Sevoflurane Selectively Increases Coronary Collateral Blood Flow Independent of KATPChannels In Vivo
Anesthes. 1999;90(1):246-256.
Figure Legend:
Figure 6. Experimental preparation illustrating the left anterior descending coronary artery (LAD) occlusion produced with an
ameroid constrictor and the position of the LAD retrograde flow (RF) cannula used to measure large coronary collateral blood flow.
Coronary collateral conductance was calculated assuming that proximal left circumflex coronary artery (LCCA) perfusion pressure
(P1) was equivalent to aortic pressure and that the proximal LCCA offered no resistance to flow such that P 1was equal to collateral
perfusion pressure (P2). Increases in large collateral conductance (C1) occurred in response to sevoflurane (SEV) but not nicorandil
(NIC).
and nicorandil increased
the
small collaterals
(schematically
illustrated)
Date ofSevoflurane
download: 7/31/2017
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© conductance
2017 AmericanofSociety
of Anesthesiologists.
All rights
reserved.or the collateral2
dependent bed, denoted collectively as C . Nicorandil primarily caused increases in normal zone LCCA conductance (C3), whereas