Antenatal HIV Screening Programme Monitoring Report January to June 2014 Copyright The copyright owner of this publication is the Ministry of Health, which is part of the New Zealand Crown. The Ministry of Health permits the reproduction of material from this publication without prior notification, provided that all the following conditions are met: the content is not distorted or changed the information is not sold the material is not used to promote or endorse any product or service the material is not used in an inappropriate or misleading context having regard to the nature of the material any relevant disclaimers, qualifications or caveats included in the publication are reproduced the New Zealand Ministry of Health is acknowledged as the source Disclaimer This publication reports on information provided to the Ministry of Health by district health boards. Its purpose is to inform discussion and assist the ongoing development of the Antenatal HIV Screening Programme. All care has been taken in the production of this report, and the data was deemed to be accurate at the time of publication. However, the data may be subject to updates over time as further information is received. Before quoting or using this information, it is advisable to check the current status with the Ministry of Health. Acknowledgements Many people have assisted in the production of this report. In particular, the Ministry of Health would like to acknowledge those who have collected this information at the laboratories and district health boards, extracted and verified the information, and facilitated the analysis of the data. Citation: Ministry of Health. 2014. Antenatal HIV Screening Programme: Monitoring Report January to June 2014. Wellington: Ministry of Health. ISBN 978-0-478-42849-0 (online) HP 5926 Published in 2014 by the Ministry of Health PO Box 5013, Wellington 6145, New Zealand This document is available at www.nsu.govt.nz Contents Executive summary v 1 Introduction 1 1.1 Why offer screening for HIV in pregnancy? 1 1.2 Background to the universal offer of HIV screening in pregnancy in New Zealand 1 1.3 Programme monitoring and data collection 2 1.4 Information included in this report 3 1.5 Screening uptake calculations 4 1.6 Data limitations 5 2 3 Screening uptake 7 2.1 Antenatal HIV screening uptake by DHB 7 2.2 Antenatal HIV screening uptake by requestor 8 2.3 Antenatal HIV screening uptake by age group 11 2.4 Antenatal HIV screening uptake by ethnicity 13 2.5 Antenatal HIV screening uptake by NZDep 15 Initial reactive and confirmed positive results 17 3.1 Reactive EIA screening tests results 17 3.2 Confirmed HIV positive cases 17 References 18 Appendix 1: History of data collection and reporting processes 19 Appendix 2: Selected data fields and descriptions 20 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 iii List of Tables Table 1: Data provided by DHB, 1 January to 30 June 2014 3 Table 2: Records submitted with missing NHI numbers, 1 January to 30 June 2014 6 Table 3: Screening uptake by DHB, 1 January to 30 June 2014 7 Table 4: Screening uptake by requestor type, 1 January to 30 June 2014 9 Table 5: Screening uptake by DHB and requestor type, 1 January to 30 June 2014 10 Table 6: Screening uptake by age group, 1 January to 30 June 2014 11 Table 7: Screening uptake by DHB and age group, 1 January to 30 June 2014 12 Table 8: Screening uptake by ethnicity, 1 January to 30 June 2014 13 Table 9: Screening uptake by DHB and ethnicity, 1 January to 30 June 2014 14 Table 10: Screening uptake by NZDep2006 decile, 1 January to 30 June 2014 15 Table 11: Screening uptake by DHB and NZDep2006 decile, 1 January to 30 June 2014 16 Table 12: Initial reactive screening test results and confirmed HIV positive results, 1 January to 30 June 2014 17 List of Figures Figure 1: Data collection process from April 2010 to present 2 Figure 2: Screening uptake by DHB, 1 January to 30 June 2014 8 Figure 3: Screening uptake by requestor type, 1 January to 30 June 2014 9 Figure 4: Screening uptake by age group, 1 January to 30 June 2014 11 Figure 5: Screening uptake by ethnicity, 1 January to 30 June 2014 13 Figure 6: Screening uptake by NZDep2006 decile, 1 January to 30 June 2014 15 iv Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 Executive summary This report presents the data for the first half of 2014 and covers a six-month period of antenatal human immunodeficiency virus (HIV) screening. The information in this report is based on screening that occurred from 1 January to 3o June 2014. All district health boards (DHBs) are providing antenatal HIV screening information. Key points for the Antenatal HIV Screening Programme The Antenatal HIV Screening Programme is offered to all pregnant women and aims to reduce the risk of perinatal transmission of HIV. Antenatal HIV screening has been offered to women in all 20 DHBs since July 2010. Some individual DHBs started screening prior to this time. The National Screening Unit (NSU) is responsible for funding and monitoring this screening programme. No babies of women screened have been born with HIV since the programme was implemented. The data limitations identified in the report mean the National Screening Unit cannot monitor uptake of the programme comprehensively. The limitations do not impact on the care or management of women undergoing screening or diagnosed with HIV. The NSU continues to work with DHBs and laboratories to improve the data quality for this screening programme. Key points for January to June 2014 Data from all 20 DHBs was collected and reported on for this period. At the national level, the average uptake rate of antenatal HIV screening was 87 percent. Because of a small number of data issues, this figure may be slightly different from the true uptake rate. Nonetheless, it is reasonable to assume that it is the most accurate figure for the screening programme to this point. Across DHBs, screening uptake rates range from 59 percent to 100 percent. Uptake rates for the Auckland region, Northland, Canterbury, Nelson