G
O
ID
G
O:
00
05
62
2
Enri
pch
v
me
al
nt
u
Sco
e
re
GO NAME
GO
Cat
ego
ry
intracellular
FZD6,MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1
,RAB3GAP2,PLEKHA3,PBX2,LPP,DHX34,KANK2,CRIP2,ACADVL,EIF2
B4,GTF3C2,CADM1,RAI1,PSMB10,XRN1,CKB,CLMN,IGF1R,AVL9,LAM
B1,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,MY
NN,TRNAU1AP,RAI14,NOC2L,PPIL2,TARS,RAF1,NLRP1,ZNF131,SEP
T5,TSTD1,LEPRE1,SLC16A3,PPP1R13B,GAS8,COL9A1,RSC1A1,SFS
WAP,CDK13,RBM6,BDNF,TAZ,SIN3B,SPOP,CPE,CBX5,PLCD1,SART1
,COL2A1,LRRC1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,GBP3,SHMT2,Z
FP91,CNTF,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLN
cell
S1A,NUP98,EED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,MCF2L,USP4,PP 1.17
ular
FIBP2,HDAC6,GLG1,ARHGEF12,EHMT1,ATP6V1D,VRK2,DYNC1I1,RN 492
_co
H1,ZNF496,HGS,CASP4,DERL2,IL15RA,NARS,LANCL2,H6PD,SYTL4,D 724
mpo
GKA,TTLL3,ARPC4-TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,HLA2
nent
C,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,YIPF1,ADAMTS1,RGL4,
BCL2L13,BCL2L11,RBPMS,XYLT1,GLOD4,STARD13,ZSCAN31,STARD
9,XBP1,COG4,CPM,FDPS,NISCH,PAM,ABCC1,NOM1,CEP135,GLT8D1
,SNRNP70,HSD17B12,DDX23,HLADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,MARK4,UHMK1,USP4
7,ADAM8,MAP7D1,NOL3,POLR3E,CAPZB,GABPB1,PRPF40A,DNAJC1
0,RNF220,RAB35,XAF1,CD9,CDC37L1,PCGF6,RANBP1,SIPA1L1,MAR
CH6,DDX39A,KRIT1,KPNA6,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTP
N6,SUGP1,EEF1A1,ACTR3,LHX4,VASP,CMIP,CSNK2A1,IGBP1,UPF3A
,NOD1,PRKACA,STAT2,ANAPC4,RPP14,DHX9,PIGS,PLK1,SDCCAG8,
ZNF446,PNPO,VPS52,LMAN2,PDE7B,PREPL,ASNS,TBC1D2B,COL16
Symbols within list
1.
6
6
E
3
1
A1,ECHDC1,NUTF2,TTC19,DNM1L,TXNL1,PTGES2,UPF1,ZNF621,HD
GF,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1,SHISA5,CCNL1,RHOBTB1
,HERC2,CHD6,ZC3H12A,NUP210,TBC1D10B,SEPT4,MIB2,POLM,SLC1
1A2,DIP2A,SYMPK,EFTUD2,AAMP,RAB24,ATG4B,CNP,CLN8,TBX18,P
IGN,GCDH,LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,ZNF7
21,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,DNPEP,TBC1D
14,GALK2,PRPF3,TNK2,ENGASE,COL14A1,USP20,GIT2,FLG,DCAF11,
WAC,STK11IP,STK4,ZNF142,FUBP3,TRO,MTG1,CCDC14,RARS,ZNF5
40,SIKE1,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR1,HPS4,RAB18,HSF
4,PAIP1,CAPRIN1,GTF3C1,MMP16,NADSYN1,PMS1,ADCY4,CELF1,S
NCAIP,PDE4D,AFAP1,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,PL
EKHG4,SHARPIN,DPF2,TCHP,CPT1B,CHKB,NADK,IDI1,RNF8,CDYL2,
RUSC2,KIAA0586,CYP2R1,SEC31A,MDM2,KCMF1,RHBDD1,SNAP23,
COL12A1,FKBP1A,ZFYVE26,PRKCH,DAZAP1,ANAPC16,PPM1F,ZNF5
95,TBP,DIS3L,IDH3G,YY1,FAM13A,TLN2,INO80,GPAT2,GMEB2,SSH2,
THBS3,MCFD2,PFDN5,TTC1,CREB1,TRAF3IP1,SRP9,RALGPS2,FLII,T
NFRSF25,PLEKHG5,QSOX1,RPRD1A,CCNDBP1,DDX58,ALDH6A1,RP
L27,LCP2,CCNL2,PTPRK,SNX13,DFNA5,AP4B1,RHBDF1,SERPINH1,M
AGI1,SNX21,NF1,ZEB1,PIH1D1,ACAA1,NEK3,EIF4B,CRIP1,SERBP1,S
ETBP1,SPATS2,NUB1,IFITM3,EMC3,ATG12,NUMA1,TPM4,RGMB,COL
18A1,RTKN,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,ZNF3,RPS6KA5,
G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,CAPN10,DCAF8,
GCNT2,ZNF837,PKD2,CASP2,STRN4,HNRNPA3,RXRB,GALT,UBAC1,
LMNA,NUDT6,RSL1D1,MITF,NOL8,PPP2R3C,RB1,GOLGA8B,GOLGA8
A,PRMT5,HMGXB3,MAPK8IP3,GNAI1,USP3,PLEKHA2,STX16,DHRS1,
MZF1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,RNF168,PAFAH1B1,
ZNF865,LYRM2,SENP2,ISYNA1,EDEM2,GPCPD1,IL18,RPS19BP1,PU
M2,MTCH1,SLFN11,CALCOCO2,STARD3,TPP1,SYTL2,DNALI1,SUB1,
PWP2,CHMP1A,PDE8A,NSA2,AACS,ARPC2,SYNE1,STK38L,EPN2,DD
X6,ZNF558,ANXA5,GALNT2,ADAM15,SH3BP5,MUM1,USP33,ZNF263,Z
NF180,BICD1,NTMT1,ZNF276,RGS3,GCC2,NR1H3
G
O:
00
44
42
4
intracellular part
FZD6,MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1
,RAB3GAP2,PLEKHA3,PBX2,LPP,KANK2,CRIP2,ACADVL,EIF2B4,GTF
3C2,CADM1,RAI1,PSMB10,XRN1,CKB,CLMN,IGF1R,AVL9,LAMB1,NPH
P3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,MYNN,TRN
AU1AP,RAI14,NOC2L,PPIL2,TARS,RAF1,NLRP1,ZNF131,SEPT5,TSTD
1,LEPRE1,SLC16A3,PPP1R13B,GAS8,COL9A1,RSC1A1,SFSWAP,CDK
13,RBM6,BDNF,TAZ,SIN3B,SPOP,CPE,CBX5,PLCD1,SART1,COL2A1,
LRRC1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,GBP3,SHMT2,Z
FP91,CNTF,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLN
S1A,NUP98,EED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,MCF2L,USP4,H
DAC6,GLG1,ARHGEF12,EHMT1,ATP6V1D,VRK2,DYNC1I1,RNH1,ZNF
496,HGS,DERL2,IL15RA,NARS,LANCL2,H6PD,SYTL4,DGKA,TTLL3,AR
cell
PC4-TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,HLAular
C,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,YIPF1,ADAMTS1,RGL4,
_co
BCL2L13,BCL2L11,RBPMS,XYLT1,GLOD4,STARD13,ZSCAN31,STARD
mpo
9,XBP1,COG4,CPM,FDPS,NISCH,PAM,ABCC1,NOM1,CEP135,GLT8D1
nent
,SNRNP70,HSD17B12,DDX23,HLADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,MARK4,UHMK1,USP4
7,ADAM8,MAP7D1,NOL3,POLR3E,CAPZB,GABPB1,PRPF40A,DNAJC1
0,RNF220,RAB35,XAF1,CD9,CDC37L1,PCGF6,RANBP1,SIPA1L1,MAR
CH6,DDX39A,KRIT1,KPNA6,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTP
N6,SUGP1,EEF1A1,ACTR3,LHX4,VASP,CMIP,CSNK2A1,IGBP1,UPF3A
,NOD1,PRKACA,STAT2,ANAPC4,RPP14,DHX9,PIGS,PLK1,SDCCAG8,
ZNF446,PNPO,VPS52,LMAN2,PDE7B,PREPL,ASNS,COL16A1,ECHDC
1,NUTF2,TTC19,DNM1L,TXNL1,PTGES2,UPF1,ZNF621,HDGF,FDXR,R
C3H1,PPP5C,PIGG,PDXK,NPC1,SHISA5,CCNL1,RHOBTB1,HERC2,CH
D6,ZC3H12A,NUP210,TBC1D10B,SEPT4,MIB2,POLM,SLC11A2,DIP2A,
SYMPK,EFTUD2,AAMP,RAB24,ATG4B,CNP,CLN8,TBX18,PIGN,GCDH,
LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,ZNF721,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,DNPEP,TBC1D
1.17
917
472
2
2.
8
5
E
3
0
G
O:
00
05
73
7
cytoplasm
14,GALK2,PRPF3,TNK2,ENGASE,COL14A1,USP20,GIT2,FLG,DCAF11,
WAC,STK11IP,STK4,ZNF142,FUBP3,TRO,MTG1,CCDC14,RARS,ZNF5
40,SIKE1,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR1,HPS4,HSF4,PAIP
1,CAPRIN1,GTF3C1,MMP16,NADSYN1,PMS1,ADCY4,CELF1,SNCAIP,
PDE4D,AFAP1,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,SHARPIN,
DPF2,TCHP,CPT1B,CHKB,NADK,IDI1,RNF8,CDYL2,RUSC2,KIAA0586,
CYP2R1,SEC31A,MDM2,RHBDD1,SNAP23,COL12A1,FKBP1A,ZFYVE2
6,PRKCH,DAZAP1,ANAPC16,PPM1F,ZNF595,TBP,DIS3L,IDH3G,YY1,F
AM13A,TLN2,INO80,GPAT2,GMEB2,SSH2,THBS3,MCFD2,PFDN5,TTC
1,CREB1,TRAF3IP1,SRP9,RALGPS2,FLII,TNFRSF25,PLEKHG5,QSOX
1,RPRD1A,CCNDBP1,DDX58,ALDH6A1,RPL27,LCP2,CCNL2,PTPRK,S
NX13,DFNA5,AP4B1,RHBDF1,SERPINH1,MAGI1,SNX21,NF1,ZEB1,PI
H1D1,ACAA1,NEK3,EIF4B,CRIP1,SERBP1,SETBP1,SPATS2,NUB1,IFI
TM3,EMC3,ATG12,NUMA1,TPM4,RGMB,COL18A1,EBF1,RPL9,MED28,
PHF15,FKBP10,UNKL,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,
ADSL,ALG6,ST3GAL4,CAPN10,DCAF8,GCNT2,ZNF837,PKD2,CASP2,
STRN4,HNRNPA3,RXRB,GALT,UBAC1,LMNA,NUDT6,RSL1D1,MITF,N
OL8,PPP2R3C,RB1,GOLGA8B,GOLGA8A,PRMT5,HMGXB3,MAPK8IP3,
GNAI1,USP3,PLEKHA2,STX16,DHRS1,MZF1,ZFPM2,TP53BP1,BLOC1
S5,TXNDC5,NEXN,RNF168,PAFAH1B1,ZNF865,LYRM2,SENP2,ISYNA
1,EDEM2,GPCPD1,IL18,RPS19BP1,PUM2,MTCH1,SLFN11,CALCOCO
2,STARD3,TPP1,SYTL2,DNALI1,SUB1,PWP2,CHMP1A,PDE8A,NSA2,A
ACS,ARPC2,SYNE1,STK38L,EPN2,DDX6,ZNF558,ANXA5,GALNT2,AD
AM15,SH3BP5,MUM1,USP33,ZNF263,ZNF180,BICD1,NTMT1,ZNF276,
RGS3,GCC2,NR1H3,GARS,CYTH2,CCDC115,GRB10,MRPS7,PLK2,PA
N2,HEXA
FZD6,MARVELD1,CDK14,USP10,SLC25A37,CRBN,RAB3GAP2,PLEKH
cell
A3,LPP,KANK2,CRIP2,ACADVL,EIF2B4,CADM1,RAI1,PSMB10,XRN1,C
ular
KB,CLMN,AVL9,LAMB1,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,RA
_co
LGAPA2,TRNAU1AP,RAI14,PPIL2,TARS,RAF1,NLRP1,SEPT5,TSTD1,L
mpo
EPRE1,PPP1R13B,GAS8,COL9A1,RSC1A1,BDNF,TAZ,SIN3B,CPE,CB
nent
X5,PLCD1,SART1,COL2A1,LRRC1,CCDC91,RAB34,RILPL1,HLA-
1.24
266
834
7
1.
3
4
E
2
DPB1,ST3GAL1,MARCH5,UBXN1,DPP4,FBXO32,CMPK2,ENOSF1,PTP
N22,MMS19,GBP3,SHMT2,CNTF,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX
1,PGS1,CLNS1A,NUP98,SLC9B2,AMT,FMR1,SMPD4,SMAD7,MCF2L,U
SP4,HDAC6,GLG1,ARHGEF12,ATP6V1D,VRK2,DYNC1I1,RNH1,HGS,D
ERL2,IL15RA,NARS,LANCL2,H6PD,SYTL4,DGKA,TTLL3,PRMT10,LEF1
,GLS,HLAC,PSMB9,ARHGEF25,YIPF1,ADAMTS1,RGL4,BCL2L13,BCL2L11,RBP
MS,XYLT1,GLOD4,STARD13,STARD9,COG4,CPM,FDPS,NISCH,PAM,
ABCC1,CEP135,GLT8D1,HSD17B12,DDX23,HLADQA1,AP3S2,APITD1,MPDU1,UHMK1,USP47,ADAM8,MAP7D1,NOL3,
CAPZB,DNAJC10,RNF220,RAB35,XAF1,CD9,CDC37L1,RANBP1,SIPA1
L1,MARCH6,DDX39A,KRIT1,KPNA6,SKIV2L,MINK1,PDLIM5,RNF24,RH
OF,PTPN6,EEF1A1,ACTR3,VASP,CMIP,CSNK2A1,IGBP1,UPF3A,NOD
1,PRKACA,STAT2,ANAPC4,RPP14,DHX9,PIGS,PLK1,SDCCAG8,PNPO
,VPS52,LMAN2,PDE7B,PREPL,ASNS,COL16A1,ECHDC1,NUTF2,TTC1
9,DNM1L,TXNL1,PTGES2,UPF1,HDGF,FDXR,RC3H1,PPP5C,PIGG,PD
XK,NPC1,SHISA5,RHOBTB1,HERC2,ZC3H12A,NUP210,TBC1D10B,SE
PT4,MIB2,SLC11A2,SYMPK,EFTUD2,AAMP,RAB24,ATG4B,CNP,CLN8,
PIGN,GCDH,VAMP7,BCLAF1,CAMK2D,HLADMB,ZNF397,SLC16A1,PLCB4,BBS1,DNPEP,TBC1D14,GALK2,PRPF3,
TNK2,ENGASE,COL14A1,USP20,FLG,STK11IP,STK4,FUBP3,TRO,MT
G1,RARS,ZNF540,SIKE1,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR1,H
PS4,PAIP1,CAPRIN1,MMP16,NADSYN1,ADCY4,CELF1,SNCAIP,PDE4
D,AFAP1,RNASET2,TIMM23,PAF1,TAB2,SGK1,SHARPIN,DPF2,TCHP,
CPT1B,CHKB,NADK,IDI1,RUSC2,KIAA0586,CYP2R1,SEC31A,MDM2,R
HBDD1,SNAP23,COL12A1,FKBP1A,ZFYVE26,PRKCH,DAZAP1,ANAPC
16,PPM1F,TBP,DIS3L,IDH3G,FAM13A,TLN2,GPAT2,GMEB2,SSH2,TH
BS3,MCFD2,PFDN5,TTC1,TRAF3IP1,SRP9,RALGPS2,FLII,TNFRSF25,
PLEKHG5,QSOX1,CCNDBP1,DDX58,ALDH6A1,RPL27,LCP2,SNX13,D
FNA5,AP4B1,RHBDF1,SERPINH1,MAGI1,SNX21,NF1,ZEB1,ACAA1,NE
K3,EIF4B,CRIP1,SERBP1,SPATS2,IFITM3,EMC3,ATG12,NUMA1,TPM4
,RGMB,COL18A1,RPL9,MED28,FKBP10,UNKL,RPS6KA5,G3BP1,RAB3
2
G
O:
00
43
22
6
organelle
1,ALKBH3,ADSL,ALG6,ST3GAL4,CAPN10,DCAF8,GCNT2,PKD2,CASP
2,STRN4,GALT,UBAC1,LMNA,NUDT6,RSL1D1,NOL8,PPP2R3C,GOLG
A8B,GOLGA8A,PRMT5,MAPK8IP3,GNAI1,PLEKHA2,STX16,DHRS1,ZF
PM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,PAFAH1B1,LYRM2,SENP2,IS
YNA1,EDEM2,GPCPD1,IL18,RPS19BP1,PUM2,MTCH1,CALCOCO2,ST
ARD3,TPP1,SYTL2,DNALI1,PWP2,CHMP1A,PDE8A,AACS,ARPC2,SYN
E1,STK38L,EPN2,DDX6,ANXA5,GALNT2,ADAM15,SH3BP5,USP33,ZN
F263,BICD1,NTMT1,RGS3,GCC2,GARS,CYTH2,CCDC115,GRB10,MR
PS7,PLK2,PAN2,HEXA,USP7,PLD6,FLCN,NRP1,PTGR2,FAM172A,FM
O2,GMDS,RPL24,IGFBP6,DAAM1,ARHGAP9,UST,MTMR14,RPL37A,M
AST2,STX2,PTEN,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,IQGAP1,FBXW
7,CEP112,PHPT1,PTP4A2,LGMN,SMARCD3,HERPUD1,IKBKB,CTNS,R
QCD1,SNX17,GGNBP2,PXN,KPNB1,SRGAP2,NCOR1,ATP11B,MEF2A,
DYM,OXCT1,PARN,TNS1,FECH,ERAL1,COX7A2L,SMEK1,WASH4P,IT
GB5,TMEM189,TCTN1,NECAB3,FIBP,SSBP1,CLSTN2,CACNB1,MAPK
8,CLTCL1,MYLK,USP15,DDX41,MAN1A2,OSBPL3,HLAF,RNF213,ABCA2,RAB8A,ZFAND2B,AFF4,SLC35D2,DENND4C,DMTF1
,MAP4K4,CSK,CDK5RAP2,COL9A3,ITPA,OAZ1,PSMC6,TMEM66,SWA
P70,STX18,TBCD,IMPDH1,RNF146,EMC4,DSN1,CDK6,NSFL1C,AGBL
5,WDR61,NUP37,DDHD2,COX14,APPL2,FARSA,ZNF148,CLTB,FLOT1,
WDR13
MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1,PLEK
HA3,PBX2,LPP,KANK2,ACADVL,GTF3C2,CADM1,RAI1,PSMB10,XRN1,
CKB,IGF1R,AVL9,LAMB1,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,
cell UTRN,RALGAPA2,MYNN,TRNAU1AP,RAI14,NOC2L,PPIL2,TARS,RAF1
ular ,NLRP1,ZNF131,SEPT5,TSTD1,LEPRE1,SLC16A3,PPP1R13B,GAS8,C
_co OL9A1,RSC1A1,SFSWAP,CDK13,RBM6,BDNF,TAZ,SIN3B,SPOP,CPE,
mpo CBX5,SART1,COL2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HL
nent ADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,SHMT2,ZFP91,
CNTF,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLNS1A,NUP98,E
1.18
304
856
8
1.
2
4
E
1
9
ED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,USP4,HDAC6,GLG1,EHMT1,A
TP6V1D,VRK2,DYNC1I1,ZNF496,HGS,DERL2,IL15RA,NARS,LANCL2,
H6PD,SYTL4,TTLL3,ARPC4-TTLL3,PNKP,LEF1,GLS,PAX8,HLAC,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,YIPF1,ADAMTS1,RGL4,
BCL2L13,BCL2L11,RBPMS,XYLT1,GLOD4,STARD13,ZSCAN31,STARD
9,XBP1,COG4,CPM,FDPS,NISCH,PAM,ABCC1,NOM1,CEP135,GLT8D1
,SNRNP70,HSD17B12,DDX23,HLADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,MARK4,UHMK1,ADAM
8,MAP7D1,NOL3,POLR3E,CAPZB,GABPB1,PRPF40A,DNAJC10,RAB3
5,XAF1,CD9,PCGF6,RANBP1,SIPA1L1,MARCH6,DDX39A,KRIT1,KPNA
6,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTPN6,SUGP1,EEF1A1,ACTR
3,LHX4,VASP,CMIP,CSNK2A1,UPF3A,PRKACA,STAT2,ANAPC4,RPP1
4,DHX9,PIGS,PLK1,SDCCAG8,ZNF446,VPS52,LMAN2,COL16A1,NUTF
2,TTC19,DNM1L,TXNL1,PTGES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,P
PP5C,PIGG,PDXK,NPC1,SHISA5,CCNL1,HERC2,CHD6,ZC3H12A,NUP
210,SEPT4,MIB2,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,RAB24,CNP,
CLN8,TBX18,PIGN,GCDH,LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D
,FYTTD1,ZNF721,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,TBC1D14,PRP
F3,TNK2,COL14A1,GIT2,FLG,WAC,STK4,ZNF142,FUBP3,TRO,MTG1,C
CDC14,RARS,ZNF540,SIKE1,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR
1,HPS4,HSF4,CAPRIN1,GTF3C1,MMP16,PMS1,CELF1,SNCAIP,PDE4
D,AFAP1,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,SHARPIN,DPF2,
TCHP,CPT1B,IDI1,RNF8,CDYL2,KIAA0586,CYP2R1,SEC31A,MDM2,R
HBDD1,SNAP23,COL12A1,FKBP1A,ZFYVE26,DAZAP1,ANAPC16,ZNF5
95,TBP,DIS3L,IDH3G,YY1,TLN2,INO80,GPAT2,GMEB2,SSH2,MCFD2,P
FDN5,TTC1,CREB1,TRAF3IP1,SRP9,FLII,QSOX1,RPRD1A,CCNDBP1,
DDX58,ALDH6A1,RPL27,CCNL2,PTPRK,SNX13,AP4B1,RHBDF1,SERP
INH1,SNX21,NF1,ZEB1,ACAA1,NEK3,SERBP1,SETBP1,NUB1,IFITM3,
EMC3,LGALS3BP,NUMA1,TPM4,RGMB,COL18A1,EBF1,RPL9,MED28,
PHF15,FKBP10,UNKL,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,
ADSL,ALG6,ST3GAL4,DCAF8,GCNT2,ZNF837,PKD2,CASP2,HNRNPA
G
O:
00
43
22
9
intracellular organelle
3,RXRB,GALT,UBAC1,LMNA,NUDT6,RSL1D1,MITF,NOL8,PPP2R3C,R
B1,GOLGA8B,GOLGA8A,PRMT5,HMGXB3,MAPK8IP3,GNAI1,USP3,PL
EKHA2,STX16,DHRS1,MZF1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEX
N,RNF168,PAFAH1B1,ZNF865,LYRM2,SENP2,EDEM2,RPS19BP1,PU
M2,MTCH1,SLFN11,CALCOCO2,STARD3,TPP1,SYTL2,DNALI1,SUB1,
PWP2,CHMP1A,NSA2,ARPC2,SYNE1,STK38L,EPN2,DDX6,ZNF558,AN
XA5,GALNT2,ADAM15,SH3BP5,MUM1,ZNF263,ZNF180,BICD1,NTMT1,
ZNF276,RGS3,GCC2,NR1H3,GARS,CYTH2,CCDC115,MRPS7,PLK2,P
AN2,HEXA,USP7,PLD6,FLCN,NRP1,ZNF605,CHFR,ZNF410,FAM172A,
FMO2,RPL24,IGFBP6,DAAM1,UST,RPL37A,SAP30BP,MAST2,STX2,VP
S72,PTEN,FYN,IDH1,SRPK1,RUNX2,CSTF1,IQGAP1,FBXW7,CEP112,I
NTS4,PTP4A2,LGMN,SMARCD3,HERPUD1,IFT172,IKBKB,CTNS,RQC
D1,SNX17,GGNBP2,PXN,KPNB1,SRGAP2,RFX7,NCOR1,ATP11B,PPP
1R10,MEF2A,DYM,OXCT1,PARN,ZMYM5,TNS1,FECH,ERAL1,PRKRIP
1,SETD8,COX7A2L,SMEK1,WASH4P,ITGB5,TMEM189,TCTN1,STK19,
NECAB3
MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1,PLEK
HA3,PBX2,LPP,KANK2,ACADVL,GTF3C2,CADM1,RAI1,PSMB10,XRN1,
CKB,IGF1R,AVL9,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,R
ALGAPA2,MYNN,TRNAU1AP,RAI14,NOC2L,PPIL2,TARS,RAF1,NLRP1,
ZNF131,SEPT5,TSTD1,LEPRE1,SLC16A3,PPP1R13B,GAS8,COL9A1,R
SC1A1,SFSWAP,CDK13,RBM6,BDNF,TAZ,SIN3B,SPOP,CPE,CBX5,SA
cell
RT1,COL2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HLAular
DPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
_co
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,SHMT2,ZFP91,
mpo
CNTF,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLNS1A,NUP98,E
nent
ED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,USP4,HDAC6,GLG1,EHMT1,A
TP6V1D,VRK2,DYNC1I1,ZNF496,HGS,DERL2,IL15RA,NARS,LANCL2,
H6PD,SYTL4,TTLL3,ARPC4-TTLL3,PNKP,LEF1,GLS,PAX8,HLAC,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,YIPF1,ADAMTS1,RGL4,
BCL2L13,BCL2L11,RBPMS,XYLT1,GLOD4,STARD13,ZSCAN31,STARD
9,XBP1,COG4,CPM,FDPS,NISCH,PAM,ABCC1,NOM1,CEP135,GLT8D1
1.18
113
616
3
4.
2
4
E
1
9
,SNRNP70,HSD17B12,DDX23,HLADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,MARK4,UHMK1,ADAM
8,MAP7D1,NOL3,POLR3E,CAPZB,GABPB1,PRPF40A,DNAJC10,RAB3
5,XAF1,CD9,PCGF6,RANBP1,SIPA1L1,MARCH6,DDX39A,KRIT1,KPNA
6,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTPN6,SUGP1,EEF1A1,ACTR
3,LHX4,VASP,CMIP,CSNK2A1,UPF3A,PRKACA,STAT2,ANAPC4,RPP1
4,DHX9,PIGS,PLK1,SDCCAG8,ZNF446,VPS52,LMAN2,COL16A1,NUTF
2,TTC19,DNM1L,TXNL1,PTGES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,P
PP5C,PIGG,PDXK,NPC1,SHISA5,CCNL1,HERC2,CHD6,ZC3H12A,NUP
210,SEPT4,MIB2,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,RAB24,CNP,
CLN8,TBX18,PIGN,GCDH,LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D
,FYTTD1,ZNF721,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,TBC1D14,PRP
F3,TNK2,COL14A1,GIT2,FLG,WAC,STK4,ZNF142,FUBP3,TRO,MTG1,C
CDC14,RARS,ZNF540,SIKE1,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR
1,HPS4,HSF4,CAPRIN1,GTF3C1,MMP16,PMS1,CELF1,SNCAIP,PDE4
D,AFAP1,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,SHARPIN,DPF2,
TCHP,CPT1B,IDI1,RNF8,CDYL2,KIAA0586,CYP2R1,SEC31A,MDM2,R
HBDD1,SNAP23,COL12A1,FKBP1A,ZFYVE26,DAZAP1,ANAPC16,ZNF5
95,TBP,DIS3L,IDH3G,YY1,TLN2,INO80,GPAT2,GMEB2,SSH2,MCFD2,P
FDN5,TTC1,CREB1,TRAF3IP1,SRP9,FLII,QSOX1,RPRD1A,CCNDBP1,
DDX58,ALDH6A1,RPL27,CCNL2,PTPRK,SNX13,AP4B1,RHBDF1,SERP
INH1,SNX21,NF1,ZEB1,ACAA1,NEK3,SERBP1,SETBP1,NUB1,IFITM3,
EMC3,NUMA1,TPM4,RGMB,COL18A1,EBF1,RPL9,MED28,PHF15,FKB
P10,UNKL,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,
ST3GAL4,DCAF8,GCNT2,ZNF837,PKD2,CASP2,HNRNPA3,RXRB,GAL
T,UBAC1,LMNA,NUDT6,RSL1D1,MITF,NOL8,PPP2R3C,RB1,GOLGA8B
,GOLGA8A,PRMT5,HMGXB3,MAPK8IP3,GNAI1,USP3,PLEKHA2,STX16
,DHRS1,MZF1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,RNF168,PA
FAH1B1,ZNF865,LYRM2,SENP2,EDEM2,RPS19BP1,PUM2,MTCH1,SL
FN11,CALCOCO2,STARD3,TPP1,SYTL2,DNALI1,SUB1,PWP2,CHMP1
A,NSA2,ARPC2,SYNE1,STK38L,EPN2,DDX6,ZNF558,GALNT2,ADAM1
G
O:
00
43
22
7
membrane-bounded organelle
5,SH3BP5,MUM1,ZNF263,ZNF180,BICD1,NTMT1,ZNF276,RGS3,GCC2
,NR1H3,GARS,CYTH2,CCDC115,MRPS7,PLK2,PAN2,HEXA,USP7,PLD
6,FLCN,NRP1,ZNF605,CHFR,ZNF410,FAM172A,FMO2,RPL24,IGFBP6,
DAAM1,UST,RPL37A,SAP30BP,MAST2,STX2,VPS72,PTEN,FYN,IDH1,
SRPK1,RUNX2,CSTF1,IQGAP1,FBXW7,CEP112,INTS4,PTP4A2,LGMN,
SMARCD3,HERPUD1,IFT172,IKBKB,CTNS,RQCD1,SNX17,GGNBP2,P
XN,KPNB1,SRGAP2,RFX7,NCOR1,ATP11B,PPP1R10,MEF2A,DYM,OX
CT1,PARN,ZMYM5,TNS1,FECH,ERAL1,PRKRIP1,SETD8,COX7A2L,SM
EK1,WASH4P,ITGB5,TMEM189,TCTN1,STK19,NECAB3,PIAS2,FIBP,S
SBP1
MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1,PLEK
HA3,PBX2,LPP,KANK2,ACADVL,GTF3C2,CADM1,RAI1,PSMB10,XRN1,
CKB,IGF1R,AVL9,LAMB1,NPHP3,PTS,MYO1D,SIRT2,EPHX2,UTRN,RA
LGAPA2,MYNN,TRNAU1AP,RAI14,NOC2L,PPIL2,RAF1,NLRP1,ZNF131
,SEPT5,TSTD1,LEPRE1,SLC16A3,PPP1R13B,GAS8,COL9A1,RSC1A1,
SFSWAP,CDK13,RBM6,BDNF,TAZ,SIN3B,SPOP,CPE,CBX5,SART1,CO
L2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,SHMT2,ZFP91,
cell
CNTF,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLNS1A,NUP98,E
ular
ED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,USP4,HDAC6,GLG1,EHMT1,A
_co
TP6V1D,VRK2,ZNF496,HGS,DERL2,IL15RA,NARS,LANCL2,H6PD,SYT
mpo
L4,TTLL3,PNKP,LEF1,GLS,PAX8,HLAnent
C,SUPT4H1,ZNF83,PSMB9,EMX2,YIPF1,RGL4,BCL2L13,BCL2L11,RBP
MS,XYLT1,GLOD4,STARD13,ZSCAN31,STARD9,XBP1,COG4,CPM,FD
PS,NISCH,PAM,ABCC1,NOM1,GLT8D1,SNRNP70,HSD17B12,DDX23,H
LADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,UHMK1,ADAM8,NOL3,
POLR3E,GABPB1,PRPF40A,DNAJC10,RAB35,XAF1,CD9,PCGF6,RAN
BP1,MARCH6,DDX39A,KPNA6,SKIV2L,MINK1,RNF24,PTPN6,SUGP1,E
EF1A1,ACTR3,LHX4,CMIP,CSNK2A1,UPF3A,PRKACA,STAT2,ANAPC4
,RPP14,DHX9,PIGS,PLK1,ZNF446,VPS52,LMAN2,COL16A1,NUTF2,TT
1.20
172
255
3
2.
3
3
E
1
8
C19,DNM1L,TXNL1,PTGES2,UPF1,ZNF621,HDGF,FDXR,PPP5C,PIGG,
PDXK,NPC1,SHISA5,CCNL1,HERC2,CHD6,ZC3H12A,NUP210,SEPT4,
MIB2,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,RAB24,CNP,CLN8,TBX1
8,PIGN,GCDH,LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,Z
NF721,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,TBC1D14,PRP
F3,TNK2,COL14A1,GIT2,FLG,WAC,STK4,ZNF142,FUBP3,TRO,MTG1,R
ARS,ZNF540,SIKE1,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR1,HPS4,
HSF4,GTF3C1,MMP16,PMS1,CELF1,SNCAIP,RNASET2,SF3A2,TIMM2
3,PAF1,TAB2,SGK1,DPF2,TCHP,CPT1B,IDI1,RNF8,CDYL2,CYP2R1,SE
C31A,MDM2,RHBDD1,SNAP23,COL12A1,FKBP1A,DAZAP1,ANAPC16,
ZNF595,TBP,IDH3G,YY1,INO80,GPAT2,GMEB2,MCFD2,PFDN5,TTC1,
CREB1,SRP9,FLII,QSOX1,RPRD1A,CCNDBP1,ALDH6A1,CCNL2,PTPR
K,SNX13,AP4B1,RHBDF1,SERPINH1,SNX21,NF1,ZEB1,ACAA1,NEK3,
SERBP1,SETBP1,NUB1,IFITM3,EMC3,LGALS3BP,NUMA1,RGMB,COL
18A1,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,ZNF3,RPS6KA5,G3BP
1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,DCAF8,GCNT2,ZNF83
7,PKD2,CASP2,HNRNPA3,RXRB,GALT,UBAC1,LMNA,NUDT6,RSL1D1,
MITF,NOL8,PPP2R3C,RB1,GOLGA8B,GOLGA8A,PRMT5,HMGXB3,MA
PK8IP3,GNAI1,USP3,PLEKHA2,STX16,DHRS1,MZF1,ZFPM2,TP53BP1,
BLOC1S5,TXNDC5,RNF168,PAFAH1B1,ZNF865,LYRM2,SENP2,EDEM
2,RPS19BP1,MTCH1,SLFN11,CALCOCO2,STARD3,TPP1,SYTL2,DNAL
I1,SUB1,PWP2,CHMP1A,NSA2,ARPC2,SYNE1,STK38L,EPN2,ZNF558,
ANXA5,GALNT2,ADAM15,SH3BP5,MUM1,ZNF263,ZNF180,BICD1,NTM
T1,ZNF276,RGS3,GCC2,NR1H3,GARS,CYTH2,CCDC115,MRPS7,PAN
2,HEXA,USP7,PLD6,FLCN,ZNF605,CHFR,ZNF410,FAM172A,FMO2,IGF
BP6,UST,SAP30BP,STX2,VPS72,PTEN,FYN,IDH1,SRPK1,RUNX2,CST
F1,IQGAP1,FBXW7,INTS4,PTP4A2,LGMN,SMARCD3,HERPUD1,IFT17
2,IKBKB,CTNS,RQCD1,SNX17,GGNBP2,KPNB1,SRGAP2,RFX7,NCOR
1,ATP11B,PPP1R10,MEF2A,DYM,OXCT1,PARN,ZMYM5,FECH,ERAL1,
PRKRIP1,SETD8,COX7A2L,SMEK1,WASH4P,ITGB5,TMEM189,TCTN1,
STK19,NECAB3,PIAS2,FIBP,SSBP1,CLSTN2,CACNB1,MAPK8,MYCBP
G
O:
00
44
44
6
intracellular organelle part
2,CLTCL1,USP15,DDX41,MAN1A2,SRRM2,OSBPL3,PBX3,HLAF,ZNF565,ABCA2,RAB8A,ZFAND2B,AFF4,SLC35D2,TRIM28,DENND4
C,DMTF1,CSK,CDK5RAP2,COL9A3,PSMC6,TMEM66,SWAP70,RPF2,S
TX18,IMPDH1,RNF146,UBP1,EMC4,SKIV2L2,DSN1,CDK6,NSFL1C,AG
BL5,WDR61,EBF4
RNASEH2B,SLC25A37,CRBN,OBFC1,PBX2,ACADVL,GTF3C2,PSMB10
,MYO1D,SIRT2,EPHX2,UTRN,NOC2L,PPIL2,RAF1,SEPT5,LEPRE1,SL
C16A3,PPP1R13B,GAS8,COL9A1,RSC1A1,CDK13,TAZ,SIN3B,CPE,CB
X5,SART1,COL2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,BCL6,FUBP1,CMPK2,TBX2,MMS19,
SHMT2,ZFP91,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,NUP98,E
ED,SLC9B2,FMR1,SMPD4,SMAD7,HDAC6,GLG1,ATP6V1D,VRK2,DYN
C1I1,ZNF496,HGS,DERL2,IL15RA,LANCL2,H6PD,SYTL4,TTLL3,ARPC4
-TTLL3,PNKP,LEF1,GLS,PAX8,HLAC,SUPT4H1,PSMB9,BCL2L13,BCL2L11,XYLT1,STARD13,STARD9,XBP
1,COG4,CPM,FDPS,PAM,ABCC1,NOM1,CEP135,SNRNP70,HSD17B12
cell ,DDX23,HLAular DQA1,AP3S2,METTL3,APITD1,MPDU1,MARK4,ADAM8,MAP7D1,NOL3,
_co POLR3E,CAPZB,PRPF40A,DNAJC10,CD9,PCGF6,RANBP1,SIPA1L1,M
mpo ARCH6,MINK1,PDLIM5,RNF24,SUGP1,ACTR3,CSNK2A1,UPF3A,PRKA
nent CA,STAT2,ANAPC4,DHX9,PIGS,PLK1,SDCCAG8,VPS52,LMAN2,COL1
6A1,NUTF2,TTC19,DNM1L,PTGES2,UPF1,HDGF,FDXR,PIGG,PDXK,N
PC1,SHISA5,CCNL1,HERC2,ZC3H12A,NUP210,SEPT4,SLC11A2,SYM
PK,EFTUD2,CNP,CLN8,PIGN,GCDH,PCGF1,VAMP7,DR1,BCLAF1,CA
MK2D,FYTTD1,HLADMB,JHDM1D,PLCB4,BBS1,PRPF3,TNK2,COL14A1,GIT2,FLG,WAC,M
TG1,CCDC14,RARS,ALDH18A1,TPCN2,COPS7B,VTI1A,GTF3C1,MMP
16,PMS1,SNCAIP,PDE4D,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,
SHARPIN,DPF2,TCHP,CPT1B,RNF8,KIAA0586,CYP2R1,SEC31A,MDM
2,RHBDD1,SNAP23,COL12A1,FKBP1A,ZFYVE26,DAZAP1,ANAPC16,T
BP,DIS3L,IDH3G,YY1,INO80,GPAT2,GMEB2,MCFD2,TTC1,CREB1,SR
P9,FLII,QSOX1,RPRD1A,ALDH6A1,RPL27,CCNL2,SNX13,RHBDF1,SE
1.29
525
701
4
3.
8
8
E
1
8
RPINH1,SNX21,ZEB1,ACAA1,IFITM3,EMC3,NUMA1,TPM4,COL18A1,R
PL9,MED28,PHF15,FKBP10,ZNF3,RPS6KA5,NIPBL,RAB31,ALKBH3,AL
G6,ST3GAL4,GCNT2,PKD2,HNRNPA3,RXRB,LMNA,RSL1D1,NOL8,PP
P2R3C,RB1,GOLGA8B,GOLGA8A,MAPK8IP3,GNAI1,USP3,STX16,DHR
S1,ZFPM2,TP53BP1,TXNDC5,RNF168,PAFAH1B1,SENP2,EDEM2,RPS
19BP1,MTCH1,CALCOCO2,STARD3,TPP1,DNALI1,SUB1,PWP2,CHMP
1A,NSA2,ARPC2,SYNE1,STK38L,EPN2,GALNT2,ZNF263,BICD1,NTMT
1,NR1H3,GARS,MRPS7,PLK2,HEXA,USP7,PLD6,NRP1,CHFR,FMO2,R
PL24,DAAM1,UST,RPL37A,SAP30BP,PTEN,FYN,IDH1,SRPK1,RUNX2,
CSTF1,IQGAP1,FBXW7,CEP112,INTS4,LGMN,SMARCD3,HERPUD1,C
TNS,SNX17,PXN,KPNB1,SRGAP2,NCOR1,ATP11B,PPP1R10,MEF2A,
OXCT1,PARN,FECH,ERAL1,PRKRIP1,COX7A2L,SMEK1,WASH4P,TM
EM189,TCTN1,NECAB3,PIAS2,SSBP1,CLSTN2,MAPK8,CLTCL1,MYLK,
DDX41,MAN1A2,SRRM2,OSBPL3,PBX3,HLAF,ABCA2,RAB8A,AFF4,SLC35D2,TRIM28,DENND4C,DMTF1,CSK,CDK
5RAP2,COL9A3,PSMC6,TMEM66,RPF2,STX18,TBCD,EMC4,SKIV2L2,
DSN1,NSFL1C,WDR61,NUP37,PRPF8,DDHD2,COX14,APPL2,ZNF148,
CLTB,FLOT1,WDR13,PSMC4,HNRNPL,KIFC2,STAG2,SP110,GOPC,RA
NBP9,PPA2,ST6GALNAC5,WDR35,ATPAF2,PAK1,EVC,LEPROT,RAB1
0,RHEB,HNRNPH3,VPS45,TCF4,ACD,HMGN2,WDR4,ATP6V0A1,ERC1
,TIMM50,OS9,DGKZ,ACTR2,NFYC,P4HB,HSD17B4,ELOVL1,FUT4,SRS
F10,TMED3,SS18,SMAD4,GRPEL2,FNTB,KLC1,NAV1,TGFB1I1,SLC35
A4,INO80E,DTYMK,SLC39A7,EZR,RPL4,MTRR,CENPT,MBOAT2,ZNF4
4,AUP1,GOLPH3,ING4,ZNF687,CDC14B,CLK3,DNHD1,NR2C2,FHOD1,
FIP1L1,DLST,DNTTIP2,LRPAP1,MRPL49,FLNA,RAB5A,IRF9,CA5B,SU
N2,MSL1,HGSNAT,MGAT5,BCS1L,ACTR10,ATP5A1,GLI3,TMED2,ADD
3,NDUFV1,MAPK12,NDUFS2,RASGRF2,AK5,GUSB,THOC2,MCOLN1,B
4GALT4,ENG,SCFD1,SIRT7,TCF12,PCSK7,ARNT,NOX4,ETFA,EXT1,E
RCC1,PHF1,GAA,B3GAT3,SLC25A6,PRELID1,SDHA,PHF12,PDIA5,TB
CE,VAMP4,REXO2,MED6,CIRBP,NUP85,IDH3B,HAUS5,RGS2,CLIP2,H
INFP,STAM2,NCBP2,MAN2A2,LPCAT1,PDGFRB,COL8A1,EBPL,VPS51
,TGS1,DZIP1,NCAPD3
G
O:
00
43
23
1
intracellular membrane-bounded organelle
MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1,PLEK
HA3,PBX2,LPP,KANK2,ACADVL,GTF3C2,CADM1,RAI1,PSMB10,XRN1,
CKB,IGF1R,AVL9,NPHP3,PTS,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA
2,MYNN,TRNAU1AP,RAI14,NOC2L,PPIL2,RAF1,NLRP1,ZNF131,SEPT
5,TSTD1,LEPRE1,SLC16A3,PPP1R13B,GAS8,COL9A1,RSC1A1,SFSW
AP,CDK13,RBM6,BDNF,TAZ,SIN3B,SPOP,CPE,CBX5,SART1,COL2A1,
CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,SHMT2,ZFP91,
CNTF,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLNS1A,NUP98,E
ED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,USP4,HDAC6,GLG1,EHMT1,A
TP6V1D,VRK2,ZNF496,HGS,DERL2,IL15RA,NARS,LANCL2,H6PD,SYT
L4,TTLL3,PNKP,LEF1,GLS,PAX8,HLAC,SUPT4H1,ZNF83,PSMB9,EMX2,YIPF1,RGL4,BCL2L13,BCL2L11,RBP
cell
MS,XYLT1,GLOD4,STARD13,ZSCAN31,STARD9,XBP1,COG4,CPM,FD
ular
PS,NISCH,PAM,ABCC1,NOM1,GLT8D1,SNRNP70,HSD17B12,DDX23,H
_co
LAmpo
DQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,UHMK1,ADAM8,NOL3,
nent
POLR3E,GABPB1,PRPF40A,DNAJC10,RAB35,XAF1,CD9,PCGF6,RAN
BP1,MARCH6,DDX39A,KPNA6,SKIV2L,MINK1,RNF24,PTPN6,SUGP1,E
EF1A1,ACTR3,LHX4,CMIP,CSNK2A1,UPF3A,PRKACA,STAT2,ANAPC4
,RPP14,DHX9,PIGS,PLK1,ZNF446,VPS52,LMAN2,COL16A1,NUTF2,TT
C19,DNM1L,TXNL1,PTGES2,UPF1,ZNF621,HDGF,FDXR,PPP5C,PIGG,
PDXK,NPC1,SHISA5,CCNL1,HERC2,CHD6,ZC3H12A,NUP210,SEPT4,
MIB2,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,RAB24,CNP,CLN8,TBX1
8,PIGN,GCDH,LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,Z
NF721,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,TBC1D14,PRP
F3,TNK2,COL14A1,GIT2,FLG,WAC,STK4,ZNF142,FUBP3,TRO,MTG1,R
ARS,ZNF540,SIKE1,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR1,HPS4,
HSF4,GTF3C1,MMP16,PMS1,CELF1,SNCAIP,RNASET2,SF3A2,TIMM2
3,PAF1,TAB2,SGK1,DPF2,TCHP,CPT1B,IDI1,RNF8,CDYL2,CYP2R1,SE
1.19
992
138
2
6.
4
3
E
1
8
G
O:
00
44
42
organelle part
C31A,MDM2,RHBDD1,SNAP23,COL12A1,FKBP1A,DAZAP1,ANAPC16,
ZNF595,TBP,IDH3G,YY1,INO80,GPAT2,GMEB2,MCFD2,PFDN5,TTC1,
CREB1,SRP9,FLII,QSOX1,RPRD1A,CCNDBP1,ALDH6A1,CCNL2,PTPR
K,SNX13,AP4B1,RHBDF1,SERPINH1,SNX21,NF1,ZEB1,ACAA1,NEK3,
SERBP1,SETBP1,NUB1,IFITM3,EMC3,NUMA1,RGMB,COL18A1,EBF1,
RPL9,MED28,PHF15,FKBP10,UNKL,ZNF3,RPS6KA5,G3BP1,NIPBL,RA
B31,ALKBH3,ADSL,ALG6,ST3GAL4,DCAF8,GCNT2,ZNF837,PKD2,CAS
P2,HNRNPA3,RXRB,GALT,UBAC1,LMNA,NUDT6,RSL1D1,MITF,NOL8,
PPP2R3C,RB1,GOLGA8B,GOLGA8A,PRMT5,HMGXB3,MAPK8IP3,GNA
I1,USP3,PLEKHA2,STX16,DHRS1,MZF1,ZFPM2,TP53BP1,BLOC1S5,T
XNDC5,RNF168,PAFAH1B1,ZNF865,LYRM2,SENP2,EDEM2,RPS19BP
1,MTCH1,SLFN11,CALCOCO2,STARD3,TPP1,SYTL2,DNALI1,SUB1,P
WP2,CHMP1A,NSA2,ARPC2,SYNE1,STK38L,EPN2,ZNF558,GALNT2,A
DAM15,SH3BP5,MUM1,ZNF263,ZNF180,BICD1,NTMT1,ZNF276,RGS3,
GCC2,NR1H3,GARS,CYTH2,CCDC115,MRPS7,PAN2,HEXA,USP7,PLD
6,FLCN,ZNF605,CHFR,ZNF410,FAM172A,FMO2,IGFBP6,UST,SAP30B
P,STX2,VPS72,PTEN,FYN,IDH1,SRPK1,RUNX2,CSTF1,IQGAP1,FBXW
7,INTS4,PTP4A2,LGMN,SMARCD3,HERPUD1,IFT172,IKBKB,CTNS,RQ
CD1,SNX17,GGNBP2,KPNB1,SRGAP2,RFX7,NCOR1,ATP11B,PPP1R1
0,MEF2A,DYM,OXCT1,PARN,ZMYM5,FECH,ERAL1,PRKRIP1,SETD8,C
OX7A2L,SMEK1,WASH4P,ITGB5,TMEM189,TCTN1,STK19,NECAB3,PI
AS2,FIBP,SSBP1,CLSTN2,CACNB1,MAPK8,MYCBP2,CLTCL1,USP15,
DDX41,MAN1A2,SRRM2,OSBPL3,PBX3,HLAF,ZNF565,ABCA2,RAB8A,ZFAND2B,AFF4,SLC35D2,TRIM28,DENND4
C,DMTF1,CSK,CDK5RAP2,COL9A3,PSMC6,TMEM66,SWAP70,RPF2,S
TX18,IMPDH1,RNF146,UBP1,EMC4,SKIV2L2,DSN1,CDK6,NSFL1C,AG
BL5,WDR61,EBF4,NUP37,PRPF8,DDHD2
cell RNASEH2B,SLC25A37,CRBN,OBFC1,PBX2,ACADVL,GTF3C2,PSMB10
ular ,MYO1D,SIRT2,EPHX2,UTRN,NOC2L,PPIL2,RAF1,SEPT5,LEPRE1,SL
_co C16A3,PPP1R13B,GAS8,COL9A1,RSC1A1,CDK13,TAZ,SIN3B,CPE,CB
mpo X5,SART1,COL2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,HLAnent DPB1,ST3GAL1,MARCH5,UBXN1,BCL6,FUBP1,CMPK2,TBX2,MMS19,
1.28
416
554
9
2.
3
7
E
-
2
SHMT2,ZFP91,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,NUP98,E
ED,SLC9B2,FMR1,SMPD4,SMAD7,HDAC6,GLG1,ATP6V1D,VRK2,DYN
C1I1,ZNF496,HGS,DERL2,IL15RA,LANCL2,H6PD,SYTL4,TTLL3,ARPC4
-TTLL3,PNKP,LEF1,GLS,PAX8,HLAC,SUPT4H1,PSMB9,ARHGEF25,BCL2L13,BCL2L11,XYLT1,STARD13,S
TARD9,XBP1,COG4,CPM,FDPS,PAM,ABCC1,NOM1,CEP135,SNRNP7
0,HSD17B12,DDX23,HLADQA1,AP3S2,METTL3,APITD1,MPDU1,MARK4,ADAM8,MAP7D1,NOL3,
POLR3E,CAPZB,PRPF40A,DNAJC10,CD9,PCGF6,RANBP1,SIPA1L1,M
ARCH6,MINK1,PDLIM5,RNF24,SUGP1,ACTR3,CSNK2A1,UPF3A,PRKA
CA,STAT2,ANAPC4,DHX9,PIGS,PLK1,SDCCAG8,VPS52,LMAN2,COL1
6A1,NUTF2,TTC19,DNM1L,PTGES2,UPF1,HDGF,FDXR,PIGG,PDXK,N
PC1,SHISA5,CCNL1,HERC2,ZC3H12A,NUP210,SEPT4,SLC11A2,SYM
PK,EFTUD2,CNP,CLN8,PIGN,GCDH,PCGF1,VAMP7,DR1,BCLAF1,CA
MK2D,FYTTD1,HLADMB,JHDM1D,PLCB4,BBS1,PRPF3,TNK2,COL14A1,GIT2,FLG,WAC,M
TG1,CCDC14,RARS,ALDH18A1,TPCN2,COPS7B,VTI1A,GTF3C1,MMP
16,PMS1,SNCAIP,PDE4D,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,
SHARPIN,DPF2,TCHP,CPT1B,RNF8,KIAA0586,CYP2R1,SEC31A,MDM
2,RHBDD1,SNAP23,COL12A1,FKBP1A,ZFYVE26,DAZAP1,ANAPC16,T
BP,DIS3L,IDH3G,YY1,INO80,GPAT2,GMEB2,MCFD2,TTC1,CREB1,SR
P9,FLII,QSOX1,RPRD1A,ALDH6A1,RPL27,CCNL2,SNX13,RHBDF1,SE
RPINH1,SNX21,ZEB1,ACAA1,IFITM3,EMC3,NUMA1,TPM4,COL18A1,R
PL9,MED28,PHF15,FKBP10,ZNF3,RPS6KA5,NIPBL,RAB31,ALKBH3,AL
G6,ST3GAL4,GCNT2,PKD2,HNRNPA3,RXRB,LMNA,RSL1D1,NOL8,PP
P2R3C,RB1,GOLGA8B,GOLGA8A,MAPK8IP3,GNAI1,USP3,STX16,DHR
S1,ZFPM2,TP53BP1,TXNDC5,NEXN,RNF168,PAFAH1B1,SENP2,EDE
M2,RPS19BP1,MTCH1,CALCOCO2,STARD3,TPP1,DNALI1,SUB1,PWP
2,CHMP1A,NSA2,ARPC2,SYNE1,STK38L,EPN2,GALNT2,ZNF263,BICD
1,NTMT1,NR1H3,GARS,MRPS7,PLK2,HEXA,USP7,PLD6,NRP1,CHFR,
FMO2,RPL24,DAAM1,UST,RPL37A,SAP30BP,PTEN,FYN,IDH1,SRPK1,
RUNX2,CSTF1,IQGAP1,FBXW7,CEP112,INTS4,LGMN,SMARCD3,HER
1
7
G
O:
00
05
51
5
protein binding
mol
ecul
ar_f
unct
ion
PUD1,CTNS,SNX17,PXN,KPNB1,SRGAP2,NCOR1,ATP11B,PPP1R10,
MEF2A,OXCT1,PARN,FECH,ERAL1,PRKRIP1,COX7A2L,SMEK1,WAS
H4P,TMEM189,TCTN1,NECAB3,PIAS2,SSBP1,CLSTN2,MAPK8,CLTCL
1,MYLK,DDX41,MAN1A2,SRRM2,OSBPL3,PBX3,HLAF,ABCA2,RAB8A,AFF4,SLC35D2,TRIM28,DENND4C,DMTF1,CSK,CDK
5RAP2,COL9A3,PSMC6,TMEM66,RPF2,STX18,TBCD,EMC4,SKIV2L2,
DSN1,NSFL1C,WDR61,NUP37,PRPF8,DDHD2,COX14,APPL2,ZNF148,
CLTB,FLOT1,WDR13,PSMC4,HNRNPL,KIFC2,STAG2,SP110,GOPC,RA
NBP9,PPA2,ST6GALNAC5,WDR35,ATPAF2,PAK1,EVC,NCK2,LEPROT
,RAB10,RHEB,HNRNPH3,CTSH,VPS45,TCF4,ACD,HMGN2,WDR4,ATP
6V0A1,ERC1,TIMM50,OS9,DGKZ,ACTR2,NFYC,P4HB,HSD17B4,ELOV
L1,FUT4,SRSF10,TMED3,SS18,SMAD4,GRPEL2,FNTB,KLC1,NAV1,TG
FB1I1,SLC35A4,INO80E,DTYMK,SLC39A7,EZR,RPL4,MTRR,CENPT,M
BOAT2,ZNF44,AUP1,GOLPH3,ING4,ZNF687,CDC14B,CLK3,DNHD1,N
R2C2,FHOD1,FIP1L1,DLST,DNTTIP2,LRPAP1,MRPL49,FLNA,RAB5A,I
RF9,CA5B,SUN2,MSL1,HGSNAT,MGAT5,BCS1L,ACTR10,ATP5A1,GLI
3,TMED2,ADD3,NDUFV1,MAPK12,NDUFS2,RASGRF2,AK5,GUSB,THO
C2,MCOLN1,B4GALT4,ENG,SCFD1,SIRT7,TCF12,PCSK7,ARNT,NOX4,
ETFA,EXT1,ERCC1,PHF1,GAA,B3GAT3,SLC25A6,PRELID1,SDHA,PHF
12,PDIA5,TBCE,VAMP4,REXO2,MED6,CIRBP,NUP85,IDH3B,HAUS5,R
GS2,CLIP2,HINFP,STAM2,NCBP2,MAN2A2,LPCAT1,PDGFRB,COL8A1
,EBPL
FZD6,CDK14,USP10,CRBN,OBFC1,RAB3GAP2,PBX2,LPP,FAM189B,K
ANK2,EIF2B4,CADM1,XRN1,CKB,CLMN,IGF1R,LAMB1,NPHP3,PTS,TN
RC6A,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,BTN3A1,NOC2L,TARS,
RAF1,NLRP1,SEPT5,GP1BB,PPP1R13B,GAS8,CDK13,BDNF,METTL9,
SIN3B,ATP2B1,SPOP,CPE,CBX5,PLCD1,SART1,COL2A1,CCDC91,SU
PT5H,SUPT20H,MARCH5,UBXN1,DPP4,LUC7L,BCL6,TBX2,PTPN22,M
MS19,SHMT2,CNTF,EEF2K,VAPB,GPAA1,CUX1,RBM17,CLNS1A,NUP
98,EED,FMR1,SMAD7,USP4,BMP8A,HDAC6,GLG1,ARHGEF12,EHMT1
,ATP6V1D,VRK2,DYNC1I1,RNH1,ZNF496,HGS,DERL2,IL15RA,CD72,S
YTL4,LEF1,GLS,PAX8,SUPT4H1,PSMB9,EMX2,BCL2L11,RBPMS,MEP
1.23
937
089
3
1.
7
3
E
1
6
E,STARD13,STARD9,COG4,NISCH,PAM,NOM1,CEP135,SNRNP70,HS
D17B12,DDX23,RAD23A,APITD1,MARK4,UHMK1,USP47,ADAM8,NOL3
,CAPZB,GABPB1,PRPF40A,DNAJC10,CD9,PCGF6,RANBP1,SIPA1L1,
MARCH6,DDX39A,KRIT1,MINK1,PDLIM5,PTPN6,EEF1A1,ACTR3,VAS
P,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC4,PPP1R16A
,DHX9,PIGS,PLK1,SDCCAG8,VPS52,ASNS,TBC1D2B,COL16A1,NUTF
2,JAG2,TTC19,DNM1L,UPF1,HDGF,FDXR,PPP5C,PDXK,NPC1,SHISA5
,CCNL1,HERC2,ZC3H12A,NUP210,SEPT4,MIB2,SLC11A2,DIP2A,SYM
PK,EFTUD2,FAM58A,RAB24,ATG4B,IL13RA1,LSAMP,TBX18,PCGF1,V
AMP7,DR1,BCLAF1,CAMK2D,FYTTD1,JHDM1D,BBS1,JAM2,TBC1D14,
PRPF3,TNK2,COL14A1,USP20,GIT2,DCAF11,WAC,STK11IP,STK4,TR
O,RARS,ZNF540,SIKE1,TPCN2,VTI1A,FGFR1,HPS4,FBXL8,CFB,PAIP1
,USHBP1,GTF3C1,PMS1,ADCY4,CELF1,SNCAIP,PDE4D,AFAP1,TIMM
23,PAF1,TAB2,SHARPIN,TCHP,RNF8,CDYL2,SEC31A,MDM2,RHBDD1
,SNAP23,FKBP1A,ZFYVE26,PRKCH,PPM1F,TBP,DIS3L,YY1,TLN2,INO
80,SSH2,PFDN5,TTC1,CREB1,NPTN,TRAF3IP1,NAGK,FLII,CCNDBP1,
DDX58,LCP2,CCNL2,PTPRK,RHBDF1,SERPINH1,LIMCH1,MAGI1,NF1,
ZEB1,ACAA1,NEK3,EIF4B,REPS1,SERBP1,NUB1,ATG12,NUMA1,TPM
4,RGMB,COL18A1,RTKN,EBF1,MED28,NPR1,ZNF3,RPS6KA5,G3BP1,
NIPBL,ALKBH3,MRFAP1L1,BRD9,CAPN10,DCAF8,PKD2,CASP2,STRN
4,PPP1R21,RXRB,UBE2Q1,LMNA,NUDT6,MITF,NOL8,ITGA3,RB1,ANK
RD44,PRMT5,LTBP4,MAPK8IP3,GNAI1,USP3,PLEKHA2,STX16,MZF1,
ZFPM2,TP53BP1,BLOC1S5,NEXN,RNF168,MARK3,PAFAH1B1,SENP2,
IL18,RPS19BP1,PUM2,MTCH1,CALCOCO2,TPP1,SYTL2,SUB1,CHMP1
A,ARPC2,SYNE1,STK38L,DDX6,ADAM15,SH3BP5,MUM1,USP33,BICD
1,GCC2,NR1H3,GARS,CYTH2,GRB10,PLK2,HEXA,USP7,PLD6,FLCN,N
RP1,CUL4A,CHFR,TENC1,IGFBP6,DAAM1,SAP30BP,MAST2,STX2,FA
P,VPS72,PTEN,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,CSTF1,IQGAP1,C
1R,FBXW7,PHPT1,INTS4,SMARCD3,HERPUD1,IKBKB,RQCD1,SNX17,
PXN,KPNB1,SRGAP2,COMMD10,LTBR,NCOR1,ATP11B,MEF2A,DYM,
OXCT1,PARN,TNS1,FECH,LIFR,PRKRIP1,SETD8,WASH4P,ITGB5,NE
CAB3,PIAS2,FIBP,SSBP1,VILL,MAPK8,SH3BP2,MYCBP2,CLTCL1,MYL
G
O:
00
05
48
8
binding
mol
ecul
ar_f
unct
ion
K,USP15,SRRM2,OSBPL3,N6AMT1,RAB8A,ZFAND2B,AFF4,TRIM28,M
AP4K4,CSK,CDK5RAP2,CP,PTPRS,PTPRC,PSMC6,TMEM66,STX18,T
BCD,RNF146,SKIV2L2,DSN1,CDK6,ABI3BP,AGBL5,RARRES2,WDR61,
EBF4,NUP37,PRPF8,APPL2,FARSA,ZNF148,CLTB,FLOT1,PSMC4,HN
RNPL,SGSM3,STAG2,UBA2,AAK1,GOPC,RANBP9,IL10RA,ATPAF2,PH
KG2,PARD6G,PAK1,NCK2,LEPROT,LEPR,RAB10,RHEB,SEMA6A,MT
MR9,CTSH,COMMD4,ZSWIM7,TCF4,ACD,TRPM7,WDR4,SEMA4D,GN
B3,CSF1R,ATP6V0A1,ERC1,TIMM50,OS9,DGKZ,ACTR2,C3,NFYC,P4H
B,HSD17B4,ELOVL1,RPUSD4,SRSF10,ROBO3,SS18,RCOR3,SMAD4,
GRPEL2,FNTB,TBC1D22A,KLC1,C1QTNF3,TGFB1I1,INO80E,SLC4A4,
EZR,RPL4,CENPT,CREBZF,GOLPH3,TANK,ING4,USP54,CD276,RBMS
1,EIF3M,NR2C2,FHOD1,LRPAP1,MRPL49,YTHDF3,FLNA,RAB5A,IRF9,
SUN2,BCAS3,BCS1L,C1S,ATP5A1,GLI3,TMED2,THNSL2,ADD3
FZD6,CDK14,USP10,CRBN,OBFC1,RSPRY1,RAB3GAP2,PLEKHA3,PB
X2,LPP,DHX34,FAM189B,KANK2,CRIP2,ACADVL,EIF2B4,GTF3C2,CA
DM1,RAI1,XRN1,CKB,CLMN,IGF1R,LAMB1,GK5,NPHP3,PTS,TNRC6A,
MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,MYNN,TRNAU1AP,BTN3A1,
NOC2L,TARS,RAF1,NLRP1,ZNF131,SEPT5,GP1BB,LEPRE1,PPP1R13
B,GAS8,COL9A1,SFSWAP,CDK13,RBM6,BDNF,METTL9,SIN3B,ATP2B
1,SPOP,CPE,CBX5,PLCD1,SART1,COL2A1,CCDC91,RAB34,CALML4,
SUPT5H,SUPT20H,ERCC6L2,MARCH5,UBXN1,DPP4,LUC7L,BCL6,FU
BP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,GBP3,SHMT2,ZF
P91,CNTF,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLNS
1A,NUP98,EED,SLC9B2,FMR1,SMPD4,SMAD7,MCF2L,USP4,BMP8A,P
PFIBP2,HDAC6,GLG1,ARHGEF12,EHMT1,ATP6V1D,VRK2,DYNC1I1,R
NH1,ZNF496,HGS,TYW1B,DERL2,IL15RA,NARS,LANCL2,H6PD,CD72,
SYTL4,DGKA,PNKP,LEF1,GLS,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,I
TGA9,ARHGEF25,ADAMTS1,RGL4,BCL2L11,RBPMS,MEPE,STARD13,
ZSCAN31,STARD9,XBP1,COG4,CPM,FDPS,NISCH,PAM,ABCC1,NOM
1,CEP135,SNRNP70,HSD17B12,DDX23,RAD23A,METTL3,APITD1,MA
RK4,UHMK1,USP47,ADAM8,NOL3,CAPZB,GABPB1,PRPF40A,DNAJC1
0,RNF220,RAB35,XAF1,CD9,PCGF6,RANBP1,SIPA1L1,MARCH6,DDX3
1.10
872
198
6
1.
2
3
E
1
5
9A,KRIT1,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTPN6,SUGP1,EEF1A
1,ACTR3,LHX4,VASP,CMIP,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,S
TAT2,ANAPC4,RPP14,PPP1R16A,DHX9,PIGS,PLK1,SDCCAG8,ZNF44
6,PNPO,VPS52,LMAN2,PDE7B,ASNS,TBC1D2B,COL16A1,NUTF2,JAG
2,TTC19,DNM1L,PTGES2,TNRC18,UPF1,ZNF621,HDGF,FDXR,RC3H1,
PPP5C,PDXK,NPC1,SHISA5,CCNL1,RHOBTB1,HERC2,CHD6,ZC3H12
A,NUP210,SEPT4,MIB2,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,AAMP
,FAM58A,RAB24,ATG4B,IL13RA1,LSAMP,CNP,TBX18,GCDH,LBX2,PC
GF1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,ZNF721,ZNF397,JHDM1D
,ZNF710,PLCB4,BBS1,JAM2,DHRSX,DNPEP,TBC1D14,GALK2,PRPF3,
TNK2,COL14A1,USP20,GIT2,FLG,DCAF11,WAC,STK11IP,STK4,ZNF14
2,FUBP3,TRO,MTG1,RARS,ZNF540,SIKE1,ALDH18A1,TPCN2,VTI1A,M
AN2C1,FGFR1,HPS4,RAB18,HSF4,FBXL8,CFB,PAIP1,USHBP1,CAPRI
N1,GTF3C1,MMP16,NADSYN1,PMS1,ADCY4,CELF1,SNCAIP,PDE4D,A
FAP1,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,PLEKHG4,SHARPI
N,DPF2,TCHP,CHKB,NADK,IDI1,RNF8,CDYL2,CYP2R1,SEC31A,MDM2
,KCMF1,RHBDD1,SNAP23,FKBP1A,ZCCHC14,ZFYVE26,PRKCH,DAZA
P1,PPM1F,ZNF595,TBP,DIS3L,IDH3G,YY1,TLN2,INO80,GMEB2,SSH2,
THBS3,MCFD2,PFDN5,TTC1,CREB1,NPTN,TRAF3IP1,SRP9,RALGPS2
,NAGK,FLII,PLEKHG5,CCNDBP1,DDX58,ALDH6A1,ZCCHC9,FAM114A
2,LCP2,CCNL2,PTPRK,SNX13,RHBDF1,SERPINH1,LIMCH1,MAGI1,SN
X21,NF1,ZEB1,ACAA1,NEK3,EIF4B,CRIP1,REPS1,SERBP1,SETBP1,N
UB1,ATG12,NUMA1,TPM4,RGMB,COL18A1,RTKN,EBF1,RPL9,MED28,
PHF15,FKBP10,UNKL,NPR1,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,AL
KBH3,MRFAP1L1,BRD9,CAPN10,DCAF8,NTPCR,ZNF837,PKD2,CASP
2,STRN4,PPP1R21,HNRNPA3,RXRB,GALT,UBE2Q1,MDP1,LMNA,NUD
T6,RSL1D1,MITF,NOL8,PPP2R3C,ITGA3,RB1,ZZEF1,ANKRD44,PRMT
5,HMGXB3,LTBP4,MAPK8IP3,RABGGTA,GNAI1,USP3,PLEKHA2,STX1
6,DHRS1,MZF1,ZFPM2,CPPED1,TP53BP1,BLOC1S5,NEXN,RNF168,M
ARK3,PAFAH1B1,ZNF865,SENP2,ISYNA1,EDEM2,GPCPD1,IL18,RPS1
9BP1,PUM2,MTCH1,RNF217,SLFN11,CALCOCO2,STARD3,TPP1,ACB
D4,SYTL2,SUB1,CHMP1A,PDE8A,FAM200B,AACS,ARPC2,SYNE1,STK
G
O:
00
44
44
4
cytoplasmic part
38L,EPN2,DDX6,ACAP2,ZNF558,ANXA5,GALNT2,ADAM15,SH3BP5,M
UM1,USP33,ZNF263,ZNF180,BICD1,ZNF276,GCC2,NR1H3,GARS,CYT
H2,GRB10,PXDC1,MRPS7,PLK2,PAN2,HEXA,USP7,PLD6,FLCN,NRP1,
CUL4A,ZNF605,CHFR,ZNF410,PTGR2,TENC1,FMO2,GMDS,RPL24,IG
FBP6,DAAM1,ARHGAP9,RPL37A,SAP30BP,MAST2
CDK14,USP10,SLC25A37,PLEKHA3,KANK2,CRIP2,ACADVL,EIF2B4,C
ADM1,PSMB10,XRN1,CKB,AVL9,LAMB1,PTS,TNRC6A,MYO1D,EPHX2
,RALGAPA2,RAI14,PPIL2,TARS,RAF1,NLRP1,SEPT5,TSTD1,LEPRE1,
GAS8,COL9A1,RSC1A1,BDNF,TAZ,CPE,PLCD1,SART1,COL2A1,CCD
C91,RAB34,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,CMPK2,ENOSF1,PTPN22,MM
S19,SHMT2,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,CLNS1A,NU
P98,SLC9B2,AMT,FMR1,SMPD4,SMAD7,MCF2L,USP4,HDAC6,GLG1,A
RHGEF12,ATP6V1D,VRK2,DYNC1I1,HGS,DERL2,IL15RA,NARS,LANC
L2,H6PD,SYTL4,DGKA,TTLL3,GLS,HLAC,PSMB9,ARHGEF25,YIPF1,ADAMTS1,RGL4,BCL2L13,BCL2L11,XYLT
cell 1,GLOD4,STARD13,STARD9,COG4,FDPS,NISCH,PAM,ABCC1,CEP13
ular 5,GLT8D1,HSD17B12,DDX23,HLA_co DQA1,AP3S2,APITD1,MPDU1,UHMK1,ADAM8,NOL3,CAPZB,DNAJC10,
mpo RAB35,XAF1,CD9,MARCH6,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTP
nent N6,EEF1A1,ACTR3,VASP,CSNK2A1,UPF3A,NOD1,PRKACA,STAT2,AN
APC4,RPP14,DHX9,PIGS,PLK1,SDCCAG8,PNPO,VPS52,LMAN2,PDE7
B,PREPL,ASNS,COL16A1,ECHDC1,NUTF2,TTC19,DNM1L,PTGES2,UP
F1,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1,SHISA5,RHOBTB1,HERC2
,NUP210,SEPT4,MIB2,SLC11A2,RAB24,CNP,CLN8,PIGN,GCDH,VAMP
7,CAMK2D,HLADMB,SLC16A1,PLCB4,TBC1D14,TNK2,ENGASE,COL14A1,USP20,FLG
,STK4,MTG1,RARS,SIKE1,ALDH18A1,TPCN2,VTI1A,FGFR1,HPS4,PAI
P1,CAPRIN1,MMP16,NADSYN1,PDE4D,RNASET2,TIMM23,PAF1,TAB2
,SGK1,SHARPIN,TCHP,CPT1B,CHKB,NADK,IDI1,RUSC2,CYP2R1,SEC
31A,MDM2,RHBDD1,SNAP23,COL12A1,FKBP1A,PRKCH,PPM1F,DIS3
L,IDH3G,FAM13A,GPAT2,THBS3,MCFD2,PFDN5,TTC1,SRP9,TNFRSF
1.27
117
503
3
1.
8
6
E
1
5
25,PLEKHG5,QSOX1,DDX58,ALDH6A1,RPL27,LCP2,SNX13,AP4B1,RH
BDF1,SERPINH1,SNX21,ACAA1,EIF4B,SERBP1,IFITM3,EMC3,ATG12,
NUMA1,TPM4,RGMB,COL18A1,RPL9,MED28,FKBP10,RPS6KA5,G3BP
1,RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,CAPN10,DCAF8,GCNT2,PKD
2,CASP2,GALT,UBAC1,LMNA,NUDT6,RSL1D1,GOLGA8B,GOLGA8A,P
RMT5,MAPK8IP3,GNAI1,STX16,DHRS1,BLOC1S5,TXNDC5,NEXN,PAF
AH1B1,LYRM2,EDEM2,GPCPD1,IL18,PUM2,MTCH1,CALCOCO2,STAR
D3,TPP1,SYTL2,CHMP1A,PDE8A,AACS,ARPC2,SYNE1,EPN2,DDX6,G
ALNT2,ADAM15,SH3BP5,USP33,BICD1,RGS3,GCC2,GARS,CCDC115,
GRB10,MRPS7,PLK2,PAN2,HEXA,USP7,PLD6,NRP1,FAM172A,FMO2,
RPL24,IGFBP6,ARHGAP9,UST,MTMR14,RPL37A,STX2,PTEN,FYN,IDH
1,SRPK1,FBXW7,PHPT1,PTP4A2,LGMN,HERPUD1,IKBKB,CTNS,RQC
D1,SNX17,GGNBP2,PXN,KPNB1,SRGAP2,ATP11B,DYM,OXCT1,PARN
,FECH,ERAL1,COX7A2L,WASH4P,ITGB5,TMEM189,NECAB3,FIBP,SS
BP1,CLSTN2,CACNB1,MAPK8,CLTCL1,MYLK,DDX41,MAN1A2,OSBPL
3,HLAF,ABCA2,RAB8A,ZFAND2B,AFF4,SLC35D2,DENND4C,CSK,CDK5RAP
2,COL9A3,OAZ1,PSMC6,TMEM66,STX18,IMPDH1,RNF146,EMC4,DSN
1,CDK6,NSFL1C,AGBL5,WDR61,NUP37,DDHD2,COX14,APPL2,FARSA
,ZNF148,CLTB,FLOT1,PSMC4,ARHGAP29,AAK1,GOPC,RANBP9,PPA2
,ST6GALNAC5,WDR35,ATPAF2,PHKG2,PARD6G,PAK1,NCK2,LEPRO
T,RAB10,RHEB,CTSH,VPS45,ATP6V0A1,ERC1,TIMM50,OS9,P4HB,HS
D17B4,ELOVL1,FUT4,PIWIL4,RPUSD4,TMED3,SS18,SMAD4,GRPEL2,
FNTB,CHURC1FNTB,MEMO1,KLC1,SLC35A4,DDAH1,DTYMK,SLC39A7,EZR,RPL4,MT
RR,CENPT,MBOAT2,AUP1,GOLPH3,TANK,CDCA3,EIF3M,CLK3,DLST,
LRPAP1,MRPL49,FLNA,RAB5A,IRF9,CA5B,SUN2,HGSNAT,MGAT5,BC
S1L,ATP5A1,GLI3,TMED2,ADD3,NDUFV1,MAPK12,NDUFS2,RASGRF2
,AK5,GUSB,MCOLN1,VEZT,B4GALT4,SCFD1,PCSK7,NOX4,ETFA,EXT
1,GAPDH,VTI1B,GAA,MTRF1L,B3GAT3,SLC25A6,PRELID1,SDHA,WW
P1,ARHGEF7,PDIA5,TBCE,VAMP4,REXO2,TRAPPC12,CIRBP,NUP85,I
DH3B,CTTN,NUBP1,RGS2,CLIP2,STAM2,NCBP2,MAN2A2,LPCAT1,PD
G
O:
00
44
46
4
cell part
GFRB,COL8A1,EBPL,VPS51,TGS1,DZIP1,MAN1B1,NIT1,DIABLO,ENO
4
FZD6,MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1
,RAB3GAP2,PLEKHA3,PBX2,LPP,DHX34,KANK2,CRIP2,ACADVL,EIF2
B4,GTF3C2,CADM1,RAI1,PSMB10,XRN1,CKB,CLMN,IGF1R,AVL9,LAM
B1,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,MY
NN,TRNAU1AP,BTN3A1,RAI14,NOC2L,PPIL2,TARS,RAF1,NLRP1,ZNF
131,SEPT5,GP1BB,F11R,TSTD1,LEPRE1,SLC16A3,PPP1R13B,GAS8,
COL9A1,RSC1A1,SFSWAP,CDK13,RBM6,BDNF,TAZ,SIN3B,ATP2B1,S
POP,CPE,CBX5,LDLRAD4,PLCD1,SART1,COL2A1,LRRC1,CCDC91,R
AB34,SUPT5H,SUPT20H,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,GBP3,SHMT2,Z
FP91,CNTF,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLN
S1A,NUP98,EED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,MCF2L,USP4,PP
cell
FIBP2,HDAC6,GLG1,ARHGEF12,EHMT1,ATP6V1D,VRK2,DYNC1I1,RN
ular
H1,ZNF496,HGS,CASP4,DERL2,IL15RA,NARS,LANCL2,H6PD,CD72,S
_co
YTL4,DGKA,TTLL3,ARPC4mpo
TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,HLAnent
C,SUPT4H1,ZNF83,PSMB9,EMX2,ITGA9,ARHGEF25,YIPF1,ADAMTS1,
RGL4,BCL2L13,BCL2L11,RBPMS,XYLT1,GLOD4,STARD13,ZSCAN31,
STARD9,XBP1,COG4,CPM,FDPS,NISCH,PAM,ABCC1,NOM1,CEP135,
GLT8D1,SNRNP70,HSD17B12,DDX23,HLADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,MARK4,UHMK1,USP4
7,ADAM8,MAP7D1,NOL3,POLR3E,CAPZB,GABPB1,PRPF40A,DNAJC1
0,RNF220,RAB35,XAF1,CD9,CDC37L1,PCGF6,RANBP1,SIPA1L1,MAR
CH6,DDX39A,KRIT1,KPNA6,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTP
N6,SUGP1,EEF1A1,ACTR3,LHX4,VASP,CMIP,CSNK2A1,IGBP1,UPF3A
,NOD1,PRKACA,STAT2,ANAPC4,RPP14,PPP1R16A,DHX9,PIGS,PLK1,
APLNR,SDCCAG8,ZNF446,PNPO,VPS52,LMAN2,PDE7B,PREPL,ASNS
,TBC1D2B,COL16A1,ECHDC1,NUTF2,JAG2,TTC19,DNM1L,TXNL1,PT
GES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1,S
1.07
149
236
9
1.
5
9
E
1
3
G
O:
00
cell
cell
ular
_co
HISA5,CCNL1,RHOBTB1,HERC2,CHD6,ZC3H12A,NUP210,TBC1D10B,
SEPT4,MIB2,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,AAMP,RAB24,AT
G4B,SLC26A6,IL13RA1,LSAMP,CNP,CLN8,TBX18,PIGN,GCDH,LBX2,P
CGF1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,ZNF721,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,JAM2,DNPEP,T
BC1D14,GALK2,PRPF3,TNK2,ENGASE,COL14A1,USP20,GIT2,FLG,DC
AF11,WAC,STK11IP,STK4,ZNF142,FUBP3,TRO,MTG1,CCDC14,RARS,
ZNF540,SIKE1,SLC38A2,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR1,H
PS4,RAB18,HSF4,CFB,DISP1,PAIP1,CAPRIN1,GTF3C1,MMP16,ERH,N
ADSYN1,PMS1,ADCY4,CELF1,SNCAIP,PDE4D,SLC4A2,AFAP1,RNAS
ET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,PLEKHG4,SLC9A5,SHARPIN,D
PF2,TCHP,CPT1B,CHKB,NADK,IDI1,RNF8,CDYL2,RUSC2,KIAA0586,C
YP2R1,SEC31A,MDM2,KCMF1,RHBDD1,SNAP23,COL12A1,FKBP1A,Z
FYVE26,PRKCH,DAZAP1,ANAPC16,PPM1F,ZNF595,TBP,DIS3L,IDH3G
,YY1,FAM13A,TLN2,INO80,GPAT2,GMEB2,SSH2,THBS3,MCFD2,PFDN
5,TTC1,CREB1,NPTN,TRAF3IP1,SRP9,RALGPS2,FLII,TNFRSF25,PLE
KHG5,QSOX1,RPRD1A,CCNDBP1,DDX58,ALDH6A1,RPL27,LCP2,CCN
L2,PTPRK,SNX13,DFNA5,AP4B1,RHBDF1,SERPINH1,MAGI1,SNX21,N
F1,ZEB1,PIH1D1,ACAA1,NEK3,EIF4B,CRIP1,REPS1,SERBP1,SETBP1,
SPATS2,NUB1,IFITM3,EMC3,ATG12,NUMA1,TPM4,RGMB,COL18A1,R
TKN,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,NPR1,ZNF3,RPS6KA5,
G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,CAPN10,DCAF8,
GCNT2,ZNF837,PKD2,CASP2,STRN4,SLC12A6,HNRNPA3,RXRB,GAL
T,UBAC1,LMNA,NUDT6,RSL1D1,MITF,NOL8,PPP2R3C,ITGA3,RB1,GO
LGA8B,GOLGA8A,PRMT5,HMGXB3,MAPK8IP3,GNAI1,USP3,PLEKHA2
,STX16,DHRS1,MZF1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,RNF
168,MARK3,PAFAH1B1,ZNF865,LYRM2,SENP2,ISYNA1,EDEM2,GPCP
D1,IL18,RPS19BP1,PUM2,MTCH1,ESAM,SLFN11,CALCOCO2,STARD3
,TPP1,SYTL2
FZD6,MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1
,RAB3GAP2,PLEKHA3,PBX2,LPP,DHX34,KANK2,CRIP2,ACADVL,EIF2
B4,GTF3C2,CADM1,RAI1,PSMB10,XRN1,CKB,CLMN,IGF1R,AVL9,LAM
1.07
141
931
1.
6
6
05
62
3
mpo B1,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,MY
nent NN,TRNAU1AP,BTN3A1,RAI14,NOC2L,PPIL2,TARS,RAF1,NLRP1,ZNF
131,SEPT5,GP1BB,F11R,TSTD1,LEPRE1,SLC16A3,PPP1R13B,GAS8,
COL9A1,RSC1A1,SFSWAP,CDK13,RBM6,BDNF,TAZ,SIN3B,ATP2B1,S
POP,CPE,CBX5,LDLRAD4,PLCD1,SART1,COL2A1,LRRC1,CCDC91,R
AB34,SUPT5H,SUPT20H,RILPL1,HLADPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,LUC7L,BCL6,F
UBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,GBP3,SHMT2,Z
FP91,CNTF,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLN
S1A,NUP98,EED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,MCF2L,USP4,PP
FIBP2,HDAC6,GLG1,ARHGEF12,EHMT1,ATP6V1D,VRK2,DYNC1I1,RN
H1,ZNF496,HGS,CASP4,DERL2,IL15RA,NARS,LANCL2,H6PD,CD72,S
YTL4,DGKA,TTLL3,ARPC4TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,HLAC,SUPT4H1,ZNF83,PSMB9,EMX2,ITGA9,ARHGEF25,YIPF1,ADAMTS1,
RGL4,BCL2L13,BCL2L11,RBPMS,XYLT1,GLOD4,STARD13,ZSCAN31,
STARD9,XBP1,COG4,CPM,FDPS,NISCH,PAM,ABCC1,NOM1,CEP135,
GLT8D1,SNRNP70,HSD17B12,DDX23,HLADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,MARK4,UHMK1,USP4
7,ADAM8,MAP7D1,NOL3,POLR3E,CAPZB,GABPB1,PRPF40A,DNAJC1
0,RNF220,RAB35,XAF1,CD9,CDC37L1,PCGF6,RANBP1,SIPA1L1,MAR
CH6,DDX39A,KRIT1,KPNA6,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,PTP
N6,SUGP1,EEF1A1,ACTR3,LHX4,VASP,CMIP,CSNK2A1,IGBP1,UPF3A
,NOD1,PRKACA,STAT2,ANAPC4,RPP14,PPP1R16A,DHX9,PIGS,PLK1,
APLNR,SDCCAG8,ZNF446,PNPO,VPS52,LMAN2,PDE7B,PREPL,ASNS
,TBC1D2B,COL16A1,ECHDC1,NUTF2,JAG2,TTC19,DNM1L,TXNL1,PT
GES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1,S
HISA5,CCNL1,RHOBTB1,HERC2,CHD6,ZC3H12A,NUP210,TBC1D10B,
SEPT4,MIB2,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,AAMP,RAB24,AT
G4B,SLC26A6,IL13RA1,LSAMP,CNP,CLN8,TBX18,PIGN,GCDH,LBX2,P
CGF1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,ZNF721,HLADMB,ZNF397,JHDM1D,SLC16A1,ZNF710,PLCB4,BBS1,JAM2,DNPEP,T
5
E
1
3
G
O:
00
44
26
7
cellular protein metabolic process
BC1D14,GALK2,PRPF3,TNK2,ENGASE,COL14A1,USP20,GIT2,FLG,DC
AF11,WAC,STK11IP,STK4,ZNF142,FUBP3,TRO,MTG1,CCDC14,RARS,
ZNF540,SIKE1,SLC38A2,ALDH18A1,TPCN2,COPS7B,VTI1A,FGFR1,H
PS4,RAB18,HSF4,CFB,DISP1,PAIP1,CAPRIN1,GTF3C1,MMP16,ERH,N
ADSYN1,PMS1,ADCY4,CELF1,SNCAIP,PDE4D,SLC4A2,AFAP1,RNAS
ET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,PLEKHG4,SLC9A5,SHARPIN,D
PF2,TCHP,CPT1B,CHKB,NADK,IDI1,RNF8,CDYL2,RUSC2,KIAA0586,C
YP2R1,SEC31A,MDM2,KCMF1,RHBDD1,SNAP23,COL12A1,FKBP1A,Z
FYVE26,PRKCH,DAZAP1,ANAPC16,PPM1F,ZNF595,TBP,DIS3L,IDH3G
,YY1,FAM13A,TLN2,INO80,GPAT2,GMEB2,SSH2,THBS3,MCFD2,PFDN
5,TTC1,CREB1,NPTN,TRAF3IP1,SRP9,RALGPS2,FLII,TNFRSF25,PLE
KHG5,QSOX1,RPRD1A,CCNDBP1,DDX58,ALDH6A1,RPL27,LCP2,CCN
L2,PTPRK,SNX13,DFNA5,AP4B1,RHBDF1,SERPINH1,MAGI1,SNX21,N
F1,ZEB1,PIH1D1,ACAA1,NEK3,EIF4B,CRIP1,REPS1,SERBP1,SETBP1,
SPATS2,NUB1,IFITM3,EMC3,ATG12,NUMA1,TPM4,RGMB,COL18A1,R
TKN,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,NPR1,ZNF3,RPS6KA5,
G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,CAPN10,DCAF8,
GCNT2,ZNF837,PKD2,CASP2,STRN4,SLC12A6,HNRNPA3,RXRB,GAL
T,UBAC1,LMNA,NUDT6,RSL1D1,MITF,NOL8,PPP2R3C,ITGA3,RB1,GO
LGA8B,GOLGA8A,PRMT5,HMGXB3,MAPK8IP3,GNAI1,USP3,PLEKHA2
,STX16,DHRS1,MZF1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,RNF
168,MARK3,PAFAH1B1,ZNF865,LYRM2,SENP2,ISYNA1,EDEM2,GPCP
D1,IL18,RPS19BP1,PUM2,MTCH1,ESAM,SLFN11,CALCOCO2,STARD3
,TPP1,SYTL2
CDK14,USP10,CRBN,ACADVL,EIF2B4,PSMB10,IGF1R,TNRC6A,SIRT2
,TRNAU1AP,NOC2L,PPIL2,TARS,RAF1,CDK13,SPOP,CPE,ST3GAL1,M
biol
ARCH5,UBXN1,FBXO32,PTPN22,ZFP91,CNTF,EEF2K,VAPB,GPAA1,E
ogic
ED,FMR1,SMAD7,USP4,HDAC6,EHMT1,VRK2,DERL2,NARS,TTLL3,PR
al_p
MT10,LEF1,PSMB9,RBPMS,XBP1,PAM,RAD23A,APITD1,MPDU1,MAR
roce
K4,UHMK1,USP47,ADAM8,DNAJC10,RNF220,MARCH6,MINK1,PTPN6,
ss
EEF1A1,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,ANAPC4,PIGS,PLK1,
ASNS,JAG2,UPF1,HDGF,RC3H1,PPP5C,PIGG,NPC1,CCNL1,HERC2,S
1.39
189
465
4
2.
0
6
E
1
3
EPT4,MIB2,SYMPK,FAM58A,CLN8,PIGN,PCGF1,DR1,CAMK2D,JHDM1
D,GIGYF2,TNK2,USP20,DCAF11,WAC,STK4,RARS,ZNF540,COPS7B,F
GFR1,HSF4,PAIP1,CAPRIN1,ADCY4,CELF1,TIMM23,PAF1,TAB2,SGK1
,SHARPIN,RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,PRKCH,ANAPC16,
PPM1F,SSH2,MCFD2,PFDN5,TTC1,CREB1,NPTN,SRP9,QSOX1,RPRD
1A,RPL27,CCNL2,PTPRK,RHBDF1,NF1,NEK3,EIF4B,NUB1,SPSB3,RP
L9,PHF15,FKBP10,UNKL,NPR1,RPS6KA5,NIPBL,ALG6,ST3GAL4,DCA
F8,GCNT2,PKD2,UBE2Q1,MDP1,UBAC1,LMNA,RSL1D1,USP24,RB1,P
RMT5,LTBP4,MAPK8IP3,RABGGTA,USP3,RNF168,MARK3,SENP2,ED
EM2,PUM2,RNF217,TPP1,STK38L,GALNT2,SH3BP5,USP33,NTMT1,R
GS3,NR1H3,GARS,MRPS7,PLK2,PAN2,USP7,FLCN,NRP1,CUL4A,CHF
R,RPL24,UST,MTMR14,RPL37A,MAST2,PTEN,FYN,SRPK1,IQGAP1,FB
XW7,PHPT1,PTP4A2,HERPUD1,IKBKB,PXN,PTPRF,NCOR1,FECH,PR
KRIP1,SETD8,SMEK1,STK19,PIAS2,MAPK8,MYCBP2,MYLK,USP15,M
AN1A2,RNF213,N6AMT1,TRIM28,MAP4K4,CSK,PTPRS,PTPRC,PSMC
6,TBCD,RNF146,CDK6,AGBL5,WDR61,FARSA,PSMC4,UBA2,AAK1,PP
A2,ST6GALNAC5,PHKG2,PAK1,NCK2,TRPM7,SEMA4D,CSF1R,ERC1,
TIMM50,OS9,C3,NFYC,P4HB,FUT4,PIWIL4,SMAD4,GRPEL2,FNTB,CH
URC1FNTB,TGFB1I1,ASB8,RPL4,ING4,USP54,CDCA3,EIF3M,CDC14B,CLK3
,LRPAP1,MRPL49,MSL1,MGAT5,MAPK12,DCAF6,AK5,B4GALT4,ENG,
SIRT7,ARNT,NOX4,EXT1,GAPDH,PHF1,MTRF1L,NRBP2,B3GAT3,SLC
25A6,STK36,WWP1,PDIA5,TBCE,MDFI,CIRBP,UBA6,RABGGTB,NAA1
0,PTPRD,ITGA5,RGS2,NCBP2,MAN2A2,PDGFRB,PTPN4,CDK11A,MA
N1B1,CARD14,TNFRSF14,CANX,MKNK2,TRIM41,SMARCA4,NAA16,U
SP40,YIF1A,RPLP0,SUMF2,PTPN23,CLK4,TLN1,DCAF17,ADRBK2,KL
HL7,DNAJC21,GSK3A,SIK3,MRPL3,TTLL11,FBXW2,SETD2,TWF1,KAN
SL3,PIGO,PDIA3,PRPF4B,IGF2,D2HGDH,ATXN3,AMFR,PSTK,GPHN,P
DCD4,CRIPAK,LONP2,PSMA1,CARS2,CSNK1E,CDK5RAP1,NTRK1,SH
PRH,SPRED1,TNFRSF10B,PHKG1,ATG3,SMAD9,LMF1,DUSP6,TGFB
R3,ZBTB16,BAZ2A,SIRT3,PLOD2,SPCS3,PPT2,EGFL8,EIF3I,VARS,LA
RS,PHF19,SENP6,PKD1,PDPK1,TSG101,STK24,HEMK1,SSH1,CDK5R
G
O:
00
70
01
3
intracellular organelle lumen
AP3,GAK,ALG9,PABPC1,UBR5,FASTK,EYA2,SMARCAD1,WNK1,GATA
2
RNASEH2B,CRBN,OBFC1,PBX2,ACADVL,GTF3C2,PSMB10,EPHX2,U
TRN,NOC2L,PPIL2,LEPRE1,PPP1R13B,COL9A1,RSC1A1,CDK13,SIN3
B,CBX5,SART1,COL2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,B
CL6,FUBP1,CMPK2,TBX2,MMS19,SHMT2,ZFP91,CUX1,RBM17,NUP98
,EED,FMR1,SMAD7,HDAC6,ZNF496,H6PD,SYTL4,PNKP,LEF1,GLS,PA
X8,SUPT4H1,PSMB9,XBP1,CPM,FDPS,ABCC1,NOM1,SNRNP70,DDX2
3,METTL3,APITD1,NOL3,POLR3E,PRPF40A,DNAJC10,SUGP1,CSNK2
A1,UPF3A,STAT2,ANAPC4,DHX9,PLK1,COL16A1,HDGF,FDXR,PDXK,
CCNL1,ZC3H12A,SEPT4,SYMPK,EFTUD2,GCDH,PCGF1,DR1,BCLAF1
,CAMK2D,FYTTD1,JHDM1D,PRPF3,COL14A1,GIT2,WAC,MTG1,RARS,
GTF3C1,MMP16,SNCAIP,RNASET2,SF3A2,PAF1,DPF2,MDM2,SNAP2
3,COL12A1,DAZAP1,TBP,IDH3G,YY1,INO80,GMEB2,CREB1,FLII,RPR
D1A,ALDH6A1,CCNL2,SERPINH1,ZEB1,ACAA1,NUMA1,COL18A1,RPL
cell
9,MED28,PHF15,FKBP10,ZNF3,RPS6KA5,ALKBH3,HNRNPA3,RXRB,L
ular
MNA,RSL1D1,NOL8,RB1,USP3,STX16,ZFPM2,TP53BP1,TXNDC5,PAF
_co
AH1B1,SENP2,EDEM2,RPS19BP1,CALCOCO2,TPP1,SUB1,PWP2,CH
mpo
MP1A,NSA2,SYNE1,STK38L,ZNF263,NTMT1,NR1H3,GARS,HEXA,USP
nent
7,CHFR,SAP30BP,PTEN,IDH1,SRPK1,RUNX2,CSTF1,IQGAP1,FBXW7,
INTS4,LGMN,SMARCD3,KPNB1,NCOR1,MEF2A,OXCT1,PARN,FECH,
ERAL1,PRKRIP1,PIAS2,SSBP1,MAPK8,DDX41,MAN1A2,SRRM2,PBX3,
AFF4,TRIM28,DMTF1,COL9A3,PSMC6,RPF2,SKIV2L2,WDR61,PRPF8,
APPL2,ZNF148,WDR13,PSMC4,HNRNPL,STAG2,SP110,PPA2,ATPAF2
,HNRNPH3,TCF4,ACD,WDR4,ATP6V0A1,TIMM50,OS9,DGKZ,NFYC,P4
HB,HSD17B4,SRSF10,SMAD4,GRPEL2,TGFB1I1,INO80E,DTYMK,EZR,
RPL4,MTRR,ZNF44,AUP1,ING4,ZNF687,CDC14B,CLK3,NR2C2,FIP1L1
,DLST,DNTTIP2,LRPAP1,MRPL49,IRF9,CA5B,SUN2,MSL1,ATP5A1,GLI
3,ADD3,MAPK12,GUSB,ENG,SIRT7,TCF12,ARNT,ETFA,ERCC1,PHF1,
PRELID1,PHF12,PDIA5,REXO2,MED6,CIRBP,IDH3B,RGS2,HINFP,STA
M2,NCBP2,PDGFRB,COL8A1,TGS1,NCAPD3,RAD51B,FAM76B,BDP1,
DBF4,CANX,RUNX1,MKNK2,SMARCA4,LMNB1,NAA16,LRPPRC,SUMF
1.41
034
447
6
1.
4
6
E
1
2
G
O:
00
19
53
8
protein metabolic process
2,SDAD1,SNX27,ZNF638,DCAF17,KLHL7,SNRPE,POLG,MRPL3,NCOR
2,FPGS,KANSL3,PDIA3,PRPF4B,COL13A1,FTSJ3,NARF,TROVE2,D2H
GDH,ATXN3,MAU2,PHF21A,PDCD4,LONP2,PSMA1,STAT6,CARS2,ACI
N1,SON,CLIC4,BTBD10,TFAM,PNISR,SPRED1,BRWD1,SMAD9,DUSP
6,ZBTB16,BAZ2A,SIRT3,KDELC2,RRP8,PHF19,SEPT2,LUC7L3,CES2,
SENP6,PDPK1,TSG101,USF1,FOXC1,KPNA1,ZC3H14,ACAN,STK24,F
MOD,PHC2,SMARCAD1,SYCP2L,ZC3H15,GATA2,PABPN1
CDK14,USP10,CRBN,ACADVL,EIF2B4,PSMB10,IGF1R,TNRC6A,SIRT2
,TRNAU1AP,NOC2L,PPIL2,TARS,RAF1,GP1BB,DDI2,CDK13,SPOP,CP
E,COL2A1,ST3GAL1,MARCH5,UBXN1,DPP4,FBXO32,PTPN22,ZFP91,
CNTF,EEF2K,VAPB,NLN,GPAA1,EED,FMR1,SMAD7,USP4,HDAC6,GL
G1,EHMT1,VRK2,HGS,CASP4,DERL2,NARS,TTLL3,PRMT10,LEF1,PS
MB9,ADAMTS1,RBPMS,XYLT1,XBP1,CPM,PAM,RAD23A,SCRN3,APIT
D1,MPDU1,MARK4,UHMK1,USP47,ADAM8,DNAJC10,RNF220,MARCH
6,MINK1,PTPN6,EEF1A1,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,AN
APC4,PIGS,PLK1,PREPL,ASNS,JAG2,UPF1,HDGF,RC3H1,PPP5C,PIG
G,NPC1,CCNL1,HERC2,SEPT4,MIB2,SYMPK,FAM58A,ATG4B,CLN8,PI
biol GN,PCGF1,DR1,CAMK2D,JHDM1D,GIGYF2,DNPEP,TNK2,USP20,DCA
ogic F11,WAC,STK4,RARS,ZNF540,COPS7B,FGFR1,HSF4,C2,CFB,DISP1,
al_p PAIP1,CAPRIN1,MMP16,ADCY4,CELF1,TIMM23,PAF1,TAB2,SGK1,SH
roce ARPIN,RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,PRKCH,ANAPC16,PP
ss
M1F,SSH2,MCFD2,PFDN5,TTC1,CREB1,NPTN,SRP9,QSOX1,RPRD1A
,RPL27,CCNL2,PTPRK,RHBDF1,SERPINH1,NF1,NEK3,EIF4B,NUB1,S
PSB3,RPL9,PHF15,FKBP10,UNKL,NPR1,RPS6KA5,NIPBL,ALG6,ST3G
AL4,CAPN10,DCAF8,GCNT2,PKD2,CASP2,UBE2Q1,MDP1,UBAC1,LM
NA,RSL1D1,USP24,RB1,PRMT5,LTBP4,MAPK8IP3,RABGGTA,USP3,R
NF168,MARK3,SENP2,EDEM2,IL18,PUM2,RNF217,TPP1,STK38L,GAL
NT2,ADAM15,SH3BP5,USP33,NTMT1,RGS3,NR1H3,GARS,MRPS7,PL
K2,PAN2,HEXA,USP7,FLCN,NRP1,CUL4A,CHFR,RPL24,UST,MTMR14,
RPL37A,MAST2,FAP,PTEN,FYN,SRPK1,IQGAP1,C1R,FBXW7,PHPT1,
PTP4A2,LGMN,HERPUD1,IFT172,IKBKB,PXN,ADAMTS18,PTPRF,NCO
R1,FECH,PRKRIP1,SETD8,SMEK1,STK19,NECAB3,PIAS2,MAPK8,MY
1.32
470
826
5
4.
