 / pH 9.7: Rabbit enucleated
eye
disodium dihydrogenpyrophosphate
(+9.1% STPP, 3.8% TSPP)
5
7758-16-9
eye irritiation
Pooles A
2011
Blend B1 / pH 5.5: Rabbit enucleated
eye
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-24
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
CAS Nr.
7
7722-88-5
eye irritiation
Pooles A
2011
7
7722-88-5
eye irritiation
Pooles A
2011
7
7722-88-5
eye irritiation
2011
Glass H polyphosphate - IP8?
8
7785-84-4
eye irritation
Pooles A
Barnett D and
Nixon G
Blend B2 / pH 9.0: Rabbit enucleated
eye
Blend B3 / pH 9.7: Acute eye irritation in
vivo
Blend A3 / pH 9.7: Acute eye irritation in
vivo
1972
Rabbit eye irritation
Glass H polyphosphate - IP8?
8
7785-84-4
dermal irritation
1972
dermal irritation
Glass H polyphosphate - IP8?
trimetaphosphate - IP8?
tripotassium phosphate (50% aqueous
solution)
8
8
7785-84-4
7785-84-4
Acute oral toxicity
Repeated dose, oral
1972
1973
Acute oral toxicity
Substance oral toxicity
14
7778-53-2
Skin irritation in vivo
Frank R, Nixon G
Whalen J and
Klusman W
Johnson GR
Frank R and
Nixon G
1976
skin irritation
Calcium dihydrogenpyrophosphate
dicalcium pyrophosphate
trisodium hydrogen diphosphate
trisodium hydrogen diphosphate
trisodium hydrogen diphosphate
trisodium hydrogen diphosphate
Trisodium trimetaphosphate
Trisodium trimetaphosphate
Trisodium trimetaphosphate
tripotassium orthophosphate
trimagnesium bis(orthophosphate)
trimagnesium bis(orthophosphate)
trimagnesium bis(orthophosphate)
25
26
6
6
6
6
8
8
8
14
30
30
30
14866-19-4
7790-76-3
14691-80-6
14691-80-6
14691-80-6
14691-80-6
7785-84-4
7785-84-4
7785-84-4
7778-53-2
7757-87-1
7757-87-1
7757-87-1
Skin corrosion - in vitro; screening
Acute oral toxicity
Acute oral toxicity
In vitro skin irritancy
Ex-vivo BCOP
Acute eye irritation
Acute toxicity to fish
Activated Sludge Respiration Inhibition
Acute inhalation toxicity
In vitro skin irritation
In vitro skin irritation
Ex-vivo BCOP
Acute eye irritation in rabbits
2011
1966
2012
2012
2012
2012
2012
2012
2012
2012
2012
2012
2012
Skin irritation
Acute oral toxicity
Acute oral toxicity
In vitro skin irritancy
BCOP
Acute eye irritation
Short-term toxicity to fish
ASRI
Acute inhalation toxicity
In vitro skin irritation
In vitro skin irritation
BCOP
Eye irritation
manganese bis(dihydrogen phosphate)
34
18718-07-5
Acute oral toxicity
2012
Acute oral toxicity
manganese bis(dihydrogen phosphate)
34
18718-07-5
in vitro skin corrosion
2012
in vitro skin corrosion
manganese bis(dihydrogen phosphate)
34
18718-07-5
in vitro skin irritancy
2012
in vitro skin irritancy
tetrasodium pyrophosphate (+9.1%
STPP, 7.6% SAPP)
tetrasodium pyrophosphate (+9.1%
STPP, 1.6% SAPP)
tetrasodium pyrophosphate (+1.8%
SAPP)
Endpoint
Authors
Study
Year
sub ID
Warren N
Nixon G
Object
manganese bis(dihydrogen phosphate)
34
18718-07-5
Ex-vivo BCOP
2012
BCOP
manganese bis(dihydrogen phosphate)
manganese hydrogen phosphate
manganese hydrogen phosphate
manganese hydrogen phosphate
manganese hydrogen phosphate
manganese hydrogen phosphate
Dicopper hydroxide phosphate
Aluminium orthophosphate
Sodium aluminium phosphate
Sodium aluminium phosphate
Sodium aluminium phosphate
34
35
35
35
35
35
38
40
43
43
43
18718-07-5
51349-94-1
51349-94-1
51349-94-1
51349-94-1
51349-94-1
12158-74-6
7784-30-7
7785-88-8
7785-88-8
7785-88-8
Acute eye irritation in rabbits
Acute oral toxicity
in vitro skin corrosion
in vitro skin irritancy
Ex-vivo BCOP
Acute eye irritation in rabbits
Acute inhalation toxicity
Local Lymph Node Assay
Acute oral toxicity
In vitro skin irritation
in vitro skin corrosivity
2012
2012
2012
2012
2012
2012
2012
2012
2012
2012
2012
Eye irritation
Acute oral toxicity
in vitro skin corrosion
in vitro skin irritancy
BCOP
Eye irritation
Acute inhalation toxicity
Skin sensitisation
Acute oral toxicity
In vitro skin irritation
in vitro skin corrosivity
aluminium dihydrogen triphosphate
41
13939-25-8
Acute oral toxicity
2012
Acute oral toxicity
aluminium dihydrogen triphosphate
41
13939-25-8
in vitro skin corrosion
2012
in vitro skin corrosive
aluminium dihydrogen triphosphate
41
13939-25-8
In vitro skin irritancy
2012
In vitro skin irritancy
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-25
Inorganic Phosphates (IP) Consortium - Company owned studies
IP Studies list - PART ** I **
substance
aluminium dihydrogen triphosphate
sub ID
CAS Nr.
41
13939-25-8
Endpoint
Ex-vivo eye irritancy
Authors
Study
Year
2012
Object
BCOP
aluminium dihydrogen triphosphate
41
13939-25-8
Acute eye irritation
2012
Acute eye irritation
aluminium dihydrogen triphosphate
41
13939-25-8
Acute inhalation toxicity
2012
Acute inhalation toxicity
Studies owned by the Consortium, by companies, or by other parties
16th April 2012 - page 2-26