Marlborough and South Canterbury can only be estimated due to data issues. In particular, a proportion of the records in these DHBs did not include a National Health Index (NHI) number, which is a nationally unique identifier. The NSU therefore does not have sufficient information to assign these records an accurate DHB of domicile (that is, the DHB area in which the woman lives). Antenatal HIV screening uptake rates are analysed by requestor type, age group, ethnicity and deprivation status. While there are some small differences across these factors, they are generally not large enough to be significant. At the national aggregate level, there were 11 reactive enzyme immuno-assay (EIA) tests reported across this reporting period. This result is lower than other reporting periods, and well within the range of 1 in 1000 which was the initial programme prediction. There were no HIV positive case identified through screening for this reporting period. This is in line with the data reported by the AIDS Epidemiology Group. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 v 1 Introduction 1.1 Why offer screening for HIV in pregnancy? The primary purpose of screening for the human immunodeficiency virus (HIV) in pregnancy is to reduce the risk of perinatal transmission of HIV. Without diagnosis and treatment during pregnancy, the risk of transmission is around 25–32 percent. However, with diagnosis and appropriate treatment that risk is reduced to less than 1 percent (Dickson et al 2002; Rongkavilit and Asmar 2004; Ziegler and Graves 2004; Centers for Disease Control and Prevention 2007; National Screening Unit 2008). No cases of perinatal transmission of HIV have been identified in New Zealand among women who have had appropriate treatment during pregnancy. New Zealand has a low prevalence of HIV, and since 2006 the HIV epidemic among heterosexual people in New Zealand has seen a steady decline (AEG, 2014a). However, heterosexual transmission still remains the most common means of acquiring HIV in many parts of the world and specifically in the Asian Pacific region (UNAIDS, 2013). It is national policy that HIV screening be offered and recommended to all pregnant women, along with the other blood screening tests, as an integral part of antenatal care. Since July 2010, it has been a requirement that all pregnant women in New Zealand are offered screening for HIV, alongside the other tests included within the first antenatal blood screen, when they first present for antenatal care. Ensuring women make an informed decision about antenatal screening for HIV is a legal requirement under the Code of Health and Disability Services Consumers’ Rights, which is central to best practice in maternity care. 1.2 Background to the universal offer of HIV screening in pregnancy in New Zealand In 2005, the New Zealand Government directed the National Screening Unit (NSU) of the Ministry of Health to begin to implement a nationwide Universal Offer Antenatal HIV Screening Programme. It made this decision because there was evidence that the risk assessment approach to offering screening for HIV was not working. A 2004 report by the National Health Committee (National Health Committee 2004), and the 2005 release of the findings of a case by the Health and Disability Commissioner (HDC 2005), were both strong drivers for change. Before the national programme was implemented, Waikato District Health Board had made significant progress towards implementing an antenatal HIV screening programme in its region. It became the first district health board (DHB) to implement the national programme in March 2006. Between 2007 and 2010 the other DHBs also implemented the Antenatal HIV Screening Programme. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 1 1.3 Programme monitoring and data collection This report presents information for the Antenatal HIV Screening Programme between 1 January and 30 June 2014. This report presents data over a six-month timeframe. Previous to 2012, reporting was quarterly but, because a number of women have more than one test recorded during their pregnancy which creates the potential for over-reporting, six-monthly reporting has been implemented. Monitoring and evaluation of screening programmes are integral to good practice. Findings inform programme and provider performance against national indicators and ongoing policy development to ensure that services are safe for women and their babies. In 2006, the AIDS Epidemiology Group (AEG, University of Otago) developed a Monitoring and Evaluation Plan for the programme. AEG has overall responsibility for national surveillance of AIDS and HIV infection in New Zealand. AEG also began some qualitative research to review the impact of reactive screening or positive confirmatory results on women and their health care providers. This research concluded in June 2012 (McAllister et al 2013). In 2008, AEG began monitoring the Antenatal HIV Screening Programme. From July 2009 routine programme monitoring transferred to the NSU. Since this time the data collection, transfer and data validation have been reviewed and redesigned. The new process was implemented from April 2010 onwards, as described in Figure 1. AEG continues to receive notifications of most HIV positive results direct from laboratories. See Appendix 1 for greater detail on data collection processes before and after 1 April 2010. Figure 1: Data collection process from April 2010 to present 2 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 1.4 Information included in this report The data in this report relates to all 20 DHBs participating in the Antenatal HIV Screening Programme from 1 January to 30 June 2014. Table 1 below identifies whether or not data was received for monitoring purposes from each DHB and the date of programme implementation for each DHB. Table 1: Data provided by DHB, 1 January to 30 June 2014 DHB Month and year started screen Data provided Northland August 2008 Yes Waitemata April 2009 Yes Auckland April 2009 Yes