7
9
E
1
2
G
O:
00
43
41
2
macromolecule modification
CBP2,MYLK,USP15,MAN1A2,RNF213,N6AMT1,TRIM28,MAP4K4,CSK,
PTPRS,PTPRC,PSMC6,TBCD,RNF146,CDK6,AGBL5,WDR61,FARSA,P
SMC4,SGSM3,UBA2,AAK1,PPA2,ST6GALNAC5,PHKG2,PAK1,NCK2,C
TSH,TRPM7,SEMA4D,CSF1R,ERC1,TIMM50,OS9,C3,NFYC,P4HB,FUT
4,PIWIL4,SMAD4,GRPEL2,FNTB,CHURC1FNTB,TGFB1I1,ASB8,RPL4,ING4,USP54,CD276,CDCA3,EIF3M,CDC14
B,CLK3,LRPAP1,APOL3,MRPL49,FLNA,IRF9,MSL1,MGAT5,C1S,GLI3,
MAPK12,DCAF6,AK5,B4GALT4,ENG,SIRT7,PCSK7,ARNT,NOX4,EXT1,
GAPDH,PHF1,MTRF1L,NRBP2,B3GAT3,SLC25A6,STK36,WWP1,PDIA
5,TBCE,MDFI,CIRBP,UBA6,RABGGTB,NAA10,PTPRD,ITGA5,RGS2,NC
BP2,MAN2A2,LPCAT1,PDGFRB,PTPN4,CDK11A,MAN1B1,CARD14,TN
FRSF14,CANX,MKNK2,TRIM41,SMARCA4,NAA16,USP40,YIF1A,RPLP
0,SUMF2,PTPN23,RHBDF2,CLK4,TLN1,DCAF17,ADRBK2,KLHL7,DNAJ
C21,LONRF3,GSK3A,SIK3,MRPL3,TTLL11,FBXW2,SETD2,TWF1,ATG4
A,KANSL3,PIGO,PDIA3,PRPF4B,IGF2,D2HGDH,ATXN3,DPP7,AMFR,P
STK,GPHN,PDCD4,CRIPAK,LONP2,PSMA1,CARS2,CSNK1E,CDK5RA
P1,NTRK1,SHPRH,SPRED1,TNFRSF10B,PHKG1,ATG3,SMAD9,LMF1,
DUSP6,TGFBR3,ZBTB16,STAMBPL1,BAZ2A,SIRT3,PLOD2,SPCS3,PP
T2,EGFL8,EIF3I,VARS,LARS,PHF19,SENP6,PKD1,PDPK1,TSG101,AC
AN,STK24,HEMK1,SSH1,CDK5RAP3,GAK,C2CD3,ALG9,PABPC1,MMP
25,UBR5,FASTK,EYA2,SMARCAD1,WNK1,GATA2
CDK14,USP10,CRBN,ACADVL,PSMB10,IGF1R,SIRT2,NOC2L,PPIL2,R
AF1,CDK13,SPOP,CPE,ST3GAL1,MARCH5,UBXN1,FBXO32,PTPN22,Z
FP91,CNTF,EEF2K,VAPB,GPAA1,EED,SMAD7,USP4,HDAC6,EHMT1,V
biol RK2,TTLL3,PRMT10,LEF1,PSMB9,RBPMS,XBP1,PAM,METTL3,APITD1
ogic ,MARK4,UHMK1,USP47,ADAM8,DNAJC10,RNF220,MARCH6,MINK1,P
al_p TPN6,CSNK2A1,IGBP1,NOD1,PRKACA,ANAPC4,PIGS,PLK1,ASNS,HD
roce GF,RC3H1,PPP5C,PIGG,NPC1,CCNL1,HERC2,SEPT4,MIB2,SYMPK,F
ss
AM58A,PIGN,PCGF1,DR1,CAMK2D,JHDM1D,TNK2,USP20,DCAF11,W
AC,STK4,COPS7B,FGFR1,HSF4,ADCY4,PAF1,TAB2,SGK1,SHARPIN,
RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,PRKCH,ANAPC16,PPM1F,SS
H2,MCFD2,CREB1,NPTN,RPRD1A,CCNL2,PTPRK,NF1,NEK3,NUB1,S
1.41
503
855
9
6.
7
7
E
1
2
G
O:
00
06
46
4
cellular protein modification process
PSB3,PHF15,FKBP10,UNKL,NPR1,RPS6KA5,NIPBL,ALKBH3,ALG6,ST
3GAL4,DCAF8,GCNT2,PKD2,UBE2Q1,MDP1,UBAC1,LMNA,RB1,PRMT
5,LTBP4,MAPK8IP3,RABGGTA,USP3,RNF168,MARK3,SENP2,EDEM2,
RNF217,TPP1,STK38L,GALNT2,SH3BP5,USP33,NTMT1,RGS3,PLK2,U
SP7,PLD6,FLCN,NRP1,CUL4A,CHFR,UST,MTMR14,MAST2,PTEN,FYN
,SRPK1,IQGAP1,FBXW7,PHPT1,PTP4A2,HERPUD1,IKBKB,PXN,PTPR
F,NCOR1,PARN,FECH,PRKRIP1,SETD8,SMEK1,STK19,PIAS2,MAPK8,
MYCBP2,MYLK,USP15,MAN1A2,RNF213,N6AMT1,TRIM28,MAP4K4,C
SK,PTPRS,PTPRC,PSMC6,RNF146,CDK6,AGBL5,WDR61,PSMC4,UBA
2,AAK1,ST6GALNAC5,PHKG2,PAK1,NCK2,TRPM7,WDR4,SEMA4D,CS
F1R,ERC1,TIMM50,OS9,C3,P4HB,FUT4,PIWIL4,RPUSD4,SMAD4,FNT
B,CHURC1FNTB,ASB8,ING4,CDCA3,CDC14B,CLK3,MSL1,MGAT5,MAPK12,DCAF
6,AK5,B4GALT4,ENG,SIRT7,ARNT,NOX4,EXT1,GAPDH,PHF1,NRBP2,
B3GAT3,STK36,WWP1,PDIA5,MDFI,UBA6,RABGGTB,NAA10,PTPRD,I
TGA5,RGS2,MAN2A2,PDGFRB,PTPN4,TGS1,CDK11A,MAN1B1,CARD
14,TNFRSF14,CANX,MKNK2,TRIM41,SMARCA4,NAA16,YIF1A,SUMF2,
PTPN23,CLK4,TLN1,DCAF17,ADRBK2,KLHL7,GSK3A,SIK3,TTLL11,FB
XW2,SETD2,TWF1,KANSL3,PIGO,PDIA3,PRPF4B,IGF2,FTSJ3,ATXN3,
AMFR,PDCD4,CRIPAK,PSMA1,CSNK1E,CDK5RAP1,NTRK1,SHPRH,S
PRED1,TNFRSF10B,PHKG1,ATG3,SMAD9,LMF1,DUSP6,TGFBR3,ZBT
B16,BAZ2A,SIRT3,PLOD2,PPT2,EGFL8,PHF19,SENP6,PKD1,PDPK1,T
SG101,STK24,HEMK1,SSH1,CDK5RAP3,GAK,MTO1,ALG9,UBR5,FAST
K,EYA2,SMARCAD1,WNK1,GATA2
CDK14,USP10,CRBN,ACADVL,PSMB10,IGF1R,SIRT2,NOC2L,PPIL2,R
AF1,CDK13,SPOP,CPE,ST3GAL1,MARCH5,UBXN1,FBXO32,PTPN22,Z
biol
FP91,CNTF,EEF2K,VAPB,GPAA1,EED,SMAD7,USP4,HDAC6,EHMT1,V
ogic
RK2,TTLL3,PRMT10,LEF1,PSMB9,RBPMS,XBP1,PAM,APITD1,MARK4,
al_p
UHMK1,USP47,ADAM8,DNAJC10,RNF220,MARCH6,MINK1,PTPN6,CS
roce
NK2A1,IGBP1,NOD1,PRKACA,ANAPC4,PIGS,PLK1,ASNS,HDGF,RC3H
ss
1,PPP5C,PIGG,NPC1,CCNL1,HERC2,SEPT4,MIB2,SYMPK,FAM58A,PI
GN,PCGF1,DR1,CAMK2D,JHDM1D,TNK2,USP20,DCAF11,WAC,STK4,
1.42
595
296
1
6.
9
9
E
1
2
G
O:
00
36
21
1
protein modification process
COPS7B,FGFR1,HSF4,ADCY4,PAF1,TAB2,SGK1,SHARPIN,RNF8,SEC
31A,MDM2,RHBDD1,FKBP1A,PRKCH,ANAPC16,PPM1F,SSH2,MCFD2,
CREB1,NPTN,RPRD1A,CCNL2,PTPRK,NF1,NEK3,NUB1,SPSB3,PHF1
5,FKBP10,UNKL,NPR1,RPS6KA5,NIPBL,ALG6,ST3GAL4,DCAF8,GCNT
2,PKD2,UBE2Q1,MDP1,UBAC1,LMNA,RB1,PRMT5,LTBP4,MAPK8IP3,
RABGGTA,USP3,RNF168,MARK3,SENP2,EDEM2,RNF217,TPP1,STK3
8L,GALNT2,SH3BP5,USP33,NTMT1,RGS3,PLK2,USP7,FLCN,NRP1,CU
L4A,CHFR,UST,MTMR14,MAST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,P
HPT1,PTP4A2,HERPUD1,IKBKB,PXN,PTPRF,NCOR1,FECH,PRKRIP1,
SETD8,SMEK1,STK19,PIAS2,MAPK8,MYCBP2,MYLK,USP15,MAN1A2,
RNF213,N6AMT1,TRIM28,MAP4K4,CSK,PTPRS,PTPRC,PSMC6,RNF1
46,CDK6,AGBL5,WDR61,PSMC4,UBA2,AAK1,ST6GALNAC5,PHKG2,P
AK1,NCK2,TRPM7,SEMA4D,CSF1R,ERC1,TIMM50,OS9,C3,P4HB,FUT
4,SMAD4,FNTB,CHURC1FNTB,ASB8,ING4,CDCA3,CDC14B,CLK3,MSL1,MGAT5,MAPK12,DCAF
6,AK5,B4GALT4,ENG,SIRT7,ARNT,NOX4,EXT1,GAPDH,PHF1,NRBP2,
B3GAT3,STK36,WWP1,PDIA5,MDFI,UBA6,RABGGTB,NAA10,PTPRD,I
TGA5,RGS2,MAN2A2,PDGFRB,PTPN4,CDK11A,MAN1B1,CARD14,TN
FRSF14,CANX,MKNK2,TRIM41,SMARCA4,NAA16,YIF1A,SUMF2,PTPN
23,CLK4,TLN1,DCAF17,ADRBK2,KLHL7,GSK3A,SIK3,TTLL11,FBXW2,
SETD2,TWF1,KANSL3,PIGO,PDIA3,PRPF4B,IGF2,ATXN3,AMFR,PDCD
4,CRIPAK,PSMA1,CSNK1E,CDK5RAP1,NTRK1,SHPRH,SPRED1,TNFR
SF10B,PHKG1,ATG3,SMAD9,LMF1,DUSP6,TGFBR3,ZBTB16,BAZ2A,SI
RT3,PLOD2,PPT2,EGFL8,PHF19,SENP6,PKD1,PDPK1,TSG101,STK24,
HEMK1,SSH1,CDK5RAP3,GAK,ALG9,UBR5,FASTK,EYA2,SMARCAD1,
WNK1,GATA2
CDK14,USP10,CRBN,ACADVL,PSMB10,IGF1R,SIRT2,NOC2L,PPIL2,R
biol
AF1,CDK13,SPOP,CPE,ST3GAL1,MARCH5,UBXN1,FBXO32,PTPN22,Z
ogic
FP91,CNTF,EEF2K,VAPB,GPAA1,EED,SMAD7,USP4,HDAC6,EHMT1,V
al_p
RK2,TTLL3,PRMT10,LEF1,PSMB9,RBPMS,XBP1,PAM,APITD1,MARK4,
roce
UHMK1,USP47,ADAM8,DNAJC10,RNF220,MARCH6,MINK1,PTPN6,CS
ss
NK2A1,IGBP1,NOD1,PRKACA,ANAPC4,PIGS,PLK1,ASNS,HDGF,RC3H
1.42
595
296
1
6.
9
9
E
1
G
O:
00
31
membrane-enclosed lumen
1,PPP5C,PIGG,NPC1,CCNL1,HERC2,SEPT4,MIB2,SYMPK,FAM58A,PI
GN,PCGF1,DR1,CAMK2D,JHDM1D,TNK2,USP20,DCAF11,WAC,STK4,
COPS7B,FGFR1,HSF4,ADCY4,PAF1,TAB2,SGK1,SHARPIN,RNF8,SEC
31A,MDM2,RHBDD1,FKBP1A,PRKCH,ANAPC16,PPM1F,SSH2,MCFD2,
CREB1,NPTN,RPRD1A,CCNL2,PTPRK,NF1,NEK3,NUB1,SPSB3,PHF1
5,FKBP10,UNKL,NPR1,RPS6KA5,NIPBL,ALG6,ST3GAL4,DCAF8,GCNT
2,PKD2,UBE2Q1,MDP1,UBAC1,LMNA,RB1,PRMT5,LTBP4,MAPK8IP3,
RABGGTA,USP3,RNF168,MARK3,SENP2,EDEM2,RNF217,TPP1,STK3
8L,GALNT2,SH3BP5,USP33,NTMT1,RGS3,PLK2,USP7,FLCN,NRP1,CU
L4A,CHFR,UST,MTMR14,MAST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,P
HPT1,PTP4A2,HERPUD1,IKBKB,PXN,PTPRF,NCOR1,FECH,PRKRIP1,
SETD8,SMEK1,STK19,PIAS2,MAPK8,MYCBP2,MYLK,USP15,MAN1A2,
RNF213,N6AMT1,TRIM28,MAP4K4,CSK,PTPRS,PTPRC,PSMC6,RNF1
46,CDK6,AGBL5,WDR61,PSMC4,UBA2,AAK1,ST6GALNAC5,PHKG2,P
AK1,NCK2,TRPM7,SEMA4D,CSF1R,ERC1,TIMM50,OS9,C3,P4HB,FUT
4,SMAD4,FNTB,CHURC1FNTB,ASB8,ING4,CDCA3,CDC14B,CLK3,MSL1,MGAT5,MAPK12,DCAF
6,AK5,B4GALT4,ENG,SIRT7,ARNT,NOX4,EXT1,GAPDH,PHF1,NRBP2,
B3GAT3,STK36,WWP1,PDIA5,MDFI,UBA6,RABGGTB,NAA10,PTPRD,I
TGA5,RGS2,MAN2A2,PDGFRB,PTPN4,CDK11A,MAN1B1,CARD14,TN
FRSF14,CANX,MKNK2,TRIM41,SMARCA4,NAA16,YIF1A,SUMF2,PTPN
23,CLK4,TLN1,DCAF17,ADRBK2,KLHL7,GSK3A,SIK3,TTLL11,FBXW2,
SETD2,TWF1,KANSL3,PIGO,PDIA3,PRPF4B,IGF2,ATXN3,AMFR,PDCD
4,CRIPAK,PSMA1,CSNK1E,CDK5RAP1,NTRK1,SHPRH,SPRED1,TNFR
SF10B,PHKG1,ATG3,SMAD9,LMF1,DUSP6,TGFBR3,ZBTB16,BAZ2A,SI
RT3,PLOD2,PPT2,EGFL8,PHF19,SENP6,PKD1,PDPK1,TSG101,STK24,
HEMK1,SSH1,CDK5RAP3,GAK,ALG9,UBR5,FASTK,EYA2,SMARCAD1,
WNK1,GATA2
cell RNASEH2B,CRBN,OBFC1,PBX2,ACADVL,GTF3C2,PSMB10,EPHX2,U
ular TRN,NOC2L,PPIL2,LEPRE1,PPP1R13B,COL9A1,RSC1A1,CDK13,SIN3
_co B,CBX5,SART1,COL2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,B
mpo CL6,FUBP1,CMPK2,TBX2,MMS19,SHMT2,ZFP91,NLN,CUX1,RBM17,N
2
1.38
780
207
8
8.
4
6
E
97
4
nent
UP98,EED,FMR1,SMAD7,HDAC6,ZNF496,H6PD,SYTL4,PNKP,LEF1,GL
S,PAX8,SUPT4H1,PSMB9,XBP1,CPM,FDPS,ABCC1,NOM1,SNRNP70,
DDX23,METTL3,APITD1,NOL3,POLR3E,PRPF40A,DNAJC10,SUGP1,C
SNK2A1,UPF3A,STAT2,ANAPC4,DHX9,PLK1,COL16A1,HDGF,FDXR,P
DXK,CCNL1,ZC3H12A,SEPT4,SYMPK,EFTUD2,GCDH,PCGF1,DR1,BC
LAF1,CAMK2D,FYTTD1,JHDM1D,PRPF3,COL14A1,GIT2,WAC,MTG1,R
ARS,GTF3C1,MMP16,SNCAIP,RNASET2,SF3A2,TIMM23,PAF1,DPF2,
MDM2,SNAP23,COL12A1,DAZAP1,TBP,IDH3G,YY1,INO80,GMEB2,CR
EB1,FLII,RPRD1A,ALDH6A1,CCNL2,SERPINH1,ZEB1,ACAA1,NUMA1,
COL18A1,RPL9,MED28,PHF15,FKBP10,ZNF3,RPS6KA5,ALKBH3,HNR
NPA3,RXRB,LMNA,RSL1D1,NOL8,RB1,USP3,STX16,ZFPM2,TP53BP1,
TXNDC5,PAFAH1B1,SENP2,EDEM2,RPS19BP1,CALCOCO2,TPP1,SU
B1,PWP2,CHMP1A,NSA2,SYNE1,STK38L,ZNF263,NTMT1,NR1H3,GAR
S,HEXA,USP7,CHFR,SAP30BP,PTEN,IDH1,SRPK1,RUNX2,CSTF1,IQG
AP1,FBXW7,INTS4,LGMN,SMARCD3,KPNB1,NCOR1,MEF2A,OXCT1,P
ARN,FECH,ERAL1,PRKRIP1,PIAS2,SSBP1,MAPK8,DDX41,MAN1A2,S
RRM2,PBX3,AFF4,TRIM28,DMTF1,COL9A3,PSMC6,RPF2,SKIV2L2,WD
R61,PRPF8,APPL2,ZNF148,WDR13,PSMC4,HNRNPL,STAG2,SP110,P
PA2,ATPAF2,HNRNPH3,TCF4,ACD,WDR4,ATP6V0A1,TIMM50,OS9,DG
KZ,NFYC,P4HB,HSD17B4,SRSF10,SMAD4,GRPEL2,TGFB1I1,INO80E,
DTYMK,EZR,RPL4,MTRR,ZNF44,AUP1,GOLPH3,ING4,ZNF687,CDC14
B,CLK3,NR2C2,FIP1L1,DLST,DNTTIP2,LRPAP1,MRPL49,IRF9,CA5B,S
UN2,MSL1,ATP5A1,GLI3,ADD3,MAPK12,GUSB,ENG,SIRT7,TCF12,AR
NT,ETFA,ERCC1,PHF1,PRELID1,PHF12,PDIA5,REXO2,MED6,CIRBP,I
DH3B,RGS2,HINFP,STAM2,NCBP2,PDGFRB,COL8A1,TGS1,NCAPD3,
RAD51B,FAM76B,BDP1,DIABLO,DBF4,CANX,RUNX1,MKNK2,SMARC
A4,LMNB1,NAA16,LRPPRC,SUMF2,SDAD1,SNX27,ZNF638,DCAF17,K
LHL7,SNRPE,POLG,MRPL3,NCOR2,FPGS,KANSL3,PDIA3,PRPF4B,C
OL13A1,FTSJ3,NARF,TROVE2,D2HGDH,ATXN3,MAU2,PHF21A,PDCD
4,LONP2,PSMA1,STAT6,CARS2,ACIN1,SON,CLIC4,BTBD10,TFAM,PNI
SR,SPRED1,BRWD1,SMAD9,DUSP6,ZBTB16,BAZ2A,SIRT3,KDELC2,R
RP8,PHF19,SEPT2,LUC7L3,CES2,SENP6,PDPK1,TSG101,USF1,FOXC
1
2
G
O:
00
43
23
3
organelle lumen
1,KPNA1,ZC3H14,ACAN,STK24,FMOD,PHC2,SMARCAD1,SYCP2L,ZC
3H15,GATA2,PABPN1
RNASEH2B,CRBN,OBFC1,PBX2,ACADVL,GTF3C2,PSMB10,EPHX2,U
TRN,NOC2L,PPIL2,LEPRE1,PPP1R13B,COL9A1,RSC1A1,CDK13,SIN3
B,CBX5,SART1,COL2A1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,B
CL6,FUBP1,CMPK2,TBX2,MMS19,SHMT2,ZFP91,CUX1,RBM17,NUP98
,EED,FMR1,SMAD7,HDAC6,ZNF496,H6PD,SYTL4,PNKP,LEF1,GLS,PA
X8,SUPT4H1,PSMB9,XBP1,CPM,FDPS,ABCC1,NOM1,SNRNP70,DDX2
3,METTL3,APITD1,NOL3,POLR3E,PRPF40A,DNAJC10,SUGP1,CSNK2
A1,UPF3A,STAT2,ANAPC4,DHX9,PLK1,COL16A1,HDGF,FDXR,PDXK,
CCNL1,ZC3H12A,SEPT4,SYMPK,EFTUD2,GCDH,PCGF1,DR1,BCLAF1
,CAMK2D,FYTTD1,JHDM1D,PRPF3,COL14A1,GIT2,WAC,MTG1,RARS,
GTF3C1,MMP16,SNCAIP,RNASET2,SF3A2,PAF1,DPF2,MDM2,SNAP2
3,COL12A1,DAZAP1,TBP,IDH3G,YY1,INO80,GMEB2,CREB1,FLII,RPR
D1A,ALDH6A1,CCNL2,SERPINH1,ZEB1,ACAA1,NUMA1,COL18A1,RPL
cell
9,MED28,PHF15,FKBP10,ZNF3,RPS6KA5,ALKBH3,HNRNPA3,RXRB,L
ular
MNA,RSL1D1,NOL8,RB1,USP3,STX16,ZFPM2,TP53BP1,TXNDC5,PAF
_co
AH1B1,SENP2,EDEM2,RPS19BP1,CALCOCO2,TPP1,SUB1,PWP2,CH
mpo
MP1A,NSA2,SYNE1,STK38L,ZNF263,NTMT1,NR1H3,GARS,HEXA,USP
nent
7,CHFR,SAP30BP,PTEN,IDH1,SRPK1,RUNX2,CSTF1,IQGAP1,FBXW7,
INTS4,LGMN,SMARCD3,KPNB1,NCOR1,MEF2A,OXCT1,PARN,FECH,
ERAL1,PRKRIP1,PIAS2,SSBP1,MAPK8,DDX41,MAN1A2,SRRM2,PBX3,
AFF4,TRIM28,DMTF1,COL9A3,PSMC6,RPF2,SKIV2L2,WDR61,PRPF8,
APPL2,ZNF148,WDR13,PSMC4,HNRNPL,STAG2,SP110,PPA2,ATPAF2
,HNRNPH3,TCF4,ACD,WDR4,ATP6V0A1,TIMM50,OS9,DGKZ,NFYC,P4
HB,HSD17B4,SRSF10,SMAD4,GRPEL2,TGFB1I1,INO80E,DTYMK,EZR,
RPL4,MTRR,ZNF44,AUP1,ING4,ZNF687,CDC14B,CLK3,NR2C2,FIP1L1
,DLST,DNTTIP2,LRPAP1,MRPL49,IRF9,CA5B,SUN2,MSL1,ATP5A1,GLI
3,ADD3,MAPK12,GUSB,ENG,SIRT7,TCF12,ARNT,ETFA,ERCC1,PHF1,
PRELID1,PHF12,PDIA5,REXO2,MED6,CIRBP,IDH3B,RGS2,HINFP,STA
M2,NCBP2,PDGFRB,COL8A1,TGS1,NCAPD3,RAD51B,FAM76B,BDP1,
DBF4,CANX,RUNX1,MKNK2,SMARCA4,LMNB1,NAA16,LRPPRC,SUMF
1.39
139
389
3
8.
6
4
E
1
2
G
O:
00
44
23
8
primary metabolic process
2,SDAD1,SNX27,ZNF638,DCAF17,KLHL7,SNRPE,POLG,MRPL3,NCOR
2,FPGS,KANSL3,PDIA3,PRPF4B,COL13A1,FTSJ3,NARF,TROVE2,D2H
GDH,ATXN3,MAU2,PHF21A,PDCD4,LONP2,PSMA1,STAT6,CARS2,ACI
N1,SON,CLIC4,BTBD10,TFAM,PNISR,SPRED1,BRWD1,SMAD9,DUSP
6,ZBTB16,BAZ2A,SIRT3,KDELC2,RRP8,PHF19,SEPT2,LUC7L3,CES2,
SENP6,PDPK1,TSG101,USF1,FOXC1,KPNA1,ZC3H14,ACAN,STK24,F
MOD,PHC2,SMARCAD1,SYCP2L,ZC3H15,GATA2,PABPN1
FZD6,CDK14,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX
34,KANK2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,CKB,IGF1R,
GK5,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,RALGAPA2,MYNN,T
RNAU1AP,NOC2L,PPIL2,TARS,RAF1,ZNF131,SEPT5,GP1BB,RSC1A1,
DDI2,SFSWAP,CDK13,RBM6,TAZ,SIN3B,ATP2B1,SPOP,CPE,CBX5,PL
CD1,SART1,COL2A1,RAB34,SUPT5H,SUPT20H,ST3GAL1,MARCH5,U
BXN1,DPP4,PWP1,FBXO32,BCL6,FUBP1,ZNF783,CMPK2,TBX2,ENOS
F1,PTPN22,MMS19,GBP3,SPATA20,SHMT2,ZFP91,CNTF,EEF2K,PLD1
,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLNS1A,NUP98,EED,AMT,FM
R1,SMPD4,SMAD7,MCF2L,USP4,PPFIBP2,HDAC6,GLG1,ARHGEF12,E
biol HMT1,ATP6V1D,VRK2,RNH1,ZNF496,HGS,TYW1B,CASP4,DERL2,NA
ogic RS,LANCL2,H6PD,TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,SUPT4H1,Z
al_p NF83,PSMB9,EMX2,ARHGEF25,ADAMTS1,RGL4,RBPMS,XYLT1,STAR
roce D13,ZSCAN31,XBP1,CPM,FDPS,NISCH,PAM,ABCC1,NOM1,SNRNP70,
ss
HSD17B12,DDX23,RAD23A,METTL3,SCRN3,APITD1,MPDU1,MARK4,
UHMK1,USP47,ADAM8,NOL3,POLR3E,GABPB1,PRPF40A,DNAJC10,R
NF220,RAB35,PCGF6,RANBP1,SIPA1L1,MARCH6,DDX39A,KRIT1,SKI
V2L,MINK1,RHOF,PTPN6,SUGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF
3A,NOD1,PRKACA,STAT2,ANAPC4,RPP14,DHX9,PIGS,PLK1,ZNF446,
PDE7B,PREPL,ASNS,TBC1D2B,JAG2,DNM1L,PTGES2,UPF1,ZNF621,
HDGF,FDXR,RC3H1,PPP5C,PIGG,NPC1,CCNL1,HERC2,CHD6,ZC3H1
2A,NUP210,TBC1D10B,SEPT4,MIB2,POLM,SYMPK,EFTUD2,FAM58A,
ATG4B,CNP,CLN8,TBX18,PIGN,GCDH,LBX2,PCGF1,DR1,BCLAF1,CA
MK2D,ZNF721,ZNF397,JHDM1D,ZNF710,PLCB4,GIGYF2,DNPEP,TBC
1D14,GALK2,PRPF3,TNK2,USP20,GIT2,DCAF11,WAC,STK4,ZNF142,F
1.13
750
885
3
1.
6
4
E
1
0
UBP3,MTG1,RARS,ZNF540,ALDH18A1,COPS7B,MAN2C1,FGFR1,RAB
18,HSF4,C2,CFB,DISP1,PAIP1,CAPRIN1,GTF3C1,MMP16,ERH,NADSY
N1,PMS1,ADCY4,CELF1,PDE4D,RNASET2,SF3A2,TIMM23,PAF1,TAB2
,SGK1,PLEKHG4,SHARPIN,DPF2,CPT1B,CHKB,NADK,IDI1,RNF8,CYP
2R1,SEC31A,MDM2,RHBDD1,FKBP1A,ZFYVE26,PRKCH,ANAPC16,PP
M1F,ZNF595,TBP,DIS3L,IDH3G,YY1,FAM13A,INO80,GPAT2,GMEB2,S
SH2,MCFD2,PFDN5,TTC1,CREB1,NPTN,SRP9,RALGPS2,NAGK,FLII,P
LEKHG5,QSOX1,RPRD1A,DDX58,ALDH6A1,RPL27,CCNL2,PTPRK,SN
X13,RHBDF1,SERPINH1,NF1,ZEB1,ACAA1,NEK3,EIF4B,NUB1,IFITM3,
ASCC2,SPSB3,RGMB,RTKN,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL
,NPR1,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,ST3
GAL4,BRD9,CAPN10,DCAF8,GCNT2,ZNF837,PKD2,CASP2,HNRNPA3,
RXRB,GALT,UBE2Q1,MDP1,UBAC1,LMNA,RSL1D1,MITF,NOL8,USP24
,RB1,PRMT5,LTBP4,MAPK8IP3,RABGGTA,GNAI1,USP3,MZF1,ZFPM2,
TP53BP1,RNF168,MARK3,PAFAH1B1,ZNF865,SENP2,ISYNA1,EDEM2,
GPCPD1,IL18,PUM2,RNF217,STARD3,TPP1,SUB1,CHMP1A,PDE8A,N
SA2,AACS,STK38L,DDX6,ACAP2,ZNF558,GALNT2,ADAM15,SH3BP5,
MUM1,USP33,ZNF263,ZNF180,BICD1,NTMT1,ZNF276,RGS3,NR1H3,G
ARS,CYTH2,GRB10,MRPS7,PLK2,PAN2,HEXA,USP7,PLD6,FLCN,NRP
1,CUL4A,ZNF605,CHFR,ZNF410,PTGR2,FMO2,GMDS,RPL24,ARHGAP
9,UST,MTMR14,RPL37A,SAP30BP,MAST2,FAP,VPS72,PTEN,FYN,ALD
H1A3,IDH1,SRPK1,RNASEK,RUNX2,CSTF1,IQGAP1,C1R,FBXW7,PHP
T1,INTS4,PTP4A2,LGMN,SMARCD3,HERPUD1,IFT172,IKBKB,CTNS,R
QCD1,SNX17,PXN,ADAMTS18,KPNB1,SRGAP2,RFX7,PTPRF,NCOR1,
ATP11B,PPP1R10,MEF2A,OXCT1,PARN,FECH,PRKRIP1,SETD8,SME
K1,STK19,NECAB3,PIAS2,SSBP1,MAPK8,MYCBP2,MYLK,USP15,DDX
41,MAN1A2,SRRM2,PBX3,RNF213,N6AMT1,ZNF565,ABCA2,AFF4,TRI
M28,DENND4C,DMTF1,MAP4K4,CSK,CDK5RAP2,PTPRS,ITPA,PTPRC
,OAZ1,PSMC6,SWAP70,TBCD,IMPDH1,RNF146,UBP1,SKIV2L2,CDK6,
AGBL5,RARRES2,WDR61,EBF4,NUP37,PRPF8,DDHD2,FARSA,ZNF14
8
G
organic substance metabolic process
biol
FZD6,CDK14,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX
1.13
3.
O:
00
71
70
4
ogic
al_p
roce
ss
34,KANK2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,CKB,IGF1R,
GK5,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,RALGAPA2,MYNN,T
RNAU1AP,NOC2L,PPIL2,TARS,RAF1,ZNF131,SEPT5,GP1BB,SLC16A3
,RSC1A1,DDI2,SFSWAP,CDK13,RBM6,TAZ,SIN3B,ATP2B1,SPOP,CPE
,CBX5,PLCD1,SART1,COL2A1,RAB34,SUPT5H,SUPT20H,ST3GAL1,M
ARCH5,UBXN1,DPP4,PWP1,FBXO32,BCL6,FUBP1,ZNF783,CMPK2,TB
X2,ENOSF1,PTPN22,MMS19,GBP3,SPATA20,SHMT2,ZFP91,CNTF,EE
F2K,PLD1,VAPB,NLN,GPAA1,CUX1,PGS1,RBM17,CLNS1A,NUP98,EE
D,AMT,FMR1,SMPD4,SMAD7,MCF2L,USP4,PPFIBP2,HDAC6,GLG1,AR
HGEF12,EHMT1,ATP6V1D,VRK2,RNH1,ZNF496,HGS,TYW1B,CASP4,
DERL2,NARS,LANCL2,H6PD,TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,S
UPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,ADAMTS1,RGL4,RBPMS,X
YLT1,STARD13,ZSCAN31,XBP1,CPM,FDPS,NISCH,PAM,ABCC1,NOM
1,SNRNP70,HSD17B12,DDX23,RAD23A,METTL3,SCRN3,APITD1,MPD
U1,MARK4,UHMK1,USP47,ADAM8,NOL3,POLR3E,GABPB1,PRPF40A,
DNAJC10,RNF220,RAB35,PCGF6,RANBP1,SIPA1L1,MARCH6,DDX39A
,KRIT1,SKIV2L,MINK1,RHOF,PTPN6,SUGP1,EEF1A1,LHX4,CSNK2A1,I
GBP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC4,RPP14,DHX9,PIGS,PLK
1,ZNF446,PNPO,PDE7B,PREPL,ASNS,TBC1D2B,JAG2,DNM1L,TXNL1,
PTGES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1
,CCNL1,HERC2,CHD6,ZC3H12A,NUP210,TBC1D10B,SEPT4,MIB2,POL
M,SLC11A2,SYMPK,EFTUD2,FAM58A,ATG4B,CNP,CLN8,TBX18,PIGN,
GCDH,LBX2,PCGF1,DR1,BCLAF1,CAMK2D,ZNF721,ZNF397,JHDM1D,
SLC16A1,ZNF710,PLCB4,GIGYF2,DNPEP,TBC1D14,GALK2,PRPF3,TN
K2,USP20,GIT2,DCAF11,WAC,STK4,ZNF142,FUBP3,MTG1,RARS,ZNF
540,ALDH18A1,COPS7B,MAN2C1,FGFR1,HPS4,RAB18,HSF4,C2,CFB,
DISP1,PAIP1,CAPRIN1,GTF3C1,MMP16,ERH,NADSYN1,PMS1,ADCY4
,CELF1,SNCAIP,PDE4D,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,P
LEKHG4,SHARPIN,DPF2,CPT1B,CHKB,NADK,IDI1,RNF8,CYP2R1,SEC
31A,MDM2,RHBDD1,FKBP1A,ZFYVE26,PRKCH,ANAPC16,PPM1F,ZNF
595,TBP,DIS3L,IDH3G,YY1,FAM13A,INO80,GPAT2,GMEB2,SSH2,MCF
D2,PFDN5,TTC1,CREB1,NPTN,SRP9,RALGPS2,NAGK,FLII,PLEKHG5,
045
599
6
4
E
1
0
G
O:
00
43
23
2
intracellular non-membrane-bounded
organelle
QSOX1,RPRD1A,DDX58,ALDH6A1,RPL27,CCNL2,PTPRK,SNX13,RHB
DF1,SERPINH1,NF1,ZEB1,ACAA1,NEK3,EIF4B,CRIP1,SERBP1,NUB1,I
FITM3,ASCC2,SPSB3,RGMB,RTKN,EBF1,RPL9,MED28,PHF15,FKBP1
0,UNKL,NPR1,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,AL
G6,ST3GAL4,BRD9,CAPN10,DCAF8,GCNT2,ZNF837,PKD2,CASP2,HN
RNPA3,RXRB,GALT,UBE2Q1,MDP1,UBAC1,LMNA,RSL1D1,MITF,NOL
8,USP24,RB1,PRMT5,LTBP4,MAPK8IP3,RABGGTA,GNAI1,USP3,MZF1
,ZFPM2,TP53BP1,TXNDC5,RNF168,MARK3,PAFAH1B1,ZNF865,SENP
2,ISYNA1,EDEM2,GPCPD1,IL18,PUM2,RNF217,STARD3,TPP1,SUB1,C
HMP1A,PDE8A,NSA2,AACS,STK38L,DDX6,ACAP2,ZNF558,GALNT2,A
DAM15,SH3BP5,MUM1,USP33,ZNF263,ZNF180,BICD1,NTMT1,LYSMD
4,ZNF276,RGS3,NR1H3,GARS,CYTH2,GRB10,MRPS7,PLK2,PAN2,HE
XA,USP7,PLD6,FLCN,NRP1,CUL4A,ZNF605,CHFR,ZNF410,PTGR2,TE
NC1,FMO2,GMDS,RPL24,ARHGAP9,UST,MTMR14,RPL37A,SAP30BP,
MAST2,FAP,VPS72,PTEN,FYN,ALDH1A3,IDH1,SRPK1,RNASEK,RUNX
2,CSTF1,IQGAP1,C1R,FBXW7,PHPT1,INTS4,PTP4A2,LGMN,SMARCD
3,HERPUD1,IFT172,IKBKB,CTNS,RQCD1,SNX17,PXN,ADAMTS18,KP
NB1,SRGAP2,RFX7,PTPRF,NCOR1,ATP11B,PPP1R10,MEF2A,OXCT1,
PARN,FECH,PRKRIP1,SETD8,SMEK1,STK19,NECAB3,PIAS2,SSBP1,
MAPK8,MYCBP2,UPK3B,MYLK,USP15,DDX41,MAN1A2,SRRM2,PBX3,
RNF213,N6AMT1,ZNF565,ABCA2,AFF4,TRIM28,DENND4C,DMTF1,MA
P4K4,CSK,CDK5RAP2,PTPRS,ITPA,PTPRC,OAZ1,PSMC6,SWAP70,TB
CD
MARVELD1,USP10,RNASEH2B,CRBN,OBFC1,ACADVL,XRN1,TNRC6
A,MYO1D,SIRT2,EPHX2,UTRN,RAI14,NOC2L,PPIL2,TARS,SEPT5,SLC
cell 16A3,PPP1R13B,GAS8,RSC1A1,SIN3B,CBX5,SART1,CCDC91,RAB34,
ular SUPT5H,RILPL1,BCL6,FUBP1,CMPK2,MMS19,SHMT2,ZFP91,CUX1,R
_co BM17,CLNS1A,NUP98,EED,FMR1,HDAC6,EHMT1,DYNC1I1,LANCL2,S
mpo YTL4,TTLL3,ARPC4nent TTLL3,PNKP,PAX8,ARHGEF25,BCL2L11,STARD9,CPM,FDPS,ABCC1,
NOM1,CEP135,DDX23,APITD1,MARK4,UHMK1,ADAM8,MAP7D1,NOL3
,POLR3E,CAPZB,PRPF40A,RANBP1,SIPA1L1,KRIT1,MINK1,PDLIM5,R
1.31
505
312
9
1.
1
8
E
0
9
HOF,SUGP1,ACTR3,VASP,CSNK2A1,UPF3A,PRKACA,DHX9,PLK1,SD
CCAG8,NUTF2,TTC19,DNM1L,UPF1,RC3H1,PDXK,HERC2,ZC3H12A,S
EPT4,SYMPK,EFTUD2,CNP,PCGF1,BCLAF1,JHDM1D,PLCB4,PRPF3,F
LG,MTG1,CCDC14,RARS,CAPRIN1,GTF3C1,SNCAIP,PDE4D,AFAP1,P
AF1,SHARPIN,DPF2,TCHP,RNF8,KIAA0586,MDM2,SNAP23,ZFYVE26,
DAZAP1,TBP,DIS3L,IDH3G,YY1,TLN2,INO80,GMEB2,SSH2,CREB1,TR
AF3IP1,FLII,DDX58,ALDH6A1,RPL27,ZEB1,NUMA1,TPM4,RPL9,MED2
8,ZNF3,RPS6KA5,G3BP1,PKD2,HNRNPA3,LMNA,RSL1D1,NOL8,PPP2
R3C,RB1,GNAI1,USP3,STX16,TP53BP1,NEXN,RNF168,PAFAH1B1,RP
S19BP1,PUM2,CALCOCO2,DNALI1,SUB1,PWP2,CHMP1A,NSA2,ARPC
2,SYNE1,STK38L,DDX6,ZNF263,BICD1,NTMT1,NR1H3,MRPS7,PLK2,P
AN2,NRP1,RPL24,DAAM1,RPL37A,SAP30BP,MAST2,FYN,RUNX2,IQG
AP1,FBXW7,CEP112,SMARCD3,RQCD1,PXN,SRGAP2,NCOR1,PPP1R
10,MEF2A,PARN,TNS1,PRKRIP1,SETD8,SMEK1,TCTN1,SSBP1,VILL,
MYCBP2,CLTCL1,MYLK,DDX41,MAN1A2,SRRM2,ABCA2,RAB8A,AFF4
,TRIM28,DMTF1,CSK,CDK5RAP2,PSMC6,RPF2,TBCD,SKIV2L2,DSN1,
NSFL1C,WDR61,NUP37,DDHD2,ZNF148,FLOT1,WDR13,PSMC4,KIFC
2,STAG2,SP110,GOPC,RANBP9,WDR35,PAK1,EVC,HNRNPH3,ACD,H
MGN2,ATP6V0A1,DGKZ,ACTR2,PIWIL4,SS18,SMAD4,FNTB,KLC1,NA
V1,TGFB1I1,INO80E,EZR,RPL4,MTRR,CENPT,ZNF44,AUP1,ZNF687,C
DC14B,CLK3,DNHD1,NR2C2,FHOD1,FIP1L1,DNTTIP2,MRPL49,FLNA,
RAB5A,SUN2,MSL1,ACTR10,GLI3,ADD3,AK5,ENG,SIRT7,GAPDH,ERC
C1,PHF1,PRELID1,PHF12,TBCE,REXO2,CIRBP,NUP85,CTTN,HAUS5,
RGS2,CLIP2,HINFP,STAM2,NCBP2,PTPN4,DZIP1,NCAPD3,CC2D2A,M
YO7B,FARP1,CANX,RUNX1,SMARCA4,LMNB1,LRPPRC,YIF1A,RPLP0
,SDAD1,SNX27,KIF13B,PTPN23,ZNF638,TLN1,DCAF17,KLHL7,PHC3,
DNAJC21,POLG,MRPL3,NCOR2,TTLL11,SETD2,TWF1,PRPF4B,FTSJ3
,NARF,TROVE2,MYO1E,CORO7,DYNC1I2,MAU2,NUCB1,GPHN,PDCD
4,PSMA1,STAT6,TANC1,ACIN1,PSD3,SON,CLIC4,NSMCE4A,BNIP2,BT
BD10,TFAM,SHPRH,SPRED1,BRWD1,BAZ2A,RRP8,SEPT2,LUC7L3,S
ENP6,TSG101,THAP6,FOXC1,ZC3H14,SSH1,C2CD3,PABPC1,PHC2,S
MARCAD1,CLASP1,CC2D1A,SYCP2L,ZC3H15,GATA2,PABPN1
G
O:
00
43
22
8
non-membrane-bounded organelle
MARVELD1,USP10,RNASEH2B,CRBN,OBFC1,ACADVL,XRN1,TNRC6
A,MYO1D,SIRT2,EPHX2,UTRN,RAI14,NOC2L,PPIL2,TARS,SEPT5,SLC
16A3,PPP1R13B,GAS8,RSC1A1,SIN3B,CBX5,SART1,CCDC91,RAB34,
SUPT5H,RILPL1,BCL6,FUBP1,CMPK2,MMS19,SHMT2,ZFP91,CUX1,R
BM17,CLNS1A,NUP98,EED,FMR1,HDAC6,EHMT1,DYNC1I1,LANCL2,S
YTL4,TTLL3,ARPC4TTLL3,PNKP,PAX8,ARHGEF25,BCL2L11,STARD9,CPM,FDPS,ABCC1,
NOM1,CEP135,DDX23,APITD1,MARK4,UHMK1,ADAM8,MAP7D1,NOL3
,POLR3E,CAPZB,PRPF40A,RANBP1,SIPA1L1,KRIT1,MINK1,PDLIM5,R
HOF,SUGP1,ACTR3,VASP,CSNK2A1,UPF3A,PRKACA,DHX9,PLK1,SD
CCAG8,NUTF2,TTC19,DNM1L,UPF1,RC3H1,PDXK,HERC2,ZC3H12A,S
EPT4,SYMPK,EFTUD2,CNP,PCGF1,BCLAF1,JHDM1D,PLCB4,PRPF3,F
LG,MTG1,CCDC14,RARS,CAPRIN1,GTF3C1,SNCAIP,PDE4D,AFAP1,P
AF1,SHARPIN,DPF2,TCHP,RNF8,KIAA0586,MDM2,SNAP23,ZFYVE26,
cell
DAZAP1,TBP,DIS3L,IDH3G,YY1,TLN2,INO80,GMEB2,SSH2,CREB1,TR
ular
AF3IP1,FLII,DDX58,ALDH6A1,RPL27,ZEB1,NUMA1,TPM4,RPL9,MED2
_co
8,ZNF3,RPS6KA5,G3BP1,PKD2,HNRNPA3,LMNA,RSL1D1,NOL8,PPP2
mpo
R3C,RB1,GNAI1,USP3,STX16,TP53BP1,NEXN,RNF168,PAFAH1B1,RP
nent
S19BP1,PUM2,CALCOCO2,DNALI1,SUB1,PWP2,CHMP1A,NSA2,ARPC
2,SYNE1,STK38L,DDX6,ZNF263,BICD1,NTMT1,NR1H3,MRPS7,PLK2,P
AN2,NRP1,RPL24,DAAM1,RPL37A,SAP30BP,MAST2,FYN,RUNX2,IQG
AP1,FBXW7,CEP112,SMARCD3,RQCD1,PXN,SRGAP2,NCOR1,PPP1R
10,MEF2A,PARN,TNS1,PRKRIP1,SETD8,SMEK1,TCTN1,SSBP1,VILL,
MYCBP2,CLTCL1,MYLK,DDX41,MAN1A2,SRRM2,ABCA2,RAB8A,AFF4
,TRIM28,DMTF1,CSK,CDK5RAP2,PSMC6,RPF2,TBCD,SKIV2L2,DSN1,
NSFL1C,WDR61,NUP37,DDHD2,ZNF148,FLOT1,WDR13,PSMC4,KIFC
2,STAG2,SP110,GOPC,RANBP9,WDR35,PAK1,EVC,HNRNPH3,ACD,H
MGN2,ATP6V0A1,DGKZ,ACTR2,PIWIL4,SS18,SMAD4,FNTB,KLC1,NA
V1,TGFB1I1,INO80E,EZR,RPL4,MTRR,CENPT,ZNF44,AUP1,ZNF687,C
DC14B,CLK3,DNHD1,NR2C2,FHOD1,FIP1L1,DNTTIP2,MRPL49,FLNA,
RAB5A,SUN2,MSL1,ACTR10,GLI3,ADD3,AK5,ENG,SIRT7,GAPDH,ERC
C1,PHF1,PRELID1,PHF12,TBCE,REXO2,CIRBP,NUP85,CTTN,HAUS5,
1.31
505
312
9
1.
1
8
E
0
9
G
O:
00
08
15
2
metabolic process
RGS2,CLIP2,HINFP,STAM2,NCBP2,PTPN4,DZIP1,NCAPD3,CC2D2A,M
YO7B,FARP1,CANX,RUNX1,SMARCA4,LMNB1,LRPPRC,YIF1A,RPLP0
,SDAD1,SNX27,KIF13B,PTPN23,ZNF638,TLN1,DCAF17,KLHL7,PHC3,
DNAJC21,POLG,MRPL3,NCOR2,TTLL11,SETD2,TWF1,PRPF4B,FTSJ3
,NARF,TROVE2,MYO1E,CORO7,DYNC1I2,MAU2,NUCB1,GPHN,PDCD
4,PSMA1,STAT6,TANC1,ACIN1,PSD3,SON,CLIC4,NSMCE4A,BNIP2,BT
BD10,TFAM,SHPRH,SPRED1,BRWD1,BAZ2A,RRP8,SEPT2,LUC7L3,S
ENP6,TSG101,THAP6,FOXC1,ZC3H14,SSH1,C2CD3,PABPC1,PHC2,S
MARCAD1,CLASP1,CC2D1A,SYCP2L,ZC3H15,GATA2,PABPN1
FZD6,CDK14,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX
34,KANK2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,CKB,IGF1R,
GK5,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,RALGAPA2,MYNN,T
RNAU1AP,NOC2L,PPIL2,TARS,RAF1,NLRP1,ZNF131,SEPT5,GP1BB,L
EPRE1,SLC16A3,RSC1A1,DDI2,SFSWAP,CDK13,RBM6,BDNF,TAZ,SI
N3B,ATP2B1,SPOP,CPE,CBX5,PLCD1,SART1,COL2A1,RAB34,SUPT5
H,SUPT20H,ERCC6L2,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO3
2,BCL6,FUBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,GBP3,
SPATA20,SHMT2,ZFP91,CNTF,EEF2K,PLD1,VAPB,NLN,GPAA1,CUX1,
biol PGS1,PARP6,RBM17,CLNS1A,NUP98,EED,SLC9B2,AMT,FMR1,SMPD
ogic 4,SMAD7,MCF2L,USP4,PPFIBP2,HDAC6,GLG1,ARHGEF12,EHMT1,AT
al_p P6V1D,VRK2,DYNC1I1,RNH1,ZNF496,HGS,TYW1B,CASP4,DERL2,NA
roce RS,LANCL2,H6PD,DGKA,TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,SUPT
ss
4H1,ZNF83,PSMB9,EMX2,ARHGEF25,ADAMTS1,RGL4,BCL2L13,BCL2
L11,RBPMS,XYLT1,STARD13,ZSCAN31,STARD9,XBP1,CPM,FDPS,NI
SCH,PAM,ABCC1,NOM1,GLT8D1,SNRNP70,HSD17B12,DDX23,RAD23
A,METTL3,SCRN3,APITD1,MPDU1,MARK4,UHMK1,USP47,ADAM8,NO
L3,POLR3E,GABPB1,PRPF40A,DNAJC10,RNF220,RAB35,PCGF6,RAN
BP1,SIPA1L1,MARCH6,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,PTPN6,S
UGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,
ANAPC4,RPP14,DHX9,PIGS,PLK1,ZNF446,PNPO,PDE7B,PREPL,ASN
S,TBC1D2B,ECHDC1,JAG2,DNM1L,TXNL1,PTGES2,UPF1,ZNF621,HD
GF,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1,CCNL1,HERC2,CHD6,ZC3
1.10
627
529
7
1.
8
3
E
0
9
H12A,NUP210,TBC1D10B,SEPT4,MIB2,POLM,SLC11A2,DIP2A,SYMPK
,EFTUD2,FAM58A,RAB24,ATG4B,CNP,CLN8,TBX18,PIGN,GCDH,LBX2
,PCGF1,DR1,BCLAF1,CAMK2D,ZNF721,ZNF397,JHDM1D,SLC16A1,ZN
F710,PLCB4,GIGYF2,DHRSX,DNPEP,TBC1D14,GALK2,PRPF3,TNK2,E
NGASE,USP20,GIT2,DCAF11,WAC,STK4,ZNF142,FUBP3,MTG1,RARS
,ZNF540,ALDH18A1,COPS7B,MAN2C1,FGFR1,HPS4,RAB18,HSF4,C2,
CFB,DISP1,PAIP1,CAPRIN1,GTF3C1,MMP16,ERH,NADSYN1,PMS1,A
DCY4,CELF1,SNCAIP,PDE4D,RNASET2,SF3A2,TIMM23,PAF1,TAB2,S
GK1,PLEKHG4,SHARPIN,DPF2,CPT1B,CHKB,NADK,IDI1,RNF8,CDYL2
,CYP2R1,SEC31A,MDM2,KCMF1,RHBDD1,FKBP1A,ZFYVE26,PRKCH,
MTMR11,ANAPC16,PPM1F,ZNF595,TBP,DIS3L,IDH3G,YY1,FAM13A,IN
O80,GPAT2,GMEB2,SSH2,MCFD2,PFDN5,TTC1,CREB1,NPTN,SRP9,R
ALGPS2,NAGK,FLII,PLEKHG5,QSOX1,RPRD1A,DDX58,ALDH6A1,RPL
27,ZCCHC9,CCNL2,PTPRK,SNX13,RHBDF1,SERPINH1,NF1,ZEB1,AC
AA1,NEK3,EIF4B,CRIP1,SERBP1,NUB1,IFITM3,ASCC2,ATG12,SPSB3,
RGMB,RTKN,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,NPR1,ZNF3,R
PS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,BRD9,C
APN10,DCAF8,GCNT2,NTPCR,ZNF837,PKD2,CASP2,HNRNPA3,RXRB
,GALT,UBE2Q1,NEDD8MDP1,MDP1,UBAC1,LMNA,NUDT6,RSL1D1,MITF,NOL8,USP24,RB1,P
RMT5,HMGXB3,LTBP4,MAPK8IP3,RABGGTA,GNAI1,USP3,DHRS1,MZ
F1,ZFPM2,CPPED1,TP53BP1,TXNDC5,RNF168,MARK3,PAFAH1B1,ZN
F865,SENP2,ISYNA1,EDEM2,GPCPD1,IL18,PUM2,MTCH1,RNF217,ST
ARD3,TPP1,SYTL2,DNALI1,SUB1,CHMP1A,PDE8A,NSA2,AACS,STK38
L,DDX6,ACAP2,ZNF558,ANXA5,GALNT2,ADAM15,SH3BP5,MUM1,USP
33,ZNF263,ZNF180,BICD1,NTMT1,LYSMD4,ZNF276,RGS3,NR1H3,GA
RS,CYTH2,GRB10,MRPS7,PLK2,PAN2,HEXA,USP7,PLD6,FLCN,NRP1,
CUL4A,ZNF605,CHFR,ZNF410,PTGR2,TENC1,FMO2,GMDS,RPL24,AR
HGAP9,UST,MTMR14,RPL37A,SAP30BP,MAST2,FAP,VPS72,PTEN,FY
N,ALDH1A3,IDH1,SRPK1,RNASEK,RUNX2,CSTF1,IQGAP1,C1R,FBXW
7,PHPT1,INTS4,PTP4A2,LGMN,SMARCD3,HERPUD1,IFT172,IKBKB,C
TNS,RQCD1,SNX17,PXN,ADAMTS18,KPNB1,SRGAP2,RFX7,PTPRF,N
G
O:
00
43
17
0
macromolecule metabolic process
COR1,ATP11B,PPP1R10,MEF2A,OXCT1,PARN,FECH,PRKRIP1,SETD
8
FZD6,CDK14,USP10,RNASEH2B,CRBN,OBFC1,PBX2,KANK2,ACADVL
,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,IGF1R,TNRC6A,SIRT2,EPHX2,M
YNN,TRNAU1AP,NOC2L,PPIL2,TARS,RAF1,ZNF131,GP1BB,RSC1A1,
DDI2,SFSWAP,CDK13,RBM6,SIN3B,SPOP,CPE,CBX5,SART1,COL2A1,
SUPT5H,SUPT20H,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,B
CL6,FUBP1,ZNF783,TBX2,PTPN22,MMS19,ZFP91,CNTF,EEF2K,VAPB,
NLN,GPAA1,CUX1,RBM17,CLNS1A,NUP98,EED,FMR1,SMAD7,MCF2L
,USP4,PPFIBP2,HDAC6,GLG1,EHMT1,VRK2,RNH1,ZNF496,HGS,TYW
1B,CASP4,DERL2,NARS,LANCL2,TTLL3,PRMT10,PNKP,LEF1,PAX8,S
UPT4H1,ZNF83,PSMB9,EMX2,ADAMTS1,RBPMS,XYLT1,ZSCAN31,XB
P1,CPM,PAM,NOM1,SNRNP70,DDX23,RAD23A,METTL3,SCRN3,APIT
D1,MPDU1,MARK4,UHMK1,USP47,ADAM8,NOL3,POLR3E,GABPB1,P
RPF40A,DNAJC10,RNF220,PCGF6,MARCH6,DDX39A,MINK1,PTPN6,S
biol
UGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,
ogic
ANAPC4,RPP14,DHX9,PIGS,PLK1,ZNF446,PREPL,ASNS,JAG2,PTGES
al_p
2,UPF1,ZNF621,HDGF,RC3H1,PPP5C,PIGG,NPC1,CCNL1,HERC2,CH
roce
D6,ZC3H12A,SEPT4,MIB2,POLM,SYMPK,EFTUD2,FAM58A,ATG4B,CN
ss
P,CLN8,TBX18,PIGN,LBX2,PCGF1,DR1,BCLAF1,CAMK2D,ZNF721,ZN
F397,JHDM1D,ZNF710,GIGYF2,DNPEP,PRPF3,TNK2,USP20,DCAF11,
WAC,STK4,ZNF142,FUBP3,RARS,ZNF540,COPS7B,FGFR1,HPS4,HSF
4,C2,CFB,DISP1,PAIP1,CAPRIN1,GTF3C1,MMP16,PMS1,ADCY4,CELF
1,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,SHARPIN,DPF2,RNF8,S
EC31A,MDM2,RHBDD1,FKBP1A,ZFYVE26,PRKCH,ANAPC16,PPM1F,Z
NF595,TBP,DIS3L,YY1,INO80,GMEB2,SSH2,MCFD2,PFDN5,TTC1,CR
EB1,NPTN,SRP9,FLII,QSOX1,RPRD1A,DDX58,RPL27,CCNL2,PTPRK,
RHBDF1,SERPINH1,NF1,ZEB1,NEK3,EIF4B,CRIP1,SERBP1,NUB1,IFIT
M3,ASCC2,SPSB3,RGMB,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,N
PR1,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ALG6,ST3GAL4,B
RD9,CAPN10,DCAF8,GCNT2,ZNF837,PKD2,CASP2,HNRNPA3,RXRB,
UBE2Q1,MDP1,UBAC1,LMNA,RSL1D1,MITF,NOL8,USP24,RB1,PRMT5
1.16
573
433
6
2.
5
4
E
0
9
G
O:
00
44
26
0
cellular macromolecule metabolic process
,LTBP4,MAPK8IP3,RABGGTA,USP3,MZF1,ZFPM2,TP53BP1,RNF168,M
ARK3,ZNF865,SENP2,EDEM2,IL18,PUM2,RNF217,TPP1,SUB1,CHMP1
A,PDE8A,NSA2,STK38L,DDX6,ZNF558,GALNT2,ADAM15,SH3BP5,MU
M1,USP33,ZNF263,ZNF180,BICD1,NTMT1,LYSMD4,ZNF276,RGS3,NR
1H3,GARS,GRB10,MRPS7,PLK2,PAN2,HEXA,USP7,PLD6,FLCN,NRP1,
CUL4A,ZNF605,CHFR,ZNF410,TENC1,RPL24,UST,MTMR14,RPL37A,S
AP30BP,MAST2,FAP,VPS72,PTEN,FYN,SRPK1,RNASEK,RUNX2,CST
F1,IQGAP1,C1R,FBXW7,PHPT1,INTS4,PTP4A2,LGMN,SMARCD3,HER
PUD1,IFT172,IKBKB,RQCD1,PXN,ADAMTS18,KPNB1,RFX7,PTPRF,NC
OR1,PPP1R10,MEF2A,PARN,FECH,PRKRIP1,SETD8,SMEK1,STK19,N
ECAB3,PIAS2,SSBP1,MAPK8,MYCBP2,UPK3B,MYLK,USP15,DDX41,M
AN1A2,SRRM2,PBX3,RNF213,N6AMT1,ZNF565,ABCA2,AFF4,TRIM28,
DMTF1,MAP4K4,CSK,CDK5RAP2,PTPRS,PTPRC,OAZ1,PSMC6,SWAP
70,TBCD,RNF146,UBP1,SKIV2L2,CDK6,AGBL5,WDR61,EBF4,PRPF8,F
ARSA,ZNF148,ZNF76,PSMC4,HNRNPL,SGSM3,STAG2,UBA2,AAK1,S
P110,PPA2,ST6GALNAC5,PHKG2,PAK1,NCK2,HNRNPH3,CTSH,ZSWI
M7,TCF4,ACD,TRPM7,IKZF5,HMGN2,WDR4,SEMA4D,SSBP2,CSF1R,
ERC1,TIMM50,OS9,C3,NFYC,P4HB,FUT4,PIWIL4,RPUSD4,SRSF10,SS
18,RCOR3,SMAD4,GRPEL2,FNTB,CHURC1,CHURC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,INO80E,ASB8,RPL4,ZNF44,
CREBZF,ING4,USP54,CD276,RBMS1,CDCA3,EIF3M,ZNF687,CDC14B,
CLK3,NR2C2,FHOD1,FIP1L1,DNTTIP2,LRPAP1,APOL3,MRPL49,FLNA,
RAB5A,IRF9,MSL1,HGSNAT,MGAT5,C1S,GLI3,TMED2,MAPK12,CCDC
59,DCAF6,AK5,GUSB,THOC2,B4GALT4,ENG,SIRT7,ZSCAN5A,TCF12,
PCSK7,ARNT,NOX4,ZNF692,EXT1,GAPDH,ERCC1
FZD6,CDK14,USP10,RNASEH2B,CRBN,OBFC1,PBX2,KANK2,ACADVL
biol ,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,IGF1R,TNRC6A,SIRT2,MYNN,T
ogic RNAU1AP,NOC2L,PPIL2,TARS,RAF1,ZNF131,RSC1A1,SFSWAP,CDK1
al_p 3,RBM6,SIN3B,SPOP,CPE,CBX5,SART1,COL2A1,SUPT5H,SUPT20H,S
roce T3GAL1,MARCH5,UBXN1,PWP1,FBXO32,BCL6,FUBP1,ZNF783,TBX2,
ss
PTPN22,MMS19,ZFP91,CNTF,EEF2K,VAPB,GPAA1,CUX1,RBM17,CLN
S1A,NUP98,EED,FMR1,SMAD7,MCF2L,USP4,PPFIBP2,HDAC6,EHMT1
1.18
036
433
2
4.
5
4
E
0
9
,VRK2,RNH1,ZNF496,TYW1B,DERL2,NARS,LANCL2,TTLL3,PRMT10,P
NKP,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,RBPMS,XYLT1,ZSCA
N31,XBP1,PAM,NOM1,SNRNP70,DDX23,RAD23A,METTL3,APITD1,MP
DU1,MARK4,UHMK1,USP47,ADAM8,NOL3,POLR3E,GABPB1,PRPF40
A,DNAJC10,RNF220,PCGF6,MARCH6,DDX39A,MINK1,PTPN6,SUGP1,
EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC
4,RPP14,DHX9,PIGS,PLK1,ZNF446,ASNS,JAG2,PTGES2,UPF1,ZNF62
1,HDGF,RC3H1,PPP5C,PIGG,NPC1,CCNL1,HERC2,CHD6,ZC3H12A,S
EPT4,MIB2,POLM,SYMPK,EFTUD2,FAM58A,CNP,CLN8,TBX18,PIGN,L
BX2,PCGF1,DR1,BCLAF1,CAMK2D,ZNF721,ZNF397,JHDM1D,ZNF710,
GIGYF2,PRPF3,TNK2,USP20,DCAF11,WAC,STK4,ZNF142,FUBP3,RA
RS,ZNF540,COPS7B,FGFR1,HSF4,PAIP1,CAPRIN1,GTF3C1,PMS1,AD
CY4,CELF1,RNASET2,SF3A2,TIMM23,PAF1,TAB2,SGK1,SHARPIN,DP
F2,RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,ZFYVE26,PRKCH,ANAPC1
6,PPM1F,ZNF595,TBP,DIS3L,YY1,INO80,GMEB2,SSH2,MCFD2,PFDN5
,TTC1,CREB1,NPTN,SRP9,FLII,QSOX1,RPRD1A,DDX58,RPL27,CCNL
2,PTPRK,RHBDF1,NF1,ZEB1,NEK3,EIF4B,NUB1,IFITM3,ASCC2,SPSB
3,RGMB,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,NPR1,ZNF3,RPS6K
A5,G3BP1,NIPBL,RAB31,ALKBH3,ALG6,ST3GAL4,BRD9,DCAF8,GCNT
2,ZNF837,PKD2,HNRNPA3,RXRB,UBE2Q1,MDP1,UBAC1,LMNA,RSL1
D1,MITF,NOL8,USP24,RB1,PRMT5,LTBP4,MAPK8IP3,RABGGTA,USP3
,MZF1,ZFPM2,TP53BP1,RNF168,MARK3,ZNF865,SENP2,EDEM2,PUM
2,RNF217,TPP1,SUB1,CHMP1A,PDE8A,NSA2,STK38L,DDX6,ZNF558,
GALNT2,SH3BP5,MUM1,USP33,ZNF263,ZNF180,BICD1,NTMT1,LYSM
D4,ZNF276,RGS3,NR1H3,GARS,GRB10,MRPS7,PLK2,PAN2,HEXA,US
P7,PLD6,FLCN,NRP1,CUL4A,ZNF605,CHFR,ZNF410,RPL24,UST,MTM
R14,RPL37A,SAP30BP,MAST2,VPS72,PTEN,FYN,SRPK1,RNASEK,RU
NX2,CSTF1,IQGAP1,FBXW7,PHPT1,INTS4,PTP4A2,SMARCD3,HERPU
D1,IKBKB,RQCD1,PXN,KPNB1,RFX7,PTPRF,NCOR1,PPP1R10,MEF2A
,PARN,FECH,PRKRIP1,SETD8,SMEK1,STK19,NECAB3,PIAS2,SSBP1,
MAPK8,MYCBP2,MYLK,USP15,DDX41,MAN1A2,SRRM2,PBX3,RNF213
,N6AMT1,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,MAP4K4,CSK,CDK5R
G
O:
00
44
42
8
nuclear part
AP2,PTPRS,PTPRC,PSMC6,SWAP70,TBCD,RNF146,UBP1,SKIV2L2,C
DK6,AGBL5,WDR61,EBF4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNR
NPL,STAG2,UBA2,AAK1,SP110,PPA2,ST6GALNAC5,PHKG2,PAK1,NC
K2,HNRNPH3,ZSWIM7,TCF4,ACD,TRPM7,IKZF5,HMGN2,WDR4,SEMA
4D,SSBP2,CSF1R,ERC1,TIMM50,OS9,C3,NFYC,P4HB,FUT4,PIWIL4,R
PUSD4,SRSF10,SS18,RCOR3,SMAD4,GRPEL2,FNTB,CHURC1,CHUR
C1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,ASB8,RPL4,ZNF44,CREBZF,IN
G4,USP54,RBMS1,CDCA3,EIF3M,ZNF687,CDC14B,CLK3,NR2C2,FHO
D1,FIP1L1,DNTTIP2,LRPAP1,MRPL49,FLNA,RAB5A,IRF9,MSL1,MGAT
5,GLI3,MAPK12,CCDC59,DCAF6,AK5,THOC2,B4GALT4,ENG,SIRT7,ZS
CAN5A,TCF12,ARNT,NOX4,ZNF692,EXT1,GAPDH,ERCC1,PHF1,GAA,
MTRF1L,NRBP2,B3GAT3,SLC25A6,STK36,WWP1,PHF12,PDIA5,TBCE,
MED6,MDFI,CIRBP,UBA6,RABGGTB,ZNF554,NAA10,CIZ1,PTPRD,ITG
A5,RGS2,HINFP,NCBP2,MAN2A2,MLX,PDGFRB,PTPN4,TGS1,NCAPD
3,RAD51B,CDK11A,MAN1B1,GLIS3,ELP6,CARD14,BDP1,TNFRSF14,D
BF4,CANX,RUNX1,MKNK2,TRIM41,SMARCA4
RNASEH2B,CRBN,OBFC1,PBX2,GTF3C2,PSMB10,SIRT2,EPHX2,UTR
N,NOC2L,PPIL2,SLC16A3,PPP1R13B,RSC1A1,CDK13,SIN3B,CBX5,SA
RT1,CCDC91,RAB34,SUPT5H,SUPT20H,RILPL1,BCL6,FUBP1,CMPK2,
TBX2,MMS19,ZFP91,CUX1,RBM17,NUP98,EED,FMR1,SMAD7,HDAC6,
ZNF496,IL15RA,SYTL4,PNKP,LEF1,PAX8,SUPT4H1,PSMB9,XBP1,CP
cell M,FDPS,ABCC1,NOM1,SNRNP70,DDX23,METTL3,APITD1,NOL3,POL
ular R3E,PRPF40A,PCGF6,RANBP1,SUGP1,CSNK2A1,UPF3A,STAT2,ANA
_co PC4,DHX9,PLK1,NUTF2,UPF1,HDGF,PDXK,NPC1,SHISA5,CCNL1,ZC3
mpo H12A,NUP210,SEPT4,SYMPK,EFTUD2,PCGF1,DR1,BCLAF1,CAMK2D,
nent FYTTD1,JHDM1D,PRPF3,GIT2,WAC,MTG1,RARS,COPS7B,GTF3C1,P
MS1,SNCAIP,SF3A2,PAF1,DPF2,MDM2,SNAP23,DAZAP1,ANAPC16,T
BP,IDH3G,YY1,INO80,GMEB2,CREB1,FLII,RPRD1A,ALDH6A1,CCNL2,
ZEB1,NUMA1,RPL9,MED28,PHF15,ZNF3,RPS6KA5,NIPBL,ALKBH3,HN
RNPA3,RXRB,LMNA,RSL1D1,NOL8,RB1,USP3,STX16,ZFPM2,TP53BP
1,PAFAH1B1,SENP2,RPS19BP1,CALCOCO2,SUB1,PWP2,CHMP1A,N
1.34
995
522
1
5.
0
2
E
0
9
G
O:
00
44
23
7
cellular metabolic process
SA2,SYNE1,STK38L,ZNF263,NTMT1,NR1H3,USP7,CHFR,SAP30BP,PT
EN,SRPK1,RUNX2,CSTF1,IQGAP1,FBXW7,INTS4,SMARCD3,KPNB1,N
COR1,ATP11B,MEF2A,PARN,PRKRIP1,PIAS2,MAPK8,DDX41,MAN1A2
,SRRM2,OSBPL3,PBX3,AFF4,TRIM28,DMTF1,PSMC6,RPF2,SKIV2L2,
WDR61,NUP37,PRPF8,APPL2,ZNF148,FLOT1,WDR13,PSMC4,HNRNP
L,STAG2,SP110,ATPAF2,PAK1,RHEB,HNRNPH3,TCF4,ACD,WDR4,AT
P6V0A1,TIMM50,DGKZ,NFYC,SRSF10,SMAD4,TGFB1I1,INO80E,EZR,
RPL4,MTRR,ZNF44,AUP1,GOLPH3,ING4,ZNF687,CDC14B,CLK3,NR2
C2,FIP1L1,DNTTIP2,IRF9,SUN2,MSL1,ATP5A1,GLI3,ADD3,MAPK12,T
HOC2,ENG,SIRT7,TCF12,ARNT,ERCC1,PHF1,PRELID1,PHF12,REXO2
,MED6,CIRBP,NUP85,RGS2,HINFP,STAM2,NCBP2,TGS1,NCAPD3,RA
D51B,GLIS3,FAM76B,BDP1,DBF4,RUNX1,MKNK2,SMARCA4,LMNB1,N
AA16,LRPPRC,SDAD1,SNX27,ZNF638,DCAF17,KLHL7,PHC3,SNRPE,
NCOR2,KANSL3,PRPF4B,FTSJ3,NARF,WDFY3,TROVE2,ATXN3,MAU2
,PHF21A,PDCD4,PSMA1,STAT6,ACIN1,SON,CLIC4,BNIP2,BTBD10,PN
ISR,SPRED1,BRWD1,SMAD9,DUSP6,ZBTB16,BAZ2A,RRP8,PHF19,SE
PT2,LUC7L3,SENP6,PDPK1,TSG101,USF1,FOXC1,KPNA1,ZC3H14,ST
K24,PABPC1,PHC2,SMARCAD1,SYCP2L,ZC3H15,GATA2,PABPN1
FZD6,CDK14,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX
34,KANK2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,CKB,IGF1R,
GK5,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,RALGAPA2,MYNN,TRNAU1
AP,NOC2L,PPIL2,TARS,RAF1,ZNF131,SEPT5,SLC16A3,RSC1A1,SFS
WAP,CDK13,RBM6,BDNF,TAZ,SIN3B,ATP2B1,SPOP,CPE,CBX5,PLCD
biol
1,SART1,COL2A1,RAB34,SUPT5H,SUPT20H,ST3GAL1,MARCH5,UBX
ogic
N1,PWP1,FBXO32,BCL6,FUBP1,ZNF783,CMPK2,TBX2,ENOSF1,PTPN
al_p
22,MMS19,GBP3,SHMT2,ZFP91,CNTF,EEF2K,PLD1,VAPB,GPAA1,CU
roce
X1,PGS1,RBM17,CLNS1A,NUP98,EED,AMT,FMR1,SMPD4,SMAD7,MC
ss
F2L,USP4,PPFIBP2,HDAC6,ARHGEF12,EHMT1,ATP6V1D,VRK2,RNH1
,ZNF496,TYW1B,DERL2,NARS,LANCL2,H6PD,DGKA,TTLL3,PRMT10,P
NKP,LEF1,GLS,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,RGL
4,RBPMS,XYLT1,STARD13,ZSCAN31,XBP1,FDPS,PAM,ABCC1,NOM1,
SNRNP70,HSD17B12,DDX23,RAD23A,METTL3,APITD1,MPDU1,MARK
1.12
518
999
2
9.
1
6
E
0
9
4,UHMK1,USP47,ADAM8,NOL3,POLR3E,GABPB1,PRPF40A,DNAJC10,
RNF220,RAB35,PCGF6,RANBP1,SIPA1L1,MARCH6,DDX39A,KRIT1,SK
IV2L,MINK1,RHOF,PTPN6,SUGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UP
F3A,NOD1,PRKACA,STAT2,ANAPC4,RPP14,DHX9,PIGS,PLK1,ZNF446
,PNPO,PDE7B,ASNS,TBC1D2B,JAG2,DNM1L,TXNL1,PTGES2,UPF1,Z
NF621,HDGF,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1,CCNL1,HERC2,
CHD6,ZC3H12A,TBC1D10B,SEPT4,MIB2,POLM,SLC11A2,SYMPK,EFT
UD2,FAM58A,RAB24,ATG4B,CNP,CLN8,TBX18,PIGN,GCDH,LBX2,PC
GF1,DR1,BCLAF1,CAMK2D,ZNF721,ZNF397,JHDM1D,SLC16A1,ZNF7
10,GIGYF2,DNPEP,TBC1D14,GALK2,PRPF3,TNK2,USP20,GIT2,DCAF
11,WAC,STK4,ZNF142,FUBP3,MTG1,RARS,ZNF540,ALDH18A1,COPS
7B,FGFR1,RAB18,HSF4,PAIP1,CAPRIN1,GTF3C1,ERH,NADSYN1,PM
S1,ADCY4,CELF1,SNCAIP,PDE4D,RNASET2,SF3A2,TIMM23,PAF1,TA
B2,SGK1,PLEKHG4,SHARPIN,DPF2,CPT1B,CHKB,NADK,IDI1,RNF8,C
YP2R1,SEC31A,MDM2,RHBDD1,FKBP1A,ZFYVE26,PRKCH,MTMR11,
ANAPC16,PPM1F,ZNF595,TBP,DIS3L,IDH3G,YY1,FAM13A,INO80,GPA
T2,GMEB2,SSH2,MCFD2,PFDN5,TTC1,CREB1,NPTN,SRP9,RALGPS2,
NAGK,FLII,PLEKHG5,QSOX1,RPRD1A,DDX58,ALDH6A1,RPL27,ZCCH
C9,CCNL2,PTPRK,SNX13,RHBDF1,NF1,ZEB1,ACAA1,NEK3,EIF4B,NU
B1,IFITM3,ASCC2,ATG12,SPSB3,RGMB,RTKN,EBF1,RPL9,MED28,PH
F15,FKBP10,UNKL,NPR1,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKB
H3,ADSL,ALG6,ST3GAL4,BRD9,DCAF8,GCNT2,NTPCR,ZNF837,PKD2,
HNRNPA3,RXRB,GALT,UBE2Q1,NEDD8MDP1,MDP1,UBAC1,LMNA,RSL1D1,MITF,NOL8,USP24,RB1,PRMT5,H
MGXB3,LTBP4,MAPK8IP3,RABGGTA,GNAI1,USP3,MZF1,ZFPM2,TP53
BP1,RNF168,MARK3,PAFAH1B1,ZNF865,SENP2,ISYNA1,EDEM2,GPC
PD1,IL18,PUM2,RNF217,STARD3,TPP1,SYTL2,SUB1,CHMP1A,PDE8A
,NSA2,AACS,STK38L,DDX6,ACAP2,ZNF558,GALNT2,SH3BP5,MUM1,U
SP33,ZNF263,ZNF180,BICD1,NTMT1,LYSMD4,ZNF276,RGS3,NR1H3,
GARS,CYTH2,GRB10,MRPS7,PLK2,PAN2,HEXA,USP7,PLD6,FLCN,NR
P1,CUL4A,ZNF605,CHFR,ZNF410,PTGR2,TENC1,FMO2,GMDS,RPL24,
ARHGAP9,UST,MTMR14,RPL37A,SAP30BP,MAST2,VPS72,PTEN,FYN,
G
O:
00
31
98
1
nuclear lumen
ALDH1A3,IDH1,SRPK1,RNASEK,RUNX2,CSTF1,IQGAP1,FBXW7,PHP
T1,INTS4,PTP4A2,SMARCD3,HERPUD1,IKBKB,CTNS,RQCD1,PXN,KP
NB1,SRGAP2,RFX7,PTPRF,NCOR1,ATP11B,PPP1R10,MEF2A,OXCT1,
PARN,FECH,PRKRIP1,SETD8,COX7A2L,SMEK1,STK19,NECAB3,PIAS
2,SSBP1,MAPK8,MYCBP2,MYLK,USP15,DDX41,MAN1A2,SRRM2,PBX
3,RNF213,N6AMT1,ZNF565,ABCA2,AFF4,TRIM28,DENND4C,DMTF1,M
AP4K4,CSK,CDK5RAP2,PTPRS,ITPA,PTPRC,OAZ1,PSMC6,SWAP70,T
BCD,IMPDH1,RNF146,UBP1,SKIV2L2,CDK6,AGBL5,RARRES2,WDR61
,EBF4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,ARHGAP29,SG
SM3,STAG2,UBA2,AAK1,SP110,GOPC,PPA2,ST6GALNAC5,PHKG2
RNASEH2B,CRBN,OBFC1,PBX2,GTF3C2,PSMB10,EPHX2,UTRN,NOC
2L,PPIL2,PPP1R13B,RSC1A1,CDK13,SIN3B,CBX5,SART1,CCDC91,RA
B34,SUPT5H,SUPT20H,RILPL1,BCL6,FUBP1,CMPK2,TBX2,MMS19,ZF
P91,CUX1,RBM17,NUP98,EED,FMR1,SMAD7,HDAC6,ZNF496,SYTL4,
PNKP,LEF1,PAX8,SUPT4H1,PSMB9,XBP1,CPM,FDPS,ABCC1,NOM1,S
NRNP70,DDX23,METTL3,APITD1,NOL3,POLR3E,PRPF40A,SUGP1,CS
NK2A1,UPF3A,STAT2,ANAPC4,DHX9,PLK1,HDGF,PDXK,CCNL1,ZC3H
12A,SEPT4,SYMPK,EFTUD2,PCGF1,DR1,BCLAF1,CAMK2D,FYTTD1,J
HDM1D,PRPF3,GIT2,WAC,MTG1,RARS,GTF3C1,SNCAIP,SF3A2,PAF1
cell
,DPF2,MDM2,SNAP23,DAZAP1,TBP,IDH3G,YY1,INO80,GMEB2,CREB1
ular
,FLII,RPRD1A,ALDH6A1,CCNL2,ZEB1,NUMA1,RPL9,MED28,PHF15,ZN
_co
F3,RPS6KA5,ALKBH3,HNRNPA3,RXRB,LMNA,RSL1D1,NOL8,RB1,US
mpo
P3,STX16,ZFPM2,TP53BP1,PAFAH1B1,SENP2,RPS19BP1,CALCOCO
nent
2,SUB1,PWP2,CHMP1A,NSA2,SYNE1,STK38L,ZNF263,NTMT1,NR1H3,
USP7,CHFR,SAP30BP,PTEN,SRPK1,RUNX2,CSTF1,IQGAP1,FBXW7,I
NTS4,SMARCD3,KPNB1,NCOR1,MEF2A,PARN,PRKRIP1,PIAS2,MAPK
8,DDX41,MAN1A2,SRRM2,PBX3,AFF4,TRIM28,DMTF1,PSMC6,RPF2,S
KIV2L2,WDR61,PRPF8,APPL2,ZNF148,WDR13,PSMC4,HNRNPL,STA
G2,SP110,ATPAF2,HNRNPH3,TCF4,ACD,WDR4,ATP6V0A1,TIMM50,D
GKZ,NFYC,SRSF10,SMAD4,TGFB1I1,INO80E,EZR,RPL4,MTRR,ZNF44
,AUP1,ING4,ZNF687,CDC14B,CLK3,NR2C2,FIP1L1,DNTTIP2,IRF9,SU
N2,MSL1,GLI3,ADD3,MAPK12,ENG,SIRT7,TCF12,ARNT,ERCC1,PHF1,
1.36
929
980
8
9.
8
8
E
0
9
G
O:
00
06
79
3
phosphorus metabolic process
PRELID1,PHF12,REXO2,MED6,CIRBP,RGS2,HINFP,STAM2,NCBP2,T
GS1,NCAPD3,RAD51B,FAM76B,BDP1,DBF4,RUNX1,MKNK2,SMARCA
4,LMNB1,NAA16,LRPPRC,SDAD1,SNX27,ZNF638,DCAF17,KLHL7,SN
RPE,NCOR2,KANSL3,PRPF4B,FTSJ3,NARF,TROVE2,ATXN3,MAU2,P
HF21A,PDCD4,PSMA1,STAT6,ACIN1,SON,CLIC4,BTBD10,PNISR,SPR
ED1,BRWD1,SMAD9,DUSP6,ZBTB16,BAZ2A,RRP8,PHF19,SEPT2,LUC
7L3,SENP6,PDPK1,TSG101,USF1,FOXC1,KPNA1,ZC3H14,STK24,PHC
2,SMARCAD1,SYCP2L,ZC3H15,GATA2,PABPN1
CDK14,CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,CKB,IGF1R,GK5,M
YO1D,SIRT2,EPHX2,RALGAPA2,RAF1,SEPT5,CDK13,BDNF,TAZ,ATP2
B1,PLCD1,RAB34,ST3GAL1,BCL6,CMPK2,PTPN22,GBP3,ZFP91,CNTF
,EEF2K,PLD1,VAPB,GPAA1,PGS1,SMPD4,SMAD7,MCF2L,ARHGEF12,
ATP6V1D,VRK2,H6PD,DGKA,PNKP,ARHGEF25,RGL4,RBPMS,STARD
13,XBP1,FDPS,ABCC1,HSD17B12,DDX23,MARK4,UHMK1,ADAM8,DN
AJC10,RAB35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,
PTPN6,EEF1A1,CSNK2A1,IGBP1,NOD1,PRKACA,DHX9,PIGS,PLK1,P
NPO,PDE7B,ASNS,TBC1D2B,DNM1L,UPF1,HDGF,FDXR,PPP5C,PIGG
,PDXK,CCNL1,HERC2,CHD6,TBC1D10B,SEPT4,SYMPK,EFTUD2,FAM
biol
58A,CNP,CLN8,PIGN,GCDH,CAMK2D,TBC1D14,GALK2,TNK2,GIT2,ST
ogic
K4,MTG1,ALDH18A1,FGFR1,RAB18,NADSYN1,PMS1,ADCY4,PDE4D,T
al_p
AB2,SGK1,PLEKHG4,CHKB,NADK,IDI1,SEC31A,FKBP1A,PRKCH,MTM
roce
R11,PPM1F,FAM13A,INO80,GPAT2,SSH2,CREB1,NPTN,RALGPS2,NA
ss
GK,PLEKHG5,RPRD1A,DDX58,ZCCHC9,CCNL2,PTPRK,SNX13,NF1,N
EK3,RTKN,NPR1,RPS6KA5,G3BP1,RAB31,ADSL,NTPCR,PKD2,GALT,
NEDD8MDP1,MDP1,LMNA,RB1,HMGXB3,LTBP4,MAPK8IP3,GNAI1,MARK3,P
AFAH1B1,SENP2,ISYNA1,GPCPD1,TPP1,SYTL2,PDE8A,STK38L,DDX
6,ACAP2,SH3BP5,RGS3,GARS,CYTH2,GRB10,PLK2,HEXA,PLD6,FLC
N,NRP1,TENC1,FMO2,GMDS,ARHGAP9,MTMR14,MAST2,PTEN,FYN,I
DH1,SRPK1,IQGAP1,FBXW7,PHPT1,PTP4A2,HERPUD1,IKBKB,CTNS,
PXN,SRGAP2,PTPRF,ATP11B,PPP1R10,MEF2A,FECH,PRKRIP1,SME
K1,STK19,MAPK8,MYLK,USP15,DDX41,RNF213,ABCA2,TRIM28,DENN
1.30
281
429
1
1.
1
5
E
0
8
G
O:
00
06
79
6
phosphate-containing compound metabolic
process
D4C,MAP4K4,CSK,PTPRS,ITPA,PTPRC,PSMC6,TBCD,IMPDH1,SKIV2
L2,CDK6,PSMC4,ARHGAP29,SGSM3,AAK1,GOPC,PPA2,PHKG2,PAK1
,NCK2,RHEB,MTMR9,TRPM7,SEMA4D,GNB3,CSF1R,ERC1,TIMM50,D
GKZ,C3,HSD17B4,ELOVL1,SMAD4,GRPEL2,TBC1D22A,DTYMK,MBOA
T2,CDC14B,CLK3,DLST,RAB5A,ATP5A1,TMED2,THNSL2,NDUFV1,MA
PK12,NDUFS2,RASGRF2,AK5,ENG,NOX4,NRBP2,STK36,ATP8B2,ARH
GEF7,PDIA5,ASAP1,REXO2,MDFI,IDH3B,PTPRD,ITGA5,RGS2,LPCAT
1,PDGFRB,PTPN4,RAD51B,CDK11A,CARD14,FARP1,TNFRSF14,RAP
1B,MKNK2,SMARCA4,YIF1A,DHX40,ACYP2,PTPN23,CLK4,TLN1,DOC
K8,ADRBK2,LONRF3,GSK3A,SIK3,TWF1,PCYT1A,PIGO,PPAP2A,PRP
F4B,IGF2,MYO1E,PSTK,GPHN,PDCD4,PGM2,RGL2,CHD2,CRIPAK,LO
NP2,ACIN1,PSD3,CSNK1E,CDK5RAP1,BNIP2,NTRK1,SPRED1,TNFRS
F10B,PHKG1,SMAD9,DUSP6,TGFBR3,UCK1,DHX37,UQCRH,PKD1,PD
PK1,STK24,SSH1,CDK5RAP3,RAPGEF6,GAK,ALG9,RBKS,PANK3,FAS
TK,EYA2,SMARCAD1,WNK1,DENND6B,PLA2G16
CDK14,CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,CKB,IGF1R,GK5,M
YO1D,SIRT2,EPHX2,RALGAPA2,RAF1,SEPT5,CDK13,BDNF,TAZ,ATP2
B1,PLCD1,RAB34,ST3GAL1,BCL6,CMPK2,PTPN22,GBP3,ZFP91,CNTF
,EEF2K,PLD1,VAPB,GPAA1,PGS1,SMPD4,SMAD7,MCF2L,ARHGEF12,
ATP6V1D,VRK2,H6PD,DGKA,PNKP,ARHGEF25,RGL4,RBPMS,STARD
13,XBP1,FDPS,ABCC1,DDX23,MARK4,UHMK1,ADAM8,DNAJC10,RAB
biol 35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,PTPN6,EE
ogic F1A1,CSNK2A1,IGBP1,NOD1,PRKACA,DHX9,PIGS,PLK1,PNPO,PDE7
al_p B,ASNS,TBC1D2B,DNM1L,UPF1,HDGF,FDXR,PPP5C,PIGG,PDXK,CC
roce NL1,HERC2,CHD6,TBC1D10B,SEPT4,SYMPK,EFTUD2,FAM58A,CNP,
ss
CLN8,PIGN,CAMK2D,TBC1D14,GALK2,TNK2,GIT2,STK4,MTG1,ALDH1
8A1,FGFR1,RAB18,NADSYN1,PMS1,ADCY4,PDE4D,TAB2,SGK1,PLEK
HG4,CHKB,NADK,IDI1,SEC31A,FKBP1A,PRKCH,MTMR11,PPM1F,FAM
13A,INO80,GPAT2,SSH2,CREB1,NPTN,RALGPS2,NAGK,PLEKHG5,RP
RD1A,DDX58,ZCCHC9,CCNL2,PTPRK,SNX13,NF1,NEK3,RTKN,NPR1,
RPS6KA5,G3BP1,RAB31,ADSL,NTPCR,PKD2,GALT,NEDD8MDP1,MDP1,LMNA,RB1,HMGXB3,LTBP4,MAPK8IP3,GNAI1,MARK3,P
1.30
029
728
8
1.
9
5
E
0
8
G
O:
00
05
63
4
nucleus
AFAH1B1,SENP2,ISYNA1,GPCPD1,TPP1,SYTL2,PDE8A,STK38L,DDX
6,ACAP2,SH3BP5,RGS3,GARS,CYTH2,GRB10,PLK2,HEXA,PLD6,FLC
N,NRP1,TENC1,FMO2,GMDS,ARHGAP9,MTMR14,MAST2,PTEN,FYN,I
DH1,SRPK1,IQGAP1,FBXW7,PHPT1,PTP4A2,HERPUD1,IKBKB,CTNS,
PXN,SRGAP2,PTPRF,ATP11B,PPP1R10,MEF2A,FECH,PRKRIP1,SME
K1,STK19,MAPK8,MYLK,USP15,DDX41,RNF213,ABCA2,TRIM28,DENN
D4C,MAP4K4,CSK,PTPRS,ITPA,PTPRC,PSMC6,TBCD,IMPDH1,SKIV2
L2,CDK6,PSMC4,ARHGAP29,SGSM3,AAK1,GOPC,PPA2,PHKG2,PAK1
,NCK2,RHEB,MTMR9,TRPM7,SEMA4D,GNB3,CSF1R,ERC1,TIMM50,D
GKZ,C3,SMAD4,GRPEL2,TBC1D22A,DTYMK,MBOAT2,CDC14B,CLK3,
RAB5A,ATP5A1,TMED2,THNSL2,NDUFV1,MAPK12,NDUFS2,RASGRF
2,AK5,ENG,NOX4,NRBP2,STK36,ATP8B2,ARHGEF7,PDIA5,ASAP1,RE
XO2,MDFI,IDH3B,PTPRD,ITGA5,RGS2,LPCAT1,PDGFRB,PTPN4,RAD
51B,CDK11A,CARD14,FARP1,TNFRSF14,RAP1B,MKNK2,SMARCA4,YI
F1A,DHX40,ACYP2,PTPN23,CLK4,TLN1,DOCK8,ADRBK2,LONRF3,GS
K3A,SIK3,TWF1,PCYT1A,PIGO,PPAP2A,PRPF4B,IGF2,MYO1E,PSTK,
GPHN,PDCD4,PGM2,RGL2,CHD2,CRIPAK,LONP2,ACIN1,PSD3,CSNK
1E,CDK5RAP1,BNIP2,NTRK1,SPRED1,TNFRSF10B,PHKG1,SMAD9,D
USP6,TGFBR3,UCK1,DHX37,UQCRH,PKD1,PDPK1,STK24,SSH1,CDK
5RAP3,RAPGEF6,GAK,ALG9,RBKS,PANK3,FASTK,EYA2,SMARCAD1,
WNK1,DENND6B,PLA2G16
MARVELD1,CDK14,USP10,RNASEH2B,CRBN,OBFC1,PBX2,LPP,GTF3
C2,RAI1,PSMB10,SIRT2,EPHX2,UTRN,RALGAPA2,MYNN,TRNAU1AP,
RAI14,NOC2L,PPIL2,RAF1,NLRP1,ZNF131,LEPRE1,SLC16A3,PPP1R1
cell 3B,RSC1A1,SFSWAP,CDK13,RBM6,SIN3B,SPOP,CPE,CBX5,SART1,C
ular CDC91,RAB34,SUPT5H,SUPT20H,RILPL1,UBXN1,PWP1,FBXO32,LUC
_co 7L,BCL6,FUBP1,ZNF783,CMPK2,TBX2,PTPN22,MMS19,ZFP91,CUX1,
mpo RBM17,CLNS1A,NUP98,EED,FMR1,SMAD7,USP4,HDAC6,EHMT1,VRK
nent 2,ZNF496,IL15RA,LANCL2,SYTL4,PNKP,LEF1,PAX8,SUPT4H1,ZNF83,
PSMB9,EMX2,BCL2L13,RBPMS,ZSCAN31,STARD9,XBP1,CPM,FDPS,
ABCC1,NOM1,SNRNP70,DDX23,RAD23A,METTL3,APITD1,UHMK1,NO
L3,POLR3E,GABPB1,PRPF40A,XAF1,PCGF6,RANBP1,DDX39A,KPNA
1.20
680
712
7
2.
9
6
E
0
8
6,SKIV2L,PTPN6,SUGP1,EEF1A1,LHX4,CMIP,CSNK2A1,UPF3A,PRKA
CA,STAT2,ANAPC4,RPP14,DHX9,PLK1,ZNF446,NUTF2,TXNL1,PTGES
2,UPF1,ZNF621,HDGF,PPP5C,PDXK,NPC1,SHISA5,CCNL1,HERC2,CH
D6,ZC3H12A,NUP210,SEPT4,POLM,SLC11A2,DIP2A,SYMPK,EFTUD2,
TBX18,LBX2,PCGF1,DR1,BCLAF1,CAMK2D,FYTTD1,ZNF721,ZNF397,
JHDM1D,ZNF710,PLCB4,PRPF3,TNK2,GIT2,WAC,STK4,ZNF142,FUBP
3,TRO,MTG1,RARS,ZNF540,COPS7B,FGFR1,HSF4,GTF3C1,PMS1,CE
LF1,SNCAIP,SF3A2,PAF1,SGK1,DPF2,RNF8,CDYL2,MDM2,SNAP23,D
AZAP1,ANAPC16,ZNF595,TBP,IDH3G,YY1,INO80,GMEB2,PFDN5,CRE
B1,FLII,RPRD1A,CCNDBP1,ALDH6A1,CCNL2,NF1,ZEB1,NEK3,SERBP
1,SETBP1,NUB1,NUMA1,EBF1,RPL9,MED28,PHF15,UNKL,ZNF3,RPS6
KA5,G3BP1,NIPBL,ALKBH3,ZNF837,CASP2,HNRNPA3,RXRB,LMNA,N
UDT6,RSL1D1,MITF,NOL8,PPP2R3C,RB1,PRMT5,HMGXB3,GNAI1,US
P3,PLEKHA2,STX16,MZF1,ZFPM2,TP53BP1,RNF168,PAFAH1B1,ZNF8
65,SENP2,RPS19BP1,SLFN11,CALCOCO2,SYTL2,SUB1,PWP2,CHMP
1A,NSA2,SYNE1,STK38L,ZNF558,MUM1,ZNF263,ZNF180,BICD1,NTM
T1,ZNF276,RGS3,GCC2,NR1H3,PAN2,USP7,FLCN,ZNF605,CHFR,ZNF
410,SAP30BP,VPS72,PTEN,FYN,SRPK1,RUNX2,CSTF1,IQGAP1,FBX
W7,INTS4,SMARCD3,IKBKB,RQCD1,GGNBP2,KPNB1,SRGAP2,RFX7,
NCOR1,ATP11B,PPP1R10,MEF2A,DYM,PARN,ZMYM5,PRKRIP1,SETD
8,SMEK1,STK19,NECAB3,PIAS2,FIBP,MAPK8,MYCBP2,USP15,DDX41
,MAN1A2,SRRM2,OSBPL3,PBX3,ZNF565,AFF4,TRIM28,DMTF1,PSMC
6,SWAP70,RPF2,IMPDH1,RNF146,UBP1,SKIV2L2,DSN1,CDK6,NSFL1
C,AGBL5,WDR61,EBF4,NUP37,PRPF8,APPL2,ZNF148,ZNF76,FLOT1,
WDR13,CPSF3L,PSMC4,HNRNPL,STAG2,UBA2,SP110,RANBP9,ATPA
F2,PAK1,RHEB,HNRNPH3,ZSWIM7,TCF4,ACD,IKZF5,HMGN2,WDR4,S
SBP2,ATP6V0A1,TIMM50,DGKZ,NFYC,ZNF609,PIWIL4,SRSF10,SS18,
RCOR3,SMAD4,MEMO1,ZNF114,MIER2,TGFB1I1,INO80E,EZR,ASB8,R
PL4,MTRR,CENPT,ZNF44,AUP1,CREBZF,GOLPH3,ING4,RBMS1,ZNF6
87,CDC14B,CLK3,NR2C2,FHOD1,FIP1L1,DLST,DNTTIP2,FLNA,IRF9,S
UN2,BCAS3,MSL1,ATP5A1,GLI3,ADD3,MAPK12,CCDC59,DCAF6,EPS
15L1,EPN1,THOC2,VEZT,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,Z
G
O:
00
03
82
4
catalytic activity
mol
ecul
ar_f
unct
ion
NF692,GAPDH,ERCC1,PHF1,PRELID1,STK36,WWP1,PHF12,REXO2,M
ED6,MDFI,CIRBP,NUP85,ZNF554,NAA10,CIZ1,RGS2,HINFP,STAM2,N
CBP2,MLX,PDGFRB,TGS1,DZIP1,NCAPD3,RAD51B,CDK11A,GLIS3,N
OB1,FAM76B,BDP1,DBF4,RUNX1,MKNK2,TRIM41,SMARCA4,LMNB1,
NAA16,LRPPRC,RPLP0,SDAD1,RAD54L2,CLASRP,SNX27,ZNF518B,P
TPN23,CRCP,CLK4,ZNF90,ZNF638,PER3,FGF14,DCAF17,CHTF8,KLH
L7,PHC3,SNRPE,ANKRD6,ZNF383,POLR2J3,NCOR2,SETD2,S100PBP
,KANSL3,PRPF4B,PTGIS,FTSJ3,NARF,WDFY3,TROVE2,ATXN3,MAU2,
PHF21A,PDCD4,SOX13,CHD2,CRIPAK,LONP2,PSMA1,STAT6,ACIN1,
CSNK1E,SON,ZNF138,CLIC4,ZNF705A,NSMCE4A,BNIP2,BTBD10,PNI
SR,SHPRH,SPRED1,BRWD1,SMAD9,DUSP6,LIMS2,ZBTB16,BAZ2A,R
RP8,PHF19,LMCD1,SEPT2,LUC7L3,SENP6,PKD1,PDPK1,TSG101,USF
1,FOXC1,ARL6IP4,KPNA1
CDK14,USP10,CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,PSMB10,XR
N1,CKB,IGF1R,GK5,PTS,MYO1D,SIRT2,EPHX2,RALGAPA2,PPIL2,TAR
S,RAF1,NLRP1,SEPT5,LEPRE1,DDI2,CDK13,TAZ,ATP2B1,CPE,PLCD1
,RAB34,ERCC6L2,ST3GAL1,MARCH5,DPP4,BCL6,CMPK2,ENOSF1,PT
PN22,GBP3,SPATA20,SHMT2,ZFP91,EEF2K,PLD1,VAPB,NLN,GPAA1,
PGS1,PARP6,EED,SLC9B2,AMT,SMPD4,SMAD7,MCF2L,USP4,PPFIBP
2,HDAC6,ARHGEF12,EHMT1,ATP6V1D,VRK2,DYNC1I1,RNH1,TYW1B,
CASP4,NARS,LANCL2,H6PD,DGKA,TTLL3,PRMT10,PNKP,LEF1,GLS,
PSMB9,ARHGEF25,ADAMTS1,RGL4,BCL2L13,BCL2L11,XYLT1,STAR
D13,STARD9,XBP1,CPM,FDPS,PAM,ABCC1,GLT8D1,HSD17B12,DDX2
3,METTL3,SCRN3,MARK4,UHMK1,USP47,ADAM8,POLR3E,DNAJC10,
RNF220,RAB35,RANBP1,SIPA1L1,MARCH6,DDX39A,KRIT1,SKIV2L,MI
NK1,RHOF,PTPN6,EEF1A1,CSNK2A1,IGBP1,NOD1,PRKACA,ANAPC4,
RPP14,DHX9,PIGS,PLK1,PNPO,PDE7B,PREPL,ASNS,TBC1D2B,ECHD
C1,DNM1L,TXNL1,PTGES2,UPF1,HDGF,FDXR,RC3H1,PPP5C,PIGG,P
DXK,CCNL1,HERC2,CHD6,ZC3H12A,TBC1D10B,SEPT4,MIB2,POLM,S
LC11A2,DIP2A,EFTUD2,FAM58A,ATG4B,CNP,CLN8,PIGN,GCDH,CAM
K2D,JHDM1D,PLCB4,DHRSX,DNPEP,TBC1D14,GALK2,TNK2,ENGASE
,USP20,GIT2,STK4,MTG1,RARS,ALDH18A1,MAN2C1,FGFR1,RAB18,C
1.17
152
548
1
5.