Counties Manukau April 2009 Yes Waikato March 2006 Yes Lakes September 2008 Yes Bay of Plenty August 2008 Yes Tairawhiti April 2008 Yes Taranaki August 2008 Yes Hawke’s Bay July 2008 Yes Whanganui March 2010 Yes MidCentral May 2009 Yes Hutt Valley June 2009 Yes Capital & Coast May 2009 Yes Wairarapa July 2009 Yes Nelson Marlborough December 2009 Yes West Coast December 2008 Yes Canterbury April 2009 Yes South Canterbury July 2009 Yes Southern July 2010 Yes See Appendix 2 for a full list of data fields collected and a further description of each field. The national laboratory algorithm for antenatal HIV screening involves a two-step process. The first step is to do an HIV enzyme immuno-assay (EIA) test. The EIA test is low cost, rapid and very sensitive and specific for HIV (99.9% approximately). The results of an EIA test can be: non-reactive, which means that the woman is very unlikely to be infected with HIV low-level reactive, which is usually non-specific cross-reactivity and not related to HIV infection high-level reactive, which indicates likely HIV infection. Women who have a reactive EIA test result (low-level and high-level) are asked to provide a second blood sample for confirmatory testing. Confirmatory testing is done using a nucleic acid amplification test (NAAT) in the form of HIV viral load or PCR. This is intended to exclude or confirm HIV infection as quickly as possible, rather than waiting for a conclusive Western Blot test result which can take between three weeks and six months. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 3 1.5 Screening uptake calculations The screening uptake calculations are based on the following data fields. Records included in each six-month period Records included in this six-month period are based on the ‘Date initial sample received’, which must be between 1 January 2014 to 30 June 2014. DHB of domicile Each record is allocated to a DHB based on the National Health Index (NHI) information on the woman’s residential address. Where the NHI number is not provided (see Section 1.6 below on data limitations), then the DHB is shown as ‘not recorded’. Ethnicity and NZ Deprivation decile Ethnicity is prioritised based on NHI ethnicity information. All reporting ‘by NZDep decile’ is based on the NZDep decile as associated with the NHI-based residential address (domicile code). (Salmond et al 2007). Where the NHI number is missing, these fields are shown as ‘not reported’. Uptake rates To accurately calculate screening uptake, it is necessary to report information for all pregnant women and to record whether they have a blood test with or without an HIV test in a field called ‘Timing of AHIV screen’. The possible options are: 1 first set of antenatal bloods with an HIV test 2 first set of antenatal bloods without an HIV test 3 HIV test outside of first antenatal blood screening. The uptake rate for the purposes of this report is defined as the percentage of antenatal screens with an HIV component (option 1 or 3), and is calculated as follows: (n) (Women with HIV test as part of first antenatal bloods + Women with HIV test outside first antenatal bloods) x 100 (N) Women with antenatal blood screen (with or without HIV component) In calculating screening uptake for the purposes of monitoring, the NSU does not know whether the women who did not have an antenatal HIV test were not offered a test or were offered one but declined it. 4 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 1.6 Data limitations If there is missing or inaccurate data for any DHB, this will affect its uptake rates. The data issues generally relate to the following. No data or late data may be provided or the records may be incomplete, with the result that some records may not be included. This issue is much less prevalent than in the early days of programme implementation and has a limited effect on data quality. Laboratories may not provide DHBs with an NHI number for women who have antenatal bloods without an HIV test (that is, when women declined the HIV component of the test). This creates two main problems for the data.1 – With no NHI number, the records cannot be assigned a DHB of domicile, ethnicity or decile grouping. Where there is an NHI number, each of these fields is provided by matching records securely with the national NHI database. – Without a nationally unique identifier (NHI number), the NSU is unable to identify whether records are a duplicate. (Around 3–4 percent of women have duplicate records submitted in each reporting period.) As a result, the number of women screened may be over-counted. In this report unique laboratory identifiers were provided for the Auckland region DHBs and for Northland so that the issue of duplicates could be minimised. However, this approach does not resolve the issue of missing data on ethnicity, decile or DHB of domicile. The issue of missing NHI numbers does not affect all DHBs. Table 2 identifies the extent to which it applies in this report and includes women screened and unscreened for HIV. Also analysed has been the question of how likely it is that a DHB that is sent the data by the laboratory is also the DHB of domicile. For most DHBs, and specifically for Canterbury and Northland, the NSU is confident that the women with missing NHI numbers are likely to be resident in the region of the DHB that sent in their data. There is one laboratory covering the three DHBs in the Auckland region. The movement of women between the DHBs does not allow confidence in reporting by DHB so the combined uptake rate for these three DHBs is provided in the analysis tables in this report. The process is that antenatal HIV data is sent from the community laboratory where testing is performed through to the DHB for those women domiciled in that DHB. The DHB then check the data and send it on to the Ministry of Health. Data for Waitemata DHB illustrates the impact of the absence of NHI for those women who have antenatal bloods without an HIV test. If all records which have no NHI number were excluded from analysis, then the uptake rate would be close to 100 percent. On the other hand, if all these records were included, the uptake rate would be only 81 percent. The ‘true’ rate is most likely to be somewhere between these two figures. Because missing NHIs do not allow for DHB of domicile to be assigned the estimated rates are calculated based on the data sent in by the DHB and include records with a missing unique identifier. Using the example of South Canterbury the DHB sent in 458 records of which 269 had an HIV screen. This enables an estimated uptake of 59% to be calculated. 