7
9
E
0
8
2,CFB,MMP16,NADSYN1,PMS1,ADCY4,PDE4D,RNASET2,TAB2,SGK1,
PLEKHG4,CPT1B,CHKB,NADK,IDI1,RNF8,CDYL2,CYP2R1,SEC31A,M
DM2,KCMF1,RHBDD1,FKBP1A,PRKCH,MTMR11,PPM1F,DIS3L,IDH3G
,FAM13A,INO80,GPAT2,SSH2,CREB1,RALGPS2,NAGK,PLEKHG5,QS
OX1,DDX58,ALDH6A1,ZCCHC9,CCNL2,PTPRK,SNX13,RHBDF1,SERP
INH1,NF1,ACAA1,NEK3,RTKN,FKBP10,UNKL,NPR1,RPS6KA5,G3BP1,
RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,CAPN10,GCNT2,NTPCR,PKD2,
CASP2,GALT,UBE2Q1,NEDD8MDP1,MDP1,LMNA,NUDT6,USP24,RB1,PRMT5,HMGXB3,LTBP4,MAP
K8IP3,RABGGTA,GNAI1,USP3,DHRS1,CPPED1,TXNDC5,RNF168,MA
RK3,PAFAH1B1,SENP2,ISYNA1,EDEM2,GPCPD1,MTCH1,RNF217,TP
P1,SYTL2,DNALI1,CHMP1A,PDE8A,AACS,STK38L,DDX6,ACAP2,ANX
A5,GALNT2,ADAM15,SH3BP5,USP33,BICD1,NTMT1,RGS3,NR1H3,GA
RS,CYTH2,PLK2,PAN2,HEXA,USP7,PLD6,NRP1,CHFR,PTGR2,TENC1,
FMO2,GMDS,ARHGAP9,UST,MTMR14,MAST2,FAP,PTEN,FYN,ALDH1
A3,IDH1,SRPK1,RNASEK,IQGAP1,C1R,FBXW7,PHPT1,PTP4A2,LGMN,
HERPUD1,IKBKB,PXN,ADAMTS18,SRGAP2,PTPRF,NCOR1,ATP11B,P
PP1R10,MEF2A,OXCT1,PARN,FECH,PRKRIP1,SETD8,COX7A2L,TME
M189,STK19,PIAS2,SSBP1,MAPK8,MYCBP2,MYLK,USP15,DDX41,MA
N1A2,RNF213,N6AMT1,ABCA2,TRIM28,DENND4C,MAP4K4,CSK,CP,P
TPRS,ITPA,PTPRC,OAZ1,PSMC6,TBCD,IMPDH1,RNF146,SKIV2L2,CD
K6,ALDH16A1,AGBL5,DDHD2,FARSA,ABHD16A,CPSF3L,PSMC4,KIFC
2,ARHGAP29,SGSM3,OGFOD3,UBA2,AAK1,GOPC,PPA2,ST6GALNAC
5,PHKG2,PAK1,NCK2,LEPR,RHEB,MTMR9,CTSH,ACD,TRPM7,WDR4,
SEMA4D,GNB3,CSF1R,TIMM50,DGKZ,C3,ALDH3B1,P4HB,HSD17B4,E
LOVL1,FUT4,RPUSD4,GRPEL2,FNTB,CHURC1FNTB,TBC1D22A,KLC1,NAV1,DDAH1,DTYMK,MTRR,MBOAT2,USP54,
CDC14B,CLK3,DNHD1,DLST,RAB5A,CA5B,HGSNAT,MGAT5,BCS1L,C
1S,ATP5A1,TMED2,THNSL2,NDUFV1,MAPK12,NDUFS2,RASGRF2,AK
5,GUSB,B4GALT4,ENG,SIRT7,PCSK7,NOX4,ETFA,EXT1,GAPDH,ERC
C1,GAA,NRBP2,B3GAT3,STK36,SDHA,WWP1,ATP8B2,ARHGEF7,PDI
A5,NAT9,ASAP1,REXO2,MDFI,UBA6,RABGGTB,IDH3B,PTGR1,NUBP1
G
O:
00
16
04
3
cellular component organization
,NAA10,PTPRD,RGS2,MAN2A2,LPCAT1,PDGFRB,EBPL,PTPN4,TGS1,
RAD51B,CDK11A,MAN1B1,NIT1,CARD14,DIABLO,ENO4,MYO7B,FARP
1,DBF4,RAP1B,MKNK2,TRIM41,SMARCA4,NAA16,USP40,YIF1A,DHX4
0,RAD54L2,ACYP2,KIF13B,PTPN23,RHBDF2,CRCP,CLK4,TLN1,DOCK
8,ADRBK2,LONRF3,GSK3A,SIK3,THUMPD2,NLGN2,POLG,POLR2J3,T
TLL11,FBXW2,FPGS,SETD2,TWF1,ATG4A,PCYT1A
FZD6,CRBN,OBFC1,CADM1,PSMB10,CLMN,IGF1R,LAMB1,NPHP3,SIR
T2,NOC2L,RAF1,F11R,LEPRE1,COL9A1,SFSWAP,CDK13,BDNF,TAZ,
CPE,SART1,COL2A1,RAB34,SUPT5H,MARCH5,DPP4,BCL6,MMS19,S
HMT2,GPAA1,CLNS1A,NUP98,EED,SMAD7,HDAC6,ARHGEF12,EHMT
1,ATP6V1D,HGS,DERL2,CD72,TTLL3,ARPC4TTLL3,LEF1,GLS,PAX8,SUPT4H1,ITGA9,BCL2L11,STARD9,COG4,NIS
CH,PAM,CEP135,HSD17B12,DDX23,APITD1,MARK4,UHMK1,USP47,A
DAM8,CAPZB,PRPF40A,CD9,RANBP1,SIPA1L1,MINK1,PDLIM5,RHOF,
ACTR3,LHX4,VASP,CSNK2A1,NOD1,PRKACA,ANAPC4,PLK1,COL16A
1,TTC19,DNM1L,UPF1,RC3H1,PPP5C,CHD6,SEPT4,SLC11A2,ATG4B,
CNP,CLN8,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,JHDM1D,BBS1,TBC
biol
1D14,TNK2,COL14A1,WAC,STK4,TRO,FGFR1,HPS4,HSF4,DISP1,CAP
ogic
RIN1,MMP16,CELF1,SNCAIP,SF3A2,TIMM23,PAF1,SGK1,SHARPIN,T
al_p
CHP,RNF8,KIAA0586,SEC31A,MDM2,SNAP23,COL12A1,FKBP1A,PRK
roce
CH,ANAPC16,PPM1F,YY1,TLN2,INO80,SSH2,CREB1,NPTN,RPL27,PT
ss
PRK,SERPINH1,LIMCH1,MAGI1,NF1,PIH1D1,NEK3,ATG12,NUMA1,RG
MB,COL18A1,RPL9,PHF15,NPR1,RPS6KA5,NIPBL,RAB31,ADSL,BRD9
,CAPN10,PKD2,LMNA,MITF,NOL8,RB1,PRMT5,LTBP4,MAPK8IP3,GNA
I1,USP3,BLOC1S5,TXNDC5,NEXN,RNF168,PAFAH1B1,PUM2,MTCH1,
TPP1,CHMP1A,ARPC2,SYNE1,STK38L,DDX6,ADAM15,MUM1,USP33,
BICD1,NTMT1,GCC2,NR1H3,CYTH2,PLK2,HEXA,PLD6,FLCN,NRP1,C
HFR,RPL24,IGFBP6,DAAM1,RPL37A,FAP,VPS72,PTEN,FYN,SRPK1,F
BXW7,PHPT1,SMARCD3,IFT172,SNX17,PXN,KPNB1,SRGAP2,NCOR1,
ATP11B,MEF2A,DYM,TNS1,FECH,ERAL1,SETD8,WASH4P,TCTN1,SS
BP1,CACNB1,VILL,MAPK8,MYCBP2,CLTCL1,MYLK,N6AMT1,RAB8A,T
RIM28,DENND4C,CSK,CDK5RAP2,COL9A3,ITPA,PTPRC,TBCD,DSN1,
1.24
787
758
8.
7
5
E
0
8
G
O:
00
00
16
6
nucleotide binding
mol
ecul
ar_f
unct
ion
ABI3BP,WDR61,TSPAN4,NUP37,COX14,ZNF148,FLOT1,STAG2,AAK1,
GOPC,RANBP9,WDR35,ATPAF2,PARD6G,PAK1,NCK2,RAB10,SEMA6
A,TCF4,ACD,TRPM7,HMGN2,SEMA4D,CSF1R,ATP6V0A1,TIMM50,AC
TR2,C3,P4HB,SRSF10,ROBO3,SS18,SMAD4,GRPEL2,KLC1,C1QTNF3
,NAV1,TGFB1I1,EZR,RPL4,CENPT,GOLPH3,ING4,CDCA3,HPS3,FHOD
1,FLNA,RAB5A,SUN2,MSL1,HGSNAT,BCS1L,GLI3,TMED2,ENG,SIRT7,
NOX4,EXT1,GAPDH,ERCC1,VTI1B,PHF1,GAA,MTRF1L,SLC25A6,STK
36,ARHGEF7,TBCE,ASAP1,UNC5B,CIRBP,NUP85,NUBP1,NAA10,HAU
S5,PTPRD,ITGA5,STAM2,NCBP2,PDGFRB,COL8A1,TGS1,DZIP1,NCA
PD3,CDK11A,CC2D2A,FARP1,SMARCA4,LMNB1,RPLP0,SDAD1,KIF13
B,PTPN23,KCTD2,TLN1,GSK3A,SNRPE,NLGN2,POLG,SETD2,TWF1,K
ANSL3,COL13A1,IGF2,TROVE2,MYO1E,ATXN3,CORO7,AMFR,MAU2,
PHF21A,GPHN,CRIPAK,LONP2,TANC1,ACIN1,ROBO2,SON,CACNB3,
PMP22,KCTD17,CLIC4,BNIP2,NTRK1,TFAM,SHPRH,ATG3,BRWD1,HB
B,TGFBR3,TMEM237,LIMS2,CD151,BAZ2A,PLOD2,RRP8,PHF19,LETM
1,SEPT2,UQCRH,SENP6,PDPK1,TSG101,FOXC1,KPNA1,ACAN,STK24
,SSH1,FMOD,C2CD3,MTO1,UBR5,EYA2,SMARCAD1,CLASP1,TENM4,
GATA2,GORASP1
CDK14,DHX34,ACADVL,EIF2B4,CKB,IGF1R,GK5,TNRC6A,MYO1D,SIR
T2,TRNAU1AP,TARS,RAF1,NLRP1,SEPT5,CDK13,RBM6,ATP2B1,RAB
34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,RBM17,SLC9B2,MCF2L,ARH
GEF12,VRK2,TYW1B,NARS,LANCL2,H6PD,DGKA,PNKP,ARHGEF25,R
GL4,RBPMS,STARD9,ABCC1,SNRNP70,HSD17B12,DDX23,MARK4,UH
MK1,RAB35,RANBP1,DDX39A,SKIV2L,MINK1,RHOF,EEF1A1,ACTR3,C
SNK2A1,UPF3A,NOD1,PRKACA,DHX9,PLK1,PNPO,ASNS,DNM1L,UPF
1,HDGF,FDXR,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD2,RAB24,
CNP,GCDH,CAMK2D,DHRSX,GALK2,TNK2,STK4,MTG1,RARS,ALDH1
8A1,FGFR1,RAB18,NADSYN1,PMS1,ADCY4,CELF1,PDE4D,SGK1,PLE
KHG4,CHKB,NADK,PRKCH,DAZAP1,IDH3G,INO80,RALGPS2,NAGK,P
LEKHG5,DDX58,FAM114A2,MAGI1,NEK3,EIF4B,RTKN,NPR1,RPS6KA
5,G3BP1,RAB31,NTPCR,HNRNPA3,UBE2Q1,NOL8,GNAI1,DHRS1,MA
RK3,ISYNA1,SLFN11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,CHFR,
1.34
028
646
7
1.
1
5
E
0
7
G
O:
19
01
26
5
nucleoside phosphate binding
mol
ecul
ar_f
unct
ion
PTGR2,FMO2,GMDS,MAST2,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,IKBK
B,ATP11B,PARN,ERAL1,STK19,MAPK8,MYLK,DDX41,RNF213,ABCA2,
RAB8A,DENND4C,MAP4K4,CSK,ITPA,PSMC6,SWAP70,IMPDH1,SKIV2
L2,CDK6,FARSA,PSMC4,HNRNPL,KIFC2,UBA2,AAK1,PHKG2,PAK1,R
AB10,RHEB,HNRNPH3,TRPM7,CSF1R,DGKZ,ACTR2,HSD17B4,SRSF1
0,GRPEL2,NAV1,DTYMK,MTRR,RBMS1,CLK3,RAB5A,BCS1L,ATP5A1,
NDUFV1,MAPK12,NDUFS2,RASGRF2,AK5,SIRT7,NOX4,ETFA,GAPDH
,NRBP2,STK36,SDHA,ATP8B2,ARHGEF7,CIRBP,UBA6,IDH3B,PTGR1,
NUBP1,NCBP2,PDGFRB,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RU
NX1,MKNK2,SMARCA4,DHX40,RAD54L2,KIF13B,CRCP,CLK4,ZNF638,
DOCK8,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO1E,D2HGDH,
PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP2,CARS2,ACIN1,PSD3,
CSNK1E,NTRK1,SHPRH,PHKG1,SIRT3,UCK1,VARS,LARS,DHX37,SE
PT2,PDPK1,STK24,RAPGEF6,GAK,MTO1,PABPC1,RBKS,PANK3,FAS
TK,SMARCAD1,WNK1,DENND6B,PABPN1
CDK14,DHX34,ACADVL,EIF2B4,CKB,IGF1R,GK5,TNRC6A,MYO1D,SIR
T2,TRNAU1AP,TARS,RAF1,NLRP1,SEPT5,CDK13,RBM6,ATP2B1,RAB
34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,RBM17,SLC9B2,MCF2L,ARH
GEF12,VRK2,TYW1B,NARS,LANCL2,H6PD,DGKA,PNKP,ARHGEF25,R
GL4,RBPMS,STARD9,ABCC1,SNRNP70,HSD17B12,DDX23,MARK4,UH
MK1,RAB35,RANBP1,DDX39A,SKIV2L,MINK1,RHOF,EEF1A1,ACTR3,C
SNK2A1,UPF3A,NOD1,PRKACA,DHX9,PLK1,PNPO,ASNS,DNM1L,UPF
1,HDGF,FDXR,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD2,RAB24,
CNP,GCDH,CAMK2D,DHRSX,GALK2,TNK2,STK4,MTG1,RARS,ALDH1
8A1,FGFR1,RAB18,NADSYN1,PMS1,ADCY4,CELF1,PDE4D,SGK1,PLE
KHG4,CHKB,NADK,PRKCH,DAZAP1,IDH3G,INO80,RALGPS2,NAGK,P
LEKHG5,DDX58,FAM114A2,MAGI1,NEK3,EIF4B,RTKN,NPR1,RPS6KA
5,G3BP1,RAB31,NTPCR,HNRNPA3,UBE2Q1,NOL8,GNAI1,DHRS1,MA
RK3,ISYNA1,SLFN11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,CHFR,
PTGR2,FMO2,GMDS,MAST2,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,IKBK
B,ATP11B,PARN,ERAL1,STK19,MAPK8,MYLK,DDX41,RNF213,ABCA2,
RAB8A,DENND4C,MAP4K4,CSK,ITPA,PSMC6,SWAP70,IMPDH1,SKIV2
1.33
977
117
1
1.
1
9
E
0
7
G
O:
00
05
82
9
cytosol
L2,CDK6,FARSA,PSMC4,HNRNPL,KIFC2,UBA2,AAK1,PHKG2,PAK1,R
AB10,RHEB,HNRNPH3,TRPM7,CSF1R,DGKZ,ACTR2,HSD17B4,SRSF1
0,GRPEL2,NAV1,DTYMK,MTRR,RBMS1,CLK3,RAB5A,BCS1L,ATP5A1,
NDUFV1,MAPK12,NDUFS2,RASGRF2,AK5,SIRT7,NOX4,ETFA,GAPDH
,NRBP2,STK36,SDHA,ATP8B2,ARHGEF7,CIRBP,UBA6,IDH3B,PTGR1,
NUBP1,NCBP2,PDGFRB,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RU
NX1,MKNK2,SMARCA4,DHX40,RAD54L2,KIF13B,CRCP,CLK4,ZNF638,
DOCK8,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO1E,D2HGDH,
PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP2,CARS2,ACIN1,PSD3,
CSNK1E,NTRK1,SHPRH,PHKG1,SIRT3,UCK1,VARS,LARS,DHX37,SE
PT2,PDPK1,STK24,RAPGEF6,GAK,MTO1,PABPC1,RBKS,PANK3,FAS
TK,SMARCAD1,WNK1,DENND6B,PABPN1
CDK14,EIF2B4,PSMB10,XRN1,CKB,PTS,TNRC6A,EPHX2,RALGAPA2,
TARS,RAF1,NLRP1,PLCD1,SART1,RILPL1,MMS19,EEF2K,CUX1,CLNS
1A,NUP98,SMAD7,MCF2L,HDAC6,ARHGEF12,ATP6V1D,DYNC1I1,HG
S,NARS,LANCL2,DGKA,GLS,PSMB9,ARHGEF25,BCL2L11,STARD13,F
DPS,NISCH,CEP135,APITD1,NOL3,CAPZB,XAF1,PDLIM5,RHOF,PTPN
6,EEF1A1,VASP,CSNK2A1,UPF3A,NOD1,PRKACA,STAT2,ANAPC4,PL
K1,SDCCAG8,PNPO,PDE7B,PREPL,ASNS,ECHDC1,NUTF2,DNM1L,PT
GES2,UPF1,PPP5C,PDXK,RHOBTB1,RAB24,CAMK2D,PLCB4,ENGAS
cell
E,STK4,RARS,SIKE1,FGFR1,PAIP1,CAPRIN1,NADSYN1,PDE4D,TAB2,
ular
SHARPIN,CHKB,NADK,IDI1,RUSC2,SEC31A,MDM2,FKBP1A,PRKCH,P
_co
PM1F,FAM13A,PFDN5,SRP9,TNFRSF25,PLEKHG5,DDX58,RPL27,LCP
mpo
2,EIF4B,NUMA1,TPM4,RPL9,G3BP1,ADSL,CAPN10,CASP2,GALT,PRM
nent
T5,BLOC1S5,PAFAH1B1,GPCPD1,IL18,PDE8A,AACS,DDX6,BICD1,RG
S3,GARS,GRB10,MRPS7,PAN2,USP7,NRP1,RPL24,ARHGAP9,MTMR1
4,RPL37A,PTEN,FYN,IDH1,PHPT1,IKBKB,RQCD1,SNX17,KPNB1,SRG
AP2,PARN,MAPK8,MYLK,OSBPL3,DENND4C,CSK,CDK5RAP2,OAZ1,P
SMC6,IMPDH1,RNF146,DSN1,CDK6,AGBL5,NUP37,DDHD2,FARSA,PS
MC4,ARHGAP29,RANBP9,PHKG2,PARD6G,PAK1,NCK2,RHEB,CTSH,
ERC1,SMAD4,MEMO1,KLC1,DTYMK,EZR,RPL4,MTRR,CENPT,GOLPH
3,TANK,CDCA3,FLNA,IRF9,GLI3,MAPK12,RASGRF2,AK5,GAPDH,WW
1.36
605
702
9
1.
5
1
E
0
7
G
O:
00
36
09
4
small molecule binding
mol
ecul
ar_f
unct
ion
P1,ARHGEF7,NUP85,NUBP1,RGS2,STAM2,NCBP2,TGS1,DIABLO,EN
O4,FARP1,RAP1B,RPLP0,SNX27,TLN1,DOCK8,GSK3A,SNRPE,FPGS,
PCYT1A,CORO7,DPP7,DYNC1I2,MOB1A,PDCD4,PGM2,PSMA1,STAT
6,CARS2,ACIN1,CSNK1E,CACNB3,CLIC4,BNIP2,PHKG1,ATG3,SMAD9
,HBB,DUSP6,LIMS2,CD151,UCK1,EIF3I,VARS,LARS,PDPK1,KPNA1,ST
K24,PABPC1,CLASP1,PLA2G16,GORASP1,BCL2L2
CDK14,DHX34,ACADVL,EIF2B4,CKB,IGF1R,GK5,TNRC6A,MYO1D,SIR
T2,TRNAU1AP,TARS,RAF1,NLRP1,SEPT5,LEPRE1,CDK13,RBM6,ATP
2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,RBM17,SLC9B2,MC
F2L,ARHGEF12,VRK2,TYW1B,NARS,LANCL2,H6PD,DGKA,PNKP,ARH
GEF25,RGL4,RBPMS,STARD9,PAM,ABCC1,SNRNP70,HSD17B12,DD
X23,MARK4,UHMK1,RAB35,RANBP1,DDX39A,SKIV2L,MINK1,RHOF,E
EF1A1,ACTR3,CSNK2A1,UPF3A,NOD1,PRKACA,DHX9,PLK1,PNPO,A
SNS,DNM1L,UPF1,HDGF,FDXR,PDXK,NPC1,RHOBTB1,HERC2,CHD6,
SEPT4,EFTUD2,RAB24,CNP,GCDH,CAMK2D,DHRSX,GALK2,TNK2,ST
K4,MTG1,RARS,ALDH18A1,FGFR1,RAB18,NADSYN1,PMS1,ADCY4,C
ELF1,PDE4D,SGK1,PLEKHG4,CHKB,NADK,PRKCH,DAZAP1,IDH3G,IN
O80,RALGPS2,NAGK,PLEKHG5,DDX58,FAM114A2,MAGI1,NEK3,EIF4
B,RTKN,NPR1,RPS6KA5,G3BP1,RAB31,ALKBH3,NTPCR,HNRNPA3,U
BE2Q1,NOL8,GNAI1,DHRS1,MARK3,ISYNA1,SLFN11,STARD3,AACS,
STK38L,DDX6,NR1H3,GARS,CYTH2,PLK2,CHFR,PTGR2,FMO2,GMDS
,MAST2,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,IKBKB,ATP11B,PARN,ER
AL1,STK19,MAPK8,MYLK,DDX41,OSBPL3,RNF213,ABCA2,RAB8A,DE
NND4C,MAP4K4,CSK,ITPA,PSMC6,SWAP70,IMPDH1,SKIV2L2,CDK6,F
ARSA,PSMC4,HNRNPL,KIFC2,OGFOD3,UBA2,AAK1,PHKG2,PAK1,RA
B10,RHEB,HNRNPH3,TRPM7,CSF1R,DGKZ,ACTR2,HSD17B4,SRSF10
,GRPEL2,NAV1,DTYMK,MTRR,RBMS1,CLK3,RAB5A,BCS1L,ATP5A1,N
DUFV1,MAPK12,NDUFS2,RASGRF2,AK5,SIRT7,NOX4,ETFA,GAPDH,
NRBP2,STK36,SDHA,ATP8B2,ARHGEF7,CIRBP,UBA6,IDH3B,PTGR1,
NUBP1,NCBP2,PDGFRB,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RU
NX1,MKNK2,SMARCA4,DHX40,RAD54L2,KIF13B,CRCP,CLK4,ZNF638,
DOCK8,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO1E,D2HGDH,
1.31
473
047
1
3.
5
7
E
0
7
G
O:
00
71
84
0
cellular component organization or
biogenesis
PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP2,CARS2,ACIN1,PSD3,
CSNK1E,NTRK1,SHPRH,PHKG1,SIRT3,PLOD2,UCK1,VARS,LARS,DH
X37,SEPT2,PDPK1,STK24,RAPGEF6,GAK,MTO1,PABPC1,RBKS,PAN
K3,FASTK,SMARCAD1,WNK1,DENND6B,PABPN1
FZD6,CRBN,OBFC1,CADM1,PSMB10,CLMN,IGF1R,LAMB1,NPHP3,SIR
T2,NOC2L,RAF1,F11R,LEPRE1,COL9A1,SFSWAP,CDK13,BDNF,TAZ,
CPE,SART1,COL2A1,RAB34,SUPT5H,MARCH5,DPP4,BCL6,MMS19,S
HMT2,GPAA1,CLNS1A,NUP98,EED,SMAD7,HDAC6,ARHGEF12,EHMT
1,ATP6V1D,HGS,DERL2,CD72,TTLL3,ARPC4TTLL3,LEF1,GLS,PAX8,SUPT4H1,ITGA9,BCL2L11,STARD9,COG4,NIS
CH,PAM,CEP135,HSD17B12,DDX23,APITD1,MARK4,UHMK1,USP47,A
DAM8,CAPZB,PRPF40A,CD9,RANBP1,SIPA1L1,MINK1,PDLIM5,RHOF,
ACTR3,LHX4,VASP,CSNK2A1,NOD1,PRKACA,ANAPC4,PLK1,COL16A
1,TTC19,DNM1L,UPF1,RC3H1,PPP5C,CHD6,SEPT4,SLC11A2,ATG4B,
CNP,CLN8,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,JHDM1D,BBS1,TBC
1D14,TNK2,COL14A1,WAC,STK4,TRO,MTG1,FGFR1,HPS4,HSF4,DISP
biol
1,CAPRIN1,MMP16,CELF1,SNCAIP,SF3A2,TIMM23,PAF1,SGK1,SHAR
ogic
PIN,TCHP,RNF8,KIAA0586,SEC31A,MDM2,SNAP23,COL12A1,FKBP1A
al_p
,PRKCH,ANAPC16,PPM1F,YY1,TLN2,INO80,SSH2,CREB1,NPTN,RPL2
roce
7,PTPRK,SERPINH1,LIMCH1,MAGI1,NF1,PIH1D1,NEK3,ATG12,NUMA
ss
1,RGMB,COL18A1,RPL9,PHF15,NPR1,RPS6KA5,NIPBL,RAB31,ADSL,
BRD9,CAPN10,PKD2,LMNA,MITF,NOL8,RB1,PRMT5,LTBP4,MAPK8IP3
,GNAI1,USP3,BLOC1S5,TXNDC5,NEXN,RNF168,PAFAH1B1,PUM2,MT
CH1,TPP1,CHMP1A,NSA2,ARPC2,SYNE1,STK38L,DDX6,ADAM15,MU
M1,USP33,BICD1,NTMT1,LYSMD4,GCC2,NR1H3,CYTH2,PLK2,HEXA,
PLD6,FLCN,NRP1,CHFR,RPL24,IGFBP6,DAAM1,RPL37A,FAP,VPS72,
PTEN,FYN,SRPK1,FBXW7,PHPT1,SMARCD3,IFT172,SNX17,PXN,KPN
B1,SRGAP2,NCOR1,ATP11B,MEF2A,DYM,TNS1,FECH,ERAL1,SETD8,
WASH4P,TCTN1,SSBP1,CACNB1,VILL,MAPK8,MYCBP2,CLTCL1,MYL
K,N6AMT1,RAB8A,TRIM28,DENND4C,CSK,CDK5RAP2,COL9A3,ITPA,
PTPRC,TBCD,SKIV2L2,DSN1,ABI3BP,WDR61,TSPAN4,NUP37,COX14,
ZNF148,FLOT1,STAG2,AAK1,GOPC,RANBP9,WDR35,ATPAF2,PARD6
1.23
012
336
1
3.
7
3
E
0
7
G
O:
00
05
73
0
nucleolus
G,PAK1,NCK2,RAB10,SEMA6A,TCF4,ACD,TRPM7,HMGN2,SEMA4D,C
SF1R,ATP6V0A1,TIMM50,ACTR2,C3,P4HB,SRSF10,ROBO3,SS18,SM
AD4,GRPEL2,KLC1,C1QTNF3,NAV1,TGFB1I1,EZR,RPL4,CENPT,GOL
PH3,ING4,CDCA3,HPS3,FHOD1,FLNA,RAB5A,SUN2,MSL1,HGSNAT,B
CS1L,GLI3,TMED2,ENG,SIRT7,NOX4,EXT1,GAPDH,ERCC1,VTI1B,PH
F1,GAA,MTRF1L,SLC25A6,STK36,ARHGEF7,TBCE,ASAP1,UNC5B,CI
RBP,NUP85,NUBP1,NAA10,HAUS5,PTPRD,ITGA5,STAM2,NCBP2,PD
GFRB,COL8A1,TGS1,DZIP1,NCAPD3,CDK11A,CC2D2A,FARP1,SMAR
CA4,LMNB1,RPLP0,SDAD1,KIF13B,PTPN23,KCTD2,TLN1,GSK3A,SNR
PE,NLGN2,POLG,SETD2,TWF1,KANSL3,COL13A1,IGF2,FTSJ3,TROV
E2,MYO1E,ATXN3,CORO7,AMFR,MAU2,PHF21A,GPHN,CRIPAK,LON
P2,TANC1,ACIN1,ROBO2,SON,CACNB3,PMP22,KCTD17,CLIC4,BNIP2
,NTRK1,TFAM,SHPRH,ATG3,BRWD1,HBB,TGFBR3,TMEM237,LIMS2,
CD151,BAZ2A,PLOD2,RRP8,PHF19,LETM1,SEPT2,UQCRH,SENP6,PD
PK1,TSG101,FOXC1,KPNA1,ACAN,STK24,SSH1,FMOD,C2CD3,MTO1,
UBR5,EYA2,SMARCAD1,CLASP1,TENM4,GATA2,GORASP1
RNASEH2B,CRBN,OBFC1,EPHX2,UTRN,NOC2L,PPIL2,PPP1R13B,RS
C1A1,CBX5,SART1,CCDC91,RAB34,SUPT5H,RILPL1,BCL6,FUBP1,CM
PK2,ZFP91,CUX1,RBM17,FMR1,HDAC6,SYTL4,PNKP,PAX8,CPM,FDP
S,ABCC1,NOM1,DDX23,NOL3,POLR3E,PRPF40A,SUGP1,UPF3A,DHX
9,PDXK,ZC3H12A,SEPT4,SYMPK,EFTUD2,PCGF1,BCLAF1,JHDM1D,P
RPF3,MTG1,RARS,GTF3C1,SNCAIP,PAF1,DPF2,MDM2,SNAP23,DAZA
cell
P1,IDH3G,GMEB2,CREB1,FLII,ALDH6A1,ZEB1,NUMA1,RPL9,MED28,Z
ular
NF3,HNRNPA3,RSL1D1,NOL8,STX16,PAFAH1B1,RPS19BP1,CALCOC
_co
O2,SUB1,PWP2,NSA2,SYNE1,STK38L,ZNF263,NTMT1,SAP30BP,RUN
mpo
X2,IQGAP1,FBXW7,PARN,PRKRIP1,DDX41,MAN1A2,SRRM2,AFF4,DM
nent
TF1,PSMC6,RPF2,SKIV2L2,WDR61,ZNF148,WDR13,PSMC4,SP110,H
NRNPH3,ATP6V0A1,DGKZ,SMAD4,INO80E,EZR,RPL4,MTRR,ZNF44,A
UP1,ZNF687,CDC14B,CLK3,NR2C2,FIP1L1,DNTTIP2,MSL1,GLI3,ENG,
SIRT7,ERCC1,PRELID1,PHF12,REXO2,RGS2,HINFP,STAM2,NCBP2,R
UNX1,SDAD1,SNX27,ZNF638,DCAF17,KLHL7,NCOR2,PRPF4B,FTSJ3,
TROVE2,PDCD4,PSMA1,STAT6,ACIN1,SON,BTBD10,SPRED1,BRWD1
1.43
103
287
3
1.
6
7
E
0
6
G
O:
00
05
65
4
G
O:
00
16
78
7
nucleoplasm
hydrolase activity
,BAZ2A,RRP8,SEPT2,LUC7L3,SENP6,TSG101,FOXC1,ZC3H14,PHC2,
SMARCAD1,SYCP2L,ZC3H15,GATA2,PABPN1
PBX2,GTF3C2,PSMB10,NOC2L,CDK13,SIN3B,CBX5,SART1,SUPT5H,
SUPT20H,TBX2,MMS19,NUP98,EED,FMR1,SMAD7,HDAC6,ZNF496,LE
F1,PAX8,SUPT4H1,PSMB9,XBP1,SNRNP70,DDX23,METTL3,APITD1,P
OLR3E,PRPF40A,SUGP1,CSNK2A1,STAT2,ANAPC4,DHX9,PLK1,HDG
F,CCNL1,SYMPK,EFTUD2,DR1,CAMK2D,FYTTD1,PRPF3,GIT2,WAC,G
TF3C1,SF3A2,PAF1,MDM2,TBP,YY1,CREB1,RPRD1A,CCNL2,ZEB1,N
cell UMA1,MED28,PHF15,RPS6KA5,ALKBH3,HNRNPA3,RXRB,LMNA,RB1,
ular ZFPM2,TP53BP1,SENP2,RPS19BP1,SUB1,NR1H3,USP7,CHFR,PTEN,
_co RUNX2,CSTF1,FBXW7,INTS4,SMARCD3,KPNB1,NCOR1,MEF2A,PIAS
mpo 2,MAPK8,SRRM2,PBX3,TRIM28,PSMC6,WDR61,PRPF8,APPL2,PSMC
nent 4,HNRNPL,STAG2,ATPAF2,TCF4,ACD,WDR4,TIMM50,NFYC,SRSF10,
SMAD4,ING4,CDC14B,CLK3,NR2C2,FIP1L1,IRF9,MSL1,GLI3,MAPK12,
TCF12,ARNT,ERCC1,PHF1,PHF12,MED6,CIRBP,HINFP,NCBP2,TGS1,
RAD51B,FAM76B,BDP1,DBF4,MKNK2,LMNB1,NAA16,LRPPRC,ZNF63
8,SNRPE,NCOR2,KANSL3,ATXN3,MAU2,PHF21A,PSMA1,ACIN1,SON,
PNISR,SMAD9,DUSP6,ZBTB16,PHF19,LUC7L3,PDPK1,USF1,FOXC1,K
PNA1,ZC3H14,STK24,GATA2,PABPN1
USP10,CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,PSMB10,XRN1,MY
O1D,SIRT2,EPHX2,RALGAPA2,RAF1,NLRP1,SEPT5,DDI2,ATP2B1,CP
E,PLCD1,RAB34,ERCC6L2,DPP4,BCL6,PTPN22,GBP3,PLD1,VAPB,NL
N,GPAA1,SMPD4,MCF2L,USP4,HDAC6,ARHGEF12,ATP6V1D,DYNC1I
mol 1,RNH1,CASP4,H6PD,PNKP,LEF1,GLS,PSMB9,ARHGEF25,ADAMTS1,
ecul RGL4,BCL2L13,BCL2L11,STARD13,STARD9,XBP1,CPM,ABCC1,DDX2
ar_f 3,SCRN3,USP47,ADAM8,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
unct KRIT1,SKIV2L,MINK1,RHOF,PTPN6,EEF1A1,CSNK2A1,IGBP1,NOD1,P
ion
RKACA,RPP14,DHX9,PIGS,PDE7B,PREPL,ASNS,TBC1D2B,DNM1L,U
PF1,HDGF,PPP5C,HERC2,CHD6,ZC3H12A,TBC1D10B,SEPT4,SLC11A
2,EFTUD2,ATG4B,CNP,PIGN,PLCB4,DNPEP,TBC1D14,TNK2,ENGASE
,USP20,GIT2,MTG1,MAN2C1,FGFR1,RAB18,C2,CFB,MMP16,NADSYN
1,PMS1,ADCY4,PDE4D,RNASET2,PLEKHG4,IDI1,SEC31A,MDM2,RHB
1.42
463
886
2
3.
4
9
E
0
6
1.24
343
041
2
3.
5
0
E
0
6
DD1,FKBP1A,MTMR11,PPM1F,DIS3L,FAM13A,INO80,SSH2,CREB1,RA
LGPS2,PLEKHG5,DDX58,ZCCHC9,PTPRK,SNX13,RHBDF1,SERPINH1
,NF1,RTKN,G3BP1,RAB31,ALKBH3,CAPN10,NTPCR,CASP2,NEDD8MDP1,MDP1,LMNA,NUDT6,USP24,GNAI1,USP3,CPPED1,PAFAH1B1,
SENP2,EDEM2,GPCPD1,MTCH1,TPP1,SYTL2,DNALI1,CHMP1A,PDE8
A,DDX6,ACAP2,ANXA5,ADAM15,USP33,BICD1,RGS3,NR1H3,CYTH2,
PAN2,HEXA,USP7,PLD6,TENC1,ARHGAP9,MTMR14,FAP,PTEN,RNAS
EK,IQGAP1,C1R,PHPT1,PTP4A2,LGMN,HERPUD1,ADAMTS18,SRGAP
2,PTPRF,NCOR1,ATP11B,PPP1R10,MEF2A,PARN,SSBP1,MAPK8,US
P15,DDX41,MAN1A2,RNF213,ABCA2,DENND4C,MAP4K4,PTPRS,ITPA
,PTPRC,PSMC6,TBCD,SKIV2L2,AGBL5,DDHD2,ABHD16A,CPSF3L,PS
MC4,KIFC2,ARHGAP29,SGSM3,GOPC,PPA2,LEPR,RHEB,MTMR9,CT
SH,SEMA4D,GNB3,TIMM50,C3,GRPEL2,TBC1D22A,KLC1,NAV1,DDAH
1,USP54,CDC14B,DNHD1,RAB5A,BCS1L,C1S,ATP5A1,TMED2,RASGR
F2,GUSB,SIRT7,PCSK7,ERCC1,GAA,ATP8B2,ARHGEF7,PDIA5,ASAP1
,REXO2,NUBP1,PTPRD,RGS2,MAN2A2,PDGFRB,PTPN4,RAD51B,MA
N1B1,NIT1,DIABLO,MYO7B,FARP1,RAP1B,SMARCA4,USP40,YIF1A,D
HX40,RAD54L2,ACYP2,KIF13B,PTPN23,RHBDF2,TLN1,DOCK8,LONR
F3,GSK3A,NLGN2,POLG,ATG4A,PPAP2A,PDIA3,MYO1E,ATXN3,DPP7
,DYNC1I2,ERI3,RGL2,CHD2,LONP2,PSMA1,ACIN1,PSD3,CTBS,BNIP2,
NTRK1,SHPRH,SPRED1,TNFRSF10B,LMF1,DUSP6,ABHD4,STAMBPL
1,SIRT3,CPAMD8,SPCS3,PPT2,EGFL8,VARS,LARS,DHX37,CES2,SEN
P6,DDAH2,SSH1,RAPGEF6,MMP25,EYA2,SMARCAD1,WNK1,DENND6
B,PLA2G16
G
O:
00
05
91
2
adherens junction
cell
ular
_co
mpo
nent
LPP,EPHX2,SMAD7,VASP,TNK2,SIKE1,AFAP1,TLN2,FLII,PTPRK,NEX
N,ESAM,ARPC2,ADAM15,TENC1,PXN,TNS1,ITGB5,PTPRC,TBCD,PAK
1,TGFB1I1,EZR,VEZT,NOX4,ARHGEF7,ITGA5,TLN1,MYO1E,LIMS2,LU
C7L3,PDPK1,GAK
2.33
222
129
6
4.
2
1
E
0
6
G
O:
00
09
05
6
G
O:
00
catabolic process
regulation of protein metabolic process
USP10,RNASEH2B,CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,PSMB1
0,XRN1,GK5,MYO1D,SIRT2,EPHX2,RALGAPA2,SEPT5,ATP2B1,SPOP,
PLCD1,RAB34,SUPT5H,SUPT20H,UBXN1,BCL6,ENOSF1,GBP3,PLD1,
AMT,SMPD4,SMAD7,MCF2L,USP4,HDAC6,ARHGEF12,ATP6V1D,RNH
1,HGS,DERL2,H6PD,PNKP,GLS,PSMB9,ARHGEF25,RGL4,STARD13,A
BCC1,DDX23,RAD23A,USP47,ADAM8,DNAJC10,RAB35,RANBP1,SIPA
1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,CSNK2A1,UPF3A,P
RKACA,ANAPC4,DHX9,PLK1,PDE7B,TBC1D2B,DNM1L,UPF1,RC3H1,
NPC1,HERC2,CHD6,ZC3H12A,TBC1D10B,SEPT4,EFTUD2,RAB24,AT
G4B,CNP,CLN8,GCDH,PLCB4,TBC1D14,TNK2,USP20,GIT2,WAC,MTG
1,RAB18,PAIP1,PMS1,PDE4D,RNASET2,PLEKHG4,CPT1B,RNF8,MDM
2,RHBDD1,DIS3L,FAM13A,INO80,RALGPS2,NAGK,PLEKHG5,DDX58,A
biol LDH6A1,RPL27,SNX13,RHBDF1,NF1,ACAA1,EIF4B,NUB1,ATG12,RTK
ogic N,RPL9,G3BP1,RAB31,GALT,USP24,GNAI1,USP3,RNF168,PAFAH1B1,
al_p RNF217,TPP1,PDE8A,DDX6,ACAP2,USP33,LYSMD4,RGS3,CYTH2,PA
roce N2,HEXA,USP7,PLD6,CUL4A,CHFR,RPL24,ARHGAP9,RPL37A,PTEN,
ss
FYN,IQGAP1,FBXW7,HERPUD1,RQCD1,SNX17,KPNB1,SRGAP2,NCO
R1,ATP11B,OXCT1,PARN,USP15,DDX41,RNF213,ABCA2,DENND4C,M
AP4K4,ITPA,PSMC6,TBCD,RNF146,SKIV2L2,DDHD2,PSMC4,ARHGAP
29,SGSM3,GOPC,PHKG2,RHEB,CTSH,SEMA4D,GNB3,OS9,ALDH3B1,
HSD17B4,FUT4,SMAD4,GRPEL2,TBC1D22A,TGFB1I1,DDAH1,RPL4,U
SP54,DLST,FLNA,RAB5A,HGSNAT,ATP5A1,TMED2,THNSL2,RASGRF
2,GUSB,ARNT,GAPDH,ERCC1,GAA,NRBP2,WWP1,ATP8B2,ARHGEF7
,ASAP1,UBA6,RGS2,NCBP2,LPCAT1,VPS51,RAD51B,MAN1B1,ENO4,
FARP1,RAP1B,SMARCA4,USP40,RPLP0,DHX40,DOCK8,LONRF3,GSK
3A,ATG4A,MYO1E,ATXN3,ATG16L2,AMFR,PGM2,RGL2,CHD2,LONP2,
PSMA1,ACIN1,PSD3,CSNK1E,CTBS,BNIP2,NTRK1,PHKG1,ATG3,HBB,
ABHD4,DHX37,CES2,TSG101,KPNA1,DDAH2,ACAN,RAPGEF6,FMOD,
PABPC1,RBKS,UBR5,SMARCAD1,DENND6B,PLA2G16
biol ACADVL,EIF2B4,PSMB10,IGF1R,TNRC6A,TRNAU1AP,NOC2L,RAF1,U
ogic BXN1,ZFP91,CNTF,EEF2K,VAPB,FMR1,SMAD7,USP4,HDAC6,GLG1,H
al_p GS,PSMB9,RBPMS,XBP1,RAD23A,APITD1,UHMK1,ADAM8,DNAJC10,
1.28
382
148
7
4.
9
0
E
0
6
1.39
918
260
5.
2
8
51
24
6
G
O:
00
30
05
5
G
O:
00
32
99
1
roce PTPN6,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,ANAPC4,PLK1,ASNS,
ss
UPF1,HDGF,CCNL1,SEPT4,SYMPK,FAM58A,CLN8,GIGYF2,TNK2,WA
C,STK4,ZNF540,FGFR1,C2,CFB,PAIP1,CAPRIN1,ADCY4,CELF1,TAB2,
RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,PPM1F,NPTN,SRP9,CCNL2,R
HBDF1,SERPINH1,NF1,EIF4B,NUB1,RPS6KA5,NIPBL,PKD2,LMNA,RB
1,LTBP4,MAPK8IP3,RNF168,SENP2,PUM2,TPP1,SH3BP5,RGS3,NR1H
3,FLCN,NRP1,CUL4A,MAST2,PTEN,FYN,IQGAP1,FBXW7,HERPUD1,P
XN,NCOR1,FECH,PRKRIP1,NECAB3,MAPK8,CSK,PTPRC,PSMC6,WD
R61,PSMC4,SGSM3,PAK1,NCK2,SEMA4D,CSF1R,C3,PIWIL4,SMAD4,
CD276,CDC14B,FLNA,AK5,ENG,ARNT,NOX4,GAPDH,PHF1,PDIA5,MD
FI,CIRBP,ITGA5,RGS2,NCBP2,LPCAT1,PDGFRB,CARD14,TNFRSF14,
MKNK2,YIF1A,TLN1,GSK3A,TWF1,IGF2,PSTK,PDCD4,CRIPAK,PSMA1
,CSNK1E,CDK5RAP1,NTRK1,SPRED1,TNFRSF10B,DUSP6,VARS,LAR
S,PHF19,PKD1,PDPK1,SSH1,CDK5RAP3,C2CD3,PABPC1,UBR5,WNK
1,GATA2
cell-substrate junction
cell
ular LPP,EPHX2,ACTR3,VASP,SIKE1,AFAP1,TLN2,FLII,NEXN,ARPC2,TEN
_co C1,PXN,TNS1,ITGB5,PTPRC,PAK1,TGFB1I1,EZR,NOX4,ARHGEF7,ITG
mpo A5,TLN1,LIMS2,LUC7L3,PDPK1,GAK
nent
macromolecular complex
CDK14,RNASEH2B,CRBN,OBFC1,PBX2,EIF2B4,GTF3C2,PSMB10,XR
N1,LAMB1,TNRC6A,MYO1D,SIRT2,UTRN,PPIL2,NLRP1,SEPT5,GAS8,
CDK13,SPOP,CBX5,SART1,SUPT5H,SUPT20H,HLAcell
DPB1,UBXN1,TBX2,MMS19,CNTF,GPAA1,RBM17,NUP98,EED,FMR1,S
ular
MAD7,HDAC6,ATP6V1D,DYNC1I1,RNH1,TTLL3,ARPC4_co
TTLL3,LEF1,HLAmpo
C,SUPT4H1,PSMB9,ITGA9,BCL2L11,STARD9,COG4,SNRNP70,DDX23
nent
,HLADQA1,RAD23A,AP3S2,APITD1,UHMK1,USP47,ADAM8,MAP7D1,CAPZ
B,DNAJC10,PCGF6,KRIT1,SKIV2L,PTPN6,SUGP1,EEF1A1,ACTR3,CS
4
E
0
6
2.56
215
860
6
7.
7
1
E
0
6
1.21
846
194
8.
1
2
E
0
6
NK2A1,UPF3A,PRKACA,ANAPC4,DHX9,PIGS,PLK1,NUTF2,DNM1L,TX
NL1,UPF1,HDGF,RC3H1,NUP210,SEPT4,MIB2,SLC11A2,EFTUD2,IL13
RA1,CNP,PCGF1,VAMP7,DR1,CAMK2D,HLADMB,BBS1,PRPF3,TNK2,FLG,DCAF11,WAC,RARS,COPS7B,VTI1A,CA
PRIN1,GTF3C1,PMS1,CELF1,SF3A2,TIMM23,PAF1,SHARPIN,TCHP,R
NF8,SEC31A,MDM2,ANAPC16,PPM1F,TBP,DIS3L,YY1,INO80,PFDN5,
CREB1,SRP9,RPRD1A,RPL27,AP4B1,ZEB1,PIH1D1,EIF4B,EMC3,ATG
12,NUMA1,TPM4,RPL9,MED28,PHF15,RPS6KA5,G3BP1,NIPBL,DCAF8
,PKD2,STRN4,HNRNPA3,LMNA,RSL1D1,MITF,ITGA3,RB1,PRMT5,GN
AI1,PLEKHA2,STX16,TP53BP1,BLOC1S5,RNF168,PAFAH1B1,SENP2,
PUM2,DNALI1,SUB1,NSA2,ARPC2,SYNE1,EPN2,DDX6,USP33,BICD1,
MRPS7,PAN2,NRP1,CUL4A,RPL24,RPL37A,VPS72,RUNX2,IQGAP1,F
BXW7,INTS4,SMARCD3,IKBKB,RQCD1,PXN,KPNB1,NCOR1,PPP1R10
,SMEK1,WASH4P,ITGB5,TCTN1,CACNB1,CLTCL1,DDX41,SRRM2,PB
X3,HLAF,N6AMT1,ABCA2,DENND4C,CDK5RAP2,PSMC6,TBCD,EMC4,SKIV2L
2,DSN1,CDK6,WDR61,NUP37,PRPF8,APPL2,CLTB,FLOT1,PSMC4,HN
RNPL,KIFC2,GOPC,RANBP9,WDR35,PHKG2,PARD6G,PAK1,RAB10,R
HEB,HNRNPH3,ZSWIM7,TCF4,ACD,CSF1R,ATP6V0A1,ERC1,TIMM50,
OS9,ACTR2,NFYC,PIWIL4,TMED3,SS18,SMAD4,FNTB,CHURC1FNTB,KLC1,NAV1,INO80E,EZR,RPL4,CENPT,ING4,EIF3M,DNHD1,FIP
1L1,DLST,MRPL49,FLNA,SUN2,MSL1,BCS1L,ACTR10,ATP5A1,GLI3,N
DUFV1,DCAF6,NDUFS2,THOC2,VEZT,ENG,SCFD1,SIRT7,TCF12,ARN
T,NOX4,GAPDH,ERCC1,PHF1,SLC25A6,SDHA,WWP1,ARHGEF7,PHF
12,TBCE,NAT9,VAMP4,MED6,CIRBP,NUP85,HAUS5,ITGA5,CLIP2,NCB
P2,VPS51,TGS1,DZIP1,NCAPD3,ELP6,CC2D2A,DIABLO,ENO4,MYO7B
,RAP1B,CANX,SMARCA4,LMNB1,NAA16,LRPPRC,RPLP0,KIF13B,CRC
P,DCAF17,KLHL7,PHC3,DNAJC21,GSK3A,SNRPE,ITGA11,POLG,MRP
L3,NCOR2,KANSL3,PRPF4B,NARF,TROVE2,MYO1E,DYNC1I2,MAU2,
PHF21A,PSMA1,CSNK1E,CACNB3,CLIC4,NSMCE4A,BNIP2,SHPRH,P
HKG1,CACNA2D1,ATG3,SMAD9,HBB,TGFBR3,ZBTB16,BAZ2A,SPCS3
,EIF3I,RRP8,PHF19,SEPT2,UQCRH,PKD1,USF1,FOXC1,KPNA1,PABP
C1,PHC2,CLASP1,GATA2,PABPN1
G
O:
00
05
92
4
G
O:
00
32
26
8
G
O:
00
05
59
3
cell-substrate adherens junction
cell
ular LPP,EPHX2,VASP,SIKE1,AFAP1,TLN2,FLII,NEXN,ARPC2,TENC1,PXN,
_co TNS1,ITGB5,PTPRC,PAK1,TGFB1I1,EZR,NOX4,ARHGEF7,ITGA5,TLN
mpo 1,LIMS2,LUC7L3,PDPK1,GAK
nent
regulation of cellular protein metabolic
process
ACADVL,EIF2B4,PSMB10,IGF1R,TNRC6A,TRNAU1AP,NOC2L,RAF1,U
BXN1,ZFP91,CNTF,EEF2K,VAPB,FMR1,SMAD7,USP4,HDAC6,PSMB9,
RBPMS,XBP1,RAD23A,APITD1,UHMK1,ADAM8,DNAJC10,PTPN6,IGB
P1,UPF3A,NOD1,PRKACA,ANAPC4,PLK1,ASNS,UPF1,HDGF,CCNL1,S
EPT4,SYMPK,FAM58A,CLN8,GIGYF2,TNK2,WAC,STK4,ZNF540,FGFR
1,PAIP1,CAPRIN1,ADCY4,CELF1,TAB2,RNF8,SEC31A,MDM2,FKBP1A,
biol
PPM1F,NPTN,SRP9,CCNL2,RHBDF1,NF1,EIF4B,NUB1,RPS6KA5,NIPB
ogic
L,PKD2,LMNA,RB1,MAPK8IP3,RNF168,SENP2,PUM2,TPP1,SH3BP5,R
al_p
GS3,NR1H3,FLCN,NRP1,PTEN,IQGAP1,FBXW7,HERPUD1,PXN,NCOR
roce
1,FECH,PRKRIP1,MAPK8,CSK,PTPRC,PSMC6,WDR61,PSMC4,PAK1,
ss
NCK2,SEMA4D,CSF1R,C3,PIWIL4,SMAD4,CDC14B,AK5,ENG,ARNT,N
OX4,GAPDH,PHF1,PDIA5,MDFI,CIRBP,ITGA5,RGS2,NCBP2,PDGFRB,
CARD14,TNFRSF14,MKNK2,YIF1A,TLN1,GSK3A,TWF1,IGF2,PSTK,PD
CD4,CRIPAK,PSMA1,CSNK1E,CDK5RAP1,NTRK1,SPRED1,TNFRSF10
B,DUSP6,VARS,LARS,PHF19,PKD1,PDPK1,SSH1,CDK5RAP3,PABPC1
,UBR5,WNK1,GATA2
FACIT collagen
cell
ular
_co COL9A1,COL16A1,COL14A1,COL12A1,COL9A3
mpo
nent
2.61
069
548
8.
1
5
E
0
6
1.42
027
751
6
8.
2
9
E
0
6
11.6
611
064
8
1.
0
4
E
0
5
G
O:
00
44
24
8
G
O:
00
06
13
cellular catabolic process
nucleobase-containing compound metabolic
process
USP10,RNASEH2B,CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,PSMB1
0,XRN1,MYO1D,SIRT2,EPHX2,RALGAPA2,SEPT5,ATP2B1,SPOP,RAB
34,SUPT5H,SUPT20H,UBXN1,BCL6,ENOSF1,GBP3,AMT,SMPD4,SMA
D7,MCF2L,USP4,HDAC6,ARHGEF12,ATP6V1D,RNH1,DERL2,PNKP,G
LS,PSMB9,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,RAD23A,USP4
7,ADAM8,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,
MINK1,RHOF,EEF1A1,UPF3A,PRKACA,ANAPC4,DHX9,PLK1,PDE7B,T
BC1D2B,DNM1L,UPF1,RC3H1,NPC1,HERC2,CHD6,ZC3H12A,TBC1D1
0B,SEPT4,EFTUD2,RAB24,ATG4B,CNP,CLN8,GCDH,TBC1D14,TNK2,
USP20,GIT2,WAC,MTG1,RAB18,PAIP1,PMS1,PDE4D,RNASET2,PLEK
HG4,CPT1B,RNF8,MDM2,RHBDD1,DIS3L,FAM13A,INO80,RALGPS2,N
biol AGK,PLEKHG5,DDX58,ALDH6A1,RPL27,SNX13,RHBDF1,NF1,ACAA1,
ogic EIF4B,NUB1,ATG12,RTKN,RPL9,G3BP1,RAB31,GALT,USP24,GNAI1,U
al_p SP3,RNF168,PAFAH1B1,RNF217,TPP1,PDE8A,DDX6,ACAP2,USP33,L
roce YSMD4,RGS3,CYTH2,PAN2,HEXA,USP7,CUL4A,CHFR,RPL24,ARHGA
ss
P9,RPL37A,PTEN,IQGAP1,FBXW7,HERPUD1,RQCD1,KPNB1,SRGAP2
,NCOR1,ATP11B,OXCT1,PARN,USP15,DDX41,RNF213,ABCA2,DENN
D4C,MAP4K4,ITPA,PSMC6,TBCD,RNF146,SKIV2L2,PSMC4,ARHGAP2
9,SGSM3,GOPC,PHKG2,RHEB,CTSH,SEMA4D,GNB3,OS9,ALDH3B1,H
SD17B4,GRPEL2,TBC1D22A,TGFB1I1,DDAH1,RPL4,USP54,DLST,RAB
5A,ATP5A1,TMED2,THNSL2,RASGRF2,ARNT,ERCC1,NRBP2,WWP1,A
TP8B2,ARHGEF7,ASAP1,UBA6,RGS2,NCBP2,VPS51,RAD51B,MAN1B
1,FARP1,RAP1B,SMARCA4,USP40,RPLP0,DHX40,DOCK8,LONRF3,G
SK3A,ATG4A,MYO1E,ATXN3,ATG16L2,AMFR,RGL2,CHD2,LONP2,PS
MA1,ACIN1,PSD3,CSNK1E,BNIP2,NTRK1,ATG3,HBB,DHX37,TSG101,
KPNA1,DDAH2,ACAN,RAPGEF6,FMOD,PABPC1,UBR5,SMARCAD1,D
ENND6B
biol FZD6,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX34,KAN
ogic K2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,IGF1R,MYO1D,SIRT
al_p 2,RALGAPA2,MYNN,NOC2L,TARS,RAF1,ZNF131,SEPT5,RSC1A1,SFS
roce WAP,CDK13,RBM6,SIN3B,ATP2B1,CBX5,SART1,RAB34,SUPT5H,SUP
ss
T20H,PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,GBP3,VAPB,
1.29
274
321
1.
1
2
E
0
5
1.15
350
967
2
1.
1
8
E
-
9
CUX1,RBM17,CLNS1A,NUP98,EED,SMAD7,MCF2L,PPFIBP2,HDAC6,A
RHGEF12,EHMT1,ATP6V1D,RNH1,ZNF496,TYW1B,NARS,LANCL2,H6
PD,PNKP,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,RGL
4,RBPMS,STARD13,ZSCAN31,XBP1,PAM,ABCC1,NOM1,SNRNP70,DD
X23,RAD23A,METTL3,APITD1,USP47,ADAM8,NOL3,POLR3E,GABPB1,
PRPF40A,DNAJC10,RAB35,PCGF6,RANBP1,SIPA1L1,DDX39A,KRIT1,
SKIV2L,MINK1,RHOF,SUGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,
NOD1,STAT2,RPP14,DHX9,PLK1,ZNF446,PDE7B,ASNS,TBC1D2B,DN
M1L,PTGES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,PPP5C,CCNL1,HER
C2,CHD6,ZC3H12A,TBC1D10B,SEPT4,POLM,SYMPK,EFTUD2,FAM58
A,CNP,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,Z
NF710,TBC1D14,PRPF3,TNK2,GIT2,WAC,ZNF142,FUBP3,MTG1,RARS
,ZNF540,FGFR1,RAB18,HSF4,PAIP1,GTF3C1,ERH,NADSYN1,PMS1,A
DCY4,CELF1,PDE4D,RNASET2,SF3A2,PAF1,TAB2,SGK1,PLEKHG4,D
PF2,NADK,RNF8,SEC31A,MDM2,ZFYVE26,PRKCH,PPM1F,ZNF595,TB
P,DIS3L,YY1,FAM13A,INO80,GMEB2,PFDN5,CREB1,RALGPS2,FLII,PL
EKHG5,RPRD1A,DDX58,ALDH6A1,RPL27,CCNL2,PTPRK,SNX13,NF1,
ZEB1,EIF4B,IFITM3,ASCC2,RGMB,RTKN,EBF1,RPL9,MED28,NPR1,ZN
F3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,BRD9,ZNF837,PKD
2,HNRNPA3,RXRB,GALT,LMNA,MITF,NOL8,RB1,PRMT5,GNAI1,USP3,
MZF1,ZFPM2,TP53BP1,RNF168,PAFAH1B1,ZNF865,SENP2,TPP1,SUB
1,CHMP1A,PDE8A,NSA2,DDX6,ACAP2,ZNF558,MUM1,ZNF263,ZNF18
0,BICD1,ZNF276,RGS3,NR1H3,GARS,CYTH2,PAN2,USP7,PLD6,FLCN,
CUL4A,ZNF605,ZNF410,FMO2,GMDS,RPL24,ARHGAP9,RPL37A,SAP3
0BP,VPS72,PTEN,IDH1,SRPK1,RNASEK,RUNX2,CSTF1,IQGAP1,FBX
W7,INTS4,SMARCD3,HERPUD1,IKBKB,CTNS,RQCD1,KPNB1,SRGAP
2,RFX7,NCOR1,ATP11B,PPP1R10,MEF2A,PARN,SETD8,PIAS2,SSBP1
,MAPK8,MYCBP2,USP15,DDX41,SRRM2,PBX3,RNF213,ZNF565,ABCA
2,AFF4,TRIM28,DENND4C,DMTF1,MAP4K4,CDK5RAP2,ITPA,PTPRC,
PSMC6,SWAP70,TBCD,IMPDH1,UBP1,SKIV2L2,WDR61,EBF4,PRPF8,
FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,ARHGAP29,SGSM3,STAG2,S
P110,GOPC,PPA2,NCK2,RHEB,HNRNPH3,ZSWIM7,TCF4,ACD,IKZF5,
0
5
HMGN2,WDR4,SEMA4D,GNB3,SSBP2,ERC1,NFYC,PIWIL4,RPUSD4,S
RSF10,SS18,RCOR3,SMAD4,GRPEL2,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF4
4,CREBZF,ING4,RBMS1,ZNF687,CDC14B,CLK3,SLC23A2,NR2C2,FHO
D1,FIP1L1,DNTTIP2,FLNA,RAB5A,IRF9,ATP5A1,GLI3,TMED2,MAPK12,
CCDC59,DCAF6,RASGRF2,AK5,THOC2,ENG,SIRT7,ZSCAN5A,TCF12,
ARNT,NOX4,ZNF692,ERCC1,PHF1,STK36,WWP1,ATP8B2,ARHGEF7,
PHF12,PDIA5,ASAP1,REXO2,MED6,MDFI,ZNF554,IDH3B,NAA10,CIZ1,
RGS2,HINFP,NCBP2,MLX,PDGFRB,TGS1,NCAPD3,RAD51B,CDK11A,
GLIS3,ELP6,BDP1,FARP1,DBF4,RAP1B,RUNX1,SMARCA4,NAA16,LR
PPRC,YIF1A,RPLP0,DHX40,RAD54L2,CLASRP,ZNF518B,CRCP,CLK4,
ZNF90,ZNF638,PER3,TLN1,DOCK8,CHTF8,LONRF3,GSK3A,SNRPE,P
OLG,ZNF383,POLR2J3,NCOR2,FPGS,SETD2,PRPF4B,IGF2,PTGIS,FT
SJ3,TROVE2,MYO1E,ATXN3,PSTK,PHF21A,PDCD4,SOX13,ERI3,RGL
2,CHD2,LONP2,PSMA1,STAT6,CARS2,ACIN1,PSD3,CSNK1E,SON,ZN
F138,ZNF705A,CDK5RAP1,NSMCE4A,BNIP2,NTRK1,TFAM,SHPRH,BR
WD1,SMAD9,TGFBR3,ZFC3H1,ZBTB16,BAZ2A,UCK1,RRP8,VARS,LA
RS,PHF19,LMCD1,DHX37,LUC7L3,PKD1,PDPK1,TSG101,USF1,FOXC
1,ARL6IP4,KPNA1,HEMK1,CDK5RAP3,RAPGEF6
G
O:
00
05
92
5
G
O:
19
01
57
5
focal adhesion
cell
ular LPP,EPHX2,VASP,SIKE1,AFAP1,TLN2,FLII,ARPC2,TENC1,PXN,TNS1,I
_co TGB5,PTPRC,PAK1,TGFB1I1,EZR,NOX4,ARHGEF7,ITGA5,TLN1,LIMS
mpo 2,LUC7L3,PDPK1,GAK
nent
2.60
340
981
8
organic substance catabolic process
biol
ogic
al_p
roce
ss
USP10,RNASEH2B,CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,PSMB1
0,XRN1,GK5,MYO1D,SIRT2,EPHX2,RALGAPA2,SEPT5,ATP2B1,SPOP,
PLCD1,RAB34,UBXN1,BCL6,ENOSF1,GBP3,PLD1,AMT,SMPD4,SMAD
7,MCF2L,USP4,HDAC6,ARHGEF12,ATP6V1D,RNH1,HGS,DERL2,H6P
D,PNKP,GLS,PSMB9,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,RAD
23A,USP47,ADAM8,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,KRIT
1.27
958
283
5
1.
2
9
E
0
5
1.
3
0
E
0
G
O:
00
43
16
8
anion binding
mol
ecul
ar_f
unct
ion
1,SKIV2L,MINK1,RHOF,EEF1A1,CSNK2A1,UPF3A,PRKACA,ANAPC4,D
HX9,PLK1,PDE7B,TBC1D2B,DNM1L,UPF1,RC3H1,HERC2,CHD6,TBC1
D10B,SEPT4,EFTUD2,CNP,CLN8,GCDH,PLCB4,TBC1D14,TNK2,USP2
0,GIT2,WAC,MTG1,RAB18,PAIP1,PMS1,PDE4D,RNASET2,PLEKHG4,C
PT1B,RNF8,MDM2,RHBDD1,DIS3L,FAM13A,INO80,RALGPS2,NAGK,P
LEKHG5,DDX58,ALDH6A1,RPL27,SNX13,RHBDF1,NF1,ACAA1,EIF4B,
NUB1,RTKN,RPL9,G3BP1,RAB31,GALT,USP24,GNAI1,USP3,RNF168,
PAFAH1B1,RNF217,TPP1,PDE8A,DDX6,ACAP2,USP33,RGS3,CYTH2,
PAN2,HEXA,USP7,PLD6,CUL4A,CHFR,RPL24,ARHGAP9,RPL37A,PTE
N,FYN,IQGAP1,FBXW7,HERPUD1,RQCD1,SNX17,KPNB1,SRGAP2,NC
OR1,ATP11B,OXCT1,PARN,USP15,DDX41,RNF213,ABCA2,DENND4C,
MAP4K4,ITPA,PSMC6,TBCD,RNF146,SKIV2L2,DDHD2,PSMC4,ARHGA
P29,SGSM3,GOPC,PHKG2,RHEB,CTSH,SEMA4D,GNB3,OS9,ALDH3B
1,HSD17B4,FUT4,SMAD4,GRPEL2,TBC1D22A,TGFB1I1,DDAH1,RPL4,
USP54,DLST,FLNA,RAB5A,HGSNAT,ATP5A1,TMED2,THNSL2,RASGR
F2,GUSB,ARNT,GAPDH,ERCC1,GAA,WWP1,ATP8B2,ARHGEF7,ASAP
1,UBA6,RGS2,NCBP2,LPCAT1,RAD51B,MAN1B1,ENO4,FARP1,RAP1B
,SMARCA4,USP40,RPLP0,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,AT
XN3,AMFR,PGM2,RGL2,CHD2,LONP2,PSMA1,ACIN1,PSD3,CSNK1E,C
TBS,BNIP2,NTRK1,PHKG1,ABHD4,DHX37,TSG101,KPNA1,DDAH2,AC
AN,RAPGEF6,FMOD,PABPC1,RBKS,UBR5,SMARCAD1,DENND6B,PL
A2G16
CDK14,PLEKHA3,DHX34,ACADVL,EIF2B4,CKB,IGF1R,GK5,MYO1D,SI
RT2,TARS,RAF1,NLRP1,SEPT5,LEPRE1,CDK13,ATP2B1,RAB34,ERC
C6L2,CMPK2,GBP3,SHMT2,EEF2K,PGS1,MCF2L,ARHGEF12,VRK2,TY
W1B,NARS,LANCL2,DGKA,PNKP,ARHGEF25,ADAMTS1,RGL4,STARD
9,PAM,ABCC1,HSD17B12,DDX23,MARK4,UHMK1,RAB35,RANBP1,DD
X39A,SKIV2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,
DHX9,PLK1,PNPO,ASNS,DNM1L,UPF1,HDGF,FDXR,PDXK,RHOBTB1,
HERC2,CHD6,SEPT4,EFTUD2,AAMP,RAB24,GCDH,CAMK2D,GALK2,T
NK2,STK4,MTG1,RARS,ALDH18A1,FGFR1,RAB18,NADSYN1,PMS1,A
DCY4,PDE4D,SGK1,PLEKHG4,CHKB,NADK,PRKCH,IDH3G,INO80,TH
5
1.27
681
117
6
1.
4
1
E
0
5
G
O:
00
15
63
0
G
O:
00
31
microtubule cytoskeleton
organelle membrane
BS3,RALGPS2,NAGK,PLEKHG5,DDX58,ALDH6A1,MAGI1,NEK3,RTKN,
NPR1,RPS6KA5,G3BP1,RAB31,ALKBH3,NTPCR,UBE2Q1,GNAI1,PLEK
HA2,MARK3,PAFAH1B1,SLFN11,ACBD4,SYTL2,AACS,STK38L,DDX6,
GARS,CYTH2,PLK2,NRP1,FMO2,GMDS,MAST2,FYN,ALDH1A3,SRPK1
,RUNX2,IKBKB,PTPRF,ATP11B,ERAL1,STK19,MAPK8,MYLK,DDX41,R
NF213,ABCA2,RAB8A,DENND4C,MAP4K4,CSK,PTPRC,PSMC6,SWAP
70,SKIV2L2,CDK6,ABI3BP,FARSA,PSMC4,KIFC2,OGFOD3,UBA2,AAK
1,PHKG2,PAK1,RAB10,RHEB,TRPM7,CSF1R,DGKZ,ACTR2,DDAH1,DT
YMK,MTRR,CLK3,LRPAP1,RAB5A,BCS1L,ATP5A1,THNSL2,NDUFV1,
MAPK12,RASGRF2,AK5,SIRT7,NOX4,ETFA,NRBP2,STK36,SDHA,ATP
8B2,ARHGEF7,UBA6,NUBP1,PDGFRB,RAD51B,CDK11A,MYO7B,FAR
P1,RAP1B,RUNX1,MKNK2,SMARCA4,DHX40,RAD54L2,KIF13B,CLK4,F
GF14,DOCK8,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,COL13A1,W
DFY3,MYO1E,D2HGDH,PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP
2,CARS2,PSD3,CSNK1E,NTRK1,SHPRH,PHKG1,TGFBR3,SIRT3,PLOD
2,UCK1,VARS,LARS,DHX37,SEPT2,PDPK1,DDAH2,STK24,RAPGEF6,
GAK,MTO1,RBKS,PANK3,FASTK,SMARCAD1,WNK1,DENND6B
SIRT2,GAS8,MMS19,SHMT2,HDAC6,DYNC1I1,SYTL4,TTLL3,BCL2L11,
STARD9,CEP135,MARK4,MAP7D1,RANBP1,PRKACA,DHX9,PLK1,SDC
CAG8,NUTF2,TTC19,DNM1L,HERC2,CNP,CCDC14,PDE4D,DPF2,TCH
cell P,KIAA0586,ZFYVE26,DIS3L,INO80,FLII,NUMA1,PKD2,PPP2R3C,RB1,
ular GNAI1,PAFAH1B1,DNALI1,CHMP1A,ZNF263,BICD1,PLK2,MAST2,IQG
_co AP1,CEP112,PXN,NCOR1,SMEK1,TCTN1,MYCBP2,CLTCL1,ABCA2,R
mpo AB8A,CSK,CDK5RAP2,TBCD,DDHD2,FLOT1,KIFC2,RANBP9,WDR35,E
nent VC,SS18,SMAD4,FNTB,KLC1,NAV1,EZR,ZNF44,DNHD1,ACTR10,AK5,
GAPDH,PHF1,TBCE,NUP85,HAUS5,CLIP2,DZIP1,CC2D2A,LRPPRC,YI
F1A,KIF13B,PTPN23,TLN1,TTLL11,DYNC1I2,NUCB1,PSMA1,CLIC4,BN
IP2,SEPT2,THAP6,C2CD3,CLASP1,CC2D1A
cell SLC25A37,ACADVL,RAF1,SLC16A3,TAZ,CPE,RAB34,HLAular DPB1,ST3GAL1,MARCH5,UBXN1,SHMT2,PLD1,VAPB,GPAA1,CUX1,P
_co GS1,NUP98,SLC9B2,SMPD4,GLG1,ATP6V1D,VRK2,HGS,DERL2,IL15R
mpo A,SYTL4,HLA-
1.53
200
089
6
1.
4
3
E
0
5
1.29
525
017
4
1.
4
7
E
09
0
G
O:
00
46
48
3
nent
heterocycle metabolic process
C,BCL2L13,BCL2L11,XYLT1,STARD13,COG4,PAM,HSD17B12,HLADQA1,AP3S2,MPDU1,ADAM8,CD9,MARCH6,RNF24,ACTR3,PIGS,VPS
52,LMAN2,TTC19,DNM1L,PTGES2,FDXR,PIGG,NPC1,SHISA5,HERC2,
NUP210,SLC11A2,CNP,CLN8,PIGN,GCDH,VAMP7,CAMK2D,HLADMB,BBS1,TNK2,ALDH18A1,TPCN2,VTI1A,TIMM23,TAB2,SGK1,CPT1
B,CYP2R1,SEC31A,MDM2,RHBDD1,FKBP1A,GPAT2,MCFD2,TTC1,SR
P9,QSOX1,SNX13,RHBDF1,SNX21,IFITM3,EMC3,RAB31,ALG6,ST3GA
L4,GCNT2,PKD2,GOLGA8B,GOLGA8A,MAPK8IP3,STX16,DHRS1,PAF
AH1B1,SENP2,EDEM2,MTCH1,STARD3,CHMP1A,SYNE1,EPN2,GALN
T2,PLD6,FMO2,UST,HERPUD1,CTNS,SNX17,KPNB1,SRGAP2,ATP11B
,FECH,ERAL1,COX7A2L,WASH4P,TMEM189,NECAB3,CLSTN2,CLTCL
1,MAN1A2,OSBPL3,HLAF,ABCA2,RAB8A,SLC35D2,DENND4C,TMEM66,STX18,EMC4,COX14,A
PPL2,CLTB,GOPC,ST6GALNAC5,PAK1,EVC,NCK2,LEPROT,RAB10,V
PS45,ATP6V0A1,ERC1,TIMM50,OS9,HSD17B4,ELOVL1,FUT4,TMED3,
GRPEL2,SLC35A4,SLC39A7,MBOAT2,AUP1,GOLPH3,CDC14B,RAB5A
,SUN2,HGSNAT,MGAT5,BCS1L,ATP5A1,TMED2,NDUFV1,NDUFS2,RA
SGRF2,MCOLN1,B4GALT4,SCFD1,PCSK7,NOX4,EXT1,GAA,B3GAT3,
SLC25A6,SDHA,PDIA5,VAMP4,NUP85,STAM2,MAN2A2,LPCAT1,EBPL
,MAN1B1,LETMD1,CANX,LMNB1,LRPPRC,YIF1A,RHBDF2,CD164,PAP
PAAS1,POLG,FPGS,SFXN3,PCYT1A,PIGO,PTGIS,ATXN3,CORO7,AMFR,
SLC25A24,CLIC4,NTRK1,LMF1,SEC31B,SLC25A46,ZDHHC8,PLOD2,S
PCS3,LETM1,SEPT2,UQCRH,CCZ1B,TSG101,SLC9A8,CD63,SCAMP1,
ALG9,GORASP1,BCL2L2
FZD6,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX34,KAN
biol K2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,IGF1R,PTS,MYO1D,
ogic SIRT2,RALGAPA2,MYNN,NOC2L,TARS,RAF1,ZNF131,SEPT5,RSC1A1
al_p ,SFSWAP,CDK13,RBM6,SIN3B,ATP2B1,CBX5,SART1,RAB34,SUPT5H,
roce SUPT20H,PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,GBP3,SH
ss
MT2,VAPB,CUX1,RBM17,CLNS1A,NUP98,EED,SMAD7,MCF2L,PPFIBP
2,HDAC6,ARHGEF12,EHMT1,ATP6V1D,RNH1,ZNF496,TYW1B,NARS,L
0
5
1.14
744
887
6
1.
6
9
E
0
5
ANCL2,H6PD,PNKP,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,ARHG
EF25,RGL4,RBPMS,STARD13,ZSCAN31,XBP1,PAM,ABCC1,NOM1,SN
RNP70,DDX23,RAD23A,METTL3,APITD1,USP47,ADAM8,NOL3,POLR3
E,GABPB1,PRPF40A,DNAJC10,RAB35,PCGF6,RANBP1,SIPA1L1,DDX
39A,KRIT1,SKIV2L,MINK1,RHOF,SUGP1,EEF1A1,LHX4,CSNK2A1,IGB
P1,UPF3A,NOD1,STAT2,RPP14,DHX9,PLK1,ZNF446,PNPO,PDE7B,AS
NS,TBC1D2B,DNM1L,PTGES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,PP
P5C,PDXK,CCNL1,HERC2,CHD6,ZC3H12A,TBC1D10B,SEPT4,POLM,S
LC11A2,SYMPK,EFTUD2,FAM58A,CNP,TBX18,GCDH,LBX2,PCGF1,D
R1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,TBC1D14,PRPF3,TNK2,
GIT2,WAC,ZNF142,FUBP3,MTG1,RARS,ZNF540,ALDH18A1,FGFR1,R
AB18,HSF4,PAIP1,GTF3C1,ERH,NADSYN1,PMS1,ADCY4,CELF1,PDE
4D,RNASET2,SF3A2,PAF1,TAB2,SGK1,PLEKHG4,DPF2,NADK,RNF8,S
EC31A,MDM2,ZFYVE26,PRKCH,PPM1F,ZNF595,TBP,DIS3L,YY1,FAM1
3A,INO80,GMEB2,PFDN5,CREB1,RALGPS2,FLII,PLEKHG5,RPRD1A,D
DX58,ALDH6A1,RPL27,CCNL2,PTPRK,SNX13,NF1,ZEB1,EIF4B,IFITM3
,ASCC2,RGMB,RTKN,EBF1,RPL9,MED28,NPR1,ZNF3,RPS6KA5,G3BP
1,NIPBL,RAB31,ALKBH3,ADSL,BRD9,ZNF837,PKD2,HNRNPA3,RXRB,
GALT,LMNA,MITF,NOL8,RB1,PRMT5,GNAI1,USP3,MZF1,ZFPM2,TP53
BP1,RNF168,PAFAH1B1,ZNF865,SENP2,TPP1,SUB1,CHMP1A,PDE8A,
NSA2,DDX6,ACAP2,ZNF558,MUM1,ZNF263,ZNF180,BICD1,ZNF276,R
GS3,NR1H3,GARS,CYTH2,PAN2,USP7,PLD6,FLCN,CUL4A,ZNF605,ZN
F410,FMO2,GMDS,RPL24,ARHGAP9,RPL37A,SAP30BP,VPS72,PTEN,I
DH1,SRPK1,RNASEK,RUNX2,CSTF1,IQGAP1,FBXW7,INTS4,SMARCD
3,HERPUD1,IKBKB,CTNS,RQCD1,KPNB1,SRGAP2,RFX7,NCOR1,ATP
11B,PPP1R10,MEF2A,PARN,FECH,SETD8,PIAS2,SSBP1,MAPK8,MYC
BP2,USP15,DDX41,SRRM2,PBX3,RNF213,ZNF565,ABCA2,AFF4,TRIM
28,DENND4C,DMTF1,MAP4K4,CDK5RAP2,ITPA,PTPRC,PSMC6,SWA
P70,TBCD,IMPDH1,UBP1,SKIV2L2,WDR61,EBF4,PRPF8,FARSA,ZNF1
48,ZNF76,PSMC4,HNRNPL,ARHGAP29,SGSM3,STAG2,SP110,GOPC,
PPA2,NCK2,RHEB,HNRNPH3,ZSWIM7,TCF4,ACD,IKZF5,HMGN2,WDR
4,SEMA4D,GNB3,SSBP2,ERC1,NFYC,P4HB,PIWIL4,RPUSD4,SRSF10,
G
O:
00
09
05
7
macromolecule catabolic process
G
O:
19
organic cyclic compound metabolic process
SS18,RCOR3,SMAD4,GRPEL2,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF4
4,CREBZF,ING4,RBMS1,ZNF687,CDC14B,CLK3,SLC23A2,NR2C2,FHO
D1,FIP1L1,DNTTIP2,FLNA,RAB5A,IRF9,ATP5A1,GLI3,TMED2,MAPK12,
CCDC59,DCAF6,RASGRF2,AK5,THOC2,ENG,SIRT7,ZSCAN5A,TCF12,
ARNT,NOX4,ZNF692,ERCC1,PHF1,STK36,WWP1,ATP8B2,ARHGEF7,
PHF12,PDIA5,ASAP1,REXO2,MED6,MDFI,ZNF554,IDH3B,NAA10,CIZ1,
RGS2,HINFP,NCBP2,MLX,PDGFRB,TGS1,NCAPD3,RAD51B,CDK11A,
GLIS3,ELP6,BDP1,FARP1,DBF4,RAP1B,RUNX1,SMARCA4,NAA16,LR
PPRC,YIF1A,RPLP0,DHX40,RAD54L2,CLASRP,ZNF518B,CRCP,CLK4,
ZNF90,ZNF638,PER3,TLN1,DOCK8,CHTF8,LONRF3,GSK3A,SNRPE,P
OLG,ZNF383,POLR2J3,NCOR2,FPGS,SETD2,PRPF4B,IGF2,PTGIS,FT
SJ3,TROVE2,MYO1E,ATXN3,PSTK,PHF21A,GPHN,PDCD4,SOX13,ERI
3,RGL2,CHD2,LONP2,PSMA1,STAT6,CARS2,ACIN1,PSD3,CSNK1E,S
ON,ZNF138,ZNF705A,CDK5RAP1,NSMCE4A,BNIP2,NTRK1,TFAM,SHP
RH,BRWD1,SMAD9,TGFBR3,ZFC3H1,ZBTB16,BAZ2A,UCK1,RRP8,VA
RS,LARS,PHF19,LMCD1,DHX37,LUC7L3
USP10,RNASEH2B,CRBN,PSMB10,XRN1,SIRT2,SPOP,UBXN1,SMAD7
,USP4,HDAC6,RNH1,HGS,DERL2,PNKP,PSMB9,RAD23A,USP47,ADA
M8,DNAJC10,CSNK2A1,UPF3A,PRKACA,ANAPC4,PLK1,UPF1,RC3H1,
HERC2,CLN8,USP20,WAC,PAIP1,RNASET2,RNF8,MDM2,RHBDD1,DI
biol
S3L,RPL27,RHBDF1,EIF4B,NUB1,RPL9,USP24,USP3,RNF168,RNF217
ogic
,TPP1,DDX6,USP33,PAN2,HEXA,USP7,CUL4A,CHFR,RPL24,RPL37A,
al_p
PTEN,FYN,FBXW7,HERPUD1,RQCD1,KPNB1,PARN,USP15,PSMC6,R
roce
NF146,PSMC4,SGSM3,PHKG2,OS9,SMAD4,TGFB1I1,RPL4,USP54,FL
ss
NA,HGSNAT,GUSB,ERCC1,GAA,WWP1,UBA6,NCBP2,LPCAT1,MAN1B
1,USP40,RPLP0,GSK3A,ATXN3,AMFR,PGM2,LONP2,PSMA1,CSNK1E,
CTBS,PHKG1,TSG101,KPNA1,ACAN,FMOD,PABPC1,UBR5,SMARCAD
1
biol FZD6,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX34,KAN
ogic K2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,IGF1R,PTS,MYO1D,
al_p SIRT2,EPHX2,RALGAPA2,MYNN,NOC2L,TARS,RAF1,ZNF131,SEPT5,
1.50
351
041
1.
7
8
E
0
5
1.14
254
039
1.
8
2
01
36
0
roce RSC1A1,SFSWAP,CDK13,RBM6,SIN3B,ATP2B1,CBX5,SART1,RAB34,
ss
SUPT5H,SUPT20H,PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,
GBP3,SHMT2,VAPB,CUX1,RBM17,CLNS1A,NUP98,EED,SMAD7,MCF2
L,PPFIBP2,HDAC6,ARHGEF12,EHMT1,ATP6V1D,RNH1,ZNF496,TYW1
B,NARS,LANCL2,H6PD,PNKP,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,E
MX2,ARHGEF25,RGL4,RBPMS,STARD13,ZSCAN31,XBP1,FDPS,PAM,
ABCC1,NOM1,SNRNP70,HSD17B12,DDX23,RAD23A,METTL3,APITD1,
USP47,ADAM8,NOL3,POLR3E,GABPB1,PRPF40A,DNAJC10,RAB35,P
CGF6,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,SUGP1,
EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,STAT2,RPP14,DHX9,PL
K1,ZNF446,PNPO,PDE7B,ASNS,TBC1D2B,DNM1L,PTGES2,UPF1,ZNF
621,HDGF,FDXR,RC3H1,PPP5C,PDXK,NPC1,CCNL1,HERC2,CHD6,ZC
3H12A,TBC1D10B,SEPT4,POLM,SLC11A2,SYMPK,EFTUD2,FAM58A,C
NP,CLN8,TBX18,GCDH,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,J
HDM1D,ZNF710,TBC1D14,PRPF3,TNK2,GIT2,WAC,ZNF142,FUBP3,MT
G1,RARS,ZNF540,ALDH18A1,FGFR1,RAB18,HSF4,PAIP1,GTF3C1,ER
H,NADSYN1,PMS1,ADCY4,CELF1,SNCAIP,PDE4D,RNASET2,SF3A2,P
AF1,TAB2,SGK1,PLEKHG4,DPF2,NADK,IDI1,RNF8,CYP2R1,SEC31A,
MDM2,ZFYVE26,PRKCH,PPM1F,ZNF595,TBP,DIS3L,YY1,FAM13A,INO
80,GMEB2,PFDN5,CREB1,RALGPS2,FLII,PLEKHG5,RPRD1A,DDX58,A
LDH6A1,RPL27,CCNL2,PTPRK,SNX13,NF1,ZEB1,ACAA1,EIF4B,IFITM
3,ASCC2,RGMB,RTKN,EBF1,RPL9,MED28,NPR1,ZNF3,RPS6KA5,G3B
P1,NIPBL,RAB31,ALKBH3,ADSL,BRD9,ZNF837,PKD2,HNRNPA3,RXRB
,GALT,LMNA,MITF,NOL8,RB1,PRMT5,GNAI1,USP3,MZF1,ZFPM2,TP53
BP1,RNF168,PAFAH1B1,ZNF865,SENP2,STARD3,TPP1,SUB1,CHMP1
A,PDE8A,NSA2,DDX6,ACAP2,ZNF558,MUM1,ZNF263,ZNF180,BICD1,Z
NF276,RGS3,NR1H3,GARS,CYTH2,PAN2,USP7,PLD6,FLCN,CUL4A,Z
NF605,ZNF410,FMO2,GMDS,RPL24,ARHGAP9,RPL37A,SAP30BP,VPS
72,PTEN,IDH1,SRPK1,RNASEK,RUNX2,CSTF1,IQGAP1,FBXW7,INTS4
,LGMN,SMARCD3,HERPUD1,IKBKB,CTNS,RQCD1,SNX17,KPNB1,SR
GAP2,RFX7,NCOR1,ATP11B,PPP1R10,MEF2A,PARN,FECH,SETD8,PI
AS2,SSBP1,MAPK8,MYCBP2,USP15,DDX41,SRRM2,PBX3,RNF213,ZN
7
E
0
5
G
O:
00
32
55
3
ribonucleotide binding
mol
ecul
ar_f
unct
ion
F565,ABCA2,AFF4,TRIM28,DENND4C,DMTF1,MAP4K4,CDK5RAP2,IT
PA,PTPRC,PSMC6,SWAP70,TBCD,IMPDH1,UBP1,SKIV2L2,WDR61,EB
F4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,ARHGAP29,SGSM
3,STAG2,SP110,GOPC,PPA2,NCK2,LEPR,RHEB,HNRNPH3,ZSWIM7,T
CF4,ACD,IKZF5,HMGN2,WDR4,SEMA4D,GNB3,SSBP2,ERC1,NFYC,P
4HB,HSD17B4,PIWIL4,RPUSD4,SRSF10,SS18,RCOR3,SMAD4,GRPEL
2,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF4
4,CREBZF,ING4,RBMS1,ZNF687,CDC14B,CLK3,SLC23A2,NR2C2,FHO
D1,FIP1L1,DNTTIP2,FLNA,RAB5A,IRF9,ATP5A1,GLI3,TMED2,MAPK12,
CCDC59,DCAF6,RASGRF2,AK5,THOC2,ENG,SIRT7,ZSCAN5A,TCF12,
ARNT,NOX4,ZNF692,ERCC1,PHF1,STK36,WWP1,ATP8B2,ARHGEF7,
PHF12,PDIA5,ASAP1,REXO2,MED6,MDFI,ZNF554,IDH3B,NAA10,CIZ1,
RGS2,HINFP,NCBP2,MLX,PDGFRB,EBPL,TGS1,NCAPD3,RAD51B,CD
K11A,GLIS3,ELP6,BDP1,FARP1,DBF4,RAP1B,RUNX1,SMARCA4,NAA
16,LRPPRC,YIF1A,RPLP0,DHX40,RAD54L2,CLASRP,ZNF518B,CRCP,
CLK4,ZNF90,ZNF638,PER3,TLN1,DOCK8,CHTF8,LONRF3,GSK3A,SN
RPE,POLG,ZNF383,POLR2J3,NCOR2,FPGS,SETD2,PRPF4B,IGF2,PT
GIS,FTSJ3,TROVE2,MYO1E,ATXN3,PSTK,PHF21A,GPHN,PDCD4,SOX
13,ERI3,RGL2,CHD2,LONP2,PSMA1,STAT6,CARS2,ACIN1,PSD3,CSN
K1E,SON,ZNF138,ZNF705A,CDK5RAP1,NSMCE4A,BNIP2,NTRK1,TFA
M
CDK14,DHX34,EIF2B4,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,S
EPT5,CDK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,M
CF2L,ARHGEF12,VRK2,TYW1B,NARS,LANCL2,DGKA,PNKP,ARHGEF
25,RGL4,STARD9,ABCC1,DDX23,MARK4,UHMK1,RAB35,RANBP1,DD
X39A,SKIV2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,
DHX9,PLK1,PNPO,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,HERC2,CHD6
,SEPT4,EFTUD2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,AL
DH18A1,FGFR1,RAB18,NADSYN1,PMS1,ADCY4,PDE4D,SGK1,PLEKH
G4,CHKB,NADK,PRKCH,IDH3G,INO80,RALGPS2,NAGK,PLEKHG5,DD
X58,MAGI1,NEK3,RTKN,NPR1,RPS6KA5,G3BP1,RAB31,NTPCR,UBE2
1.31
242
471
1.
9
2
E
0
5
G
O:
00
19
89
9
G
O:
00
70
16
1
enzyme binding
mol
ecul
ar_f
unct
ion
anchoring junction
cell
ular
_co
mpo
nent
Q1,GNAI1,MARK3,SLFN11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,M
AST2,FYN,SRPK1,RUNX2,IKBKB,ATP11B,ERAL1,STK19,MAPK8,MYLK
,DDX41,RNF213,ABCA2,RAB8A,DENND4C,MAP4K4,CSK,PSMC6,SWA
P70,SKIV2L2,CDK6,FARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,PAK1,R
AB10,RHEB,TRPM7,CSF1R,DGKZ,ACTR2,DTYMK,MTRR,CLK3,RAB5A
,BCS1L,ATP5A1,NDUFV1,MAPK12,RASGRF2,AK5,NRBP2,STK36,ATP
8B2,ARHGEF7,UBA6,NUBP1,PDGFRB,RAD51B,CDK11A,MYO7B,FAR
P1,RAP1B,RUNX1,MKNK2,SMARCA4,DHX40,RAD54L2,KIF13B,CLK4,
DOCK8,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO1E,PSTK,GP
HN,ARL15,RGL2,CHD2,RABL3,LONP2,CARS2,PSD3,CSNK1E,NTRK1,
SHPRH,PHKG1,UCK1,VARS,LARS,DHX37,SEPT2,PDPK1,STK24,RAP
GEF6,GAK,RBKS,PANK3,FASTK,SMARCAD1,WNK1,DENND6B
FZD6,LAMB1,SIRT2,UTRN,RAF1,NLRP1,GAS8,SPOP,CBX5,SUPT5H,
MARCH5,UBXN1,DPP4,PTPN22,VAPB,SMAD7,HDAC6,SYTL4,PAM,UH
MK1,DNAJC10,RANBP1,MARCH6,PDLIM5,PTPN6,EEF1A1,IGBP1,PRK
ACA,ANAPC4,PLK1,DNM1L,CCNL1,HERC2,FAM58A,TBC1D14,WAC,S
TK11IP,TPCN2,SNCAIP,PDE4D,PAF1,RNF8,MDM2,PRKCH,DIS3L,CCN
L2,PTPRK,RTKN,NPR1,NIPBL,PKD2,CASP2,STRN4,PPP1R21,RB1,MA
PK8IP3,PAFAH1B1,SYTL2,BICD1,USP7,CUL4A,DAAM1,MAST2,FAP,P
TEN,IQGAP1,IKBKB,PXN,SRGAP2,LTBR,NCOR1,MEF2A,DYM,PARN,P
RKRIP1,MAPK8,RAB8A,TRIM28,CSK,CDK5RAP2,PTPRC,SGSM3,RAN
BP9,PAK1,RHEB,ACD,GNB3,ATP6V0A1,ERC1,OS9,TANK,LRPAP1,FL
NA,GLI3,ARHGEF7,HINFP,TNFRSF14,RAP1B,LMNB1,RAD54L2,KIF13
B,GSK3A,POLG,NCOR2,ATXN3,LONP2,ACIN1,CDK5RAP1,SPRED1,P
HKG1,ATG3,PKD1,PDPK1,TSG101,USF1,CDK5RAP3,RAPGEF6,WNK1
LPP,EPHX2,SMAD7,VASP,TNK2,SIKE1,AFAP1,TLN2,FLII,PTPRK,NEX
N,ESAM,ARPC2,ADAM15,TENC1,PXN,TNS1,ITGB5,PTPRC,TBCD,PAK
1,TGFB1I1,EZR,VEZT,NOX4,ARHGEF7,ITGA5,TLN1,MYO1E,LIMS2,LU
C7L3,PDPK1,GAK
1.44
759
129
5
2.
1
6
E
0
5
2.13
786
952
1
2.
7
3
E
0
5
G
O:
00
17
07
6
G
O:
00
06
80
7
purine nucleotide binding
nitrogen compound metabolic process
CDK14,DHX34,EIF2B4,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,S
EPT5,CDK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,M
CF2L,ARHGEF12,VRK2,NARS,LANCL2,DGKA,PNKP,ARHGEF25,RGL4
,STARD9,ABCC1,DDX23,MARK4,UHMK1,RAB35,RANBP1,DDX39A,SKI
V2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PL
K1,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD
2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,ALDH18A1,FGFR1
,RAB18,NADSYN1,PMS1,ADCY4,PDE4D,SGK1,PLEKHG4,CHKB,NADK
,PRKCH,IDH3G,INO80,RALGPS2,NAGK,PLEKHG5,DDX58,FAM114A2,
mol
MAGI1,NEK3,RTKN,NPR1,RPS6KA5,G3BP1,RAB31,NTPCR,UBE2Q1,G
ecul
NAI1,MARK3,SLFN11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,MAST
ar_f
2,FYN,SRPK1,RUNX2,IKBKB,ATP11B,ERAL1,STK19,MAPK8,MYLK,DD
unct
X41,RNF213,ABCA2,RAB8A,DENND4C,MAP4K4,CSK,PSMC6,SWAP70
ion
,SKIV2L2,CDK6,FARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,PAK1,RAB
10,RHEB,TRPM7,CSF1R,DGKZ,ACTR2,GRPEL2,DTYMK,CLK3,RAB5A,
BCS1L,ATP5A1,MAPK12,RASGRF2,AK5,NRBP2,STK36,ATP8B2,ARHG
EF7,UBA6,NUBP1,PDGFRB,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,
RUNX1,MKNK2,SMARCA4,DHX40,RAD54L2,KIF13B,CLK4,DOCK8,AD
RBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO1E,PSTK,GPHN,ARL15,
RGL2,CHD2,RABL3,LONP2,CARS2,PSD3,CSNK1E,NTRK1,SHPRH,PH
KG1,UCK1,VARS,LARS,DHX37,SEPT2,PDPK1,STK24,RAPGEF6,GAK,
RBKS,PANK3,FASTK,SMARCAD1,WNK1,DENND6B
FZD6,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX34,KAN
K2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,CKB,IGF1R,PTS,MY
O1D,SIRT2,RALGAPA2,MYNN,NOC2L,TARS,RAF1,ZNF131,SEPT5,RS
biol
C1A1,SFSWAP,CDK13,RBM6,SIN3B,ATP2B1,CBX5,SART1,RAB34,SU
ogic
PT5H,SUPT20H,ST3GAL1,PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,
al_p
ENOSF1,MMS19,GBP3,SHMT2,VAPB,CUX1,RBM17,CLNS1A,NUP98,E
roce
ED,AMT,SMPD4,SMAD7,MCF2L,PPFIBP2,HDAC6,ARHGEF12,EHMT1,
ss
ATP6V1D,RNH1,ZNF496,TYW1B,NARS,LANCL2,H6PD,PNKP,LEF1,GL
S,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,RGL4,RBPMS,XY
LT1,STARD13,ZSCAN31,XBP1,PAM,ABCC1,NOM1,SNRNP70,DDX23,
1.30
496
924
3.
0
3
E
0
5
1.13
176
545
7
3.
0
6
E
0
5
RAD23A,METTL3,APITD1,USP47,ADAM8,NOL3,POLR3E,GABPB1,PRP
F40A,DNAJC10,RAB35,PCGF6,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV
2L,MINK1,RHOF,SUGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1
,STAT2,RPP14,DHX9,PLK1,ZNF446,PNPO,PDE7B,ASNS,TBC1D2B,DN
M1L,PTGES2,UPF1,ZNF621,HDGF,FDXR,RC3H1,PPP5C,PDXK,CCNL1
,HERC2,CHD6,ZC3H12A,TBC1D10B,SEPT4,POLM,SLC11A2,SYMPK,E
FTUD2,FAM58A,CNP,CLN8,TBX18,GCDH,LBX2,PCGF1,DR1,BCLAF1,
ZNF721,ZNF397,JHDM1D,ZNF710,DNPEP,TBC1D14,PRPF3,TNK2,GIT
2,WAC,ZNF142,FUBP3,MTG1,RARS,ZNF540,ALDH18A1,FGFR1,RAB1
8,HSF4,PAIP1,GTF3C1,ERH,NADSYN1,PMS1,ADCY4,CELF1,SNCAIP,
PDE4D,RNASET2,SF3A2,PAF1,TAB2,SGK1,PLEKHG4,DPF2,CHKB,NA
DK,RNF8,SEC31A,MDM2,FKBP1A,ZFYVE26,PRKCH,PPM1F,ZNF595,T
BP,DIS3L,YY1,FAM13A,INO80,GMEB2,PFDN5,CREB1,RALGPS2,FLII,P
LEKHG5,RPRD1A,DDX58,ALDH6A1,RPL27,CCNL2,PTPRK,SNX13,NF1
,ZEB1,EIF4B,IFITM3,ASCC2,RGMB,RTKN,EBF1,RPL9,MED28,NPR1,Z
NF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ST3GAL4,BRD9,G
CNT2,ZNF837,PKD2,HNRNPA3,RXRB,GALT,LMNA,MITF,NOL8,RB1,P
RMT5,GNAI1,USP3,MZF1,ZFPM2,TP53BP1,RNF168,PAFAH1B1,ZNF86
5,SENP2,TPP1,SUB1,CHMP1A,PDE8A,NSA2,DDX6,ACAP2,ZNF558,M
UM1,ZNF263,ZNF180,BICD1,ZNF276,RGS3,NR1H3,GARS,CYTH2,PAN
2,HEXA,USP7,PLD6,FLCN,CUL4A,ZNF605,ZNF410,FMO2,GMDS,RPL2
4,ARHGAP9,UST,RPL37A,SAP30BP,VPS72,PTEN,IDH1,SRPK1,RNAS
EK,RUNX2,CSTF1,IQGAP1,FBXW7,INTS4,SMARCD3,HERPUD1,IKBK
B,CTNS,RQCD1,KPNB1,SRGAP2,RFX7,NCOR1,ATP11B,PPP1R10,ME
F2A,PARN,FECH,SETD8,PIAS2,SSBP1,MAPK8,MYCBP2,USP15,DDX4
1,SRRM2,PBX3,RNF213,ZNF565,ABCA2,AFF4,TRIM28,DENND4C,DM
TF1,MAP4K4,CDK5RAP2,ITPA,PTPRC,OAZ1,PSMC6,SWAP70,TBCD,I
MPDH1,UBP1,SKIV2L2,WDR61,EBF4,PRPF8,FARSA,ZNF148,ZNF76,P
SMC4,HNRNPL,ARHGAP29,SGSM3,STAG2,SP110,GOPC,PPA2,ST6G
ALNAC5,NCK2,RHEB,HNRNPH3,CTSH,ZSWIM7,TCF4,ACD,IKZF5,HM
GN2,WDR4,SEMA4D,GNB3,SSBP2,ERC1,NFYC,P4HB,ELOVL1,PIWIL4
,RPUSD4,SRSF10,SS18,RCOR3,SMAD4,GRPEL2,CHURC1,CHURC1-
G
O:
00
34
64
1
cellular nitrogen compound metabolic
process
FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,DDAH1,INO80E,DTYMK,RP
L4,MTRR,MBOAT2,ZNF44,CREBZF,ING4,RBMS1,ZNF687,CDC14B,CL
K3,SLC23A2,NR2C2,FHOD1,FIP1L1,DLST,DNTTIP2,FLNA,RAB5A,IRF9
,HGSNAT,ATP5A1,GLI3,TMED2,THNSL2,MAPK12,CCDC59,DCAF6,RA
SGRF2,AK5,GUSB,THOC2,B4GALT4,ENG,SIRT7,ZSCAN5A,TCF12,AR
NT,NOX4,ZNF692,EXT1,ERCC1,PHF1,B3GAT3,STK36,WWP1,ATP8B2,
ARHGEF7,PHF12,PDIA5,ASAP1,REXO2,MED6,MDFI,ZNF554,IDH3B,N
AA10,CIZ1,RGS2,HINFP,NCBP2,LPCAT1,MLX,PDGFRB,TGS1,NCAPD
3,RAD51B,CDK11A,GLIS3,ELP6,NIT1,BDP1,FARP1,DBF4,RAP1B,RUN
X1,SMARCA4,NAA16,LRPPRC,YIF1A,RPLP0,DHX40,RAD54L2,CLASR
P,ZNF518B,CRCP,CLK4,ZNF90,ZNF638,PER3,TLN1,DOCK8,CHTF8,L
ONRF3,GSK3A,SNRPE,POLG,ZNF383,POLR2J3,NCOR2,FPGS,SETD2
,PCYT1A,PPAP2A,PRPF4B,IGF2,PTGIS,FTSJ3,TROVE2,MYO1E,ATXN
3,PSTK,PHF21A,GPHN,PDCD4
FZD6,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX34,KAN
K2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,CKB,IGF1R,PTS,MY
O1D,SIRT2,RALGAPA2,MYNN,NOC2L,TARS,RAF1,ZNF131,SEPT5,RS
C1A1,SFSWAP,CDK13,RBM6,SIN3B,ATP2B1,CBX5,SART1,RAB34,SU
PT5H,SUPT20H,PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,GB
P3,VAPB,CUX1,RBM17,CLNS1A,NUP98,EED,SMPD4,SMAD7,MCF2L,P
PFIBP2,HDAC6,ARHGEF12,EHMT1,ATP6V1D,RNH1,ZNF496,TYW1B,N
biol
ARS,LANCL2,H6PD,PNKP,LEF1,GLS,PAX8,SUPT4H1,ZNF83,PSMB9,E
ogic
MX2,ARHGEF25,RGL4,RBPMS,STARD13,ZSCAN31,XBP1,PAM,ABCC
al_p
1,NOM1,SNRNP70,DDX23,RAD23A,METTL3,APITD1,USP47,ADAM8,N
roce
OL3,POLR3E,GABPB1,PRPF40A,DNAJC10,RAB35,PCGF6,RANBP1,SI
ss
PA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,SUGP1,EEF1A1,LHX4,CS
NK2A1,IGBP1,UPF3A,NOD1,STAT2,RPP14,DHX9,PLK1,ZNF446,PNPO
,PDE7B,ASNS,TBC1D2B,DNM1L,PTGES2,UPF1,ZNF621,HDGF,FDXR,
RC3H1,PPP5C,PDXK,CCNL1,HERC2,CHD6,ZC3H12A,TBC1D10B,SEP
T4,POLM,SLC11A2,SYMPK,EFTUD2,FAM58A,CNP,TBX18,GCDH,LBX2
,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,DNPEP,TBC1
D14,PRPF3,TNK2,GIT2,WAC,ZNF142,FUBP3,MTG1,RARS,ZNF540,AL
1.13
772
663
1
3.