1 If a DHB is provided with NHI numbers by its laboratory and is confident that a large number of screens are not occurring outside of its region, then this issue is likely to have little effect on its uptake rates. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 5 Table 2: Records submitted with missing NHI numbers, 1 January to 30 June 2014 DHB submitting the records Number of records submitted Number of records with no NHI number provided by laboratory Percentage of all submitted records with no NHI number Northland 1,361 249 18.3 Waitemata 5,244 988 18.8 Auckland 5,839 1,023 17.5 Counties Manukau 5,552 479 8.6 Waikato 4,158 1 0.0 Lakes 1,081 0 0.0 Bay of Plenty 2,024 0 0.0 Tairawhiti 495 0 0.0 Taranaki 1,085 0 0.0 Hawke’s Bay 1,143 0 0.0 Whanganui 520 1 0.2 MidCentral 1,443 7 0.5 Hutt Valley 1,275 4 0.3 Capital & Coast 3,050 20 0.7 347 3 0.9 1,113 264 23.7 West Coast 265 1 0.4 Canterbury 4,851 847 17.5 458 189 41.3 2,492 30 1.2 43,796 4,106 9.4 Wairarapa Nelson Marlborough South Canterbury Southern Total 6 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 2 Screening uptake This section looks in more detail at screening uptake, breaking down the data into a range of more specific categories or data fields. 2.1 Antenatal HIV screening uptake by DHB Table 3 provides detailed information about antenatal HIV screening across DHBs. The table also covers the timing of antenatal HIV screening, to outline how the uptake rates were calculated. This analysis is important to provide transparent data and to understand its strengths and limitations. Please see section 1.6 for a description of how the estimated uptake rates were calculated for those DHBs showing rates in italics. Table 3: Screening uptake by DHB, 1 January to 30 June 2014 DHB of domicile Timing of antenatal HIV screen Option 1: First set of antenatal bloods with HIV testing Option 2: First set of antenatal bloods without HIV testing Option 3: AHIV testing outside first antenatal blood screening Aggregated data (N) All women screened (Options 1 + 2 + 3) (n) Women with Women with antenatal HIV screening with screening HIV (%) (Options (Uptake rate) 1 + 3) Northland 1049 110 15 1174 1064 Waitemata 4582 8 6 4596 4588 Auckland 4375 8 13 4396 4388 Counties Manukau 5244 5 1 5250 5245 Waikato 3983 5 0 3988 3983 99.9 Lakes 1036 3 1 1040 1037 99.7 Bay of Plenty 72* 85* 2010 1 0 2011 2010 100.0 Tairawhiti 494 1 4 499 498 99.8 Taranaki 864 234 17 1115 881 79.0 1158 4 2 1164 1160 99.7 Whanganui 492 88 7 587 499 85.0 MidCentral 1109 234 25 1368 1134 82.9 Hutt Valley 1120 284 19 1423 1139 80.0 Capital & Coast 2392 426 46 2864 2438 85.1 Wairarapa 291 48 4 343 295 86.0 Nelson Marlborough 859 2 0 861 859 76* West Coast 178 89 7 274 185 67.5 Canterbury 3710 168 30 3908 3740 78* Hawke’s Bay South Canterbury Southern Not recorded Total * 265 0 0 265 265 100.0 2454 3 1 2458 2455 59* 101 4111 0 4212 101 - 37,766 5832 198 43,796 37,964 86.7 Estimated uptake rates refer to section 1.6 page 5. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 7 The low uptake in the ‘not recorded’ field is skewed by the data collection limitations and therefore not reported. The vast majority of women in the ‘not recorded’ category did not have HIV testing but without an NHI number they could not be allocated to a DHB of domicile. This does not affect DHBs to which full NHI information was provided (see Table 2 in section 1.6) and has been taken into account when estimating the uptake rates for seven DHBs in this report; South Canterbury, Canterbury, Nelson Marlborough, Waitemata, Auckland, Counties Manukau and Northland. This data is included in the overall uptake rate of 87 percent. Screening uptake rates ranged from 100 percent to around 59 percent. Six DHBs had rates of 99 percent or more, the remaining DHBs, largely had rates between 68 percent and 86 percent (see Figure 2). Figure 2: Screening uptake by DHB, 1 January to 30 June 2014 * Estimated uptake rates. 2.2 Antenatal HIV screening uptake by requestor This subsection identifies the most regular requestors of antenatal HIV screening by uptake and also by DHB. Table 4 shows general practitioners (GPs) are the group that most commonly requests antenatal HIV screening, which is a finding consistent with past reports. There is little variation in uptake between the different types of requestors. The midwives have the highest uptake, similar to the last reporting period and in this report obstetricians have a slightly lower rate. ‘Other’ includes requests through family planning clinics, emergency departments, sexual health clinics and other hospital-based doctors. 8 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 Table 4: Screening uptake by requestor type, 1 January to 30 June 2014 Requestor Midwife GP Obstetrician Other Unknown Total n n N 11,810 23,430 868 605 1251 37,964 13,052 27,230 1052 688 1774 43,796 % uptake 90.5 86.0 82.5 87.9 70.5 86.7 = number of women who have had antenatal screens with HIV component only. N = total number of women who have had antenatal screens (with or without HIV component). Figure 3 shows this information graphically along with the average percentage for all women. Figure 3: Screening uptake by requestor type, 1 January to 30 June 2014 Table 5 shows the difference in uptake rates between DHBs, broken down by the different types of requestors. Uptake rates vary between individual DHBs though numbers in some categories are quite low. There are also differences within DHBs regarding the types of professionals that are requesting antenatal HIV screening. The differences are likely to be most interesting to individual DHBs seeking to understand uptake rates across requestors. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 9 Table 5: Screening uptake by DHB and requestor type, 1 January to 30 June 2014 DHB Requestor type Midwife n N Northland 470 510 Waitemata 1457 857 Auckland Counties Manukau 1248 Waikato GP Obstetrician n N 560 621 90.2 1458 99.9 2843 2849 860 99.7 3110 3113 1248 % 92.2 100.0 3780 n N % n N 8 15 53.3 2 99.8 15 16 93.8 99.9 28 30 99.9 1 99.8 Unknown % n N 4 50.0 24 24 100.0 1064 1174 6 6 100.0 267 267 100.0 4588 4596 93.3 7 7 100.0 386 386 100.0 4388 4396 2 50.0 3 3 100.0 213 213 100.0 5245 5250 36 36 100.0 116 87 87 100.0 3983 3988 100.0 n N % 72* 85* 1564 249 251 755 756 99.9 10 10 100.0 19 19 100.0 4 4 100.0 1037 1040 99.7 Bay of Plenty 777 777 100.0 1198 1198 100.0 16 17 94.1 16 16 100.0 3 3 100.0 2010 2011 100.0 Tairawhiti 197 197 100.0 299 299 100.0 1 2 50.0 1 1 100.0 0 0 0.0 498 499 99.8 Taranaki 437 538 81.2 314 422 74.4 32 57 56.1 96 96 100.0 2 2 100.0 881 1115 79.0 Hawke’s Bay 445 446 99.8 670 671 99.9 28 28 100.0 3 4 75.0 14 15 93.3 1160 1164 99.7 Whanganui 258 292 88.4 236 290 81.4 1 1 100.0 1 1 100.0 3 3 499 587 85.0 MidCentral 528 614 86.0 598 744 80.4 3 3 100.0 1 2 50.0 4 5 80.0 1134 1368 82.9 Hutt Valley 336 470 71.5 679 783 86.7 80 115 69.6 29 33 87.9 15 22 68.2 1139 1423 80.0 Capital & Coast 520 677 76.8 1724 1940 88.9 133 163 81.6 13 19 68.4 48 65 73.8 2438 2864 85.1 83 102 81.4 207 235 88.1 3 3 100.0 2 2 100.0 0 1 0.0 295 343 86.0 Nelson Marlborough 116 % 1563 99.2 2185 % Other Lakes Wairarapa 99.9 2181 3784 Total 100.0 99.9 325 326 99.7 460 460 100.0 25 25 100.0 46 46 100.0 3 4 75.0 859 861 76* West Coast 8 8 100.0 10 12 83.3 3 3 100.0 1 1 100.0 163 250 65.2 185 274 67.5 Canterbury 1062 1138 93.3 2299 63.6 3740 41 41 914 916 35 619 South Canterbury Southern Not recorded Total 11,810 13,052 2366 97.2 288 301 95.7 84 92 91.3 7 11 3908 78* 162 162 100.0 25 25 100.0 35 35 100.0 2 2 100.0 265 265 59* 99.8 1291 1292 99.9 125 125 100.0 122 122 100.0 3 3 100.0 2455 2458 99.9 3048 1.8 7 75 9.3 2 63 3.2 3 407 86.0 868 1,052 82.5 605 688 87.9 1,251 1,774 100.0 5.7 54 90.5 23,430 27,230 n = number of women who have had antenatal screens with HIV component only. N = total number of women who have had antenatal screens (with or without HIV component). * 10 Estimated uptake rates refer to section 1.6 page 5. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 0.7 101 70.5 37,964 4212 43,796 86.7 2.3 Antenatal HIV screening uptake by age group Antenatal HIV screening is available to all pregnant women. The results below explore the variation in uptake rates by age. At the national level, Table 6 and Figure 4 indicate that there is little difference in antenatal HIV screening uptake rate by age group except for a small drop off in the over 40 year age group. Table 7 breaks down this data by DHB. While rates appear higher in under 15 year olds the numbers are quite small. Table 6: Screening uptake by age group, 1 January to 30 June 2014 Age group n N Under 15 years 54 60 90.0 15–19 years 2765 3142 88.0 20–24 years 7457 8464 88.1 25–29 years 10,084 11,605 86.9 30–39 years 15,888 18,453 86.1 1710 2065 82.8 6 7 37,964 43,796 40+ years Not recorded Total n % uptake 86.7 = number of women who have had antenatal screens with HIV component only. N = total number of women who have had antenatal screens (with or without HIV component). Figure 4: Screening uptake by age group, 1 January to 30 June 2014 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 11 Table 7: Screening uptake by DHB and age group, 1 January to 30 June 2014 DHB Age group (years) <15 n N 15–19 % n N 20–24 25–29 % n N % n N 30–39 % All ages (excluding missing age) 40+ n N % n N 347 384 90.4 43 % n** N** 87.8 1064 1174 Northland 7 7 100.0 103 117 88.0 293 322 91.0 271 295 Waitemata 3 3 100.0 216 216 100.0 642 644 99.7 1170 1173 99.7 2308 2311 99.9 248 248 100.0 4587 4595 Auckland 2 2 100.0 192 192 100.0 616 617 99.8 1107 1109 99.8 2265 2269 99.8 205 206 99.5 4387 4395 100.0 1188 1191 99.7 1464 1465 99.9 1905 1906 99.9 207 207 100.0 5245 5250 99.8 1122 1122 100.0 1405 1407 99.9 155 155 100.0 3983 3988 Counties Manukau 91.9 49 % 72* 85* 10 10 100.0 471 471 Waikato 5 5 100.0 351 352 99.7 945 947 Lakes 2 2 100.0 103 103 100.0 274 275 99.6 288 289 99.7 336 337 99.7 34 34 100.0 1037 1040 99.7 Bay of Plenty 2 2 100.0 196 196 100.0 435 435 100.0 546 546 100.0 747 748 99.9 84 84 100.0 2010 2011 100.0 Tairawhiti 3 3 100.0 54 54 100.0 111 112 99.1 139 139 100.0 173 173 100.0 18 18 100.0 498 499 99.8 Taranaki 3 3 100.0 74 87 85.1 198 239 82.8 275 334 82.3 301 410 73.4 30 42 71.4 881 1115 79.0 Hawke’s Bay 1 1 100.0 118 118 100.0 265 266 99.6 289 289 100.0 441 443 99.5 46 47 97.9 1160 1164 99.7 Whanganui 2 3 66.7 59 62 95.2 146 164 89.0 129 161 80.1 143 175 81.7 20 22 90.9 499 587 85.0 MidCentral 1 1 100.0 107 121 88.4 266 318 83.6 317 396 80.1 407 481 84.6 35 50 70.0 1133 1367 82.9 Hutt Valley 0 1 0.0 98 115 85.2 243 294 82.7 278 347 80.1 463 590 78.5 57 76 75.0 1139 1423 80.0 Capital & Coast 4 5 80.0 126 143 88.1 371 440 84.3 598 694 86.2 1207 1422 84.9 132 160 82.5 2438 2864 85.1 Wairarapa 1 1 100.0 36 40 90.0 75 86 87.2 78 91 85.7 92 109 84.4 13 16 81.3 295 343 86.0 Nelson Marlborough 1 1 100.0 70 70 100.0 161 162 99.4 225 225 100.0 363 363 100.0 38 39 97.4 858 860 76* West Coast 2 2 100.0 15 23 65.2 42 62 67.7 52 73 71.2 64 101 63.4 10 13 76.9 185 274 67.5 Canterbury 5 6 83.3 198 215 92.1 647 677 95.6 976 1022 95.5 1715 207 95.7 3739 South Canterbury 0 0 0.0 17 17 100.0 49 49 100.0 78 78 Southern 0 0 0.0 152 152 100.0 470 472 99.6 658 658 Not recorded 0 2 0.0 9 278 3.2 20 692 2.9 24 1,099 54 60 Total 90.0 2,765 3,142 88.0 7,457 8,464 88.1 10,084 11,605 1780 96.3 198 109 109 100.0 12 100.0 1055 1056 99.9 119 1,879 2.2 6 100.0 2.2 42 86.9 15,888 18,453 99.9 3907 78* 265 265 59* 119 100.0 2454 2457 99.9 261 4211 12 100.0 86.1 1,710 2,065 2.3 101 82.8 37,958 43,789 86.7 n = number of women who have had antenatal screens with HIV component only. N = total number of women who have had antenatal screens (with or without HIV component). * 12 Estimated uptake rate refer to section 1.6 page 5. ** In order to show all age groups the table excludes data for seven women (six of whom had AHIV testing) who did not have a valid date of birth; this does not affect the overall percentages. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 2.4 Antenatal HIV screening uptake by ethnicity Ethnicity data in this report is grouped according to a prioritised system, which is commonly applied across the New Zealand health sector. Prioritisation involves allocating each person to a single ethnic group, based on the ethnicities that person has identified, in the prioritised order of Māori, Pacific, Asian and Other ethnicity (and Not stated / Unknown). For example, if someone identifies as being New Zealand European and Māori, under the prioritised ethnicity method, they are classified as Māori for the purpose of the analysis. Under this method, the group Other ethnicity effectively refers to non-Māori, non-Pacific, non-Asian people. At a national level, Table 8 and Figure 5 show a slightly higher uptake rate in this reporting period for Pacific and Asian women. While the difference is not large, this trend is consistent with previous reports. Table 8: Screening uptake by ethnicity, 1 January to 30 June 2014 Ethnicity n N % Māori 7420 7806 95.1 Pacific 3700 3793 97.5 Asian 6171 6347 97.2 19,884 20,931 95.0 789 4919 37,964 43,796 Other ethnicity Not recorded Total n 86.7 = number of women who have had antenatal screens with HIV component only. N = total number of women who have had antenatal screens (with or without HIV component). Figure 5: Screening uptake by ethnicity, 1 January to 30 June 2014 As Table 9 shows, rates across DHBs do not vary greatly between ethnic groups though rates do vary between DHBs as for the data broken down by requestor type and age group (Tables 5 and 7). Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 13 Table 9: Screening uptake by DHB and ethnicity, 1 January to 30 June 2014 DHB Ethnicity Māori N % n N % 563 88.1 21 22 95.5 44 49 89.8 500 502 99.6 423 424 99.8 1245 380 381 99.7 686 688 Counties Manukau 1078 1080 99.8 1581 1581 Waikato Auckland 496 Other ethnicity n Waitemata N Asian % Northland n Pacific All ethnicities n N 492 1246 99.7 1434 100.0 1233 Not recorded % n N % n N % 528 93.2 11 12 91.7 1064 1174 99.9 2339 2343 99.8 81 81 100.0 4588 4596 1435 99.9 1796 1799 99.8 92 93 98.9 4388 4396 1234 99.9 1279 1281 99.8 74 74 100.0 5245 5250 99.7 2142 2144 99.9 163 163 100.0 3983 3988 99.9 464 466 99.6 12 12 100.0 1037 1040 99.7 100.0 1106 1107 99.9 33 33 100.0 2010 2011 100.0 72* 85* 1141 1143 99.8 155 155 100.0 382 383 Lakes 463 464 99.8 23 23 100.0 75 75 Bay of Plenty 674 674 100.0 46 46 100.0 151 151 Tairawhiti 287 288 99.7 17 17 100.0 12 12 100.0 179 179 100.0 3 3 100.0 498 499 99.8 Taranaki 179 231 77.5 12 12 100.0 60 74 81.1 611 772 79.1 19 26 73.1 881 1115 79.0 Hawke’s Bay 383 384 99.7 56 56 100.0 65 65 100.0 646 649 99.5 10 10 100.0 1160 1164 99.7 Whanganui 194 226 85.8 17 22 77.3 20 22 90.9 265 314 84.4 3 3 499 587 85.0 MidCentral 256 315 81.3 52 61 85.2 96 113 85.0 684 827 82.7 46 52 88.5 1134 1368 82.9 Hutt Valley 276 349 79.1 106 125 84.8 152 194 78.4 587 735 79.9 18 20 90.0 1139 1423 80.0 Capital & Coast 304 348 87.4 235 279 84.2 440 504 87.3 1410 1678 84.0 49 55 89.1 2438 2864 85.1 70 83 84.3 3 5 60.0 13 13 100.0 201 234 85.9 8 8 100.0 295 343 86.0 Wairarapa Nelson Marlborough 100.0 100.0 110 111 99.1 22 22 100.0 53 53 100.0 666 667 99.9 8 8 100.0 859 861 76* West Coast 25 38 65.8 3 5 60.0 11 14 78.6 146 217 67.3 0 0 0.0 185 274 67.5 Canterbury 312 334 93.4 158 165 95.8 487 512 95.1 2713 2826 96.0 70 71 98.6 3740 3908 78* 23 23 100.0 3 3 100.0 14 14 219 219 100.0 6 6 265 265 59* 247 247 100.0 77 77 100.0 173 173 100.0 1878 1881 99.8 80 80 100.0 2455 2458 99.9 22 22 100.0 4 5 80.0 11 11 65 93.8 3 4,109 7,420 7,806 95.1 3,700 3,793 97.5 6,171 6,347 95.0 789 4,919 South Canterbury Southern Not recorded Total n 100.0 61 97.2 19,884 20,931 100.0 0.1 101 16.0 37,964 4212 43,796 = number of women who have had antenatal screens with HIV component only. N = number of women who have had antenatal screens (with or without HIV component). 14 100.0 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 * Estimated uptake rates refer to section 1.6 page 5. 86.7 2.5 Antenatal HIV screening uptake by NZDep The NZDep2006 Index of Deprivation combines nine variables from the 2006 census which reflect eight dimensions of socioeconomic deprivation. It comprises a 10-category ordinal scale that ranges from 1 (assigned to the 10 percent of areas with the least deprived NZDep2006 scores) to 10 (assigned to the 10 percent of areas with the most deprived NZDep2006 scores). The NZDep2006 deprivation scores apply to areas rather than to individual people (Salmond et al 2007). At a national level, there is little difference in uptake rates by decile grouping, as shown in Table 10 and Figure 6. The reason why some women do not have a decile rating is almost always because their records were missing an NHI number; in almost all of these cases, the women did not have an antenatal HIV test with their first antenatal bloods and hence the uptake rate is low. Table 11 shows the data by DHB. Table 10: Screening uptake by NZDep2006 decile, 1 January to 30 June 2014 Decile n N % uptake 1–2 5314 5592 95.0 3–4 5668 5882 96.4 5–6 7117 7442 95.6 7–8 8825 9261 95.3 10,929 11,397 95.9 111 4222 37,964 43,796 9–10 Not recorded Total n 86.7 = number of women who have had antenatal screens with HIV component only. N = total number of women who have had antenatal screens (with or without HIV component). Figure 6: Screening uptake by NZDep2006 decile, 1 January to 30 June 2014 As with the previous categories broken down by DHB, the major variation is across DHBs rather than across decile groups, and for many DHBs the actual numbers involved are quite small. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 15 Table 11: Screening uptake by DHB and NZDep2006 decile, 1 January to 30 June 2014 DHB Decile 1–2 n N 3–4 % n N All deciles 5–6 7–8 9–10 Unknown % n N % n N % n N % n N % n N 97.8 186 199 93.5 313 339 92.3 432 499 86.6 0 0 0.0 1064 1174 1035 99.9 1383 1387 99.7 342 343 99.7 1 1 100.0 4588 4596 Northland 45 47 95.7 88 Waitemata 884 886 99.8 944 944 100.0 1034 Auckland 475 475 100.0 751 752 99.9 957 959 99.8 868 871 99.7 1335 1337 99.9 2 2 100.0 4388 4396 Counties Manukau 645 645 100.0 351 352 99.7 676 676 100.0 491 491 100.0 3082 3086 99.9 0 0 0.0 5245 5250 Waikato 453 454 371 371 100.0 754 754 100.0 1184 1187 1222 99.9 0 0 0.0 3983 3988 Lakes 88 100.0 99.8 90 120 120 100.0 88 Bay of Plenty 48 48 100.0 364 Tairawhiti 25 25 100.0 44 Taranaki 73 92 79.3 77 100 77.0 227 299 75.9 377 459 114 100.0 184 185 99.5 137 138 99.3 Hawke’s Bay Whanganui 114 99.7 1221 % 72* 85* 99.9 177 178 99.4 185 185 100.0 467 469 99.6 0 0 0.0 1037 1040 99.7 99.7 472 472 100.0 582 582 100.0 544 544 100.0 0 0 0.0 2010 2011 100.0 44 100.0 62 62 100.0 19 19 100.0 348 349 99.7 0 0 0.0 498 499 99.8 82.1 126 164 76.8 1 1 100.0 881 1115 79.0 297 297 100.0 428 430 99.5 0 0 0.0 1160 1164 99.7 365 34 40 85.0 54 61 88.5 47 61 77.0 156 185 84.3 208 240 86.7 0 0 0.0 499 587 85.0 MidCentral 92 106 86.8 156 180 86.7 257 299 86.0 291 355 82.0 338 428 79.0 0 0 0.0 1134 1368 82.9 Hutt Valley 202 265 76.2 67 85 78.8 174 217 80.2 411 522 78.7 285 334 85.3 0 0 0.0 1139 1423 80.0 Capital & Coast 709 833 85.1 406 487 83.4 572 666 85.9 182 200 91.0 569 678 83.9 0 0 0.0 2438 2864 85.1 Wairarapa 29 35 82.9 43 49 87.8 28 33 84.8 144 163 88.3 50 62 80.6 1 1 100.0 295 343 86.0 Nelson Marlborough 70 70 100.0 248 250 99.2 184 184 100.0 287 287 100.0 70 70 100.0 0 0 0.0 859 861 76* West Coast 15 22 68.2 15 35 42.9 36 50 72.0 72.7 0 0 0.0 185 274 67.5 Canterbury 765 799 793 96.7 601 624 96.3 64 100.0 66 66 100.0 95 470 100.0 556 557 0 0 South Canterbury Southern Not recorded Total 95.7 767 27 27 100.0 64 489 489 100.0 586 587 99.8 470 0 0 0.0 0 0 95.0 5668 5882 96.4 7117 7442 0 0 5314 5592 0.0 0.0 55 79 69.6 64 88 949 1001 94.8 658 691 95.2 0 0 0.0 3740 3908 78* 95 100.0 13 13 100.0 0 0 0.0 265 265 59* 99.8 349 350 99.7 5 5 100.0 2455 2458 99.9 0.0 0 0 101 4212 - 95.6 8825 9261 n = number of women who have had antenatal screens with HIV component only. N = total number of women who have had antenatal screens (with or without HIV component). * 16 Estimated uptake rates refer to section 1.6 page 5. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 95.3 10,929 11,397 0.0 101 4212 95.9 111 4222 2.4 2.6 37,964 43,796 86.7 3 Initial reactive and confirmed positive results This section reports aggregate information on reactive EIA tests and confirmed HIV cases, rather than data at DHB level, due to the small number of women involved. Aggregate reporting ensures this information is not identifiable. Information is reported on reactive EIA screening tests and on confirmed HIV positive cases, identified through both the Antenatal HIV Screening Programme and through routine AEG surveillance. As indicated in Table 12, there were no confirmed HIV positive cases identified through screening and this matches the number identified through AEG surveillance. Table 12: Initial reactive screening test results and confirmed HIV positive results, 1 January to 30 June 2014 Number of reactive EIA screening tests Total 11 Number of confirmed HIV positive cases Identified through screening Identified in the antenatal period through AEG surveillance 0 0 3.1 Reactive EIA screening tests results If the initial EIA screening test result is reactive, then the screening programme algorithm requires that a second sample is collected for confirmatory testing. A reactive result would be a cause for concern to the woman, and it is important to monitor these numbers to make sure they remain low. For this six-month period there were 11 reactive test results from ten DHBs. This total is lower than recent reports but is consistent with screening earlier periods and is well below initial programme predictions that 1 in 1000 women, or 0.1 percent, would have a reactive result. 3.2 Confirmed HIV positive cases There were no HIV positive cases identified in this six-month period. This is the same as the information found though quarterly reporting from the AIDS Epidemiology Group (AEG 2014b). Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 17 References AEG, 2014a. AIDs in NZ, issue 73, June 2014. University of Otago. AEG. 2014b. One hundred and two Quarterly Report of the AIDS Epidemiology Group (AEG) to the Ministry of Health. August 2014. University of Otago. Centers for Disease Control and Prevention. 2007. Mother to child (perinatal) transmission and prevention. CDC HIV/AIDS Fact Sheet October: 1–5. Dickson N, Paul C, Wilkinson L, et al. 2002. Estimates of HIV prevalence among pregnant women in New Zealand. New Zealand Public Health Report 9(3): 17–24. Health and Disability Commissioner. 2005. A Report by the Health and Disability Commissioner (Case 04HDC14171). McAllister S, Lovell S, Dickson N. 2013. The impact of repeat testing in the New Zealand antenatal HIV screening programme: a qualitative study. Journal of Medical Screening 20(1): 1–6. National Health Committee. 2004. HIV Screening in Pregnancy: A Report to the New Zealand Minister of Health. Wellington: Ministry of Health. National Screening Unit. 2008. Guidelines for Maternity Providers offering antenatal HIV screening in New Zealand: The New Zealand Universal Offer Antenatal Human Immunodeficiency Virus (HIV). Wellington: Ministry of Health. Rongkavilit C, Asmar BI. 2004. Advances in prevention of mother-to-child HIV transmission. Indian Journal of Paediatrics 1(71): 69–79. Salmond C, Crampton P, Atkinson J. 2007. NZDep2006 Index of Deprivation. Wellington: Department of Public Health, University of Otago. UNAIDS, 2013. GAP report 2013. UNAIDs, Geneva. Ziegler JB, Graves N. 2004. The time to recommend antenatal HIV screening for all pregnant women has arrived. Medical Journal Australia 181(3): 124–5. 