2
0
E
0
5
DH18A1,FGFR1,RAB18,HSF4,PAIP1,GTF3C1,ERH,NADSYN1,PMS1,A
DCY4,CELF1,PDE4D,RNASET2,SF3A2,PAF1,TAB2,SGK1,PLEKHG4,D
PF2,CHKB,NADK,RNF8,SEC31A,MDM2,FKBP1A,ZFYVE26,PRKCH,PP
M1F,ZNF595,TBP,DIS3L,YY1,FAM13A,INO80,GMEB2,PFDN5,CREB1,R
ALGPS2,FLII,PLEKHG5,RPRD1A,DDX58,ALDH6A1,RPL27,CCNL2,PTP
RK,SNX13,NF1,ZEB1,EIF4B,IFITM3,ASCC2,RGMB,RTKN,EBF1,RPL9,
MED28,NPR1,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,BR
D9,ZNF837,PKD2,HNRNPA3,RXRB,GALT,LMNA,MITF,NOL8,RB1,PRM
T5,GNAI1,USP3,MZF1,ZFPM2,TP53BP1,RNF168,PAFAH1B1,ZNF865,S
ENP2,TPP1,SUB1,CHMP1A,PDE8A,NSA2,DDX6,ACAP2,ZNF558,MUM
1,ZNF263,ZNF180,BICD1,ZNF276,RGS3,NR1H3,GARS,CYTH2,PAN2,U
SP7,PLD6,FLCN,CUL4A,ZNF605,ZNF410,FMO2,GMDS,RPL24,ARHGA
P9,RPL37A,SAP30BP,VPS72,PTEN,IDH1,SRPK1,RNASEK,RUNX2,CS
TF1,IQGAP1,FBXW7,INTS4,SMARCD3,HERPUD1,IKBKB,CTNS,RQCD
1,KPNB1,SRGAP2,RFX7,NCOR1,ATP11B,PPP1R10,MEF2A,PARN,FEC
H,SETD8,PIAS2,SSBP1,MAPK8,MYCBP2,USP15,DDX41,SRRM2,PBX3
,RNF213,ZNF565,ABCA2,AFF4,TRIM28,DENND4C,DMTF1,MAP4K4,CD
K5RAP2,ITPA,PTPRC,OAZ1,PSMC6,SWAP70,TBCD,IMPDH1,UBP1,SK
IV2L2,WDR61,EBF4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,A
RHGAP29,SGSM3,STAG2,SP110,GOPC,PPA2,NCK2,RHEB,HNRNPH3
,CTSH,ZSWIM7,TCF4,ACD,IKZF5,HMGN2,WDR4,SEMA4D,GNB3,SSB
P2,ERC1,NFYC,PIWIL4,RPUSD4,SRSF10,SS18,RCOR3,SMAD4,GRPE
L2,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,DDAH1,INO80E,DTYMK,RP
L4,MTRR,MBOAT2,ZNF44,CREBZF,ING4,RBMS1,ZNF687,CDC14B,CL
K3,SLC23A2,NR2C2,FHOD1,FIP1L1,DLST,DNTTIP2,FLNA,RAB5A,IRF9
,ATP5A1,GLI3,TMED2,MAPK12,CCDC59,DCAF6,RASGRF2,AK5,THOC
2,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZNF692,ERCC1,PHF1,ST
K36,WWP1,ATP8B2,ARHGEF7,PHF12,PDIA5,ASAP1,REXO2,MED6,M
DFI,ZNF554,IDH3B,NAA10,CIZ1,RGS2,HINFP,NCBP2,LPCAT1,MLX,PD
GFRB,TGS1,NCAPD3,RAD51B,CDK11A,GLIS3,ELP6,BDP1,FARP1,DB
F4,RAP1B,RUNX1,SMARCA4,NAA16,LRPPRC,YIF1A,RPLP0,DHX40,R
G
O:
00
33
03
6
G
O:
00
32
98
macromolecule localization
cellular component morphogenesis
AD54L2,CLASRP,ZNF518B,CRCP,CLK4,ZNF90,ZNF638,PER3,TLN1,D
OCK8,CHTF8,LONRF3,GSK3A,SNRPE,POLG,ZNF383,POLR2J3,NCOR
2,FPGS,SETD2,PCYT1A,PRPF4B,IGF2,PTGIS,FTSJ3,TROVE2,MYO1E
,ATXN3,PSTK,PHF21A,PDCD4,SOX13,ERI3,RGL2,CHD2,LONP2,PSMA
1,STAT6,CARS2,ACIN1,PSD3,CSNK1E,SON,ZNF138,ZNF705A,CDK5R
AP1,NSMCE4A,BNIP2,NTRK1,TFAM,SHPRH,BRWD1,SMAD9,HBB
RAB3GAP2,CADM1,RALGAPA2,BTN3A1,NLRP1,GAS8,CPE,CCDC91,
RAB34,MARCH5,BCL6,GPAA1,NUP98,FMR1,SMAD7,USP4,HDAC6,AT
P6V1D,HGS,DERL2,SYTL4,RBPMS,COG4,PAM,AP3S2,UHMK1,ADAM
8,RAB35,DDX39A,KPNA6,UPF3A,PRKACA,PLK1,VPS52,LMAN2,NUTF
2,DNM1L,UPF1,NPC1,HERC2,ZC3H12A,NUP210,RAB24,ATG4B,CLN8,
VAMP7,FYTTD1,BBS1,STK11IP,VTI1A,HPS4,RAB18,DISP1,TIMM23,C
PT1B,SEC31A,MDM2,SNAP23,SFT2D2,YY1,TLN2,MCFD2,SRP9,DDX5
8,RPL27,LCP2,PTPRK,SNX13,AP4B1,RHBDF1,SNX21,NF1,RPL9,NIPB
biol L,RAB31,PKD2,LMNA,RSL1D1,RB1,MAPK8IP3,STX16,PAFAH1B1,SEN
ogic P2,STARD3,SYTL2,CHMP1A,SYNE1,BICD1,GCC2,NR1H3,HEXA,FLCN
al_p ,RPL24,RPL37A,STX2,FBXW7,CEP112,SNX17,KPNB1,NCOR1,ATP11B
roce ,PPP1R10,NECAB3,CACNB1,MAPK8,MYCBP2,CLTCL1,OSBPL3,ABCA
ss
2,RAB8A,DENND4C,CSK,STX18,NUP37,CLTB,FLOT1,AAK1,GOPC,PA
K1,LEPROT,RAB10,VPS45,ACD,CSF1R,ATP6V0A1,ERC1,TIMM50,OS9
,C3,SRSF10,TMED3,SMAD4,GRPEL2,C1QTNF3,EZR,RPL4,APOL3,FL
NA,RAB5A,SUN2,GLI3,TMED2,THOC2,MCOLN1,SCFD1,VTI1B,SLC25
A6,ATP8B2,VAMP4,MDFI,NUP85,HINFP,STAM2,NCBP2,VPS51,CANX,
RUNX1,LRPPRC,YIF1A,RPLP0,SDAD1,SNX27,KIF13B,RHBDF2,TLN1,
NLGN2,TWF1,ATG4A,PDIA3,ATG16L2,SNX14,LONP2,CSNK1E,ATG3,L
MF1,SEC31B,SPCS3,SEPT2,PKD1,PDPK1,TSG101,KPNA1,CD63,SCA
MP1,UBR5,CLASP1,GORASP1,PABPN1
biol FZD6,CADM1,PSMB10,IGF1R,LAMB1,NPHP3,RAF1,COL9A1,BDNF,CO
ogic L2A1,BCL6,SMAD7,ARHGEF12,CD72,TTLL3,LEF1,PAX8,ITGA9,ADAM
al_p 8,CAPZB,PRPF40A,CD9,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,
roce CSNK2A1,DNM1L,SLC11A2,CNP,BBS1,STK4,FGFR1,CAPRIN1,KIAA05
ss
86,SSH2,CREB1,RGMB,COL18A1,RPS6KA5,RB1,MAPK8IP3,PAFAH1B
1.31
440
317
3.
3
0
E
0
5
1.45
331
604
2
3.
3
3
E
-
9
G
O:
19
01
36
3
heterocyclic compound binding
mol
ecul
ar_f
unct
ion
1,ARPC2,ADAM15,USP33,HEXA,NRP1,PTEN,FYN,IFT172,SRGAP2,ME
F2A,TCTN1,SSBP1,CACNB1,MYCBP2,RAB8A,TRIM28,COL9A3,PTPR
C,FLOT1,RANBP9,WDR35,PAK1,NCK2,RAB10,SEMA6A,SEMA4D,CSF
1R,ROBO3,SS18,SMAD4,TGFB1I1,EZR,FLNA,GLI3,NOX4,EXT1,STK36
,TBCE,ASAP1,UNC5B,PTPRD,ITGA5,PDGFRB,DZIP1,CC2D2A,FARP1,
SMARCA4,KIF13B,PTPN23,TLN1,TROVE2,ROBO2,CACNB3,PMP22,C
LIC4,NTRK1,BRWD1,TGFBR3,TMEM237,SEPT2,FOXC1,STK24,SSH1,
C2CD3,CLASP1,TENM4
CDK14,OBFC1,PBX2,DHX34,ACADVL,EIF2B4,GTF3C2,XRN1,CKB,IGF
1R,GK5,TNRC6A,MYO1D,SIRT2,MYNN,TRNAU1AP,TARS,RAF1,NLRP
1,ZNF131,SEPT5,SFSWAP,CDK13,RBM6,ATP2B1,RAB34,ERCC6L2,B
CL6,FUBP1,ZNF783,CMPK2,TBX2,GBP3,ZFP91,EEF2K,CUX1,PGS1,R
BM17,SLC9B2,FMR1,SMAD7,MCF2L,PPFIBP2,ARHGEF12,VRK2,ZNF4
96,TYW1B,NARS,LANCL2,H6PD,DGKA,PNKP,LEF1,PAX8,ZNF83,EMX
2,ARHGEF25,RGL4,RBPMS,ZSCAN31,STARD9,XBP1,ABCC1,NOM1,S
NRNP70,HSD17B12,DDX23,RAD23A,METTL3,APITD1,MARK4,UHMK1,
NOL3,GABPB1,RAB35,PCGF6,RANBP1,DDX39A,SKIV2L,MINK1,RHOF
,SUGP1,EEF1A1,ACTR3,LHX4,CSNK2A1,UPF3A,NOD1,PRKACA,STAT
2,RPP14,DHX9,PLK1,ZNF446,PNPO,ASNS,DNM1L,PTGES2,TNRC18,
UPF1,ZNF621,HDGF,FDXR,RC3H1,PDXK,RHOBTB1,HERC2,CHD6,SE
PT4,POLM,EFTUD2,RAB24,CNP,TBX18,GCDH,LBX2,DR1,BCLAF1,CA
MK2D,FYTTD1,ZNF721,ZNF397,ZNF710,DHRSX,GALK2,PRPF3,TNK2,
STK4,ZNF142,FUBP3,MTG1,RARS,ZNF540,ALDH18A1,FGFR1,RAB18,
HSF4,PAIP1,CAPRIN1,GTF3C1,NADSYN1,PMS1,ADCY4,CELF1,PDE4
D,RNASET2,SF3A2,SGK1,PLEKHG4,CHKB,NADK,CYP2R1,FKBP1A,Z
CCHC14,PRKCH,DAZAP1,ZNF595,TBP,DIS3L,IDH3G,YY1,INO80,GME
B2,SSH2,CREB1,SRP9,RALGPS2,NAGK,PLEKHG5,DDX58,ZCCHC9,F
AM114A2,MAGI1,ZEB1,NEK3,EIF4B,CRIP1,SERBP1,SETBP1,RTKN,EB
F1,RPL9,FKBP10,UNKL,NPR1,ZNF3,RPS6KA5,G3BP1,RAB31,BRD9,N
TPCR,ZNF837,HNRNPA3,RXRB,UBE2Q1,RSL1D1,MITF,NOL8,RB1,HM
GXB3,GNAI1,DHRS1,MZF1,ZFPM2,TP53BP1,MARK3,ZNF865,ISYNA1,
PUM2,SLFN11,SUB1,FAM200B,AACS,STK38L,DDX6,ZNF558,ZNF263,
0
5
1.15
162
670
1
3.
5
2
E
0
5
G
O:
00
purine ribonucleoside binding
mol
ecul
ar_f
ZNF180,BICD1,ZNF276,NR1H3,GARS,CYTH2,MRPS7,PLK2,PAN2,ZNF
605,CHFR,ZNF410,PTGR2,FMO2,GMDS,RPL24,MAST2,VPS72,FYN,AL
DH1A3,IDH1,SRPK1,RUNX2,CSTF1,IKBKB,RFX7,NCOR1,ATP11B,PPP
1R10,MEF2A,PARN,FECH,ERAL1,PRKRIP1,STK19,PIAS2,SSBP1,MAP
K8,MYLK,DDX41,SRRM2,PBX3,RNF213,N6AMT1,ZNF565,ABCA2,RAB
8A,TRIM28,DENND4C,DMTF1,MAP4K4,CSK,CDK5RAP2,ITPA,PSMC6,
SWAP70,IMPDH1,UBP1,SKIV2L2,CDK6,EBF4,PRPF8,FARSA,ZNF148,
ZNF76,PSMC4,HNRNPL,KIFC2,UBA2,AAK1,SP110,PHKG2,PAK1,RAB1
0,RHEB,HNRNPH3,TCF4,ACD,TRPM7,IKZF5,HMGN2,SSBP2,CSF1R,TI
MM50,DGKZ,ACTR2,NFYC,HSD17B4,PIWIL4,RPUSD4,SRSF10,RCOR
3,SMAD4,GRPEL2,ZNF114,MIER2,NAV1,DTYMK,RPL4,MTRR,CENPT,
ZNF44,CREBZF,RBMS1,EIF3M,ZNF687,CLK3,NR2C2,FIP1L1,RAB5A,I
RF9,BCS1L,ATP5A1,GLI3,NDUFV1,MAPK12,NDUFS2,RASGRF2,AK5,T
HOC2,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZNF692,ETFA,GAPDH,ER
CC1,MTRF1L,BICC1,NRBP2,STK36,SDHA,ATP8B2,ARHGEF7,REXO2,
MED6,MDFI,CIRBP,UBA6,ZNF554,IDH3B,PTGR1,NUBP1,CIZ1,HINFP,
NCBP2,MLX,PDGFRB,RAD51B,CDK11A,GLIS3,BDP1,MYO7B,FARP1,
DBF4,RAP1B,RUNX1,MKNK2,SMARCA4,LRPPRC,RPLP0,DHX40,RAD
54L2,ZNF518B,KIF13B,CRCP,CLK4,ZNF90,ZNF638,DOCK8,ADRBK2,C
HTF8,PHC3,DNAJC21,GSK3A,SIK3,SNRPE,THUMPD2,POLG,ZNF383,
MRPL3,POLR2J3,NCOR2,FPGS,SETD2,TWF1,PRPF4B,PTGIS,TROVE
2,MYO1E,D2HGDH,ATXN3,NUCB1,PSTK,PHF21A,GPHN,PDCD4,ARL1
5,SOX13,ERI3,RGL2,CHD2,RABL3,LONP2,ZBED5,PSMA1,STAT6,CAR
S2,ACIN1,PSD3,CSNK1E,SON,ZNF138,ZNF705A,NTRK1,TFAM,SHPR
H,PHKG1,SMAD9,HBB,ZBTB16,BAZ2A,SIRT3,UCK1,EIF3I,VARS,LARS
,DHX37,SEPT2,LUC7L3,PDPK1,TSG101,THAP6,USF1,FOXC1,ZC3H14,
STK24,HEMK1,SSH1,RAPGEF6,GAK,MTO1,PABPC1,RBKS,PANK3,UB
R5,FASTK,PHC2,SMARCAD1,WNK1,CC2D1A,ZC3H15,DENND6B,PGR
MC2,GATA2,PABPN1
CDK14,DHX34,EIF2B4,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,S
EPT5,CDK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,M
CF2L,ARHGEF12,VRK2,NARS,LANCL2,DGKA,PNKP,ARHGEF25,RGL4
1.30
428
670
3.
6
5
32
55
0
G
O:
00
08
10
4
unct
ion
protein localization
,STARD9,ABCC1,DDX23,MARK4,UHMK1,RAB35,RANBP1,DDX39A,SKI
V2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PL
K1,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD
2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,ALDH18A1,FGFR1
,RAB18,NADSYN1,PMS1,ADCY4,SGK1,PLEKHG4,CHKB,NADK,PRKC
H,IDH3G,INO80,RALGPS2,NAGK,PLEKHG5,DDX58,MAGI1,NEK3,RTK
N,NPR1,RPS6KA5,G3BP1,RAB31,NTPCR,UBE2Q1,GNAI1,MARK3,SLF
N11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,MAST2,FYN,SRPK1,RU
NX2,IKBKB,ATP11B,ERAL1,STK19,MAPK8,MYLK,DDX41,RNF213,ABC
A2,RAB8A,DENND4C,MAP4K4,CSK,PSMC6,SWAP70,SKIV2L2,CDK6,F
ARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,PAK1,RAB10,RHEB,TRPM7,
CSF1R,DGKZ,ACTR2,DTYMK,CLK3,RAB5A,BCS1L,ATP5A1,MAPK12,R
ASGRF2,AK5,NRBP2,STK36,ATP8B2,ARHGEF7,UBA6,NUBP1,PDGFR
B,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RUNX1,MKNK2,SMARCA4,
DHX40,RAD54L2,KIF13B,CLK4,DOCK8,ADRBK2,GSK3A,SIK3,FPGS,T
WF1,PRPF4B,MYO1E,PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP2,
CARS2,PSD3,CSNK1E,NTRK1,SHPRH,PHKG1,UCK1,VARS,LARS,DH
X37,SEPT2,PDPK1,STK24,RAPGEF6,GAK,RBKS,PANK3,FASTK,SMAR
CAD1,WNK1,DENND6B
RAB3GAP2,CADM1,RALGAPA2,BTN3A1,NLRP1,GAS8,CPE,CCDC91,
RAB34,MARCH5,BCL6,GPAA1,NUP98,SMAD7,USP4,HDAC6,ATP6V1D
,HGS,DERL2,SYTL4,RBPMS,COG4,PAM,AP3S2,UHMK1,ADAM8,RAB3
5,KPNA6,PRKACA,PLK1,VPS52,LMAN2,NUTF2,DNM1L,HERC2,NUP21
biol 0,RAB24,ATG4B,VAMP7,BBS1,STK11IP,VTI1A,HPS4,RAB18,DISP1,TI
ogic MM23,SEC31A,MDM2,SNAP23,SFT2D2,TLN2,MCFD2,SRP9,DDX58,R
al_p PL27,LCP2,PTPRK,SNX13,AP4B1,RHBDF1,SNX21,NF1,RPL9,NIPBL,R
roce AB31,PKD2,LMNA,RSL1D1,RB1,MAPK8IP3,STX16,PAFAH1B1,SENP2,
ss
SYTL2,CHMP1A,SYNE1,BICD1,GCC2,NR1H3,FLCN,RPL24,RPL37A,ST
X2,FBXW7,CEP112,SNX17,KPNB1,PPP1R10,NECAB3,CACNB1,MAPK
8,MYCBP2,CLTCL1,RAB8A,DENND4C,CSK,STX18,NUP37,CLTB,FLOT
1,AAK1,GOPC,PAK1,LEPROT,RAB10,VPS45,ACD,CSF1R,ATP6V0A1,E
RC1,TIMM50,OS9,TMED3,SMAD4,GRPEL2,C1QTNF3,EZR,RPL4,FLNA
6
1.34
396
517
5
E
0
5
3.
7
8
E
0
5
G
O:
00
43
16
7
ion binding
mol
ecul
ar_f
unct
ion
,RAB5A,SUN2,GLI3,TMED2,MCOLN1,SCFD1,VTI1B,SLC25A6,VAMP4,
MDFI,NUP85,HINFP,STAM2,VPS51,CANX,YIF1A,RPLP0,SDAD1,SNX2
7,KIF13B,RHBDF2,TLN1,NLGN2,TWF1,ATG4A,PDIA3,ATG16L2,SNX14
,LONP2,CSNK1E,ATG3,LMF1,SEC31B,SPCS3,SEPT2,PKD1,PDPK1,TS
G101,KPNA1,CD63,SCAMP1,UBR5,CLASP1,GORASP1
CDK14,RSPRY1,PLEKHA3,LPP,DHX34,CRIP2,ACADVL,EIF2B4,RAI1,C
KB,IGF1R,GK5,PTS,MYO1D,SIRT2,EPHX2,UTRN,MYNN,TARS,RAF1,N
LRP1,ZNF131,SEPT5,LEPRE1,COL9A1,CDK13,RBM6,ATP2B1,CPE,PL
CD1,COL2A1,RAB34,CALML4,ERCC6L2,MARCH5,BCL6,ZNF783,CMP
K2,ENOSF1,GBP3,SHMT2,ZFP91,EEF2K,NLN,PGS1,SMPD4,SMAD7,M
CF2L,USP4,HDAC6,ARHGEF12,EHMT1,VRK2,ZNF496,HGS,TYW1B,N
ARS,LANCL2,SYTL4,DGKA,PNKP,SUPT4H1,ZNF83,ITGA9,ARHGEF25,
ADAMTS1,RGL4,ZSCAN31,STARD9,CPM,FDPS,PAM,ABCC1,HSD17B
12,DDX23,MARK4,UHMK1,ADAM8,RNF220,RAB35,XAF1,PCGF6,RAN
BP1,MARCH6,DDX39A,SKIV2L,MINK1,PDLIM5,RNF24,RHOF,EEF1A1,
ACTR3,LHX4,CSNK2A1,NOD1,PRKACA,STAT2,DHX9,PLK1,ZNF446,P
NPO,LMAN2,PDE7B,ASNS,JAG2,DNM1L,UPF1,ZNF621,HDGF,FDXR,R
C3H1,PPP5C,PDXK,RHOBTB1,HERC2,CHD6,ZC3H12A,SEPT4,MIB2,P
OLM,EFTUD2,AAMP,RAB24,GCDH,PCGF1,CAMK2D,ZNF721,ZNF397,
JHDM1D,ZNF710,PLCB4,DNPEP,GALK2,TNK2,USP20,GIT2,FLG,STK4,
ZNF142,MTG1,RARS,ZNF540,ALDH18A1,MAN2C1,FGFR1,RAB18,MM
P16,NADSYN1,PMS1,ADCY4,PDE4D,SF3A2,TAB2,SGK1,PLEKHG4,SH
ARPIN,DPF2,CHKB,NADK,IDI1,RNF8,CYP2R1,MDM2,KCMF1,ZCCHC1
4,ZFYVE26,PRKCH,PPM1F,ZNF595,IDH3G,YY1,INO80,GMEB2,THBS3,
MCFD2,RALGPS2,NAGK,PLEKHG5,DDX58,ALDH6A1,ZCCHC9,LIMCH
1,MAGI1,ZEB1,NEK3,CRIP1,REPS1,TPM4,COL18A1,RTKN,EBF1,PHF1
5,FKBP10,UNKL,NPR1,ZNF3,RPS6KA5,G3BP1,RAB31,ALKBH3,NTPC
R,ZNF837,PKD2,RXRB,GALT,UBE2Q1,MDP1,PPP2R3C,ITGA3,ZZEF1,
LTBP4,RABGGTA,GNAI1,USP3,PLEKHA2,MZF1,ZFPM2,CPPED1,RNF
168,MARK3,PAFAH1B1,ZNF865,EDEM2,RNF217,SLFN11,TPP1,ACBD
4,SYTL2,CHMP1A,PDE8A,AACS,STK38L,DDX6,ACAP2,ZNF558,ANXA
5,GALNT2,ADAM15,USP33,ZNF263,ZNF180,ZNF276,NR1H3,GARS,CY
1.14
234
051
9
3.
8
2
E
0
5
G
O:
00
purine nucleoside binding
mol
ecul
ar_f
TH2,PLK2,NRP1,ZNF605,CHFR,ZNF410,PTGR2,TENC1,FMO2,GMDS,
RPL37A,MAST2,PTEN,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,IQGAP1,C1
R,IKBKB,PXN,ADAMTS18,KPNB1,PTPRF,ATP11B,PPP1R10,PARN,ZM
YM5,TNS1,FECH,ERAL1,STK19,NECAB3,PIAS2,CLSTN2,MAPK8,MYC
BP2,MYLK,DDX41,MAN1A2,RNF213,ZNF565,ABCA2,RAB8A,ZFAND2B
,TRIM28,DENND4C,MAP4K4,CSK,CP,ITPA,PTPRC,PSMC6,SWAP70,I
MPDH1,RNF146,SKIV2L2,CDK6,ABI3BP,AGBL5,EBF4,DDHD2,FARSA,
ZNF148,ZNF76,PSMC4,KIFC2,ARHGAP29,OGFOD3,UBA2,AAK1,SP11
0,PPA2,PHKG2,PAK1,PCDH7,RAB10,RHEB,ZSWIM7,TRPM7,IKZF5,CS
F1R,DGKZ,ACTR2,ZNF609,SMAD4,FNTB,CHURC1,CHURC1FNTB,ZNF114,TGFB1I1,DDAH1,LIMD2,DTYMK,MTRR,ZNF44,TANK,IN
G4,ZNF687,CLK3,NR2C2,LRPAP1,RAB5A,CA5B,BCS1L,C1S,ATP5A1,
GLI3,THNSL2,ADD3,NDUFV1,MAPK12,NDUFS2,RASGRF2,EPS15L1,A
K5,B4GALT4,SIRT7,ZSCAN5A,NOX4,ZNF692,ETFA,PHF1,NRBP2,B3G
AT3,STK36,SDHA,ATP8B2,ARHGEF7,DEF8,PHF12,ASAP1,CAPS2,UB
A6,RABGGTB,ZNF554,IDH3B,PTGR1,NUBP1,CIZ1,ITGA5,HINFP,MAN2
A2,LPCAT1,PDGFRB,DZIP1,RAD51B,CDK11A,MAN1B1,GLIS3,NOB1,E
NO4,MYO7B,FARP1,DBF4,RAP1B,CANX,RUNX1,MKNK2,TRIM41,SMA
RCA4,MFI2,DHX40,SUMF2,RAD54L2,ZNF518B,KIF13B,CLK4,ZNF90,Z
NF638,ZC4H2,FGF14,DOCK8,ADRBK2,PHC3,DNAJC21,LONRF3,GSK3
A,SIK3,ITGA11,ZNF383,EFCAB2,FPGS,SETD2,TWF1,PRPF4B,COL13A
1,PTGIS,WDFY3,MYO1E,D2HGDH,AMFR,NUCB1,MOB1A,PSTK,PHF2
1A,GPHN,ARL15,PGM2,ERI3,RGL2,CHD2,RABL3,LONP2,ZBED5,STAT
6,CARS2,PSD3,CSNK1E,SLC25A24,ZNF138,ZNF705A,CDK5RAP1,BNI
P2,NTRK1,SHPRH,PHKG1,CACNA2D1,SMAD9,HBB,TGFBR3,ZFC3H1,
CACNA2D4,LIMS2,ZBTB16,STAMBPL1,ZDHHC8,BAZ2A,SIRT3,PLOD2,
UCK1,EGFL8,VARS,LARS,PHF19,LMCD1,LETM1,DHX37,SEPT2,PDPK
1,THAP6,ZC3H14,DDAH2,ACAN,STK24,RAPGEF6,GAK,MTO1,MMP25,
RBKS,PANK3,UBR5,FASTK,EYA2,PHC2,SMARCAD1
CDK14,DHX34,EIF2B4,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,S
EPT5,CDK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,M
CF2L,ARHGEF12,VRK2,NARS,LANCL2,DGKA,PNKP,ARHGEF25,RGL4
1.30
234
194
3.
9
9
01
88
3
G
O:
00
32
54
9
unct
ion
ribonucleoside binding
mol
ecul
ar_f
unct
ion
,STARD9,ABCC1,DDX23,MARK4,UHMK1,RAB35,RANBP1,DDX39A,SKI
V2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PL
K1,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD
2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,ALDH18A1,FGFR1
,RAB18,NADSYN1,PMS1,ADCY4,SGK1,PLEKHG4,CHKB,NADK,PRKC
H,IDH3G,INO80,RALGPS2,NAGK,PLEKHG5,DDX58,MAGI1,NEK3,RTK
N,NPR1,RPS6KA5,G3BP1,RAB31,NTPCR,UBE2Q1,GNAI1,MARK3,SLF
N11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,MAST2,FYN,SRPK1,RU
NX2,IKBKB,ATP11B,ERAL1,STK19,MAPK8,MYLK,DDX41,RNF213,ABC
A2,RAB8A,DENND4C,MAP4K4,CSK,PSMC6,SWAP70,SKIV2L2,CDK6,F
ARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,PAK1,RAB10,RHEB,TRPM7,
CSF1R,DGKZ,ACTR2,DTYMK,CLK3,RAB5A,BCS1L,ATP5A1,MAPK12,R
ASGRF2,AK5,NRBP2,STK36,ATP8B2,ARHGEF7,UBA6,NUBP1,PDGFR
B,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RUNX1,MKNK2,SMARCA4,
DHX40,RAD54L2,KIF13B,CLK4,DOCK8,ADRBK2,GSK3A,SIK3,FPGS,T
WF1,PRPF4B,MYO1E,PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP2,
CARS2,PSD3,CSNK1E,NTRK1,SHPRH,PHKG1,UCK1,VARS,LARS,DH
X37,SEPT2,PDPK1,STK24,RAPGEF6,GAK,RBKS,PANK3,FASTK,SMAR
CAD1,WNK1,DENND6B
CDK14,DHX34,EIF2B4,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,S
EPT5,CDK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,M
CF2L,ARHGEF12,VRK2,NARS,LANCL2,DGKA,PNKP,ARHGEF25,RGL4
,STARD9,ABCC1,DDX23,MARK4,UHMK1,RAB35,RANBP1,DDX39A,SKI
V2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PL
K1,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD
2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,ALDH18A1,FGFR1
,RAB18,NADSYN1,PMS1,ADCY4,SGK1,PLEKHG4,CHKB,NADK,PRKC
H,IDH3G,INO80,RALGPS2,NAGK,PLEKHG5,DDX58,MAGI1,NEK3,RTK
N,NPR1,RPS6KA5,G3BP1,RAB31,NTPCR,UBE2Q1,GNAI1,MARK3,SLF
N11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,MAST2,FYN,SRPK1,RU
NX2,IKBKB,ATP11B,ERAL1,STK19,MAPK8,MYLK,DDX41,RNF213,ABC
A2,RAB8A,DENND4C,MAP4K4,CSK,PSMC6,SWAP70,SKIV2L2,CDK6,F
5
1.30
169
497
9
E
0
5
4.
1
1
E
0
5
ARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,PAK1,RAB10,RHEB,TRPM7,
CSF1R,DGKZ,ACTR2,DTYMK,CLK3,RAB5A,BCS1L,ATP5A1,MAPK12,R
ASGRF2,AK5,NRBP2,STK36,ATP8B2,ARHGEF7,UBA6,NUBP1,PDGFR
B,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RUNX1,MKNK2,SMARCA4,
DHX40,RAD54L2,KIF13B,CLK4,DOCK8,ADRBK2,GSK3A,SIK3,FPGS,T
WF1,PRPF4B,MYO1E,PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP2,
CARS2,PSD3,CSNK1E,NTRK1,SHPRH,PHKG1,UCK1,VARS,LARS,DH
X37,SEPT2,PDPK1,STK24,RAPGEF6,GAK,RBKS,PANK3,FASTK,SMAR
CAD1,WNK1,DENND6B
G
O:
00
31
25
2
G
O:
00
05
52
4
cell leading edge
ATP binding
cell
ular
_co
mpo
nent
FZD6,MYO1D,RAB34,DPP4,MCF2L,HDAC6,CAPZB,ACTR3,VASP,TLN
2,DDX58,PTPRK,PKD2,MAPK8IP3,PAFAH1B1,ARPC2,MTMR14,FAP,IQ
GAP1,PXN,SRGAP2,ITGB5,MYLK,SWAP70,CDK6,AAK1,PAK1,TRPM7,
DGKZ,EZR,RAB5A,ARHGEF7,CTTN,ITGA5,TLN1,TWF1,ROBO2,SSH1
mol
ecul
ar_f
unct
ion
CDK14,DHX34,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,CDK13,A
TP2B1,ERCC6L2,CMPK2,EEF2K,PGS1,VRK2,NARS,LANCL2,DGKA,P
NKP,STARD9,ABCC1,DDX23,MARK4,UHMK1,DDX39A,SKIV2L,MINK1,
ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PLK1,ASNS,UPF1,PDXK,CHD
6,CAMK2D,GALK2,TNK2,STK4,RARS,ALDH18A1,FGFR1,NADSYN1,P
MS1,ADCY4,SGK1,CHKB,NADK,PRKCH,IDH3G,INO80,NAGK,DDX58,
MAGI1,NEK3,NPR1,RPS6KA5,G3BP1,NTPCR,UBE2Q1,MARK3,SLFN1
1,AACS,STK38L,DDX6,GARS,PLK2,MAST2,FYN,SRPK1,RUNX2,IKBKB
,ATP11B,STK19,MAPK8,MYLK,DDX41,RNF213,ABCA2,MAP4K4,CSK,P
SMC6,SWAP70,SKIV2L2,CDK6,FARSA,PSMC4,KIFC2,UBA2,AAK1,PH
KG2,PAK1,TRPM7,CSF1R,DGKZ,ACTR2,DTYMK,CLK3,BCS1L,ATP5A1
,MAPK12,AK5,NRBP2,STK36,ATP8B2,UBA6,NUBP1,PDGFRB,RAD51B
,CDK11A,MYO7B,RUNX1,MKNK2,SMARCA4,DHX40,RAD54L2,KIF13B,
CLK4,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO1E,PSTK,GPH
N,CHD2,LONP2,CARS2,CSNK1E,NTRK1,SHPRH,PHKG1,UCK1,VARS,
LARS,DHX37,PDPK1,STK24,GAK,RBKS,PANK3,FASTK,SMARCAD1,W
1.97
675
262
2
4.
2
1
E
0
5
1.36
072
188
3
4.
4
5
E
0
5
NK1
G
O:
00
00
90
2
G
O:
00
10
46
7
cell morphogenesis
gene expression
FZD6,CADM1,PSMB10,IGF1R,LAMB1,NPHP3,RAF1,COL9A1,BDNF,CO
L2A1,BCL6,SMAD7,ARHGEF12,CD72,TTLL3,LEF1,PAX8,ITGA9,ADAM
8,CAPZB,PRPF40A,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,CSNK
2A1,SLC11A2,CNP,BBS1,STK4,FGFR1,CAPRIN1,KIAA0586,SSH2,CRE
biol
B1,RGMB,COL18A1,RPS6KA5,RB1,MAPK8IP3,PAFAH1B1,ARPC2,ADA
ogic
M15,USP33,HEXA,NRP1,PTEN,FYN,IFT172,SRGAP2,MEF2A,TCTN1,C
al_p
ACNB1,MYCBP2,RAB8A,TRIM28,COL9A3,PTPRC,FLOT1,RANBP9,WD
roce
R35,PAK1,NCK2,RAB10,SEMA6A,SEMA4D,CSF1R,ROBO3,SS18,SMA
ss
D4,TGFB1I1,EZR,FLNA,GLI3,NOX4,EXT1,STK36,TBCE,ASAP1,UNC5B,
PTPRD,ITGA5,DZIP1,CC2D2A,FARP1,SMARCA4,KIF13B,PTPN23,TLN
1,TROVE2,ROBO2,CACNB3,CLIC4,NTRK1,BRWD1,TGFBR3,TMEM237
,SEPT2,FOXC1,STK24,SSH1,C2CD3,CLASP1
FZD6,PBX2,KANK2,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,TNRC6A,SIR
T2,EPHX2,MYNN,TRNAU1AP,NOC2L,TARS,ZNF131,RSC1A1,SFSWAP
,CDK13,RBM6,SIN3B,CPE,CBX5,SART1,COL2A1,SUPT5H,PWP1,BCL6
,FUBP1,ZNF783,TBX2,MMS19,EEF2K,CUX1,RBM17,CLNS1A,EED,FM
R1,SMAD7,MCF2L,USP4,HDAC6,GLG1,EHMT1,ZNF496,TYW1B,NARS,
LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,RBPMS,ZSCAN31
,XBP1,PAM,SNRNP70,DDX23,METTL3,APITD1,UHMK1,USP47,ADAM8
biol
,NOL3,POLR3E,GABPB1,PRPF40A,PCGF6,DDX39A,SUGP1,EEF1A1,L
ogic
HX4,CSNK2A1,IGBP1,UPF3A,NOD1,STAT2,RPP14,DHX9,PLK1,ZNF44
al_p
6,PTGES2,UPF1,ZNF621,HDGF,RC3H1,PPP5C,CCNL1,CHD6,ZC3H12
roce
A,SYMPK,EFTUD2,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721
ss
,ZNF397,JHDM1D,ZNF710,GIGYF2,PRPF3,WAC,ZNF142,FUBP3,RARS
,ZNF540,FGFR1,HPS4,HSF4,C2,CFB,DISP1,PAIP1,CAPRIN1,GTF3C1,
CELF1,SF3A2,PAF1,TAB2,SGK1,DPF2,RNF8,MDM2,RHBDD1,FKBP1A,
PRKCH,PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,SRP9,
FLII,RPRD1A,DDX58,RPL27,CCNL2,PTPRK,SERPINH1,ZEB1,EIF4B,C
RIP1,SERBP1,ASCC2,RGMB,EBF1,RPL9,MED28,ZNF3,RPS6KA5,NIPB
L,ALKBH3,BRD9,ZNF837,PKD2,CASP2,HNRNPA3,RXRB,LMNA,RSL1D
1.45
988
277
8
4.
5
7
E
0
5
1.17
564
300
2
4.
5
8
E
0
5
1,MITF,NOL8,RB1,PRMT5,MAPK8IP3,USP3,MZF1,ZFPM2,TP53BP1,R
NF168,ZNF865,SENP2,IL18,PUM2,SUB1,CHMP1A,PDE8A,NSA2,DDX6
,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GARS,MRPS7,PAN2,
USP7,PLD6,FLCN,ZNF605,ZNF410,RPL24,RPL37A,SAP30BP,VPS72,P
TEN,FYN,SRPK1,RNASEK,RUNX2,CSTF1,FBXW7,INTS4,SMARCD3,IF
T172,IKBKB,RQCD1,RFX7,NCOR1,PPP1R10,MEF2A,PARN,FECH,SET
D8,PIAS2,MAPK8,MYCBP2,UPK3B,USP15,DDX41,SRRM2,PBX3,ZNF5
65,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,PSMC6,UBP1,SKIV2L2,C
DK6,WDR61,EBF4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,AA
K1,SP110,PPA2,NCK2,HNRNPH3,CTSH,ZSWIM7,TCF4,IKZF5,HMGN2,
WDR4,SEMA4D,SSBP2,ERC1,C3,NFYC,PIWIL4,SRSF10,SS18,RCOR3
,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,INO80E,RPL4,ZNF44,CREBZ
F,ING4,RBMS1,EIF3M,ZNF687,CLK3,NR2C2,FHOD1,FIP1L1,DNTTIP2,
MRPL49,FLNA,IRF9,GLI3,TMED2,MAPK12,CCDC59,DCAF6,THOC2,EN
G,SIRT7,ZSCAN5A,TCF12,PCSK7,ARNT,ZNF692,GAPDH,PHF1,MTRF
1L,STK36,WWP1,PHF12,TBCE,MED6,MDFI,CIRBP,ZNF554,RGS2,HIN
FP,NCBP2,MLX,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,MKNK2,SM
ARCA4,NAA16,LRPPRC,RPLP0,CLASRP,ZNF518B,CRCP,CLK4,ZNF90
,ZNF638,PER3,SNRPE,ZNF383,MRPL3,POLR2J3,NCOR2,SETD2,PRP
F4B,IGF2,PTGIS,FTSJ3,TROVE2,ATXN3,PSTK,PHF21A,PDCD4,SOX1
3,CHD2,LONP2,PSMA1,STAT6,CARS2,SON,ZNF138,ZNF705A,CDK5R
AP1,NTRK1,TFAM,BRWD1,SMAD9,LMF1,TGFBR3,ZFC3H1,ZBTB16,B
AZ2A,SPCS3,EIF3I,RRP8,VARS,LARS,PHF19,LMCD1,LUC7L3,PKD1,P
DPK1,TSG101,USF1,FOXC1,ARL6IP4,HEMK1,CDK5RAP3,C2CD3,MTO
1,PABPC1,FASTK,EYA2,SMARCAD1,CC2D1A,GATA2,PABPN1
G
O:
00
06
66
2
glycerol ether metabolic process
biol
ogic
al_p DNAJC10,TXNL1,QSOX1,TXNDC5,P4HB,PDIA5,PDIA3
roce
ss
6.28
722
849
7
4.
6
1
E
0
5
G
O:
00
06
72
5
cellular aromatic compound metabolic
process
FZD6,USP10,RNASEH2B,CRBN,OBFC1,RAB3GAP2,PBX2,DHX34,KAN
K2,ACADVL,EIF2B4,GTF3C2,RAI1,PSMB10,XRN1,IGF1R,PTS,MYO1D,
SIRT2,EPHX2,RALGAPA2,MYNN,NOC2L,TARS,RAF1,ZNF131,SEPT5,
RSC1A1,SFSWAP,CDK13,RBM6,SIN3B,ATP2B1,CBX5,SART1,RAB34,
SUPT5H,SUPT20H,PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,
GBP3,SHMT2,VAPB,CUX1,RBM17,CLNS1A,NUP98,EED,SMAD7,MCF2
L,PPFIBP2,HDAC6,ARHGEF12,EHMT1,ATP6V1D,RNH1,ZNF496,TYW1
B,NARS,LANCL2,H6PD,PNKP,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,E
MX2,ARHGEF25,RGL4,RBPMS,STARD13,ZSCAN31,XBP1,PAM,ABCC
1,NOM1,SNRNP70,DDX23,RAD23A,METTL3,APITD1,USP47,ADAM8,N
OL3,POLR3E,GABPB1,PRPF40A,DNAJC10,RAB35,PCGF6,RANBP1,SI
PA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,SUGP1,EEF1A1,LHX4,CS
NK2A1,IGBP1,UPF3A,NOD1,STAT2,RPP14,DHX9,PLK1,ZNF446,PDE7
biol B,ASNS,TBC1D2B,DNM1L,PTGES2,UPF1,ZNF621,HDGF,FDXR,RC3H
ogic 1,PPP5C,CCNL1,HERC2,CHD6,ZC3H12A,TBC1D10B,SEPT4,POLM,SL
al_p C11A2,SYMPK,EFTUD2,FAM58A,CNP,TBX18,GCDH,LBX2,PCGF1,DR
roce 1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,TBC1D14,PRPF3,TNK2,G
ss
IT2,WAC,ZNF142,FUBP3,MTG1,RARS,ZNF540,FGFR1,RAB18,HSF4,P
AIP1,GTF3C1,ERH,NADSYN1,PMS1,ADCY4,CELF1,SNCAIP,PDE4D,R
NASET2,SF3A2,PAF1,TAB2,SGK1,PLEKHG4,DPF2,NADK,RNF8,SEC3
1A,MDM2,ZFYVE26,PRKCH,PPM1F,ZNF595,TBP,DIS3L,YY1,FAM13A,I
NO80,GMEB2,PFDN5,CREB1,RALGPS2,FLII,PLEKHG5,RPRD1A,DDX5
8,ALDH6A1,RPL27,CCNL2,PTPRK,SNX13,NF1,ZEB1,EIF4B,IFITM3,AS
CC2,RGMB,RTKN,EBF1,RPL9,MED28,NPR1,ZNF3,RPS6KA5,G3BP1,N
IPBL,RAB31,ALKBH3,ADSL,BRD9,ZNF837,PKD2,HNRNPA3,RXRB,GA
LT,LMNA,MITF,NOL8,RB1,PRMT5,GNAI1,USP3,MZF1,ZFPM2,TP53BP
1,RNF168,PAFAH1B1,ZNF865,SENP2,TPP1,SUB1,CHMP1A,PDE8A,N
SA2,DDX6,ACAP2,ZNF558,MUM1,ZNF263,ZNF180,BICD1,ZNF276,RG
S3,NR1H3,GARS,CYTH2,PAN2,USP7,PLD6,FLCN,CUL4A,ZNF605,ZNF
410,FMO2,GMDS,RPL24,ARHGAP9,RPL37A,SAP30BP,VPS72,PTEN,I
DH1,SRPK1,RNASEK,RUNX2,CSTF1,IQGAP1,FBXW7,INTS4,SMARCD
1.13
881
046
6
4.
6
4
E
0
5
G
O:
00
32
99
0
cell part morphogenesis
3,HERPUD1,IKBKB,CTNS,RQCD1,KPNB1,SRGAP2,RFX7,NCOR1,ATP
11B,PPP1R10,MEF2A,PARN,FECH,SETD8,PIAS2,SSBP1,MAPK8,MYC
BP2,USP15,DDX41,SRRM2,PBX3,RNF213,ZNF565,ABCA2,AFF4,TRIM
28,DENND4C,DMTF1,MAP4K4,CDK5RAP2,ITPA,PTPRC,PSMC6,SWA
P70,TBCD,IMPDH1,UBP1,SKIV2L2,WDR61,EBF4,PRPF8,FARSA,ZNF1
48,ZNF76,PSMC4,HNRNPL,ARHGAP29,SGSM3,STAG2,SP110,GOPC,
PPA2,NCK2,RHEB,HNRNPH3,ZSWIM7,TCF4,ACD,IKZF5,HMGN2,WDR
4,SEMA4D,GNB3,SSBP2,ERC1,NFYC,PIWIL4,RPUSD4,SRSF10,SS18,
RCOR3,SMAD4,GRPEL2,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF4
4,CREBZF,ING4,RBMS1,ZNF687,CDC14B,CLK3,SLC23A2,NR2C2,FHO
D1,FIP1L1,DNTTIP2,FLNA,RAB5A,IRF9,ATP5A1,GLI3,TMED2,MAPK12,
CCDC59,DCAF6,RASGRF2,AK5,THOC2,ENG,SIRT7,ZSCAN5A,TCF12,
ARNT,NOX4,ZNF692,ERCC1,PHF1,STK36,WWP1,ATP8B2,ARHGEF7,
PHF12,PDIA5,ASAP1,REXO2,MED6,MDFI,ZNF554,IDH3B,NAA10,CIZ1,
RGS2,HINFP,NCBP2,MLX,PDGFRB,TGS1,NCAPD3,RAD51B,CDK11A,
GLIS3,ELP6,BDP1,FARP1,DBF4,RAP1B,RUNX1,SMARCA4,NAA16,LR
PPRC,YIF1A,RPLP0,DHX40,RAD54L2,CLASRP,ZNF518B,CRCP,CLK4,
ZNF90,ZNF638,PER3,TLN1,DOCK8,CHTF8,LONRF3,GSK3A,SNRPE,P
OLG,ZNF383,POLR2J3,NCOR2,FPGS,SETD2,PRPF4B,IGF2,PTGIS,FT
SJ3,TROVE2,MYO1E,ATXN3,PSTK,PHF21A,PDCD4,SOX13,ERI3,RGL
2,CHD2,LONP2,PSMA1,STAT6,CARS2,ACIN1,PSD3,CSNK1E,SON,ZN
F138,ZNF705A,CDK5RAP1,NSMCE4A,BNIP2,NTRK1,TFAM,SHPRH,BR
WD1,SMAD9,TGFBR3,ZFC3H1,ZBTB16,BAZ2A,UCK1,RRP8,VARS,LA
RS,PHF19,LMCD1,DHX37,LUC7L3,PKD1,PDPK1,TSG101
FZD6,IGF1R,LAMB1,NPHP3,RAF1,COL9A1,BDNF,COL2A1,ARHGEF12
biol ,CD72,TTLL3,ITGA9,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,CSN
ogic K2A1,DNM1L,SLC11A2,CNP,BBS1,FGFR1,CAPRIN1,KIAA0586,SSH2,
al_p CREB1,RGMB,RPS6KA5,MAPK8IP3,PAFAH1B1,USP33,NRP1,PTEN,F
roce YN,IFT172,SRGAP2,MEF2A,TCTN1,SSBP1,CACNB1,MYCBP2,RAB8A,
ss
COL9A3,PTPRC,FLOT1,RANBP9,WDR35,PAK1,NCK2,RAB10,SEMA6A
,SEMA4D,ROBO3,EZR,FLNA,GLI3,EXT1,STK36,TBCE,ASAP1,UNC5B,
1.55
011
822
7
4.
7
1
E
0
5
G
O:
00
32
55
5
G
O:
00
70
64
7
purine ribonucleotide binding
protein modification by small protein
conjugation or removal
PTPRD,ITGA5,DZIP1,CC2D2A,FARP1,KIF13B,PTPN23,TLN1,TROVE2,
ROBO2,CACNB3,NTRK1,TMEM237,SEPT2,STK24,SSH1,C2CD3,CLAS
P1
CDK14,DHX34,EIF2B4,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,S
EPT5,CDK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,M
CF2L,ARHGEF12,VRK2,NARS,LANCL2,DGKA,PNKP,ARHGEF25,RGL4
,STARD9,ABCC1,DDX23,MARK4,UHMK1,RAB35,RANBP1,DDX39A,SKI
V2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PL
K1,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD
2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,ALDH18A1,FGFR1
,RAB18,NADSYN1,PMS1,ADCY4,PDE4D,SGK1,PLEKHG4,CHKB,NADK
,PRKCH,IDH3G,INO80,RALGPS2,NAGK,PLEKHG5,DDX58,MAGI1,NEK
mol
3,RTKN,NPR1,RPS6KA5,G3BP1,RAB31,NTPCR,UBE2Q1,GNAI1,MARK 1.29
ecul
3,SLFN11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,MAST2,FYN,SRPK 553
ar_f
1,RUNX2,IKBKB,ATP11B,ERAL1,STK19,MAPK8,MYLK,DDX41,RNF213, 308
unct
ABCA2,RAB8A,DENND4C,MAP4K4,CSK,PSMC6,SWAP70,SKIV2L2,CD
2
ion
K6,FARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,PAK1,RAB10,RHEB,TRP
M7,CSF1R,DGKZ,ACTR2,DTYMK,CLK3,RAB5A,BCS1L,ATP5A1,MAPK
12,RASGRF2,AK5,NRBP2,STK36,ATP8B2,ARHGEF7,UBA6,NUBP1,PD
GFRB,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RUNX1,MKNK2,SMAR
CA4,DHX40,RAD54L2,KIF13B,CLK4,DOCK8,ADRBK2,GSK3A,SIK3,FP
GS,TWF1,PRPF4B,MYO1E,PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,L
ONP2,CARS2,PSD3,CSNK1E,NTRK1,SHPRH,PHKG1,UCK1,VARS,LAR
S,DHX37,SEPT2,PDPK1,STK24,RAPGEF6,GAK,RBKS,PANK3,FASTK,
SMARCAD1,WNK1,DENND6B
USP10,CRBN,PSMB10,PPIL2,SPOP,MARCH5,UBXN1,FBXO32,ZFP91,
biol SMAD7,USP4,HDAC6,PSMB9,APITD1,USP47,RNF220,MARCH6,ANAP
1.54
ogic C4,PLK1,RC3H1,HERC2,SEPT4,MIB2,PCGF1,USP20,DCAF11,WAC,C
857
al_p OPS7B,PAF1,SHARPIN,RNF8,MDM2,FKBP1A,ANAPC16,NUB1,SPSB3,
844
roce UNKL,DCAF8,UBE2Q1,UBAC1,USP3,RNF168,SENP2,RNF217,USP33,
8
ss
USP7,CUL4A,CHFR,PTEN,FBXW7,HERPUD1,PIAS2,MYCBP2,USP15,
RNF213,TRIM28,PSMC6,RNF146,PSMC4,UBA2,OS9,ASB8,CDCA3,CD
5.
1
8
E
0
5
5.
4
3
E
0
5
G
O:
00
01
88
2
G
O:
00
16
60
7
C14B,DCAF6,ARNT,WWP1,UBA6,TRIM41,DCAF17,KLHL7,FBXW2,ATX
N3,AMFR,PSMA1,SHPRH,ATG3,ZBTB16,SENP6,UBR5
CDK14,DHX34,EIF2B4,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,S
EPT5,CDK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,M
CF2L,ARHGEF12,VRK2,NARS,LANCL2,DGKA,PNKP,ARHGEF25,RGL4
,STARD9,ABCC1,DDX23,MARK4,UHMK1,RAB35,RANBP1,DDX39A,SKI
V2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PL
K1,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,HERC2,CHD6,SEPT4,EFTUD
2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,ALDH18A1,FGFR1
,RAB18,NADSYN1,PMS1,ADCY4,SGK1,PLEKHG4,CHKB,NADK,PRKC
H,IDH3G,INO80,RALGPS2,NAGK,PLEKHG5,DDX58,MAGI1,NEK3,RTK
N,NPR1,RPS6KA5,G3BP1,RAB31,NTPCR,UBE2Q1,GNAI1,MARK3,SLF
N11,AACS,STK38L,DDX6,GARS,CYTH2,PLK2,MAST2,FYN,SRPK1,RU
NX2,IKBKB,ATP11B,ERAL1,STK19,MAPK8,MYLK,DDX41,RNF213,ABC
A2,RAB8A,DENND4C,MAP4K4,CSK,PSMC6,SWAP70,SKIV2L2,CDK6,F
ARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,PAK1,RAB10,RHEB,TRPM7,
CSF1R,DGKZ,ACTR2,DTYMK,CLK3,RAB5A,BCS1L,ATP5A1,MAPK12,R
ASGRF2,AK5,NRBP2,STK36,ATP8B2,ARHGEF7,UBA6,NUBP1,PDGFR
B,RAD51B,CDK11A,MYO7B,FARP1,RAP1B,RUNX1,MKNK2,SMARCA4,
DHX40,RAD54L2,KIF13B,CLK4,DOCK8,ADRBK2,GSK3A,SIK3,FPGS,T
WF1,PRPF4B,MYO1E,PSTK,GPHN,ARL15,RGL2,CHD2,RABL3,LONP2,
CARS2,PSD3,CSNK1E,NTRK1,SHPRH,PHKG1,UCK1,VARS,LARS,DH
X37,SEPT2,PDPK1,STK24,RAPGEF6,GAK,RBKS,PANK3,FASTK,SMAR
CAD1,WNK1,DENND6B
nucleoside binding
mol
ecul
ar_f
unct
ion
nuclear speck
cell
ular CDK13,SNRNP70,METTL3,PRPF40A,CCNL1,EFTUD2,FYTTD1,PRPF3,
_co WAC,CCNL2,PIAS2,SRRM2,PRPF8,ATPAF2,TIMM50,SRSF10,CLK3,FA
mpo M76B,ZNF638,ACIN1,SON,PNISR,ZBTB16,LUC7L3,ZC3H14
nent
1.29
526
050
1
5.
5
0
E
0
5
2.33
222
129
6
5.
9
4
E
0
5
G
O:
00
51
60
3
G
O:
00
16
77
3
G
O:
00
30
55
4
proteolysis involved in cellular protein
catabolic process
biol
ogic
al_p
roce
ss
phosphotransferase activity, alcohol group
as acceptor
mol
ecul
ar_f
unct
ion
adenyl nucleotide binding
mol
ecul
ar_f
unct
ion
USP10,CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,USP4,HDAC6,DE
RL2,PSMB9,RAD23A,USP47,DNAJC10,PRKACA,ANAPC4,PLK1,HERC
2,USP20,WAC,RNF8,MDM2,RHBDD1,RHBDF1,NUB1,USP24,USP3,RN
F168,RNF217,USP33,PAN2,USP7,CUL4A,CHFR,PTEN,FBXW7,HERPU
D1,USP15,PSMC6,RNF146,PSMC4,OS9,TGFB1I1,USP54,WWP1,UBA6
,MAN1B1,USP40,ATXN3,AMFR,LONP2,PSMA1,CSNK1E,TSG101,UBR
5
CDK14,ACADVL,IGF1R,GK5,RAF1,CDK13,ZFP91,EEF2K,VAPB,VRK2,
DGKA,PNKP,XBP1,MARK4,UHMK1,ADAM8,MINK1,PTPN6,CSNK2A1,N
OD1,PRKACA,PLK1,ASNS,HDGF,PDXK,CCNL1,FAM58A,CAMK2D,GA
LK2,TNK2,STK4,FGFR1,ADCY4,TAB2,SGK1,CHKB,NADK,SEC31A,FK
BP1A,PRKCH,PPM1F,NAGK,CCNL2,NF1,NEK3,NPR1,RPS6KA5,PKD2,
LMNA,RB1,LTBP4,MAPK8IP3,MARK3,TPP1,STK38L,SH3BP5,RGS3,PL
K2,NRP1,MAST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,HERPUD1,IKBKB
,PXN,PRKRIP1,STK19,MAPK8,MYLK,TRIM28,MAP4K4,CSK,PTPRC,CD
K6,AAK1,PHKG2,PAK1,NCK2,TRPM7,CSF1R,DGKZ,CLK3,MAPK12,AK
5,ENG,NOX4,NRBP2,STK36,PDIA5,MDFI,RGS2,PDGFRB,CDK11A,CA
RD14,MKNK2,YIF1A,CLK4,TLN1,ADRBK2,GSK3A,SIK3,TWF1,PRPF4B,
IGF2,PDCD4,CRIPAK,CSNK1E,CDK5RAP1,NTRK1,SPRED1,TNFRSF1
0B,PHKG1,DUSP6,TGFBR3,UCK1,PKD1,PDPK1,STK24,CDK5RAP3,G
AK,RBKS,PANK3,FASTK,WNK1
CDK14,DHX34,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,CDK13,A
TP2B1,ERCC6L2,CMPK2,EEF2K,PGS1,VRK2,NARS,LANCL2,DGKA,P
NKP,STARD9,ABCC1,DDX23,MARK4,UHMK1,DDX39A,SKIV2L,MINK1,
ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PLK1,ASNS,UPF1,PDXK,CHD
6,CAMK2D,GALK2,TNK2,STK4,RARS,ALDH18A1,FGFR1,NADSYN1,P
MS1,ADCY4,PDE4D,SGK1,CHKB,NADK,PRKCH,IDH3G,INO80,NAGK,
DDX58,MAGI1,NEK3,NPR1,RPS6KA5,G3BP1,NTPCR,UBE2Q1,MARK3,
SLFN11,AACS,STK38L,DDX6,GARS,PLK2,MAST2,FYN,SRPK1,RUNX2
,IKBKB,ATP11B,STK19,MAPK8,MYLK,DDX41,RNF213,ABCA2,MAP4K4
,CSK,PSMC6,SWAP70,SKIV2L2,CDK6,FARSA,PSMC4,KIFC2,UBA2,AA
K1,PHKG2,PAK1,TRPM7,CSF1R,DGKZ,ACTR2,GRPEL2,DTYMK,CLK3,
1.71
130
435
8
6.
0
7
E
0
5
1.39
346
781
6
6.
0
7
E
0
5
1.34
888
967
6
6.
1
1
E
0
5
G
O:
00
04
67
4
protein serine/threonine kinase activity
G
O:
00
44
43
2
endoplasmic reticulum part
G
O:
organic cyclic compound binding
BCS1L,ATP5A1,MAPK12,AK5,NRBP2,STK36,ATP8B2,UBA6,NUBP1,PD
GFRB,RAD51B,CDK11A,MYO7B,RUNX1,MKNK2,SMARCA4,DHX40,RA
D54L2,KIF13B,CLK4,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO
1E,PSTK,GPHN,CHD2,LONP2,CARS2,CSNK1E,NTRK1,SHPRH,PHKG
1,UCK1,VARS,LARS,DHX37,PDPK1,STK24,GAK,RBKS,PANK3,FASTK,
SMARCAD1,WNK1
CDK14,IGF1R,RAF1,CDK13,ZFP91,EEF2K,VRK2,MARK4,UHMK1,ADA
M8,MINK1,PTPN6,CSNK2A1,NOD1,PRKACA,PLK1,CCNL1,FAM58A,CA
MK2D,TNK2,STK4,FGFR1,TAB2,SGK1,FKBP1A,PRKCH,CCNL2,NF1,N
mol
EK3,RPS6KA5,PKD2,LTBP4,MAPK8IP3,MARK3,STK38L,RGS3,PLK2,M
ecul
AST2,PTEN,SRPK1,IKBKB,PXN,STK19,MAPK8,MYLK,MAP4K4,CSK,PT
ar_f
PRC,CDK6,AAK1,PHKG2,PAK1,TRPM7,CSF1R,CLK3,MAPK12,AK5,EN
unct
G,NOX4,STK36,MDFI,RGS2,PDGFRB,CDK11A,CARD14,MKNK2,CLK4,
ion
ADRBK2,GSK3A,SIK3,PRPF4B,IGF2,PDCD4,CSNK1E,CDK5RAP1,NTR
K1,SPRED1,TNFRSF10B,PHKG1,DUSP6,TGFBR3,PKD1,PDPK1,STK2
4,CDK5RAP3,GAK,FASTK,WNK1
LEPRE1,COL9A1,COL2A1,HLADPB1,MARCH5,UBXN1,PLD1,VAPB,GPAA1,SMPD4,VRK2,DERL2,IL15
RA,H6PD,HLA-C,XYLT1,HSD17B12,HLADQA1,MPDU1,DNAJC10,MARCH6,PIGS,LMAN2,COL16A1,PIGG,SHIS
A5,NUP210,CLN8,PIGN,VAMP7,CAMK2D,COL14A1,RNASET2,SGK1,C
cell
YP2R1,SEC31A,RHBDD1,COL12A1,FKBP1A,SRP9,RHBDF1,SERPINH
ular
1,EMC3,COL18A1,FKBP10,ALG6,PKD2,TXNDC5,EDEM2,FMO2,HERP
_co
UD1,TMEM189,NECAB3,CLSTN2,OSBPL3,HLAmpo
F,COL9A3,TMEM66,STX18,EMC4,RAB10,OS9,P4HB,ELOVL1,TMED3,
nent
SLC39A7,MBOAT2,AUP1,LRPAP1,TMED2,RASGRF2,SCFD1,NOX4,EX
T1,PDIA5,LPCAT1,COL8A1,EBPL,MAN1B1,CANX,YIF1A,SUMF2,RHBD
F2,PAPPAAS1,PCYT1A,PIGO,PDIA3,COL13A1,PTGIS,AMFR,LMF1,SEC31B,PLO
D2,KDELC2,SPCS3,CES2,ALG9
mol CDK14,OBFC1,PBX2,DHX34,ACADVL,EIF2B4,GTF3C2,XRN1,CKB,IGF
ecul 1R,GK5,TNRC6A,MYO1D,SIRT2,MYNN,TRNAU1AP,TARS,RAF1,NLRP
1.50
455
079
8
6.
5
4
E
0
5
1.47
378
153
5
6.
5
7
E
0
5
1.14
431
6.
5
00
97
15
9
ar_f
unct
ion
1,ZNF131,SEPT5,SFSWAP,CDK13,RBM6,ATP2B1,RAB34,ERCC6L2,B
CL6,FUBP1,ZNF783,CMPK2,TBX2,GBP3,ZFP91,EEF2K,CUX1,PGS1,R
BM17,SLC9B2,FMR1,SMAD7,MCF2L,PPFIBP2,ARHGEF12,VRK2,ZNF4
96,TYW1B,NARS,LANCL2,H6PD,DGKA,PNKP,LEF1,PAX8,ZNF83,EMX
2,ARHGEF25,RGL4,RBPMS,ZSCAN31,STARD9,XBP1,ABCC1,NOM1,S
NRNP70,HSD17B12,DDX23,RAD23A,METTL3,APITD1,MARK4,UHMK1,
NOL3,GABPB1,RAB35,PCGF6,RANBP1,DDX39A,SKIV2L,MINK1,RHOF
,SUGP1,EEF1A1,ACTR3,LHX4,CSNK2A1,UPF3A,NOD1,PRKACA,STAT
2,RPP14,DHX9,PLK1,ZNF446,PNPO,ASNS,DNM1L,PTGES2,TNRC18,
UPF1,ZNF621,HDGF,FDXR,RC3H1,PDXK,NPC1,RHOBTB1,HERC2,CH
D6,SEPT4,POLM,EFTUD2,RAB24,CNP,TBX18,GCDH,LBX2,DR1,BCLA
F1,CAMK2D,FYTTD1,ZNF721,ZNF397,ZNF710,DHRSX,GALK2,PRPF3,
TNK2,STK4,ZNF142,FUBP3,MTG1,RARS,ZNF540,ALDH18A1,FGFR1,R
AB18,HSF4,PAIP1,CAPRIN1,GTF3C1,NADSYN1,PMS1,ADCY4,CELF1,
PDE4D,RNASET2,SF3A2,SGK1,PLEKHG4,CHKB,NADK,CYP2R1,FKBP
1A,ZCCHC14,PRKCH,DAZAP1,ZNF595,TBP,DIS3L,IDH3G,YY1,INO80,
GMEB2,SSH2,CREB1,SRP9,RALGPS2,NAGK,PLEKHG5,DDX58,ZCCH
C9,FAM114A2,MAGI1,ZEB1,NEK3,EIF4B,CRIP1,SERBP1,SETBP1,RTK
N,EBF1,RPL9,FKBP10,UNKL,NPR1,ZNF3,RPS6KA5,G3BP1,RAB31,BR
D9,NTPCR,ZNF837,HNRNPA3,RXRB,UBE2Q1,RSL1D1,MITF,NOL8,RB
1,HMGXB3,GNAI1,DHRS1,MZF1,ZFPM2,TP53BP1,MARK3,ZNF865,ISY
NA1,PUM2,SLFN11,STARD3,SUB1,FAM200B,AACS,STK38L,DDX6,ZN
F558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GARS,CYTH2,MRPS7,PL
K2,PAN2,ZNF605,CHFR,ZNF410,PTGR2,FMO2,GMDS,RPL24,MAST2,
VPS72,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,CSTF1,IKBKB,RFX7,NCOR
1,ATP11B,PPP1R10,MEF2A,PARN,FECH,ERAL1,PRKRIP1,STK19,PIA
S2,SSBP1,MAPK8,MYLK,DDX41,SRRM2,OSBPL3,PBX3,RNF213,N6A
MT1,ZNF565,ABCA2,RAB8A,TRIM28,DENND4C,DMTF1,MAP4K4,CSK,
CDK5RAP2,ITPA,PSMC6,SWAP70,IMPDH1,UBP1,SKIV2L2,CDK6,EBF
4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,KIFC2,UBA2,AAK1,
SP110,PHKG2,PAK1,RAB10,RHEB,HNRNPH3,TCF4,ACD,TRPM7,IKZF
5,HMGN2,SSBP2,CSF1R,TIMM50,DGKZ,ACTR2,NFYC,HSD17B4,PIWI
631
4
9
E
0
5
G
O:
00
43
23
4
protein complex
L4,RPUSD4,SRSF10,RCOR3,SMAD4,GRPEL2,ZNF114,MIER2,NAV1,D
TYMK,RPL4,MTRR,CENPT,ZNF44,CREBZF,RBMS1,EIF3M,ZNF687,CL
K3,NR2C2,FIP1L1,RAB5A,IRF9,BCS1L,ATP5A1,GLI3,NDUFV1,MAPK12
,NDUFS2,RASGRF2,AK5,THOC2,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4
,ZNF692,ETFA,GAPDH,ERCC1,MTRF1L,BICC1,NRBP2,STK36,SDHA,A
TP8B2,ARHGEF7,REXO2,MED6,MDFI,CIRBP,UBA6,ZNF554,IDH3B,PT
GR1,NUBP1,CIZ1,HINFP,NCBP2,MLX,PDGFRB,RAD51B,CDK11A,GLIS
3,BDP1,MYO7B,FARP1,DBF4,RAP1B,RUNX1,MKNK2,SMARCA4,LRPP
RC,RPLP0,DHX40,RAD54L2,ZNF518B,KIF13B,CRCP,CLK4,ZNF90,ZNF
638,DOCK8,ADRBK2,CHTF8,PHC3,DNAJC21,GSK3A,SIK3,SNRPE,TH
UMPD2,POLG,ZNF383,MRPL3,POLR2J3,NCOR2,FPGS,SETD2,TWF1,
PRPF4B,PTGIS,TROVE2,MYO1E,D2HGDH,ATXN3,NUCB1,PSTK,PHF2
1A,GPHN,PDCD4,ARL15,SOX13,ERI3,RGL2,CHD2,RABL3,LONP2,ZBE
D5,PSMA1,STAT6,CARS2,ACIN1,PSD3,CSNK1E,SON,ZNF138,ZNF705
A,NTRK1,TFAM,SHPRH,PHKG1,SMAD9,HBB,ZBTB16,BAZ2A,SIRT3,U
CK1,EIF3I,VARS,LARS,DHX37,SEPT2,LUC7L3,PDPK1,TSG101,THAP6
,USF1,FOXC1,ZC3H14,STK24,HEMK1,SSH1,RAPGEF6,GAK,MTO1,PA
BPC1,RBKS,PANK3,UBR5,FASTK,PHC2,SMARCAD1,WNK1,CC2D1A,Z
C3H15,DENND6B,PGRMC2,GATA2,PABPN1
CDK14,RNASEH2B,CRBN,PBX2,EIF2B4,GTF3C2,PSMB10,LAMB1,MY
O1D,SIRT2,UTRN,PPIL2,NLRP1,SEPT5,GAS8,CDK13,SPOP,CBX5,SU
PT5H,SUPT20H,HLADPB1,UBXN1,TBX2,MMS19,CNTF,GPAA1,NUP98,EED,FMR1,SMAD7,
cell HDAC6,ATP6V1D,DYNC1I1,RNH1,TTLL3,ARPC4-TTLL3,LEF1,HLAular C,SUPT4H1,PSMB9,ITGA9,BCL2L11,STARD9,COG4,HLA_co DQA1,RAD23A,AP3S2,APITD1,USP47,ADAM8,MAP7D1,CAPZB,DNAJ
mpo C10,PCGF6,KRIT1,SKIV2L,PTPN6,EEF1A1,ACTR3,CSNK2A1,UPF3A,P
nent RKACA,ANAPC4,DHX9,PIGS,PLK1,NUTF2,DNM1L,TXNL1,UPF1,HDGF
,NUP210,SEPT4,MIB2,SLC11A2,IL13RA1,CNP,PCGF1,VAMP7,DR1,CA
MK2D,HLADMB,BBS1,TNK2,FLG,DCAF11,RARS,COPS7B,VTI1A,GTF3C1,PMS1,T
IMM23,PAF1,SHARPIN,TCHP,RNF8,SEC31A,MDM2,ANAPC16,PPM1F,
1.21
381
056
1
7.
5
1
E
0
5
G
O:
00
48
85
8
cell projection morphogenesis
TBP,DIS3L,YY1,INO80,PFDN5,CREB1,SRP9,RPRD1A,AP4B1,ZEB1,EI
F4B,EMC3,ATG12,NUMA1,TPM4,MED28,PHF15,NIPBL,DCAF8,PKD2,S
TRN4,LMNA,MITF,ITGA3,RB1,PRMT5,GNAI1,PLEKHA2,STX16,TP53B
P1,BLOC1S5,RNF168,PAFAH1B1,SENP2,DNALI1,SUB1,ARPC2,SYNE
1,EPN2,USP33,BICD1,NRP1,CUL4A,VPS72,RUNX2,IQGAP1,FBXW7,IN
TS4,SMARCD3,IKBKB,RQCD1,PXN,KPNB1,NCOR1,PPP1R10,SMEK1,
WASH4P,ITGB5,TCTN1,CACNB1,CLTCL1,PBX3,HLAF,N6AMT1,ABCA2,DENND4C,CDK5RAP2,PSMC6,TBCD,EMC4,SKIV2L
2,DSN1,CDK6,WDR61,NUP37,APPL2,CLTB,FLOT1,PSMC4,KIFC2,GOP
C,RANBP9,WDR35,PHKG2,PARD6G,PAK1,RAB10,ZSWIM7,TCF4,CSF
1R,ATP6V0A1,ERC1,TIMM50,OS9,ACTR2,NFYC,TMED3,SS18,SMAD4,
FNTB,CHURC1FNTB,KLC1,NAV1,INO80E,EZR,CENPT,ING4,EIF3M,DNHD1,FIP1L1,DL
ST,FLNA,SUN2,MSL1,BCS1L,ACTR10,ATP5A1,GLI3,NDUFV1,DCAF6,
NDUFS2,THOC2,VEZT,ENG,SCFD1,SIRT7,TCF12,ARNT,NOX4,ERCC1
,PHF1,SLC25A6,SDHA,WWP1,ARHGEF7,PHF12,TBCE,NAT9,VAMP4,
MED6,NUP85,HAUS5,ITGA5,CLIP2,NCBP2,VPS51,DZIP1,NCAPD3,EL
P6,CC2D2A,DIABLO,ENO4,MYO7B,RAP1B,SMARCA4,LMNB1,NAA16,
LRPPRC,KIF13B,CRCP,DCAF17,KLHL7,PHC3,GSK3A,ITGA11,POLG,N
COR2,KANSL3,NARF,MYO1E,DYNC1I2,MAU2,PHF21A,PSMA1,CACN
B3,CLIC4,NSMCE4A,BNIP2,PHKG1,CACNA2D1,ATG3,SMAD9,HBB,TG
FBR3,ZBTB16,BAZ2A,SPCS3,EIF3I,RRP8,PHF19,SEPT2,UQCRH,PKD
1,USF1,FOXC1,KPNA1,PHC2,CLASP1,GATA2
FZD6,IGF1R,LAMB1,NPHP3,RAF1,COL9A1,BDNF,COL2A1,ARHGEF12
,CD72,TTLL3,ITGA9,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,CSN
biol K2A1,SLC11A2,CNP,BBS1,FGFR1,CAPRIN1,KIAA0586,SSH2,CREB1,R
1.53
ogic GMB,RPS6KA5,MAPK8IP3,PAFAH1B1,USP33,NRP1,PTEN,FYN,IFT172
806
al_p ,SRGAP2,MEF2A,TCTN1,CACNB1,MYCBP2,RAB8A,COL9A3,PTPRC,F
064
roce LOT1,RANBP9,WDR35,PAK1,NCK2,RAB10,SEMA6A,SEMA4D,ROBO3,
6
ss
EZR,FLNA,GLI3,EXT1,STK36,TBCE,ASAP1,UNC5B,PTPRD,ITGA5,DZI
P1,CC2D2A,FARP1,KIF13B,PTPN23,TLN1,TROVE2,ROBO2,CACNB3,
NTRK1,TMEM237,SEPT2,STK24,SSH1,C2CD3,CLASP1
7.
5
9
E
0
5
G
O:
00
06
51
1
ubiquitin-dependent protein catabolic
process
G
O:
00
12
50
5
endomembrane system
G
O:
adenyl ribonucleotide binding
biol
ogic
al_p
roce
ss
USP10,CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,USP4,HDAC6,DE
RL2,PSMB9,RAD23A,USP47,DNAJC10,ANAPC4,PLK1,HERC2,USP20,
WAC,RNF8,MDM2,RHBDD1,NUB1,USP24,USP3,RNF168,RNF217,USP
33,PAN2,USP7,CUL4A,CHFR,PTEN,FBXW7,HERPUD1,USP15,PSMC6,
RNF146,PSMC4,OS9,TGFB1I1,USP54,WWP1,UBA6,MAN1B1,USP40,A
TXN3,AMFR,PSMA1,CSNK1E,TSG101,UBR5
SLC16A3,CPE,CBX5,RAB34,HLADPB1,ST3GAL1,MARCH5,UBXN1,PLD1,VAPB,GPAA1,CUX1,NUP98,S
MPD4,GLG1,VRK2,DERL2,IL15RA,SYTL4,HLAC,BCL2L11,XYLT1,COG4,PAM,HSD17B12,HLADQA1,AP3S2,MPDU1,ADAM8,RAB35,CD9,RANBP1,MARCH6,RNF24,A
CTR3,PIGS,LMAN2,NUTF2,DNM1L,PTGES2,PIGG,NPC1,SHISA5,NUP
210,SLC11A2,CLN8,PIGN,VAMP7,CAMK2D,TNK2,VTI1A,SGK1,CYP2R
1,SEC31A,MDM2,RHBDD1,FKBP1A,MCFD2,SRP9,QSOX1,RHBDF1,SN
X21,REPS1,EMC3,RAB31,ALG6,ST3GAL4,GCNT2,PKD2,LMNA,GOLG
cell A8B,GOLGA8A,MAPK8IP3,STX16,PAFAH1B1,SENP2,EDEM2,CHMP1A
ular ,SYNE1,EPN2,GALNT2,ADAM15,FMO2,UST,HERPUD1,SNX17,KPNB1,
_co ATP11B,TMEM189,NECAB3,FIBP,CLSTN2,CLTCL1,MAN1A2,OSBPL3,
mpo HLAnent F,RAB8A,SLC35D2,DENND4C,TMEM66,STX18,EMC4,NUP37,CLTB,AA
K1,GOPC,ST6GALNAC5,PAK1,NCK2,LEPROT,RAB10,VPS45,ATP6V0
A1,ERC1,OS9,ELOVL1,FUT4,TMED3,SLC35A4,SLC39A7,MBOAT2,AU
P1,GOLPH3,CDC14B,SUN2,MGAT5,TMED2,RASGRF2,EPS15L1,EPN1
,B4GALT4,SCFD1,PCSK7,NOX4,EXT1,VTI1B,B3GAT3,PDIA5,VAMP4,N
UP85,MAN2A2,LPCAT1,EBPL,MAN1B1,CANX,LMNB1,LRPPRC,YIF1A,
RHBDF2,PAPPAAS1,PCYT1A,PIGO,PTGIS,WDFY3,CORO7,AMFR,CLIC4,BNIP2,LMF1,
SEC31B,ZDHHC8,PLOD2,SPCS3,LRP3,KPNA1,SLC9A8,CD63,ALG9,G
ORASP1
mol CDK14,DHX34,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,CDK13,A
ecul TP2B1,ERCC6L2,CMPK2,EEF2K,PGS1,VRK2,NARS,LANCL2,DGKA,P
1.72
555
884
2
7.
7
1
E
0
5
1.31
894
723
6
7.
8
7
E
0
5
1.34
351
7.
8
00
32
55
9
G
O:
00
03
72
3
G
O:
00
44
26
5
ar_f
unct
ion
RNA binding
cellular macromolecule catabolic process
NKP,STARD9,ABCC1,DDX23,MARK4,UHMK1,DDX39A,SKIV2L,MINK1,
ACTR3,CSNK2A1,NOD1,PRKACA,DHX9,PLK1,ASNS,UPF1,PDXK,CHD
6,CAMK2D,GALK2,TNK2,STK4,RARS,ALDH18A1,FGFR1,NADSYN1,P
MS1,ADCY4,PDE4D,SGK1,CHKB,NADK,PRKCH,IDH3G,INO80,NAGK,
DDX58,MAGI1,NEK3,NPR1,RPS6KA5,G3BP1,NTPCR,UBE2Q1,MARK3,
SLFN11,AACS,STK38L,DDX6,GARS,PLK2,MAST2,FYN,SRPK1,RUNX2
,IKBKB,ATP11B,STK19,MAPK8,MYLK,DDX41,RNF213,ABCA2,MAP4K4
,CSK,PSMC6,SWAP70,SKIV2L2,CDK6,FARSA,PSMC4,KIFC2,UBA2,AA
K1,PHKG2,PAK1,TRPM7,CSF1R,DGKZ,ACTR2,DTYMK,CLK3,BCS1L,A
TP5A1,MAPK12,AK5,NRBP2,STK36,ATP8B2,UBA6,NUBP1,PDGFRB,R
AD51B,CDK11A,MYO7B,RUNX1,MKNK2,SMARCA4,DHX40,RAD54L2,K
IF13B,CLK4,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4B,MYO1E,PSTK
,GPHN,CHD2,LONP2,CARS2,CSNK1E,NTRK1,SHPRH,PHKG1,UCK1,V
ARS,LARS,DHX37,PDPK1,STK24,GAK,RBKS,PANK3,FASTK,SMARCA
D1,WNK1
DHX34,EIF2B4,XRN1,TNRC6A,TRNAU1AP,SFSWAP,RBM6,FUBP1,EE
F2K,RBM17,FMR1,RBPMS,NOM1,SNRNP70,METTL3,UHMK1,NOL3,S
KIV2L,SUGP1,EEF1A1,UPF3A,RPP14,DHX9,UPF1,RC3H1,CNP,FYTTD
mol 1,FUBP3,RARS,PAIP1,CAPRIN1,CELF1,RNASET2,DAZAP1,DIS3L,YY1
ecul ,SRP9,DDX58,EIF4B,SERBP1,RPL9,G3BP1,HNRNPA3,RSL1D1,NOL8,
ar_f PUM2,SLFN11,DDX6,MRPS7,RPL24,CSTF1,PPP1R10,PARN,FECH,ER
unct AL1,PRKRIP1,DDX41,SRRM2,IMPDH1,PRPF8,FARSA,HNRNPL,HNRN
ion
PH3,TIMM50,PIWIL4,RPUSD4,SRSF10,RPL4,RBMS1,EIF3M,FIP1L1,TH
OC2,MTRF1L,BICC1,CIRBP,NCBP2,LRPPRC,RPLP0,ZNF638,SNRPE,T
HUMPD2,MRPL3,TROVE2,PSTK,PDCD4,PSMA1,SON,BAZ2A,EIF3I,LU
C7L3,ZC3H14,PABPC1,UBR5,PABPN1
USP10,RNASEH2B,CRBN,PSMB10,XRN1,SIRT2,SPOP,UBXN1,SMAD7
biol
,USP4,HDAC6,RNH1,DERL2,PNKP,PSMB9,RAD23A,USP47,DNAJC10,
ogic
UPF3A,PRKACA,ANAPC4,PLK1,UPF1,RC3H1,HERC2,CLN8,USP20,W
al_p
AC,PAIP1,RNASET2,RNF8,MDM2,RHBDD1,DIS3L,RPL27,RHBDF1,EIF
roce
4B,NUB1,RPL9,USP24,USP3,RNF168,RNF217,DDX6,USP33,PAN2,US
ss
P7,CUL4A,CHFR,RPL24,RPL37A,PTEN,FBXW7,HERPUD1,RQCD1,KP
089
4
9
E
0
5
1.47
289
525
3
8.
1
9
E
0
5
1.51
960
916
7
8.
4
1
E
0
G
O:
00
44
25
7
G
O:
00
30
16
3
G
O:
00
16
78
8
cellular protein catabolic process
protein catabolic process
hydrolase activity, acting on ester bonds
NB1,PARN,USP15,PSMC6,RNF146,PSMC4,OS9,TGFB1I1,RPL4,USP5
4,ERCC1,WWP1,UBA6,NCBP2,MAN1B1,USP40,RPLP0,ATXN3,AMFR,
LONP2,PSMA1,CSNK1E,TSG101,KPNA1,PABPC1,UBR5,SMARCAD1
USP10,CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,USP4,HDAC6,DE
biol RL2,PSMB9,RAD23A,USP47,DNAJC10,PRKACA,ANAPC4,PLK1,HERC
ogic 2,CLN8,USP20,WAC,RNF8,MDM2,RHBDD1,RHBDF1,NUB1,USP24,US
al_p P3,RNF168,RNF217,USP33,PAN2,USP7,CUL4A,CHFR,PTEN,FBXW7,H
roce ERPUD1,USP15,PSMC6,RNF146,PSMC4,OS9,TGFB1I1,USP54,WWP1,
ss
UBA6,MAN1B1,USP40,ATXN3,AMFR,LONP2,PSMA1,CSNK1E,TSG101
,UBR5
USP10,CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,USP4,HDAC6,HG
S,DERL2,PSMB9,RAD23A,USP47,ADAM8,DNAJC10,CSNK2A1,PRKAC
biol
A,ANAPC4,PLK1,HERC2,CLN8,USP20,WAC,RNF8,MDM2,RHBDD1,RH
ogic
BDF1,NUB1,USP24,USP3,RNF168,RNF217,TPP1,USP33,PAN2,USP7,
al_p
CUL4A,CHFR,PTEN,FYN,FBXW7,HERPUD1,USP15,PSMC6,RNF146,P
roce
SMC4,SGSM3,OS9,SMAD4,TGFB1I1,USP54,FLNA,WWP1,UBA6,LPCA
ss
T1,MAN1B1,USP40,GSK3A,ATXN3,AMFR,LONP2,PSMA1,CSNK1E,TS
G101,UBR5
USP10,ACADVL,XRN1,MYO1D,EPHX2,PLCD1,PTPN22,PLD1,VAPB,S
MPD4,USP4,RNH1,H6PD,PNKP,XBP1,USP47,PTPN6,CSNK2A1,IGBP1
,PRKACA,RPP14,PDE7B,ASNS,HDGF,PPP5C,ZC3H12A,CNP,PIGN,PL
CB4,USP20,FGFR1,ADCY4,PDE4D,RNASET2,SEC31A,FKBP1A,MTMR
11,PPM1F,DIS3L,SSH2,CREB1,ZCCHC9,PTPRK,G3BP1,NTPCR,NEDD
mol
8ecul
MDP1,MDP1,LMNA,USP24,USP3,GPCPD1,TPP1,SYTL2,PDE8A,ANXA
ar_f
5,USP33,BICD1,NR1H3,PAN2,USP7,PLD6,TENC1,MTMR14,PTEN,RNA
unct
SEK,PHPT1,PTP4A2,HERPUD1,PTPRF,PPP1R10,MEF2A,PARN,USP1
ion
5,PTPRS,PTPRC,MTMR9,SEMA4D,TIMM50,USP54,CDC14B,ERCC1,P
DIA5,REXO2,PTPRD,RGS2,PDGFRB,PTPN4,FARP1,USP40,YIF1A,PT
PN23,TLN1,GSK3A,NLGN2,POLG,PPAP2A,PDIA3,ATXN3,ERI3,NTRK1,
SPRED1,LMF1,DUSP6,PPT2,EGFL8,VARS,LARS,CES2,SSH1,EYA2,W
NK1,PLA2G16
5
1.68
032
832
9
8.
6
1
E
0
5
1.60
215
089
1
8.
9
8
E
0
5
1.41
511
453
6
9.
1
4
E
0
5
G
O:
00
19
94
1
G
O:
00
05
85
6
G
O:
00
33
55
modification-dependent protein catabolic
process
cytoskeleton
cellular response to stress
biol
ogic
al_p
roce
ss
USP10,CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,USP4,HDAC6,DE
RL2,PSMB9,RAD23A,USP47,DNAJC10,ANAPC4,PLK1,HERC2,USP20,
WAC,RNF8,MDM2,RHBDD1,NUB1,USP24,USP3,RNF168,RNF217,USP
33,PAN2,USP7,CUL4A,CHFR,PTEN,FBXW7,HERPUD1,USP15,PSMC6,
RNF146,PSMC4,OS9,TGFB1I1,USP54,WWP1,UBA6,MAN1B1,USP40,A
TXN3,AMFR,PSMA1,CSNK1E,TSG101,UBR5
MARVELD1,USP10,OBFC1,XRN1,MYO1D,SIRT2,UTRN,RAI14,TARS,S
EPT5,SLC16A3,GAS8,MMS19,SHMT2,CLNS1A,HDAC6,DYNC1I1,LANC
L2,SYTL4,TTLL3,ARPC4TTLL3,BCL2L11,STARD9,CEP135,MARK4,ADAM8,MAP7D1,CAPZB,RA
NBP1,SIPA1L1,KRIT1,MINK1,PDLIM5,RHOF,ACTR3,VASP,PRKACA,D
HX9,PLK1,SDCCAG8,NUTF2,TTC19,DNM1L,HERC2,SEPT4,SYMPK,C
NP,PLCB4,FLG,CCDC14,PDE4D,AFAP1,SHARPIN,DPF2,TCHP,KIAA05
86,ZFYVE26,DIS3L,TLN2,INO80,SSH2,TRAF3IP1,FLII,DDX58,NUMA1,T
cell
PM4,MED28,PKD2,LMNA,PPP2R3C,RB1,GNAI1,NEXN,PAFAH1B1,CAL
ular
COCO2,DNALI1,CHMP1A,ARPC2,SYNE1,STK38L,ZNF263,BICD1,PLK2
_co
,NRP1,DAAM1,SAP30BP,MAST2,FYN,IQGAP1,CEP112,PXN,SRGAP2,
mpo
NCOR1,TNS1,SMEK1,TCTN1,VILL,MYCBP2,CLTCL1,MYLK,ABCA2,RA
nent
B8A,CSK,CDK5RAP2,TBCD,DDHD2,FLOT1,KIFC2,GOPC,RANBP9,WD
R35,PAK1,EVC,ACTR2,SS18,SMAD4,FNTB,KLC1,NAV1,TGFB1I1,EZR,
MTRR,ZNF44,CLK3,DNHD1,FHOD1,FLNA,RAB5A,ACTR10,ADD3,AK5,
GAPDH,PHF1,TBCE,NUP85,CTTN,HAUS5,CLIP2,PTPN4,DZIP1,CC2D2
A,MYO7B,FARP1,LMNB1,LRPPRC,YIF1A,KIF13B,PTPN23,TLN1,PHC3,
TTLL11,TWF1,NARF,MYO1E,CORO7,DYNC1I2,NUCB1,GPHN,PSMA1,
TANC1,PSD3,CLIC4,BNIP2,SEPT2,THAP6,SSH1,C2CD3,CLASP1,CC2
D1A
biol USP10,ACADVL,EIF2B4,PSMB10,IGF1R,TNRC6A,SUPT5H,BCL6,TBX2
ogic ,MMS19,VAPB,HDAC6,VRK2,DERL2,PNKP,PSMB9,BCL2L11,XYLT1,X
al_p BP1,RAD23A,APITD1,USP47,ADAM8,DNAJC10,MINK1,IGBP1,NOD1,D
roce HX9,PLK1,ASNS,UPF1,HDGF,NPC1,HERC2,POLM,SLC11A2,ATG4B,B
ss
CLAF1,TBC1D14,WAC,PMS1,TAB2,SGK1,RNF8,SEC31A,MDM2,RHBD
1.70
042
934
4
1.
1
3
E
0
4
1.30
728
158
9
1.
2
5
E
0
4
1.37
342
370
1
1.
2
6
E
-
4
G
O:
00
04
67
2
D1,ZFYVE26,YY1,INO80,CREB1,PTPRK,ATG12,RPS6KA5,NIPBL,ALKB
H3,PKD2,CASP2,SLC12A6,LMNA,MAPK8IP3,USP3,TP53BP1,RNF168,
PAFAH1B1,IL18,TPP1,MUM1,USP7,CUL4A,FBXW7,HERPUD1,PXN,LT
BR,NCOR1,MEF2A,FECH,SETD8,MAPK8,MYLK,TRIM28,MAP4K4,PSM
C6,CDK6,PSMC4,PAK1,ZSWIM7,ACD,OS9,DGKZ,ALDH3B1,INO80E,IN
G4,CDC14B,MAPK12,ARNT,ERCC1,PHF1,NRBP2,PDIA5,MDFI,HINFP,
RAD51B,YIF1A,TLN1,FGF14,GSK3A,POLG,PTGIS,ATXN3,AMFR,PDC
D4,PSMA1,CSNK1E,NSMCE4A,SHPRH,SPRED1,TNFRSF10B,ATG3,H
BB,DUSP6,RRP8,STK24,UBR5,EYA2,SMARCAD1
CDK14,ACADVL,IGF1R,RAF1,CDK13,ZFP91,EEF2K,VAPB,VRK2,XBP1
,MARK4,UHMK1,ADAM8,MINK1,PTPN6,CSNK2A1,NOD1,PRKACA,PLK
1,ASNS,HDGF,CCNL1,FAM58A,CAMK2D,TNK2,STK4,FGFR1,ADCY4,T
AB2,SGK1,SEC31A,FKBP1A,PRKCH,PPM1F,CCNL2,NF1,NEK3,NPR1,
RPS6KA5,PKD2,LMNA,RB1,LTBP4,MAPK8IP3,MARK3,TPP1,STK38L,S
H3BP5,RGS3,PLK2,NRP1,MAST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,
HERPUD1,IKBKB,PXN,PRKRIP1,STK19,MAPK8,MYLK,TRIM28,MAP4K
4,CSK,PTPRC,CDK6,AAK1,PHKG2,PAK1,NCK2,TRPM7,CSF1R,CLK3,
MAPK12,AK5,ENG,NOX4,NRBP2,STK36,PDIA5,MDFI,RGS2,PDGFRB,
CDK11A,CARD14,MKNK2,YIF1A,CLK4,TLN1,ADRBK2,GSK3A,SIK3,TW
F1,PRPF4B,IGF2,PDCD4,CRIPAK,CSNK1E,CDK5RAP1,NTRK1,SPRED
1,TNFRSF10B,PHKG1,DUSP6,TGFBR3,PKD1,PDPK1,STK24,CDK5RA
P3,GAK,FASTK,WNK1
0
4
protein kinase activity
mol
ecul
ar_f
unct
ion
G
O:
00
43
63
2
modification-dependent macromolecule
catabolic process
USP10,CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,USP4,HDAC6,DE
biol
RL2,PSMB9,RAD23A,USP47,DNAJC10,ANAPC4,PLK1,HERC2,USP20,
ogic
WAC,RNF8,MDM2,RHBDD1,NUB1,USP24,USP3,RNF168,RNF217,USP
al_p
33,PAN2,USP7,CUL4A,CHFR,PTEN,FBXW7,HERPUD1,USP15,PSMC6,
roce
RNF146,PSMC4,OS9,TGFB1I1,USP54,WWP1,UBA6,MAN1B1,USP40,A
ss
TXN3,AMFR,PSMA1,CSNK1E,TSG101,UBR5
1.68
813
708
4
G
O:
00
endoplasmic reticulum lumen
cell
ular
_co
2.17
860
192
LEPRE1,COL9A1,COL2A1,H6PD,DNAJC10,COL16A1,COL14A1,RNAS
ET2,COL12A1,SERPINH1,COL18A1,FKBP10,TXNDC5,EDEM2,COL9A3
,OS9,P4HB,LRPAP1,PDIA5,COL8A1,CANX,SUMF2,PDIA3,COL13A1,K
1.39
557
747
3
1.
3
0
E
0
4
1.
3
6
E
0
4
1.
3
7
05
78
8
G
O:
00
35
63
9
mpo DELC2,CES2
nent
CDK14,DHX34,CKB,IGF1R,GK5,MYO1D,TARS,RAF1,NLRP1,SEPT5,C
DK13,ATP2B1,RAB34,ERCC6L2,CMPK2,GBP3,EEF2K,PGS1,VRK2,NA
RS,LANCL2,DGKA,PNKP,STARD9,ABCC1,DDX23,MARK4,UHMK1,RA
B35,DDX39A,SKIV2L,MINK1,RHOF,EEF1A1,ACTR3,CSNK2A1,NOD1,P
RKACA,DHX9,PLK1,ASNS,DNM1L,UPF1,PDXK,RHOBTB1,CHD6,SEPT
4,EFTUD2,RAB24,CAMK2D,GALK2,TNK2,STK4,MTG1,RARS,ALDH18A
1,FGFR1,RAB18,NADSYN1,PMS1,ADCY4,SGK1,CHKB,NADK,PRKCH,I
DH3G,INO80,NAGK,DDX58,MAGI1,NEK3,RTKN,NPR1,RPS6KA5,G3BP
1,RAB31,NTPCR,UBE2Q1,GNAI1,MARK3,SLFN11,AACS,STK38L,DDX
6,GARS,PLK2,MAST2,FYN,SRPK1,RUNX2,IKBKB,ATP11B,ERAL1,STK
19,MAPK8,MYLK,DDX41,RNF213,ABCA2,RAB8A,MAP4K4,CSK,PSMC6
,SWAP70,SKIV2L2,CDK6,FARSA,PSMC4,KIFC2,UBA2,AAK1,PHKG2,P
AK1,RAB10,RHEB,TRPM7,CSF1R,DGKZ,ACTR2,DTYMK,CLK3,RAB5A,
BCS1L,ATP5A1,MAPK12,AK5,NRBP2,STK36,ATP8B2,UBA6,NUBP1,PD
GFRB,RAD51B,CDK11A,MYO7B,RAP1B,RUNX1,MKNK2,SMARCA4,DH
X40,RAD54L2,KIF13B,CLK4,ADRBK2,GSK3A,SIK3,FPGS,TWF1,PRPF4
B,MYO1E,PSTK,GPHN,ARL15,CHD2,RABL3,LONP2,CARS2,CSNK1E,
NTRK1,SHPRH,PHKG1,UCK1,VARS,LARS,DHX37,SEPT2,PDPK1,STK
24,GAK,RBKS,PANK3,FASTK,SMARCAD1,WNK1
9
purine ribonucleoside triphosphate binding
mol
ecul
ar_f
unct
ion
G
O:
00
35
96
7
cellular response to topologically incorrect
protein
biol
ogic
ACADVL,VAPB,HDAC6,DERL2,XBP1,ASNS,HDGF,SEC31A,RHBDD1,L
al_p
MNA,TPP1,HERPUD1,PDIA5,YIF1A,TLN1,GSK3A,ATXN3,AMFR
roce
ss
2.60
760
628
9
G
O:
nuclear body
cell
ular
1.86
577
CDK13,CBX5,SART1,ZNF496,SNRNP70,METTL3,PRPF40A,CCNL1,EF
TUD2,FYTTD1,PRPF3,WAC,MDM2,CCNL2,RB1,SENP2,USP7,CHFR,P
1.29
629
163
6
E
0
4
1.
3
7
E
0
4
1.
4
3
E
0
4
1.