18 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 Appendix 1: History of data collection and reporting processes Initial data process from 20 March 2006 to 30 June 2008 Up until the end of quarter 2 of 2008, Waikato DHB extracted data from its laboratory system, which included name and NHI number. This data was sent to the New Zealand Health Information Service (NZHIS) to validate it and link the NHI number to ethnicity, domicile code and NZDep01 decile. Due to difficulties and delays reported by NZHIS in linking the NHI data, this reporting method was abandoned as new DHBs started to enrol in the programme. Waikato DHB then converted to an intermediate system (outlined below) and, as new DHBs came on board, they used that intermediate system too. Intermediate data process from 1 July 2008 to 31 March 2010 In the intermediate system, antenatal screening data to be collected by the DHBs included Date of Birth, Screen Requestor Type, DHB Code, Screen Type, Screen Result, Service Date (Date sample received), Ethnicity Code, Domicile Code, and – where required – Confirmatory Testing Date, Confirmatory Testing Result, and Comments. This data collection did not personally identify participants. Using email, files were made available to the AIDS Epidemiology Group (AEG) for processing and reporting. Current data process from 1 April 2010 Currently, using a secure file transfer process (FTP), data is sent quarterly from DHBs to National Collections of the Ministry of Health. The data is pre-validated, amalgamated into a single file, and (based on NHI information) enriched with gender, ethnicity and domicile code. The data is then de-identified by National Collections, and sent using a secure FTP to the NSU. The NSU runs further checks. Based on this quantitative information, the NSU’s Monitoring and Evaluation team, in collaboration with the Antenatal and Newborn Screening team, produces a draft monitoring report. The Programme’s Advisory Group then reviews the draft report and makes recommendations on areas for the team to review. DHBs’ feedback is sought before the report is finalised. The final monitoring reports are published. No information is or will be published that could potentially identify individuals. The data quality process resulted in a number of quality improvements. These improvements were made to ensure that: the data set is as complete as possible the data set includes one record per woman only the data set contains records only for the reporting period records include all data deemed essential for reporting. All demographic data is retrieved from National Health Index Register. Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 19 Appendix 2: Selected data fields and descriptions The table below shows the key spreadsheet data requested from DHBs and used to calculate the information in this report. Field Description DHB code Your regional DHB code NHI number NHI number of the participant (must be taken from the laboratory screening form) Date of birth (DoB) Date of birth of the participant (must be taken from the laboratory screening form) Screen requestor type Options are: 1 = Midwife 2 = GP 3 = Obstetrician 4 = Other 5 = Unknown Date initial sample collected Date the initial blood sample was collected (taken) Screen result Repeatedly reactive EIA is reported as reactive EIA; result reported as non-reactive EIA otherwise. No Western Blot results are to be included in this column. If the screened person has had HIV testing, the options are: 1 = Non-reactive EIA 2 = Reactive EIA Timing of (initial) AHIV screen When an antenatal HIV screening test was requested, options are: 1 = First set of antenatal bloods with HIV testing 2 = First set of antenatal bloods without HIV testing 3 = AHIV testing outside first antenatal blood screening. Option 1: An antenatal HIV test result is received with other first antenatal blood results. This includes results of AHIV tests when taken in conjunction with the first antenatal screen: This means that the woman had: Group and Antibodies, rubella, RPR/VDRL, Hep B, FBC, AHIV (unless she has declined any one of the group of tests other than HIV). Option 2: No antenatal HIV test result is received but other antenatal blood results are received. This means she had the first antenatal screen but not the AHIV. The woman had: Group and Antibodies, rubella, RPR/VDRL, Hep B, FBC. Option 3: Antenatal HIV result is received but no other antenatal blood results are received – this test has been done during pregnancy (AHIV) and it was not done with the first antenatal bloods. This includes results of AHIV tests which were performed without the first antenatal blood screen the woman may have had: AHIV alone or she may have had: AHIV along with a subsequent (28- or 36-week) antenatal screen. The subsequent screen includes only Group and Antibodies and FBC and is sometimes carried out with other tests such as the polycose screen. (If the antenatal screen includes the serology (rubella, RPR/VDRL, Hep B), it is the first antenatal screen and will fit with either option 1 or 2.) Date confirmed sample received Note that confirmatory testing within the Antenatal HIV Screening Programme only pertains to NAAT/ PCR-RNA results. No Western Blot results are to be included in this column. If the screened person has had confirmatory HIV testing then please enter here the date the confirmatory blood sample has been received for confirmatory testing. Confirmatory test result Note that confirmatory testing within the Antenatal HIV Screening Programme only pertains to NAAT/ PCR-RNA results. No Western Blot results are to be included in this column. The options are: 1 = Negative 2 = Positive 20 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 Antenatal HIV Screening Programme: Monitoring Report 1 January to 30 June 2014 21
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