4
00
16
60
4
G
O:
00
90
30
4
_co TEN,PIAS2,SRRM2,PRPF8,ATPAF2,TIMM50,SRSF10,CLK3,HINFP,TG
mpo S1,FAM76B,MKNK2,ZNF638,NCOR2,ACIN1,SON,PNISR,ZBTB16,LUC7
nent L3,ZC3H14
nucleic acid metabolic process
FZD6,USP10,RNASEH2B,OBFC1,PBX2,KANK2,ACADVL,GTF3C2,RAI1
,PSMB10,XRN1,IGF1R,SIRT2,MYNN,NOC2L,TARS,ZNF131,RSC1A1,S
FSWAP,CDK13,RBM6,SIN3B,CBX5,SART1,SUPT5H,SUPT20H,PWP1,
BCL6,FUBP1,ZNF783,TBX2,MMS19,VAPB,CUX1,RBM17,CLNS1A,NUP
98,EED,SMAD7,MCF2L,PPFIBP2,HDAC6,EHMT1,RNH1,ZNF496,TYW1
B,NARS,LANCL2,PNKP,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,R
BPMS,ZSCAN31,XBP1,PAM,NOM1,SNRNP70,DDX23,RAD23A,METTL
3,APITD1,USP47,ADAM8,NOL3,POLR3E,GABPB1,PRPF40A,PCGF6,D
DX39A,SUGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,STAT2,R
PP14,DHX9,PLK1,ZNF446,ASNS,PTGES2,UPF1,ZNF621,HDGF,RC3H1
,PPP5C,CCNL1,HERC2,CHD6,ZC3H12A,POLM,SYMPK,EFTUD2,FAM5
biol 8A,CNP,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,Z
ogic NF710,PRPF3,WAC,ZNF142,FUBP3,RARS,ZNF540,FGFR1,HSF4,PAIP
al_p 1,GTF3C1,PMS1,CELF1,RNASET2,SF3A2,PAF1,TAB2,SGK1,DPF2,RN
roce F8,SEC31A,MDM2,ZFYVE26,PRKCH,PPM1F,ZNF595,TBP,DIS3L,YY1,I
ss
NO80,GMEB2,PFDN5,CREB1,FLII,RPRD1A,DDX58,RPL27,CCNL2,PTP
RK,ZEB1,EIF4B,IFITM3,ASCC2,RGMB,EBF1,RPL9,MED28,ZNF3,RPS6
KA5,G3BP1,NIPBL,ALKBH3,BRD9,ZNF837,PKD2,HNRNPA3,RXRB,LM
NA,MITF,NOL8,RB1,PRMT5,USP3,MZF1,ZFPM2,TP53BP1,RNF168,ZN
F865,SENP2,TPP1,SUB1,CHMP1A,PDE8A,NSA2,DDX6,ZNF558,MUM1
,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GARS,PAN2,USP7,PLD6,FLC
N,CUL4A,ZNF605,ZNF410,RPL24,RPL37A,SAP30BP,VPS72,PTEN,SR
PK1,RNASEK,RUNX2,CSTF1,FBXW7,INTS4,SMARCD3,HERPUD1,IKB
KB,RQCD1,KPNB1,RFX7,NCOR1,PPP1R10,MEF2A,PARN,SETD8,PIAS
2,SSBP1,MAPK8,MYCBP2,USP15,DDX41,SRRM2,PBX3,ZNF565,ABCA
2,AFF4,TRIM28,DMTF1,CDK5RAP2,PTPRC,PSMC6,SWAP70,UBP1,SK
IV2L2,WDR61,EBF4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,S
703
6
1.15
816
358
7
6
E
0
4
1.
6
1
E
0
4
G
O:
00
44
45
1
G
O:
00
16
nucleoplasm part
kinase activity
TAG2,SP110,PPA2,NCK2,HNRNPH3,ZSWIM7,TCF4,ACD,IKZF5,HMGN
2,WDR4,SEMA4D,SSBP2,ERC1,NFYC,PIWIL4,RPUSD4,SRSF10,SS18,
RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,RPL4,ZNF44,CREBZF,ING4,RB
MS1,ZNF687,CDC14B,CLK3,NR2C2,FHOD1,FIP1L1,DNTTIP2,FLNA,IR
F9,GLI3,MAPK12,CCDC59,DCAF6,THOC2,ENG,SIRT7,ZSCAN5A,TCF1
2,ARNT,NOX4,ZNF692,ERCC1,PHF1,STK36,WWP1,PHF12,PDIA5,REX
O2,MED6,MDFI,ZNF554,NAA10,CIZ1,HINFP,NCBP2,MLX,PDGFRB,TG
S1,NCAPD3,RAD51B,CDK11A,GLIS3,ELP6,BDP1,DBF4,RUNX1,SMAR
CA4,NAA16,LRPPRC,YIF1A,RPLP0,RAD54L2,CLASRP,ZNF518B,CRC
P,CLK4,ZNF90,ZNF638,PER3,TLN1,CHTF8,GSK3A,SNRPE,POLG,ZNF
383,POLR2J3,NCOR2,SETD2,PRPF4B,IGF2,PTGIS,FTSJ3,TROVE2,AT
XN3,PSTK,PHF21A,PDCD4,SOX13,ERI3,CHD2,PSMA1,STAT6,CARS2,
ACIN1,CSNK1E,SON,ZNF138,ZNF705A,CDK5RAP1,NSMCE4A,NTRK1,
TFAM,SHPRH,BRWD1,SMAD9,TGFBR3,ZFC3H1,ZBTB16,BAZ2A,RRP
8,VARS,LARS,PHF19,LMCD1,LUC7L3,PKD1,PDPK1,TSG101,USF1,FO
XC1,ARL6IP4,KPNA1,HEMK1,CDK5RAP3,MTO1,PABPC1,UBR5,FAST
K,EYA2,SMARCAD1,CC2D1A,GATA2,PABPN1
PBX2,GTF3C2,CDK13,CBX5,SART1,SUPT5H,SUPT20H,TBX2,MMS19,
EED,SMAD7,HDAC6,ZNF496,LEF1,SUPT4H1,SNRNP70,METTL3,APIT
D1,PRPF40A,CSNK2A1,HDGF,CCNL1,EFTUD2,DR1,FYTTD1,PRPF3,
cell
WAC,GTF3C1,PAF1,MDM2,TBP,YY1,CREB1,RPRD1A,CCNL2,ZEB1,M
ular
ED28,PHF15,RB1,SENP2,SUB1,USP7,CHFR,PTEN,RUNX2,INTS4,NC
_co
OR1,PIAS2,SRRM2,PBX3,WDR61,PRPF8,APPL2,ATPAF2,TCF4,TIMM5
mpo
0,NFYC,SRSF10,SMAD4,ING4,CLK3,FIP1L1,MSL1,GLI3,TCF12,ARNT,
nent
PHF1,PHF12,MED6,HINFP,TGS1,FAM76B,MKNK2,NAA16,ZNF638,NC
OR2,KANSL3,PHF21A,ACIN1,SON,PNISR,SMAD9,ZBTB16,PHF19,LUC
7L3,USF1,FOXC1,ZC3H14
mol CDK14,ACADVL,CKB,IGF1R,GK5,RAF1,CDK13,CMPK2,ZFP91,EEF2K,
ecul VAPB,VRK2,DGKA,PNKP,XBP1,MARK4,UHMK1,ADAM8,MINK1,PTPN6
ar_f ,CSNK2A1,NOD1,PRKACA,PLK1,ASNS,HDGF,PDXK,CCNL1,FAM58A,
unct CAMK2D,GALK2,TNK2,STK4,ALDH18A1,FGFR1,ADCY4,TAB2,SGK1,C
1.46
248
556
3
1.
8
6
E
0
4
1.34
662
628
1
1.
8
9
E
30
1
G
O:
00
31
32
4
G
O:
00
43
00
ion
negative regulation of cellular metabolic
process
Golgi to plasma membrane protein transport
HKB,NADK,SEC31A,FKBP1A,PRKCH,PPM1F,NAGK,CCNL2,NF1,NEK3
,NPR1,RPS6KA5,PKD2,LMNA,RB1,HMGXB3,LTBP4,MAPK8IP3,MARK3
,TPP1,STK38L,SH3BP5,RGS3,PLK2,NRP1,MAST2,PTEN,FYN,SRPK1,I
QGAP1,FBXW7,HERPUD1,IKBKB,PXN,PRKRIP1,STK19,MAPK8,MYLK,
TRIM28,MAP4K4,CSK,PTPRC,CDK6,AAK1,PHKG2,PAK1,NCK2,TRPM7
,CSF1R,DGKZ,DTYMK,CLK3,MAPK12,AK5,ENG,NOX4,NRBP2,STK36,
PDIA5,MDFI,RGS2,PDGFRB,CDK11A,CARD14,MKNK2,YIF1A,CLK4,TL
N1,ADRBK2,GSK3A,SIK3,TWF1,PRPF4B,IGF2,PSTK,PDCD4,CRIPAK,
CSNK1E,CDK5RAP1,NTRK1,SPRED1,TNFRSF10B,PHKG1,DUSP6,TG
FBR3,UCK1,PKD1,PDPK1,STK24,CDK5RAP3,GAK,RBKS,PANK3,FAST
K,WNK1
KANK2,ACADVL,EIF2B4,PSMB10,IGF1R,TNRC6A,SIRT2,NOC2L,SFS
WAP,SIN3B,CBX5,SUPT5H,UBXN1,BCL6,TBX2,CUX1,EED,FMR1,SMA
D7,USP4,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,PSMB9,US
P47,DNAJC10,PCGF6,PTPN6,IGBP1,ANAPC4,PLK1,HDGF,NPC1,ZC3
H12A,CLN8,TBX18,DR1,BCLAF1,GIGYF2,TBC1D14,WAC,ZNF540,FGF
R1,HSF4,CAPRIN1,CELF1,PAF1,RNF8,MDM2,PPM1F,YY1,PFDN5,CR
biol
EB1,SRP9,PTPRK,NF1,ZEB1,IFITM3,RPS6KA5,NIPBL,RB1,PRMT5,ZF
ogic
PM2,RNF168,CHMP1A,SH3BP5,ZNF263,RGS3,NR1H3,GRB10,FLCN,V
al_p
PS72,PTEN,RUNX2,IQGAP1,FBXW7,NCOR1,MEF2A,PRKRIP1,SETD8,
roce
TRIM28,PTPRC,PSMC6,UBP1,ZNF148,PSMC4,STAG2,TCF4,ACD,SEM
ss
A4D,SRSF10,SMAD4,C1QTNF3,CREBZF,ING4,CD276,GLI3,ENG,SIRT
7,GAPDH,ERCC1,PHF1,NRBP2,WWP1,PHF12,MDFI,CIRBP,RGS2,HIN
FP,LPCAT1,MLX,GLIS3,SMARCA4,PER3,GSK3A,NCOR2,PTGIS,PHF2
1A,PDCD4,CRIPAK,PSMA1,STAT6,CDK5RAP1,SPRED1,DUSP6,ZBTB
16,BAZ2A,RRP8,LMCD1,PDPK1,TSG101,PABPC1,UBR5,WNK1,CC2D1
A,GATA2
biol
ogic
al_p VAMP7,BBS1,RAB31,GCC2,CSK,GOPC,RAB10,VAMP4
roce
ss
0
4
1.33
382
9
2.
1
1
E
0
4
4.49
087
749
8
2.
2
6
E
-
1
G
O:
00
06
46
8
G
O:
00
04
72
5
G
O:
00
19
22
2
0
4
protein phosphorylation
CDK14,ACADVL,IGF1R,RAF1,CDK13,ST3GAL1,ZFP91,CNTF,EEF2K,V
APB,SMAD7,VRK2,RBPMS,XBP1,MARK4,UHMK1,ADAM8,DNAJC10,MI
NK1,PTPN6,CSNK2A1,NOD1,PRKACA,PLK1,ASNS,HDGF,CCNL1,FAM
58A,CAMK2D,TNK2,STK4,FGFR1,ADCY4,TAB2,SGK1,SEC31A,FKBP1
A,PRKCH,PPM1F,CREB1,NPTN,CCNL2,NF1,NEK3,NPR1,RPS6KA5,PK
biol D2,LMNA,RB1,LTBP4,MAPK8IP3,MARK3,SENP2,TPP1,STK38L,SH3BP
ogic 5,RGS3,PLK2,FLCN,NRP1,MAST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,
al_p HERPUD1,IKBKB,PXN,FECH,PRKRIP1,STK19,MAPK8,MYLK,USP15,T
roce RIM28,MAP4K4,CSK,PTPRC,CDK6,AAK1,PHKG2,PAK1,NCK2,TRPM7,
ss
SEMA4D,CSF1R,ERC1,C3,SMAD4,CLK3,MAPK12,AK5,ENG,NOX4,NR
BP2,STK36,PDIA5,MDFI,ITGA5,RGS2,PDGFRB,CDK11A,CARD14,TNF
RSF14,MKNK2,YIF1A,CLK4,TLN1,ADRBK2,GSK3A,SIK3,TWF1,PRPF4
B,IGF2,PDCD4,CRIPAK,CSNK1E,CDK5RAP1,NTRK1,SPRED1,TNFRS
F10B,PHKG1,SMAD9,DUSP6,TGFBR3,PKD1,PDPK1,STK24,CDK5RAP
3,GAK,FASTK,WNK1
protein tyrosine phosphatase activity
mol
ecul
ar_f
unct
ion
regulation of metabolic process
FZD6,USP10,OBFC1,RAB3GAP2,PBX2,KANK2,ACADVL,EIF2B4,RAI1,
PSMB10,IGF1R,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,RALGAPA2,MYN
biol
N,TRNAU1AP,NOC2L,RAF1,NLRP1,ZNF131,RSC1A1,SFSWAP,CDK13,
ogic
BDNF,SIN3B,CBX5,COL2A1,SUPT5H,SUPT20H,UBXN1,BCL6,FUBP1,Z
al_p
NF783,TBX2,MMS19,ZFP91,CNTF,EEF2K,VAPB,CUX1,EED,FMR1,SM
roce
AD7,MCF2L,USP4,HDAC6,GLG1,ARHGEF12,EHMT1,RNH1,ZNF496,H
ss
GS,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,ARHGEF25,R
GL4,BCL2L13,BCL2L11,RBPMS,STARD13,ZSCAN31,XBP1,PAM,SNRN
PTPN22,PTPN6,SSH2,PTPRK,MDP1,MTMR14,PTEN,PTP4A2,PTPRF,P
TPRS,PTPRC,TIMM50,CDC14B,PTPRD,PTPN4,PTPN23,DUSP6,SSH1,
EYA2
1.34
121
266
6
2.
3
0
E
0
4
2.44
408
089
7
2.
3
0
E
0
4
1.13
393
055
2
2.
3
5
E
0
4
P70,RAD23A,APITD1,UHMK1,USP47,ADAM8,GABPB1,DNAJC10,PCG
F6,RANBP1,SIPA1L1,KRIT1,MINK1,PTPN6,EEF1A1,LHX4,CSNK2A1,IG
BP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC4,DHX9,PLK1,ZNF446,ASN
S,TBC1D2B,PTGES2,UPF1,ZNF621,HDGF,RC3H1,NPC1,CCNL1,HERC
2,CHD6,ZC3H12A,TBC1D10B,SEPT4,SLC11A2,SYMPK,FAM58A,ATG4
B,CLN8,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,Z
NF710,GIGYF2,TBC1D14,TNK2,GIT2,WAC,STK4,ZNF142,FUBP3,ZNF5
40,FGFR1,HPS4,HSF4,C2,CFB,PAIP1,CAPRIN1,MMP16,ADCY4,CELF1
,PAF1,TAB2,SGK1,PLEKHG4,DPF2,CPT1B,RNF8,SEC31A,MDM2,RHB
DD1,FKBP1A,PRKCH,PPM1F,ZNF595,TBP,YY1,FAM13A,INO80,GMEB
2,PFDN5,CREB1,NPTN,SRP9,RALGPS2,FLII,PLEKHG5,RPRD1A,DDX5
8,ZCCHC9,CCNL2,PTPRK,SNX13,RHBDF1,SERPINH1,NF1,ZEB1,EIF4
B,CRIP1,SERBP1,NUB1,IFITM3,ASCC2,RGMB,RTKN,EBF1,MED28,NP
R1,ZNF3,RPS6KA5,NIPBL,ALKBH3,BRD9,ZNF837,PKD2,RXRB,LMNA,
MITF,RB1,PRMT5,LTBP4,MAPK8IP3,USP3,MZF1,ZFPM2,TP53BP1,RN
F168,PAFAH1B1,ZNF865,SENP2,IL18,PUM2,MTCH1,TPP1,SYTL2,SUB
1,CHMP1A,PDE8A,ACAP2,ZNF558,ANXA5,SH3BP5,ZNF263,ZNF180,BI
CD1,ZNF276,RGS3,NR1H3,CYTH2,GRB10,USP7,PLD6,FLCN,NRP1,C
UL4A,ZNF605,ZNF410,ARHGAP9,SAP30BP,MAST2,VPS72,PTEN,FYN,
SRPK1,RUNX2,IQGAP1,FBXW7,PHPT1,SMARCD3,HERPUD1,IKBKB,R
QCD1,PXN,SRGAP2,RFX7,NCOR1,PPP1R10,MEF2A,FECH,PRKRIP1,
SETD8,SMEK1,NECAB3,PIAS2,SSBP1,MAPK8,MYCBP2,UPK3B,USP1
5,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DENND4C,DMTF1,MAP4
K4,CSK,CDK5RAP2,PTPRC,OAZ1,PSMC6,TBCD,UBP1,CDK6,WDR61,
EBF4,ZNF148,ZNF76,PSMC4,ARHGAP29,SGSM3,STAG2,UBA2,AAK1,
SP110,GOPC,PHKG2,PAK1,NCK2,LEPR,MTMR9,CTSH,ZSWIM7,TCF4,
ACD,IKZF5,HMGN2,SEMA4D,SSBP2,CSF1R,ERC1,DGKZ,C3,NFYC,PI
WIL4,SRSF10,SS18,RCOR3,SMAD4,GRPEL2,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,C1QTNF3,TGFB1I1,DDAH1,INO80E,
ZNF44,CREBZF,ING4,CD276,ZNF687,CDC14B,CLK3,NR2C2,FHOD1,D
NTTIP2,FLNA,IRF9,GLI3,TMED2,MAPK12,CCDC59,DCAF6,RASGRF2,
AK5,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZNF692,GAPDH,ERCC
1,PHF1,NRBP2,STK36,WWP1,ARHGEF7,PHF12,PDIA5,ASAP1,MED6,
MDFI,CIRBP,ZNF554,CIZ1,ITGA5,RGS2,HINFP,NCBP2,LPCAT1,MLX,P
DGFRB,TGS1,CDK11A,GLIS3,ELP6,CARD14,BDP1,DIABLO,FARP1,TN
FRSF14,DBF4,RUNX1,MKNK2,SMARCA4,NAA16,LRPPRC,YIF1A,RAD
54L2,ZNF518B,CLK4,ZNF90,ZNF638,PER3,TLN1,DOCK8,GSK3A,ZNF3
83,NCOR2,SETD2,TWF1,PPAP2A,IGF2,PTGIS,ATXN3,PSTK,PHF21A,
PDCD4,SOX13,RGL2,CHD2,CRIPAK,LONP2,PSMA1,STAT6,PSD3,CSN
K1E,SON,ZNF138,ZNF705A,CDK5RAP1,BNIP2,NTRK1,TFAM,SPRED1,
TNFRSF10B,BRWD1,SMAD9,HBB,LMF1,DUSP6,TGFBR3,ZBTB16,BAZ
2A,CPAMD8,RRP8,VARS,LARS,PHF19,LMCD1,SEPT2,PKD1,PDPK1,T
SG101,USF1,FOXC1,KPNA1,DDAH2,HEMK1,SSH1,CDK5RAP3,RAPG
EF6,C2CD3,PABPC1,UBR5,FASTK,EYA2,SMARCAD1,WNK1,CC2D1A,
DENND6B,GATA2
G
O:
00
35
33
5
G
O:
00
16
77
2
peptidyl-tyrosine dephosphorylation
transferase activity, transferring
phosphorus-containing groups
biol
ogic PTPN22,PTPN6,SSH2,PTPRK,MDP1,MTMR14,PTEN,PTP4A2,PTPRF,P
al_p TPRS,PTPRC,TIMM50,CDC14B,PTPRD,PTPN4,PTPN23,DUSP6,SSH1,
roce EYA2
ss
mol
ecul
ar_f
unct
ion
CDK14,ACADVL,CKB,IGF1R,GK5,RAF1,CDK13,CMPK2,ZFP91,EEF2K,
VAPB,PGS1,VRK2,DGKA,PNKP,XBP1,MARK4,UHMK1,ADAM8,POLR3
E,MINK1,PTPN6,CSNK2A1,NOD1,PRKACA,PLK1,ASNS,HDGF,PIGG,P
DXK,CCNL1,POLM,FAM58A,CAMK2D,GALK2,TNK2,STK4,ALDH18A1,F
GFR1,ADCY4,TAB2,SGK1,CHKB,NADK,SEC31A,FKBP1A,PRKCH,PPM
1F,NAGK,CCNL2,NF1,NEK3,NPR1,RPS6KA5,PKD2,GALT,LMNA,RB1,H
MGXB3,LTBP4,MAPK8IP3,MARK3,TPP1,STK38L,SH3BP5,RGS3,PLK2,
NRP1,MAST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,HERPUD1,IKBKB,PX
N,PRKRIP1,STK19,MAPK8,MYLK,TRIM28,MAP4K4,CSK,PTPRC,CDK6,
AAK1,PHKG2,PAK1,NCK2,ACD,TRPM7,CSF1R,DGKZ,DTYMK,CLK3,M
APK12,AK5,ENG,NOX4,NRBP2,STK36,PDIA5,MDFI,RGS2,PDGFRB,C
DK11A,CARD14,MKNK2,YIF1A,CRCP,CLK4,TLN1,ADRBK2,GSK3A,SIK
2.43
790
492
7
2.
3
8
E
0
4
1.31
661
014
8
2.
9
6
E
0
4
3,POLG,POLR2J3,TWF1,PCYT1A,PRPF4B,IGF2,PSTK,PDCD4,CRIPAK
,CSNK1E,CDK5RAP1,NTRK1,SPRED1,TNFRSF10B,PHKG1,DUSP6,TG
FBR3,UCK1,PKD1,PDPK1,STK24,CDK5RAP3,GAK,RBKS,PANK3,FAST
K,WNK1
G
O:
00
51
65
1
G
O:
00
60
25
5
maintenance of location in cell
biol
ogic
GPAA1,TLN2,PKD2,RB1,SYNE1,BICD1,GCC2,GOPC,OS9,EZR,FLNA,S
al_p
UN2,GAA,MDFI,CIZ1,TLN1,PDIA3,PKD1,CLASP1
roce
ss
regulation of macromolecule metabolic
process
FZD6,OBFC1,PBX2,KANK2,ACADVL,EIF2B4,RAI1,PSMB10,IGF1R,TNR
C6A,SIRT2,EPHX2,MYNN,TRNAU1AP,NOC2L,RAF1,ZNF131,RSC1A1,
SFSWAP,CDK13,SIN3B,CBX5,COL2A1,SUPT5H,SUPT20H,UBXN1,BC
L6,FUBP1,ZNF783,TBX2,MMS19,ZFP91,CNTF,EEF2K,VAPB,CUX1,EE
D,FMR1,SMAD7,MCF2L,USP4,HDAC6,GLG1,EHMT1,ZNF496,HGS,LA
NCL2,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,RBPMS,ZSCAN31,X
BP1,PAM,SNRNP70,RAD23A,APITD1,UHMK1,USP47,ADAM8,GABPB1,
DNAJC10,PCGF6,PTPN6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD
biol 1,PRKACA,STAT2,ANAPC4,DHX9,PLK1,ZNF446,ASNS,PTGES2,UPF1,
ogic ZNF621,HDGF,RC3H1,CCNL1,CHD6,ZC3H12A,SEPT4,SYMPK,FAM58
al_p A,CLN8,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,Z
roce NF710,GIGYF2,TNK2,WAC,STK4,ZNF142,FUBP3,ZNF540,FGFR1,HPS
ss
4,HSF4,C2,CFB,PAIP1,CAPRIN1,ADCY4,CELF1,PAF1,TAB2,SGK1,DP
F2,RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,PRKCH,PPM1F,ZNF595,T
BP,YY1,INO80,GMEB2,PFDN5,CREB1,NPTN,SRP9,FLII,RPRD1A,DDX
58,CCNL2,PTPRK,RHBDF1,SERPINH1,NF1,ZEB1,EIF4B,CRIP1,SERB
P1,NUB1,IFITM3,ASCC2,RGMB,EBF1,MED28,ZNF3,RPS6KA5,NIPBL,A
LKBH3,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,LTBP4,MA
PK8IP3,USP3,MZF1,ZFPM2,TP53BP1,RNF168,ZNF865,SENP2,IL18,PU
M2,TPP1,SUB1,CHMP1A,PDE8A,ZNF558,SH3BP5,ZNF263,ZNF180,BI
CD1,ZNF276,RGS3,NR1H3,GRB10,USP7,PLD6,FLCN,NRP1,CUL4A,ZN
2.39
233
661
1
3.
0
6
E
0
4
1.15
344
850
1
3.
1
0
E
0
4
G
O:
00
00
90
4
cell morphogenesis involved in
differentiation
F605,ZNF410,SAP30BP,MAST2,VPS72,PTEN,FYN,SRPK1,RUNX2,IQG
AP1,FBXW7,SMARCD3,HERPUD1,IKBKB,RQCD1,PXN,RFX7,NCOR1,
MEF2A,FECH,PRKRIP1,SETD8,NECAB3,PIAS2,MAPK8,MYCBP2,UPK
3B,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CSK,CD
K5RAP2,PTPRC,PSMC6,UBP1,CDK6,WDR61,EBF4,ZNF148,ZNF76,PS
MC4,SGSM3,STAG2,AAK1,SP110,PHKG2,PAK1,NCK2,CTSH,ZSWIM7,
TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,CSF1R,ERC1,C3,NFYC,PI
WIL4,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,INO80E,ZNF44,CREBZF,ING
4,CD276,ZNF687,CDC14B,CLK3,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,
GLI3,TMED2,MAPK12,CCDC59,DCAF6,AK5,ENG,SIRT7,ZSCAN5A,TC
F12,ARNT,NOX4,ZNF692,GAPDH,ERCC1,PHF1,STK36,WWP1,PHF12,
PDIA5,MED6,MDFI,CIRBP,ZNF554,CIZ1,ITGA5,RGS2,HINFP,NCBP2,L
PCAT1,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,CARD14,BDP1,TNF
RSF14,RUNX1,MKNK2,SMARCA4,NAA16,LRPPRC,YIF1A,RAD54L2,ZN
F518B,CLK4,ZNF90,ZNF638,PER3,TLN1,GSK3A,ZNF383,NCOR2,SET
D2,TWF1,IGF2,PTGIS,ATXN3,PSTK,PHF21A,PDCD4,SOX13,CHD2,CRI
PAK,PSMA1,STAT6,CSNK1E,SON,ZNF138,ZNF705A,CDK5RAP1,NTR
K1,TFAM,SPRED1,TNFRSF10B,BRWD1,SMAD9,DUSP6,TGFBR3,ZBT
B16,BAZ2A,RRP8,VARS,LARS,PHF19,LMCD1,PKD1,PDPK1,TSG101,U
SF1,FOXC1,KPNA1,HEMK1,SSH1,CDK5RAP3,C2CD3,PABPC1,UBR5,
FASTK,EYA2,SMARCAD1,WNK1,CC2D1A,GATA2
FZD6,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,SMAD7,ARHGEF12
,CD72,LEF1,PAX8,ITGA9,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,
biol CSNK2A1,SLC11A2,CNP,FGFR1,CAPRIN1,SSH2,CREB1,RGMB,COL1
ogic 8A1,RPS6KA5,RB1,MAPK8IP3,PAFAH1B1,ARPC2,ADAM15,USP33,HE
al_p XA,NRP1,PTEN,FYN,SRGAP2,MEF2A,TCTN1,CACNB1,MYCBP2,RAB8
roce A,TRIM28,COL9A3,PTPRC,FLOT1,RANBP9,PAK1,NCK2,RAB10,SEMA
ss
6A,SEMA4D,ROBO3,SMAD4,TGFB1I1,EZR,FLNA,GLI3,EXT1,TBCE,UN
C5B,PTPRD,ITGA5,FARP1,KIF13B,TLN1,ROBO2,CACNB3,CLIC4,NTR
K1,TGFBR3,FOXC1,STK24,SSH1,CLASP1
1.47
386
442
4
3.
2
8
E
0
4
G
O:
00
30
93
4
G
O:
00
05
79
4
G
O:
00
35
86
1
anchoring collagen
cell
ular
_co COL9A1,COL16A1,COL14A1,COL12A1,COL9A3
mpo
nent
Golgi apparatus
PLEKHA3,XRN1,EPHX2,PPIL2,GAS8,RSC1A1,CPE,SART1,CCDC91,R
AB34,HLADPB1,ST3GAL1,PLD1,VAPB,CUX1,SMPD4,GLG1,IL15RA,HLAC,XYLT1,COG4,ABCC1,HLADQA1,AP3S2,MINK1,RNF24,ACTR3,VPS52,LMAN2,DNM1L,PTGES2,P
PP5C,NPC1,VAMP7,TBC1D14,VTI1A,MMP16,SNAP23,MCFD2,QSOX1,
cell AP4B1,RHBDF1,RAB31,ST3GAL4,GCNT2,GALT,UBAC1,GOLGA8B,GO
ular LGA8A,MAPK8IP3,GNAI1,STX16,CALCOCO2,SYTL2,ARPC2,SYNE1,G
_co ALNT2,BICD1,GCC2,IGFBP6,UST,FBXW7,SNX17,DYM,NECAB3,CLST
mpo N2,CLTCL1,MAN1A2,HLAnent F,RAB8A,SLC35D2,CSK,CDK5RAP2,STX18,NSFL1C,DDHD2,ZNF148,
CLTB,GOPC,ST6GALNAC5,PAK1,LEPROT,RAB10,VPS45,ATP6V0A1,E
RC1,FUT4,TMED3,SLC35A4,GOLPH3,MGAT5,TMED2,B4GALT4,SCFD
1,PCSK7,EXT1,VTI1B,B3GAT3,VAMP4,MAN2A2,LPCAT1,VPS51,YIF1A
,ZNF90,CORO7,CORO7PAM16,NUCB1,LMF1,SLC9A8,ACAN,SCAMP1,FMOD,GAK,CLASP1,G
ORASP1
site of double-strand break
cell
ular
_co RNF8,RNF168,PHF1,SMARCAD1
mpo
nent
6.99
666
388
7
3.
4
4
E
0
4
1.36
375
652
3.
4
5
E
0
4
9.32
888
518
2
3.
4
6
E
0
4
G
O:
00
60
27
1
cilium morphogenesis
G
O:
00
06
99
6
organelle organization
G
O:
RNA splicing
biol
ogic NPHP3,TTLL3,ACTR3,BBS1,KIAA0586,IFT172,TCTN1,RAB8A,WDR35,
al_p FLNA,STK36,ASAP1,DZIP1,CC2D2A,PTPN23,TROVE2,TMEM237,SEP
roce T2,C2CD3
ss
OBFC1,SIRT2,NOC2L,RAF1,CDK13,TAZ,RAB34,SUPT5H,MARCH5,BC
L6,NUP98,EED,HDAC6,EHMT1,ATP6V1D,TTLL3,ARPC4TTLL3,LEF1,SUPT4H1,BCL2L11,STARD9,COG4,NISCH,PAM,CEP135,
APITD1,MARK4,CAPZB,PRPF40A,RANBP1,SIPA1L1,MINK1,RHOF,AC
TR3,VASP,ANAPC4,PLK1,TTC19,DNM1L,PPP5C,CHD6,SEPT4,ATG4B,
CNP,CLN8,PCGF1,VAMP7,DR1,JHDM1D,TBC1D14,WAC,HPS4,HSF4,
TIMM23,PAF1,SHARPIN,RNF8,SEC31A,ANAPC16,PPM1F,YY1,TLN2,I
NO80,SSH2,LIMCH1,NF1,NEK3,ATG12,NUMA1,PHF15,RPS6KA5,NIPB
L,RAB31,BRD9,CAPN10,PKD2,LMNA,RB1,PRMT5,GNAI1,USP3,BLOC1
biol S5,NEXN,RNF168,PAFAH1B1,TPP1,CHMP1A,ARPC2,SYNE1,MUM1,BI
ogic CD1,NTMT1,GCC2,CYTH2,PLK2,HEXA,PLD6,FLCN,CHFR,DAAM1,VPS
al_p 72,PTEN,SRPK1,FBXW7,PHPT1,SMARCD3,PXN,SRGAP2,NCOR1,ME
roce F2A,DYM,ERAL1,SETD8,WASH4P,SSBP1,VILL,MAPK8,MYCBP2,CLTC
ss
L1,RAB8A,CDK5RAP2,ITPA,TBCD,DSN1,WDR61,NUP37,COX14,STAG
2,GOPC,RANBP9,PAK1,NCK2,RAB10,SEMA6A,ACD,TRPM7,HMGN2,C
SF1R,ATP6V0A1,TIMM50,ACTR2,SS18,GRPEL2,NAV1,EZR,CENPT,G
OLPH3,ING4,CDCA3,HPS3,FHOD1,FLNA,SUN2,MSL1,BCS1L,TMED2,
SIRT7,NOX4,GAPDH,ERCC1,PHF1,GAA,SLC25A6,TBCE,NUP85,HAUS
5,PDGFRB,NCAPD3,CDK11A,SMARCA4,SDAD1,TLN1,POLG,SETD2,T
WF1,KANSL3,IGF2,ATXN3,CORO7,MAU2,PHF21A,CRIPAK,LONP2,ACI
N1,SON,CLIC4,BNIP2,TFAM,SHPRH,ATG3,BRWD1,BAZ2A,RRP8,PHF
19,LETM1,SEPT2,SENP6,PDPK1,SSH1,MTO1,UBR5,EYA2,SMARCAD
1,CLASP1,GATA2,GORASP1
biol SFSWAP,CDK13,SART1,RBM17,CLNS1A,SNRNP70,DDX23,NOL3,PRP
ogic F40A,DDX39A,SUGP1,DHX9,EFTUD2,PRPF3,CELF1,SF3A2,HNRNPA3
2.37
018
534
6
3.
4
7
E
0
4
1.24
288
504
3.
6
0
E
0
4
1.72
515
3.
6
00
08
38
0
G
O:
00
30
02
0
G
O:
00
32
44
6
G
O:
00
71
82
6
G
O:
00
10
60
al_p ,PRMT5,SRPK1,CSTF1,DDX41,SRRM2,SKIV2L2,PRPF8,HNRNPL,HNR
roce NPH3,SRSF10,CLK3,THOC2,NCBP2,TGS1,CLASRP,CLK4,ZNF638,SN
ss
RPE,PRPF4B,SON,LUC7L3,ARL6IP4,PABPC1,FASTK,PABPN1
416
1
extracellular matrix structural constituent
conferring tensile strength
mol
ecul
ar_f
unct
ion
protein modification by small protein
conjugation
CRBN,PSMB10,PPIL2,SPOP,MARCH5,UBXN1,FBXO32,ZFP91,SMAD7,
USP4,HDAC6,PSMB9,APITD1,RNF220,MARCH6,ANAPC4,PLK1,RC3H
biol
1,HERC2,SEPT4,MIB2,PCGF1,DCAF11,WAC,PAF1,SHARPIN,RNF8,M
ogic
DM2,FKBP1A,ANAPC16,NUB1,SPSB3,UNKL,DCAF8,UBE2Q1,UBAC1,
al_p
RNF168,RNF217,CUL4A,CHFR,PTEN,FBXW7,HERPUD1,PIAS2,MYCB
roce
P2,RNF213,TRIM28,PSMC6,RNF146,PSMC4,UBA2,OS9,ASB8,CDCA3,
ss
CDC14B,DCAF6,ARNT,WWP1,UBA6,TRIM41,DCAF17,KLHL7,FBXW2,
AMFR,PSMA1,SHPRH,ATG3,ZBTB16,SENP6,UBR5
ribonucleoprotein complex subunit
organization
biol
ogic SFSWAP,SART1,CLNS1A,DDX23,RC3H1,CELF1,SF3A2,PIH1D1,PRMT
al_p 5,PUM2,DDX6,BICD1,PLD6,ERAL1,SRSF10,KLC1,CIRBP,NCBP2,TGS1
roce ,SNRPE
ss
2.28
349
703
3
negative regulation of macromolecule
metabolic process
biol
ogic
al_p
roce
ss
1.31
393
871
7
COL9A1,COL2A1,COL12A1,COL9A3
KANK2,EIF2B4,PSMB10,IGF1R,TNRC6A,SIRT2,NOC2L,SFSWAP,SIN3
B,CBX5,SUPT5H,UBXN1,BCL6,TBX2,CUX1,EED,FMR1,SMAD7,USP4,
HDAC6,GLG1,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,PSMB9,USP47
,DNAJC10,PCGF6,PTPN6,IGBP1,ANAPC4,PLK1,HDGF,ZC3H12A,CLN8
,TBX18,DR1,BCLAF1,GIGYF2,WAC,ZNF540,FGFR1,HSF4,CAPRIN1,C
9.00
450
856
6
1.49
933
906
9
7
E
0
4
3.
9
7
E
0
4
4.
0
5
E
0
4
4.
0
7
E
0
4
4.
2
5
E
-
5
G
O:
00
16
31
0
G
O:
00
48
66
phosphorylation
cell morphogenesis involved in neuron
differentiation
ELF1,PAF1,RNF8,MDM2,PPM1F,YY1,PFDN5,CREB1,SRP9,PTPRK,NF
1,ZEB1,IFITM3,RPS6KA5,NIPBL,RB1,PRMT5,ZFPM2,RNF168,CHMP1A
,SH3BP5,ZNF263,RGS3,NR1H3,GRB10,FLCN,VPS72,PTEN,FYN,RUN
X2,FBXW7,NCOR1,MEF2A,PRKRIP1,SETD8,UPK3B,TRIM28,PTPRC,P
SMC6,UBP1,ZNF148,PSMC4,STAG2,TCF4,ACD,SEMA4D,PIWIL4,SRS
F10,SMAD4,C1QTNF3,CREBZF,ING4,CD276,FLNA,GLI3,ENG,SIRT7,G
APDH,ERCC1,PHF1,WWP1,PHF12,MDFI,CIRBP,RGS2,HINFP,NCBP2,
MLX,GLIS3,SMARCA4,PER3,GSK3A,NCOR2,PHF21A,PDCD4,CRIPAK,
PSMA1,STAT6,CDK5RAP1,SPRED1,DUSP6,ZBTB16,BAZ2A,RRP8,LM
CD1,PDPK1,TSG101,PABPC1,UBR5,WNK1,CC2D1A,GATA2
CDK14,ACADVL,CKB,IGF1R,GK5,SIRT2,RAF1,CDK13,BDNF,TAZ,ST3
GAL1,CMPK2,ZFP91,CNTF,EEF2K,VAPB,SMAD7,VRK2,DGKA,PNKP,R
BPMS,XBP1,MARK4,UHMK1,ADAM8,DNAJC10,MINK1,PTPN6,CSNK2
A1,NOD1,PRKACA,PLK1,ASNS,HDGF,PDXK,CCNL1,FAM58A,CAMK2D
,GALK2,TNK2,STK4,ALDH18A1,FGFR1,ADCY4,TAB2,SGK1,CHKB,NA
DK,SEC31A,FKBP1A,PRKCH,PPM1F,CREB1,NPTN,NAGK,CCNL2,NF1
biol ,NEK3,NPR1,RPS6KA5,PKD2,LMNA,RB1,HMGXB3,LTBP4,MAPK8IP3,
ogic MARK3,SENP2,TPP1,STK38L,SH3BP5,RGS3,GRB10,PLK2,FLCN,NRP
al_p 1,MAST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,HERPUD1,IKBKB,PXN,F
roce ECH,PRKRIP1,STK19,MAPK8,MYLK,USP15,TRIM28,MAP4K4,CSK,PT
ss
PRC,CDK6,AAK1,PHKG2,PAK1,NCK2,TRPM7,SEMA4D,CSF1R,ERC1,
DGKZ,C3,SMAD4,DTYMK,CLK3,NDUFV1,MAPK12,NDUFS2,AK5,ENG,
NOX4,NRBP2,STK36,PDIA5,MDFI,ITGA5,RGS2,PDGFRB,CDK11A,CA
RD14,TNFRSF14,MKNK2,YIF1A,CLK4,TLN1,ADRBK2,GSK3A,SIK3,TW
F1,PRPF4B,IGF2,PSTK,PDCD4,CRIPAK,CSNK1E,CDK5RAP1,NTRK1,
SPRED1,TNFRSF10B,PHKG1,SMAD9,DUSP6,TGFBR3,UCK1,UQCRH,
PKD1,PDPK1,STK24,CDK5RAP3,GAK,RBKS,PANK3,FASTK,WNK1
biol FZD6,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,ARHGEF12,CD72,I
ogic TGA9,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,CSNK2A1,SLC11A
al_p 2,CNP,FGFR1,CAPRIN1,SSH2,CREB1,RGMB,RPS6KA5,RB1,MAPK8IP
roce 3,PAFAH1B1,USP33,HEXA,NRP1,PTEN,FYN,SRGAP2,MEF2A,TCTN1,
ss
CACNB1,MYCBP2,RAB8A,COL9A3,PTPRC,FLOT1,RANBP9,PAK1,NCK
0
4
1.28
543
232
7
4.
4
3
E
0
4
1.51
771
423
2
4.
6
6
E
-
7
G
O:
00
50
85
2
G
O:
00
00
37
7
G
O:
00
00
39
8
G
O:
00
06
47
0
2,RAB10,SEMA6A,SEMA4D,ROBO3,EZR,GLI3,EXT1,TBCE,UNC5B,PT
PRD,ITGA5,FARP1,KIF13B,TLN1,ROBO2,CACNB3,NTRK1,STK24,SSH
1,CLASP1
0
4
T cell receptor signaling pathway
biol
ogic BTN3A1,HLA-DPB1,PTPN22,HLAal_p DQA1,PTPN6,VASP,RC3H1,TAB2,LCP2,PTEN,FYN,PHPT1,IKBKB,CSK
roce ,PTPRC,PAK1,CACNB3,PDPK1
ss
2.37
752
338
1
RNA splicing, via transesterification
reactions with bulged adenosine as
nucleophile
biol
ogic
al_p
roce
ss
SFSWAP,CDK13,SART1,CLNS1A,SNRNP70,DDX23,DDX39A,SUGP1,D
HX9,EFTUD2,PRPF3,CELF1,SF3A2,HNRNPA3,PRMT5,SRPK1,CSTF1,
DDX41,SRRM2,SKIV2L2,PRPF8,HNRNPL,HNRNPH3,SRSF10,NCBP2,
TGS1,SNRPE,PRPF4B,PABPC1,PABPN1
1.90
650
459
8
mRNA splicing, via spliceosome
biol
ogic
al_p
roce
ss
SFSWAP,CDK13,SART1,CLNS1A,SNRNP70,DDX23,DDX39A,SUGP1,D
HX9,EFTUD2,PRPF3,CELF1,SF3A2,HNRNPA3,PRMT5,SRPK1,CSTF1,
DDX41,SRRM2,SKIV2L2,PRPF8,HNRNPL,HNRNPH3,SRSF10,NCBP2,
TGS1,SNRPE,PRPF4B,PABPC1,PABPN1
1.90
650
459
8
protein dephosphorylation
biol
ogic PTPN22,PTPN6,IGBP1,PPP5C,SYMPK,PPM1F,SSH2,RPRD1A,PTPRK,
al_p MDP1,MTMR14,PTEN,PHPT1,PTP4A2,PTPRF,SMEK1,PTPRS,PTPRC,
roce TIMM50,CDC14B,PTPRD,PTPN4,PTPN23,DUSP6,SSH1,EYA2
ss
2.01
315
198
2
4.
7
2
E
0
4
4.
7
3
E
0
4
4.
7
3
E
0
4
4.
7
7
E
0
4
G
O:
00
48
52
3
G
O:
00
negative regulation of cellular process
microtubule organizing center
FZD6,CRBN,KANK2,ACADVL,EIF2B4,PSMB10,CLMN,IGF1R,LAMB1,N
PHP3,TNRC6A,SIRT2,NOC2L,RAF1,LEPRE1,PPP1R13B,GAS8,SFSWA
P,BDNF,SIN3B,CBX5,SART1,COL2A1,SUPT5H,MARCH5,UBXN1,DPP4
,BCL6,TBX2,PTPN22,CNTF,CUX1,EED,FMR1,SMAD7,USP4,HDAC6,G
LG1,ARHGEF12,EHMT1,ZNF496,HGS,LANCL2,SYTL4,LEF1,PAX8,SUP
T4H1,PSMB9,ADAMTS1,NISCH,UHMK1,USP47,ADAM8,NOL3,CAPZB,
DNAJC10,CD9,PCGF6,KRIT1,PTPN6,LHX4,CSNK2A1,IGBP1,PRKACA,
ANAPC4,PLK1,ASNS,HDGF,RC3H1,NPC1,ZC3H12A,CLN8,TBX18,DR1
,BCLAF1,JAM2,GIGYF2,TBC1D14,WAC,STK4,TRO,ZNF540,FGFR1,HS
F4,CAPRIN1,CELF1,PAF1,TCHP,RNF8,MDM2,RHBDD1,FKBP1A,PRKC
H,PPM1F,YY1,PFDN5,CREB1,SRP9,PTPRK,SNX13,DFNA5,RHBDF1,N
F1,ZEB1,IFITM3,COL18A1,MED28,NPR1,RPS6KA5,G3BP1,NIPBL,PKD
biol 2,CASP2,MITF,RB1,PRMT5,ZFPM2,TXNDC5,RNF168,PAFAH1B1,SLFN
ogic 11,CHMP1A,ANXA5,SH3BP5,ZNF263,BICD1,RGS3,NR1H3,GRB10,PLK
al_p 2,FLCN,NRP1,CUL4A,CHFR,TENC1,IGFBP6,FAP,VPS72,PTEN,FYN,S
roce RPK1,RUNX2,IQGAP1,FBXW7,PHPT1,LGMN,RQCD1,SRGAP2,NCOR1
ss
,MEF2A,PRKRIP1,SETD8,PIAS2,VILL,MAPK8,USP15,TRIM28,CSK,CD
K5RAP2,PTPRC,PSMC6,TBCD,UBP1,CDK6,WDR61,ZNF148,PSMC4,S
GSM3,STAG2,GOPC,PAK1,NCK2,LEPROT,RHEB,CTSH,TCF4,ACD,SE
MA4D,DGKZ,SRSF10,SMAD4,C1QTNF3,TGFB1I1,CREBZF,ING4,CD27
6,CDC14B,LRPAP1,ATP5A1,GLI3,MAPK12,EPS15L1,EPN1,ENG,SIRT7
,NOX4,GAPDH,ERCC1,PHF1,BICC1,NRBP2,WWP1,ARHGEF7,PHF12,
MED6,UNC5B,MDFI,CIRBP,ITGA5,RGS2,HINFP,STAM2,LPCAT1,MLX,
GLIS3,TNFRSF14,DBF4,RUNX1,SMARCA4,RHBDF2,PER3,CD164,AD
RBK2,GSK3A,ANKRD6,NCOR2,TWF1,PPAP2A,PTGIS,PHF21A,PDCD4
,SNX14,CRIPAK,PSMA1,STAT6,ROBO2,CSNK1E,SON,PMP22,CLIC4,C
DK5RAP1,BNIP2,NTRK1,SPRED1,DUSP6,TGFBR3,ZBTB16,BAZ2A,RR
P8,LMCD1,PKD1,PDPK1,TSG101,FOXC1,DDAH2,STK24,PABPC1,UBR
5,WNK1,CLASP1,CC2D1A,PLA2G16,GATA2,BCL2L2
cell GAS8,SYTL4,STARD9,CEP135,MARK4,RANBP1,PRKACA,DHX9,PLK1,
ular SDCCAG8,TTC19,HERC2,CCDC14,PDE4D,DPF2,TCHP,KIAA0586,ZFY
_co VE26,DIS3L,FLII,PKD2,PPP2R3C,GNAI1,PAFAH1B1,CHMP1A,PLK2,C
1.19
837
431
9
4.
8
3
E
0
4
1.57
389
167
5.
4
0
05
81
5
G
O:
00
15
03
1
G
O:
00
16
56
7
G
O:
00
32
50
7
protein transport
protein ubiquitination
maintenance of protein location in cell
mpo EP112,SMEK1,TCTN1,ABCA2,RAB8A,CSK,CDK5RAP2,DDHD2,FLOT1,
nent WDR35,EVC,SMAD4,EZR,AK5,PHF1,HAUS5,DZIP1,CC2D2A,YIF1A,PT
PN23,TLN1,TTLL11,DYNC1I2,PSMA1,CLIC4,BNIP2,C2CD3,CLASP1,C
C2D1A
RAB3GAP2,CADM1,BTN3A1,NLRP1,CCDC91,RAB34,BCL6,NUP98,HD
AC6,ATP6V1D,HGS,DERL2,SYTL4,RBPMS,COG4,PAM,AP3S2,UHMK1
,ADAM8,RAB35,KPNA6,PRKACA,VPS52,LMAN2,NUTF2,DNM1L,HERC
2,NUP210,RAB24,ATG4B,VAMP7,BBS1,VTI1A,HPS4,RAB18,DISP1,TIM
M23,SEC31A,MDM2,SNAP23,SFT2D2,MCFD2,SRP9,DDX58,RPL27,LC
biol
P2,SNX13,AP4B1,RHBDF1,SNX21,NF1,RPL9,RAB31,PKD2,LMNA,STX
ogic
16,PAFAH1B1,SENP2,SYTL2,CHMP1A,GCC2,NR1H3,RPL24,RPL37A,
al_p
STX2,SNX17,KPNB1,PPP1R10,NECAB3,CACNB1,CLTCL1,RAB8A,DE
roce
NND4C,CSK,STX18,NUP37,CLTB,GOPC,RAB10,VPS45,ACD,CSF1R,A
ss
TP6V0A1,ERC1,TIMM50,OS9,TMED3,SMAD4,GRPEL2,C1QTNF3,RPL4
,FLNA,RAB5A,GLI3,TMED2,MCOLN1,SCFD1,VTI1B,SLC25A6,VAMP4,
MDFI,NUP85,STAM2,VPS51,CANX,YIF1A,RPLP0,SDAD1,SNX27,KIF13
B,RHBDF2,ATG4A,PDIA3,ATG16L2,SNX14,LONP2,ATG3,LMF1,SEC31
B,SPCS3,PKD1,TSG101,KPNA1,SCAMP1,UBR5,GORASP1
CRBN,PSMB10,PPIL2,SPOP,MARCH5,UBXN1,FBXO32,ZFP91,SMAD7,
USP4,HDAC6,PSMB9,APITD1,RNF220,MARCH6,ANAPC4,PLK1,RC3H
biol
1,HERC2,SEPT4,MIB2,PCGF1,DCAF11,WAC,PAF1,SHARPIN,RNF8,M
ogic
DM2,FKBP1A,ANAPC16,NUB1,SPSB3,UNKL,DCAF8,UBE2Q1,UBAC1,
al_p
RNF168,RNF217,CUL4A,CHFR,PTEN,FBXW7,HERPUD1,MYCBP2,RN
roce
F213,TRIM28,PSMC6,RNF146,PSMC4,OS9,ASB8,CDCA3,CDC14B,DC
ss
AF6,WWP1,UBA6,TRIM41,DCAF17,KLHL7,FBXW2,AMFR,PSMA1,SHP
RH,ATG3,ZBTB16,UBR5
biol
ogic
GPAA1,TLN2,PKD2,RB1,SYNE1,BICD1,GCC2,GOPC,OS9,EZR,FLNA,S
al_p
UN2,MDFI,TLN1,PDIA3,PKD1,CLASP1
roce
ss
2
E
0
4
1.32
208
075
9
6.
0
1
E
0
4
1.49
444
326
8
6.
4
1
E
0
4
2.38
577
867
1
6.
4
4
E
0
4
G
O:
00
09
89
2
G
O:
00
34
62
0
G
O:
00
00
37
5
negative regulation of metabolic process
KANK2,ACADVL,EIF2B4,PSMB10,IGF1R,TNRC6A,SIRT2,NOC2L,SFS
WAP,SIN3B,CBX5,SUPT5H,UBXN1,BCL6,TBX2,CUX1,EED,FMR1,SMA
D7,USP4,HDAC6,GLG1,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,PSM
B9,USP47,DNAJC10,PCGF6,PTPN6,IGBP1,ANAPC4,PLK1,HDGF,NPC
1,ZC3H12A,CLN8,TBX18,DR1,BCLAF1,GIGYF2,TBC1D14,WAC,ZNF54
0,FGFR1,HSF4,CAPRIN1,CELF1,PAF1,RNF8,MDM2,PPM1F,YY1,PFDN
biol
5,CREB1,SRP9,PTPRK,NF1,ZEB1,IFITM3,RPS6KA5,NIPBL,RB1,PRMT
ogic
5,ZFPM2,RNF168,CHMP1A,SH3BP5,ZNF263,RGS3,NR1H3,GRB10,FL
al_p
CN,VPS72,PTEN,FYN,RUNX2,IQGAP1,FBXW7,NCOR1,MEF2A,PRKRI
roce
P1,SETD8,UPK3B,TRIM28,PTPRC,PSMC6,UBP1,ZNF148,PSMC4,STA
ss
G2,TCF4,ACD,SEMA4D,PIWIL4,SRSF10,SMAD4,C1QTNF3,CREBZF,IN
G4,CD276,FLNA,GLI3,ENG,SIRT7,GAPDH,ERCC1,PHF1,NRBP2,WWP
1,PHF12,MDFI,CIRBP,RGS2,HINFP,NCBP2,LPCAT1,MLX,GLIS3,SMAR
CA4,PER3,GSK3A,NCOR2,PTGIS,PHF21A,PDCD4,CRIPAK,PSMA1,ST
AT6,CDK5RAP1,SPRED1,DUSP6,ZBTB16,BAZ2A,RRP8,LMCD1,PDPK
1,TSG101,PABPC1,UBR5,WNK1,CC2D1A,GATA2
cellular response to unfolded protein
biol
ogic
ACADVL,VAPB,DERL2,XBP1,ASNS,HDGF,SEC31A,RHBDD1,LMNA,TP
al_p
P1,HERPUD1,PDIA5,YIF1A,TLN1,GSK3A,AMFR
roce
ss
2.44
956
954
4
RNA splicing, via transesterification
reactions
biol
ogic
al_p
roce
ss
1.86
257
592
1
SFSWAP,CDK13,SART1,CLNS1A,SNRNP70,DDX23,DDX39A,SUGP1,D
HX9,EFTUD2,PRPF3,CELF1,SF3A2,HNRNPA3,PRMT5,SRPK1,CSTF1,
DDX41,SRRM2,SKIV2L2,PRPF8,HNRNPL,HNRNPH3,SRSF10,NCBP2,
TGS1,SNRPE,PRPF4B,PABPC1,PABPN1
1.29
031
156
6
6.
6
1
E
0
4
6.
8
2
E
0
4
7.
0
1
E
0
4
G
O:
00
06
98
7
G
O:
00
34
97
6
G
O:
00
16
07
0
activation of signaling protein activity
involved in unfolded protein response
biol
ogic
ACADVL,VAPB,XBP1,ASNS,HDGF,SEC31A,LMNA,TPP1,HERPUD1,PD
al_p
IA5,YIF1A,TLN1,GSK3A
roce
ss
2.73
662
847
5
response to endoplasmic reticulum stress
biol
ogic ACADVL,VAPB,DERL2,BCL2L11,XBP1,DNAJC10,ASNS,HDGF,SEC31A
al_p ,LMNA,TPP1,HERPUD1,OS9,PDIA5,YIF1A,TLN1,GSK3A,AMFR,TNFRS
roce F10B
ss
2.22
591
319
5
RNA metabolic process
FZD6,RNASEH2B,PBX2,KANK2,GTF3C2,RAI1,PSMB10,XRN1,SIRT2,M
YNN,NOC2L,TARS,ZNF131,RSC1A1,SFSWAP,CDK13,RBM6,SIN3B,CB
X5,SART1,SUPT5H,SUPT20H,PWP1,BCL6,FUBP1,ZNF783,TBX2,MMS
19,CUX1,RBM17,CLNS1A,EED,SMAD7,MCF2L,HDAC6,EHMT1,RNH1,Z
NF496,TYW1B,NARS,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,E
MX2,RBPMS,ZSCAN31,XBP1,PAM,NOM1,SNRNP70,DDX23,METTL3,A
PITD1,USP47,ADAM8,NOL3,POLR3E,GABPB1,PRPF40A,PCGF6,DDX3
biol
9A,SUGP1,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,STAT2,RPP1
ogic
4,DHX9,PLK1,ZNF446,PTGES2,UPF1,ZNF621,HDGF,RC3H1,PPP5C,C
al_p
CNL1,CHD6,ZC3H12A,SYMPK,EFTUD2,FAM58A,CNP,TBX18,LBX2,PC
roce
GF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,PRPF3,WAC,ZNF
ss
142,FUBP3,RARS,ZNF540,FGFR1,HSF4,PAIP1,GTF3C1,CELF1,RNAS
ET2,SF3A2,PAF1,TAB2,SGK1,DPF2,MDM2,PRKCH,PPM1F,ZNF595,TB
P,DIS3L,YY1,INO80,GMEB2,PFDN5,CREB1,FLII,RPRD1A,DDX58,RPL2
7,CCNL2,PTPRK,ZEB1,EIF4B,IFITM3,ASCC2,RGMB,EBF1,RPL9,MED2
8,ZNF3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,HNRNPA3,RXRB,LMNA,
MITF,NOL8,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,ZNF865,SENP2,SUB1
,CHMP1A,PDE8A,NSA2,DDX6,ZNF558,ZNF263,ZNF180,BICD1,ZNF276
1.15
394
440
3
7.
2
3
E
0
4
7.
7
7
E
0
4
7.
9
0
E
0
4
G
O:
00
48
52
2
positive regulation of cellular process
,NR1H3,GARS,PAN2,USP7,PLD6,FLCN,ZNF605,ZNF410,RPL24,RPL37
A,SAP30BP,VPS72,PTEN,SRPK1,RNASEK,RUNX2,CSTF1,FBXW7,INT
S4,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,PPP1R10,MEF2A,PARN,S
ETD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41,SRRM2,PBX3,ZNF565,A
BCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,PSMC6,UBP1,SKIV2L2,WDR6
1,EBF4,PRPF8,FARSA,ZNF148,ZNF76,PSMC4,HNRNPL,SP110,PPA2,
NCK2,HNRNPH3,TCF4,IKZF5,HMGN2,WDR4,SEMA4D,SSBP2,ERC1,N
FYC,PIWIL4,RPUSD4,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHURC
1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,RPL4,ZNF44,CREBZF,ING4,RB
MS1,ZNF687,CLK3,NR2C2,FHOD1,FIP1L1,DNTTIP2,FLNA,IRF9,GLI3,
MAPK12,CCDC59,DCAF6,THOC2,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,
ZNF692,PHF1,STK36,WWP1,PHF12,MED6,MDFI,ZNF554,HINFP,NCBP
2,MLX,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,SMARCA4,NAA16,LR
PPRC,RPLP0,RAD54L2,CLASRP,ZNF518B,CRCP,CLK4,ZNF90,ZNF63
8,PER3,SNRPE,ZNF383,POLR2J3,NCOR2,SETD2,PRPF4B,IGF2,PTGI
S,FTSJ3,TROVE2,ATXN3,PSTK,PHF21A,PDCD4,SOX13,CHD2,PSMA1
,STAT6,CARS2,SON,ZNF138,ZNF705A,CDK5RAP1,NTRK1,TFAM,BRW
D1,SMAD9,TGFBR3,ZFC3H1,ZBTB16,BAZ2A,RRP8,VARS,LARS,PHF1
9,LMCD1,LUC7L3,PKD1,PDPK1,TSG101,USF1,FOXC1,ARL6IP4,CDK5
RAP3,MTO1,PABPC1,FASTK,EYA2,SMARCAD1,CC2D1A,GATA2,PAB
PN1
OBFC1,PBX2,CRIP2,ACADVL,CADM1,PSMB10,IGF1R,LAMB1,UTRN,R
AF1,NLRP1,PPP1R13B,CDK13,BDNF,SART1,SUPT5H,HLADPB1,MARCH5,DPP4,BCL6,TBX2,MMS19,SHMT2,ZFP91,CNTF,VAPB,
biol
SMAD7,MCF2L,HDAC6,ZNF496,CASP4,DERL2,IL15RA,LANCL2,SYTL4
ogic
,ARPC4al_p
TTLL3,LEF1,PAX8,SUPT4H1,PSMB9,BCL2L13,BCL2L11,RBPMS,XBP1,
roce
HSD17B12,HLAss
DQA1,RAD23A,APITD1,MARK4,UHMK1,USP47,ADAM8,GABPB1,RANB
P1,MINK1,PTPN6,ACTR3,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,AN
APC4,PLK1,ASNS,DNM1L,PTGES2,HDGF,PPP5C,SHISA5,ZC3H12A,S
1.17
706
104
3
8.
2
4
E
0
4
EPT4,MIB2,SYMPK,AAMP,ATG4B,TBX18,BCLAF1,JHDM1D,TNK2,WA
C,STK4,FUBP3,FGFR1,HSF4,DISP1,PAIP1,CAPRIN1,ADCY4,PAF1,TA
B2,SHARPIN,DPF2,RNF8,SEC31A,MDM2,FKBP1A,PRKCH,PPM1F,TB
P,INO80,CREB1,NPTN,TNFRSF25,PLEKHG5,DDX58,DFNA5,NF1,ZEB1
,NUB1,IFITM3,RGMB,COL18A1,EBF1,NPR1,RPS6KA5,NIPBL,CAPN10,
PKD2,CASP2,RXRB,LMNA,MITF,NOL8,RB1,MAPK8IP3,PLEKHA2,ZFP
M2,TP53BP1,BLOC1S5,RNF168,PAFAH1B1,SENP2,IL18,MTCH1,TPP1,
AACS,ARPC2,BICD1,NR1H3,GRB10,PLK2,FLCN,NRP1,CUL4A,SAP30
BP,PTEN,FYN,ALDH1A3,SRPK1,RUNX2,IQGAP1,FBXW7,PHPT1,SMA
RCD3,HERPUD1,IKBKB,PXN,LTBR,NCOR1,MEF2A,OXCT1,LIFR,SME
K1,WASH4P,PIAS2,MAPK8,SH3BP2,MYLK,DDX41,N6AMT1,TRIM28,C
SK,CDK5RAP2,PTPRC,PSMC6,RNF146,CDK6,ABI3BP,RARRES2,WDR
61,ZNF148,PSMC4,AAK1,PHKG2,PAK1,EVC,NCK2,RHEB,SEMA6A,CT
SH,TCF4,SEMA4D,CSF1R,ACTR2,C3,NFYC,SS18,SMAD4,CHURC1,C
HURC1FNTB,C1QTNF3,TGFB1I1,DDAH1,GOLPH3,ING4,CD276,CDC14B,NR2
C2,FHOD1,APOL3,FLNA,RAB5A,SUN2,GLI3,MAPK12,DCAF6,ENG,SIR
T7,TCF12,ARNT,NOX4,PHF1,TEX261,STK36,ARHGEF7,PDIA5,MED6,
MDFI,CIRBP,CIZ1,PTPRD,ITGA5,HINFP,NCBP2,MLX,PDGFRB,COL8A
1,LGALS8,GLIS3,ELP6,CARD14,DIABLO,TNFRSF14,RUNX1,SMARCA
4,NAA16,YIF1A,TLN1,GSK3A,ANKRD6,NLGN2,PDIA3,IGF2,PTGIS,PS
MA1,STAT6,ACIN1,ROBO2,CSNK1E,NSMCE4A,BNIP2,NTRK1,TFAM,S
PRED1,TNFRSF10B,SMAD9,HBB,DUSP6,TGFBR3,ZBTB16,RRP8,PHF
19,LMCD1,PKD1,PDPK1,USF1,FOXC1,DDAH2,STK24,CDK5RAP3,PAB
PC1,UBR5,SMARCAD1,CC2D1A,TENM4,GATA2
G
O:
00
03
68
2
chromatin binding
mol
ecul
ar_f
unct
ion
PBX2,NOC2L,SIN3B,CBX5,BCL6,SHMT2,CUX1,EED,LEF1,APITD1,UPF
1,CHD6,WAC,PAF1,RNF8,ZEB1,NIPBL,MITF,PRMT5,RNF168,SENP2,
MUM1,RUNX2,NCOR1,MEF2A,SSBP1,DMTF1,HMGN2,RCOR3,SMAD4
,MIER2,GLI3,SIRT7,HINFP,BDP1,SMARCA4,POLG,NCOR2,PHF21A,TF
AM,FOXC1,GATA2
1.65
388
932
8
8.
7
1
E
0
4
G
O:
00
10
60
8
G
O:
00
48
51
8
posttranscriptional regulation of gene
expression
biol
ogic
al_p
roce
ss
EIF2B4,TNRC6A,TRNAU1AP,FMR1,SMAD7,USP4,UHMK1,UPF3A,DHX
9,PLK1,UPF1,RC3H1,GIGYF2,ZNF540,HPS4,PAIP1,CAPRIN1,CELF1,R
NF8,MDM2,CREB1,SRP9,EIF4B,SERBP1,USP3,RNF168,PUM2,PTEN,F
BXW7,FECH,AAK1,NCK2,CTSH,ZSWIM7,PIWIL4,FLNA,GAPDH,CIRBP,
RGS2,NCBP2,MKNK2,PSTK,VARS,LARS,PABPC1
positive regulation of biological process
OBFC1,PBX2,CRIP2,ACADVL,CADM1,PSMB10,IGF1R,LAMB1,EPHX2,
UTRN,BTN3A1,RAF1,NLRP1,PPP1R13B,CDK13,BDNF,SART1,SUPT5
H,HLADPB1,MARCH5,DPP4,BCL6,FUBP1,TBX2,PTPN22,MMS19,SHMT2,ZFP
91,CNTF,VAPB,SMAD7,MCF2L,HDAC6,ZNF496,CASP4,DERL2,IL15RA
,LANCL2,SYTL4,ARPC4TTLL3,LEF1,PAX8,SUPT4H1,PSMB9,BCL2L13,BCL2L11,RBPMS,XBP1,
HSD17B12,HLADQA1,RAD23A,APITD1,MARK4,UHMK1,USP47,ADAM8,GABPB1,RANB
P1,MINK1,PTPN6,ACTR3,VASP,CSNK2A1,IGBP1,UPF3A,NOD1,PRKA
biol CA,ANAPC4,PLK1,ASNS,DNM1L,PTGES2,HDGF,RC3H1,PPP5C,SHIS
ogic A5,ZC3H12A,SEPT4,MIB2,SYMPK,AAMP,ATG4B,TBX18,BCLAF1,CAM
al_p K2D,JHDM1D,TNK2,WAC,STK4,FUBP3,FGFR1,HPS4,HSF4,C2,CFB,DI
roce SP1,PAIP1,CAPRIN1,ADCY4,CELF1,PAF1,TAB2,SGK1,SHARPIN,DPF2
ss
,RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,PRKCH,PPM1F,TBP,INO80,C
REB1,NPTN,TNFRSF25,PLEKHG5,DDX58,LCP2,DFNA5,NF1,ZEB1,NU
B1,IFITM3,RGMB,COL18A1,EBF1,NPR1,RPS6KA5,NIPBL,CAPN10,PK
D2,CASP2,RXRB,LMNA,MITF,NOL8,RB1,MAPK8IP3,PLEKHA2,ZFPM2,
TP53BP1,BLOC1S5,RNF168,PAFAH1B1,SENP2,IL18,MTCH1,TPP1,AA
CS,ARPC2,BICD1,NR1H3,GRB10,PLK2,FLCN,NRP1,CUL4A,SAP30BP,
PTEN,FYN,ALDH1A3,SRPK1,RUNX2,IQGAP1,C1R,FBXW7,PHPT1,SM
ARCD3,HERPUD1,IKBKB,PXN,LTBR,NCOR1,MEF2A,OXCT1,LIFR,SM
EK1,WASH4P,PIAS2,MAPK8,SH3BP2,CLTCL1,MYLK,DDX41,N6AMT1,
TRIM28,CSK,CDK5RAP2,PTPRC,PSMC6,RNF146,CDK6,ABI3BP,RARR
ES2,WDR61,ZNF148,PSMC4,SGSM3,AAK1,PHKG2,PAK1,EVC,NCK2,R
1.62
103
866
9
8.
9
0
E
0
4
1.16
503
917
3
8.
9
7
E
0
4
G
O:
00
34
65
5
nucleobase-containing compound catabolic
process
G
O:
coenzyme binding
HEB,SEMA6A,CTSH,TCF4,SEMA4D,CSF1R,ACTR2,C3,NFYC,SS18,S
MAD4,CHURC1,CHURC1FNTB,C1QTNF3,TGFB1I1,DDAH1,GOLPH3,ING4,CD276,CDC14B,NR2
C2,FHOD1,APOL3,FLNA,RAB5A,SUN2,C1S,GLI3,TMED2,MAPK12,DC
AF6,ENG,SIRT7,TCF12,ARNT,NOX4,PHF1,TEX261,SLC25A6,STK36,A
RHGEF7,PDIA5,MED6,MDFI,CIRBP,CIZ1,PTPRD,ITGA5,RGS2,HINFP,
NCBP2,LPCAT1,MLX,PDGFRB,COL8A1,LGALS8,GLIS3,ELP6,CARD14,
DIABLO,TNFRSF14,RUNX1,SMARCA4,NAA16,YIF1A,TLN1,FGF14,GS
K3A,ANKRD6,NLGN2,PDIA3,IGF2,PTGIS,PSMA1,STAT6,ACIN1,ROBO
2,CSNK1E,CACNB3,NSMCE4A,BNIP2,NTRK1,TFAM,SPRED1,TNFRSF
10B,SMAD9,HBB,DUSP6,TGFBR3,ZBTB16,RRP8,PHF19,LMCD1,PKD1
,PDPK1,USF1,FOXC1,KPNA1,DDAH2,STK24,CDK5RAP3,PABPC1,UB
R5,SMARCAD1,CC2D1A,TENM4,GATA2
RNASEH2B,CRBN,RAB3GAP2,DHX34,EIF2B4,XRN1,MYO1D,RALGAP
A2,SEPT5,ATP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,R
NH1,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB
35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,UP
F3A,DHX9,PDE7B,TBC1D2B,DNM1L,UPF1,RC3H1,HERC2,CHD6,TBC1
D10B,SEPT4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB18,PAIP1,
biol PMS1,PDE4D,RNASET2,PLEKHG4,DIS3L,FAM13A,INO80,RALGPS2,P
ogic LEKHG5,DDX58,RPL27,SNX13,NF1,EIF4B,RTKN,RPL9,G3BP1,RAB31,
al_p GALT,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,PAN2,RP
roce L24,ARHGAP9,RPL37A,IQGAP1,RQCD1,KPNB1,SRGAP2,ATP11B,PA
ss
RN,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SK
IV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPE
L2,TBC1D22A,RPL4,RAB5A,ATP5A1,TMED2,RASGRF2,ERCC1,ATP8B
2,ARHGEF7,ASAP1,RGS2,NCBP2,RAD51B,FARP1,RAP1B,SMARCA4,
RPLP0,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,KPNA1,RAPGEF6,PABPC1,SMARCA
D1,DENND6B
mol ACADVL,SIRT2,TYW1B,H6PD,PNPO,FDXR,GCDH,IDH3G,ALDH6A1,A
ecul CBD4,FMO2,GMDS,ALDH1A3,IDH1,MTRR,NDUFV1,NDUFS2,SIRT7,N
1.28
748
706
4
8.
9
9
E
0
4
1.92
953
9.
1
00
50
66
2
G
O:
00
10
49
4
G
O:
00
06
89
3
G
O:
00
17
11
1
ar_f
unct
ion
OX4,ETFA,GAPDH,SDHA,IDH3B,D2HGDH,SIRT3,MTO1
755
cytoplasmic stress granule
cell
ular
_co FMR1,RC3H1,CAPRIN1,G3BP1,PUM2,DDX6,CIRBP,PABPC1
mpo
nent
3.73
155
407
3
Golgi to plasma membrane transport
biol
ogic
al_p VAMP7,BBS1,RAB31,GCC2,CSK,GOPC,RAB10,VAMP4
roce
ss
3.71
658
827
4
nucleoside-triphosphatase activity
mol
ecul
ar_f
unct
ion
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,ERCC6L2,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,DYNC1I1,
ARHGEF25,RGL4,STARD13,STARD9,ABCC1,DDX23,DNAJC10,RAB35
,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX
9,TBC1D2B,DNM1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,T
BC1D14,TNK2,GIT2,MTG1,RAB18,PMS1,PLEKHG4,FAM13A,INO80,RA
LGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,NTPCR,GN
AI1,PAFAH1B1,DNALI1,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP
1,SRGAP2,ATP11B,SSBP1,DDX41,RNF213,ABCA2,DENND4C,MAP4K
4,PSMC6,TBCD,SKIV2L2,PSMC4,KIFC2,ARHGAP29,SGSM3,GOPC,RH
EB,SEMA4D,GNB3,GRPEL2,TBC1D22A,KLC1,NAV1,DNHD1,RAB5A,B
CS1L,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,NUBP1,R
GS2,RAD51B,MYO7B,FARP1,RAP1B,SMARCA4,DHX40,RAD54L2,KIF1
1.30
510
131
8
4
E
0
4
9.
4
0
E
0
4
9.
4
3
E
0
4
9.
7
0
E
0
4
3B,DOCK8,LONRF3,MYO1E,DYNC1I2,RGL2,CHD2,LONP2,ACIN1,PSD
3,BNIP2,NTRK1,SHPRH,DHX37,RAPGEF6,SMARCAD1,DENND6B
G
O:
00
32
07
5
G
O:
00
34
64
4
G
O:
00
18
90
4
G
O:
00
45
18
4
positive regulation of nuclease activity
biol
ogic
ACADVL,VAPB,XBP1,ASNS,HDGF,SEC31A,LMNA,TPP1,HERPUD1,PD
al_p
IA5,YIF1A,TLN1,GSK3A
roce
ss
2.65
370
034
cellular response to UV
biol
ogic
al_p NOC2L,USP47,MDM2,RHBDD1,YY1,INO80,PTPRK,CRIP1,FBXW7
roce
ss
3.36
815
812
3
ether metabolic process
biol
ogic
al_p DNAJC10,TXNL1,QSOX1,TXNDC5,P4HB,PDIA5,PDIA3
roce
ss
4.10
036
641
1
establishment of protein localization
RAB3GAP2,CADM1,BTN3A1,NLRP1,CCDC91,RAB34,BCL6,NUP98,HD
AC6,ATP6V1D,HGS,DERL2,SYTL4,RBPMS,COG4,PAM,AP3S2,UHMK1
biol ,ADAM8,RAB35,KPNA6,PRKACA,VPS52,LMAN2,NUTF2,DNM1L,HERC
ogic 2,NUP210,RAB24,ATG4B,VAMP7,BBS1,VTI1A,HPS4,RAB18,DISP1,TIM
al_p M23,SEC31A,MDM2,SNAP23,SFT2D2,MCFD2,SRP9,DDX58,RPL27,LC
roce P2,SNX13,AP4B1,RHBDF1,SNX21,NF1,RPL9,RAB31,PKD2,LMNA,STX
ss
16,PAFAH1B1,SENP2,SYTL2,CHMP1A,GCC2,NR1H3,RPL24,RPL37A,
STX2,SNX17,KPNB1,PPP1R10,NECAB3,CACNB1,CLTCL1,RAB8A,DE
NND4C,CSK,STX18,NUP37,CLTB,GOPC,RAB10,VPS45,ACD,CSF1R,A
1.29
856
698
7
9.
8
0
E
0
4
9.
9
9
E
0
4
1.
0
4
E
0
3
1.
0
9
E
0
3
G
O:
00
31
98
2
G
O:
00
45
74
9
G
O:
00
16
81
8
vesicle
TP6V0A1,ERC1,TIMM50,OS9,TMED3,SMAD4,GRPEL2,C1QTNF3,RPL4
,FLNA,RAB5A,GLI3,TMED2,MCOLN1,SCFD1,VTI1B,SLC25A6,VAMP4,
MDFI,NUP85,HINFP,STAM2,VPS51,CANX,YIF1A,RPLP0,SDAD1,SNX2
7,KIF13B,RHBDF2,ATG4A,PDIA3,ATG16L2,SNX14,LONP2,ATG3,LMF1
,SEC31B,SPCS3,PKD1,PDPK1,TSG101,KPNA1,SCAMP1,UBR5,GORA
SP1
CADM1,LAMB1,SEPT5,BDNF,CPE,RAB34,HLADPB1,DPP4,DYNC1I1,HGS,IL15RA,SYTL4,HLAC,YIPF1,ADAMTS1,RGL4,PAM,HLADQA1,AP3S2,ADAM8,RAB35,CD9,NPC1,SLC11A2,CNP,VAMP7,CAMK
cell 2D,TNK2,FLG,VTI1A,FGFR1,HPS4,SEC31A,MDM2,SNAP23,COL12A1,
ular MCFD2,SNX21,LGALS3BP,RAB31,GNAI1,BLOC1S5,PAFAH1B1,TPP1,
_co SYTL2,EPN2,ANXA5,ADAM15,BICD1,GARS,NRP1,STX2,SNX17,GGNB
mpo P2,SRGAP2,ITGB5,CLTCL1,HLAnent F,ABCA2,RAB8A,DENND4C,CLTB,FLOT1,AAK1,GOPC,NCK2,RAB10,C
TSH,ATP6V0A1,C3,P4HB,TMED3,CLK3,LRPAP1,FLNA,RAB5A,TMED2,
VEZT,SCFD1,GAPDH,PDGFRB,VPS51,CANX,PTPN23,CRCP,TLN1,PDI
A3,MYO1E,CORO7,DPP7,DYNC1I2,CLIC4,NTRK1,CTTNBP2,SEC31B,
ZDHHC8,PDPK1,CD63
negative regulation of S phase of mitotic cell
cycle
biol
ogic
al_p BCL6,PAF1,RB1,CHMP1A,SMARCA4
roce
ss
hydrolase activity, acting on acid
anhydrides, in phosphorus-containing
anhydrides
mol
ecul
ar_f
unct
ion
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,ERCC6L2,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,DYNC1I1,
ARHGEF25,RGL4,STARD13,STARD9,ABCC1,DDX23,DNAJC10,RAB35
,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX
9,TBC1D2B,DNM1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,T
BC1D14,TNK2,GIT2,MTG1,RAB18,PMS1,PLEKHG4,FAM13A,INO80,RA
1.35
642
544
2
5.61
359
687
2
1.29
448
172
9
1.
1
2
E
0
3
1.
1
4
E
0
3
1.
1
5
E
0
LGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,NTPCR,GN
AI1,PAFAH1B1,DNALI1,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP
1,SRGAP2,ATP11B,SSBP1,DDX41,RNF213,ABCA2,DENND4C,MAP4K
4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,KIFC2,ARHGAP29,SGSM3,GO
PC,PPA2,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,KLC1,NAV1,DNH
D1,RAB5A,BCS1L,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASA
P1,NUBP1,RGS2,RAD51B,MYO7B,FARP1,RAP1B,SMARCA4,DHX40,R
AD54L2,ACYP2,KIF13B,DOCK8,LONRF3,MYO1E,DYNC1I2,RGL2,CHD
2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,SHPRH,DHX37,RAPGEF6,SMAR
CAD1,DENND6B
G
O:
00
06
41
7
G
O:
00
15
03
5
G
O:
00
51
24
8
3
regulation of translation
biol
ogic
al_p
roce
ss
protein disulfide oxidoreductase activity
mol
ecul
ar_f
unct
ion
DNAJC10,TXNL1,PTGES2,QSOX1,TXNDC5,P4HB,PDIA5,PDIA3
3.60
180
342
7
negative regulation of protein metabolic
process
biol
ogic
al_p
roce
ss
EIF2B4,PSMB10,IGF1R,TNRC6A,NOC2L,UBXN1,FMR1,SMAD7,USP4,
HDAC6,GLG1,PSMB9,DNAJC10,PTPN6,IGBP1,ANAPC4,PLK1,CLN8,GI
GYF2,WAC,ZNF540,CAPRIN1,CELF1,RNF8,MDM2,PPM1F,SRP9,NF1,
RB1,RNF168,SH3BP5,RGS3,NR1H3,PTEN,FYN,PRKRIP1,PTPRC,PSM
C6,PSMC4,SEMA4D,SMAD4,CD276,FLNA,ENG,GAPDH,PHF1,CIRBP,
RGS2,PDCD4,CRIPAK,PSMA1,CDK5RAP1,SPRED1,DUSP6,PDPK1,U
BR5,WNK1
1.50
576
480
8
EIF2B4,TNRC6A,TRNAU1AP,FMR1,UHMK1,UPF3A,UPF1,GIGYF2,ZNF
540,PAIP1,CAPRIN1,CELF1,RNF8,SRP9,EIF4B,RNF168,PUM2,FECH,N
CK2,PIWIL4,GAPDH,CIRBP,RGS2,NCBP2,MKNK2,PSTK,VARS,LARS,
PABPC1
1.82
573
057
2
1.
1
7
E
0
3
1.
1
8
E
0
3
1.
2
3
E
0
3
G
O:
00
45
18
5
G
O:
00
22
61
8
maintenance of protein location
biol
ogic
GPAA1,TLN2,PKD2,RB1,SYNE1,BICD1,GCC2,GOPC,OS9,EZR,FLNA,S
al_p
UN2,MDFI,TLN1,TWF1,PDIA3,PKD1,CLASP1
roce
ss
2.18
475
121
5
ribonucleoprotein complex assembly
biol
ogic
SFSWAP,SART1,CLNS1A,DDX23,RC3H1,CELF1,SF3A2,PIH1D1,PRMT
al_p
5,PUM2,DDX6,BICD1,ERAL1,SRSF10,CIRBP,NCBP2,TGS1,SNRPE
roce
ss
2.18
475
121
5
G
O:
00
16
81
7
hydrolase activity, acting on acid anhydrides
mol
ecul
ar_f
unct
ion
G
O:
ribonucleoprotein granule
cell
ular
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,ERCC6L2,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,DYNC1I1,
ARHGEF25,RGL4,STARD13,STARD9,ABCC1,DDX23,DNAJC10,RAB35
,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX
9,TBC1D2B,DNM1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,T
BC1D14,TNK2,GIT2,MTG1,RAB18,PMS1,PLEKHG4,FAM13A,INO80,RA
LGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,NTPCR,GN
AI1,PAFAH1B1,DNALI1,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP
1,SRGAP2,ATP11B,SSBP1,DDX41,RNF213,ABCA2,DENND4C,MAP4K
4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,KIFC2,ARHGAP29,SGSM3,GO
PC,PPA2,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,KLC1,NAV1,DNH
D1,RAB5A,BCS1L,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASA
P1,NUBP1,RGS2,RAD51B,MYO7B,FARP1,RAP1B,SMARCA4,DHX40,R
AD54L2,ACYP2,KIF13B,DOCK8,LONRF3,MYO1E,DYNC1I2,RGL2,CHD
2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,SHPRH,DHX37,RAPGEF6,SMAR
CAD1,DENND6B
XRN1,TNRC6A,FMR1,UHMK1,UPF1,RC3H1,CAPRIN1,G3BP1,PUM2,D
DX6,PAN2,RQCD1,PIWIL4,CIRBP,PABPC1
1.
3
2
E
0
3
1.
3
2
E
0
3
1.28
969
090
1
1.
3
3
E
0
3
2.38
522
1.
3
00
35
77
0
G
O:
00
34
61
3
G
O:
00
31
32
7
G
O:
20
00
11
_co
mpo
nent
cellular protein localization
negative regulation of cellular biosynthetic
process
negative regulation of cellular
macromolecule biosynthetic process
RAB3GAP2,RALGAPA2,GAS8,CPE,MARCH5,BCL6,GPAA1,NUP98,SM
AD7,USP4,HDAC6,HGS,DERL2,SYTL4,RBPMS,AP3S2,UHMK1,KPNA6,
PRKACA,PLK1,NUTF2,HERC2,VAMP7,BBS1,VTI1A,HPS4,TIMM23,MD
biol M2,TLN2,SRP9,DDX58,RPL27,PTPRK,SNX13,AP4B1,NF1,RPL9,NIPBL,
ogic RAB31,PKD2,LMNA,RB1,STX16,SYTL2,SYNE1,BICD1,GCC2,FLCN,RP
al_p L24,RPL37A,STX2,SNX17,KPNB1,PPP1R10,CACNB1,CLTCL1,DENND
roce 4C,CSK,STX18,CLTB,FLOT1,GOPC,PAK1,LEPROT,RAB10,VPS45,AC
ss
D,TIMM50,OS9,SMAD4,GRPEL2,C1QTNF3,EZR,RPL4,FLNA,SUN2,GLI
3,TMED2,VTI1B,SLC25A6,VAMP4,MDFI,STAM2,RPLP0,KIF13B,TLN1,N
LGN2,PDIA3,LONP2,CSNK1E,ATG3,SPCS3,PKD1,PDPK1,KPNA1,CD6
3,UBR5,CLASP1
KANK2,ACADVL,EIF2B4,TNRC6A,SIRT2,NOC2L,SIN3B,CBX5,SUPT5H
,BCL6,TBX2,CUX1,EED,FMR1,SMAD7,HDAC6,EHMT1,ZNF496,LANCL
2,LEF1,SUPT4H1,USP47,PCGF6,IGBP1,PLK1,HDGF,ZC3H12A,TBX18,
biol DR1,BCLAF1,GIGYF2,ZNF540,FGFR1,HSF4,CAPRIN1,CELF1,PAF1,R
ogic NF8,MDM2,PPM1F,YY1,PFDN5,CREB1,SRP9,PTPRK,ZEB1,IFITM3,RP
al_p S6KA5,NIPBL,RB1,PRMT5,ZFPM2,RNF168,CHMP1A,ZNF263,NR1H3,G
roce RB10,FLCN,VPS72,RUNX2,FBXW7,NCOR1,MEF2A,SETD8,TRIM28,UB
ss
P1,ZNF148,STAG2,TCF4,ACD,SEMA4D,SMAD4,C1QTNF3,CREBZF,IN
G4,CD276,GLI3,ENG,SIRT7,GAPDH,WWP1,PHF12,MDFI,CIRBP,HINFP
,LPCAT1,MLX,GLIS3,SMARCA4,PER3,GSK3A,NCOR2,PTGIS,PHF21A,
PDCD4,STAT6,ZBTB16,BAZ2A,RRP8,LMCD1,TSG101,CC2D1A,GATA2
biol KANK2,EIF2B4,TNRC6A,SIRT2,NOC2L,SIN3B,CBX5,SUPT5H,BCL6,TB
ogic X2,CUX1,EED,FMR1,SMAD7,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,S
al_p UPT4H1,USP47,PCGF6,IGBP1,PLK1,HDGF,TBX18,DR1,BCLAF1,GIGY
roce F2,ZNF540,FGFR1,HSF4,CAPRIN1,CELF1,PAF1,RNF8,MDM2,PPM1F,
ss
YY1,PFDN5,CREB1,SRP9,PTPRK,ZEB1,RPS6KA5,NIPBL,RB1,PRMT5,
632
5
4
E
0
3
1.34
726
324
9
1.
3
5
E
0
3
1.33
559
301
9
1.
3
7
E
0
3
1.35
148
664
5
1.
3
7
E
-
3
G
O:
00
19
19
8
G
O:
00
05
00
1
G
O:
00
32
26
9
G
O:
00
48
64
ZFPM2,RNF168,CHMP1A,ZNF263,NR1H3,GRB10,FLCN,VPS72,RUNX2
,FBXW7,NCOR1,MEF2A,SETD8,TRIM28,UBP1,ZNF148,STAG2,TCF4,A
CD,SEMA4D,SMAD4,CREBZF,ING4,GLI3,ENG,SIRT7,GAPDH,WWP1,P
HF12,MDFI,CIRBP,HINFP,MLX,GLIS3,SMARCA4,PER3,GSK3A,NCOR2
,PHF21A,PDCD4,STAT6,ZBTB16,BAZ2A,RRP8,LMCD1,TSG101,CC2D1
A,GATA2
transmembrane receptor protein
phosphatase activity
mol
ecul
ar_f
unct
ion
0
3
PTPN6,PTPRK,PTPRF,PTPRS,PTPRC,PTPRD
4.50
225
428
3
transmembrane receptor protein tyrosine
phosphatase activity
mol
ecul
ar_f
unct
ion
PTPN6,PTPRK,PTPRF,PTPRS,PTPRC,PTPRD
4.50
225
428
3
negative regulation of cellular protein
metabolic process
biol
ogic
al_p
roce
ss
EIF2B4,PSMB10,IGF1R,TNRC6A,NOC2L,UBXN1,FMR1,SMAD7,USP4,
HDAC6,PSMB9,DNAJC10,PTPN6,IGBP1,ANAPC4,PLK1,CLN8,GIGYF2,
WAC,ZNF540,CAPRIN1,CELF1,RNF8,PPM1F,SRP9,NF1,RB1,RNF168,
SH3BP5,RGS3,NR1H3,PTEN,PRKRIP1,PTPRC,PSMC6,PSMC4,SEMA4
D,ENG,GAPDH,PHF1,CIRBP,RGS2,PDCD4,CRIPAK,PSMA1,CDK5RAP
1,SPRED1,DUSP6,PDPK1,UBR5,WNK1
1.53
714
598
9
anatomical structure formation involved in
morphogenesis
biol
ogic
al_p
roce
ss
FZD6,CADM1,IGF1R,LAMB1,NPHP3,RAF1,COL9A1,BDNF,CPE,PLCD1
,COL2A1,TBX2,CNTF,SMAD7,GLG1,ARHGEF12,RNH1,CD72,TTLL3,LE
F1,PAX8,ITGA9,ADAMTS1,BCL2L11,ADAM8,CD9,SIPA1L1,KRIT1,MIN
K1,PDLIM5,ACTR3,LHX4,VASP,CSNK2A1,PRKACA,SDCCAG8,ZC3H1
2A,SLC11A2,AAMP,CNP,TBX18,BBS1,STK4,FGFR1,CAPRIN1,PAF1,KI
1.25
668
407
3
1.
3
9
E
0
3
1.
3
9
E
0
3
1.
3
9
E
0
3
1.
3
9
E
-
6
G
O:
00
50
85
1
G
O:
00
30
17
6
G
O:
00
05
79
3
AA0586,FKBP1A,SSH2,THBS3,CREB1,NF1,ZEB1,CRIP1,RGMB,COL18
A1,NPR1,RPS6KA5,NIPBL,PKD2,SLC12A6,MAPK8IP3,ZFPM2,PAFAH1
B1,IL18,ADAM15,USP33,NRP1,PTEN,FYN,ALDH1A3,RUNX2,FBXW7,S
MARCD3,IFT172,PXN,SRGAP2,MEF2A,TCTN1,CACNB1,MYCBP2,MYL
K,RAB8A,TRIM28,COL9A3,PTPRC,UBP1,FLOT1,RANBP9,WDR35,PAK
1,EVC,NCK2,RAB10,SEMA6A,CTSH,SEMA4D,CSF1R,C3,ROBO3,SMA
D4,DDAH1,LMBR1,EZR,FLNA,GLI3,TMED2,ENG,EXT1,ERCC1,GAA,ST
K36,TBCE,ASAP1,UNC5B,PTPRD,ITGA5,PDGFRB,COL8A1,DZIP1,CC2
D2A,FARP1,RUNX1,SMARCA4,KIF13B,PTPN23,TLN1,GSK3A,ANKRD6
,SETD2,COL13A1,PTGIS,TROVE2,MYO1E,TANC1,ROBO2,CACNB3,P
MP22,CLIC4,NTRK1,SMAD9,DUSP6,TGFBR3,TMEM237,SEPT2,PKD1,
FOXC1,STK24,SSH1,C2CD3,EYA2,CLASP1,TENM4,GATA2
0
3
antigen receptor-mediated signaling
pathway
biol
ogic BTN3A1,HLA-DPB1,PTPN22,HLAal_p DQA1,PTPN6,VASP,RC3H1,TAB2,PRKCH,LCP2,PTEN,FYN,PHPT1,IKB
roce KB,MEF2A,CSK,PTPRC,PAK1,CACNB3,PDPK1
ss
2.07
271
269
1
integral to endoplasmic reticulum
membrane
cell
ular HLA-DPB1,GPAA1,DERL2,HLA-C,HLA_co DQA1,MARCH6,PIGS,RHBDD1,EMC3,PKD2,HLAmpo F,TMEM66,EMC4,ELOVL1,EXT1,CANX,AMFR
nent
2.22
323
899
2
endoplasmic reticulum-Golgi intermediate
compartment
cell
ular
LMAN2,CLN8,MCFD2,SERPINH1,RGMB,DDHD2,P4HB,TMED3,TMED2,
_co
TRAPPC12,YIF1A,NUCB1
mpo
nent
2.66
539
576
6
1.
4
3
E
0
3
1.
4
9
E
0
3
1.
4
9
E
0
3
G
O:
00
33
26
1
G
O:
00
16
46
2
G
O:
00
70
72
7
regulation of S phase
pyrophosphatase activity
cellular macromolecule localization
biol
ogic
al_p BCL6,PAF1,INO80,RB1,CHMP1A,CUL4A,PTPRC,SMARCA4
roce
ss
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,ERCC6L2,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,DYNC1I1,
ARHGEF25,RGL4,STARD13,STARD9,ABCC1,DDX23,DNAJC10,RAB35
,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX
9,TBC1D2B,DNM1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,T
BC1D14,TNK2,GIT2,MTG1,RAB18,PMS1,PLEKHG4,FAM13A,INO80,RA
mol
LGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,NTPCR,GN
ecul
AI1,PAFAH1B1,DNALI1,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP
ar_f
1,SRGAP2,ATP11B,SSBP1,DDX41,RNF213,ABCA2,DENND4C,MAP4K
unct
4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,KIFC2,ARHGAP29,SGSM3,GO
ion
PC,PPA2,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,KLC1,NAV1,DNH
D1,RAB5A,BCS1L,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASA
P1,NUBP1,RGS2,RAD51B,MYO7B,FARP1,RAP1B,SMARCA4,DHX40,R
AD54L2,KIF13B,DOCK8,LONRF3,MYO1E,DYNC1I2,RGL2,CHD2,LONP
2,ACIN1,PSD3,BNIP2,NTRK1,SHPRH,DHX37,RAPGEF6,SMARCAD1,D
ENND6B
RAB3GAP2,RALGAPA2,GAS8,CPE,MARCH5,BCL6,GPAA1,NUP98,SM
biol AD7,USP4,HDAC6,HGS,DERL2,SYTL4,RBPMS,AP3S2,UHMK1,KPNA6,
ogic PRKACA,PLK1,NUTF2,HERC2,VAMP7,BBS1,VTI1A,HPS4,TIMM23,MD
al_p M2,TLN2,SRP9,DDX58,RPL27,PTPRK,SNX13,AP4B1,NF1,RPL9,NIPBL,
roce RAB31,PKD2,LMNA,RB1,STX16,SYTL2,SYNE1,BICD1,GCC2,FLCN,RP
ss
L24,RPL37A,STX2,SNX17,KPNB1,PPP1R10,CACNB1,CLTCL1,DENND
4C,CSK,STX18,CLTB,FLOT1,GOPC,PAK1,LEPROT,RAB10,VPS45,AC
3.47
680
838
5
1.
5
2
E
0
3
1.28
635
836
7
1.
5
3
E
0
3
1.34
178
656
9
1.
5
4
E
0
3
D,TIMM50,OS9,SMAD4,GRPEL2,C1QTNF3,EZR,RPL4,FLNA,SUN2,GLI
3,TMED2,VTI1B,SLC25A6,VAMP4,MDFI,STAM2,RPLP0,KIF13B,TLN1,N
LGN2,PDIA3,LONP2,CSNK1E,ATG3,SPCS3,PKD1,PDPK1,KPNA1,CD6
3,UBR5,CLASP1
G
O:
00
09
18
9
G
O:
00
45
90
0
G
O:
00
06
39
7
G
O:
00
06
50
8
deoxyribonucleoside diphosphate
biosynthetic process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
10.1
044
743
7
negative regulation of translational
elongation
biol
ogic
al_p RNF8,SRP9,RNF168
roce
ss
10.1
044
743
7
mRNA processing
biol
ogic
al_p
roce
ss
SFSWAP,CDK13,SART1,SUPT5H,RBM17,CLNS1A,SNRNP70,DDX23,N
OL3,PRPF40A,DDX39A,SUGP1,DHX9,SYMPK,EFTUD2,PRPF3,PAIP1,
CELF1,SF3A2,PAF1,EIF4B,HNRNPA3,PRMT5,PAN2,SRPK1,CSTF1,RQ
CD1,PARN,DDX41,SRRM2,SKIV2L2,PRPF8,HNRNPL,HNRNPH3,SRSF
10,FIP1L1,THOC2,NCBP2,TGS1,CDK11A,CLASRP,SNRPE,PRPF4B,S
ON,LUC7L3,PABPC1,PABPN1
1.55
963
972
2
proteolysis
biol
ogic
al_p
roce
ss
USP10,CRBN,PSMB10,SIRT2,DDI2,SPOP,CPE,UBXN1,DPP4,NLN,SM
AD7,USP4,HDAC6,CASP4,DERL2,PSMB9,ADAMTS1,CPM,RAD23A,SC
RN3,USP47,ADAM8,DNAJC10,PRKACA,ANAPC4,PLK1,PREPL,HERC2
,ATG4B,CLN8,DNPEP,USP20,WAC,C2,CFB,MMP16,RNF8,MDM2,RHB
DD1,RHBDF1,SERPINH1,NUB1,CAPN10,CASP2,USP24,LTBP4,USP3,
RNF168,SENP2,RNF217,TPP1,ADAM15,USP33,NR1H3,PAN2,USP7,C
UL4A,CHFR,FAP,PTEN,C1R,FBXW7,LGMN,HERPUD1,ADAMTS18,US
1.34
042
435
1.
5
4
E
0
3
1.
5
4
E
0
3
1.
5
6
E
0
3
1.
5
9
E
0
3
G
O:
00
07
01
0
G
O:
00
51
28
7
G
O:
00
48
81
2
G
O:
00
42
cytoskeleton organization
P15,PSMC6,RNF146,AGBL5,PSMC4,CTSH,OS9,TGFB1I1,USP54,C1S,
PCSK7,WWP1,UBA6,MAN1B1,USP40,RHBDF2,LONRF3,FBXW2,ATG4
A,ATXN3,DPP7,AMFR,LONP2,PSMA1,CSNK1E,STAMBPL1,SPCS3,SE
NP6,TSG101,ACAN,C2CD3,MMP25,UBR5
RAF1,BCL6,HDAC6,TTLL3,ARPC4TTLL3,STARD9,NISCH,PAM,CEP135,MARK4,CAPZB,PRPF40A,RANB
P1,SIPA1L1,MINK1,RHOF,ACTR3,VASP,PLK1,CNP,CLN8,PPM1F,TLN2
biol
,INO80,SSH2,LIMCH1,NF1,NUMA1,CAPN10,PKD2,LMNA,RB1,NEXN,P
ogic
AFAH1B1,ARPC2,SYNE1,BICD1,NTMT1,GCC2,CYTH2,PLK2,DAAM1,P
al_p
TEN,PHPT1,PXN,SRGAP2,NCOR1,MEF2A,WASH4P,VILL,MYCBP2,CD
roce
K5RAP2,TBCD,RANBP9,PAK1,NCK2,SEMA6A,TRPM7,CSF1R,ACTR2,
ss
SS18,NAV1,EZR,FHOD1,FLNA,SUN2,NOX4,GAPDH,TBCE,HAUS5,PD
GFRB,SDAD1,TLN1,TWF1,ATXN3,CORO7,CRIPAK,SON,CLIC4,BNIP2,
BRWD1,SENP6,PDPK1,SSH1,CLASP1
NAD binding
mol
ecul
ar_f
unct
ion
neuron projection morphogenesis
biol
ogic
al_p
roce
ss
phosphoric ester hydrolase activity
mol
ecul
ar_f
unct
SIRT2,IDH3G,ALDH1A3,IDH1,NDUFV1,NDUFS2,SIRT7,GAPDH,IDH3B,
SIRT3
FZD6,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,ARHGEF12,CD72,I
TGA9,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,CSNK2A1,SLC11A
2,CNP,FGFR1,CAPRIN1,SSH2,CREB1,RGMB,RPS6KA5,MAPK8IP3,PA
FAH1B1,USP33,NRP1,PTEN,FYN,SRGAP2,MEF2A,TCTN1,CACNB1,M
YCBP2,RAB8A,COL9A3,PTPRC,FLOT1,RANBP9,PAK1,NCK2,RAB10,S
EMA6A,SEMA4D,ROBO3,EZR,GLI3,EXT1,TBCE,UNC5B,PTPRD,ITGA5
,FARP1,KIF13B,TLN1,ROBO2,CACNB3,NTRK1,STK24,SSH1,CLASP1
MYO1D,EPHX2,PLCD1,PTPN22,PLD1,SMPD4,PNKP,PTPN6,CSNK2A1
,IGBP1,PRKACA,PDE7B,PPP5C,CNP,PLCB4,FGFR1,ADCY4,PDE4D,F
KBP1A,MTMR11,PPM1F,SSH2,CREB1,ZCCHC9,PTPRK,NTPCR,NEDD
8-
1.37
311
002
6
2.93
625
279
3
1.45
338
33
1.46
812
639
7
1.
6
2
E
0
3
1.
6
6
E
0
3
1.
6
9
E
0
3
1.
6
9
E
57
8
G
O:
00
31
51
9
G
O:
00
44
43
0
G
O:
00
30
96
8
ion
MDP1,MDP1,GPCPD1,SYTL2,PDE8A,BICD1,PLD6,TENC1,MTMR14,PT
EN,PHPT1,PTP4A2,PTPRF,PPP1R10,MEF2A,PTPRS,PTPRC,MTMR9,
SEMA4D,TIMM50,CDC14B,PTPRD,PDGFRB,PTPN4,FARP1,PTPN23,P
PAP2A,PDIA3,NTRK1,SPRED1,DUSP6,SSH1,EYA2,WNK1
0
3
3.14
849
874
9
1.
7
1
E
0
3
PcG protein complex
cell
ular
_co EED,PCGF6,CSNK2A1,PCGF1,YY1,PHF1,PHC3,PHF19,PHC2
mpo
nent
cytoskeletal part
MYO1D,SIRT2,SEPT5,GAS8,MMS19,HDAC6,DYNC1I1,LANCL2,SYTL4,
TTLL3,ARPC4TTLL3,BCL2L11,STARD9,CEP135,MARK4,ADAM8,MAP7D1,CAPZB,RA
NBP1,SIPA1L1,MINK1,PDLIM5,ACTR3,PRKACA,DHX9,PLK1,SDCCAG
8,TTC19,DNM1L,HERC2,SEPT4,CNP,PLCB4,FLG,CCDC14,PDE4D,SH
cell ARPIN,DPF2,TCHP,KIAA0586,ZFYVE26,DIS3L,INO80,FLII,NUMA1,TPM
ular 4,MED28,PKD2,LMNA,PPP2R3C,RB1,GNAI1,PAFAH1B1,DNALI1,CHM
_co P1A,ARPC2,BICD1,PLK2,NRP1,DAAM1,FYN,IQGAP1,CEP112,PXN,SR
mpo GAP2,NCOR1,SMEK1,TCTN1,CLTCL1,MYLK,ABCA2,RAB8A,CSK,CDK
nent 5RAP2,TBCD,DDHD2,FLOT1,KIFC2,GOPC,RANBP9,WDR35,PAK1,EV
C,ACTR2,SS18,SMAD4,FNTB,KLC1,NAV1,EZR,DNHD1,FHOD1,ACTR1
0,AK5,PHF1,TBCE,NUP85,HAUS5,CLIP2,DZIP1,CC2D2A,MYO7B,LMN
B1,LRPPRC,YIF1A,KIF13B,PTPN23,TLN1,TTLL11,NARF,MYO1E,DYNC
1I2,PSMA1,TANC1,PSD3,CLIC4,BNIP2,SEPT2,C2CD3,CLASP1,CC2D1
A
1.29
448
980
2
1.
7
3
E
0
3
endoplasmic reticulum unfolded protein
response
biol
ogic
ACADVL,VAPB,DERL2,XBP1,ASNS,HDGF,SEC31A,LMNA,TPP1,HERP
al_p
UD1,PDIA5,YIF1A,TLN1,GSK3A,AMFR
roce
ss
2.32
286
767
1
1.
7
3
E
0
3
G
O:
00
32
40
3
G
O:
00
09
98
7
protein complex binding
mol
ecul
ar_f
unct
ion
IGF1R,LAMB1,UTRN,SMAD7,HDAC6,NISCH,CD9,PLK1,COL16A1,WAC
,PMS1,PAF1,SHARPIN,FKBP1A,TLN2,NIPBL,STRN4,LTBP4,GNAI1,PA
FAH1B1,ARPC2,GRB10,FLCN,PTEN,FYN,IQGAP1,PXN,ITGB5,CDK5R
AP2,AAK1,CTSH,ENG,ITGA5,TLN1,NCOR2,IGF2,CDK5RAP1,TGFBR3,
UQCRH,PDPK1
cellular process
FZD6,MARVELD1,CDK14,USP10,RNASEH2B,SLC25A37,CRBN,OBFC1
,RAB3GAP2,PBX2,LPP,DHX34,KANK2,CRIP2,ACADVL,EIF2B4,GTF3C
2,CADM1,RAI1,PSMB10,XRN1,CKB,CLMN,IGF1R,AVL9,LAMB1,GK5,N
PHP3,PTS,TNRC6A,MYO1D,SLC22A23,SIRT2,EPHX2,UTRN,RALGAP
A2,MYNN,TRNAU1AP,BTN3A1,NOC2L,PPIL2,TARS,RAF1,NLRP1,ZNF
131,SEPT5,GP1BB,F11R,LEPRE1,SLC16A3,PPP1R13B,GAS8,COL9A1
,RSC1A1,SFSWAP,CDK13,RBM6,BDNF,TAZ,SIN3B,ATP2B1,SPOP,CP
E,CBX5,PLCD1,SART1,COL2A1,RAB34,SUPT5H,SUPT20H,RILPL1,HL
Abiol DPB1,ST3GAL1,MARCH5,UBXN1,DPP4,PWP1,FBXO32,BCL6,FUBP1,Z
ogic NF783,CMPK2,TBX2,ENOSF1,PTPN22,MMS19,GBP3,SPATA20,SHMT
al_p 2,ZFP91,CNTF,EEF2K,PLD1,VAPB,GPAA1,CUX1,PGS1,RBM17,CLNS1
roce A,NUP98,EED,SLC9B2,AMT,FMR1,SMPD4,SMAD7,MCF2L,USP4,BMP
ss
8A,PPFIBP2,HDAC6,GLG1,ARHGEF12,EHMT1,ATP6V1D,VRK2,DYNC
1I1,RNH1,ZNF496,HGS,TYW1B,CASP4,DERL2,IL15RA,NARS,LANCL2,
H6PD,CD72,SYTL4,DGKA,TTLL3,ARPC4TTLL3,PRMT10,PNKP,LEF1,GLS,PAX8,HLAC,SUPT4H1,ZNF83,PSMB9,EMX2,ITGA9,ARHGEF25,ADAMTS1,RGL4,
BCL2L13,BCL2L11,RBPMS,XYLT1,STARD13,ZSCAN31,STARD9,XBP1,
COG4,FDPS,NISCH,PAM,ABCC1,NOM1,CEP135,SNRNP70,HSD17B12
,DDX23,HLADQA1,RAD23A,AP3S2,METTL3,APITD1,MPDU1,MARK4,UHMK1,USP4
7,ADAM8,NOL3,POLR3E,CAPZB,GABPB1,PRPF40A,DNAJC10,RNF22
1.61
757
638
9
1.
7
3
E
0
3
1.02
597
584
9
1.
7
6
E
0
3
0,RAB35,XAF1,CD9,PCGF6,RANBP1,SIPA1L1,MARCH6,DDX39A,KRIT
1,KPNA6,SKIV2L,MINK1,PDLIM5,RHOF,PTPN6,SUGP1,EEF1A1,ACTR
3,LHX4,VASP,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC
4,RPP14,DHX9,PIGS,PLK1,APLNR,SDCCAG8,ZNF446,PNPO,PDE7B,A
SNS,TBC1D2B,COL16A1,NUTF2,JAG2,TTC19,DNM1L,TXNL1,PTGES2,
UPF1,ZNF621,HDGF,FDXR,RC3H1,PPP5C,PIGG,PDXK,NPC1,SHISA5,
CCNL1,RHOBTB1,HERC2,CHD6,ZC3H12A,NUP210,TBC1D10B,SEPT4
,MIB2,POLM,SLC11A2,SYMPK,EFTUD2,AAMP,FAM58A,RAB24,ATG4B
,SLC26A6,IL13RA1,LSAMP,CNP,CLN8,TBX18,PIGN,GCDH,LBX2,PCGF
1,VAMP7,DR1,BCLAF1,CAMK2D,FYTTD1,ZNF721,ZNF397,JHDM1D,SL
C16A1,ZNF710,PLCB4,BBS1,JAM2,GIGYF2,DNPEP,TBC1D14,GALK2,
PRPF3,TNK2,COL14A1,USP20,GIT2,FLG,DCAF11,WAC,STK4,ZNF142,
FUBP3,TRO,MTG1,RARS,ZNF540,SLC38A2,ALDH18A1,TPCN2,COPS7
B,VTI1A,FGFR1,HPS4,RAB18,HSF4,DISP1,PAIP1,CAPRIN1,GTF3C1,M
MP16,ERH,NADSYN1,PMS1,ADCY4,CELF1,SNCAIP,PDE4D,SLC4A2,R
NASET2,SF3A2,GSDMD,TIMM23,PAF1,TAB2,SGK1,PLEKHG4,SLC9A5
,SHARPIN,DPF2,TCHP,CPT1B,CHKB,NADK,IDI1,RNF8,KIAA0586,CYP
2R1,SEC31A,MDM2,RHBDD1,SNAP23,COL12A1,FKBP1A,ZCCHC14,Z
FYVE26,PRKCH,MTMR11,DAZAP1,ANAPC16,PPM1F,ZNF595,TBP,DIS
3L,IDH3G,YY1,FAM13A,TLN2,INO80,GPAT2,GMEB2,SSH2,THBS3,MC
FD2,PFDN5,TTC1,CREB1,NPTN,SRP9,RALGPS2,NAGK,FLII,TNFRSF2
5,PLEKHG5,QSOX1,RPRD1A,CCNDBP1,DDX58,ALDH6A1,RPL27,ZCC
HC9,LCP2,CCNL2,PTPRK,SNX13,DFNA5,AP4B1,RHBDF1,SERPINH1,
LIMCH1,MAGI1,SNX21,NF1,ZEB1,ACAA1,NEK3,EIF4B,CRIP1,NUB1,IFI
TM3,LGALS3BP,ASCC2,ATG12,SPSB3,NUMA1,TPM4,RGMB,COL18A1
,RTKN,EBF1,RPL9,MED28,PHF15,FKBP10,UNKL,NPR1,ZNF3,RPS6KA
5,G3BP1,NIPBL,RAB31,ALKBH3,ADSL,ALG6,ST3GAL4,BRD9,CAPN10,
DCAF8,GCNT2,NTPCR,ZNF837,PKD2,CASP2,SLC12A6,HNRNPA3,RX
RB,GALT,UBE2Q1,NEDD8MDP1,MDP1,UBAC1,LMNA,RSL1D1,MITF,NOL8,ITGA3,USP24,RB1,PR
MT5,HMGXB3,LTBP4,MAPK8IP3,RABGGTA,GNAI1,USP3,PLEKHA2,ST
X16,MZF1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,RNF168,MARK3
,PAFAH1B1,ZNF865,MFSD10,SENP2,ISYNA1,EDEM2,GPCPD1,IL18,P
UM2,MTCH1,RNF217,ESAM,SLFN11,CALCOCO2,STARD3,TPP1,SYTL
2,DNALI1,SUB1,PWP2,CHMP1A,PDE8A,NSA2,AACS,ARPC2,SYNE1,S
TK38L,EPN2,DDX6,ACAP2,ZNF558,ANXA5,GALNT2,ADAM15,SH3BP5,
MUM1,USP33,ZNF263
G
O:
00
07
50
7
G
O:
00
16
57
0
G
O:
00
16
74
0
heart development
biol
ogic
al_p
roce
ss
NPHP3,RAF1,TAZ,SIN3B,CPE,COL2A1,TBX2,SMAD7,ADAMTS1,PAM,
TBX18,STK4,FGFR1,TAB2,FKBP1A,NF1,CRIP1,NIPBL,PKD2,RXRB,LM
NA,ZFPM2,SENP2,ADAM15,NRP1,PTEN,SMARCD3,MEF2A,OXCT1,GL
I3,TMED2,ENG,NOX4,GAA,PDGFRB,EPOR,SMARCA4,GSK3A,NCOR2,
SETD2,DUSP6,TGFBR3,PKD1,FOXC1,C2CD3,TENM4
1.55
713
842
9
histone modification
biol
ogic
al_p
roce
ss
SIRT2,NOC2L,EED,HDAC6,EHMT1,LEF1,PCGF1,DR1,JHDM1D,WAC,H
SF4,PAF1,RNF8,PHF15,RPS6KA5,NIPBL,PRMT5,USP3,RNF168,FLCN,
NCOR1,SETD8,MAPK8,WDR61,ING4,MSL1,SIRT7,PHF1,SMARCA4,SE
TD2,KANSL3,ATXN3,BAZ2A,PHF19,UBR5,EYA2,SMARCAD1,GATA2
1.63
565
506
3
mol
ecul
ar_f
unct
ion
CDK14,ACADVL,CKB,IGF1R,GK5,SIRT2,RAF1,CDK13,TAZ,ST3GAL1,C
MPK2,SHMT2,ZFP91,EEF2K,VAPB,PGS1,PARP6,EED,AMT,EHMT1,VR
K2,DGKA,PRMT10,PNKP,XYLT1,XBP1,FDPS,GLT8D1,METTL3,MARK4
,UHMK1,ADAM8,POLR3E,MINK1,PTPN6,CSNK2A1,NOD1,PRKACA,PL
K1,ASNS,HDGF,PIGG,PDXK,CCNL1,POLM,FAM58A,CLN8,PIGN,CAMK
2D,GALK2,TNK2,STK4,ALDH18A1,FGFR1,ADCY4,TAB2,SGK1,CPT1B,
CHKB,NADK,SEC31A,FKBP1A,PRKCH,PPM1F,GPAT2,NAGK,CCNL2,N
F1,ACAA1,NEK3,NPR1,RPS6KA5,ALG6,ST3GAL4,GCNT2,NTPCR,PKD
2,GALT,LMNA,RB1,PRMT5,HMGXB3,LTBP4,MAPK8IP3,RABGGTA,MA
RK3,TPP1,STK38L,GALNT2,SH3BP5,NTMT1,RGS3,PLK2,NRP1,UST,M
AST2,PTEN,FYN,SRPK1,IQGAP1,FBXW7,PHPT1,HERPUD1,IKBKB,PX
N,OXCT1,PRKRIP1,SETD8,STK19,MAPK8,MYLK,N6AMT1,TRIM28,MA
P4K4,CSK,PTPRC,CDK6,AAK1,ST6GALNAC5,PHKG2,PAK1,NCK2,AC
transferase activity
1.20
241
709
1.
8
0
E
0
3
1.
8
4
E
0
3
1.
9
2
E
0
3
G
O:
00
31
39
9
G
O:
00
09
16
6
regulation of protein modification process
nucleotide catabolic process
D,TRPM7,WDR4,CSF1R,DGKZ,ELOVL1,FUT4,FNTB,CHURC1FNTB,DTYMK,MBOAT2,CLK3,DLST,HGSNAT,MGAT5,MAPK12,AK5,B4
GALT4,ENG,NOX4,EXT1,GAPDH,NRBP2,B3GAT3,STK36,PDIA5,NAT9,
MDFI,RABGGTB,NAA10,RGS2,LPCAT1,PDGFRB,TGS1,CDK11A,CAR
D14,MKNK2,NAA16,YIF1A,CRCP,CLK4,TLN1,ADRBK2,GSK3A,SIK3,TH
UMPD2,POLG,POLR2J3,SETD2,TWF1,PCYT1A,KANSL3,PIGO,PRPF4
B,IGF2,FTSJ3,WDFY3,PSTK,GPHN,PDCD4,CRIPAK,CSNK1E,CDK5RA
P1,NTRK1,SPRED1,TNFRSF10B,PHKG1,DUSP6,TGFBR3,ZDHHC8,SI
RT3,UCK1,RRP8,PKD1,PDPK1,STK24,HEMK1,CDK5RAP3,GAK,ALG9,
RBKS,PANK3,FASTK,WNK1
ACADVL,PSMB10,IGF1R,NOC2L,RAF1,UBXN1,ZFP91,CNTF,EEF2K,V
APB,SMAD7,USP4,PSMB9,RBPMS,XBP1,APITD1,ADAM8,DNAJC10,P
TPN6,IGBP1,NOD1,PRKACA,ANAPC4,PLK1,ASNS,HDGF,CCNL1,SEP
T4,SYMPK,FAM58A,TNK2,STK4,FGFR1,ADCY4,TAB2,SEC31A,FKBP1
biol
A,PPM1F,NPTN,CCNL2,NF1,RPS6KA5,NIPBL,PKD2,LMNA,RB1,MAPK
ogic
8IP3,SENP2,TPP1,SH3BP5,RGS3,FLCN,NRP1,PTEN,IQGAP1,FBXW7,
al_p
HERPUD1,PXN,NCOR1,FECH,PRKRIP1,MAPK8,CSK,PTPRC,PSMC6,
roce
WDR61,PSMC4,PAK1,NCK2,SEMA4D,CSF1R,C3,SMAD4,CDC14B,AK5
ss
,ENG,ARNT,NOX4,PHF1,PDIA5,MDFI,ITGA5,RGS2,PDGFRB,CARD14,
TNFRSF14,YIF1A,TLN1,GSK3A,TWF1,IGF2,PDCD4,CRIPAK,PSMA1,C
DK5RAP1,NTRK1,SPRED1,TNFRSF10B,DUSP6,PHF19,PKD1,PDPK1,
CDK5RAP3,UBR5,WNK1,GATA2
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
biol
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DNM1L,
ogic
UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,CNP,TBC1D14,TNK2,
al_p
GIT2,MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RALGPS2
roce
,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GALT,GNAI1,PAF
ss
AH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP
2,ATP11B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,T
BCD,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB
1.31
500
832
8
1.
9
5
E
0
3
1.29
761
535
7
2.
0
0
E
0
3
3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,ATP8B2,AR
HGEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOC
K8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,N
TRK1,DHX37,RAPGEF6,DENND6B
G
O:
00
46
77
7
G
O:
00
45
45
4
G
O:
00
30
52
9
G
O:
00
09
89
0
protein autophosphorylation
biol
ogic IGF1R,EEF2K,VRK2,UHMK1,MINK1,CSNK2A1,PRKACA,CAMK2D,STK
al_p 4,FGFR1,FYN,TRIM28,CSK,PTPRC,AAK1,PAK1,TRPM7,CSF1R,CLK3,
roce ENG,PDGFRB,CLK4,NTRK1,PDPK1,STK24
ss
1.85
063
633
2
cell redox homeostasis
biol
ogic
DNAJC10,KRIT1,TXNL1,PTGES2,QSOX1,TXNDC5,TXNDC15,SEPW1,
al_p
P4HB,PDIA5,PDIA3
roce
ss
2.69
452
649
9
ribonucleoprotein complex
cell
ular
_co
mpo
nent
negative regulation of biosynthetic process
XRN1,TNRC6A,SART1,RBM17,FMR1,SNRNP70,DDX23,UHMK1,SUGP
1,DHX9,UPF1,RC3H1,EFTUD2,PRPF3,WAC,CAPRIN1,GTF3C1,CELF1,
SF3A2,SRP9,RPL27,PIH1D1,RPL9,RPS6KA5,G3BP1,HNRNPA3,RSL1D
1,PUM2,NSA2,DDX6,MRPS7,PAN2,RPL24,RPL37A,IQGAP1,RQCD1,D
DX41,SRRM2,SKIV2L2,PRPF8,HNRNPL,RHEB,HNRNPH3,PIWIL4,RPL
4,MRPL49,GAPDH,TBCE,CIRBP,TGS1,CANX,RPLP0,DNAJC21,SNRPE
,MRPL3,PRPF4B,TROVE2,PSMA1,CSNK1E,PABPC1,PABPN1
KANK2,ACADVL,EIF2B4,TNRC6A,SIRT2,NOC2L,SIN3B,CBX5,SUPT5H
biol ,BCL6,TBX2,CUX1,EED,FMR1,SMAD7,HDAC6,EHMT1,ZNF496,LANCL
ogic 2,LEF1,SUPT4H1,USP47,PCGF6,IGBP1,PLK1,HDGF,ZC3H12A,TBX18,
al_p DR1,BCLAF1,GIGYF2,ZNF540,FGFR1,HSF4,CAPRIN1,CELF1,PAF1,R
roce NF8,MDM2,PPM1F,YY1,PFDN5,CREB1,SRP9,PTPRK,ZEB1,IFITM3,RP
ss
S6KA5,NIPBL,RB1,PRMT5,ZFPM2,RNF168,CHMP1A,ZNF263,NR1H3,G
RB10,FLCN,VPS72,RUNX2,FBXW7,NCOR1,MEF2A,SETD8,TRIM28,UB
1.45
168
876
6
1.31
783
584
7
2.
0
5
E
0
3
2.
0
7
E
0
3
2.
0
8
E
0
3
2.
1
0
E
0
3
G
O:
00
19
43
9
G
O:
00
42
39
3
G
O:
00
80
aromatic compound catabolic process
P1,ZNF148,STAG2,TCF4,ACD,SEMA4D,SMAD4,C1QTNF3,CREBZF,IN
G4,CD276,GLI3,ENG,SIRT7,GAPDH,WWP1,PHF12,MDFI,CIRBP,HINFP
,LPCAT1,MLX,GLIS3,SMARCA4,PER3,GSK3A,NCOR2,PTGIS,PHF21A,
PDCD4,STAT6,ZBTB16,BAZ2A,RRP8,LMCD1,TSG101,CC2D1A,GATA2
RNASEH2B,CRBN,RAB3GAP2,DHX34,EIF2B4,XRN1,MYO1D,EPHX2,R
ALGAPA2,SEPT5,ATP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP
6V1D,RNH1,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC
10,RAB35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF
1A1,UPF3A,DHX9,PDE7B,TBC1D2B,DNM1L,UPF1,RC3H1,HERC2,CH
D6,TBC1D10B,SEPT4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB1
biol 8,PAIP1,PMS1,PDE4D,RNASET2,PLEKHG4,DIS3L,FAM13A,INO80,RAL
ogic GPS2,PLEKHG5,DDX58,RPL27,SNX13,NF1,EIF4B,RTKN,RPL9,G3BP1,
al_p RAB31,GALT,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,P
roce AN2,RPL24,ARHGAP9,RPL37A,IQGAP1,RQCD1,KPNB1,SRGAP2,ATP
ss
11B,PARN,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,T
BCD,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB
3,GRPEL2,TBC1D22A,RPL4,RAB5A,ATP5A1,TMED2,RASGRF2,ERCC
1,ATP8B2,ARHGEF7,ASAP1,RGS2,NCBP2,RAD51B,FARP1,RAP1B,SM
ARCA4,RPLP0,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,L
ONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,KPNA1,RAPGEF6,PABPC1,
SMARCAD1,DENND6B
1.25
804
051
8
histone binding
mol
ecul
ar_f
unct
ion
NOC2L,CBX5,LEF1,JHDM1D,RNF8,BRD9,USP3,TP53BP1,RNF168,ING
4,PHF1,HINFP,NCAPD3,SMARCA4,BAZ2A,RRP8,PHF19
2.14
593
428
4
regulation of primary metabolic process
biol
ogic
al_p
roce
FZD6,OBFC1,RAB3GAP2,PBX2,KANK2,ACADVL,EIF2B4,RAI1,PSMB10
,IGF1R,TNRC6A,SIRT2,EPHX2,RALGAPA2,MYNN,TRNAU1AP,NOC2L,
RAF1,ZNF131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,SUPT2
0H,UBXN1,BCL6,FUBP1,ZNF783,TBX2,MMS19,ZFP91,CNTF,EEF2K,V
1.12
202
676
5
2.
1
4
E
0
3
2.
1
6
E
0
3
2.
1
7
E
09
0
ss
APB,CUX1,EED,FMR1,SMAD7,MCF2L,USP4,HDAC6,GLG1,ARHGEF12
,EHMT1,ZNF496,HGS,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,E
MX2,RBPMS,STARD13,ZSCAN31,XBP1,PAM,SNRNP70,RAD23A,APIT
D1,UHMK1,USP47,ADAM8,GABPB1,DNAJC10,PCGF6,RANBP1,SIPA1
L1,PTPN6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STA
T2,ANAPC4,PLK1,ZNF446,ASNS,TBC1D2B,PTGES2,UPF1,ZNF621,HD
GF,CCNL1,CHD6,ZC3H12A,TBC1D10B,SEPT4,SYMPK,FAM58A,CLN8,
TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,
GIGYF2,TBC1D14,TNK2,GIT2,WAC,STK4,ZNF142,FUBP3,ZNF540,FGF
R1,HSF4,C2,CFB,PAIP1,CAPRIN1,ADCY4,CELF1,PAF1,TAB2,SGK1,D
PF2,CPT1B,RNF8,SEC31A,MDM2,RHBDD1,FKBP1A,PRKCH,PPM1F,Z
NF595,TBP,YY1,FAM13A,INO80,GMEB2,PFDN5,CREB1,NPTN,SRP9,F
LII,RPRD1A,DDX58,CCNL2,PTPRK,SNX13,RHBDF1,SERPINH1,NF1,Z
EB1,EIF4B,NUB1,IFITM3,ASCC2,RGMB,EBF1,MED28,NPR1,ZNF3,RPS
6KA5,NIPBL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,LTB
P4,MAPK8IP3,MZF1,ZFPM2,TP53BP1,RNF168,PAFAH1B1,ZNF865,SE
NP2,PUM2,TPP1,SUB1,CHMP1A,PDE8A,ACAP2,ZNF558,SH3BP5,ZNF
263,ZNF180,BICD1,ZNF276,RGS3,NR1H3,GRB10,USP7,FLCN,NRP1,C
UL4A,ZNF605,ZNF410,ARHGAP9,SAP30BP,MAST2,VPS72,PTEN,FYN,
SRPK1,RUNX2,IQGAP1,FBXW7,SMARCD3,HERPUD1,IKBKB,RQCD1,
PXN,SRGAP2,RFX7,NCOR1,MEF2A,FECH,PRKRIP1,SETD8,SMEK1,N
ECAB3,PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX3,ZNF565,ABCA2,A
FF4,TRIM28,DMTF1,CSK,CDK5RAP2,PTPRC,OAZ1,PSMC6,TBCD,UB
P1,WDR61,EBF4,ZNF148,ZNF76,PSMC4,ARHGAP29,SGSM3,STAG2,S
P110,PHKG2,PAK1,NCK2,TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,
CSF1R,ERC1,C3,NFYC,PIWIL4,SRSF10,SS18,RCOR3,SMAD4,CHURC
1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,C1QTNF3,TGFB1I1,INO80E,ZNF44,C
REBZF,ING4,CD276,ZNF687,CDC14B,CLK3,NR2C2,FHOD1,DNTTIP2,
FLNA,IRF9,GLI3,TMED2,MAPK12,CCDC59,DCAF6,AK5,ENG,SIRT7,ZS
CAN5A,TCF12,ARNT,NOX4,ZNF692,GAPDH,ERCC1,PHF1,STK36,WW
P1,ARHGEF7,PHF12,PDIA5,ASAP1,MED6,MDFI,CIRBP,ZNF554,CIZ1,I
0
3
TGA5,RGS2,HINFP,NCBP2,LPCAT1,MLX,PDGFRB,TGS1,CDK11A,GLI
S3,ELP6,CARD14,BDP1,TNFRSF14,RUNX1,MKNK2,SMARCA4,NAA16,
LRPPRC,YIF1A,RAD54L2,ZNF518B,CLK4,ZNF90,ZNF638,PER3,TLN1,
GSK3A,ZNF383,NCOR2,SETD2,TWF1,PPAP2A,IGF2,PTGIS,ATXN3,PS
TK,PHF21A,PDCD4,SOX13,CHD2,CRIPAK,LONP2,PSMA1,STAT6,CSN
K1E,SON,ZNF138,ZNF705A,CDK5RAP1,BNIP2,NTRK1,TFAM,SPRED1,
TNFRSF10B,BRWD1,SMAD9,LMF1,DUSP6,TGFBR3,ZBTB16,BAZ2A,R
RP8,VARS,LARS,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,
KPNA1,SSH1,CDK5RAP3,RAPGEF6,C2CD3,PABPC1,UBR5,FASTK,EY
A2,SMARCAD1,WNK1,CC2D1A,GATA2
G
O:
00
30
03
2
G
O:
00
16
31
1
G
O:
00
07
01
7
lamellipodium assembly
biol
ogic
al_p CAPZB,ACTR3,SSH2,PXN,SRGAP2,NCK2,ARHGEF7,NUP85,SSH1
roce
ss
dephosphorylation
biol
ogic
al_p
roce
ss
MYO1D,EPHX2,PTPN22,PNKP,PTPN6,CSNK2A1,IGBP1,PPP5C,SYMP
K,FKBP1A,MTMR11,PPM1F,SSH2,RPRD1A,ZCCHC9,PTPRK,NTPCR,N
EDD8MDP1,MDP1,SYTL2,TENC1,MTMR14,PTEN,IQGAP1,PHPT1,PTP4A2,P
TPRF,PPP1R10,MEF2A,SMEK1,PTPRS,PTPRC,MTMR9,SEMA4D,TIM
M50,CDC14B,THNSL2,PTPRD,PDGFRB,PTPN4,FARP1,PTPN23,PPAP
2A,SPRED1,DUSP6,SSH1,EYA2,WNK1
1.52
520
367
9
microtubule-based process
biol
ogic
al_p
roce
ss
NPHP3,HDAC6,DYNC1I1,TTLL3,STARD9,CEP135,AP3S2,MARK4,RAN
BP1,IGBP1,PLK1,CNP,INO80,NUMA1,PKD2,LMNA,RB1,BLOC1S5,PAF
AH1B1,BICD1,NTMT1,GCC2,PLK2,SRGAP2,NCOR1,CDK5RAP2,TBCD
,KIFC2,RANBP9,SS18,MEMO1,KLC1,NAV1,DNHD1,FLNA,SUN2,ACTR
10,GAPDH,STK36,TBCE,HAUS5,LRPPRC,KIF13B,TTLL11,ATXN3,DYN
C1I2,SON,BNIP2,SENP6,CLASP1
1.51
038
480
9
3.03
134
231
1
2.
2
2
E
0
3
2.
2
2
E
0
3
2.
2
3
E
0
3
G
O:
00
09
19
9
G
O:
00
10
55
8
G
O:
00
32
06
9
ribonucleoside triphosphate metabolic
process
negative regulation of macromolecule
biosynthetic process
regulation of nuclease activity
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
biol
AB18,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,DD
ogic
X58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2
al_p
,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX
roce
41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,P
ss
SMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC
1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,AS
AP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,UCK1,DHX37
,RAPGEF6,DENND6B
KANK2,EIF2B4,TNRC6A,SIRT2,NOC2L,SIN3B,CBX5,SUPT5H,BCL6,TB
X2,CUX1,EED,FMR1,SMAD7,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,S
UPT4H1,USP47,PCGF6,IGBP1,PLK1,HDGF,TBX18,DR1,BCLAF1,GIGY
biol F2,ZNF540,FGFR1,HSF4,CAPRIN1,CELF1,PAF1,RNF8,MDM2,PPM1F,
ogic YY1,PFDN5,CREB1,SRP9,PTPRK,ZEB1,IFITM3,RPS6KA5,NIPBL,RB1,
al_p PRMT5,ZFPM2,RNF168,CHMP1A,ZNF263,NR1H3,GRB10,FLCN,VPS72
roce ,RUNX2,FBXW7,NCOR1,MEF2A,SETD8,TRIM28,UBP1,ZNF148,STAG2
ss
,TCF4,ACD,SEMA4D,SMAD4,CREBZF,ING4,CD276,GLI3,ENG,SIRT7,G
APDH,WWP1,PHF12,MDFI,CIRBP,HINFP,MLX,GLIS3,SMARCA4,PER3,
GSK3A,NCOR2,PHF21A,PDCD4,STAT6,ZBTB16,BAZ2A,RRP8,LMCD1,
TSG101,CC2D1A,GATA2
biol
ogic
ACADVL,VAPB,XBP1,ASNS,HDGF,SEC31A,LMNA,TPP1,HERPUD1,PD
al_p
IA5,YIF1A,TLN1,GSK3A
roce
ss
1.29
500
852
2.
2
4
E
0
3
1.32
562
046
6
2.
2
4
E
0
3
2.43
255
864
5
2.
2
5
E
0
3
G
O:
00
16
07
1
G
O:
00
09
15
4
G
O:
00
71
31
0
mRNA metabolic process
purine ribonucleotide catabolic process
cellular response to organic substance
PSMB10,XRN1,SFSWAP,CDK13,SART1,SUPT5H,RBM17,CLNS1A,RN
H1,PSMB9,SNRNP70,DDX23,METTL3,NOL3,PRPF40A,DDX39A,SUGP
biol
1,UPF3A,DHX9,UPF1,RC3H1,SYMPK,EFTUD2,PRPF3,PAIP1,CELF1,S
ogic
F3A2,PAF1,RPL27,EIF4B,RPL9,HNRNPA3,PRMT5,DDX6,PAN2,RPL24,
al_p
RPL37A,SRPK1,CSTF1,RQCD1,PARN,DDX41,SRRM2,PSMC6,SKIV2L
roce
2,PRPF8,PSMC4,HNRNPL,HNRNPH3,SRSF10,RPL4,FIP1L1,THOC2,N
ss
CBP2,TGS1,CDK11A,RPLP0,CLASRP,SNRPE,PRPF4B,PSMA1,SON,L
UC7L3,PABPC1,PABPN1
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DNM1L,
UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,
biol
MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RALGPS2,PLE
ogic
KHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,PD
al_p
E8A,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,
roce
DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2
ss
L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,
TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASA
P1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,
MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,DENND6B
ACADVL,IGF1R,RAF1,F11R,COL2A1,HLADPB1,CMPK2,CNTF,EEF2K,VAPB,NUP98,SMPD4,SMAD7,HDAC6,GLG
1,ATP6V1D,VRK2,DERL2,IL15RA,LANCL2,LEF1,PAX8,HLAbiol
C,XBP1,HLAogic
DQA1,XAF1,PTPN6,PRKACA,STAT2,ASNS,COL16A1,HDGF,NPC1,ZC3
al_p
H12A,NUP210,IL13RA1,CAMK2D,FGFR1,ADCY4,PDE4D,PAF1,SHARP
roce
IN,SEC31A,MDM2,RHBDD1,FKBP1A,CREB1,NPTN,TNFRSF25,PTPRK,
ss
ZEB1,EIF4B,IFITM3,RPS6KA5,RAB31,CAPN10,RXRB,LMNA,LTBP4,PA
FAH1B1,IL18,TPP1,AACS,NR1H3,GRB10,FLCN,NRP1,PTEN,FYN,RUN
X2,PHPT1,HERPUD1,RQCD1,PXN,KPNB1,NCOR1,MEF2A,OXCT1,LIF
1.42
625
588
3
2.
2
7
E
0
3
1.29
633
577
3
2.
3
6
E
0
3
1.26
335
392
2
2.
3
7
E
0
3
G
O:
00
05
73
9
G
O:
00
09
26
1
mitochondrion
ribonucleotide catabolic process
R,FIBP,USP15,DDX41,HLAF,DENND4C,CSK,PTPRC,NUP37,IL10RA,PAK1,LEPROT,LEPR,RAB10,
RHEB,CTSH,GNB3,CSF1R,ATP6V0A1,SMAD4,TGFB1I1,DTYMK,NR2C
2,IRF9,ENG,ARNT,NOX4,GAPDH,PDIA5,NUP85,ITGA5,PDGFRB,EPOR
,TNFRSF14,YIF1A,TLN1,FGF14,GSK3A,NCOR2,IGF2,PTGIS,ATXN3,A
MFR,STAT6,ROBO2,NTRK1,SMAD9,DUSP6,TGFBR3,PDPK1,USF1,KP
NA1,SSH1,FMOD,ZC3H15,PGRMC2
SLC25A37,KANK2,ACADVL,CKB,PTS,RAI14,RAF1,TSTD1,TAZ,MARCH
5,CMPK2,ENOSF1,SHMT2,NLN,PGS1,SLC9B2,AMT,VRK2,NARS,H6P
D,GLS,BCL2L13,BCL2L11,GLOD4,STARD13,FDPS,GLT8D1,DDX23,MP
DU1,NOL3,RAB35,XAF1,PRKACA,RPP14,TTC19,DNM1L,PTGES2,FDX
R,HERC2,SEPT4,RAB24,CNP,CLN8,GCDH,SLC16A1,MTG1,RARS,ALD
H18A1,TIMM23,PAF1,SGK1,TCHP,CPT1B,IDI1,RHBDD1,IDH3G,GPAT2
cell
,ALDH6A1,ALKBH3,ADSL,CASP2,NUDT6,DHRS1,LYRM2,MTCH1,TPP1
ular
,SH3BP5,GARS,MRPS7,PLD6,FYN,IDH1,SRGAP2,OXCT1,FECH,ERAL
_co
1,COX7A2L,FIBP,SSBP1,MAPK8,AFF4,COX14,PSMC4,PPA2,ATPAF2,
mpo
TIMM50,HSD17B4,RPUSD4,GRPEL2,DDAH1,DTYMK,GOLPH3,DLST,M
nent
RPL49,CA5B,BCS1L,ATP5A1,NDUFV1,MAPK12,NDUFS2,NOX4,ETFA,
MTRF1L,SLC25A6,PRELID1,SDHA,REXO2,IDH3B,RGS2,NIT1,DIABLO,
LETMD1,LRPPRC,ACYP2,POLG,MRPL3,FPGS,SFXN3,D2HGDH,ATXN
3,PSTK,CARS2,SLC25A24,CLIC4,OXNAD1,TFAM,SLC25A46,ZDHHC8,
SIRT3,VARS,LETM1,UQCRH,DDAH2,HEMK1,MTO1,FASTK,EYA2,BCL
2L2
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
biol TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
ogic KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DNM1L,
al_p UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,
roce MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RALGPS2,PLE
ss
KHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,PD
E8A,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,
DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2
1.25
885
217
3
2.
4
1
E
0
3
1.29
522
303
8
2.
4
3
E
0
3
G
O:
19
01
29
2
G
O:
00
09
14
1
nucleoside phosphate catabolic process
nucleoside triphosphate metabolic process
L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,
TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASA
P1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,
MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DNM1L,
UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,CNP,TBC1D14,TNK2,
biol
GIT2,MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RALGPS2
ogic
,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GALT,GNAI1,PAF
al_p
AH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP
roce
2,ATP11B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,T
ss
BCD,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB
3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,ATP8B2,AR
HGEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOC
K8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,N
TRK1,DHX37,RAPGEF6,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
biol ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
ogic AB18,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,DD
al_p X58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2
roce ,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX
ss
41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,P
SMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC
1D22A,DTYMK,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHG
EF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,
LONRF3,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,UCK
1.29
005
223
7
2.
4
4
E
0
3
1.29
005
223
7
2.
4
4
E
0
3
1,DHX37,RAPGEF6,DENND6B
G
O:
00
08
09
2
G
O:
00
04
55
9
G
O:
00
16
56
9
G
O:
00
09
20
5
CLMN,MYO1D,UTRN,VAPB,GPAA1,HDAC6,DYNC1I1,BCL2L11,STARD
9,MARK4,CAPZB,PDLIM5,ACTR3,VASP,PLK1,MIB2,AFAP1,TLN2,INO8
0,SSH2,TRAF3IP1,FLII,LIMCH1,MAGI1,TPM4,MED28,CAPN10,PKD2,M
APK8IP3,NEXN,PAFAH1B1,ARPC2,SYNE1,STK38L,BICD1,DAAM1,MA
ST2,FYN,PXN,TNS1,WASH4P,VILL,MYLK,CDK5RAP2,TBCD,AGBL5,N
CK2,RAB10,TRPM7,ACTR2,EZR,FHOD1,FLNA,SUN2,ADD3,VEZT,GAP
DH,PTPN4,MYO7B,FARP1,LRPPRC,TLN1,TWF1,MYO1E,CORO7,SSH
1,CLASP1
cytoskeletal protein binding
mol
ecul
ar_f
unct
ion
alpha-mannosidase activity
mol
ecul
ar_f
unct
ion
MAN2C1,EDEM2,MAN1A2,MAN2A2,MAN1B1
4.82
384
387
5
covalent chromatin modification
biol
ogic
al_p
roce
ss
SIRT2,NOC2L,EED,HDAC6,EHMT1,LEF1,PCGF1,DR1,JHDM1D,WAC,H
SF4,PAF1,RNF8,PHF15,RPS6KA5,NIPBL,PRMT5,USP3,RNF168,FLCN,
NCOR1,SETD8,MAPK8,WDR61,ING4,MSL1,SIRT7,PHF1,SMARCA4,SE
TD2,KANSL3,ATXN3,BAZ2A,PHF19,UBR5,EYA2,SMARCAD1,GATA2
1.60
489
039
1
purine ribonucleoside triphosphate
metabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
biol
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
ogic
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
al_p
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
roce
AB18,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,DD
ss
X58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2
,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX
1.41
178
332
4
1.29
017
582
4
2.
5
0
E
0
3
2.
5
1
E
0
3
2.
5
7
E
0
3
2.
6
4
E
0
3
G
O:
00
44
27
0
G
O:
00
46
70
0
cellular nitrogen compound catabolic
process
heterocycle catabolic process
41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,P
SMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC
1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,AS
AP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,DENND6B
RNASEH2B,CRBN,RAB3GAP2,DHX34,EIF2B4,XRN1,MYO1D,RALGAP
A2,SEPT5,ATP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,R
NH1,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB
35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,UP
F3A,DHX9,PDE7B,TBC1D2B,DNM1L,UPF1,RC3H1,HERC2,CHD6,TBC1
D10B,SEPT4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB18,PAIP1,
biol PMS1,PDE4D,RNASET2,PLEKHG4,DIS3L,FAM13A,INO80,RALGPS2,P
ogic LEKHG5,DDX58,RPL27,SNX13,NF1,EIF4B,RTKN,RPL9,G3BP1,RAB31,
al_p GALT,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,PAN2,RP
roce L24,ARHGAP9,RPL37A,IQGAP1,RQCD1,KPNB1,SRGAP2,ATP11B,PA
ss
RN,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SK
IV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPE
L2,TBC1D22A,RPL4,RAB5A,ATP5A1,TMED2,RASGRF2,ERCC1,ATP8B
2,ARHGEF7,ASAP1,RGS2,NCBP2,RAD51B,FARP1,RAP1B,SMARCA4,
RPLP0,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,KPNA1,RAPGEF6,PABPC1,SMARCA
D1,DENND6B
RNASEH2B,CRBN,RAB3GAP2,DHX34,EIF2B4,XRN1,MYO1D,RALGAP
A2,SEPT5,ATP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,R
biol NH1,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB
ogic 35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,UP
al_p F3A,DHX9,PDE7B,TBC1D2B,DNM1L,UPF1,RC3H1,HERC2,CHD6,TBC1
roce D10B,SEPT4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB18,PAIP1,
ss
PMS1,PDE4D,RNASET2,PLEKHG4,DIS3L,FAM13A,INO80,RALGPS2,P
LEKHG5,DDX58,RPL27,SNX13,NF1,EIF4B,RTKN,RPL9,G3BP1,RAB31,
GALT,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,PAN2,RP
1.25
160
487
7
2.
6
9
E
0
3
1.25
160
487
7
2.
6
9
E
0
3
G
O:
00
48
51
9
negative regulation of biological process
L24,ARHGAP9,RPL37A,IQGAP1,RQCD1,KPNB1,SRGAP2,ATP11B,PA
RN,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SK
IV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPE
L2,TBC1D22A,RPL4,RAB5A,ATP5A1,TMED2,RASGRF2,ERCC1,ATP8B
2,ARHGEF7,ASAP1,RGS2,NCBP2,RAD51B,FARP1,RAP1B,SMARCA4,
RPLP0,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,KPNA1,RAPGEF6,PABPC1,SMARCA
D1,DENND6B
FZD6,CRBN,KANK2,ACADVL,EIF2B4,RAI1,PSMB10,CLMN,IGF1R,LAM
B1,NPHP3,TNRC6A,SIRT2,NOC2L,RAF1,LEPRE1,PPP1R13B,GAS8,R
SC1A1,SFSWAP,BDNF,SIN3B,CBX5,SART1,COL2A1,SUPT5H,MARCH
5,UBXN1,DPP4,LUC7L,BCL6,TBX2,PTPN22,CNTF,CUX1,EED,FMR1,S
MAD7,USP4,HDAC6,GLG1,ARHGEF12,EHMT1,ZNF496,HGS,LANCL2,
SYTL4,LEF1,PAX8,SUPT4H1,PSMB9,ADAMTS1,MEPE,NISCH,UHMK1,
USP47,ADAM8,NOL3,CAPZB,DNAJC10,CD9,PCGF6,KRIT1,PTPN6,LH
X4,CSNK2A1,IGBP1,PRKACA,ANAPC4,PLK1,ASNS,HDGF,RC3H1,NP
C1,ZC3H12A,CLN8,TBX18,DR1,BCLAF1,CAMK2D,JAM2,GIGYF2,TBC1
D14,WAC,STK4,TRO,ZNF540,TPCN2,FGFR1,HSF4,CAPRIN1,CELF1,P
biol
AF1,SHARPIN,TCHP,RNF8,MDM2,RHBDD1,FKBP1A,PRKCH,PPM1F,Y
ogic
Y1,PFDN5,CREB1,SRP9,DDX58,PTPRK,SNX13,DFNA5,RHBDF1,NF1,
al_p
ZEB1,IFITM3,ATG12,COL18A1,MED28,NPR1,RPS6KA5,G3BP1,NIPBL,
roce
PKD2,CASP2,MITF,RB1,PRMT5,ZFPM2,TXNDC5,RNF168,PAFAH1B1,
ss
SLFN11,CHMP1A,ANXA5,SH3BP5,ZNF263,BICD1,RGS3,NR1H3,GRB1
0,PLK2,FLCN,NRP1,CUL4A,CHFR,TENC1,IGFBP6,FAP,VPS72,PTEN,F
YN,SRPK1,RUNX2,IQGAP1,FBXW7,PHPT1,LGMN,RQCD1,SRGAP2,N
COR1,MEF2A,PRKRIP1,SETD8,PIAS2,VILL,MAPK8,UPK3B,USP15,TRI
M28,CSK,CDK5RAP2,PTPRC,PSMC6,TBCD,UBP1,CDK6,WDR61,ZNF1
48,PSMC4,SGSM3,STAG2,GOPC,PAK1,NCK2,LEPROT,RHEB,CTSH,T
CF4,ACD,SEMA4D,DGKZ,PIWIL4,SRSF10,SMAD4,C1QTNF3,TGFB1I1,
CREBZF,ING4,CD276,CDC14B,LRPAP1,FLNA,ATP5A1,GLI3,MAPK12,
EPS15L1,EPN1,ENG,SIRT7,NOX4,GAPDH,ERCC1,PHF1,BICC1,NRBP
2,WWP1,ARHGEF7,PHF12,MED6,UNC5B,MDFI,CIRBP,ITGA5,RGS2,HI
1.15
777
181
9
2.
7
3
E
0
3
NFP,STAM2,NCBP2,LPCAT1,MLX,GLIS3,TNFRSF14,DBF4,RUNX1,SM
ARCA4,RHBDF2,PER3,CD164,ADRBK2,GSK3A,ANKRD6,NCOR2,TWF
1,PPAP2A,PTGIS,PHF21A,PDCD4,SNX14,CRIPAK,PSMA1,STAT6,ROB
O2,CSNK1E,SON,PMP22,CLIC4,CDK5RAP1,BNIP2,NTRK1,SPRED1,D
USP6,TGFBR3,ZBTB16,BAZ2A,RRP8,LMCD1,PKD1,PDPK1,TSG101,U
SF1,FOXC1,DDAH2,STK24,PABPC1,UBR5,WNK1,CLASP1,CC2D1A,PL
A2G16,GATA2,BCL2L2
G
O:
00
35
09
1
G
O:
00
46
43
4
G
O:
00
06
phosphatidylinositol binding
organophosphate catabolic process
RNA processing
mol
ecul
ar_f
unct
ion
PLEKHA3,PLD1,GPAA1,MCF2L,LANCL2,NISCH,RAB35,SGK1,ZCCHC1
4,ZFYVE26,SNX13,SNX21,PLEKHA2,SYTL2,PXDC1,SNX17,PHF12,SN
X27,TWF1,WDFY3,MYO1E,SNX14
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,SMPD4,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,
RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,D
DX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,D
NM1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,CNP,TBC1D14,
biol
TNK2,GIT2,MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RAL
ogic
GPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GALT,GNAI
al_p
1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,PTEN,IQG
roce
AP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITP
ss
A,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SE
MA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,A
TP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DH
X40,DOCK8,LONRF3,GSK3A,MYO1E,PGM2,RGL2,CHD2,LONP2,ACIN
1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
biol SFSWAP,CDK13,RBM6,SART1,SUPT5H,RBM17,CLNS1A,TYW1B,RBP
ogic MS,SNRNP70,DDX23,NOL3,PRPF40A,DDX39A,SUGP1,RPP14,DHX9,
al_p CCNL1,SYMPK,EFTUD2,PRPF3,PAIP1,CELF1,SF3A2,PAF1,CCNL2,EI
roce F4B,HNRNPA3,NOL8,PRMT5,NSA2,BICD1,PAN2,SRPK1,CSTF1,INTS4
1.89
266
740
6
2.
7
9
E
0
3
1.28
000
856
2
2.
7
9
E
0
3
1.39
791
224
4
2.
8
0
E
39
6
G
O:
00
80
00
8
G
O:
00
05
93
2
G
O:
00
05
76
8
G
O:
00
09
14
4
ss
,RQCD1,PARN,DDX41,SRRM2,SKIV2L2,PRPF8,HNRNPL,HNRNPH3,W
DR4,SRSF10,RBMS1,CLK3,FIP1L1,THOC2,NCBP2,TGS1,CDK11A,CLA
SRP,CLK4,ZNF638,SNRPE,PRPF4B,FTSJ3,SON,CDK5RAP1,ZFC3H1,
RRP8,LUC7L3,ARL6IP4,MTO1,PABPC1,FASTK,PABPN1
0
3
Cul4-RING ubiquitin ligase complex
cell
ular
_co CRBN,DCAF11,DCAF8,CUL4A,DCAF6,DCAF17
mpo
nent
3.99
809
364
9
microtubule basal body
cell
ular
GAS8,PKD2,TCTN1,RAB8A,WDR35,EVC,EZR,DZIP1,CC2D2A,PTPN23,
_co
TTLL11,C2CD3
mpo
nent
2.46
941
078
3
endosome
purine nucleoside triphosphate metabolic
process
USP10,AVL9,RAB34,HLA-DPB1,PLD1,HGS,DERL2,SYTL4,HLAC,NISCH,HLA-DQA1,RAB35,VPS52,NPC1,MIB2,SLC11A2,VAMP7,HLAcell
DMB,TNK2,TPCN2,TAB2,SNX13,IFITM3,RAB31,STARD3,CHMP1A,AR
ular
PC2,CCDC115,FYN,PTP4A2,LGMN,CTNS,SNX17,ATP11B,WASH4P,H
_co
LAmpo
F,ABCA2,RAB8A,APPL2,FLOT1,LEPROT,RAB10,VPS45,ATP6V0A1,GO
nent
LPH3,RAB5A,SUN2,MCOLN1,VAMP4,STAM2,SNX27,PTPN23,CD164,N
TRK1,TSG101,CD63,SCAMP1,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
biol
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
ogic
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
al_p
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
roce
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
ss
AB18,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,DD
2.
8
1
E
0
3
2.
9
2
E
0
3
1.44
415
126
5
2.
9
7
E
0
3
1.28
473
204
4
3.
0
3
E
0
X58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2
,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX
41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,P
SMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC
1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,AS
AP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,DENND6B
G
O:
00
06
98
4
G
O:
00
09
05
9
ER-nucleus signaling pathway
biol
ogic
ACADVL,VAPB,DERL2,XBP1,ASNS,HDGF,SEC31A,LMNA,TPP1,FBXW
al_p
7,HERPUD1,PDIA5,YIF1A,TLN1,GSK3A,AMFR
roce
ss
macromolecule biosynthetic process
FZD6,OBFC1,PBX2,KANK2,EIF2B4,GTF3C2,RAI1,IGF1R,TNRC6A,SIR
T2,MYNN,TRNAU1AP,NOC2L,TARS,ZNF131,RSC1A1,SFSWAP,CDK13
,SIN3B,CBX5,SUPT5H,SUPT20H,ST3GAL1,PWP1,BCL6,FUBP1,ZNF78
3,TBX2,MMS19,EEF2K,GPAA1,CUX1,NUP98,EED,FMR1,SMAD7,MCF2
L,HDAC6,EHMT1,ZNF496,NARS,LANCL2,PNKP,LEF1,PAX8,SUPT4H1,
ZNF83,EMX2,RBPMS,XYLT1,ZSCAN31,XBP1,PAM,APITD1,UHMK1,US
biol P47,ADAM8,POLR3E,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1
ogic ,UPF3A,NOD1,STAT2,PIGS,PLK1,ZNF446,PTGES2,UPF1,ZNF621,HDG
al_p F,PPP5C,PIGG,NPC1,CCNL1,CHD6,ZC3H12A,FAM58A,TBX18,PIGN,L
roce BX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,GIGYF2,
ss
WAC,ZNF142,FUBP3,RARS,ZNF540,FGFR1,HSF4,PAIP1,CAPRIN1,GT
F3C1,CELF1,PAF1,TAB2,SGK1,DPF2,RNF8,SEC31A,MDM2,PRKCH,P
PM1F,ZNF595,TBP,YY1,INO80,GMEB2,MCFD2,PFDN5,CREB1,SRP9,F
LII,RPRD1A,DDX58,RPL27,CCNL2,PTPRK,SERPINH1,ZEB1,EIF4B,IFIT
M3,ASCC2,RGMB,EBF1,RPL9,MED28,ZNF3,RPS6KA5,NIPBL,ALG6,ST
3GAL4,BRD9,GCNT2,ZNF837,PKD2,RXRB,LMNA,RSL1D1,MITF,NOL8,
RB1,PRMT5,MZF1,ZFPM2,TP53BP1,RNF168,ZNF865,SENP2,EDEM2,I
3
2.13
427
841
5
3.
0
4
E
0
3
1.12
498
749
4
3.
0
8
E
0
3
G
O:
19
01
13
6
carbohydrate derivative catabolic process
L18,PUM2,SUB1,CHMP1A,PDE8A,ZNF558,GALNT2,ZNF263,ZNF180,BI
CD1,ZNF276,NR1H3,GARS,GRB10,MRPS7,USP7,FLCN,ZNF605,ZNF4
10,RPL24,UST,RPL37A,SAP30BP,MAST2,VPS72,PTEN,RNASEK,RUN
X2,CSTF1,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,PPP1R10,
MEF2A,FECH,SETD8,NECAB3,PIAS2,SSBP1,MAPK8,MYCBP2,USP15,
DDX41,MAN1A2,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RA
P2,PTPRC,OAZ1,UBP1,WDR61,EBF4,FARSA,ZNF148,ZNF76,STAG2,S
P110,PPA2,ST6GALNAC5,PHKG2,NCK2,TCF4,ACD,IKZF5,HMGN2,SE
MA4D,SSBP2,ERC1,NFYC,FUT4,PIWIL4,SRSF10,SS18,RCOR3,SMAD
4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,RPL4,ZNF44,CREBZF,ING4,C
D276,RBMS1,EIF3M,ZNF687,NR2C2,FHOD1,DNTTIP2,MRPL49,FLNA,I
RF9,MGAT5,GLI3,MAPK12,CCDC59,DCAF6,B4GALT4,ENG,SIRT7,ZSC
AN5A,TCF12,ARNT,NOX4,ZNF692,EXT1,GAPDH,PHF1,MTRF1L,B3GA
T3,STK36,WWP1,PHF12,TBCE,MED6,MDFI,CIRBP,ZNF554,CIZ1,RGS2
,HINFP,NCBP2,MAN2A2,MLX,PDGFRB,TGS1,CDK11A,MAN1B1,GLIS3,
ELP6,BDP1,DBF4,CANX,RUNX1,MKNK2,SMARCA4,NAA16,LRPPRC,R
PLP0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3,CHTF8,GSK3A,
SNRPE,POLG,ZNF383,MRPL3,POLR2J3,NCOR2,FPGS,SETD2,PIGO,P
DIA3,IGF2,PTGIS,TROVE2,ATXN3,PSTK,PHF21A,PDCD4,SOX13,PGM
2,CHD2,STAT6,CARS2,ZNF138,ZNF705A,NTRK1,TFAM,PHKG1,BRWD
1,SMAD9,LMF1,TGFBR3,ZBTB16,BAZ2A,SIRT3,SPCS3,EIF3I,RRP8,VA
RS,LARS,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,ACAN,C
DK5RAP3,FMOD,ALG9,PABPC1,EYA2,SMARCAD1,CC2D1A,GATA2,P
ABPN1
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
biol RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
ogic TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
al_p KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DNM1L,
roce UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,
ss
MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RALGPS2,NAG
K,PLEKHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GALT,GNAI1,PA
1.27
021
728
3
3.
0
9
E
0
3
G
O:
00
34
64
5
cellular macromolecule biosynthetic process
FAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,HEXA,ARHGAP9,IQGAP1
,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,P
SMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA
4D,GNB3,GRPEL2,TBC1D22A,RAB5A,HGSNAT,ATP5A1,TMED2,RASG
RF2,GUSB,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,S
MARCA4,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,PGM2,RGL2,CHD2,
LONP2,ACIN1,PSD3,CTBS,BNIP2,NTRK1,DHX37,ACAN,RAPGEF6,FM
OD,DENND6B
FZD6,OBFC1,PBX2,KANK2,EIF2B4,GTF3C2,RAI1,IGF1R,TNRC6A,SIR
T2,MYNN,TRNAU1AP,NOC2L,TARS,ZNF131,RSC1A1,SFSWAP,CDK13
,SIN3B,CBX5,SUPT5H,ST3GAL1,PWP1,BCL6,FUBP1,ZNF783,TBX2,M
MS19,EEF2K,GPAA1,CUX1,NUP98,EED,FMR1,SMAD7,MCF2L,HDAC6,
EHMT1,ZNF496,NARS,LANCL2,PNKP,LEF1,PAX8,SUPT4H1,ZNF83,E
MX2,RBPMS,XYLT1,ZSCAN31,XBP1,PAM,APITD1,UHMK1,USP47,ADA
M8,POLR3E,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,
NOD1,STAT2,PIGS,PLK1,ZNF446,PTGES2,UPF1,ZNF621,HDGF,PPP5
C,PIGG,NPC1,CCNL1,CHD6,ZC3H12A,FAM58A,TBX18,PIGN,LBX2,PC
GF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,GIGYF2,WAC,ZN
biol
F142,FUBP3,RARS,ZNF540,FGFR1,HSF4,PAIP1,CAPRIN1,GTF3C1,CE
ogic
LF1,PAF1,TAB2,SGK1,DPF2,RNF8,SEC31A,MDM2,PRKCH,PPM1F,ZN
al_p
F595,TBP,YY1,INO80,GMEB2,MCFD2,PFDN5,CREB1,SRP9,FLII,RPRD
roce
1A,DDX58,RPL27,CCNL2,PTPRK,ZEB1,EIF4B,ASCC2,RGMB,EBF1,RP
ss
L9,MED28,ZNF3,RPS6KA5,NIPBL,ALG6,ST3GAL4,BRD9,GCNT2,ZNF8
37,PKD2,RXRB,LMNA,RSL1D1,MITF,NOL8,RB1,PRMT5,MZF1,ZFPM2,
TP53BP1,RNF168,ZNF865,SENP2,EDEM2,PUM2,SUB1,CHMP1A,PDE
8A,ZNF558,GALNT2,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GARS,GR
B10,MRPS7,USP7,FLCN,ZNF605,ZNF410,RPL24,UST,RPL37A,SAP30
BP,VPS72,PTEN,RNASEK,RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,R
QCD1,RFX7,NCOR1,PPP1R10,MEF2A,FECH,SETD8,NECAB3,PIAS2,S
SBP1,MAPK8,MYCBP2,USP15,DDX41,MAN1A2,PBX3,ZNF565,ABCA2,
AFF4,TRIM28,DMTF1,CDK5RAP2,UBP1,WDR61,EBF4,FARSA,ZNF148,
ZNF76,STAG2,SP110,PPA2,ST6GALNAC5,PHKG2,NCK2,TCF4,ACD,IK
1.12
766
527
5
3.
1
3
E
0
3
ZF5,HMGN2,SEMA4D,SSBP2,ERC1,NFYC,FUT4,PIWIL4,SRSF10,SS18
,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,RPL4,ZNF44,CREBZF,ING4,RB
MS1,EIF3M,ZNF687,NR2C2,FHOD1,DNTTIP2,MRPL49,FLNA,IRF9,MG
AT5,GLI3,MAPK12,CCDC59,DCAF6,B4GALT4,ENG,SIRT7,ZSCAN5A,T
CF12,ARNT,NOX4,ZNF692,EXT1,GAPDH,PHF1,MTRF1L,B3GAT3,STK
36,WWP1,PHF12,TBCE,MED6,MDFI,CIRBP,ZNF554,CIZ1,RGS2,HINFP
,NCBP2,MAN2A2,MLX,PDGFRB,TGS1,CDK11A,MAN1B1,GLIS3,ELP6,
BDP1,DBF4,CANX,RUNX1,MKNK2,SMARCA4,NAA16,LRPPRC,RPLP0,
ZNF518B,CRCP,ZNF90,ZNF638,PER3,CHTF8,GSK3A,SNRPE,POLG,Z
NF383,MRPL3,POLR2J3,NCOR2,SETD2,PIGO,PDIA3,IGF2,PTGIS,TRO
VE2,ATXN3,PSTK,PHF21A,PDCD4,SOX13,PGM2,CHD2,STAT6,CARS2
,ZNF138,ZNF705A,NTRK1,TFAM,PHKG1,BRWD1,SMAD9,LMF1,TGFB
R3,ZBTB16,BAZ2A,SIRT3,SPCS3,EIF3I,RRP8,VARS,LARS,PHF19,LMC
D1,PKD1,PDPK1,TSG101,USF1,FOXC1,ACAN,CDK5RAP3,ALG9,PABP
C1,EYA2,SMARCAD1,CC2D1A,GATA2,PABPN1
G
O:
00
00
79
0
nuclear chromatin
cell
ular CBX5,EED,CSNK2A1,TBP,YY1,INO80,CREB1,USP3,NR1H3,RUNX2,S
_co MARCD3,NCOR1,MEF2A,TRIM28,INO80E,SIRT7,PHF12,NCAPD3,SMA
mpo RCA4,STAT6,FOXC1
nent
1.90
818
106
G
O:
00
16
86
0
intramolecular oxidoreductase activity
mol
ecul
ar_f
unct
ion
EIF2B4,SPATA20,PTGES2,IDI1,QSOX1,P4HB,PDIA5,EBPL,PDIA3,PTG
IS
2.70
135
257
G
O:
ribonucleoside triphosphate catabolic
process
biol
ogic
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
1.28
930
3.
1
7
E
0
3
3.
2
0
E
0
3
3.
2
00
09
20
3
G
O:
00
09
20
7
G
O:
00
06
47
6
purine ribonucleoside triphosphate catabolic
process
protein deacetylation
al_p TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
roce KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ss
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,
SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP
5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FAR
P1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LO
NP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
biol ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
ogic AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
al_p X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
roce CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
ss
DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,
SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP
5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FAR
P1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LO
NP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
biol
ogic
SIRT2,HDAC6,NIPBL,NCOR1,MAPK8,SIRT7,ATXN3,SPRED1,BAZ2A,SI
al_p
RT3,SMARCAD1
roce
ss
372
4
0
E
0
3
1.28
930
372
4
3.
2
0
E
0
3
2.55
515
443
8
3.
2
1
E
0
3
G
O:
00
05
63
8
G
O:
00
46
90
7
G
O:
00
31
22
7
G
O:
00
09
14
8.39
599
666
4
3.
2
6
E
0
3
1.27
385
467
5
3.
2
8
E
0
3
lamin filament
cell
ular
_co LMNA,LMNB1,NARF
mpo
nent
intracellular transport
SLC25A37,RAB3GAP2,NOC2L,BCL6,CUX1,NUP98,HDAC6,DYNC1I1,H
GS,DERL2,SYTL4,RBPMS,COG4,AP3S2,UHMK1,RAB35,RANBP1,DDX
39A,KPNA6,UPF3A,PRKACA,NUTF2,UPF1,NPC1,HERC2,CNP,VAMP7,
CAMK2D,FYTTD1,BBS1,TPCN2,VTI1A,HPS4,TIMM23,CPT1B,SEC31A,
biol MDM2,SNAP23,FKBP1A,SRP9,DDX58,RPL27,SNX13,AP4B1,NF1,RPL9
ogic ,RAB31,CAPN10,PKD2,LMNA,STX16,BLOC1S5,TXNDC5,PAFAH1B1,S
al_p TARD3,SYTL2,BICD1,GCC2,RPL24,RPL37A,STX2,SNX17,KPNB1,PPP
roce 1R10,WASH4P,CACNB1,CLTCL1,ABCA2,RAB8A,CSK,PTPRC,STX18,C
ss
LTB,GOPC,RAB10,VPS45,ACD,ERC1,TIMM50,OS9,SRSF10,SMAD4,G
RPEL2,C1QTNF3,RPL4,FLNA,HGSNAT,ATP5A1,GLI3,TMED2,SDCBP2
,THOC2,SCFD1,VTI1B,SLC25A6,VAMP4,MDFI,STAM2,NCBP2,MLX,VP
S51,TGS1,LRPPRC,RPLP0,SDAD1,SNX27,KIF13B,PDIA3,LONP2,ATG
3,LMF1,SPCS3,PKD1,TSG101,KPNA1,SCAMP1,UBR5,PABPN1
intrinsic to endoplasmic reticulum
membrane
cell
ular HLA-DPB1,GPAA1,DERL2,HLA-C,HLA_co DQA1,MARCH6,PIGS,RHBDD1,EMC3,PKD2,HLAmpo F,TMEM66,EMC4,ELOVL1,EXT1,CANX,AMFR,ALG9
nent
2.01
503
919
9
purine nucleoside triphosphate catabolic
process
biol
ogic
al_p
roce
ss
1.28
704
377
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
3.
3
6
E
0
3
3.
3
8
E
-
6
G
O:
00
06
19
5
G
O:
00
00
13
9
purine nucleotide catabolic process
Golgi membrane
AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,
SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP
5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FAR
P1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LO
NP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DNM1L,
UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,
biol
MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RALGPS2,PLE
ogic
KHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,PD
al_p
E8A,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,
roce
DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2
ss
L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,
TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASA
P1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,
MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,DENND6B
HLA-DPB1,ST3GAL1,PLD1,CUX1,SMPD4,GLG1,IL15RA,HLAC,XYLT1,COG4,HLAcell DQA1,RNF24,ACTR3,LMAN2,PTGES2,VTI1A,QSOX1,RHBDF1,ST3GA
ular L4,GCNT2,GOLGA8B,GOLGA8A,MAPK8IP3,STX16,GALNT2,UST,CLST
_co N2,CLTCL1,MAN1A2,HLAmpo F,SLC35D2,STX18,CLTB,GOPC,ST6GALNAC5,LEPROT,VPS45,ERC1,
nent FUT4,TMED3,SLC35A4,GOLPH3,MGAT5,TMED2,B4GALT4,SCFD1,PC
SK7,EXT1,B3GAT3,VAMP4,MAN2A2,LPCAT1,YIF1A,CORO7,SLC9A8,
GORASP1
0
3
1.28
201
770
5
3.
3
8
E
0
3
1.44
580
508
4
3.
3
9
E
0
3
G
O:
00
15
03
6
G
O:
00
17
14
8
G
O:
00
05
69
4
G
O:
00
15
92
3
G
O:
00
disulfide oxidoreductase activity
mol
ecul
ar_f
unct
ion
DNAJC10,TXNL1,PTGES2,QSOX1,TXNDC5,P4HB,PDIA5,PDIA3
3.08
726
008
negative regulation of translation
biol
ogic
EIF2B4,TNRC6A,FMR1,GIGYF2,ZNF540,CAPRIN1,CELF1,RNF8,SRP9,
al_p
RNF168,GAPDH,CIRBP
roce
ss
2.41
300
880
5
chromosome
OBFC1,SIN3B,CBX5,BCL6,NUP98,EED,EHMT1,DYNC1I1,APITD1,CSN
K2A1,PLK1,UPF1,RNF8,TBP,YY1,INO80,CREB1,NUMA1,RB1,USP3,TP
cell
53BP1,RNF168,PAFAH1B1,CHMP1A,NR1H3,RUNX2,SMARCD3,NCOR
ular
1,PPP1R10,MEF2A,SETD8,TRIM28,DSN1,NSFL1C,WDR61,NUP37,ST
_co
AG2,ACD,HMGN2,INO80E,CENPT,FLNA,SUN2,ADD3,SIRT7,ERCC1,P
mpo
HF1,PHF12,NUP85,NCAPD3,SMARCA4,LRPPRC,NCOR2,SETD2,PRP
nent
F4B,MAU2,STAT6,NSMCE4A,SHPRH,BAZ2A,RRP8,SEPT2,FOXC1,SM
ARCAD1,CLASP1
1.40
148
891
4
mannosidase activity
mol
ecul
ar_f
unct
ion
MAN2C1,EDEM2,MAN1A2,MAN2A2,MAN1B1
4.50
225
428
3
dentate gyrus development
biol
ogic
al_p
LEF1,EMX2,PTEN,MEF2A,CDK6
4.49
087
749
3.
4
2
E
0
3
3.
5
0
E
0
3
3.
5
1
E
0
3
3.
5
3
E
0
3
3.
5
7
21
54
2
G
O:
20
00
60
2
G
O:
00
04
44
8
G
O:
00
06
10
2
G
O:
00
46
01
5
roce
ss
8
regulation of interphase of mitotic cell cycle
biol
ogic KANK2,PSMB10,BCL6,PSMB9,USP47,PTPN6,PAF1,MDM2,INO80,PKD
al_p 2,CASP2,RB1,SLFN11,CHMP1A,CUL4A,PTEN,PSMC6,PSMC4,DGKZ,S
roce MARCA4,PSMA1
ss
1.88
616
854
9
isocitrate dehydrogenase activity
mol
ecul
ar_f
unct
ion
IDH3G,IDH1,IDH3B
8.10
405
771
isocitrate metabolic process
biol
ogic
al_p IDH3G,IDH1,IDH3B
roce
ss
8.08
357
949
6
regulation of transcription by glucose
biol
ogic
al_p CHMP1A,RRP8,USF1
roce
ss
8.08
357
949
6
E
0
3
3.
5
9
E
0
3
3.
6
1
E
0
3
3.
6
4
E
0
3
3.
6
4
E
0
3
G
O:
00
70
53
5
G
O:
19
01
36
1
G
O:
00
72
52
3
histone H2A K63-linked ubiquitination
organic cyclic compound catabolic process
purine-containing compound catabolic
process
biol
ogic
al_p RNF8,RNF168,UBR5
roce
ss
RNASEH2B,CRBN,RAB3GAP2,DHX34,EIF2B4,XRN1,MYO1D,EPHX2,R
ALGAPA2,SEPT5,ATP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP
6V1D,RNH1,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC
10,RAB35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF
1A1,UPF3A,DHX9,PDE7B,TBC1D2B,DNM1L,UPF1,RC3H1,HERC2,CH
D6,TBC1D10B,SEPT4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB1
biol 8,PAIP1,PMS1,PDE4D,RNASET2,PLEKHG4,DIS3L,FAM13A,INO80,RAL
ogic GPS2,PLEKHG5,DDX58,RPL27,SNX13,NF1,EIF4B,RTKN,RPL9,G3BP1,
al_p RAB31,GALT,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,P
roce AN2,RPL24,ARHGAP9,RPL37A,IQGAP1,RQCD1,SNX17,KPNB1,SRGA
ss
P2,ATP11B,PARN,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,P
SMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA
4D,GNB3,GRPEL2,TBC1D22A,RPL4,RAB5A,ATP5A1,TMED2,RASGRF
2,ERCC1,ATP8B2,ARHGEF7,ASAP1,RGS2,NCBP2,RAD51B,FARP1,RA
P1B,SMARCA4,RPLP0,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,
CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,KPNA1,RAPGEF6,P
ABPC1,SMARCAD1,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
biol
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
ogic
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DNM1L,
al_p
UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,
roce
MTG1,RAB18,PMS1,PDE4D,PLEKHG4,FAM13A,INO80,RALGPS2,PLE
ss
KHG5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,PD
E8A,DDX6,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,
8.08
357
949
6
3.
6
4
E
0
3
1.23
906
335
1
3.
6
5
E
0
3
1.27
875
833
8
3.
6
7
E
0
3
DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2
L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,
TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASA
P1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,
MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,DENND6B
G
O:
00
35
60
1
G
O:
00
16
23
6
G
O:
00
09
14
3
protein deacylation
biol
ogic
SIRT2,HDAC6,NIPBL,NCOR1,MAPK8,SIRT7,ATXN3,SPRED1,BAZ2A,SI
al_p
RT3,SMARCAD1
roce
ss
2.51
184
673
6
macroautophagy
biol
ogic
al_p SUPT5H,HDAC6,NPC1,ATG4B,TBC1D14,WAC,ATG12,NRBP2,ATG3
roce
ss
2.81
985
331
3
nucleoside triphosphate catabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
biol
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
ogic
AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
al_p
X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
roce
CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
ss
DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,
SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP
5A1,TMED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FAR
P1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LO
1.28
254
754
7
3.
6
9
E
0
3
3.
7
4
E
0
3
3.
7
7
E
0
3
NP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
nucleoside-triphosphatase regulator activity
mol
ecul
ar_f
unct
ion
RAB3GAP2,EIF2B4,RALGAPA2,MCF2L,ARHGEF12,ARHGEF25,RGL4,
STARD13,DNAJC10,RANBP1,SIPA1L1,KRIT1,MINK1,TBC1D2B,HERC2
,TBC1D10B,TBC1D14,TNK2,GIT2,PLEKHG4,FAM13A,RALGPS2,PLEK
HG5,NF1,RTKN,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,DE
NND4C,MAP4K4,TBCD,ARHGAP29,SGSM3,GOPC,GRPEL2,TBC1D22
A,RASGRF2,ARHGEF7,ASAP1,RGS2,FARP1,DOCK8,RGL2,PSD3,BNI
P2,RAPGEF6,DENND6B
1.47
132
492
9
immune response-activating cell surface
receptor signaling pathway
biol
ogic BTN3A1,HLA-DPB1,PTPN22,HLAal_p DQA1,PTPN6,VASP,RC3H1,TAB2,PRKCH,LCP2,PTEN,FYN,PHPT1,IKB
roce KB,MEF2A,CSK,PTPRC,PAK1,CACNB3,PDPK1
ss
1.91
101
170
1
response to topologically incorrect protein
biol
ogic ACADVL,VAPB,HDAC6,DERL2,XBP1,ASNS,HDGF,SEC31A,RHBDD1,S
al_p ERPINH1,LMNA,EDEM2,TPP1,HERPUD1,PDIA5,YIF1A,TLN1,GSK3A,A
roce TXN3,AMFR
ss
1.91
101
170
1
G
O:
00
31
58
9
cell-substrate adhesion
biol
ogic
al_p
roce
ss
LAMB1,UTRN,BCL6,BCL2L11,HSD17B12,MINK1,PPM1F,THBS3,PTPR
K,NF1,ITGA3,PLEKHA2,ARPC2,ADAM15,PTEN,PXN,SRGAP2,TBCD,C
DK6,ABI3BP,TRPM7,PPFIA1,COL8A1,ITGA11,COL13A1,ATXN3,PKD1,
PDPK1
1.70
693
986
3
G
O:
helicase activity
mol
ecul
DHX34,ERCC6L2,DDX23,DDX39A,SKIV2L,DHX9,UPF1,CHD6,INO80,D
DX58,G3BP1,DDX6,SSBP1,DDX41,SKIV2L2,SMARCA4,DHX40,RAD54
1.84
564
G
O:
00
60
58
9
G
O:
00
02
42
9
G
O:
00
35
96
6
3.
7
8
E
0
3
3.
7
9
E
0
3
3.
7
9
E
0
3
3.
8
0
E
0
3
3.
8
00
04
38
6
G
O:
00
05
88
5
G
O:
00
32
88
0
G
O:
00
32
27
0
G
O:
00
33
ar_f
unct
ion
L2,CHD2,SHPRH,DHX37,SMARCAD1
461
3
Arp2/3 protein complex
cell
ular
_co ARPC4-TTLL3,ACTR3,ARPC2,ACTR2
mpo
nent
5.59
733
110
9
regulation of protein localization
biol
ogic
al_p
roce
ss
1.52
053
332
6
positive regulation of cellular protein
metabolic process
regulation of organelle organization
CADM1,RALGAPA2,NLRP1,SYTL4,RBPMS,PAM,UHMK1,ADAM8,PRKA
CA,DNM1L,VAMP7,DISP1,MDM2,DDX58,RHBDF1,NF1,PKD2,RSL1D1,
RB1,GCC2,NR1H3,FLCN,FBXW7,MAPK8,MYCBP2,RAB8A,CSK,AAK1,
GOPC,LEPROT,CSF1R,SMAD4,C1QTNF3,FLNA,GLI3,VAMP4,MDFI,R
HBDF2,SEPT2,PKD1,PDPK1,KPNA1,UBR5
ACADVL,PSMB10,IGF1R,RAF1,ZFP91,CNTF,VAPB,SMAD7,PSMB9,RB
PMS,XBP1,APITD1,UHMK1,ADAM8,UPF3A,NOD1,PRKACA,ANAPC4,P
biol LK1,ASNS,HDGF,SEPT4,SYMPK,TNK2,STK4,FGFR1,PAIP1,ADCY4,TA
ogic B2,SEC31A,MDM2,FKBP1A,NPTN,NUB1,RPS6KA5,NIPBL,PKD2,LMNA
al_p ,MAPK8IP3,SENP2,TPP1,NR1H3,FLCN,NRP1,PTEN,IQGAP1,FBXW7,H
roce ERPUD1,PXN,NCOR1,CSK,PTPRC,PSMC6,WDR61,PSMC4,PAK1,SEM
ss
A4D,CSF1R,C3,SMAD4,CDC14B,ENG,ARNT,NOX4,PHF1,PDIA5,MDFI,
CIRBP,ITGA5,PDGFRB,CARD14,TNFRSF14,YIF1A,TLN1,GSK3A,IGF2,
PSMA1,CSNK1E,NTRK1,TNFRSF10B,PHF19,PKD1,PDPK1,PABPC1
biol NOC2L,CDK13,MARCH5,HDAC6,ARPC4ogic TTLL3,BCL2L11,PAM,CAPZB,RANBP1,ACTR3,ANAPC4,PLK1,DNM1L,
al_p TBC1D14,PPM1F,SSH2,RPS6KA5,NIPBL,RB1,PRMT5,NEXN,ARPC2,P
roce LK2,FLCN,PTEN,PHPT1,NCOR1,MEF2A,WASH4P,VILL,MAPK8,MYCB
1
E
0
3
3.
8
4
E
0
3
3.
8
7
E
0
3
1.33
298
130
7
3.
9
0
E
0
3
1.43
434
870
7
3.
9
3
E
04
3
G
O:
00
09
96
6
G
O:
00
05
80
2
G
O:
ss
regulation of signal transduction
P2,CDK5RAP2,TBCD,WDR61,PAK1,NCK2,ACD,CSF1R,ACTR2,GOLPH
3,FHOD1,NOX4,ERCC1,PHF1,PDGFRB,TWF1,IGF2,CRIPAK,CLIC4,PH
F19,SENP6,SSH1,UBR5,CLASP1,GATA2
FZD6,CDK14,KANK2,IGF1R,NPHP3,RALGAPA2,RAF1,BCL6,PTPN22,Z
FP91,CNTF,SMAD7,MCF2L,HDAC6,GLG1,ARHGEF12,VRK2,HGS,LAN
CL2,LEF1,ARHGEF25,BCL2L11,RBPMS,STARD13,XBP1,ADAM8,SIPA
1L1,MINK1,RHOF,PTPN6,CSNK2A1,IGBP1,NOD1,STAT2,TBC1D2B,DN
M1L,RC3H1,PPP5C,SHISA5,RHOBTB1,TBC1D10B,SEPT4,MIB2,TBX18
,BCLAF1,TBC1D14,USP20,GIT2,STK4,FGFR1,DISP1,TAB2,PLEKHG4,
SHARPIN,MDM2,FKBP1A,PRKCH,FAM13A,PFDN5,NPTN,PLEKHG5,S
NX13,RHBDF1,NF1,ZEB1,G3BP1,PKD2,RB1,LTBP4,MAPK8IP3,PAFAH
biol
1B1,SENP2,MTCH1,ACAP2,USP33,BICD1,RGS3,NR1H3,CYTH2,GRB1
ogic
0,PLK2,FLCN,ARHGAP9,PTEN,FYN,RUNX2,IQGAP1,FBXW7,PHPT1,IK
al_p
BKB,RQCD1,PXN,SRGAP2,LTBR,NCOR1,SETD8,TCTN1,PIAS2,MAPK
roce
8,SH3BP2,USP15,MAP4K4,CSK,PTPRC,RNF146,FLOT1,ARHGAP29,S
ss
GSM3,AAK1,PAK1,EVC,NCK2,LEPROT,RHEB,SEMA4D,CSF1R,DGKZ,
C3,SMAD4,TBC1D22A,C1QTNF3,TGFB1I1,GOLPH3,LRPAP1,APOL3,F
LNA,GLI3,RASGRF2,EPS15L1,EPN1,ENG,ARNT,NOX4,BICC1,STK36,
ARHGEF7,ASAP1,UNC5B,MDFI,ITGA5,RGS2,STAM2,PDGFRB,CARD1
4,FARP1,RUNX1,SMARCA4,ADRBK2,GSK3A,ANKRD6,NLGN2,IGF2,P
TGIS,PDCD4,SNX14,RGL2,CRIPAK,PSD3,CSNK1E,BNIP2,NTRK1,SPR
ED1,TNFRSF10B,DUSP6,TGFBR3,TMEM237,LMCD1,PDPK1,RAPGEF
6,C2CD3,UBR5,CC2D1A,GATA2
0
3
1.20
765
047
7
trans-Golgi network
cell
ular HLA-DPB1,SMPD4,PAM,HLA_co DQA1,SLC11A2,AP4B1,RAB31,BICD1,GCC2,CYTH2,CLTCL1,CLTB,RA
mpo B10,GOLPH3,FLNA,VAMP4,PSD3,SCAMP1
nent
1.98
330
629
9
regulation of cell communication
biol
ogic
1.19
221
FZD6,CDK14,KANK2,IGF1R,NPHP3,RALGAPA2,RAF1,BDNF,SUPT5H,
BCL6,PTPN22,ZFP91,CNTF,SMAD7,MCF2L,HDAC6,GLG1,ARHGEF12,
3.
9
5
E
0
3
3.
9
9
E
0
3
4.
0
00
10
64
6
G
O:
00
00
15
1
G
O:
00
19
78
al_p VRK2,HGS,LANCL2,SYTL4,LEF1,PAX8,ARHGEF25,BCL2L11,RBPMS,
roce STARD13,XBP1,NISCH,ADAM8,SIPA1L1,MINK1,RHOF,PTPN6,CSNK2
ss
A1,IGBP1,NOD1,PRKACA,STAT2,TBC1D2B,DNM1L,RC3H1,PPP5C,NP
C1,SHISA5,RHOBTB1,TBC1D10B,SEPT4,MIB2,TBX18,BCLAF1,TBC1D
14,USP20,GIT2,WAC,STK4,FGFR1,DISP1,SNCAIP,TAB2,PLEKHG4,SH
ARPIN,MDM2,FKBP1A,PRKCH,FAM13A,PFDN5,CREB1,NPTN,PLEKH
G5,SNX13,RHBDF1,NF1,ZEB1,G3BP1,CAPN10,PKD2,RB1,LTBP4,MAP
K8IP3,PAFAH1B1,SENP2,MTCH1,AACS,ACAP2,USP33,BICD1,RGS3,N
R1H3,CYTH2,GRB10,PLK2,FLCN,ARHGAP9,PTEN,FYN,RUNX2,IQGAP
1,FBXW7,PHPT1,IKBKB,RQCD1,PXN,SRGAP2,LTBR,NCOR1,MEF2A,
OXCT1,SETD8,TCTN1,PIAS2,MAPK8,SH3BP2,USP15,RAB8A,MAP4K4
,CSK,PTPRC,RNF146,FLOT1,ARHGAP29,SGSM3,AAK1,PAK1,EVC,NC
K2,LEPROT,RHEB,SEMA4D,CSF1R,DGKZ,C3,SMAD4,TBC1D22A,C1Q
TNF3,TGFB1I1,GOLPH3,LRPAP1,APOL3,FLNA,GLI3,RASGRF2,EPS15
L1,EPN1,ENG,ARNT,NOX4,BICC1,NRBP2,SLC25A6,STK36,ARHGEF7,
ASAP1,UNC5B,MDFI,ITGA5,RGS2,STAM2,PDGFRB,CARD14,FARP1,R
AP1B,RUNX1,SMARCA4,ADRBK2,GSK3A,ANKRD6,NLGN2,IGF2,PTGI
S,PDCD4,SNX14,RGL2,CRIPAK,PSD3,CSNK1E,BNIP2,NTRK1,SPRED
1,TNFRSF10B,DUSP6,TGFBR3,TMEM237,SPCS3,LMCD1,PDPK1,RAP
GEF6,C2CD3,UBR5,CC2D1A,TENM4,GATA2
369
6
ubiquitin ligase complex
cell
ular CRBN,PPIL2,SPOP,USP47,ANAPC4,MIB2,DCAF11,SHARPIN,RNF8,AN
_co APC16,DCAF8,RNF168,USP33,CUL4A,FBXW7,OS9,DCAF6,WWP1,DC
mpo AF17,KLHL7,ATG3
nent
1.85
987
267
9
small conjugating protein-specific protease
activity
mol
ecul
ar_f
unct
ion
2.59
745
439
4
USP10,USP4,USP47,USP3,SENP2,USP33,USP7,USP15,ATXN3,SENP
6
7
E
0
3
4.
3
0
E
0
3
4.
3
1
E
-
3
G
O:
00
42
99
5
G
O:
00
15
92
4
G
O:
00
05
07
2
G
O:
00
00
0
3
cell projection
FZD6,CADM1,IGF1R,NPHP3,MYO1D,UTRN,RAF1,SEPT5,GAS8,RSC1
A1,RAB34,UBXN1,DPP4,FMR1,MCF2L,TTLL3,PAM,MARK4,UHMK1,CA
PZB,RAB35,SIPA1L1,MINK1,PDLIM5,ACTR3,VASP,PPP5C,SEPT4,SLC
11A2,CNP,VAMP7,CAMK2D,PLCB4,BBS1,TNK2,CAPRIN1,ADCY4,SHA
cell
RPIN,SNAP23,FKBP1A,TLN2,DDX58,PTPRK,MAGI1,NF1,NEK3,PKD2,
ular
STRN4,MAPK8IP3,PAFAH1B1,DNALI1,ARPC2,ADAM15,PLK2,NRP1,M
_co
TMR14,FAP,PTEN,FYN,IQGAP1,IFT172,PXN,SRGAP2,TCTN1,MYCBP
mpo
2,MYLK,RAB8A,SWAP70,CDK6,CLTB,AAK1,GOPC,WDR35,PAK1,EVC,
nent
RAB10,RHEB,SEMA6A,CTSH,TRPM7,GNB3,DGKZ,ACTR2,ROBO3,EZ
R,FHOD1,RAB5A,GLI3,ARHGEF7,CTTN,ITGA5,DZIP1,CC2D2A,FARP1,
CANX,KIF13B,PTPN23,TLN1,TTLL11,TWF1,TANC1,PSD3,ROBO2,CLIC
4,NTRK1,TMEM237,SEPT2,PKD1,KPNA1,SSH1,C2CD3,TENM4
mannosyl-oligosaccharide mannosidase
activity
mol
ecul
ar_f
unct
ion
EDEM2,MAN1A2,MAN2A2,MAN1B1
5.40
270
514
transforming growth factor beta receptor,
cytoplasmic mediator activity
mol
ecul
ar_f
unct
ion
SMAD7,SMAD4,ENG,SMAD9
5.40
270
514
microtubule cytoskeleton organization
biol
ogic
al_p
roce
HDAC6,TTLL3,STARD9,CEP135,MARK4,RANBP1,PLK1,CNP,INO80,N
UMA1,PKD2,LMNA,RB1,PAFAH1B1,BICD1,NTMT1,GCC2,PLK2,SRGA
P2,NCOR1,CDK5RAP2,TBCD,RANBP9,SS18,NAV1,FLNA,SUN2,GAPD
H,TBCE,HAUS5,ATXN3,SON,BNIP2,SENP6,CLASP1
1.58
768
396
4
1.27
315
411
1
4.
3
2
E
0
3
4.
3
7
E
0
3
4.
3
7
E
0
3
4.
4
1
E
22
6
G
O:
00
97
35
4
G
O:
00
18
34
2
G
O:
00
07
04
9
ss
prenylation
biol
ogic
al_p RABGGTA,FNTB,CHURC1-FNTB,RABGGTB
roce
ss
5.38
905
299
7
protein prenylation
biol
ogic
al_p RABGGTA,FNTB,CHURC1-FNTB,RABGGTB
roce
ss
5.38
905
299
7
cell cycle
MARVELD1,CDK14,KANK2,PSMB10,SIRT2,SEPT5,PPP1R13B,CDK13,
SART1,SUPT5H,BCL6,NUP98,LEF1,PSMB9,BCL2L11,STARD9,CEP13
5,APITD1,UHMK1,USP47,PRPF40A,RANBP1,PTPN6,ACTR3,CSNK2A1
,PRKACA,ANAPC4,PLK1,SDCCAG8,ASNS,JAG2,TTC19,UPF1,PPP5C,
CCNL1,SEPT4,FAM58A,CAMK2D,GIGYF2,WAC,FGFR1,ERH,PMS1,PA
biol F1,RNF8,MDM2,ZFYVE26,ANAPC16,INO80,CCNDBP1,CCNL2,PTPRK,
ogic NEK3,NUMA1,NIPBL,PKD2,CASP2,RB1,PRMT5,GNAI1,USP3,PAFAH1
al_p B1,SLFN11,CHMP1A,NTMT1,PLK2,PLD6,FLCN,CUL4A,CHFR,PTEN,FB
roce XW7,NCOR1,SETD8,CLTCL1,DMTF1,CDK5RAP2,PTPRC,PSMC6,DSN
ss
1,CDK6,NUP37,APPL2,PSMC4,SGSM3,STAG2,PARD6G,RHEB,DGKZ,
PIWIL4,DTYMK,CENPT,ING4,CDCA3,CDC14B,NR2C2,FLNA,SUN2,MA
PK12,SIRT7,NUP85,HAUS5,RGS2,HINFP,PDGFRB,NCAPD3,RAD51B,
CDK11A,DBF4,SMARCA4,CHTF8,IGF2,DYNC1I2,MAU2,PDCD4,PSMA
1,CSNK1E,SON,CDK5RAP1,BNIP2,RRP8,SEPT2,SENP6,PKD1,TSG10
1,FOXC1,CDK5RAP3,GAK,SMARCAD1,CLASP1,PLA2G16,GORASP1
1.24
362
761
5
0
3
4.
4
1
E
0
3
4.
4
1
E
0
3
4.
4
4
E
0
3
G
O:
00
48
58
3
G
O:
00
31
98
8
regulation of response to stimulus
membrane-bounded vesicle
FZD6,CDK14,KANK2,CADM1,IGF1R,NPHP3,RALGAPA2,BTN3A1,RAF1
,NLRP1,SUPT5H,HLADPB1,BCL6,PTPN22,ZFP91,CNTF,SMAD7,MCF2L,HDAC6,GLG1,ARH
GEF12,VRK2,HGS,LANCL2,LEF1,HLAC,ARHGEF25,BCL2L11,RBPMS,STARD13,XBP1,HLADQA1,ADAM8,SIPA1L1,MINK1,RHOF,PTPN6,VASP,CSNK2A1,IGBP1,N
OD1,STAT2,TBC1D2B,DNM1L,RC3H1,PPP5C,NPC1,SHISA5,RHOBTB
1,TBC1D10B,SEPT4,MIB2,TBX18,BCLAF1,TBC1D14,USP20,GIT2,WAC
,STK4,FGFR1,C2,CFB,DISP1,TAB2,PLEKHG4,SHARPIN,RNF8,MDM2,
FKBP1A,PRKCH,PPM1F,FAM13A,PFDN5,CREB1,NPTN,PLEKHG5,DD
X58,LCP2,SNX13,RHBDF1,NF1,ZEB1,RPS6KA5,G3BP1,PKD2,RB1,LT
biol
BP4,MAPK8IP3,RNF168,PAFAH1B1,SENP2,IL18,MTCH1,ACAP2,USP3
ogic
3,BICD1,RGS3,NR1H3,CYTH2,GRB10,PLK2,FLCN,NRP1,ARHGAP9,FA
al_p
P,PTEN,FYN,RUNX2,IQGAP1,C1R,FBXW7,PHPT1,IKBKB,RQCD1,PXN,
roce
SRGAP2,LTBR,NCOR1,MEF2A,FECH,SETD8,TCTN1,PIAS2,MAPK8,S
ss
H3BP2,MYLK,USP15,HLAF,TRIM28,MAP4K4,CSK,PTPRC,RNF146,CDK6,RARRES2,FLOT1,ARH
GAP29,SGSM3,AAK1,PAK1,EVC,NCK2,LEPROT,RHEB,CTSH,SEMA4D
,CSF1R,DGKZ,C3,SMAD4,TBC1D22A,C1QTNF3,TGFB1I1,GOLPH3,CD
276,NR2C2,LRPAP1,APOL3,FLNA,C1S,GLI3,RASGRF2,EPS15L1,EPN
1,ENG,ARNT,NOX4,BICC1,NRBP2,SLC25A6,STK36,ARHGEF7,ASAP1,
UNC5B,MDFI,ITGA5,RGS2,STAM2,PDGFRB,CARD14,FARP1,RUNX1,S
MARCA4,ADRBK2,GSK3A,ANKRD6,NLGN2,IGF2,PTGIS,PDCD4,SNX1
4,RGL2,CRIPAK,PSMA1,STAT6,PSD3,ROBO2,CSNK1E,CACNB3,NSM
CE4A,BNIP2,NTRK1,SPRED1,TNFRSF10B,DUSP6,TGFBR3,TMEM237,
LMCD1,PDPK1,USF1,STK24,RAPGEF6,C2CD3,UBR5,CC2D1A,GATA2
CADM1,LAMB1,SEPT5,BDNF,CPE,RAB34,HLAcell
DPB1,DPP4,HGS,IL15RA,SYTL4,HLA-C,YIPF1,RGL4,PAM,HLAular
DQA1,AP3S2,ADAM8,RAB35,CD9,CNP,VAMP7,CAMK2D,TNK2,FLG,VT
_co
I1A,FGFR1,HPS4,SEC31A,MDM2,SNAP23,COL12A1,MCFD2,SNX21,L
mpo
GALS3BP,RAB31,GNAI1,BLOC1S5,TPP1,SYTL2,EPN2,ANXA5,ADAM1
nent
5,GARS,SNX17,GGNBP2,SRGAP2,ITGB5,CLTCL1,HLA-
1.17
531
850
5
4.
5
6
E
0
3
1.31
755
358
9
4.
6
9
E
0
G
O:
00
19
63
7
G
O:
00
51
60
4
organophosphate metabolic process
protein maturation
F,ABCA2,RAB8A,DENND4C,CLTB,FLOT1,AAK1,GOPC,NCK2,RAB10,C
TSH,ATP6V0A1,C3,P4HB,TMED3,CLK3,FLNA,RAB5A,TMED2,VEZT,SC
FD1,GAPDH,PDGFRB,VPS51,CANX,PTPN23,CRCP,TLN1,PDIA3,MYO
1E,CORO7,DPP7,CLIC4,CTTNBP2,SEC31B,ZDHHC8,PDPK1,CD63
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,T
AZ,ATP2B1,PLCD1,RAB34,BCL6,CMPK2,GBP3,PLD1,VAPB,GPAA1,P
GS1,SMPD4,MCF2L,ARHGEF12,ATP6V1D,H6PD,PNKP,ARHGEF25,R
GL4,STARD13,FDPS,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1
L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PIGS,PNPO,P
DE7B,TBC1D2B,DNM1L,UPF1,FDXR,PIGG,PDXK,HERC2,CHD6,TBC1
D10B,SEPT4,EFTUD2,CNP,CLN8,PIGN,TBC1D14,TNK2,GIT2,MTG1,R
AB18,NADSYN1,PMS1,ADCY4,PDE4D,PLEKHG4,CHKB,NADK,IDI1,FA
biol
M13A,INO80,GPAT2,RALGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,N
ogic
PR1,G3BP1,RAB31,ADSL,PKD2,GALT,GNAI1,PAFAH1B1,ISYNA1,GPC
al_p
PD1,PDE8A,DDX6,ACAP2,RGS3,GARS,CYTH2,HEXA,PLD6,FLCN,FM
roce
O2,GMDS,ARHGAP9,MTMR14,PTEN,IDH1,IQGAP1,CTNS,SRGAP2,AT
ss
P11B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,I
MPDH1,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,G
NB3,CSF1R,GRPEL2,TBC1D22A,DTYMK,MBOAT2,RAB5A,ATP5A1,TM
ED2,RASGRF2,AK5,ATP8B2,ARHGEF7,ASAP1,REXO2,IDH3B,RGS2,L
PCAT1,PDGFRB,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,L
ONRF3,GSK3A,PCYT1A,PIGO,PPAP2A,MYO1E,GPHN,PGM2,RGL2,C
HD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,UCK1,DHX37,RAPGEF6,ALG9
,PANK3,SMARCAD1,DENND6B,PLA2G16
biol
ogic
CPE,GLG1,ADAM8,C2,CFB,DISP1,MDM2,RHBDD1,FKBP1A,SERPINH
al_p
1,CASP2,IFT172,CTSH,C3,GLI3,PCSK7,LONP2,LMF1,SPCS3,C2CD3
roce
ss
3
1.20
094
162
6
4.
8
1
E
0
3
1.87
119
895
7
4.
8
3
E
0
3
G
O:
00
17
01
6
G
O:
00
19
90
1
G
O:
00
42
17
5
G
O:
00
48
81
3
Ras GTPase binding
mol
ecul
ar_f
unct
ion
RAF1,GAS8,SYTL4,RANBP1,PRKCH,RTKN,SYTL2,BICD1,DAAM1,IQG
AP1,SRGAP2,RAB8A,SGSM3,RANBP9,ERC1,FLNA,RAP1B,RAPGEF6
1.94
497
385
protein kinase binding
mol
ecul
ar_f
unct
ion
UTRN,RAF1,PAM,PDLIM5,PTPN6,EEF1A1,IGBP1,PRKACA,PLK1,CCN
L1,FAM58A,TBC1D14,STK11IP,TPCN2,CCNL2,PTPRK,NPR1,MAPK8IP
3,PTEN,IQGAP1,IKBKB,PXN,MEF2A,PARN,PRKRIP1,RAB8A,CDK5RA
P2,PTPRC,PAK1,RHEB,FLNA,ARHGEF7,RAD54L2,KIF13B,GSK3A,CD
K5RAP1,SPRED1,PKD1,PDPK1,USF1,CDK5RAP3
1.51
719
801
9
nuclear outer membrane-endoplasmic
reticulum membrane network
HLADPB1,MARCH5,UBXN1,PLD1,VAPB,GPAA1,SMPD4,VRK2,DERL2,IL15
RA,HLA-C,XYLT1,HSD17B12,HLAcell DQA1,MPDU1,MARCH6,PIGS,LMAN2,PIGG,SHISA5,NUP210,CLN8,PI
ular GN,VAMP7,CAMK2D,SGK1,CYP2R1,SEC31A,RHBDD1,FKBP1A,SRP9,
_co RHBDF1,EMC3,ALG6,PKD2,EDEM2,SYNE1,FMO2,HERPUD1,TMEM18
mpo 9,NECAB3,CLSTN2,HLAnent F,TMEM66,STX18,EMC4,RAB10,OS9,ELOVL1,TMED3,SLC39A7,MBOA
T2,AUP1,TMED2,RASGRF2,SCFD1,NOX4,EXT1,PDIA5,LPCAT1,EBPL,
MAN1B1,CANX,LRPPRC,YIF1A,RHBDF2,PAPPAAS1,PCYT1A,PIGO,PTGIS,AMFR,LMF1,SEC31B,PLOD2,SPCS3,ALG9
dendrite morphogenesis
biol
ogic
SIPA1L1,MINK1,PDLIM5,ACTR3,SLC11A2,CAPRIN1,PTEN,FYN,MEF2
al_p
A,SEMA4D,PTPRD,FARP1
roce
ss
4.
8
5
E
0
3
4.
8
9
E
0
3
1.34
279
407
9
5.
0
3
E
0
3
2.30
959
414
2
5.
0
6
E
0
3
G
O:
00
44
32
2
G
O:
00
32
04
4
G
O:
00
72
56
3
G
O:
00
02
13
3
G
O:
00
32
endoplasmic reticulum quality control
compartment
cell
ular
_co RHBDD1,MAN1B1
mpo
nent
13.9
933
277
7
DSIF complex
cell
ular
_co SUPT5H,SUPT4H1
mpo
nent
13.9
933
277
7
endothelial microparticle
cell
ular
_co ANXA5,ENG
mpo
nent
13.9
933
277
7
polycystin complex
cell
ular
_co PKD2,PKD1
mpo
nent
13.9
933
277
7
SMC loading complex
cell
ular
NIPBL,MAU2
_co
mpo
13.9
933
277
7
5.
1
0
E
0
3
5.
1
0
E
0
3
5.
1
0
E
0
3
5.
1
0
E
0
3
5.
1
0
E
11
6
G
O:
00
05
96
5
nent
protein farnesyltransferase complex
cell
ular
_co FNTB,CHURC1-FNTB
mpo
nent
cell projection organization
FZD6,CLMN,IGF1R,LAMB1,NPHP3,RAF1,COL9A1,BDNF,COL2A1,ARH
GEF12,CD72,TTLL3,ITGA9,UHMK1,CAPZB,SIPA1L1,MINK1,PDLIM5,A
CTR3,LHX4,VASP,CSNK2A1,SLC11A2,CNP,BBS1,FGFR1,CAPRIN1,KI
biol AA0586,SSH2,CREB1,NPTN,RGMB,RPS6KA5,RB1,MAPK8IP3,BLOC1
ogic S5,PAFAH1B1,USP33,NRP1,PTEN,FYN,IFT172,PXN,SRGAP2,MEF2A,
al_p TCTN1,CACNB1,MYCBP2,MYLK,RAB8A,COL9A3,PTPRC,FLOT1,RAN
roce BP9,WDR35,PAK1,NCK2,RAB10,SEMA6A,SEMA4D,CSF1R,ROBO3,EZ
ss
R,FLNA,RAB5A,GLI3,EXT1,STK36,ARHGEF7,TBCE,ASAP1,UNC5B,NU
P85,PTPRD,ITGA5,DZIP1,CC2D2A,FARP1,KIF13B,PTPN23,TLN1,TRO
VE2,ROBO2,CACNB3,PMP22,NTRK1,TMEM237,SEPT2,STK24,SSH1,C
2CD3,CLASP1
G
O:
00
42
17
6
regulation of protein catabolic process
biol
ogic UBXN1,SMAD7,HGS,RAD23A,ADAM8,CSNK2A1,PRKACA,PLK1,WAC,
al_p MDM2,RHBDD1,RHBDF1,NUB1,PTEN,FYN,FBXW7,SGSM3,SMAD4,FL
roce NA,LPCAT1,GSK3A,CSNK1E
ss
1.79
635
099
9
G
O:
00
51
regulation of cellular component
organization
biol
ogic
al_p
roce
1.25
229
736
6
G
O:
00
30
03
0
CRBN,NOC2L,RAF1,CDK13,BDNF,MARCH5,DPP4,BCL6,SMAD7,HDA
C6,DERL2,ARPC4TTLL3,LEF1,PAX8,BCL2L11,PAM,USP47,CAPZB,PRPF40A,RANBP1,SI
PA1L1,PDLIM5,ACTR3,CSNK2A1,PRKACA,ANAPC4,PLK1,DNM1L,UPF
13.9
933
277
7
1.30
061
090
2
0
3
5.
1
0
E
0
3
5.
1
7
E
0
3
5.
2
9
E
0
3
5.
2
9
E
12
8
G
O:
00
31
32
3
ss
regulation of cellular metabolic process
1,VAMP7,BCLAF1,CAMK2D,TBC1D14,TNK2,TRO,FGFR1,CAPRIN1,SN
CAIP,SGK1,TCHP,PRKCH,PPM1F,INO80,SSH2,NPTN,NPR1,RPS6KA5
,NIPBL,NOL8,RB1,PRMT5,LTBP4,NEXN,PAFAH1B1,ARPC2,STK38L,BI
CD1,NR1H3,PLK2,FLCN,NRP1,IGFBP6,FAP,PTEN,FYN,PHPT1,SNX17,
NCOR1,MEF2A,WASH4P,VILL,MAPK8,MYCBP2,N6AMT1,CSK,CDK5R
AP2,TBCD,WDR61,AAK1,PAK1,NCK2,ACD,SEMA4D,CSF1R,ACTR2,C
3,SMAD4,TGFB1I1,EZR,GOLPH3,FHOD1,RAB5A,NOX4,ERCC1,PHF1,
PTPRD,PDGFRB,CDK11A,SMARCA4,KIF13B,GSK3A,NLGN2,TWF1,IG
F2,CRIPAK,ROBO2,PMP22,CLIC4,NTRK1,BRWD1,TGFBR3,PHF19,SE
NP6,PDPK1,TSG101,STK24,SSH1,UBR5,CLASP1,GATA2
FZD6,USP10,OBFC1,RAB3GAP2,PBX2,KANK2,ACADVL,EIF2B4,RAI1,
PSMB10,IGF1R,TNRC6A,MYO1D,SIRT2,RALGAPA2,MYNN,TRNAU1A
P,NOC2L,RAF1,ZNF131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT
5H,SUPT20H,UBXN1,BCL6,FUBP1,ZNF783,TBX2,MMS19,ZFP91,CNTF
,EEF2K,VAPB,CUX1,EED,FMR1,SMAD7,MCF2L,USP4,HDAC6,ARHGE
F12,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EM
X2,RBPMS,STARD13,ZSCAN31,XBP1,PAM,SNRNP70,RAD23A,APITD
1,UHMK1,USP47,ADAM8,GABPB1,DNAJC10,PCGF6,RANBP1,SIPA1L1
,PTPN6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2
biol
,ANAPC4,PLK1,ZNF446,ASNS,TBC1D2B,PTGES2,UPF1,ZNF621,HDG
ogic
F,NPC1,CCNL1,CHD6,ZC3H12A,TBC1D10B,SEPT4,SYMPK,FAM58A,A
al_p
TG4B,CLN8,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM
roce
1D,ZNF710,GIGYF2,TBC1D14,TNK2,GIT2,WAC,STK4,ZNF142,FUBP3,
ss
ZNF540,FGFR1,HSF4,PAIP1,CAPRIN1,ADCY4,CELF1,PAF1,TAB2,SGK
1,DPF2,CPT1B,RNF8,SEC31A,MDM2,FKBP1A,PRKCH,PPM1F,ZNF595
,TBP,YY1,FAM13A,INO80,GMEB2,PFDN5,CREB1,NPTN,SRP9,FLII,RP
RD1A,DDX58,ZCCHC9,CCNL2,PTPRK,SNX13,RHBDF1,NF1,ZEB1,EIF
4B,NUB1,IFITM3,ASCC2,RGMB,EBF1,MED28,NPR1,ZNF3,RPS6KA5,NI
PBL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,MAPK8IP3,M
ZF1,ZFPM2,TP53BP1,RNF168,PAFAH1B1,ZNF865,SENP2,IL18,PUM2,
TPP1,SYTL2,SUB1,CHMP1A,PDE8A,ACAP2,ZNF558,SH3BP5,ZNF263,
ZNF180,BICD1,ZNF276,RGS3,NR1H3,GRB10,USP7,FLCN,NRP1,ZNF6
0
3
1.10
835
185
5.
3
1
E
0
3
05,ZNF410,ARHGAP9,SAP30BP,MAST2,VPS72,PTEN,SRPK1,RUNX2,I
QGAP1,FBXW7,SMARCD3,HERPUD1,IKBKB,RQCD1,PXN,SRGAP2,RF
X7,NCOR1,MEF2A,FECH,PRKRIP1,SETD8,SMEK1,NECAB3,PIAS2,MA
PK8,MYCBP2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMT
F1,CSK,CDK5RAP2,PTPRC,OAZ1,PSMC6,TBCD,UBP1,WDR61,EBF4,Z
NF148,ZNF76,PSMC4,ARHGAP29,SGSM3,STAG2,SP110,PHKG2,PAK
1,NCK2,TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,CSF1R,ERC1,C3,N
FYC,PIWIL4,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,C1QTNF3,TGFB1I1,DDAH1,INO80E,
ZNF44,CREBZF,ING4,CD276,ZNF687,CDC14B,CLK3,NR2C2,FHOD1,D
NTTIP2,FLNA,IRF9,GLI3,TMED2,MAPK12,CCDC59,DCAF6,AK5,ENG,S
IRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZNF692,GAPDH,ERCC1,PHF1,NR
BP2,STK36,WWP1,ARHGEF7,PHF12,PDIA5,ASAP1,MED6,MDFI,CIRB
P,ZNF554,CIZ1,ITGA5,RGS2,HINFP,NCBP2,LPCAT1,MLX,PDGFRB,TG
S1,CDK11A,GLIS3,ELP6,CARD14,BDP1,FARP1,TNFRSF14,RUNX1,MK
NK2,SMARCA4,NAA16,LRPPRC,YIF1A,RAD54L2,ZNF518B,CLK4,ZNF9
0,ZNF638,PER3,TLN1,GSK3A,ZNF383,NCOR2,SETD2,TWF1,IGF2,PTG
IS,ATXN3,PSTK,PHF21A,PDCD4,SOX13,CHD2,CRIPAK,LONP2,PSMA
1,STAT6,CSNK1E,SON,ZNF138,ZNF705A,CDK5RAP1,BNIP2,NTRK1,T
FAM,SPRED1,TNFRSF10B,BRWD1,SMAD9,HBB,LMF1,DUSP6,TGFBR
3,ZBTB16,BAZ2A,RRP8,VARS,LARS,PHF19,LMCD1,PKD1,PDPK1,TSG
101,USF1,FOXC1,KPNA1,DDAH2,SSH1,CDK5RAP3,RAPGEF6,PABPC
1,UBR5,FASTK,EYA2,SMARCAD1,WNK1,CC2D1A,GATA2
G
O:
00
43
13
0
G
O:
ubiquitin binding
mol
ecul
ar_f
unct
ion
SIRT2,UBXN1,HDAC6,RAD23A,MARK4,TAB2,SHARPIN,RNF168,USP3
3,TSG101,UBR5
2.39
636
115
1
thymidylate kinase activity
mol
ecul
CMPK2,DTYMK
13.5
067
5.
3
6
E
0
3
5.
4
00
04
79
8
G
O:
00
47
52
2
G
O:
00
90
30
2
G
O:
00
36
13
2
G
O:
00
16
40
3
ar_f
unct
ion
15-oxoprostaglandin 13-oxidase activity
mol
ecul
ar_f
unct
ion
mitotic anaphase-promoting complex
activity
mol
ecul
ar_f
unct
ion
13-prostaglandin reductase activity
mol
ecul
ar_f
unct
ion
dimethylargininase activity
mol
ecul
ar_f
unct
ion
628
5
PTGR2,PTGR1
13.5
067
628
5
PLK1,PTEN
13.5
067
628
5
PTGR2,PTGR1
13.5
067
628
5
DDAH1,DDAH2
13.5
067
628
5
8
E
0
3
5.
4
8
E
0
3
5.
4
8
E
0
3
5.
4
8
E
0
3
5.
4
8
E
0
3
G
O:
00
42
90
3
tubulin deacetylase activity
mol
ecul
ar_f
unct
ion
SIRT2,HDAC6
13.5
067
628
5
mitochondrial respiratory chain complex III
biogenesis
biol
ogic
al_p TTC19,BCS1L
roce
ss
13.4
726
324
9
pyridoxal phosphate metabolic process
biol
ogic
al_p PNPO,PDXK
roce
ss
13.4
726
324
9
G
O:
00
42
82
3
pyridoxal phosphate biosynthetic process
biol
ogic
al_p PNPO,PDXK
roce
ss
13.4
726
324
9
G
O:
regulation of male germ cell proliferation
biol
ogic
13.4
726
G
O:
00
97
03
3
G
O:
00
42
82
2
RHBDD1,IL18
5.
4
8
E
0
3
5.
5
0
E
0
3
5.
5
0
E
0
3
5.
5
0
E
0
3
5.
5
20
00
25
4
G
O:
00
46
07
2
G
O:
00
17
06
2
G
O:
00
06
25
8
G
O:
00
06
23
3
al_p
roce
ss
324
9
dTDP metabolic process
biol
ogic
al_p CMPK2,DTYMK
roce
ss
13.4
726
324
9
respiratory chain complex III assembly
biol
ogic
al_p TTC19,BCS1L
roce
ss
13.4
726
324
9
UDP-glucose catabolic process
biol
ogic
al_p GALT,GSK3A
roce
ss
13.4
726
324
9
dTDP biosynthetic process
biol
ogic
al_p CMPK2,DTYMK
roce
ss
13.4
726
324
9
0
E
0
3
5.
5
0
E
0
3
5.
5
0
E
0
3
5.
5
0
E
0
3
5.
5
0
E
0
3
G
O:
00
07
09
2
G
O:
00
00
08
8
G
O:
00
34
55
1
G
O:
00
46
12
8
activation of mitotic anaphase-promoting
complex activity
biol
ogic
al_p PLK1,PTEN
roce
ss
13.4
726
324
9
mitotic prophase
biol
ogic
al_p PLK1,GORASP1
roce
ss
13.4
726
324
9
mitochondrial respiratory chain complex III
assembly
biol
ogic
al_p TTC19,BCS1L
roce
ss
13.4
726
324
9
purine ribonucleoside metabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
biol TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
ogic KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
al_p ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
roce AB18,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,DD
ss
X58,SNX13,NF1,RTKN,G3BP1,RAB31,ADSL,GNAI1,PAFAH1B1,DDX6,
ACAP2,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11
B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,PSMC6,TBCD,IMPDH1,
1.25
629
049
5.
5
0
E
0
3
5.
5
0
E
0
3
5.
5
0
E
0
3
5.
5
1
E
0
3
G
O:
00
22
60
7
G
O:
00
06
41
2
G
O:
00
cellular component assembly
SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GR
PEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARH
GEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8
,LONRF3,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX
37,RAPGEF6,MTO1,PANK3,DENND6B
CRBN,CADM1,IGF1R,RAF1,F11R,SFSWAP,BDNF,TAZ,SART1,RAB34,
MMS19,SHMT2,GPAA1,CLNS1A,NUP98,SMAD7,HDAC6,TTLL3,ARPC4
TTLL3,GLS,BCL2L11,STARD9,COG4,PAM,DDX23,CAPZB,CD9,PDLIM5
,ACTR3,VASP,NOD1,PRKACA,TTC19,DNM1L,RC3H1,PPP5C,ATG4B,B
CLAF1,BBS1,TBC1D14,HSF4,DISP1,CELF1,SNCAIP,SF3A2,SHARPIN,
biol MDM2,FKBP1A,PRKCH,PPM1F,TLN2,INO80,SSH2,PTPRK,MAGI1,PIH
ogic 1D1,ATG12,ADSL,MITF,RB1,PRMT5,PUM2,ARPC2,DDX6,BICD1,PLD6,
al_p FLCN,PTEN,IFT172,PXN,SRGAP2,NCOR1,TNS1,FECH,ERAL1,WASH4
roce P,VILL,MYLK,RAB8A,TRIM28,TBCD,TSPAN4,COX14,ZNF148,GOPC,R
ss
ANBP9,WDR35,ATPAF2,PARD6G,PAK1,NCK2,TCF4,ACD,ACTR2,SRS
F10,SMAD4,C1QTNF3,EZR,CENPT,FHOD1,FLNA,RAB5A,HGSNAT,BC
S1L,TMED2,NOX4,STK36,ARHGEF7,CIRBP,NUP85,NUBP1,HAUS5,PT
PRD,ITGA5,NCBP2,TGS1,DZIP1,CC2D2A,FARP1,KCTD2,TLN1,SNRPE
,NLGN2,TWF1,AMFR,ROBO2,KCTD17,TFAM,SHPRH,ATG3,HBB,TGFB
R3,TMEM237,LIMS2,CD151,BAZ2A,SEPT2,UQCRH,SENP6,PDPK1,SS
H1,FMOD,C2CD3,SMARCAD1
1.22
246
948
9
translation
EIF2B4,TNRC6A,TRNAU1AP,TARS,EEF2K,FMR1,NARS,UHMK1,EEF1
biol
A1,UPF3A,UPF1,GIGYF2,RARS,ZNF540,PAIP1,CAPRIN1,CELF1,RNF8
ogic
,SRP9,RPL27,EIF4B,RPL9,RSL1D1,RNF168,PUM2,GARS,MRPS7,RPL
al_p
24,RPL37A,FECH,FARSA,PPA2,NCK2,PIWIL4,RPL4,EIF3M,MRPL49,G
roce
APDH,MTRF1L,TBCE,CIRBP,RGS2,NCBP2,MKNK2,RPLP0,MRPL3,PS
ss
TK,CARS2,SPCS3,EIF3I,VARS,LARS,PABPC1
1.42
524
854
7
small molecule metabolic process
biol
ogic
al_p
1.14
343
375
CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,PSMB10,CKB,GK5,PTS,MY
O1D,EPHX2,RALGAPA2,TARS,RAF1,SEPT5,SLC16A3,TAZ,SIN3B,ATP
2B1,RAB34,ST3GAL1,BCL6,CMPK2,ENOSF1,GBP3,SHMT2,PLD1,VAP
5.
5
6
E
0
3
5.
6
1
E
0
3
5.
6
2
44
28
1
G
O:
00
46
purine ribonucleoside catabolic process
roce B,PGS1,NUP98,AMT,SMPD4,MCF2L,ARHGEF12,ATP6V1D,NARS,H6P
ss
D,PNKP,GLS,PAX8,PSMB9,ARHGEF25,RGL4,XYLT1,STARD13,FDPS,
PAM,ABCC1,HSD17B12,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,D
DX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,PRKACA,RPP14,DHX9,P
NPO,PDE7B,ASNS,TBC1D2B,DNM1L,TXNL1,PTGES2,UPF1,FDXR,PD
XK,NPC1,HERC2,CHD6,NUP210,TBC1D10B,SEPT4,EFTUD2,CNP,CLN
8,GCDH,SLC16A1,TBC1D14,TNK2,GIT2,MTG1,RARS,ALDH18A1,RAB1
8,ERH,NADSYN1,PMS1,ADCY4,SNCAIP,PDE4D,PLEKHG4,CPT1B,CH
KB,NADK,IDI1,CYP2R1,IDH3G,FAM13A,INO80,GPAT2,RALGPS2,NAG
K,PLEKHG5,QSOX1,DDX58,ALDH6A1,SNX13,NF1,ACAA1,RTKN,NPR1
,G3BP1,RAB31,ADSL,ST3GAL4,PKD2,GALT,GNAI1,TXNDC5,PAFAH1B
1,ISYNA1,GPCPD1,STARD3,PDE8A,AACS,DDX6,ACAP2,RGS3,NR1H3
,GARS,CYTH2,HEXA,PLD6,FLCN,PTGR2,FMO2,GMDS,ARHGAP9,UST
,MTMR14,PTEN,ALDH1A3,IDH1,IQGAP1,LGMN,SMARCD3,CTNS,SNX
17,SRGAP2,NCOR1,ATP11B,OXCT1,FECH,COX7A2L,SMEK1,DDX41,
RNF213,ABCA2,DENND4C,MAP4K4,ITPA,OAZ1,PSMC6,TBCD,IMPDH
1,SKIV2L2,NUP37,FARSA,PSMC4,ARHGAP29,SGSM3,GOPC,PPA2,P
HKG2,LEPR,RHEB,SEMA4D,GNB3,C3,ALDH3B1,P4HB,HSD17B4,ELO
VL1,GRPEL2,TBC1D22A,C1QTNF3,DDAH1,DTYMK,MTRR,MBOAT2,SL
C23A2,DLST,RAB5A,CA5B,HGSNAT,ATP5A1,TMED2,THNSL2,NDUFV
1,NDUFS2,RASGRF2,AK5,GUSB,B4GALT4,NOX4,ETFA,EXT1,GAPDH,
B3GAT3,SLC25A6,SDHA,ATP8B2,ARHGEF7,PDIA5,ASAP1,REXO2,NU
P85,IDH3B,PTGR1,RGS2,LPCAT1,MLX,EBPL,TGS1,RAD51B,FARP1,R
AP1B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A,NCOR2,FPGS,PCYT
1A,PPAP2A,PDIA3,PTGIS,MYO1E,D2HGDH,GPHN,PGM2,RGL2,CHD2,
LONP2,PSMA1,CARS2,ACIN1,PSD3,BNIP2,NTRK1,PHKG1,HBB,LMF1,
UCK1,SPCS3,VARS,LARS,DHX37,UQCRH,DDAH2,ACAN,RAPGEF6,F
MOD,MTO1,PANK3,SMARCAD1,DENND6B,PLA2G16
biol CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
ogic RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
al_p TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
roce KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
4
E
0
3
1.26
525
592
1
5.
9
2
E
13
0
G
O:
00
06
15
2
G
O:
00
42
27
8
ss
purine nucleoside catabolic process
purine nucleoside metabolic process
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
DENND4C,MAP4K4,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM
3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,T
MED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RA
P1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
biol ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
ogic AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
al_p X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
roce CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
ss
DENND4C,MAP4K4,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM
3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,T
MED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RA
P1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
biol
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ogic
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
al_p
AB18,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,DD
roce
X58,SNX13,NF1,RTKN,G3BP1,RAB31,ADSL,GNAI1,PAFAH1B1,DDX6,
ss
ACAP2,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11
B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,PSMC6,TBCD,IMPDH1,
SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GR
0
3
1.26
525
592
1
5.
9
2
E
0
3
1.25
326
813
9
5.
9
3
E
0
3
PEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARH
GEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8
,LONRF3,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX
37,RAPGEF6,MTO1,PANK3,DENND6B
G
O:
00
71
48
2
G
O:
00
18
19
3
G
O:
00
05
78
3
cellular response to light stimulus
peptidyl-amino acid modification
endoplasmic reticulum
biol
ogic
al_p NOC2L,USP47,MDM2,RHBDD1,YY1,INO80,PTPRK,CRIP1,FBXW7
roce
ss
NOC2L,PPIL2,RAF1,CNTF,SMAD7,HDAC6,EHMT1,LEF1,UHMK1,PTPN
6,PRKACA,PLK1,DR1,CAMK2D,TNK2,STK4,FGFR1,SEC31A,MDM2,FK
biol
BP1A,PPM1F,MCFD2,PHF15,FKBP10,RPS6KA5,ALG6,ST3GAL4,PRMT
ogic
5,EDEM2,GALNT2,NTMT1,FLCN,NRP1,FYN,FBXW7,PXN,SETD8,MAP
al_p
K8,MAN1A2,PTPRC,AGBL5,WDR61,PAK1,SEMA4D,CSF1R,P4HB,ING
roce
4,CLK3,MSL1,MGAT5,MAPK12,B4GALT4,GAPDH,ITGA5,MAN2A2,PDG
ss
FRB,MAN1B1,TNFRSF14,CANX,SMARCA4,CLK4,TTLL11,SETD2,KAN
SL3,PDIA3,IGF2,SPRED1,SIRT3,PKD1,PDPK1,ALG9,GATA2
MYO1D,LEPRE1,COL9A1,COL2A1,HLADPB1,MARCH5,UBXN1,PLD1,VAPB,GPAA1,PGS1,SMPD4,VRK2,DERL
2,IL15RA,H6PD,HLA-C,XYLT1,HSD17B12,HLADQA1,MPDU1,DNAJC10,MARCH6,PIGS,LMAN2,COL16A1,PIGG,NPC1,
cell SHISA5,NUP210,CLN8,PIGN,VAMP7,CAMK2D,PLCB4,COL14A1,RNAS
ular ET2,SGK1,CYP2R1,SEC31A,RHBDD1,COL12A1,FKBP1A,MCFD2,SRP
_co 9,RHBDF1,SERPINH1,EMC3,COL18A1,FKBP10,ALG6,PKD2,MAPK8IP
mpo 3,DHRS1,TXNDC5,EDEM2,FAM172A,FMO2,SRPK1,FBXW7,HERPUD1,
nent ATP11B,TMEM189,NECAB3,CLSTN2,CACNB1,DDX41,OSBPL3,HLAF,ZFAND2B,COL9A3,TMEM66,STX18,EMC4,NCK2,RAB10,OS9,P4HB,
ELOVL1,TMED3,SLC39A7,MBOAT2,AUP1,LRPAP1,TMED2,RASGRF2,
SCFD1,NOX4,EXT1,PDIA5,LPCAT1,COL8A1,EBPL,MAN1B1,CANX,YIF
1A,SUMF2,RHBDF2,PAPPA-
2.63
594
983
6
5.
9
9
E
0
3
1.34
353
121
8
6.
0
3
E
0
3
1.25
169
675
6.
1
0
E
0
3
G
O:
00
05
78
9
G
O:
00
07
40
9
G
O:
00
30
69
5
G
O:
00
00
endoplasmic reticulum membrane
axonogenesis
GTPase regulator activity
cytoplasmic ubiquitin ligase complex
AS1,PCYT1A,PIGO,PDIA3,COL13A1,PTGIS,AMFR,CRIPAK,CACNA2D1
,LMF1,TGFBR3,SEC31B,PLOD2,KDELC2,SPCS3,PPT2,CES2,ALG9,PL
A2G16
HLADPB1,MARCH5,UBXN1,PLD1,VAPB,GPAA1,SMPD4,VRK2,DERL2,IL15
RA,HLA-C,XYLT1,HSD17B12,HLAcell DQA1,MPDU1,MARCH6,PIGS,LMAN2,PIGG,SHISA5,NUP210,CLN8,PI
ular GN,VAMP7,CAMK2D,SGK1,CYP2R1,SEC31A,RHBDD1,FKBP1A,SRP9,
_co RHBDF1,EMC3,ALG6,PKD2,EDEM2,FMO2,HERPUD1,TMEM189,NECA
mpo B3,CLSTN2,HLAnent F,TMEM66,STX18,EMC4,RAB10,OS9,ELOVL1,TMED3,SLC39A7,MBOA
T2,AUP1,TMED2,RASGRF2,SCFD1,NOX4,EXT1,PDIA5,LPCAT1,EBPL,
MAN1B1,CANX,YIF1A,RHBDF2,PAPPAAS1,PCYT1A,PIGO,PTGIS,AMFR,LMF1,SEC31B,PLOD2,SPCS3,ALG9
FZD6,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,ARHGEF12,CD72,I
biol TGA9,SIPA1L1,LHX4,VASP,CSNK2A1,CNP,FGFR1,SSH2,CREB1,RGM
ogic B,RPS6KA5,MAPK8IP3,PAFAH1B1,USP33,NRP1,PTEN,FYN,SRGAP2,
al_p TCTN1,CACNB1,MYCBP2,RAB8A,COL9A3,PTPRC,FLOT1,RANBP9,PA
roce K1,NCK2,RAB10,SEMA6A,SEMA4D,ROBO3,EZR,GLI3,EXT1,TBCE,UN
ss
C5B,ITGA5,KIF13B,TLN1,ROBO2,CACNB3,NTRK1,STK24,SSH1,CLAS
P1
RAB3GAP2,EIF2B4,RALGAPA2,MCF2L,ARHGEF12,ARHGEF25,RGL4,
mol STARD13,RANBP1,SIPA1L1,KRIT1,MINK1,TBC1D2B,HERC2,TBC1D10
ecul B,TBC1D14,TNK2,GIT2,PLEKHG4,FAM13A,RALGPS2,PLEKHG5,NF1,R
ar_f TKN,ACAP2,RGS3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,DENND4C,MA
unct P4K4,TBCD,ARHGAP29,SGSM3,GOPC,TBC1D22A,RASGRF2,ARHGE
ion
F7,ASAP1,RGS2,FARP1,DOCK8,RGL2,PSD3,BNIP2,RAPGEF6,DENND
6B
cell
ular
USP33,OS9,ATG3
_co
mpo
1.33
786
337
9
1.40
873
533
7
1.44
715
316
2
6.99
666
388
7
6.
1
1
E
0
3
6.
1
2
E
0
3
6.
1
2
E
0
3
6.
1
8
E
15
3
G
O:
00
31
98
4
G
O:
00
45
84
3
G
O:
19
01
86
2
G
O:
00
31
40
1
nent
organelle subcompartment
cell
ular
ST3GAL1,FKBP1A,ST3GAL4,GOLGA8B,GOLGA8A,GALNT2,NECAB3,F
_co
UT4,TMED3,GOLPH3,TMED2,B4GALT4,SCFD1
mpo
nent
2.16
563
406
negative regulation of striated muscle tissue
development
biol
ogic
al_p SIRT2,BDNF,LUC7L,LEF1,GSK3A
roce
ss
3.96
253
896
9
negative regulation of muscle tissue
development
biol
ogic
al_p SIRT2,BDNF,LUC7L,LEF1,GSK3A
roce
ss
3.96
253
896
9
positive regulation of protein modification
process
ACADVL,PSMB10,IGF1R,RAF1,ZFP91,CNTF,VAPB,SMAD7,PSMB9,RB
PMS,XBP1,APITD1,ADAM8,NOD1,PRKACA,ANAPC4,PLK1,ASNS,HDG
biol
F,SEPT4,SYMPK,TNK2,STK4,FGFR1,ADCY4,TAB2,SEC31A,FKBP1A,N
ogic
PTN,RPS6KA5,NIPBL,PKD2,LMNA,MAPK8IP3,SENP2,TPP1,FLCN,NRP
al_p
1,PTEN,IQGAP1,FBXW7,HERPUD1,PXN,NCOR1,CSK,PTPRC,PSMC6,
roce
WDR61,PSMC4,PAK1,SEMA4D,CSF1R,C3,SMAD4,CDC14B,ENG,ARN
ss
T,NOX4,PHF1,PDIA5,MDFI,ITGA5,PDGFRB,CARD14,TNFRSF14,YIF1A
,TLN1,GSK3A,IGF2,PSMA1,NTRK1,TNFRSF10B,PHF19,PKD1,PDPK1
1.32
953
610
1
0
3
6.
4
2
E
0
3
6.
5
0
E
0
3
6.
5
0
E
0
3
6.
6
0
E
0
3
G
O:
00
00
38
7
spliceosomal snRNP assembly
biol
ogic
al_p SART1,CLNS1A,PRMT5,SRSF10,NCBP2,TGS1,SNRPE
roce
ss
3.04
220
733
7
RS domain binding
mol
ecul
ar_f
unct
ion
LUC7L,SRSF10,SON
6.75
338
142
5
metanephric S-shaped body
morphogenesis
biol
ogic
al_p PAX8,PKD2,PDGFRB
roce
ss
6.73
631
624
7
G
O:
00
45
99
0
carbon catabolite regulation of transcription
biol
ogic
al_p CHMP1A,RRP8,USF1
roce
ss
6.73
631
624
7
G
O:
00
42
regulation of Golgi to plasma membrane
protein transport
biol
ogic
CSK,GOPC,VAMP4
al_p
roce
6.73
631
624
7
G
O:
00
50
73
3
G
O:
00
72
28
4
6.
6
1
E
0
3
6.
8
3
E
0
3
6.
8
8
E
0
3
6.
8
8
E
0
3
6.
8
8
E
99
6
G
O:
00
34
08
6
G
O:
00
50
96
6
G
O:
00
09
13
3
G
O:
00
35
52
0
ss
maintenance of sister chromatid cohesion
biol
ogic
al_p NIPBL,RB1,MAU2
roce
ss
6.73
631
624
7
detection of mechanical stimulus involved in
sensory perception of pain
biol
ogic
al_p IL18,FYN,NTRK1
roce
ss
6.73
631
624
7
nucleoside diphosphate biosynthetic
process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
6.73
631
624
7
monoubiquitinated protein deubiquitination
biol
ogic
al_p USP47,USP15,ATXN3
roce
ss
6.73
631
624
7
0
3
6.
8
8
E
0
3
6.
8
8
E
0
3
6.
8
8
E
0
3
6.
8
8
E
0
3
G
O:
00
34
08
8
G
O:
00
21
52
3
G
O:
00
07
09
0
G
O:
00
30
19
9
G
O:
00
32
maintenance of mitotic sister chromatid
cohesion
biol
ogic
al_p NIPBL,RB1,MAU2
roce
ss
6.73
631
624
7
somatic motor neuron differentiation
biol
ogic
al_p LHX4,CLN8,TCTN1
roce
ss
6.73
631
624
7
regulation of S phase of mitotic cell cycle
biol
ogic
al_p BCL6,PAF1,RB1,CHMP1A,CUL4A,SMARCA4
roce
ss
3.36
815
812
3
collagen fibril organization
biol
ogic
al_p LEPRE1,COL2A1,COL14A1,COL12A1,SERPINH1,NF1,FOXC1,ACAN
roce
ss
2.76
361
692
2
small conjugating protein binding
mol
ecul
ar_f
unct
2.22
028
978
3
SIRT2,UBXN1,HDAC6,RAD23A,MARK4,HERC2,TAB2,SHARPIN,RNF16
8,USP33,TSG101,UBR5
6.
8
8
E
0
3
6.
8
8
E
0
3
6.
9
5
E
0
3
6.
9
8
E
0
3
6.
9
9
E
18
2
G
O:
00
07
16
0
G
O:
00
10
49
8
G
O:
00
51
24
7
G
O:
00
51
02
ion
cell-matrix adhesion
biol
ogic UTRN,BCL6,BCL2L11,MINK1,PPM1F,THBS3,PTPRK,NF1,ITGA3,PLEK
al_p HA2,ADAM15,PTEN,PXN,CDK6,TRPM7,PPFIA1,ITGA11,COL13A1,PKD
roce 1,PDPK1
ss
1.80
840
704
6
proteasomal protein catabolic process
biol
ogic
al_p
roce
ss
1.61
448
901
8
positive regulation of protein metabolic
process
GTPase binding
CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,DERL2,PSMB9,RAD23A,
DNAJC10,PRKACA,ANAPC4,PLK1,WAC,MDM2,RHBDD1,RHBDF1,NU
B1,PTEN,FBXW7,PSMC6,PSMC4,OS9,WWP1,MAN1B1,ATXN3,AMFR,
PSMA1,CSNK1E
ACADVL,PSMB10,IGF1R,RAF1,ZFP91,CNTF,VAPB,SMAD7,PSMB9,RB
PMS,XBP1,APITD1,UHMK1,ADAM8,CSNK2A1,UPF3A,NOD1,PRKACA,
ANAPC4,PLK1,ASNS,HDGF,SEPT4,SYMPK,TNK2,STK4,FGFR1,PAIP1,
biol
ADCY4,TAB2,SEC31A,MDM2,RHBDD1,FKBP1A,NPTN,NUB1,RPS6KA5
ogic
,NIPBL,PKD2,LMNA,MAPK8IP3,SENP2,TPP1,NR1H3,FLCN,NRP1,PTE
al_p
N,IQGAP1,FBXW7,HERPUD1,PXN,NCOR1,CSK,PTPRC,PSMC6,WDR6
roce
1,PSMC4,SGSM3,PAK1,SEMA4D,CSF1R,C3,SMAD4,CD276,CDC14B,E
ss
NG,ARNT,NOX4,PHF1,PDIA5,MDFI,CIRBP,ITGA5,LPCAT1,PDGFRB,C
ARD14,TNFRSF14,YIF1A,TLN1,GSK3A,IGF2,PSMA1,CSNK1E,NTRK1,
TNFRSF10B,PHF19,PKD1,PDPK1,PABPC1
mol
ecul RAF1,GAS8,MARCH5,SYTL4,RANBP1,PRKCH,RTKN,SYTL2,BICD1,DA
ar_f AM1,IQGAP1,SRGAP2,RAB8A,SGSM3,RANBP9,GNB3,ERC1,FLNA,RA
unct P1B,RAPGEF6
ion
0
3
7.
0
7
E
0
3
7.
1
6
E
0
3
1.29
070
429
7
7.
2
1
E
0
3
1.80
090
171
3
7.
3
9
E
-
0
G
O:
00
48
46
8
G
O:
00
09
11
7
0
3
cell development
nucleotide metabolic process
FZD6,EIF2B4,CLMN,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,BCL
6,CNTF,SMAD7,ARHGEF12,CD72,LEF1,PAX8,ITGA9,XBP1,UHMK1,CD
9,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,CSNK2A1,PRKACA,SE
PT4,SLC11A2,CNP,FGFR1,HSF4,CAPRIN1,CELF1,PDE4D,PAF1,RNF8
,PRKCH,SSH2,CREB1,NPTN,NF1,ZEB1,RGMB,COL18A1,MED28,RPS6
KA5,NIPBL,LMNA,RB1,MAPK8IP3,BLOC1S5,PAFAH1B1,MTCH1,ARPC
biol
2,ADAM15,USP33,HEXA,PLD6,NRP1,VPS72,PTEN,FYN,SRPK1,RUNX
ogic
2,IQGAP1,SMARCD3,SRGAP2,MEF2A,TCTN1,CACNB1,MYCBP2,PBX
al_p
3,RAB8A,AFF4,TRIM28,CDK5RAP2,COL9A3,PTPRC,CDK6,FLOT1,STA
roce
G2,GOPC,RANBP9,PAK1,NCK2,RAB10,SEMA6A,TCF4,SEMA4D,HSD1
ss
7B4,ROBO3,SMAD4,TGFB1I1,EZR,FLNA,GLI3,ENG,TCF12,EXT1,ERC
C1,TBCE,MED6,UNC5B,PTPRD,ITGA5,PDGFRB,DZIP1,FARP1,RUNX1
,SMARCA4,KIF13B,TLN1,GSK3A,SETD2,MYO1E,GPHN,ROBO2,CACN
B3,PMP22,CLIC4,CDK5RAP1,BNIP2,NTRK1,TGFBR3,ZBTB16,SEPT2,
PDPK1,FOXC1,ACAN,STK24,SSH1,CDK5RAP3,WNK1,CLASP1,TENM4
,GATA2
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,CMPK2,GBP3,MCF2L,ARHGEF12,ATP6V1D,H6P
D,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,
RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9
,PDE7B,TBC1D2B,DNM1L,UPF1,FDXR,HERC2,CHD6,TBC1D10B,SEP
biol
T4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB18,NADSYN1,PMS1,
ogic
ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,
al_p
DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB31,ADSL,PKD2,GALT,GN
roce
AI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,GARS,CYTH2,FLCN,FMO2
ss
,GMDS,ARHGAP9,IDH1,IQGAP1,CTNS,SRGAP2,ATP11B,DDX41,RNF2
13,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,P
SMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC
1D22A,DTYMK,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHG
EF7,ASAP1,REXO2,IDH3B,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,D
1.21
836
388
2
7.
4
1
E
0
3
1.21
609
835
5
7.
4
6
E
0
3
HX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LONP2,ACIN1,PS
D3,BNIP2,NTRK1,UCK1,DHX37,RAPGEF6,PANK3,SMARCAD1,DENND
6B
G
O:
00
34
33
0
G
O:
00
42
45
4
cell junction organization
ribonucleoside catabolic process
G
O:
00
44
42
7
chromosomal part
G
O:
ribonucleoside metabolic process
biol
ogic CADM1,F11R,SMAD7,CD9,VASP,PRKACA,PRKCH,PPM1F,TLN2,PTPR
al_p K,FLCN,PTEN,PXN,TNS1,CSK,TBCD,PARD6G,CSF1R,FLNA,ITGA5,TL
roce N1,NLGN2,LIMS2,CD151,PDPK1
ss
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
biol ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
ogic AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
al_p X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
roce CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
ss
DENND4C,MAP4K4,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM
3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,T
MED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RA
P1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
OBFC1,CBX5,BCL6,NUP98,EED,DYNC1I1,APITD1,CSNK2A1,PLK1,UP
cell F1,RNF8,TBP,YY1,INO80,CREB1,RB1,USP3,TP53BP1,RNF168,PAFAH
ular 1B1,NR1H3,RUNX2,SMARCD3,NCOR1,PPP1R10,MEF2A,TRIM28,DSN
_co 1,WDR61,NUP37,STAG2,ACD,HMGN2,INO80E,CENPT,FLNA,SUN2,SI
mpo RT7,ERCC1,PHF1,PHF12,NUP85,NCAPD3,SMARCA4,NCOR2,MAU2,S
nent TAT6,NSMCE4A,SHPRH,BAZ2A,RRP8,SEPT2,FOXC1,SMARCAD1,CL
ASP1
biol CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
ogic RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
1.67
570
055
9
7.
5
9
E
0
3
1.25
434
854
2
7.
6
3
E
0
3
1.39
426
273
1
1.24
117
7.
6
3
E
0
3
7.
7
00
09
11
9
G
O:
00
51
17
2
G
O:
00
48
03
7
G
O:
00
negative regulation of nitrogen compound
metabolic process
al_p TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
roce KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ss
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
AB18,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,DD
X58,SNX13,NF1,RTKN,G3BP1,RAB31,ADSL,GNAI1,PAFAH1B1,DDX6,
ACAP2,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11
B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,PSMC6,TBCD,IMPDH1,
SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GR
PEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARH
GEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8
,LONRF3,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,UCK
1,DHX37,RAPGEF6,MTO1,PANK3,DENND6B
KANK2,SIRT2,NOC2L,SFSWAP,SIN3B,CBX5,SUPT5H,BCL6,TBX2,CU
X1,EED,SMAD7,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,USP
47,PCGF6,IGBP1,PLK1,HDGF,ZC3H12A,TBX18,DR1,BCLAF1,ZNF540,
biol
FGFR1,HSF4,PAF1,MDM2,PPM1F,YY1,PFDN5,CREB1,PTPRK,ZEB1,IF
ogic
ITM3,RPS6KA5,NIPBL,RB1,PRMT5,ZFPM2,CHMP1A,ZNF263,NR1H3,F
al_p
LCN,VPS72,RUNX2,FBXW7,NCOR1,MEF2A,SETD8,TRIM28,UBP1,ZNF
roce
148,STAG2,TCF4,ACD,SEMA4D,SRSF10,SMAD4,CREBZF,ING4,GLI3,
ss
ENG,SIRT7,ERCC1,WWP1,PHF12,MDFI,HINFP,LPCAT1,MLX,GLIS3,S
MARCA4,PER3,GSK3A,NCOR2,PTGIS,PHF21A,PDCD4,STAT6,ZBTB1
6,BAZ2A,RRP8,LMCD1,TSG101,PABPC1,UBR5,CC2D1A,GATA2
952
9
1.27
852
532
8
cofactor binding
mol
ecul
ar_f
unct
ion
ACADVL,SIRT2,SHMT2,TYW1B,H6PD,PNPO,ASNS,FDXR,PDXK,GCD
H,IDH3G,ALDH6A1,ACBD4,FMO2,GMDS,ALDH1A3,IDH1,MTRR,THNS
L2,NDUFV1,NDUFS2,SIRT7,NOX4,ETFA,GAPDH,SDHA,IDH3B,D2HGD
H,SIRT3,MTO1
1.58
903
092
3
anatomical structure morphogenesis
biol
ogic
al_p
FZD6,PBX2,CADM1,PSMB10,IGF1R,LAMB1,NPHP3,RAF1,COL9A1,BD
NF,CPE,PLCD1,COL2A1,SUPT20H,MARCH5,BCL6,TBX2,CNTF,SMAD
7,GLG1,ARHGEF12,RNH1,CD72,TTLL3,LEF1,PAX8,ITGA9,ADAMTS1,B
1.17
845
721
1
E
0
3
7.
8
5
E
0
3
7.
8
6
E
0
3
7.
9
0
09
65
3
G
O:
00
16
79
1
G
O:
00
06
88
6
roce CL2L11,CPM,PAM,ADAM8,CAPZB,PRPF40A,CD9,SIPA1L1,KRIT1,MIN
ss
K1,PDLIM5,ACTR3,LHX4,VASP,CSNK2A1,PRKACA,SDCCAG8,JAG2,D
NM1L,ZC3H12A,SLC11A2,AAMP,CNP,TBX18,BBS1,STK4,FGFR1,CAP
RIN1,PAF1,KIAA0586,FKBP1A,YY1,SSH2,THBS3,CREB1,NF1,ZEB1,C
RIP1,RGMB,COL18A1,NPR1,RPS6KA5,NIPBL,PKD2,SLC12A6,RB1,MA
PK8IP3,ZFPM2,PAFAH1B1,IL18,ARPC2,ADAM15,USP33,BICD1,HEXA,
NRP1,STX2,PTEN,FYN,ALDH1A3,RUNX2,FBXW7,SMARCD3,IFT172,P
XN,SRGAP2,MEF2A,TCTN1,SSBP1,CACNB1,MYCBP2,CLTCL1,MYLK,
RAB8A,TRIM28,COL9A3,PTPRC,UBP1,FLOT1,RANBP9,WDR35,PAK1,
EVC,NCK2,RAB10,SEMA6A,CTSH,ACD,SEMA4D,CSF1R,C3,ROBO3,S
S18,SMAD4,TGFB1I1,DDAH1,LMBR1,EZR,FLNA,GLI3,TMED2,ENG,NO
X4,EXT1,ERCC1,GAA,STK36,TBCE,ASAP1,UNC5B,MDFI,PTPRD,ITGA
5,PDGFRB,COL8A1,DZIP1,CC2D2A,FARP1,RUNX1,SMARCA4,KIF13B,
PTPN23,TLN1,GSK3A,ANKRD6,NCOR2,FPGS,SETD2,COL13A1,PTGIS
,TROVE2,MYO1E,SOX13,STAT6,TANC1,ROBO2,CACNB3,PMP22,CLI
C4,NTRK1,BRWD1,SMAD9,DUSP6,TGFBR3,TMEM237,ZBTB16,SEPT2
,PKD1,FOXC1,ACAN,STK24,SSH1,C2CD3,EYA2,CLASP1,TENM4,GAT
A2
6
phosphatase activity
mol
ecul
ar_f
unct
ion
MYO1D,EPHX2,PTPN22,PNKP,PTPN6,CSNK2A1,IGBP1,PPP5C,FKBP
1A,MTMR11,PPM1F,SSH2,ZCCHC9,PTPRK,NTPCR,NEDD8MDP1,MDP1,SYTL2,TENC1,MTMR14,PTEN,PHPT1,PTP4A2,PTPRF,P
PP1R10,MEF2A,PTPRS,PTPRC,MTMR9,SEMA4D,TIMM50,CDC14B,PT
PRD,PDGFRB,PTPN4,FARP1,PTPN23,PPAP2A,SPRED1,DUSP6,SSH1
,EYA2,WNK1
1.45
927
337
3
intracellular protein transport
biol
ogic
al_p
roce
ss
RAB3GAP2,BCL6,NUP98,HDAC6,HGS,DERL2,SYTL4,RBPMS,AP3S2,
UHMK1,KPNA6,PRKACA,NUTF2,HERC2,VAMP7,BBS1,VTI1A,HPS4,TI
MM23,MDM2,SRP9,DDX58,RPL27,SNX13,AP4B1,NF1,RPL9,RAB31,PK
D2,LMNA,STX16,SYTL2,GCC2,RPL24,RPL37A,STX2,SNX17,KPNB1,P
PP1R10,CACNB1,CLTCL1,CSK,STX18,CLTB,GOPC,RAB10,VPS45,AC
D,TIMM50,OS9,SMAD4,GRPEL2,C1QTNF3,RPL4,FLNA,GLI3,TMED2,V
TI1B,SLC25A6,VAMP4,MDFI,STAM2,RPLP0,KIF13B,PDIA3,LONP2,AT
1.33
039
903
6
E
0
3
7.
9
4
E
0
3
7.
9
6
E
0
3
G3,SPCS3,PKD1,KPNA1,UBR5
G
O:
00
06
41
8
tRNA aminoacylation for protein translation
G
O:
00
51
64
1
cellular localization
G
O:
00
central nervous system development
biol
ogic
al_p TARS,NARS,RARS,GARS,FARSA,PPA2,CARS2,VARS,LARS
roce
ss
SLC25A37,RAB3GAP2,CADM1,RALGAPA2,BTN3A1,NOC2L,NLRP1,SE
PT5,GAS8,BDNF,CPE,MARCH5,BCL6,GPAA1,CUX1,NUP98,SMAD7,U
SP4,HDAC6,DYNC1I1,HGS,DERL2,SYTL4,GLS,PAX8,RBPMS,XBP1,C
OG4,NISCH,PAM,AP3S2,UHMK1,ADAM8,RAB35,CD9,RANBP1,DDX39
A,KPNA6,ACTR3,UPF3A,PRKACA,PLK1,NUTF2,DNM1L,UPF1,NPC1,H
ERC2,CNP,VAMP7,CAMK2D,FYTTD1,BBS1,SLC38A2,TPCN2,VTI1A,H
PS4,DISP1,SNCAIP,TIMM23,CPT1B,SEC31A,MDM2,SNAP23,FKBP1A,
TLN2,CREB1,SRP9,DDX58,RPL27,LCP2,PTPRK,SNX13,AP4B1,RHBD
biol
F1,NF1,NUMA1,RPL9,NIPBL,RAB31,CAPN10,PKD2,LMNA,RB1,LTBP4,
ogic
STX16,BLOC1S5,TXNDC5,PAFAH1B1,STARD3,SYTL2,AACS,SYNE1,B
al_p
ICD1,GCC2,NR1H3,FLCN,RPL24,RPL37A,STX2,IQGAP1,PHPT1,SNX1
roce
7,KPNB1,PPP1R10,MEF2A,OXCT1,WASH4P,NECAB3,CACNB1,CLTCL
ss
1,ABCA2,RAB8A,DENND4C,CSK,CDK5RAP2,PTPRC,STX18,CLTB,FL
OT1,GOPC,PAK1,LEPROT,RAB10,SEMA6A,VPS45,ACD,CSF1R,ERC1,
TIMM50,OS9,SRSF10,SMAD4,GRPEL2,C1QTNF3,EZR,RPL4,FLNA,RA
B5A,SUN2,HGSNAT,ATP5A1,GLI3,TMED2,SDCBP2,THOC2,SCFD1,VT
I1B,GAA,SLC25A6,VAMP4,MDFI,CIZ1,STAM2,NCBP2,MLX,VPS51,TGS
1,RAP1B,CANX,RUNX1,LRPPRC,RPLP0,SDAD1,SNX27,KIF13B,RHBD
F2,CRCP,TLN1,NLGN2,PDIA3,LONP2,CSNK1E,ATG3,LMF1,SPCS3,PK
D1,PDPK1,TSG101,KPNA1,CD63,SCAMP1,UBR5,CLASP1,PABPN1
biol FZD6,EIF2B4,CADM1,CKB,IGF1R,PTS,COL2A1,FMR1,LEF1,PAX8,EM
ogic X2,BCL2L11,PAM,CD9,LHX4,SEPT4,CNP,CLN8,JHDM1D,GIGYF2,STK
al_p 4,FGFR1,RAB18,SHARPIN,CREB1,NF1,ZEB1,NIPBL,PKD2,CASP2,MA
2.52
611
859
3
7.
9
8
E
0
3
1.17
821
500
9
8.
1
4
E
0
3
1.33
203
993
8.
1
5
07
41
7
G
O:
00
30
65
8
G
O:
00
05
81
3
G
O:
00
45
33
5
G
O:
00
44
24
9
roce PK8IP3,PAFAH1B1,PTEN,FYN,ALDH1A3,CTNS,SRGAP2,NCOR1,MEF
ss
2A,OXCT1,TCTN1,MYCBP2,PBX3,CSK,CDK5RAP2,PTPRS,CDK6,NR2
C2,GLI3,ENG,EXT1,STK36,WWP1,EPOR,RUNX1,SMARCA4,NCOR2,F
PGS,SETD2,ROBO2,CDK5RAP1,SMAD9,CTTNBP2,ZBTB16,PKD1,FOX
C1,CDK5RAP3,C2CD3,TENM4,GATA2
6
transport vesicle membrane
cell
ular
CPE,HLA-DPB1,SYTL4,HLA-C,HLA_co
DQA1,VAMP7,SEC31A,MCFD2,CLTCL1,HLA-F,CLTB,SEC31B
mpo
nent
2.18
077
835
4
centrosome
cell
ular
_co
mpo
nent
1.48
077
542
6
phagocytic vesicle
cell
ular
RAB34,HLA-C,ADAM8,VAMP7,RAB31,SRGAP2,ITGB5,HLA_co
F,RAB8A,RAB10,ATP6V0A1
mpo
nent
cellular biosynthetic process
biol
ogic
al_p
roce
ss
SYTL4,STARD9,CEP135,MARK4,RANBP1,PRKACA,DHX9,PLK1,SDCC
AG8,TTC19,HERC2,CCDC14,DPF2,TCHP,KIAA0586,ZFYVE26,DIS3L,F
LII,PPP2R3C,GNAI1,PAFAH1B1,PLK2,CEP112,CSK,CDK5RAP2,DDHD
2,FLOT1,WDR35,SMAD4,AK5,HAUS5,DZIP1,YIF1A,TLN1,DYNC1I2,PS
MA1,CLIC4,BNIP2,C2CD3,CLASP1
FZD6,OBFC1,PBX2,KANK2,ACADVL,EIF2B4,GTF3C2,RAI1,IGF1R,PTS
,TNRC6A,SIRT2,MYNN,TRNAU1AP,NOC2L,TARS,RAF1,ZNF131,RSC1
A1,SFSWAP,CDK13,TAZ,SIN3B,CBX5,SUPT5H,SUPT20H,ST3GAL1,P
WP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,SHMT2,EEF2K,PLD1
,VAPB,GPAA1,CUX1,PGS1,NUP98,EED,FMR1,SMPD4,SMAD7,MCF2L,
HDAC6,EHMT1,ZNF496,NARS,LANCL2,PNKP,LEF1,GLS,PAX8,SUPT4
2.26
362
655
2
1.09
660
962
2
E
0
3
8.
1
8
E
0
3
8.
2
0
E
0
3
8.
4
1
E
0
3
8.
4
2
E
0
H1,ZNF83,EMX2,RBPMS,XYLT1,ZSCAN31,XBP1,FDPS,PAM,HSD17B1
2,APITD1,UHMK1,USP47,ADAM8,POLR3E,GABPB1,PCGF6,EEF1A1,L
HX4,CSNK2A1,IGBP1,UPF3A,NOD1,STAT2,PIGS,PLK1,ZNF446,PNPO,
ASNS,PTGES2,UPF1,ZNF621,HDGF,PPP5C,PIGG,PDXK,NPC1,CCNL1
,CHD6,ZC3H12A,SLC11A2,FAM58A,CLN8,TBX18,PIGN,GCDH,LBX2,P
CGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,GIGYF2,WAC,Z
NF142,FUBP3,RARS,ZNF540,ALDH18A1,FGFR1,HSF4,PAIP1,CAPRIN
1,GTF3C1,NADSYN1,ADCY4,CELF1,PAF1,TAB2,SGK1,DPF2,CHKB,N
ADK,IDI1,RNF8,SEC31A,MDM2,PRKCH,PPM1F,ZNF595,TBP,YY1,INO8
0,GPAT2,GMEB2,MCFD2,PFDN5,CREB1,SRP9,FLII,RPRD1A,DDX58,R
PL27,CCNL2,PTPRK,NF1,ZEB1,EIF4B,IFITM3,ASCC2,RGMB,EBF1,RP
L9,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,ADSL,ALG6,ST3GAL4,BRD9,
GCNT2,ZNF837,PKD2,RXRB,LMNA,RSL1D1,MITF,NOL8,RB1,PRMT5,
MZF1,ZFPM2,TP53BP1,RNF168,ZNF865,SENP2,ISYNA1,EDEM2,GPC
PD1,PUM2,STARD3,SUB1,CHMP1A,PDE8A,ZNF558,GALNT2,ZNF263,
ZNF180,BICD1,ZNF276,NR1H3,GARS,GRB10,MRPS7,USP7,PLD6,FLC
N,ZNF605,ZNF410,GMDS,RPL24,UST,MTMR14,RPL37A,SAP30BP,MA
ST2,VPS72,PTEN,ALDH1A3,RNASEK,RUNX2,CSTF1,FBXW7,SMARC
D3,IKBKB,RQCD1,RFX7,NCOR1,PPP1R10,MEF2A,FECH,SETD8,SME
K1,NECAB3,PIAS2,SSBP1,MAPK8,MYCBP2,USP15,DDX41,MAN1A2,P
BX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,OAZ1,IMPDH1,
UBP1,WDR61,EBF4,FARSA,ZNF148,ZNF76,STAG2,SP110,PPA2,ST6G
ALNAC5,PHKG2,NCK2,TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,ER
C1,C3,NFYC,HSD17B4,ELOVL1,FUT4,PIWIL4,SRSF10,SS18,RCOR3,S
MAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,DDAH1,INO80E,DTYMK,RPL
4,MTRR,MBOAT2,ZNF44,CREBZF,ING4,CD276,RBMS1,EIF3M,ZNF687
,NR2C2,FHOD1,DNTTIP2,MRPL49,FLNA,IRF9,MGAT5,ATP5A1,GLI3,T
HNSL2,MAPK12,CCDC59,DCAF6,AK5,B4GALT4,ENG,SIRT7,ZSCAN5A
,TCF12,ARNT,NOX4,ZNF692,EXT1,GAPDH,PHF1,MTRF1L,B3GAT3,ST
K36,WWP1,PHF12,TBCE,MED6,MDFI,CIRBP,ZNF554,CIZ1,RGS2,HINF
P,NCBP2,MAN2A2,LPCAT1,MLX,PDGFRB,TGS1,CDK11A,MAN1B1,GLI
3
S3,ELP6,BDP1,DBF4,CANX,RUNX1,MKNK2,SMARCA4,NAA16,LRPPR
C,RPLP0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3,CHTF8,GSK
3A,SNRPE,POLG,ZNF383,MRPL3,POLR2J3,NCOR2,FPGS,SETD2,PC
YT1A,PIGO,PPAP2A,PDIA3,IGF2,PTGIS,TROVE2,ATXN3,PSTK,PHF21
A,GPHN,PDCD4,SOX13,PGM2,CHD2,STAT6,CARS2,ZNF138,ZNF705A
,NTRK1,TFAM,PHKG1,BRWD1,SMAD9,HBB,LMF1,TGFBR3,ZBTB16,B
AZ2A,SIRT3,UCK1,SPCS3,EIF3I,RRP8,VARS,LARS,PHF19,LMCD1,PK
D1,PDPK1,TSG101,USF1,FOXC1,DDAH2,ACAN,CDK5RAP3,FMOD,AL
G9,PABPC1,PANK3,EYA2,SMARCAD1,CC2D1A,PLA2G16,GATA2,PAB
PN1
G
O:
00
16
24
1
G
O:
00
48
63
5
G
O:
00
06
44
8
regulation of macroautophagy
biol
ogic
al_p SUPT5H,NPC1,TBC1D14,WAC,NRBP2
roce
ss
3.74
239
791
5
negative regulation of muscle organ
development
biol
ogic
al_p SIRT2,BDNF,LUC7L,LEF1,GSK3A
roce
ss
3.74
239
791
5
regulation of translational elongation
biol
ogic
al_p RNF8,SRP9,RNF168,VARS,LARS
roce
ss
3.74
239
791
5
8.
4
6
E
0
3
8.
4
6
E
0
3
8.
4
6
E
0
3
G
O:
00
06
75
3
G
O:
00
03
69
7
G
O:
00
31
17
5
nucleoside phosphate metabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,CMPK2,GBP3,MCF2L,ARHGEF12,ATP6V1D,H6P
D,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,
RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9
,PDE7B,TBC1D2B,DNM1L,UPF1,FDXR,HERC2,CHD6,TBC1D10B,SEP
T4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB18,NADSYN1,PMS1,
biol ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG5,
ogic DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB31,ADSL,PKD2,GALT,GN
al_p AI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,GARS,CYTH2,FLCN,FMO2
roce ,GMDS,ARHGAP9,IDH1,IQGAP1,CTNS,SRGAP2,ATP11B,DDX41,RNF2
ss
13,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,P
SMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC
1D22A,DTYMK,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHG
EF7,ASAP1,REXO2,IDH3B,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,D
HX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LONP2,ACIN1,PS
D3,BNIP2,NTRK1,UCK1,DHX37,RAPGEF6,PANK3,SMARCAD1,DENND
6B
single-stranded DNA binding
mol
ecul
ar_f
unct
ion
neuron projection development
FZD6,CLMN,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,ARHGEF12,
CD72,ITGA9,UHMK1,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VASP,CSN
biol
K2A1,SLC11A2,CNP,FGFR1,CAPRIN1,SSH2,CREB1,NPTN,RGMB,RPS
ogic
6KA5,RB1,MAPK8IP3,BLOC1S5,PAFAH1B1,USP33,NRP1,PTEN,FYN,S
al_p
RGAP2,MEF2A,TCTN1,CACNB1,MYCBP2,RAB8A,COL9A3,PTPRC,FL
roce
OT1,RANBP9,PAK1,NCK2,RAB10,SEMA6A,SEMA4D,ROBO3,EZR,GLI3
ss
,EXT1,TBCE,UNC5B,PTPRD,ITGA5,FARP1,KIF13B,TLN1,ROBO2,CAC
NB3,PMP22,NTRK1,SEPT2,STK24,SSH1,CLASP1
OBFC1,FUBP1,RAD23A,PMS1,SUB1,SSBP1,ACD,SSBP2,RBMS1,ERC
C1,LRPPRC
1.21
141
204
2
8.
4
8
E
0
3
2.25
112
714
2
8.
6
6
E
0
3
1.32
828
771
1
8.
6
8
E
0
3
G
O:
00
10
60
4
G
O:
00
07
41
1
G
O:
00
30
05
4
positive regulation of macromolecule
metabolic process
OBFC1,PBX2,ACADVL,PSMB10,IGF1R,EPHX2,RAF1,SUPT5H,FUBP1,
MMS19,ZFP91,CNTF,VAPB,SMAD7,MCF2L,HDAC6,ZNF496,LEF1,PAX
8,SUPT4H1,PSMB9,RBPMS,XBP1,APITD1,UHMK1,ADAM8,GABPB1,C
SNK2A1,IGBP1,UPF3A,NOD1,PRKACA,ANAPC4,PLK1,ASNS,PTGES2,
HDGF,ZC3H12A,SEPT4,SYMPK,BCLAF1,JHDM1D,TNK2,WAC,STK4,F
UBP3,FGFR1,HSF4,PAIP1,ADCY4,PAF1,TAB2,RNF8,SEC31A,MDM2,R
HBDD1,FKBP1A,PPM1F,TBP,INO80,CREB1,NPTN,DDX58,ZEB1,NUB1,
biol RGMB,EBF1,RPS6KA5,NIPBL,PKD2,RXRB,LMNA,MITF,RB1,MAPK8IP
ogic 3,ZFPM2,TP53BP1,RNF168,SENP2,IL18,TPP1,NR1H3,FLCN,NRP1,PT
al_p EN,RUNX2,IQGAP1,FBXW7,SMARCD3,HERPUD1,IKBKB,PXN,NCOR1,
roce MEF2A,PIAS2,MAPK8,DDX41,TRIM28,CSK,CDK5RAP2,PTPRC,PSMC
ss
6,CDK6,WDR61,ZNF148,PSMC4,SGSM3,PHKG2,PAK1,NCK2,CTSH,T
CF4,SEMA4D,CSF1R,C3,NFYC,SS18,SMAD4,CHURC1,CHURC1FNTB,TGFB1I1,CD276,CDC14B,NR2C2,FHOD1,GLI3,TMED2,DCAF6,E
NG,SIRT7,TCF12,ARNT,NOX4,PHF1,PDIA5,MED6,MDFI,CIRBP,CIZ1,IT
GA5,HINFP,NCBP2,LPCAT1,PDGFRB,GLIS3,CARD14,TNFRSF14,RUN
X1,SMARCA4,NAA16,YIF1A,TLN1,GSK3A,IGF2,PSMA1,STAT6,CSNK1
E,NTRK1,TFAM,TNFRSF10B,SMAD9,ZBTB16,PHF19,PKD1,PDPK1,US
F1,FOXC1,CDK5RAP3,PABPC1,SMARCAD1,GATA2
axon guidance
biol
ogic
al_p
roce
ss
LAMB1,RAF1,COL9A1,BDNF,COL2A1,ARHGEF12,CD72,ITGA9,LHX4,V
ASP,CSNK2A1,FGFR1,CREB1,RGMB,RPS6KA5,MAPK8IP3,USP33,NR
P1,FYN,SRGAP2,CACNB1,MYCBP2,COL9A3,PTPRC,RANBP9,PAK1,N
CK2,SEMA6A,SEMA4D,ROBO3,EZR,GLI3,EXT1,UNC5B,ITGA5,TLN1,R
OBO2,CACNB3,NTRK1,CLASP1
1.47
241
885
2
cell junction
cell
ular
_co
mpo
nent
LPP,CADM1,EPHX2,UTRN,F11R,RSC1A1,DPP4,SMAD7,SIPA1L1,KRIT
1,MINK1,PDLIM5,ACTR3,VASP,SDCCAG8,SYMPK,VAMP7,CAMK2D,J
AM2,TNK2,SIKE1,AFAP1,SNAP23,TLN2,FLII,DDX58,PTPRK,MAGI1,PK
D2,NEXN,ESAM,ARPC2,ADAM15,FLCN,TENC1,STX2,FAP,IQGAP1,PX
N,SRGAP2,TNS1,ITGB5,CSK,CDK5RAP2,PTPRC,TBCD,SGSM3,GOPC
,PARD6G,PAK1,TGFB1I1,EZR,ADD3,VEZT,NOX4,ARHGEF7,ITGA5,RA
1.32
220
419
9
1.18
448
337
1
8.
8
1
E
0
3
8.
8
6
E
0
3
8.
8
6
E
0
P1B,TLN1,NLGN2,TWF1,COL13A1,MYO1E,GPHN,TANC1,PSD3,PMP2
2,CLIC4,LIMS2,LUC7L3,PDPK1,GAK
G
O:
00
70
40
3
NAD+ binding
mol
ecul
ar_f
unct
ion
tau-protein kinase activity
mol
ecul
ar_f
unct
ion
translation regulator activity, nucleic acid
binding
mol
ecul
ar_f
unct
ion
G
O:
00
48
18
5
G
O:
G
O:
00
50
32
1
G
O:
00
90
07
9
3
SIRT2,ALDH1A3,SIRT7,SIRT3
4.50
225
428
3
MARK4,PHKG2,GSK3A,PHKG1
4.50
225
428
3
ZNF540,PAIP1,CELF1,PABPC1
4.50
225
428
3
activin binding
mol
ecul
ar_f
unct
ion
SMAD7,FKBP1A,ENG,TGFBR3
4.50
225
428
3
heart growth
biol
ogic
TBX2,FGFR1,RXRB,MEF2A,GSK3A,DUSP6,TGFBR3,FOXC1,TENM4
2.47
456
9.
1
4
E
0
3
9.
1
4
E
0
3
9.
1
4
E
0
3
9.
1
4
E
0
3
9.
1
00
60
41
9
G
O:
00
16
57
5
al_p
roce
ss
histone deacetylation
G
O:
00
55
08
6
nucleobase-containing small molecule
metabolic process
G
O:
00
phosphatidylglycerol biosynthetic process
biol
ogic
SIRT2,HDAC6,NIPBL,NCOR1,MAPK8,SIRT7,ATXN3,BAZ2A,SMARCAD
al_p
1
roce
ss
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,CMPK2,GBP3,MCF2L,ARHGEF12,ATP6V1D,H6P
D,PNKP,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,
RANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9
,PDE7B,TBC1D2B,DNM1L,UPF1,FDXR,HERC2,CHD6,TBC1D10B,SEP
T4,EFTUD2,CNP,TBC1D14,TNK2,GIT2,MTG1,RAB18,ERH,NADSYN1,P
biol MS1,ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEK
ogic HG5,DDX58,ALDH6A1,SNX13,NF1,RTKN,NPR1,G3BP1,RAB31,ADSL,P
al_p KD2,GALT,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,GARS,CYTH
roce 2,FLCN,FMO2,GMDS,ARHGAP9,IDH1,IQGAP1,CTNS,SRGAP2,ATP11
ss
B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMP
DH1,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB
3,GRPEL2,TBC1D22A,DTYMK,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,
ATP8B2,ARHGEF7,ASAP1,REXO2,IDH3B,RGS2,RAD51B,FARP1,RAP1
B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A,MYO1E,RGL2,CHD2,LO
NP2,ACIN1,PSD3,BNIP2,NTRK1,UCK1,DHX37,RAPGEF6,MTO1,PANK
3,SMARCAD1,DENND6B
biol
ogic TAZ,PLD1,PGS1,PLD6
al_p
515
2
2.47
456
515
2
5
E
0
3
9.
1
5
E
0
3
1.20
562
355
9
9.
2
0
E
0
3
4.49
087
749
9.
2
2
06
65
5
G
O:
00
44
08
5
roce
ss
cellular component biogenesis
G
O:
00
09
89
4
regulation of catabolic process
G
O:
negative regulation of mitotic cell cycle
CRBN,CADM1,IGF1R,RAF1,F11R,SFSWAP,BDNF,TAZ,SART1,RAB34,
MMS19,SHMT2,GPAA1,CLNS1A,NUP98,SMAD7,HDAC6,TTLL3,ARPC4
TTLL3,GLS,BCL2L11,STARD9,COG4,PAM,DDX23,CAPZB,CD9,PDLIM5
,ACTR3,VASP,NOD1,PRKACA,TTC19,DNM1L,RC3H1,PPP5C,ATG4B,B
CLAF1,BBS1,TBC1D14,MTG1,HSF4,DISP1,CELF1,SNCAIP,SF3A2,SH
ARPIN,MDM2,FKBP1A,PRKCH,PPM1F,TLN2,INO80,SSH2,PTPRK,MA
biol
GI1,PIH1D1,ATG12,ADSL,MITF,NOL8,RB1,PRMT5,PUM2,NSA2,ARPC2
ogic
,DDX6,BICD1,PLD6,FLCN,PTEN,IFT172,PXN,SRGAP2,NCOR1,MEF2A,
al_p
TNS1,FECH,ERAL1,WASH4P,VILL,MYLK,RAB8A,TRIM28,TBCD,SKIV2
roce
L2,TSPAN4,COX14,ZNF148,GOPC,RANBP9,WDR35,ATPAF2,PARD6G
ss
,PAK1,NCK2,TCF4,ACD,ACTR2,SRSF10,SMAD4,C1QTNF3,EZR,CENP
T,FHOD1,FLNA,RAB5A,HGSNAT,BCS1L,TMED2,NOX4,STK36,ARHGE
F7,TBCE,CIRBP,NUP85,NUBP1,HAUS5,PTPRD,ITGA5,NCBP2,TGS1,D
ZIP1,CC2D2A,FARP1,RPLP0,SDAD1,KCTD2,TLN1,SNRPE,NLGN2,TW
F1,FTSJ3,AMFR,ROBO2,KCTD17,TFAM,SHPRH,ATG3,HBB,TGFBR3,T
MEM237,LIMS2,CD151,BAZ2A,RRP8,SEPT2,UQCRH,SENP6,PDPK1,S
SH1,FMOD,C2CD3,SMARCAD1
USP10,RAB3GAP2,RALGAPA2,SUPT5H,UBXN1,BCL6,SMAD7,ARHGE
F12,HGS,STARD13,RAD23A,ADAM8,DNAJC10,RANBP1,SIPA1L1,CSN
biol
K2A1,PRKACA,PLK1,TBC1D2B,NPC1,ZC3H12A,TBC1D10B,ATG4B,TB
ogic
C1D14,GIT2,WAC,MDM2,RHBDD1,FAM13A,SNX13,RHBDF1,NF1,NUB
al_p
1,PAFAH1B1,ACAP2,RGS3,ARHGAP9,PTEN,FYN,IQGAP1,FBXW7,SR
roce
GAP2,NCOR1,TBCD,ARHGAP29,SGSM3,PHKG2,SEMA4D,SMAD4,TB
ss
C1D22A,FLNA,TMED2,ARNT,NRBP2,ARHGEF7,ASAP1,RGS2,LPCAT1
,GSK3A,LONP2,CSNK1E,BNIP2,NTRK1,RAPGEF6,PABPC1
biol
BCL6,USP47,PAF1,RB1,CHMP1A,DGKZ,SMARCA4,FOXC1
ogic
8
E
0
3
1.19
515
288
2
9.
4
3
E
0
3
1.33
902
310
7
9.
4
4
E
0
3
2.62
880
9.
5
00
45
93
0
G
O:
00
07
39
9
G
O:
19
01
56
4
al_p
roce
ss
nervous system development
organonitrogen compound metabolic
process
634
FZD6,EIF2B4,CADM1,CKB,CLMN,IGF1R,LAMB1,NPHP3,PTS,RAF1,CO
L9A1,BDNF,COL2A1,CNTF,CUX1,FMR1,ARHGEF12,CD72,LEF1,PAX8,
EMX2,ITGA9,BCL2L11,PAM,MARK4,UHMK1,CD9,SIPA1L1,MINK1,PDLI
M5,ACTR3,LHX4,VASP,CSNK2A1,JAG2,CHD6,SEPT4,SLC11A2,LSAM
P,CNP,CLN8,JHDM1D,GIGYF2,STK4,FGFR1,RAB18,CAPRIN1,SHARPI
N,PRKCH,SSH2,CREB1,NPTN,DFNA5,NF1,ZEB1,RGMB,RPS6KA5,NIP
biol BL,PKD2,CASP2,ITGA3,RB1,MAPK8IP3,BLOC1S5,PAFAH1B1,MTCH1,
1.19
ogic TPP1,USP33,HEXA,NRP1,PTEN,FYN,ALDH1A3,SMARCD3,IFT172,CT
397
al_p NS,SRGAP2,NCOR1,MEF2A,OXCT1,TCTN1,CACNB1,MYCBP2,PBX3,
257
roce RAB8A,CSK,CDK5RAP2,COL9A3,PTPRS,PTPRC,CDK6,FLOT1,RANBP
7
ss
9,PAK1,NCK2,RAB10,SEMA6A,TCF4,SEMA4D,ROBO3,SMAD4,NAV1,E
ZR,NR2C2,RAB5A,GLI3,TMED2,SDCBP2,ENG,TCF12,EXT1,NRBP2,ST
K36,SDHA,WWP1,ARHGEF7,TBCE,UNC5B,PTPRD,ITGA5,EPOR,FAR
P1,RUNX1,SMARCA4,KIF13B,TLN1,FGF14,GSK3A,NLGN2,NCOR2,FP
GS,SETD2,ATXN3,PSD3,ROBO2,CACNB3,PMP22,CDK5RAP1,BNIP2,
NTRK1,SMAD9,CTTNBP2,ZBTB16,SEPT2,PKD1,FOXC1,STK24,SEMA
4B,SSH1,CDK5RAP3,C2CD3,WNK1,CLASP1,TENM4,GATA2
CRBN,RAB3GAP2,DHX34,EIF2B4,PSMB10,CKB,PTS,MYO1D,RALGAP
A2,TARS,RAF1,SEPT5,ATP2B1,RAB34,ST3GAL1,BCL6,CMPK2,ENOS
F1,GBP3,SHMT2,VAPB,AMT,SMPD4,MCF2L,ARHGEF12,ATP6V1D,NA
biol
RS,H6PD,GLS,PAX8,PSMB9,ARHGEF25,RGL4,XYLT1,STARD13,PAM, 1.16
ogic
ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,KRIT1,SKI 075
al_p
V2L,MINK1,RHOF,EEF1A1,DHX9,PNPO,PDE7B,ASNS,TBC1D2B,DNM
378
roce
1L,UPF1,FDXR,PDXK,HERC2,CHD6,TBC1D10B,SEPT4,SLC11A2,EFT
2
ss
UD2,CLN8,GCDH,DNPEP,TBC1D14,TNK2,GIT2,MTG1,RARS,ALDH18A
1,RAB18,ERH,NADSYN1,PMS1,ADCY4,SNCAIP,PDE4D,PLEKHG4,CH
KB,NADK,FKBP1A,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,ALDH6
1
E
0
3
9.
5
3
E
0
3
9.
6
0
E
0
3
G
O:
00
23
05
1
regulation of signaling
A1,SNX13,NF1,RTKN,NPR1,G3BP1,RAB31,ADSL,ST3GAL4,GCNT2,PK
D2,GNAI1,PAFAH1B1,TPP1,PDE8A,DDX6,ACAP2,RGS3,GARS,CYTH2
,HEXA,FLCN,FMO2,ARHGAP9,UST,IDH1,IQGAP1,CTNS,SRGAP2,ATP
11B,FECH,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,ITPA,OAZ1,PS
MC6,TBCD,IMPDH1,SKIV2L2,FARSA,PSMC4,ARHGAP29,SGSM3,GOP
C,PPA2,ST6GALNAC5,RHEB,CTSH,SEMA4D,GNB3,P4HB,ELOVL1,GR
PEL2,TBC1D22A,DDAH1,DTYMK,MTRR,MBOAT2,DLST,RAB5A,HGSN
AT,ATP5A1,TMED2,THNSL2,RASGRF2,AK5,GUSB,B4GALT4,NOX4,EX
T1,B3GAT3,ATP8B2,ARHGEF7,ASAP1,IDH3B,RGS2,LPCAT1,PDGFRB
,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A,F
PGS,PCYT1A,PPAP2A,MYO1E,GPHN,RGL2,CHD2,LONP2,PSMA1,CA
RS2,ACIN1,PSD3,CTBS,BNIP2,NTRK1,UCK1,SPCS3,VARS,LARS,DHX
37,FOXC1,DDAH2,ACAN,RAPGEF6,FMOD,MTO1,PANK3,DENND6B,P
LA2G16
FZD6,CDK14,KANK2,IGF1R,NPHP3,RALGAPA2,RAF1,BDNF,BCL6,PT
PN22,ZFP91,CNTF,SMAD7,MCF2L,HDAC6,GLG1,ARHGEF12,VRK2,H
GS,LANCL2,SYTL4,LEF1,PAX8,ARHGEF25,BCL2L11,RBPMS,STARD1
3,XBP1,NISCH,ADAM8,SIPA1L1,MINK1,RHOF,PTPN6,CSNK2A1,IGBP
1,NOD1,PRKACA,STAT2,TBC1D2B,DNM1L,RC3H1,PPP5C,SHISA5,RH
OBTB1,TBC1D10B,SEPT4,MIB2,TBX18,BCLAF1,TBC1D14,USP20,GIT2
,STK4,FGFR1,DISP1,SNCAIP,TAB2,PLEKHG4,SHARPIN,MDM2,FKBP1
biol
A,PRKCH,FAM13A,PFDN5,CREB1,NPTN,PLEKHG5,SNX13,RHBDF1,N
ogic
F1,ZEB1,G3BP1,CAPN10,PKD2,RB1,LTBP4,MAPK8IP3,PAFAH1B1,SE
al_p
NP2,MTCH1,AACS,ACAP2,USP33,BICD1,RGS3,NR1H3,CYTH2,GRB10
roce
,PLK2,FLCN,ARHGAP9,PTEN,FYN,RUNX2,IQGAP1,FBXW7,PHPT1,IKB
ss
KB,RQCD1,PXN,SRGAP2,LTBR,NCOR1,MEF2A,OXCT1,SETD8,TCTN1
,PIAS2,MAPK8,SH3BP2,USP15,RAB8A,MAP4K4,CSK,PTPRC,RNF146,
FLOT1,ARHGAP29,SGSM3,AAK1,PAK1,EVC,NCK2,LEPROT,RHEB,SE
MA4D,CSF1R,DGKZ,C3,SMAD4,TBC1D22A,C1QTNF3,TGFB1I1,GOLP
H3,LRPAP1,APOL3,FLNA,GLI3,RASGRF2,EPS15L1,EPN1,ENG,ARNT,
NOX4,BICC1,SLC25A6,STK36,ARHGEF7,ASAP1,UNC5B,MDFI,ITGA5,
RGS2,STAM2,PDGFRB,CARD14,FARP1,RAP1B,RUNX1,SMARCA4,AD
1.17
018
728
9
9.
6
0
E
0
3
G
O:
00
09
11
6
G
O:
00
10
62
9
G
O:
00
05
nucleoside metabolic process
negative regulation of gene expression
cell-cell junction
RBK2,GSK3A,ANKRD6,NLGN2,IGF2,PTGIS,PDCD4,SNX14,RGL2,CRIP
AK,PSD3,CSNK1E,BNIP2,NTRK1,SPRED1,TNFRSF10B,DUSP6,TGFB
R3,TMEM237,SPCS3,LMCD1,PDPK1,RAPGEF6,C2CD3,UBR5,CC2D1A
,TENM4,GATA2
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
biol
AB18,ERH,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG
ogic
5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,ADSL,GNAI1,PAFAH1B1,D
al_p
DX6,ACAP2,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,A
roce
TP11B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,PSMC6,TBCD,IMP
ss
DH1,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB
3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2
,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,D
OCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK
1,UCK1,DHX37,RAPGEF6,MTO1,PANK3,DENND6B
KANK2,TNRC6A,SIRT2,NOC2L,SIN3B,CBX5,SUPT5H,BCL6,TBX2,CUX
1,EED,SMAD7,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,USP4
7,PCGF6,IGBP1,PLK1,HDGF,ZC3H12A,TBX18,DR1,BCLAF1,ZNF540,F
biol
GFR1,HSF4,CELF1,PAF1,MDM2,PPM1F,YY1,PFDN5,CREB1,PTPRK,Z
ogic
EB1,RPS6KA5,NIPBL,RB1,PRMT5,ZFPM2,CHMP1A,ZNF263,NR1H3,FL
al_p
CN,VPS72,FYN,RUNX2,NCOR1,MEF2A,SETD8,UPK3B,TRIM28,UBP1,
roce
ZNF148,TCF4,SEMA4D,PIWIL4,SMAD4,C1QTNF3,CREBZF,ING4,GLI3,
ss
ENG,SIRT7,WWP1,PHF12,MDFI,HINFP,NCBP2,MLX,GLIS3,SMARCA4,
PER3,NCOR2,PHF21A,PDCD4,STAT6,ZBTB16,BAZ2A,RRP8,LMCD1,T
SG101,PABPC1,CC2D1A,GATA2
cell CADM1,F11R,DPP4,SMAD7,KRIT1,SDCCAG8,SYMPK,CAMK2D,JAM2,
ular TLN2,DDX58,PTPRK,MAGI1,PKD2,ESAM,FLCN,STX2,IQGAP1,CSK,TB
_co CD,SGSM3,PARD6G,PAK1,ADD3,ITGA5,RAP1B,TLN1,TWF1,COL13A1
mpo ,MYO1E,PMP22,CLIC4
1.23
047
262
7
9.
6
8
E
0
3
1.27
560
031
1
9.
7
4
E
0
3
1.53
878
518
5
9.
9
5
E
91
1
G
O:
19
01
56
5
G
O:
00
02
76
8
G
O:
00
35
55
6
nent
0
3
organonitrogen compound catabolic
process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,ENOSF1,GBP3,AMT,SMPD4,MCF2L,ARHGEF12,ATP6V1
D,GLS,ARHGEF25,RGL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,R
ANBP1,SIPA1L1,DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,
PDE7B,TBC1D2B,DNM1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFT
UD2,GCDH,TBC1D14,TNK2,GIT2,MTG1,RAB18,PMS1,PDE4D,PLEKHG
biol
4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,ALDH6A1,SNX13,NF1,R
ogic
TKN,G3BP1,RAB31,GNAI1,PAFAH1B1,TPP1,PDE8A,DDX6,ACAP2,RG
al_p
S3,CYTH2,HEXA,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213
roce
,ABCA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,SKIV2L2,PSMC4,ARH
ss
GAP29,SGSM3,GOPC,RHEB,CTSH,SEMA4D,GNB3,GRPEL2,TBC1D22
A,DDAH1,DLST,RAB5A,HGSNAT,ATP5A1,TMED2,THNSL2,RASGRF2,
GUSB,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMA
RCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,ACIN1,PS
D3,CTBS,BNIP2,NTRK1,DHX37,DDAH2,ACAN,RAPGEF6,FMOD,DENN
D6B
immune response-regulating cell surface
receptor signaling pathway
biol
ogic BTN3A1,HLA-DPB1,PTPN22,HLAal_p DQA1,PTPN6,VASP,RC3H1,TAB2,PRKCH,LCP2,PTEN,FYN,PHPT1,IKB
roce KB,MEF2A,CSK,PTPRC,PAK1,CACNB3,PDPK1
ss
1.74
969
253
2
intracellular signal transduction
biol
ogic
al_p
roce
ss
USP10,PSMB10,IGF1R,RALGAPA2,RAF1,PLCD1,SART1,RAB34,BCL6,
ZFP91,CNTF,PLD1,SMAD7,MCF2L,ARHGEF12,VRK2,HGS,DGKA,PSM
B9,ARHGEF25,RGL4,BCL2L11,STARD13,NISCH,ADAM8,DNAJC10,RA
B35,SIPA1L1,KRIT1,MINK1,RHOF,PTPN6,IGBP1,NOD1,PRKACA,STAT
2,TBC1D2B,DNM1L,PPP5C,SHISA5,RHOBTB1,TBC1D10B,SEPT4,MIB
2,RAB24,BCLAF1,CAMK2D,PLCB4,TBC1D14,TNK2,GIT2,STK4,FGFR1,
1.17
586
585
4
1.21
543
527
9.
9
8
E
0
3
1.
0
1
E
0
2
1.
0
2
E
0
RAB18,ADCY4,TAB2,PLEKHG4,SHARPIN,MDM2,FKBP1A,PRKCH,PP
M1F,FAM13A,CREB1,RALGPS2,PLEKHG5,DDX58,NF1,SPSB3,RTKN,
NPR1,RPS6KA5,G3BP1,RAB31,PKD2,CASP2,RB1,MAPK8IP3,PAFAH1
B1,IL18,PDE8A,STK38L,ACAP2,SH3BP5,RGS3,CYTH2,PLK2,FLCN,CU
L4A,TENC1,ARHGAP9,PTEN,FYN,SRPK1,IQGAP1,FBXW7,IKBKB,PXN
,SRGAP2,LTBR,NCOR1,MEF2A,TNS1,SETD8,MAPK8,RAB8A,MAP4K4,
CSK,PTPRC,PSMC6,FLOT1,PSMC4,ARHGAP29,SGSM3,PAK1,LEPRO
T,RAB10,RHEB,CTSH,SEMA4D,CSF1R,ERC1,DGKZ,SS18,TBC1D22A,
C1QTNF3,DDAH1,ASB8,GOLPH3,TANK,ING4,APOL3,FLNA,RAB5A,SD
CBP2,MAPK12,RASGRF2,NOX4,STK36,ARHGEF7,DEF8,ASAP1,MDFI,
RGS2,PDGFRB,CARD14,DIABLO,FARP1,RAP1B,MKNK2,FGF14,DOCK
8,GSK3A,POLR2J3,IGF2,MOB1A,PDCD4,ARL15,RGL2,RABL3,PSMA1,
PSD3,BNIP2,NTRK1,SPRED1,TNFRSF10B,DUSP6,TGFBR3,RRP8,LM
CD1,PKD1,PDPK1,DDAH2,STK24,RAPGEF6,WNK1,CC2D1A
G
O:
00
06
98
6
G
O:
00
09
16
4
response to unfolded protein
biol
ogic
ACADVL,VAPB,DERL2,XBP1,ASNS,HDGF,SEC31A,RHBDD1,SERPINH
al_p
1,LMNA,EDEM2,TPP1,HERPUD1,PDIA5,YIF1A,TLN1,GSK3A,AMFR
roce
ss
nucleoside catabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
biol KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ogic ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
al_p AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
roce X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
ss
CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
DENND4C,MAP4K4,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM
3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,T
MED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RA
2
1.80
975
660
4
1.
0
2
E
0
2
1.24
150
538
3
1.
0
2
E
0
2
G
O:
00
44
43
1
G
O:
00
05
65
2
G
O:
00
05
67
7
G
O:
00
04
22
1
Golgi apparatus part
P1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
PPIL2,HLA-DPB1,ST3GAL1,PLD1,CUX1,SMPD4,GLG1,IL15RA,HLAC,XYLT1,COG4,HLAcell DQA1,RNF24,ACTR3,LMAN2,PTGES2,VTI1A,MMP16,QSOX1,RHBDF1,
ular ST3GAL4,GCNT2,GOLGA8B,GOLGA8A,MAPK8IP3,STX16,GALNT2,US
_co T,NECAB3,CLSTN2,CLTCL1,MAN1A2,HLAmpo F,SLC35D2,STX18,NSFL1C,CLTB,GOPC,ST6GALNAC5,LEPROT,VPS4
nent 5,ERC1,FUT4,TMED3,SLC35A4,GOLPH3,MGAT5,TMED2,B4GALT4,SC
FD1,PCSK7,EXT1,B3GAT3,VAMP4,MAN2A2,LPCAT1,VPS51,YIF1A,CO
RO7,SLC9A8,ACAN,FMOD,GORASP1
1.34
182
595
1
nuclear lamina
cell
ular
_co LMNA,LMNB1,NARF
mpo
nent
5.99
714
047
4
chromatin silencing complex
cell
ular
_co SIRT2,BAZ2A,RRP8
mpo
nent
5.99
714
047
4
ubiquitin thiolesterase activity
mol
ecul
ar_f
unct
ion
2.04
171
996
6
USP10,USP4,USP47,USP20,USP24,USP3,USP33,PAN2,USP7,USP15,
USP54,USP40,ATXN3
1.
0
2
E
0
2
1.
0
2
E
0
2
1.
0
2
E
0
2
1.
0
4
E
0
2
G
O:
00
31
30
1
G
O:
00
32
58
0
G
O:
00
51
34
5
G
O:
00
48
58
5
integral to organelle membrane
cell
ular
_co
mpo
nent
Golgi cisterna membrane
cell
ular
ST3GAL1,ST3GAL4,GOLGA8B,GOLGA8A,GALNT2,FUT4,TMED3,GOL
_co
PH3,TMED2,B4GALT4,SCFD1
mpo
nent
positive regulation of hydrolase activity
negative regulation of response to stimulus
HLA-DPB1,ST3GAL1,GPAA1,CUX1,DERL2,HLA-C,HLADQA1,MARCH6,PIGS,TIMM23,RHBDD1,QSOX1,EMC3,ST3GAL4,PKD2
,GALNT2,HLAF,TMEM66,EMC4,ST6GALNAC5,ELOVL1,PCSK7,EXT1,CANX,AMFR
RAB3GAP2,ACADVL,RALGAPA2,NLRP1,VAPB,ARHGEF12,BCL2L13,B
CL2L11,STARD13,XBP1,DNAJC10,RANBP1,SIPA1L1,NOD1,PRKACA,
biol
ASNS,TBC1D2B,HDGF,TBC1D10B,SLC11A2,TBC1D14,GIT2,FGFR1,A
ogic
DCY4,SEC31A,PPM1F,FAM13A,CREB1,SNX13,NF1,LMNA,MTCH1,TP
al_p
P1,ACAP2,RGS3,NR1H3,ARHGAP9,IQGAP1,HERPUD1,SRGAP2,MEF
roce
2A,SSBP1,MAPK8,TBCD,ARHGAP29,SGSM3,CTSH,SEMA4D,TBC1D2
ss
2A,ARHGEF7,PDIA5,ASAP1,RGS2,PDGFRB,DIABLO,YIF1A,TLN1,GSK
3A,BNIP2,NTRK1,TNFRSF10B,LMF1
FZD6,KANK2,IGF1R,NPHP3,BCL6,PTPN22,SMAD7,GLG1,ARHGEF12,
HGS,LEF1,PTPN6,IGBP1,RC3H1,NPC1,TBX18,STK4,SHARPIN,MDM2,
biol PFDN5,SNX13,NF1,G3BP1,RB1,PAFAH1B1,BICD1,RGS3,NR1H3,GRB
ogic 10,FLCN,NRP1,PTEN,FYN,RUNX2,FBXW7,PHPT1,RQCD1,NCOR1,PIA
al_p S2,USP15,CSK,PTPRC,CDK6,LEPROT,DGKZ,C1QTNF3,TGFB1I1,CD2
roce 76,LRPAP1,GLI3,EPS15L1,EPN1,ENG,BICC1,NRBP2,ARHGEF7,UNC5
ss
B,MDFI,RGS2,STAM2,SMARCA4,ADRBK2,GSK3A,ANKRD6,PTGIS,PD
CD4,SNX14,CRIPAK,PSMA1,STAT6,ROBO2,CSNK1E,SPRED1,DUSP6
,TGFBR3,PDPK1,UBR5,GATA2
1.63
473
455
3
2.19
895
150
7
1.
0
4
E
0
2
1.
0
4
E
0
2
1.34
293
121
3
1.
0
4
E
0
2
1.29
576
490
1
1.
0
5
E
0
2
G
O:
00
71
70
2
G
O:
00
19
00
3
G
O:
00
51
25
organic substance transport
RAB3GAP2,CADM1,BTN3A1,NLRP1,SLC16A3,BDNF,CCDC91,RAB34,
SLC38A9,BCL6,NUP98,FMR1,HDAC6,ATP6V1D,HGS,DERL2,SYTL4,G
LS,PAX8,RBPMS,XBP1,COG4,NISCH,PAM,AP3S2,UHMK1,ADAM8,RA
B35,DDX39A,KPNA6,UPF3A,PRKACA,VPS52,LMAN2,NUTF2,DNM1L,U
PF1,NPC1,HERC2,NUP210,RAB24,ATG4B,SLC26A6,CLN8,VAMP7,FY
TTD1,SLC16A1,BBS1,SLC38A2,VTI1A,HPS4,RAB18,DISP1,SLC4A2,TI
MM23,CPT1B,SEC31A,MDM2,SNAP23,SFT2D2,MCFD2,SRP9,DDX58,
RPL27,LCP2,SNX13,AP4B1,RHBDF1,SNX21,NF1,RPL9,RAB31,CAPN1
biol
0,PKD2,LMNA,LTBP4,STX16,PAFAH1B1,MFSD10,SENP2,STARD3,SY
ogic
TL2,CHMP1A,AACS,GCC2,NR1H3,GRB10,RPL24,RPL37A,STX2,IQGA
al_p
P1,PHPT1,CTNS,SNX17,KPNB1,NCOR1,ATP11B,PPP1R10,OXCT1,NE
roce
CAB3,CACNB1,CLTCL1,OSBPL3,ABCA2,RAB8A,SLC35D2,DENND4C,
ss
CSK,STX18,NUP37,CLTB,GOPC,RAB10,VPS45,ACD,CSF1R,ATP6V0A
1,ERC1,TIMM50,OS9,C3,SRSF10,TMED3,SMAD4,GRPEL2,C1QTNF3,
SLC35A4,SLC4A4,RPL4,SLC23A2,APOL3,FLNA,RAB5A,CA5B,GLI3,TM
ED2,THOC2,MCOLN1,SCFD1,VTI1B,SLC25A6,ATP8B2,VAMP4,MDFI,N
UP85,SLCO2B1,STAM2,NCBP2,VPS51,RAP1B,CANX,RUNX1,LRPPRC
,YIF1A,RPLP0,SDAD1,SNX27,KIF13B,RHBDF2,GSK3A,ATG4A,PDIA3,
ATG16L2,SLC38A5,SNX14,LONP2,ATG3,HBB,LMF1,SEC31B,SPCS3,S
EPT2,PKD1,TSG101,KPNA1,SCAMP1,UBR5,GORASP1,PABPN1
GDP binding
mol
ecul
ar_f
unct
ion
EIF2B4,MCF2L,ARHGEF12,ARHGEF25,RGL4,RAB35,RANBP1,HERC2,
RAB18,PLEKHG4,RALGPS2,PLEKHG5,RAB31,CYTH2,RAB8A,DENND
4C,RAB10,RHEB,RAB5A,RASGRF2,ARHGEF7,FARP1,RAP1B,DOCK8,
RGL2,PSD3,RAPGEF6,DENND6B
1.58
238
225
9
negative regulation of RNA metabolic
process
biol
ogic
al_p
roce
ss
KANK2,SIRT2,NOC2L,SFSWAP,SIN3B,CBX5,SUPT5H,BCL6,TBX2,CU
X1,EED,SMAD7,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,USP
47,PCGF6,IGBP1,PLK1,HDGF,TBX18,DR1,BCLAF1,ZNF540,FGFR1,HS
F4,PAF1,MDM2,PPM1F,YY1,PFDN5,CREB1,PTPRK,ZEB1,IFITM3,RPS
6KA5,NIPBL,RB1,PRMT5,ZFPM2,CHMP1A,ZNF263,NR1H3,FLCN,VPS7
1.28
165
473
3
1.17
352
857
2
1.
0
5
E
0
2
1.
0
5
E
0
2
1.
0
6
E
-
3
G
O:
00
70
64
6
G
O:
00
71
01
3
2,RUNX2,NCOR1,MEF2A,SETD8,TRIM28,UBP1,ZNF148,TCF4,SEMA4
D,SRSF10,SMAD4,CREBZF,ING4,GLI3,ENG,SIRT7,WWP1,PHF12,MDF
I,HINFP,MLX,GLIS3,SMARCA4,PER3,NCOR2,PHF21A,PDCD4,STAT6,
ZBTB16,BAZ2A,RRP8,LMCD1,TSG101,PABPC1,CC2D1A,GATA2
0
2
protein modification by small protein
removal
biol
ogic
USP10,USP4,USP47,USP20,COPS7B,USP3,SENP2,USP33,USP7,USP
al_p
15,ATXN3,SENP6
roce
ss
2.09
963
103
8
catalytic step 2 spliceosome
cell
ular
SART1,DDX23,EFTUD2,SF3A2,HNRNPA3,DDX41,SRRM2,SKIV2L2,PR
_co
PF8,SNRPE,PRPF4B,PABPC1
mpo
nent
2.09
899
916
6
G
O:
00
48
69
9
generation of neurons
G
O:
00
kinase binding
FZD6,CLMN,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,CNTF,CUX1,
ARHGEF12,CD72,LEF1,EMX2,ITGA9,UHMK1,SIPA1L1,MINK1,PDLIM5,
ACTR3,LHX4,VASP,CSNK2A1,JAG2,SLC11A2,CNP,CLN8,GIGYF2,FGF
biol R1,CAPRIN1,PRKCH,SSH2,CREB1,NPTN,DFNA5,NF1,ZEB1,RGMB,RP
ogic S6KA5,ITGA3,RB1,MAPK8IP3,BLOC1S5,PAFAH1B1,MTCH1,USP33,HE
al_p XA,NRP1,PTEN,FYN,SMARCD3,SRGAP2,MEF2A,TCTN1,CACNB1,MY
roce CBP2,PBX3,RAB8A,CDK5RAP2,COL9A3,PTPRC,CDK6,FLOT1,RANBP
ss
9,PAK1,NCK2,RAB10,SEMA6A,TCF4,SEMA4D,ROBO3,SMAD4,NAV1,E
ZR,GLI3,TCF12,EXT1,NRBP2,TBCE,UNC5B,PTPRD,ITGA5,FARP1,RU
NX1,KIF13B,TLN1,PSD3,ROBO2,CACNB3,PMP22,CDK5RAP1,BNIP2,N
TRK1,SEPT2,STK24,SSH1,CDK5RAP3,WNK1,CLASP1,TENM4,GATA2
mol UTRN,RAF1,PTPN22,PAM,PDLIM5,PTPN6,EEF1A1,IGBP1,PRKACA,PL
ecul K1,CCNL1,FAM58A,TBC1D14,STK11IP,TPCN2,CCNL2,PTPRK,NPR1,R
ar_f B1,MAPK8IP3,PTEN,IQGAP1,IKBKB,PXN,MEF2A,PARN,PRKRIP1,RAB
1.
0
9
E
0
2
1.
1
0
E
0
2
1.24
838
154
3
1.
1
0
E
0
2
1.43
051
921
1.
1
0
19
90
0
G
O:
00
03
77
9
G
O:
00
34
32
9
G
O:
00
00
78
5
G
O:
00
34
71
3
unct
ion
8A,CDK5RAP2,PTPRC,PAK1,RHEB,FLNA,ARHGEF7,RAD54L2,KIF13B,
GSK3A,CDK5RAP1,SPRED1,PKD1,PDPK1,USF1,CDK5RAP3
8
actin binding
mol
ecul
ar_f
unct
ion
CLMN,MYO1D,UTRN,HDAC6,CAPZB,PDLIM5,ACTR3,VASP,MIB2,AFA
P1,TLN2,INO80,SSH2,FLII,LIMCH1,TPM4,MED28,NEXN,ARPC2,SYNE
1,STK38L,DAAM1,TNS1,WASH4P,VILL,MYLK,TRPM7,ACTR2,EZR,FH
OD1,FLNA,ADD3,MYO7B,LRPPRC,TLN1,TWF1,MYO1E,CORO7,SSH1
1.45
917
936
6
cell junction assembly
biol
ogic CADM1,F11R,SMAD7,CD9,VASP,PRKACA,PRKCH,PPM1F,TLN2,PTPR
al_p K,FLCN,PTEN,PXN,TNS1,TBCD,PARD6G,FLNA,ITGA5,TLN1,LIMS2,CD
roce 151,PDPK1
ss
1.68
407
906
2
chromatin
cell
ular
_co
mpo
nent
CBX5,EED,CSNK2A1,UPF1,TBP,YY1,INO80,CREB1,RB1,USP3,NR1H3
,RUNX2,SMARCD3,NCOR1,PPP1R10,MEF2A,TRIM28,WDR61,STAG2,
HMGN2,INO80E,SIRT7,PHF12,NCAPD3,SMARCA4,NCOR2,MAU2,STA
T6,SHPRH,BAZ2A,RRP8,FOXC1,SMARCAD1
1.51
403
218
5
type I transforming growth factor beta
receptor binding
mol
ecul
ar_f
unct
ion
SMAD7,FKBP1A,ENG
5.78
861
265
E
0
2
1.
1
1
E
0
2
1.
1
1
E
0
2
1.
1
3
E
0
2
1.
1
3
E
0
2
G
O:
00
04
17
6
ATP-dependent peptidase activity
mol
ecul
ar_f
unct
ion
spliceosomal complex
cell
ular SART1,RBM17,SNRNP70,DDX23,SUGP1,UPF1,EFTUD2,PRPF3,WAC,
_co SF3A2,HNRNPA3,DDX41,SRRM2,SKIV2L2,PRPF8,RHEB,SNRPE,PRP
mpo F4B,PABPC1
nent
1.76
074
985
2
positive regulation of mitotic
metaphase/anaphase transition
biol
ogic
al_p PLK1,RB1,PTEN
roce
ss
5.77
398
535
4
G
O:
00
60
31
8
definitive erythrocyte differentiation
biol
ogic
al_p NCOR1,SMARCA4,TGFBR3
roce
ss
5.77
398
535
4
G
O:
00
50
regulation of B cell receptor signaling
pathway
biol
ogic
PTPN22,PRKCH,PTPRC
al_p
roce
5.77
398
535
4
G
O:
00
05
68
1
G
O:
00
45
84
2
CRBN,LONRF3,LONP2
5.78
861
265
1.
1
3
E
0
2
1.
1
3
E
0
2
1.
1
4
E
0
2
1.
1
4
E
0
2
1.
1
4
E
85
5
G
O:
00
51
48
8
G
O:
00
09
41
5
G
O:
00
72
23
5
G
O:
00
09
18
6
ss
activation of anaphase-promoting complex
activity
biol
ogic
al_p PLK1,PTEN,CDC14B
roce
ss
5.77
398
535
4
response to water stimulus
biol
ogic
al_p CD9,PKD2,NTRK1
roce
ss
5.77
398
535
4
metanephric distal tubule development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
5.77
398
535
4
deoxyribonucleoside diphosphate metabolic
process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
5.77
398
535
4
0
2
1.
1
4
E
0
2
1.
1
4
E
0
2
1.
1
4
E
0
2
1.
1
4
E
0
2
G
O:
19
01
65
8
G
O:
00
30
18
2
G
O:
00
01
93
2
glycosyl compound catabolic process
neuron differentiation
regulation of protein phosphorylation
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
biol ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
ogic AB18,PMS1,PLEKHG4,FAM13A,INO80,RALGPS2,PLEKHG5,DDX58,SN
al_p X13,NF1,RTKN,G3BP1,RAB31,GNAI1,PAFAH1B1,DDX6,ACAP2,RGS3,
roce CYTH2,ARHGAP9,IQGAP1,SRGAP2,ATP11B,DDX41,RNF213,ABCA2,
ss
DENND4C,MAP4K4,PSMC6,TBCD,SKIV2L2,PSMC4,ARHGAP29,SGSM
3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,T
MED2,RASGRF2,ATP8B2,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RA
P1B,SMARCA4,DHX40,DOCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,A
CIN1,PSD3,BNIP2,NTRK1,DHX37,RAPGEF6,DENND6B
FZD6,CLMN,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,CNTF,CUX1,
ARHGEF12,CD72,LEF1,EMX2,ITGA9,UHMK1,SIPA1L1,MINK1,PDLIM5,
ACTR3,LHX4,VASP,CSNK2A1,JAG2,SLC11A2,CNP,CLN8,GIGYF2,FGF
biol R1,CAPRIN1,SSH2,CREB1,NPTN,DFNA5,ZEB1,RGMB,RPS6KA5,RB1,
ogic MAPK8IP3,BLOC1S5,PAFAH1B1,MTCH1,USP33,HEXA,NRP1,PTEN,FY
al_p N,SRGAP2,MEF2A,TCTN1,CACNB1,MYCBP2,PBX3,RAB8A,CDK5RAP
roce 2,COL9A3,PTPRC,FLOT1,RANBP9,PAK1,NCK2,RAB10,SEMA6A,TCF4,
ss
SEMA4D,ROBO3,SMAD4,EZR,GLI3,TCF12,EXT1,NRBP2,TBCE,UNC5B
,PTPRD,ITGA5,FARP1,RUNX1,KIF13B,TLN1,PSD3,ROBO2,CACNB3,P
MP22,CDK5RAP1,BNIP2,NTRK1,SEPT2,STK24,SSH1,CDK5RAP3,WN
K1,CLASP1,GATA2
ACADVL,IGF1R,RAF1,ZFP91,CNTF,EEF2K,VAPB,SMAD7,RBPMS,XBP
1,ADAM8,DNAJC10,PTPN6,NOD1,PRKACA,PLK1,ASNS,HDGF,CCNL1,
biol
FAM58A,TNK2,STK4,FGFR1,ADCY4,TAB2,SEC31A,PPM1F,NPTN,CCN
ogic
L2,NF1,RPS6KA5,PKD2,LMNA,RB1,MAPK8IP3,SENP2,TPP1,SH3BP5,
al_p
RGS3,FLCN,NRP1,PTEN,IQGAP1,FBXW7,HERPUD1,PXN,FECH,PRKR
roce
IP1,CSK,PTPRC,PAK1,NCK2,SEMA4D,CSF1R,C3,SMAD4,AK5,ENG,N
ss
OX4,PDIA5,MDFI,ITGA5,RGS2,PDGFRB,CARD14,TNFRSF14,YIF1A,TL
N1,GSK3A,TWF1,IGF2,PDCD4,CRIPAK,CDK5RAP1,NTRK1,SPRED1,T
1.23
623
135
9
1.
1
5
E
0
2
1.25
762
408
6
1.
1
6
E
0
2
1.28
013
425
8
1.
1
8
E
0
2
NFRSF10B,DUSP6,PKD1,PDPK1,CDK5RAP3,WNK1
G
O:
00
10
46
8
regulation of gene expression
FZD6,PBX2,KANK2,EIF2B4,RAI1,TNRC6A,SIRT2,EPHX2,MYNN,TRNA
U1AP,NOC2L,ZNF131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,COL2A1
,SUPT5H,BCL6,FUBP1,ZNF783,TBX2,MMS19,CUX1,EED,FMR1,SMAD
7,MCF2L,USP4,HDAC6,GLG1,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SU
PT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PAM,SNRNP70,UHMK1,
USP47,ADAM8,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3
A,NOD1,STAT2,DHX9,PLK1,ZNF446,PTGES2,UPF1,ZNF621,HDGF,RC
3H1,CCNL1,CHD6,ZC3H12A,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF
1,ZNF721,ZNF397,JHDM1D,ZNF710,GIGYF2,WAC,ZNF142,FUBP3,ZN
F540,FGFR1,HPS4,HSF4,C2,CFB,PAIP1,CAPRIN1,CELF1,PAF1,TAB2,
SGK1,DPF2,RNF8,MDM2,RHBDD1,PRKCH,PPM1F,ZNF595,TBP,YY1,I
NO80,GMEB2,PFDN5,CREB1,SRP9,FLII,RPRD1A,DDX58,CCNL2,PTP
RK,ZEB1,EIF4B,CRIP1,SERBP1,ASCC2,RGMB,EBF1,MED28,ZNF3,RP
biol S6KA5,NIPBL,ALKBH3,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,P
ogic RMT5,MAPK8IP3,USP3,MZF1,ZFPM2,TP53BP1,RNF168,ZNF865,SENP
al_p 2,IL18,PUM2,SUB1,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF180,BICD1,Z
roce NF276,NR1H3,USP7,PLD6,FLCN,ZNF605,ZNF410,SAP30BP,VPS72,PT
ss
EN,FYN,SRPK1,RUNX2,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCO
R1,MEF2A,FECH,SETD8,PIAS2,MAPK8,MYCBP2,UPK3B,USP15,DDX4
1,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,UBP1,CDK6,
WDR61,EBF4,ZNF148,ZNF76,AAK1,SP110,NCK2,CTSH,ZSWIM7,TCF4
,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,C3,NFYC,PIWIL4,SRSF10,SS18
,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,INO80E,ZNF44,CREBZF,ING
4,ZNF687,CLK3,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,TMED2,MA
PK12,CCDC59,DCAF6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,ZNF692,GA
PDH,PHF1,STK36,WWP1,PHF12,MED6,MDFI,CIRBP,ZNF554,RGS2,HI
NFP,NCBP2,MLX,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,MKNK2,S
MARCA4,NAA16,LRPPRC,ZNF518B,CLK4,ZNF90,ZNF638,PER3,ZNF3
83,NCOR2,SETD2,IGF2,PTGIS,ATXN3,PSTK,PHF21A,PDCD4,SOX13,
CHD2,STAT6,SON,ZNF138,ZNF705A,NTRK1,TFAM,BRWD1,SMAD9,T
1.11
813
684
6
1.
1
8
E
0
2
GFBR3,ZBTB16,BAZ2A,RRP8,VARS,LARS,PHF19,LMCD1,PKD1,PDPK
1,TSG101,USF1,FOXC1,HEMK1,CDK5RAP3,PABPC1,FASTK,EYA2,SM
ARCAD1,CC2D1A,GATA2
G
O:
00
43
03
9
G
O:
00
43
03
8
G
O:
00
10
00
8
G
O:
00
31
98
5
tRNA aminoacylation
biol
ogic
al_p TARS,NARS,RARS,GARS,FARSA,PPA2,CARS2,VARS,LARS
roce
ss
2.37
752
338
1
amino acid activation
biol
ogic
al_p TARS,NARS,RARS,GARS,FARSA,PPA2,CARS2,VARS,LARS
roce
ss
2.37
752
338
1
endosome membrane
cell
ular
_co
mpo
nent
Golgi cisterna
cell
ular
ST3GAL1,ST3GAL4,GOLGA8B,GOLGA8A,GALNT2,NECAB3,FUT4,TM
_co
ED3,GOLPH3,TMED2,B4GALT4,SCFD1
mpo
nent
HLA-DPB1,PLD1,HGS,HLA-C,HLADQA1,VPS52,NPC1,SLC11A2,VAMP7,HLADMB,TPCN2,TAB2,SNX13,IFITM3,STARD3,CHMP1A,ATP11B,WASH4P
,HLAF,ABCA2,APPL2,LEPROT,RAB10,VPS45,ATP6V0A1,RAB5A,SUN2,MC
OLN1,STAM2,CD164,NTRK1,TSG101,CD63,SCAMP1
1.49
614
196
3
2.07
308
559
6
1.
1
9
E
0
2
1.
1
9
E
0
2
1.
2
1
E
0
2
1.
2
1
E
0
2
G
O:
00
61
13
6
G
O:
00
51
34
8
G
O:
00
04
51
8
G
O:
00
90
30
5
G
O:
00
35
regulation of proteasomal protein catabolic
process
biol
ogic
UBXN1,SMAD7,RAD23A,PRKACA,PLK1,WAC,MDM2,RHBDF1,NUB1,P
al_p
TEN,CSNK1E
roce
ss
2.14
781
097
7
negative regulation of transferase activity
biol
ogic IGF1R,PTPN6,PLK1,CLN8,PPM1F,NF1,RB1,SH3BP5,RGS3,PTEN,PHP
al_p T1,PRKRIP1,CSK,PTPRC,RGS2,GSK3A,PDCD4,CRIPAK,CDK5RAP1,S
roce PRED1,DUSP6,PDPK1,WNK1
ss
1.64
824
759
2
nuclease activity
mol
ecul
ar_f
unct
ion
ACADVL,XRN1,VAPB,RNH1,PNKP,XBP1,RPP14,ASNS,HDGF,ZC3H12
A,RNASET2,SEC31A,DIS3L,G3BP1,LMNA,TPP1,PAN2,RNASEK,HERP
UD1,PARN,ERCC1,PDIA5,REXO2,YIF1A,TLN1,GSK3A,POLG,ERI3
1.56
276
595
nucleic acid phosphodiester bond hydrolysis
biol
ogic
al_p
roce
ss
ACADVL,XRN1,VAPB,RNH1,PNKP,XBP1,RPP14,ASNS,HDGF,ZC3H12
A,RNASET2,SEC31A,DIS3L,G3BP1,LMNA,TPP1,PAN2,RNASEK,CSTF
1,HERPUD1,KPNB1,PARN,ERCC1,PDIA5,REXO2,YIF1A,TLN1,GSK3A,
POLG,ERI3,KPNA1,SMARCAD1
1.51
271
663
1
methylated histone residue binding
mol
ecul
ar_f
unct
CBX5,JHDM1D,TP53BP1,ING4,PHF1,NCAPD3,RRP8,PHF19
2.51
288
611
2
1.
2
2
E
0
2
1.
2
2
E
0
2
1.
2
4
E
0
2
1.
2
4
E
0
2
1.
2
5
E
06
4
G
O:
20
00
13
4
G
O:
00
15
63
1
G
O:
00
50
85
4
G
O:
00
55
01
7
ion
negative regulation of G1/S transition of
mitotic cell cycle
biol
ogic
al_p KANK2,PKD2,SLFN11,PTEN
roce
ss
4.14
542
538
3
tubulin binding
mol
ecul
ar_f
unct
ion
1.68
834
535
6
regulation of antigen receptor-mediated
signaling pathway
biol
ogic
al_p PTPN22,PTPN6,RC3H1,PRKCH,PHPT1,PTPRC
roce
ss
2.99
391
833
2
cardiac muscle tissue growth
biol
ogic
al_p TBX2,FGFR1,RXRB,MEF2A,GSK3A,TGFBR3,FOXC1,TENM4
roce
ss
2.50
653
627
8
VAPB,GPAA1,HDAC6,DYNC1I1,BCL2L11,STARD9,MARK4,PLK1,INO8
0,TRAF3IP1,PAFAH1B1,MAST2,FYN,WASH4P,CDK5RAP2,TBCD,AGB
L5,SUN2,GAPDH,LRPPRC,CLASP1
0
2
1.
2
5
E
0
2
1.
2
6
E
0
2
1.
2
6
E
0
2
1.
2
7
E
0
2
G
O:
00
02
31
2
G
O:
00
09
15
0
G
O:
00
71
55
6
G
O:
00
B cell activation involved in immune
response
biol
ogic
al_p BCL6,RNF8,RNF168,PTPRC,SWAP70,ERCC1,LGALS8,STAT6
roce
ss
purine ribonucleotide metabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,R
GL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DD
X39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DN
M1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,
biol GIT2,MTG1,RAB18,PMS1,ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,IN
ogic O80,RALGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB
al_p 31,ADSL,PKD2,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,
roce FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX41,RNF213,AB
ss
CA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,PSMC4
,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A
,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,ASAP1,RG
S2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,PANK3,DENND6B
2.50
653
627
8
1.
2
7
E
0
2
1.21
234
138
5
1.
2
7
E
0
2
integral to lumenal side of endoplasmic
reticulum membrane
cell
ular
_co HLA-DPB1,HLA-C,HLA-DQA1,PKD2,HLA-F,CANX
mpo
nent
2.99
857
023
7
organelle envelope
cell
ular
_co
1.28
560
608
SLC25A37,ACADVL,RAF1,SLC16A3,TAZ,CBX5,MARCH5,SHMT2,NLN,
PGS1,NUP98,SLC9B2,VRK2,IL15RA,BCL2L13,BCL2L11,STARD13,RA
NBP1,NUTF2,TTC19,DNM1L,FDXR,NPC1,SHISA5,HERC2,NUP210,CN
1.
2
7
E
0
2
1.
2
7
31
96
7
G
O:
19
01
13
5
G
O:
00
08
carbohydrate derivative metabolic process
cell death
mpo P,GCDH,ALDH18A1,TIMM23,CPT1B,GPAT2,LMNA,DHRS1,PAFAH1B1,
nent SENP2,MTCH1,SYNE1,PLD6,KPNB1,SRGAP2,ATP11B,FECH,ERAL1,C
OX7A2L,OSBPL3,NUP37,COX14,PAK1,TIMM50,GRPEL2,DTYMK,GOL
PH3,CDC14B,SUN2,BCS1L,ATP5A1,NDUFV1,NDUFS2,SLC25A6,SDH
A,NUP85,DIABLO,LETMD1,LMNB1,LRPPRC,POLG,FPGS,SFXN3,WDF
Y3,ATXN3,SLC25A24,BNIP2,SLC25A46,LETM1,UQCRH,KPNA1,BCL2L
2
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,SIRT2,RALGAPA2,RAF1,SE
PT5,ATP2B1,COL2A1,RAB34,ST3GAL1,BCL6,CMPK2,GBP3,GPAA1,S
MPD4,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,XYLT1,STARD1
3,ABCC1,DDX23,MPDU1,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PIGS,PDE7B,TBC1D2B,DN
M1L,UPF1,PIGG,NPC1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,PIG
N,TBC1D14,TNK2,GIT2,MTG1,RAB18,ERH,PMS1,ADCY4,PDE4D,PLEK
HG4,NADK,SEC31A,FAM13A,INO80,GPAT2,MCFD2,RALGPS2,NAGK,
biol PLEKHG5,DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB31,ADSL,ALG6,
ogic ST3GAL4,GCNT2,PKD2,GALT,GNAI1,PAFAH1B1,EDEM2,PDE8A,DDX
al_p 6,ACAP2,GALNT2,RGS3,CYTH2,HEXA,FLCN,GMDS,ARHGAP9,UST,IQ
roce GAP1,CTNS,SRGAP2,ATP11B,NECAB3,DDX41,MAN1A2,RNF213,ABC
ss
A2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,PSMC4,
ARHGAP29,SGSM3,GOPC,ST6GALNAC5,RHEB,SEMA4D,GNB3,FUT4,
GRPEL2,TBC1D22A,DTYMK,RAB5A,HGSNAT,MGAT5,ATP5A1,TMED2
,RASGRF2,AK5,GUSB,B4GALT4,EXT1,B3GAT3,ATP8B2,ARHGEF7,AS
AP1,RGS2,MAN2A2,PDGFRB,RAD51B,MAN1B1,FARP1,RAP1B,CANX,
SMARCA4,DHX40,DOCK8,LONRF3,GSK3A,PIGO,PDIA3,MYO1E,PGM
2,RGL2,CHD2,LONP2,ACIN1,PSD3,CTBS,BNIP2,NTRK1,LMF1,SIRT3,
UCK1,DHX37,FOXC1,ACAN,RAPGEF6,FMOD,MTO1,ALG9,PANK3,DE
NND6B,PLA2G16
biol KANK2,CADM1,PSMB10,IGF1R,NOC2L,RAF1,NLRP1,PPP1R13B,BDN
ogic F,SART1,COL2A1,RILPL1,BCL6,CNTF,VAPB,SMAD7,MCF2L,HDAC6,A
al_p RHGEF12,CASP4,LEF1,PAX8,PSMB9,BCL2L13,BCL2L11,NISCH,MAR
roce K4,USP47,ADAM8,NOL3,DNAJC10,XAF1,KRIT1,PTPN6,LHX4,CSNK2A
5
E
0
2
1.16
810
939
3
1.
2
7
E
0
2
1.18
314
902
9
1.
3
0
E
21
9
G
O:
00
02
20
4
G
O:
00
45
19
0
G
O:
00
02
ss
1,IGBP1,NOD1,PLK1,ASNS,JAG2,DNM1L,SHISA5,ZC3H12A,SEPT4,SL
C11A2,CLN8,BCLAF1,GIGYF2,STK4,FGFR1,SNCAIP,SGK1,SHARPIN,
DPF2,TCHP,MDM2,RHBDD1,ZFYVE26,PRKCH,PPM1F,TBP,TNFRSF2
5,PLEKHG5,DFNA5,NF1,CRIP1,COL18A1,RTKN,CAPN10,CASP2,LMN
A,MITF,RB1,ZFPM2,TXNDC5,MFSD10,IL18,MTCH1,TPP1,SYNE1,ANX
A5,GARS,PLK2,HEXA,FLCN,CUL4A,SAP30BP,PTEN,FYN,ALDH1A3,L
GMN,HERPUD1,KPNB1,SRGAP2,LTBR,MEF2A,MAPK8,DDX41,PTPRC
,PSMC6,EMC4,PSMC4,PAK1,SEMA6A,CTSH,TRPM7,SEMA4D,TIMM50
,SMAD4,ING4,GLI3,RASGRF2,NOX4,GAPDH,ERCC1,TEX261,NRBP2,
SLC25A6,ARHGEF7,UNC5B,ITGA5,CDK11A,CARD14,DIABLO,MKNK2,
LMNB1,FGF14,POLG,PDIA3,PTGIS,ATXN3,PDCD4,PSMA1,ACIN1,RO
BO2,SON,BNIP2,NTRK1,TNFRSF10B,ATG3,HBB,DUSP6,ZBTB16,RRP
8,LUC7L3,PDPK1,FOXC1,KPNA1,DDAH2,STK24,FASTK,EYA2,BCL2L2
-PABPN1,BCL2L2
0
2
somatic recombination of immunoglobulin
genes involved in immune response
biol
ogic
al_p BCL6,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.69
452
649
9
isotype switching
biol
ogic
al_p BCL6,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.69
452
649
9
somatic diversification of immunoglobulins
involved in immune response
biol
ogic
BCL6,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
al_p
roce
2.69
452
649
9
1.
3
0
E
0
2
1.
3
0
E
0
2
1.
3
0
E
20
8
G
O:
19
01
65
7
G
O:
00
31
26
7
G
O:
00
43
16
1
ss
0
2
glycosyl compound metabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,SEPT5,ATP2B1,
RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,RGL4,S
TARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DDX39A,
KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,TBC1D2B,DNM1L,UPF1,H
ERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,GIT2,MTG1,R
biol
AB18,ERH,PMS1,PLEKHG4,NADK,FAM13A,INO80,RALGPS2,PLEKHG
ogic
5,DDX58,SNX13,NF1,RTKN,G3BP1,RAB31,ADSL,GNAI1,PAFAH1B1,D
al_p
DX6,ACAP2,RGS3,CYTH2,FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,A
roce
TP11B,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,PSMC6,TBCD,IMP
ss
DH1,SKIV2L2,PSMC4,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB
3,GRPEL2,TBC1D22A,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2
,ARHGEF7,ASAP1,RGS2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,D
OCK8,LONRF3,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK
1,UCK1,DHX37,RAPGEF6,MTO1,PANK3,DENND6B
1.21
728
226
2
small GTPase binding
mol
ecul
ar_f
unct
ion
RAF1,GAS8,SYTL4,RANBP1,PRKCH,RTKN,SYTL2,BICD1,DAAM1,IQG
AP1,SRGAP2,RAB8A,SGSM3,RANBP9,ERC1,FLNA,RAP1B,RAPGEF6
1.76
175
167
6
proteasomal ubiquitin-dependent protein
catabolic process
biol
ogic CRBN,PSMB10,SIRT2,SPOP,UBXN1,SMAD7,DERL2,PSMB9,RAD23A,
al_p DNAJC10,ANAPC4,PLK1,WAC,MDM2,RHBDD1,NUB1,PTEN,FBXW7,P
roce SMC6,PSMC4,OS9,WWP1,MAN1B1,ATXN3,AMFR,PSMA1,CSNK1E
ss
1.56
793
567
8
1.
3
2
E
0
2
1.
3
2
E
0
2
1.
3
3
E
0
2
G
O:
00
05
16
0
G
O:
00
16
26
5
G
O:
00
60
21
6
transforming growth factor beta receptor
binding
mol
ecul
ar_f
unct
ion
death
KANK2,CADM1,PSMB10,IGF1R,NOC2L,RAF1,NLRP1,PPP1R13B,BDN
F,SART1,COL2A1,RILPL1,BCL6,CNTF,VAPB,SMAD7,MCF2L,HDAC6,A
RHGEF12,CASP4,LEF1,PAX8,PSMB9,BCL2L13,BCL2L11,NISCH,MAR
K4,USP47,ADAM8,NOL3,DNAJC10,XAF1,KRIT1,PTPN6,LHX4,CSNK2A
1,IGBP1,NOD1,PLK1,ASNS,JAG2,DNM1L,SHISA5,ZC3H12A,SEPT4,SL
C11A2,CLN8,BCLAF1,GIGYF2,STK4,FGFR1,SNCAIP,SGK1,SHARPIN,
DPF2,TCHP,MDM2,RHBDD1,ZFYVE26,PRKCH,PPM1F,TBP,TNFRSF2
biol
5,PLEKHG5,DFNA5,NF1,CRIP1,COL18A1,RTKN,CAPN10,CASP2,LMN
ogic
A,MITF,RB1,ZFPM2,TXNDC5,MFSD10,IL18,MTCH1,TPP1,SYNE1,ANX
al_p
A5,GARS,PLK2,HEXA,FLCN,CUL4A,SAP30BP,PTEN,FYN,ALDH1A3,L
roce
GMN,HERPUD1,KPNB1,SRGAP2,LTBR,MEF2A,MAPK8,DDX41,PTPRC
ss
,PSMC6,EMC4,PSMC4,PAK1,SEMA6A,CTSH,TRPM7,SEMA4D,TIMM50
,SMAD4,ING4,GLI3,RASGRF2,NOX4,GAPDH,ERCC1,TEX261,NRBP2,
SLC25A6,ARHGEF7,UNC5B,ITGA5,CDK11A,CARD14,DIABLO,MKNK2,
LMNB1,FGF14,POLG,PDIA3,PTGIS,ATXN3,PDCD4,PSMA1,ACIN1,RO
BO2,SON,BNIP2,NTRK1,TNFRSF10B,ATG3,HBB,DUSP6,ZBTB16,RRP
8,LUC7L3,PDPK1,FOXC1,KPNA1,DDAH2,STK24,FASTK,EYA2,BCL2L2
-PABPN1,BCL2L2
definitive hemopoiesis
biol
ogic
al_p NCOR1,RUNX1,SMARCA4,TGFBR3,GATA2
roce
ss
SMAD7,FKBP1A,USP15,ENG,TGFBR3
3.37
669
071
2
1.
3
4
E
0
2
1.18
180
986
8
1.
3
5
E
0
2
3.36
815
812
3
1.
3
5
E
0
2
G
O:
00
07
34
6
G
O:
00
31
02
3
G
O:
00
03
92
4
regulation of mitotic cell cycle
biol
ogic
al_p
roce
ss
microtubule organizing center organization
biol
ogic
CEP135,RANBP1,PLK1,PKD2,PAFAH1B1,GCC2,PLK2,CDK5RAP2,HA
al_p
US5,BNIP2,CLASP1
roce
ss
KANK2,PSMB10,SIRT2,CDK13,BCL6,PSMB9,USP47,RANBP1,PTPN6,
CSNK2A1,ANAPC4,PLK1,ASNS,PAF1,MDM2,INO80,PKD2,CASP2,RB1,
PRMT5,PAFAH1B1,SLFN11,CHMP1A,PLK2,CUL4A,CHFR,PTEN,PSMC
6,PSMC4,DGKZ,PDGFRB,SMARCA4,IGF2,PSMA1,FOXC1
RAB3GAP2,EIF2B4,RALGAPA2,SEPT5,RAB34,BCL6,GBP3,MCF2L,AR
HGEF12,ARHGEF25,RGL4,STARD13,RAB35,RANBP1,SIPA1L1,KRIT1,
MINK1,RHOF,EEF1A1,TBC1D2B,DNM1L,HERC2,TBC1D10B,SEPT4,EF
TUD2,TBC1D14,TNK2,GIT2,MTG1,RAB18,PLEKHG4,FAM13A,RALGPS
2,PLEKHG5,SNX13,NF1,RTKN,RAB31,GNAI1,PAFAH1B1,ACAP2,RGS
3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,DENND4C,MAP4K4,TBCD,ARH
GAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,TBC1D22A,RAB5A,TMED
2,RASGRF2,ARHGEF7,ASAP1,RGS2,FARP1,RAP1B,DOCK8,RGL2,PS
D3,BNIP2,NTRK1,RAPGEF6,DENND6B
1.47
356
917
9
2.11
712
796
3
GTPase activity
mol
ecul
ar_f
unct
ion
G
O:
00
05
76
9
early endosome
cell
ular
_co
mpo
nent
USP10,RAB34,HGS,DERL2,HLAC,NISCH,MIB2,SLC11A2,SNX13,RAB31,CHMP1A,PTP4A2,CTNS,SNX1
7,ATP11B,WASH4P,HLAF,APPL2,RAB5A,STAM2,SNX27,NTRK1,TSG101
1.63
373
877
6
G
O:
ribonucleotide metabolic process
biol
ogic
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,R
1.20
809
1.29
767
275
1.
3
5
E
0
2
1.
3
6
E
0
2
1.
3
7
E
0
2
1.
3
7
E
0
2
1.
3
00
09
25
9
G
O:
00
43
41
4
G
O:
00
31
32
9
G
O:
19
01
al_p GL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DD
roce X39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DN
ss
M1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,
GIT2,MTG1,RAB18,PMS1,ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,IN
O80,RALGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB
31,ADSL,PKD2,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,
FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX41,RNF213,AB
CA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,PSMC4
,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A
,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,ASAP1,RG
S2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,UCK1,DHX37
,RAPGEF6,PANK3,DENND6B
macromolecule methylation
regulation of cellular catabolic process
organic substance biosynthetic process
biol
ogic EED,EHMT1,PRMT10,METTL3,PRMT5,NTMT1,USP7,PLD6,SETD8,N6
al_p AMT1,WDR61,WDR4,PIWIL4,PHF1,TGS1,SMARCA4,SETD2,FTSJ3,BA
roce Z2A,PHF19,HEMK1
ss
USP10,RAB3GAP2,RALGAPA2,SUPT5H,UBXN1,BCL6,SMAD7,ARHGE
F12,STARD13,RAD23A,ADAM8,DNAJC10,RANBP1,SIPA1L1,PRKACA,
biol
PLK1,TBC1D2B,NPC1,ZC3H12A,TBC1D10B,ATG4B,TBC1D14,GIT2,W
ogic
AC,MDM2,FAM13A,SNX13,RHBDF1,NF1,NUB1,PAFAH1B1,ACAP2,RG
al_p
S3,ARHGAP9,PTEN,IQGAP1,FBXW7,SRGAP2,NCOR1,TBCD,ARHGAP
roce
29,SGSM3,PHKG2,SEMA4D,TBC1D22A,TMED2,ARNT,NRBP2,ARHGE
ss
F7,ASAP1,RGS2,GSK3A,LONP2,CSNK1E,BNIP2,NTRK1,RAPGEF6,PA
BPC1
biol FZD6,OBFC1,PBX2,KANK2,ACADVL,EIF2B4,GTF3C2,RAI1,IGF1R,PTS
ogic ,TNRC6A,SIRT2,MYNN,TRNAU1AP,NOC2L,TARS,RAF1,ZNF131,RSC1
al_p A1,SFSWAP,CDK13,TAZ,SIN3B,CBX5,SUPT5H,SUPT20H,ST3GAL1,P
roce WP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,SHMT2,EEF2K,PLD1
114
9
7
E
0
2
1.67
411
409
7
1.
3
7
E
0
2
1.33
803
541
9
1.
3
9
E
0
2
1.08
772
661
9
1.
4
1
E
57
6
ss
,VAPB,GPAA1,CUX1,PGS1,NUP98,EED,FMR1,SMPD4,SMAD7,MCF2L,
HDAC6,EHMT1,ZNF496,NARS,LANCL2,PNKP,LEF1,GLS,PAX8,SUPT4
H1,ZNF83,EMX2,RBPMS,XYLT1,ZSCAN31,XBP1,FDPS,PAM,HSD17B1
2,APITD1,MPDU1,UHMK1,USP47,ADAM8,POLR3E,GABPB1,PCGF6,E
EF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,PIGS,PL
K1,ZNF446,PNPO,ASNS,PTGES2,UPF1,ZNF621,HDGF,FDXR,PPP5C,
PIGG,PDXK,NPC1,CCNL1,CHD6,ZC3H12A,SLC11A2,FAM58A,CLN8,T
BX18,PIGN,GCDH,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1
D,ZNF710,GIGYF2,WAC,ZNF142,FUBP3,RARS,ZNF540,ALDH18A1,FG
FR1,HSF4,PAIP1,CAPRIN1,GTF3C1,NADSYN1,ADCY4,CELF1,PAF1,T
AB2,SGK1,DPF2,CHKB,NADK,IDI1,RNF8,SEC31A,MDM2,PRKCH,PPM
1F,ZNF595,TBP,YY1,INO80,GPAT2,GMEB2,MCFD2,PFDN5,CREB1,SR
P9,FLII,RPRD1A,DDX58,RPL27,CCNL2,PTPRK,SERPINH1,NF1,ZEB1,
EIF4B,IFITM3,ASCC2,RGMB,EBF1,RPL9,MED28,NPR1,ZNF3,RPS6KA
5,NIPBL,ADSL,ALG6,ST3GAL4,BRD9,GCNT2,ZNF837,PKD2,RXRB,LM
NA,RSL1D1,MITF,NOL8,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,RNF168,
ZNF865,SENP2,ISYNA1,EDEM2,GPCPD1,IL18,PUM2,STARD3,SUB1,C
HMP1A,PDE8A,ZNF558,GALNT2,ZNF263,ZNF180,BICD1,ZNF276,NR1
H3,GARS,GRB10,MRPS7,USP7,PLD6,FLCN,ZNF605,ZNF410,GMDS,R
PL24,UST,MTMR14,RPL37A,SAP30BP,MAST2,VPS72,PTEN,ALDH1A3,
RNASEK,RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCO
R1,PPP1R10,MEF2A,FECH,SETD8,SMEK1,NECAB3,PIAS2,SSBP1,MA
PK8,MYCBP2,USP15,DDX41,MAN1A2,PBX3,ZNF565,ABCA2,AFF4,TRI
M28,DMTF1,CDK5RAP2,PTPRC,OAZ1,IMPDH1,UBP1,WDR61,EBF4,F
ARSA,ZNF148,ZNF76,STAG2,SP110,PPA2,ST6GALNAC5,PHKG2,NCK
2,TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,C3,NFYC,HSD17B
4,ELOVL1,FUT4,PIWIL4,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHU
RC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,INO80E,DTYMK,RPL4,MTRR
,MBOAT2,ZNF44,CREBZF,ING4,CD276,RBMS1,EIF3M,ZNF687,NR2C2,
FHOD1,DNTTIP2,MRPL49,FLNA,IRF9,MGAT5,ATP5A1,GLI3,THNSL2,M
APK12,CCDC59,DCAF6,AK5,B4GALT4,ENG,SIRT7,ZSCAN5A,TCF12,A
0
2
RNT,NOX4,ZNF692,EXT1,GAPDH,PHF1,MTRF1L,B3GAT3,STK36,WW
P1,PHF12,TBCE,MED6,MDFI,CIRBP,ZNF554,CIZ1,RGS2,HINFP,NCBP
2,MAN2A2,LPCAT1,MLX,PDGFRB,TGS1,CDK11A,MAN1B1,GLIS3,ELP
6,BDP1,DBF4,CANX,RUNX1,MKNK2,SMARCA4,NAA16,LRPPRC,RPLP
0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3,CHTF8,GSK3A,SNR
PE,POLG,ZNF383,MRPL3,POLR2J3,NCOR2,FPGS,SETD2,PCYT1A,PI
GO,PPAP2A,PDIA3,IGF2,PTGIS,TROVE2,ATXN3,PSTK,PHF21A,GPHN
,PDCD4,SOX13,PGM2,CHD2,STAT6,CARS2,ZNF138,ZNF705A,NTRK1,
TFAM,PHKG1,BRWD1,SMAD9,LMF1,TGFBR3,ZBTB16,BAZ2A,SIRT3,U
CK1,SPCS3,EIF3I,RRP8,VARS,LARS,PHF19,LMCD1,PKD1,PDPK1,TS
G101,USF1,FOXC1,ACAN,CDK5RAP3,FMOD,ALG9,PABPC1,PANK3,E
YA2,SMARCAD1,CC2D1A,PLA2G16,GATA2,PABPN1
G
O:
00
04
81
2
G
O:
00
16
87
6
G
O:
00
16
87
5
aminoacyl-tRNA ligase activity
mol
ecul
ar_f
unct
ion
ligase activity, forming aminoacyl-tRNA and
related compounds
mol
ecul
ar_f
unct
ion
ligase activity, forming carbon-oxygen
bonds
mol
ecul
ar_f
unct
ion
TARS,NARS,RARS,GARS,FARSA,CARS2,VARS,LARS
2.45
577
506
4
TARS,NARS,RARS,GARS,FARSA,CARS2,VARS,LARS
2.45
577
506
4
TARS,NARS,RARS,GARS,FARSA,CARS2,VARS,LARS
2.45
577
506
4
1.
4
3
E
0
2
1.
4
3
E
0
2
1.
4
3
E
0
2
G
O:
00
45
93
4
G
O:
20
00
04
5
G
O:
00
43
39
3
G
O:
00
30
19
8
negative regulation of nucleobasecontaining compound metabolic process
KANK2,SIRT2,NOC2L,SFSWAP,SIN3B,CBX5,SUPT5H,BCL6,TBX2,CU
X1,EED,SMAD7,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,USP
47,PCGF6,IGBP1,PLK1,HDGF,TBX18,DR1,BCLAF1,ZNF540,FGFR1,HS
biol
F4,PAF1,MDM2,PPM1F,YY1,PFDN5,CREB1,PTPRK,ZEB1,IFITM3,RPS
ogic
6KA5,NIPBL,RB1,PRMT5,ZFPM2,CHMP1A,ZNF263,NR1H3,FLCN,VPS7
al_p
2,RUNX2,FBXW7,NCOR1,MEF2A,SETD8,TRIM28,UBP1,ZNF148,STAG
roce
2,TCF4,ACD,SEMA4D,SRSF10,SMAD4,CREBZF,ING4,GLI3,ENG,SIRT
ss
7,ERCC1,WWP1,PHF12,MDFI,HINFP,MLX,GLIS3,SMARCA4,PER3,GS
K3A,NCOR2,PHF21A,PDCD4,STAT6,ZBTB16,BAZ2A,RRP8,LMCD1,TS
G101,PABPC1,UBR5,CC2D1A,GATA2
regulation of G1/S transition of mitotic cell
cycle
biol
ogic
KANK2,PSMB10,PSMB9,PTPN6,MDM2,INO80,PKD2,CASP2,SLFN11,P
al_p
TEN,PSMC6,PSMC4,DGKZ,PSMA1
roce
ss
1.90
522
075
7
regulation of protein binding
biol
ogic
CRBN,LEF1,KRIT1,PLK1,FKBP1A,SENP2,NRP1,SMARCD3,HERPUD1,
al_p
MEF2A,MAPK8,LRPAP1,TGFBR3,PKD1
roce
ss
1.90
522
075
7
extracellular matrix organization
biol
ogic
al_p
roce
ss
1.58
875
383
2
LEPRE1,COL9A1,COL2A1,DPP4,HSD17B12,COL16A1,COL14A1,MMP
16,COL12A1,FKBP1A,SERPINH1,NF1,COL18A1,FAP,COL9A3,ABI3BP,
P4HB,ENG,COL8A1,SMARCA4,COL13A1,MYO1E,PLOD2,FOXC1,ACA
N
1.25
391
615
8
1.
4
3
E
0
2
1.
4
4
E
0
2
1.
4
4
E
0
2
1.
4
4
E
0
2
G
O:
00
12
50
7
ER to Golgi transport vesicle membrane
cell
ular
_co HLA-DPB1,HLA-C,HLA-DQA1,SEC31A,MCFD2,HLA-F,SEC31B
mpo
nent
2.64
738
633
5
cilium assembly
biol
ogic
TTLL3,BBS1,IFT172,RAB8A,WDR35,FLNA,STK36,DZIP1,CC2D2A,TME
al_p
M237,SEPT2,C2CD3
roce
ss
2.02
089
487
4
post-Golgi vesicle-mediated transport
biol
ogic
VAMP7,BBS1,SNAP23,RAB31,TXNDC5,GCC2,CSK,GOPC,RAB10,SCF
al_p
D1,VAMP4,SCAMP1
roce
ss
2.02
089
487
4
G
O:
00
05
71
9
nuclear euchromatin
cell
ular
_co TBP,CREB1,TRIM28,SMARCA4
mpo
nent
3.99
809
364
9
G
O:
negative regulation of signal transduction
biol
ogic
1.31
095
G
O:
00
42
38
4
G
O:
00
06
89
2
FZD6,KANK2,IGF1R,NPHP3,BCL6,PTPN22,SMAD7,GLG1,ARHGEF12,
HGS,LEF1,PTPN6,IGBP1,TBX18,STK4,MDM2,PFDN5,SNX13,NF1,G3B
1.
4
5
E
0
2
1.
4
5
E
0
2
1.
4
5
E
0
2
1.
4
6
E
0
2
1.
4
00
09
96
8
G
O:
00
05
96
4
G
O:
00
05
59
4
G
O:
00
31
61
8
G
O:
00
55
08
al_p P1,RB1,PAFAH1B1,BICD1,RGS3,NR1H3,GRB10,FLCN,PTEN,FYN,RU
roce NX2,FBXW7,PHPT1,RQCD1,NCOR1,PIAS2,USP15,CSK,PTPRC,LEPR
ss
OT,DGKZ,TGFB1I1,LRPAP1,GLI3,EPS15L1,EPN1,ENG,BICC1,ARHGE
F7,UNC5B,MDFI,RGS2,STAM2,SMARCA4,ADRBK2,GSK3A,ANKRD6,P
DCD4,SNX14,CRIPAK,CSNK1E,SPRED1,DUSP6,TGFBR3,PDPK1,GAT
A2
974
9
phosphorylase kinase complex
cell
ular
_co PHKG2,PHKG1
mpo
nent
9.32
888
518
2
collagen type IX
cell
ular
_co COL9A1,COL9A3
mpo
nent
9.32
888
518
2
nuclear centromeric heterochromatin
cell
ular
_co CBX5,NCAPD3
mpo
nent
9.32
888
518
2
Ski complex
cell
ular
_co SKIV2L,WDR61
mpo
nent
9.32
888
518
2
6
E
0
2
1.
4
6
E
0
2
1.
4
6
E
0
2
1.
4
6
E
0
2
1.
4
6
E
-
7
G
O:
00
71
59
8
G
O:
00
71
43
8
G
O:
00
42
59
4
G
O:
00
10
64
8
neuronal ribonucleoprotein granule
cell
ular
_co FMR1,UHMK1
mpo
nent
9.32
888
518
2
invadopodium membrane
cell
ular
_co DPP4,FAP
mpo
nent
9.32
888
518
2
response to starvation
biol
ogic
TNRC6A,SUPT5H,HDAC6,ASNS,NPC1,ATG4B,TBC1D14,WAC,ATG12,
al_p
ADSL,AACS,OXCT1,NRBP2,ATG3,RRP8
roce
ss
1.85
403
199
5
negative regulation of cell communication
FZD6,KANK2,IGF1R,NPHP3,BCL6,PTPN22,SMAD7,GLG1,ARHGEF12,
HGS,LEF1,PTPN6,IGBP1,NPC1,TBX18,STK4,MDM2,PFDN5,SNX13,NF
biol
1,G3BP1,RB1,PAFAH1B1,BICD1,RGS3,NR1H3,GRB10,PLK2,FLCN,PT
ogic
EN,FYN,RUNX2,FBXW7,PHPT1,RQCD1,NCOR1,PIAS2,USP15,CSK,PT
al_p
PRC,LEPROT,DGKZ,TGFB1I1,LRPAP1,GLI3,EPS15L1,EPN1,ENG,BIC
roce
C1,NRBP2,ARHGEF7,UNC5B,MDFI,RGS2,STAM2,SMARCA4,ADRBK2,
ss
GSK3A,ANKRD6,PDCD4,SNX14,CRIPAK,CSNK1E,SPRED1,DUSP6,TG
FBR3,PDPK1,GATA2
1.30
133
382
0
2
1.
4
6
E
0
2
1.
4
6
E
0
2
1.
4
6
E
0
2
1.
4
8
E
0
2
G
O:
00
31
59
3
G
O:
00
05
15
8
G
O:
00
44
38
9
G
O:
00
31
62
5
G
O:
00
60
polyubiquitin binding
mol
ecul
ar_f
unct
ion
UBXN1,HDAC6,RAD23A,TAB2,SHARPIN,RNF168
2.89
430
632
5
insulin receptor binding
mol
ecul
ar_f
unct
ion
IGF1R,TLN2,GRB10,TLN1,IGF2,PDPK1
2.89
430
632
5
small conjugating protein ligase binding
mol
ecul
ar_f
unct
ion
FZD6,SPOP,UBXN1,SMAD7,PRKACA,DNM1L,HERC2,SNCAIP,PDE4D,
RNF8,RB1,USP7,CUL4A,LTBR,TRIM28,TANK,TNFRSF14,ATXN3,TSG1
01
1.71
085
662
8
ubiquitin protein ligase binding
mol
ecul
ar_f
unct
ion
FZD6,SPOP,UBXN1,SMAD7,PRKACA,DNM1L,HERC2,SNCAIP,PDE4D,
RNF8,RB1,USP7,CUL4A,LTBR,TRIM28,TANK,TNFRSF14,ATXN3,TSG1
01
1.71
085
662
8
artery development
biol
ogic
TBX2,SMAD7,NF1,PKD2,MYLK,GLI3,ENG,PDGFRB,FOXC1
al_p
roce
2.28
780
551
8
1.
4
9
E
0
2
1.
4
9
E
0
2
1.
4
9
E
0
2
1.
4
9
E
0
2
1.
5
2
E
84
0
G
O:
00
19
69
3
G
O:
00
43
06
2
G
O:
00
05
90
5
ss
0
2
ribose phosphate metabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,R
GL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DD
X39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DN
M1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,
biol GIT2,MTG1,RAB18,PMS1,ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,IN
ogic O80,RALGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB
al_p 31,ADSL,PKD2,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,
roce FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX41,RNF213,AB
ss
CA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,PSMC4
,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A
,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,ASAP1,RG
S2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,UCK1,DHX37
,RAPGEF6,PANK3,DENND6B
extracellular structure organization
biol
ogic
al_p
roce
ss
coated pit
cell
ular
_co RAB35,TNK2,REPS1,CLTCL1,CLTB,AAK1,EPS15L1,EPN1,LRP3
mpo
nent
LEPRE1,COL9A1,COL2A1,DPP4,HSD17B12,COL16A1,COL14A1,MMP
16,COL12A1,FKBP1A,SERPINH1,NF1,COL18A1,FAP,COL9A3,ABI3BP,
P4HB,ENG,COL8A1,SMARCA4,COL13A1,MYO1E,PLOD2,FOXC1,ACA
N
1.20
377
345
4
1.58
129
489
4
2.28
981
727
2
1.
5
2
E
0
2
1.
5
2
E
0
2
1.
5
2
E
0
2
G
O:
00
31
41
0
G
O:
00
01
70
1
G
O:
00
00
27
8
G
O:
00
31
51
cytoplasmic vesicle
in utero embryonic development
mitotic cell cycle
motile primary cilium
CADM1,SEPT5,BDNF,CPE,RAB34,HLADPB1,DPP4,HGS,IL15RA,SYTL4,HLAC,YIPF1,ADAMTS1,RGL4,PAM,HLAcell DQA1,AP3S2,ADAM8,RAB35,CD9,SLC11A2,CNP,VAMP7,CAMK2D,TN
ular K2,FLG,VTI1A,FGFR1,HPS4,SEC31A,MDM2,SNAP23,MCFD2,SNX21,R
_co AB31,GNAI1,BLOC1S5,TPP1,SYTL2,EPN2,ADAM15,BICD1,GARS,NRP
mpo 1,STX2,SNX17,GGNBP2,SRGAP2,ITGB5,CLTCL1,HLAnent F,ABCA2,RAB8A,DENND4C,CLTB,FLOT1,AAK1,GOPC,RAB10,CTSH,A
TP6V0A1,P4HB,TMED3,CLK3,RAB5A,TMED2,VEZT,SCFD1,PDGFRB,V
PS51,CANX,PTPN23,CRCP,PDIA3,MYO1E,CORO7,DPP7,CLIC4,NTRK
1,CTTNBP2,SEC31B,ZDHHC8,PDPK1,CD63
biol
ogic
al_p
roce
ss
PLCD1,LEF1,BCL2L11,JAG2,STK4,FGFR1,PKD2,RXRB,MAPK8IP3,ZF
PM2,EPN2,FLCN,TCTN1,TRIM28,RARRES2,PSMC4,SMAD4,GLI3,TME
D2,EPN1,ARNT,MDFI,HINFP,PDGFRB,RUNX1,SMARCA4,NCOR2,SET
D2,MYO1E,BNIP2,TGFBR3,EGFL8,PKD1,FOXC1,C2CD3,GATA2
CDK14,KANK2,PSMB10,SIRT2,CDK13,BCL6,NUP98,PSMB9,CEP135,A
PITD1,USP47,RANBP1,PTPN6,CSNK2A1,PRKACA,ANAPC4,PLK1,SDC
biol CAG8,ASNS,PPP5C,CAMK2D,GIGYF2,PAF1,RNF8,MDM2,ANAPC16,IN
ogic O80,NEK3,NUMA1,NIPBL,PKD2,CASP2,RB1,PRMT5,USP3,PAFAH1B1,
al_p SLFN11,CHMP1A,PLK2,CUL4A,CHFR,PTEN,SETD8,CLTCL1,CDK5RA
roce P2,PSMC6,DSN1,CDK6,NUP37,PSMC4,STAG2,DGKZ,CENPT,CDCA3,
ss
FLNA,SUN2,SIRT7,NUP85,HAUS5,HINFP,PDGFRB,NCAPD3,CDK11A,
DBF4,SMARCA4,IGF2,DYNC1I2,MAU2,PSMA1,CSNK1E,SEPT2,PKD1,
FOXC1,CLASP1,GORASP1
cell
ular
_co PKD2,PAFAH1B1,PKD1
mpo
nent
1.26
255
588
9
1.
5
3
E
0
2
1.45
214
002
9
1.
5
3
E
0
2
1.28
066
848
8
1.
5
4
E
0
2
5.24
749
791
5
1.
5
5
E
-
2
G
O:
00
04
44
9
isocitrate dehydrogenase (NAD+) activity
mol
ecul
ar_f
unct
ion
carbon-oxygen lyase activity, acting on
phosphates
mol
ecul
ar_f
unct
ion
amidine-lyase activity
mol
ecul
ar_f
unct
ion
G
O:
00
10
99
7
G
O:
G
O:
00
16
83
8
G
O:
00
16
84
2
IDH3G,IDH3B
9.00
450
856
6
PTS,THNSL2
9.00
450
856
6
PAM,ADSL
9.00
450
856
6
anaphase-promoting complex binding
mol
ecul
ar_f
unct
ion
PLK1,PTEN
9.00
450
856
6
organelle fission
biol
ogic
SIRT2,CDK13,MARCH5,NUP98,APITD1,RANBP1,ANAPC4,PLK1,DNM1
L,PPP5C,RNF8,ANAPC16,INO80,NEK3,NUMA1,NIPBL,RB1,PRMT5,PA
1.41
273
0
2
1.
5
6
E
0
2
1.
5
6
E
0
2
1.
5
6
E
0
2
1.
5
6
E
0
2
1.
5
00
48
28
5
G
O:
00
42
81
6
G
O:
00
35
16
6
G
O:
00
07
18
1
G
O:
00
36
09
3
al_p FAH1B1,CHMP1A,CHFR,PTEN,SETD8,CLTCL1,DSN1,NUP37,STAG2,
roce CENPT,CDCA3,FLNA,NUP85,HAUS5,PDGFRB,NCAPD3,CDK11A,IGF2
ss
,MAU2,ATG3,SEPT2,CLASP1,GORASP1
128
4
vitamin B6 metabolic process
biol
ogic
al_p PNPO,PDXK
roce
ss
8.98
175
499
6
post-embryonic hemopoiesis
biol
ogic
al_p ERCC1,MYO1E
roce
ss
8.98
175
499
6
transforming growth factor beta receptor
complex assembly
biol
ogic
al_p TGFBR3,FMOD
roce
ss
8.98
175
499
6
germ cell proliferation
biol
ogic
al_p RHBDD1,IL18
roce
ss
8.98
175
499
6
6
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
G
O:
00
42
99
7
negative regulation of Golgi to plasma
membrane protein transport
biol
ogic
al_p CSK,GOPC
roce
ss
8.98
175
499
6
pyrimidine deoxyribonucleoside
diphosphate metabolic process
biol
ogic
al_p CMPK2,DTYMK
roce
ss
8.98
175
499
6
nucleotide-sugar catabolic process
biol
ogic
al_p GALT,GSK3A
roce
ss
8.98
175
499
6
G
O:
00
02
17
6
male germ cell proliferation
biol
ogic
al_p RHBDD1,IL18
roce
ss
8.98
175
499
6
G
O:
negative regulation of extracellular matrix
disassembly
biol
ogic
8.98
175
G
O:
00
09
19
6
G
O:
00
09
22
7
DPP4,FAP
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
00
10
71
6
G
O:
00
51
59
9
G
O:
00
90
29
2
G
O:
00
90
18
8
G
O:
00
61
08
7
al_p
roce
ss
499
6
response to hydrostatic pressure
biol
ogic
al_p PKD2,NTRK1
roce
ss
8.98
175
499
6
nuclear matrix anchoring at nuclear
membrane
biol
ogic
al_p SYNE1,SUN2
roce
ss
8.98
175
499
6
negative regulation of pancreatic juice
secretion
biol
ogic
al_p NR1H3,WNK1
roce
ss
8.98
175
499
6
positive regulation of histone H3-K27
methylation
biol
ogic
al_p PHF1,PHF19
roce
ss
8.98
175
499
6
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
G
O:
00
36
29
7
interstrand cross-link repair
biol
ogic
al_p RNF8,RNF168
roce
ss
8.98
175
499
6
muscle cell fate determination
biol
ogic
al_p TBX2,MEF2A
roce
ss
8.98
175
499
6
regulation of centromere complex assembly
biol
ogic
al_p RB1,SENP6
roce
ss
8.98
175
499
6
G
O:
00
35
44
1
cell migration involved in vasculogenesis
biol
ogic
al_p PDGFRB,SETD2
roce
ss
8.98
175
499
6
G
O:
pyrimidine deoxyribonucleoside
diphosphate biosynthetic process
biol
ogic
8.98
175
G
O:
00
07
52
1
G
O:
00
90
23
0
CMPK2,DTYMK
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.
5
00
09
19
7
G
O:
00
02
37
8
G
O:
00
09
13
9
G
O:
00
44
42
9
G
O:
00
30
13
al_p
roce
ss
499
6
immunoglobulin biosynthetic process
biol
ogic
al_p GALNT2,PTPRC
roce
ss
8.98
175
499
6
pyrimidine nucleoside diphosphate
biosynthetic process
biol
ogic
al_p CMPK2,DTYMK
roce
ss
8.98
175
499
6
mitochondrial part
endocytic vesicle
SLC25A37,ACADVL,RAF1,TAZ,MARCH5,SHMT2,NLN,PGS1,SLC9B2,V
RK2,GLS,BCL2L13,BCL2L11,STARD13,TTC19,DNM1L,FDXR,HERC2,C
cell
NP,GCDH,ALDH18A1,TIMM23,CPT1B,IDH3G,GPAT2,ALDH6A1,DHRS1
ular
,MTCH1,GARS,PLD6,SRGAP2,OXCT1,FECH,ERAL1,COX7A2L,SSBP1,
_co
COX14,PPA2,TIMM50,GRPEL2,DTYMK,GOLPH3,DLST,MRPL49,CA5B,
mpo
BCS1L,ATP5A1,NDUFV1,NDUFS2,ETFA,SLC25A6,SDHA,IDH3B,DIABL
nent
O,LETMD1,LRPPRC,POLG,MRPL3,FPGS,SFXN3,D2HGDH,ATXN3,CA
RS2,SLC25A24,TFAM,SLC25A46,SIRT3,LETM1,UQCRH,BCL2L2
cell
ular RAB34,HLA-DPB1,DPP4,HLA-C,HLA_co DQA1,ADAM8,RAB35,VAMP7,CAMK2D,MDM2,RAB31,EPN2,SRGAP2,I
mpo TGB5,HLA-F,RAB8A,RAB10,ATP6V0A1,RAB5A,MYO1E
nent
7
E
0
2
1.
5
7
E
0
2
1.
5
7
E
0
2
1.29
225
982
1
1.
5
9
E
0
2
1.67
584
763
8
1.
5
9
E
-
9
G
O:
00
04
72
1
phosphoprotein phosphatase activity
G
O:
00
09
89
3
positive regulation of metabolic process
G
O:
negative regulation of transcription, DNAdependent
mol
ecul
ar_f
unct
ion
PTPN22,PTPN6,CSNK2A1,IGBP1,PPP5C,FKBP1A,PPM1F,SSH2,PTPR
K,MDP1,TENC1,MTMR14,PTEN,PHPT1,PTP4A2,PTPRF,PPP1R10,PTP
RS,PTPRC,TIMM50,CDC14B,PTPRD,PDGFRB,PTPN4,PTPN23,DUSP6
,SSH1,EYA2
OBFC1,PBX2,ACADVL,PSMB10,IGF1R,EPHX2,RAF1,SUPT5H,FUBP1,
MMS19,ZFP91,CNTF,VAPB,SMAD7,MCF2L,HDAC6,ZNF496,LEF1,PAX
8,SUPT4H1,PSMB9,RBPMS,XBP1,APITD1,UHMK1,ADAM8,GABPB1,C
SNK2A1,IGBP1,UPF3A,NOD1,PRKACA,ANAPC4,PLK1,ASNS,PTGES2,
HDGF,ZC3H12A,SEPT4,SYMPK,ATG4B,BCLAF1,JHDM1D,TNK2,WAC,
STK4,FUBP3,FGFR1,HSF4,PAIP1,ADCY4,PAF1,TAB2,RNF8,SEC31A,
MDM2,RHBDD1,FKBP1A,PPM1F,TBP,INO80,CREB1,NPTN,DDX58,NF
1,ZEB1,NUB1,RGMB,EBF1,NPR1,RPS6KA5,NIPBL,PKD2,RXRB,LMNA,
biol MITF,RB1,MAPK8IP3,ZFPM2,TP53BP1,RNF168,SENP2,IL18,TPP1,NR1
ogic H3,GRB10,FLCN,NRP1,PTEN,RUNX2,IQGAP1,FBXW7,SMARCD3,HER
al_p PUD1,IKBKB,PXN,NCOR1,MEF2A,SMEK1,PIAS2,MAPK8,DDX41,TRIM
roce 28,CSK,CDK5RAP2,PTPRC,PSMC6,CDK6,WDR61,ZNF148,PSMC4,SG
ss
SM3,PHKG2,PAK1,NCK2,CTSH,TCF4,SEMA4D,CSF1R,C3,NFYC,SS18
,SMAD4,CHURC1,CHURC1FNTB,TGFB1I1,DDAH1,CD276,CDC14B,NR2C2,FHOD1,GLI3,TMED2,D
CAF6,ENG,SIRT7,TCF12,ARNT,NOX4,PHF1,PDIA5,MED6,MDFI,CIRBP
,CIZ1,ITGA5,HINFP,NCBP2,LPCAT1,MLX,PDGFRB,GLIS3,CARD14,TN
FRSF14,RUNX1,SMARCA4,NAA16,YIF1A,TLN1,GSK3A,IGF2,PSMA1,S
TAT6,CSNK1E,NTRK1,TFAM,TNFRSF10B,SMAD9,HBB,ZBTB16,PHF19
,PKD1,PDPK1,USF1,FOXC1,DDAH2,CDK5RAP3,PABPC1,SMARCAD1,
GATA2
biol KANK2,SIRT2,NOC2L,SIN3B,CBX5,SUPT5H,BCL6,TBX2,CUX1,EED,S
ogic MAD7,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,SUPT4H1,USP47,PCGF6
1.53
113
101
1
0
2
1.
5
9
E
0
2
1.15
921
312
1
1.
6
2
E
0
2
1.26
652
1.
6
00
45
89
2
G
O:
00
06
18
4
G
O:
00
09
89
6
GTP catabolic process
al_p ,IGBP1,PLK1,HDGF,TBX18,DR1,BCLAF1,ZNF540,FGFR1,HSF4,PAF1,
roce MDM2,PPM1F,YY1,PFDN5,CREB1,PTPRK,ZEB1,RPS6KA5,NIPBL,RB1
ss
,PRMT5,ZFPM2,CHMP1A,ZNF263,NR1H3,FLCN,VPS72,RUNX2,NCOR
1,MEF2A,SETD8,TRIM28,UBP1,ZNF148,TCF4,SEMA4D,SMAD4,CREB
ZF,ING4,GLI3,ENG,SIRT7,WWP1,PHF12,MDFI,HINFP,MLX,GLIS3,SMA
RCA4,PER3,NCOR2,PHF21A,PDCD4,STAT6,ZBTB16,BAZ2A,RRP8,LM
CD1,TSG101,CC2D1A,GATA2
RAB3GAP2,EIF2B4,RALGAPA2,SEPT5,RAB34,BCL6,GBP3,MCF2L,AR
HGEF12,ARHGEF25,RGL4,STARD13,RAB35,RANBP1,SIPA1L1,KRIT1,
biol MINK1,RHOF,EEF1A1,TBC1D2B,DNM1L,HERC2,TBC1D10B,SEPT4,EF
ogic TUD2,TBC1D14,TNK2,GIT2,MTG1,RAB18,PLEKHG4,FAM13A,RALGPS
al_p 2,PLEKHG5,SNX13,NF1,RTKN,RAB31,GNAI1,PAFAH1B1,ACAP2,RGS
roce 3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,DENND4C,MAP4K4,TBCD,ARH
ss
GAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,TBC1D22A,RAB5A,TMED
2,RASGRF2,ARHGEF7,ASAP1,RGS2,FARP1,RAP1B,DOCK8,RGL2,PS
D3,BNIP2,NTRK1,RAPGEF6,DENND6B
244
4
1.28
742
517
8
positive regulation of catabolic process
biol
ogic SUPT5H,SMAD7,ADAM8,CSNK2A1,PLK1,ZC3H12A,ATG4B,WAC,MDM
al_p 2,RHBDD1,NUB1,PTEN,SGSM3,PHKG2,ARNT,LPCAT1,GSK3A,CSNK1
roce E,PABPC1
ss
1.69
523
190
3
G
O:
00
04
65
9
prenyltransferase activity
mol
ecul
ar_f
unct
ion
FDPS,RABGGTA,FNTB,RABGGTB
3.85
907
51
G
O:
neurexin family protein binding
mol
ecul
CPE,SYTL4,SYTL2,NLGN2
3.85
907
2
E
0
2
1.
6
2
E
0
2
1.
6
3
E
0
2
1.
6
4
E
0
2
1.
6
00
42
04
3
G
O:
00
31
41
8
G
O:
00
34
31
4
G
O:
00
16
56
8
G
O:
00
48
74
5
ar_f
unct
ion
51
L-ascorbic acid binding
mol
ecul
ar_f
unct
ion
LEPRE1,PAM,ALKBH3,OGFOD3,PLOD2
3.21
589
591
7
Arp2/3 complex-mediated actin nucleation
biol
ogic
al_p ARPC4-TTLL3,ACTR3,WASH4P,ACTR2
roce
ss
3.84
932
357
chromatin modification
biol
ogic
al_p
roce
ss
smooth muscle tissue development
biol
ogic
al_p NF1,PKD2,MYLK,ENG,PDGFRB
roce
ss
SIRT2,NOC2L,SUPT5H,EED,HDAC6,EHMT1,LEF1,SUPT4H1,CHD6,PC
GF1,DR1,JHDM1D,WAC,HSF4,PAF1,RNF8,INO80,PHF15,RPS6KA5,NI
PBL,BRD9,RB1,PRMT5,USP3,RNF168,FLCN,VPS72,SMARCD3,NCOR
1,SETD8,MAPK8,WDR61,ING4,MSL1,SIRT7,PHF1,SMARCA4,SETD2,K
ANSL3,ATXN3,PHF21A,BAZ2A,RRP8,PHF19,UBR5,EYA2,SMARCAD1,
GATA2
1.36
720
160
6
3.20
776
964
1
4
E
0
2
1.
6
5
E
0
2
1.
6
6
E
0
2
1.
6
6
E
0
2
1.
6
7
E
0
2
G
O:
00
09
05
8
biosynthetic process
FZD6,OBFC1,PBX2,KANK2,ACADVL,EIF2B4,GTF3C2,RAI1,IGF1R,PTS
,TNRC6A,SIRT2,MYNN,TRNAU1AP,NOC2L,TARS,RAF1,ZNF131,RSC1
A1,SFSWAP,CDK13,TAZ,SIN3B,CBX5,SUPT5H,SUPT20H,ST3GAL1,P
WP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,SHMT2,EEF2K,PLD1
,VAPB,GPAA1,CUX1,PGS1,NUP98,EED,FMR1,SMPD4,SMAD7,MCF2L,
HDAC6,EHMT1,ZNF496,NARS,LANCL2,PNKP,LEF1,GLS,PAX8,SUPT4
H1,ZNF83,EMX2,RBPMS,XYLT1,ZSCAN31,XBP1,FDPS,PAM,HSD17B1
2,APITD1,MPDU1,UHMK1,USP47,ADAM8,POLR3E,GABPB1,PCGF6,E
EF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,PIGS,PL
K1,ZNF446,PNPO,ASNS,PTGES2,UPF1,ZNF621,HDGF,FDXR,PPP5C,
PIGG,PDXK,NPC1,CCNL1,CHD6,ZC3H12A,SLC11A2,FAM58A,CLN8,T
BX18,PIGN,GCDH,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1
D,ZNF710,GIGYF2,WAC,ZNF142,FUBP3,RARS,ZNF540,ALDH18A1,FG
biol FR1,HSF4,PAIP1,CAPRIN1,GTF3C1,NADSYN1,ADCY4,CELF1,PAF1,T
ogic AB2,SGK1,DPF2,CHKB,NADK,IDI1,RNF8,SEC31A,MDM2,PRKCH,PPM
al_p 1F,ZNF595,TBP,YY1,INO80,GPAT2,GMEB2,MCFD2,PFDN5,CREB1,SR
roce P9,FLII,RPRD1A,DDX58,RPL27,CCNL2,PTPRK,SERPINH1,NF1,ZEB1,
ss
EIF4B,IFITM3,ASCC2,RGMB,EBF1,RPL9,MED28,NPR1,ZNF3,RPS6KA
5,NIPBL,ADSL,ALG6,ST3GAL4,BRD9,GCNT2,ZNF837,PKD2,RXRB,LM
NA,RSL1D1,MITF,NOL8,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,RNF168,
ZNF865,SENP2,ISYNA1,EDEM2,GPCPD1,IL18,PUM2,STARD3,SUB1,C
HMP1A,PDE8A,ZNF558,GALNT2,ZNF263,ZNF180,BICD1,ZNF276,NR1
H3,GARS,GRB10,MRPS7,USP7,PLD6,FLCN,ZNF605,ZNF410,GMDS,R
PL24,UST,MTMR14,RPL37A,SAP30BP,MAST2,VPS72,PTEN,ALDH1A3,
RNASEK,RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCO
R1,PPP1R10,MEF2A,FECH,SETD8,SMEK1,NECAB3,PIAS2,SSBP1,MA
PK8,MYCBP2,USP15,DDX41,MAN1A2,PBX3,ZNF565,ABCA2,AFF4,TRI
M28,DMTF1,CDK5RAP2,PTPRC,OAZ1,IMPDH1,UBP1,WDR61,EBF4,F
ARSA,ZNF148,ZNF76,STAG2,SP110,PPA2,ST6GALNAC5,PHKG2,NCK
2,TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,C3,NFYC,HSD17B
4,ELOVL1,FUT4,PIWIL4,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHU
1.08
420
591
5
1.
6
7
E
0
2
RC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,DDAH1,INO80E,DTYMK,RPL
4,MTRR,MBOAT2,ZNF44,CREBZF,ING4,CD276,RBMS1,EIF3M,ZNF687
,NR2C2,FHOD1,DNTTIP2,MRPL49,FLNA,IRF9,MGAT5,ATP5A1,GLI3,T
HNSL2,MAPK12,CCDC59,DCAF6,AK5,B4GALT4,ENG,SIRT7,ZSCAN5A
,TCF12,ARNT,NOX4,ZNF692,EXT1,GAPDH,PHF1,MTRF1L,B3GAT3,ST
K36,WWP1,PHF12,TBCE,MED6,MDFI,CIRBP,ZNF554,NUBP1,CIZ1,RG
S2,HINFP,NCBP2,MAN2A2,LPCAT1,MLX,PDGFRB,TGS1,CDK11A,MA
N1B1,GLIS3,ELP6,BDP1,DBF4,CANX,RUNX1,MKNK2,SMARCA4,NAA1
6,LRPPRC,RPLP0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3,CH
TF8,GSK3A,SNRPE,POLG,ZNF383,MRPL3,POLR2J3,NCOR2,FPGS,SE
TD2,PCYT1A,PIGO,PPAP2A,PDIA3,IGF2,PTGIS,TROVE2,ATXN3,PSTK
,PHF21A,GPHN,PDCD4,SOX13,PGM2,CHD2,STAT6,CARS2,ZNF138,Z
NF705A,NTRK1,TFAM,PHKG1,BRWD1,SMAD9,HBB,LMF1,TGFBR3,ZB
TB16,BAZ2A,SIRT3,UCK1,SPCS3,EIF3I,RRP8,VARS,LARS,PHF19,LM
CD1,PKD1,PDPK1,TSG101,USF1,FOXC1,DDAH2,ACAN,CDK5RAP3,F
MOD,ALG9,PABPC1,PANK3,EYA2,SMARCAD1,CC2D1A,PLA2G16,GA
TA2,PABPN1
G
O:
00
03
20
8
G
O:
00
16
85
3
cardiac ventricle morphogenesis
biol
ogic
CPE,SMAD7,FKBP1A,ZFPM2,SMARCD3,MEF2A,GAA,GSK3A,TGFBR3
al_p
,FOXC1
roce
ss
2.13
851
309
4
isomerase activity
mol
ecul
ar_f
unct
ion
1.68
834
535
6
EIF2B4,PPIL2,ENOSF1,SPATA20,PTGES2,IDI1,FKBP1A,QSOX1,FKBP
10,TXNDC5,ISYNA1,P4HB,HSD17B4,RPUSD4,PDIA5,EBPL,PDIA3,PTG
IS,PGM2
1.
7
0
E
0
2
1.
7
0
E
0
2
G
O:
00
44
44
0
G
O:
00
31
66
9
G
O:
00
04
57
1
G
O:
00
08
31
8
G
O:
00
70
HLA-DPB1,PLD1,HGS,HLA-C,HLADQA1,VPS52,NPC1,SLC11A2,VAMP7,HLADMB,TPCN2,TAB2,SNX13,IFITM3,STARD3,CHMP1A,ATP11B,WASH4P
,HLAF,ABCA2,APPL2,LEPROT,RAB10,VPS45,ATP6V0A1,RAB5A,SUN2,MC
OLN1,STAM2,CD164,NTRK1,TSG101,CD63,SCAMP1
endosomal part
cell
ular
_co
mpo
nent
cellular response to nutrient levels
biol
ogic
TNRC6A,SUPT5H,HDAC6,ASNS,NPC1,ATG4B,TBC1D14,WAC,MDM2,
al_p
ATG12,CHMP1A,NRBP2,ATG3,RRP8,USF1
roce
ss
1.82
062
601
3
mannosyl-oligosaccharide 1,2-alphamannosidase activity
mol
ecul
ar_f
unct
ion
EDEM2,MAN1A2,MAN1B1
5.06
503
606
9
protein prenyltransferase activity
mol
ecul
ar_f
unct
ion
RABGGTA,FNTB,RABGGTB
5.06
503
606
9
histone H3-K27 methylation
biol
ogic
EHMT1,PHF1,PHF19
al_p
roce
1.45
942
682
3
5.05
223
718
5
1.
7
0
E
0
2
1.
7
1
E
0
2
1.
7
1
E
0
2
1.
7
1
E
0
2
1.
7
2
E
73
4
G
O:
00
72
20
5
G
O:
00
00
18
3
G
O:
00
97
10
5
G
O:
00
72
05
0
ss
metanephric collecting duct development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
5.05
223
718
5
chromatin silencing at rDNA
biol
ogic
al_p SIRT2,BAZ2A,RRP8
roce
ss
5.05
223
718
5
presynaptic membrane assembly
biol
ogic
al_p PTEN,PTPRD,NLGN2
roce
ss
5.05
223
718
5
S-shaped body morphogenesis
biol
ogic
al_p PAX8,PKD2,PDGFRB
roce
ss
5.05
223
718
5
0
2
1.
7
2
E
0
2
1.
7
2
E
0
2
1.
7
2
E
0
2
1.
7
2
E
0
2
G
O:
00
22
00
8
G
O:
00
51
49
3
G
O:
00
19
04
8
G
O:
00
60
03
8
neurogenesis
FZD6,EIF2B4,CLMN,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,CNT
F,CUX1,ARHGEF12,CD72,LEF1,EMX2,ITGA9,UHMK1,CD9,SIPA1L1,MI
NK1,PDLIM5,ACTR3,LHX4,VASP,CSNK2A1,JAG2,SLC11A2,CNP,CLN8
,GIGYF2,FGFR1,CAPRIN1,PRKCH,SSH2,CREB1,NPTN,DFNA5,NF1,ZE
biol
B1,RGMB,RPS6KA5,ITGA3,RB1,MAPK8IP3,BLOC1S5,PAFAH1B1,MTC
ogic
H1,USP33,HEXA,NRP1,PTEN,FYN,SMARCD3,SRGAP2,MEF2A,TCTN1
al_p
,CACNB1,MYCBP2,PBX3,RAB8A,CSK,CDK5RAP2,COL9A3,PTPRC,CD
roce
K6,FLOT1,RANBP9,PAK1,NCK2,RAB10,SEMA6A,TCF4,SEMA4D,ROB
ss
O3,SMAD4,NAV1,EZR,GLI3,TCF12,EXT1,NRBP2,TBCE,UNC5B,PTPRD
,ITGA5,FARP1,RUNX1,SMARCA4,KIF13B,TLN1,PSD3,ROBO2,CACNB
3,PMP22,CDK5RAP1,BNIP2,NTRK1,SEPT2,STK24,SSH1,CDK5RAP3,
WNK1,CLASP1,TENM4,GATA2
regulation of cytoskeleton organization
biol
ogic
al_p
roce
ss
HDAC6,ARPC4TTLL3,PAM,CAPZB,RANBP1,ACTR3,PPM1F,SSH2,NEXN,ARPC2,PLK2
,PHPT1,MEF2A,WASH4P,VILL,MYCBP2,CDK5RAP2,TBCD,PAK1,NCK2
,CSF1R,ACTR2,FHOD1,NOX4,PDGFRB,TWF1,CRIPAK,CLIC4,SENP6,
SSH1,CLASP1
1.48
630
465
2
virus-host interaction
biol
ogic
al_p
roce
ss
PSMB10,F11R,CDK13,CBX5,VAPB,NUP98,VRK2,HLAC,PSMB9,BCL2L11,FDPS,RAD23A,STAT2,MDM2,TBP,CREB1,DDX58,I
FITM3,RB1,BICD1,USP7,CUL4A,FYN,SRPK1,FBXW7,KPNB1,LTBR,SP
110,KLC1,THOC2,SLC25A6,WWP1,ITGA5,TNFRSF14,RPLP0,DYNC1I2
,TSG101,KPNA1,PABPN1
1.41
626
055
9
cardiac muscle cell proliferation
biol
ogic
al_p TBX2,FGFR1,RXRB,MEF2A,TGFBR3,FOXC1,TENM4
roce
ss
1.22
161
175
5
2.54
887
641
8
1.
7
2
E
0
2
1.
7
3
E
0
2
1.
7
4
E
0
2
1.
7
6
E
0
2
G
O:
19
01
06
9
G
O:
00
05
77
3
G
O:
00
05
74
0
G
O:
00
03
72
4
guanosine-containing compound catabolic
process
RAB3GAP2,EIF2B4,RALGAPA2,SEPT5,RAB34,BCL6,GBP3,MCF2L,AR
HGEF12,ARHGEF25,RGL4,STARD13,RAB35,RANBP1,SIPA1L1,KRIT1,
biol MINK1,RHOF,EEF1A1,TBC1D2B,DNM1L,HERC2,TBC1D10B,SEPT4,EF
ogic TUD2,TBC1D14,TNK2,GIT2,MTG1,RAB18,PLEKHG4,FAM13A,RALGPS
al_p 2,PLEKHG5,SNX13,NF1,RTKN,RAB31,GNAI1,PAFAH1B1,ACAP2,RGS
roce 3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,DENND4C,MAP4K4,TBCD,ARH
ss
GAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,TBC1D22A,RAB5A,TMED
2,RASGRF2,ARHGEF7,ASAP1,RGS2,FARP1,RAP1B,DOCK8,RGL2,PS
D3,BNIP2,NTRK1,RAPGEF6,DENND6B
vacuole
cell
ular
_co
mpo
nent
HLA-DPB1,USP4,ATP6V1D,HLADQA1,ADAM8,NPC1,SLC11A2,RAB24,VAMP7,HLADMB,TBC1D14,TPCN2,HPS4,RNASET2,SNAP23,IFITM3,TXNDC5,TPP
1,CCDC115,HEXA,LGMN,CTNS,ABCA2,CTSH,ATP6V0A1,HGSNAT,GU
SB,MCOLN1,GAA,VAMP4,PDGFRB,CD164,WDFY3,DPP7,CLIC4,CTBS,
PPT2,CCZ1B,ACAN,CD63,FMOD
1.40
275
412
9
mitochondrial envelope
cell
ular
_co
mpo
nent
SLC25A37,ACADVL,RAF1,TAZ,MARCH5,SHMT2,NLN,PGS1,SLC9B2,V
RK2,BCL2L13,BCL2L11,STARD13,TTC19,DNM1L,FDXR,HERC2,CNP,
GCDH,ALDH18A1,TIMM23,CPT1B,GPAT2,DHRS1,MTCH1,PLD6,SRGA
P2,FECH,ERAL1,COX7A2L,COX14,TIMM50,GRPEL2,DTYMK,GOLPH3,
BCS1L,ATP5A1,NDUFV1,NDUFS2,SLC25A6,SDHA,DIABLO,LETMD1,P
OLG,FPGS,SFXN3,ATXN3,SLC25A24,SLC25A46,LETM1,UQCRH,BCL2
L2
1.34
501
486
9
RNA helicase activity
mol
ecul
ar_f
unct
ion
DDX23,SKIV2L,DHX9,UPF1,G3BP1,DDX6
2.79
450
265
8
1.28
224
786
5
1.
7
6
E
0
2
1.
7
6
E
0
2
1.
7
6
E
0
2
1.
7
7
E
0
2
G
O:
00
16
62
0
oxidoreductase activity, acting on the
aldehyde or oxo group of donors, NAD or
NADP as acceptor
mol
ecul
ar_f
unct
ion
nuclear-transcribed mRNA poly(A) tail
shortening
biol
ogic
al_p PAIP1,EIF4B,PAN2,RQCD1,PARN,PABPC1
roce
ss
2.78
744
120
6
ATP-dependent helicase activity
mol
ecul
ar_f
unct
ion
DHX34,DDX23,DDX39A,SKIV2L,DHX9,UPF1,CHD6,DDX58,G3BP1,DD
X6,DDX41,SKIV2L2,DHX40,CHD2,DHX37
1.80
894
145
3
G
O:
00
70
03
5
purine NTP-dependent helicase activity
mol
ecul
ar_f
unct
ion
DHX34,DDX23,DDX39A,SKIV2L,DHX9,UPF1,CHD6,DDX58,G3BP1,DD
X6,DDX41,SKIV2L2,DHX40,CHD2,DHX37
1.80
894
145
3
G
O:
00
18
protein N-linked glycosylation via
asparagine
biol
ogic SEC31A,MCFD2,ALG6,ST3GAL4,EDEM2,MAN1A2,MGAT5,B4GALT4,M
al_p AN2A2,MAN1B1,CANX,PDIA3,ALG9
roce
G
O:
00
00
28
9
G
O:
00
08
02
6
ALDH18A1,ALDH6A1,ALDH1A3,ALDH16A1,ALDH3B1,GAPDH
2.79
450
265
8
1.90
374
154
8
1.
7
7
E
0
2
1.
7
9
E
0
2
1.
8
0
E
0
2
1.
8
0
E
0
2
1.
8
0
E
27
9
G
O:
00
48
66
6
G
O:
00
09
41
1
G
O:
00
10
94
8
G
O:
00
04
84
3
ss
0
2
neuron development
FZD6,CLMN,IGF1R,LAMB1,RAF1,COL9A1,BDNF,COL2A1,CNTF,ARHG
EF12,CD72,ITGA9,UHMK1,SIPA1L1,MINK1,PDLIM5,ACTR3,LHX4,VAS
biol P,CSNK2A1,SLC11A2,CNP,FGFR1,CAPRIN1,SSH2,CREB1,NPTN,RG
ogic MB,RPS6KA5,RB1,MAPK8IP3,BLOC1S5,PAFAH1B1,MTCH1,USP33,HE
al_p XA,NRP1,PTEN,FYN,SRGAP2,MEF2A,TCTN1,CACNB1,MYCBP2,PBX3
roce ,RAB8A,COL9A3,PTPRC,FLOT1,RANBP9,PAK1,NCK2,RAB10,SEMA6A
ss
,SEMA4D,ROBO3,EZR,GLI3,EXT1,TBCE,UNC5B,PTPRD,ITGA5,FARP1
,RUNX1,KIF13B,TLN1,ROBO2,CACNB3,PMP22,NTRK1,SEPT2,STK24,
SSH1,WNK1,CLASP1,GATA2
response to UV
biol
ogic
NOC2L,USP47,MDM2,RHBDD1,YY1,INO80,PTPRK,CRIP1,FBXW7,FEC
al_p
H,MAPK8,ERCC1,CIRBP,USF1
roce
ss
1.84
918
485
2
negative regulation of cell cycle process
biol
ogic
KANK2,BCL6,USP47,ANAPC4,PAF1,MDM2,PKD2,RB1,SLFN11,CHMP1
al_p
A,PTEN,FBXW7,CDK5RAP2,STAG2,SMARCA4
roce
ss
1.80
437
042
3
ubiquitin-specific protease activity
mol
ecul
ar_f
unct
ion
2.34
900
223
5
USP10,USP4,USP47,USP3,USP33,USP7,USP15,ATXN3
1.26
665
775
6
1.
8
1
E
0
2
1.
8
3
E
0
2
1.
8
4
E
0
2
1.
8
5
E
0
2
G
O:
00
48
84
4
G
O:
00
44
71
0
artery morphogenesis
biol
ogic
al_p TBX2,SMAD7,NF1,PKD2,MYLK,ENG,PDGFRB,FOXC1
roce
ss
single-organism metabolic process
CRBN,RAB3GAP2,DHX34,ACADVL,EIF2B4,PSMB10,CKB,IGF1R,GK5,
NPHP3,PTS,MYO1D,EPHX2,RALGAPA2,TARS,RAF1,SEPT5,LEPRE1,
SLC16A3,BDNF,TAZ,SIN3B,ATP2B1,PLCD1,RAB34,ST3GAL1,BCL6,C
MPK2,ENOSF1,GBP3,SHMT2,PLD1,VAPB,GPAA1,PGS1,NUP98,SLC9
B2,AMT,SMPD4,MCF2L,HDAC6,ARHGEF12,ATP6V1D,TYW1B,NARS,H
6PD,PNKP,GLS,PAX8,PSMB9,ARHGEF25,RGL4,XYLT1,STARD13,FDP
S,PAM,ABCC1,HSD17B12,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,
DDX39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,PRKACA,RPP14,DHX9,
PIGS,PNPO,PDE7B,ASNS,TBC1D2B,DNM1L,TXNL1,PTGES2,UPF1,FD
biol XR,PIGG,PDXK,NPC1,HERC2,CHD6,NUP210,TBC1D10B,SEPT4,SLC1
ogic 1A2,EFTUD2,CNP,CLN8,PIGN,GCDH,JHDM1D,SLC16A1,PLCB4,DHRS
al_p X,TBC1D14,TNK2,GIT2,MTG1,RARS,ALDH18A1,RAB18,HSF4,MMP16,
roce ERH,NADSYN1,PMS1,ADCY4,SNCAIP,PDE4D,PLEKHG4,CPT1B,CHK
ss
B,NADK,IDI1,CYP2R1,IDH3G,FAM13A,INO80,GPAT2,CREB1,RALGPS
2,NAGK,PLEKHG5,QSOX1,DDX58,ALDH6A1,SNX13,SERPINH1,NF1,A
CAA1,RTKN,NPR1,G3BP1,RAB31,ALKBH3,ADSL,ST3GAL4,GCNT2,PK
D2,GALT,RB1,GNAI1,DHRS1,TXNDC5,PAFAH1B1,ISYNA1,GPCPD1,IL
18,STARD3,TPP1,PDE8A,AACS,DDX6,ACAP2,ADAM15,RGS3,NR1H3,
GARS,CYTH2,GRB10,HEXA,PLD6,FLCN,PTGR2,TENC1,FMO2,GMDS,
ARHGAP9,UST,MTMR14,PTEN,ALDH1A3,IDH1,IQGAP1,FBXW7,LGMN
,SMARCD3,CTNS,SNX17,SRGAP2,NCOR1,ATP11B,OXCT1,FECH,CO
X7A2L,SMEK1,DDX41,RNF213,ABCA2,DENND4C,MAP4K4,CP,ITPA,O
AZ1,PSMC6,TBCD,IMPDH1,SKIV2L2,ALDH16A1,RARRES2,NUP37,DD
2.34
306
652
1
1.
8
7
E
0
2
1.10
292
331
5
1.
8
8
E
0
2
HD2,FARSA,PSMC4,ARHGAP29,SGSM3,OGFOD3,GOPC,PPA2,ST6G
ALNAC5,PHKG2,LEPR,RHEB,SEMA4D,GNB3,CSF1R,DGKZ,C3,ALDH3
B1,P4HB,HSD17B4,ELOVL1,GRPEL2,TBC1D22A,C1QTNF3,DDAH1,DT
YMK,MTRR,MBOAT2,SLC23A2,DLST,RAB5A,CA5B,HGSNAT,ATP5A1,
TMED2,THNSL2,NDUFV1,NDUFS2,RASGRF2,AK5,GUSB,B4GALT4,EN
G,NOX4,ETFA,EXT1,GAPDH,GAA,B3GAT3,SLC25A6,SDHA,ATP8B2,A
RHGEF7,PDIA5,ASAP1,REXO2,NUP85,IDH3B,PTGR1,RGS2,LPCAT1,
MLX,PDGFRB,EBPL,TGS1,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,
DOCK8,LONRF3,GSK3A,NCOR2,FPGS,SETD2,PCYT1A,PIGO,PPAP2A
,PDIA3,IGF2,PTGIS,MYO1E,D2HGDH,GPHN,PGM2,RGL2,CHD2,LONP
2,PSMA1,CARS2,ACIN1,PSD3,OXNAD1,BNIP2,NTRK1,PHKG1,HBB,L
MF1,ABHD4,SIRT3,PLOD2,UCK1,SPCS3,VARS,LARS,DHX37,UQCRH,
DDAH2,ACAN,RAPGEF6,FMOD,MTO1,ALG9,PANK3,SMARCAD1,DEN
ND6B,PLA2G16
G
O:
00
31
30
0
G
O:
00
18
19
6
G
O:
00
16
intrinsic to organelle membrane
cell
ular
_co
mpo
nent
HLA-DPB1,ST3GAL1,GPAA1,CUX1,DERL2,HLA-C,HLADQA1,MARCH6,PIGS,TIMM23,RHBDD1,QSOX1,EMC3,ST3GAL4,PKD2
,GALNT2,HLAF,TMEM66,EMC4,ST6GALNAC5,ELOVL1,PCSK7,EXT1,CANX,AMFR,A
LG9
1.53
513
300
5
peptidyl-asparagine modification
biol
ogic
SEC31A,MCFD2,ALG6,ST3GAL4,EDEM2,MAN1A2,MGAT5,B4GALT4,M
al_p
AN2A2,MAN1B1,CANX,PDIA3,ALG9
roce
ss
1.88
327
120
9
cytoplasmic membrane-bounded vesicle
cell
ular
_co
mpo
1.26
036
901
4
CADM1,SEPT5,BDNF,CPE,RAB34,HLADPB1,DPP4,HGS,IL15RA,SYTL4,HLA-C,YIPF1,RGL4,PAM,HLADQA1,AP3S2,ADAM8,RAB35,CD9,CNP,VAMP7,CAMK2D,TNK2,FLG,VT
I1A,FGFR1,HPS4,SEC31A,MDM2,SNAP23,MCFD2,SNX21,RAB31,GNA
1.
9
3
E
0
2
1.
9
6
E
0
2
1.
9
6
E
02
3
G
O:
00
31
97
5
G
O:
00
16
35
8
nent
envelope
I1,BLOC1S5,TPP1,SYTL2,EPN2,ADAM15,GARS,SNX17,GGNBP2,SRG
AP2,ITGB5,CLTCL1,HLAF,ABCA2,RAB8A,DENND4C,CLTB,FLOT1,AAK1,GOPC,RAB10,CTSH,A
TP6V0A1,P4HB,TMED3,CLK3,RAB5A,TMED2,VEZT,SCFD1,PDGFRB,V
PS51,CANX,PTPN23,CRCP,PDIA3,MYO1E,CORO7,DPP7,CLIC4,CTTN
BP2,SEC31B,ZDHHC8,PDPK1,CD63
SLC25A37,ACADVL,RAF1,SLC16A3,TAZ,CBX5,MARCH5,SHMT2,NLN,
PGS1,NUP98,SLC9B2,VRK2,IL15RA,BCL2L13,BCL2L11,STARD13,RA
NBP1,NUTF2,TTC19,DNM1L,FDXR,NPC1,SHISA5,HERC2,NUP210,CN
cell
P,GCDH,ALDH18A1,TIMM23,CPT1B,GPAT2,LMNA,DHRS1,PAFAH1B1,
ular
SENP2,MTCH1,SYNE1,PLD6,KPNB1,SRGAP2,ATP11B,FECH,ERAL1,C
_co
OX7A2L,OSBPL3,NUP37,COX14,PAK1,TIMM50,GRPEL2,DTYMK,GOL
mpo
PH3,CDC14B,SUN2,BCS1L,ATP5A1,NDUFV1,NDUFS2,SLC25A6,SDH
nent
A,NUP85,DIABLO,LETMD1,LMNB1,LRPPRC,POLG,FPGS,SFXN3,WDF
Y3,ATXN3,SLC25A24,BNIP2,SLC25A46,LETM1,UQCRH,KPNA1,BCL2L
2
0
2
1.26
036
901
4
dendrite development
biol
ogic
BDNF,SIPA1L1,MINK1,PDLIM5,ACTR3,SLC11A2,CAPRIN1,NRP1,PTE
al_p
N,FYN,SRGAP2,MEF2A,PAK1,SEMA4D,PTPRD,FARP1
roce
ss
1.75
253
756
G
O:
00
51
02
8
mRNA transport
biol
ogic
NUP98,FMR1,DDX39A,UPF3A,UPF1,NUP210,FYTTD1,SENP2,NUP37,
al_p
SRSF10,THOC2,NUP85,NCBP2,LRPPRC,PABPN1
roce
ss
1.78
840
254
3
G
O:
regulation of chromosome organization
biol
ogic
1.78
840
NOC2L,RPS6KA5,NIPBL,RB1,FLCN,NCOR1,MAPK8,WDR61,ACD,ERC
C1,PHF1,PHF19,SENP6,UBR5,GATA2
1.
9
6
E
0
2
1.
9
7
E
0
2
1.
9
8
E
0
2
1.
9
00
33
04
4
G
O:
00
06
16
3
G
O:
00
04
00
4
G
O:
00
00
32
al_p
roce
ss
254
3
purine nucleotide metabolic process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,R
GL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DD
X39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DN
M1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,
biol GIT2,MTG1,RAB18,PMS1,ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,IN
ogic O80,RALGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB
al_p 31,ADSL,PKD2,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,
roce FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX41,RNF213,AB
ss
CA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,PSMC4
,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A
,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,ASAP1,RG
S2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,PANK3,DENND6B
ATP-dependent RNA helicase activity
mol
ecul
ar_f
unct
ion
DDX23,SKIV2L,DHX9,UPF1,G3BP1
3.06
971
882
9
lytic vacuole
cell
ular
_co
mpo
nent
HLA-DPB1,USP4,HLA-DQA1,ADAM8,NPC1,SLC11A2,VAMP7,HLADMB,TPCN2,HPS4,RNASET2,SNAP23,IFITM3,TXNDC5,TPP1,CCDC11
5,HEXA,LGMN,CTNS,ABCA2,CTSH,HGSNAT,GUSB,MCOLN1,GAA,VA
MP4,PDGFRB,CD164,DPP7,CTBS,PPT2,CCZ1B,ACAN,CD63,FMOD
1.43
206
570
8
1.19
329
030
7
8
E
0
2
1.
9
9
E
0
2
2.
0
1
E
0
2
2.
0
3
E
-
3
G
O:
00
05
76
4
lysosome
cell
ular
_co
mpo
nent
respiratory system process
biol
ogic
al_p GLS,JAG2,PBX3,GAA,NLGN2
roce
ss
3.06
196
193
mitochondrial respiratory chain complex
assembly
biol
ogic
al_p TAZ,TTC19,COX14,BCS1L,TFAM
roce
ss
3.06
196
193
G
O:
00
10
56
4
regulation of cell cycle process
biol
ogic
al_p
roce
ss
KANK2,PSMB10,SIRT2,CDK13,BCL6,LEF1,PSMB9,USP47,RANBP1,PT
PN6,CSNK2A1,PRKACA,ANAPC4,PLK1,WAC,PAF1,MDM2,INO80,PKD
2,CASP2,RB1,PRMT5,SLFN11,CHMP1A,PLK2,FLCN,CUL4A,CHFR,PT
EN,FBXW7,CDK5RAP2,PTPRC,PSMC6,PSMC4,STAG2,DGKZ,CDC14B
,HINFP,PDGFRB,DBF4,SMARCA4,IGF2,PSMA1,RRP8,SENP6
1.36
546
950
9
G
O:
magnesium ion binding
mol
ecul
EPHX2,PDXK,STK4,IDI1,IDH3G,RPS6KA5,STK38L,MAST2,PTEN,IDH1,
SRPK1,ATP11B,PPA2,MAPK12,STK36,ATP8B2,IDH3B,ENO4,SIK3,PG
1.61
160
G
O:
00
03
01
6
G
O:
00
33
10
8
HLA-DPB1,USP4,HLA-DQA1,ADAM8,NPC1,SLC11A2,VAMP7,HLADMB,TPCN2,HPS4,RNASET2,SNAP23,IFITM3,TXNDC5,TPP1,CCDC11
5,HEXA,LGMN,CTNS,ABCA2,CTSH,HGSNAT,GUSB,MCOLN1,GAA,VA
MP4,PDGFRB,CD164,DPP7,CTBS,PPT2,CCZ1B,ACAN,CD63,FMOD
1.43
206
570
8
0
2
2.
0
3
E
0
2
2.
0
3
E
0
2
2.
0
3
E
0
2
2.
0
3
E
0
2
2.
0
00
00
28
7
G
O:
00
42
82
6
G
O:
00
45
73
2
G
O:
00
05
51
8
G
O:
00
30
33
2
ar_f
unct
ion
M2,EYA2
238
5
histone deacetylase binding
mol
ecul
ar_f
unct
ion
positive regulation of protein catabolic
process
biol
ogic
SMAD7,ADAM8,CSNK2A1,PLK1,MDM2,RHBDD1,NUB1,PTEN,SGSM3,
al_p
LPCAT1,GSK3A,CSNK1E
roce
ss
1.92
466
178
5
collagen binding
mol
ecul
ar_f
unct
ion
SMAD7,HSD17B12,COL14A1,SERPINH1,ABI3BP,PAK1,SMAD4,ITGA1
1
2.29
902
346
4
cyclin binding
mol
ecul
ar_f
unct
ion
CDK14,CDK13,CDK6,CIZ1
3.60
180
342
7
SIRT2,CBX5,HDAC6,NIPBL,NCOR1,MEF2A,MAPK8,GLI3,NCOR2,USF1
2.07
796
351
5
3
E
0
2
2.
0
5
E
0
2
2.
0
8
E
0
2
2.
0
9
E
0
2
2.
1
1
E
0
2
G
O:
00
16
86
4
intramolecular oxidoreductase activity,
transposing S-S bonds
mol
ecul
ar_f
unct
ion
FMN binding
mol
ecul
ar_f
unct
ion
protein disulfide isomerase activity
mol
ecul
ar_f
unct
ion
G
O:
00
07
40
5
neuroblast proliferation
biol
ogic
al_p BDNF,LEF1,FGFR1,NF1,PAFAH1B1,SMARCD3,RAB10,GLI3
roce
ss
2.29
321
404
1
G
O:
pyridine-containing compound metabolic
process
biol
ogic
2.16
524
G
O:
00
10
18
1
G
O:
00
03
75
6
QSOX1,P4HB,PDIA5,PDIA3
3.60
180
342
7
TYW1B,PNPO,MTRR,NDUFV1
3.60
180
342
7
QSOX1,P4HB,PDIA5,PDIA3
3.60
180
342
7
H6PD,PNPO,FDXR,PDXK,NADSYN1,NADK,FMO2,IDH1,IDH3B
2.
1
1
E
0
2
2.
1
1
E
0
2
2.
1
1
E
0
2
2.
1
2
E
0
2
2.
1
00
72
52
4
G
O:
00
60
34
7
G
O:
00
33
52
2
G
O:
19
01
06
8
G
O:
00
30
al_p
roce
ss
450
8
heart trabecula formation
biol
ogic
al_p ADAMTS1,FKBP1A,SMARCA4,TGFBR3
roce
ss
3.59
270
199
8
histone H2A ubiquitination
biol
ogic
al_p PCGF1,RNF8,RNF168,UBR5
roce
ss
3.59
270
199
8
guanosine-containing compound metabolic
process
ER to Golgi transport vesicle
RAB3GAP2,EIF2B4,RALGAPA2,SEPT5,RAB34,BCL6,GBP3,MCF2L,AR
HGEF12,ARHGEF25,RGL4,STARD13,RAB35,RANBP1,SIPA1L1,KRIT1,
biol MINK1,RHOF,EEF1A1,TBC1D2B,DNM1L,HERC2,TBC1D10B,SEPT4,EF
ogic TUD2,TBC1D14,TNK2,GIT2,MTG1,RAB18,PLEKHG4,FAM13A,RALGPS
al_p 2,PLEKHG5,SNX13,NF1,RTKN,RAB31,GNAI1,PAFAH1B1,ACAP2,RGS
roce 3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,DENND4C,MAP4K4,TBCD,IMPD
ss
H1,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,TBC1D22A,RAB5
A,TMED2,RASGRF2,ARHGEF7,ASAP1,RGS2,FARP1,RAP1B,DOCK8,R
GL2,PSD3,BNIP2,NTRK1,RAPGEF6,DENND6B
cell
ular
HLA-DPB1,HLA-C,HLA-DQA1,SEC31A,MCFD2,HLA-F,SEC31B
_co
mpo
3
E
0
2
2.
1
3
E
0
2
2.
1
3
E
0
2
1.26
635
710
1
2.
1
8
E
0
2
2.44
883
236
2.
1
8
E
13
4
G
O:
00
09
29
5
G
O:
00
31
05
6
G
O:
00
05
75
9
G
O:
00
00
28
0
nent
nucleoid
cell
ular
_co ACADVL,SHMT2,SSBP1,LRPPRC,POLG,LONP2,TFAM
mpo
nent
2.44
883
236
regulation of histone modification
biol
ogic
NOC2L,RPS6KA5,NIPBL,FLCN,NCOR1,MAPK8,WDR61,PHF1,PHF19,U
al_p
BR5,GATA2
roce
ss
1.97
598
609
9
mitochondrial matrix
cell
ular
_co
mpo
nent
ACADVL,SHMT2,GLS,FDXR,GCDH,IDH3G,ALDH6A1,GARS,OXCT1,FE
CH,ERAL1,SSBP1,PPA2,GRPEL2,DTYMK,DLST,MRPL49,CA5B,ATP5A
1,ETFA,IDH3B,LRPPRC,POLG,MRPL3,FPGS,D2HGDH,ATXN3,CARS2,
TFAM,SIRT3
1.46
783
158
5
nuclear division
biol
ogic
al_p
roce
ss
SIRT2,CDK13,NUP98,APITD1,RANBP1,ANAPC4,PLK1,PPP5C,RNF8,A
NAPC16,INO80,NEK3,NUMA1,NIPBL,RB1,PRMT5,PAFAH1B1,CHMP1A
,CHFR,PTEN,SETD8,CLTCL1,DSN1,NUP37,STAG2,CENPT,CDCA3,FL
NA,NUP85,HAUS5,PDGFRB,NCAPD3,CDK11A,IGF2,MAU2,SEPT2,CLA
SP1,GORASP1
1.39
879
790
9
0
2
2.
1
8
E
0
2
2.
2
0
E
0
2
2.
2
3
E
0
2
2.
2
3
E
0
2
G
O:
00
07
06
7
G
O:
00
51
22
3
G
O:
00
16
79
0
G
O:
00
07
42
0
G
O:
00
80
mitosis
biol
ogic
al_p
roce
ss
SIRT2,CDK13,NUP98,APITD1,RANBP1,ANAPC4,PLK1,PPP5C,RNF8,A
1.39
NAPC16,INO80,NEK3,NUMA1,NIPBL,RB1,PRMT5,PAFAH1B1,CHMP1A
879
,CHFR,PTEN,SETD8,CLTCL1,DSN1,NUP37,STAG2,CENPT,CDCA3,FL
790
NA,NUP85,HAUS5,PDGFRB,NCAPD3,CDK11A,IGF2,MAU2,SEPT2,CLA
9
SP1,GORASP1
regulation of protein transport
biol
ogic
al_p
roce
ss
CADM1,NLRP1,SYTL4,RBPMS,PAM,UHMK1,ADAM8,PRKACA,DNM1L,
VAMP7,DISP1,MDM2,DDX58,RHBDF1,NF1,PKD2,GCC2,NR1H3,RAB8
A,CSK,GOPC,CSF1R,SMAD4,C1QTNF3,FLNA,GLI3,VAMP4,MDFI,RHB
DF2,PKD1,KPNA1,UBR5
1.44
672
563
7
thiolester hydrolase activity
mol
ecul
ar_f
unct
ion
USP10,USP4,USP47,USP20,USP24,USP3,USP33,PAN2,USP7,USP15,
USP54,USP40,ATXN3,PPT2,EGFL8
1.76
175
167
6
brain development
biol
ogic
al_p
roce
ss
FZD6,CADM1,CKB,IGF1R,LEF1,EMX2,BCL2L11,CD9,SEPT4,CNP,JHD
M1D,FGFR1,RAB18,SHARPIN,CREB1,NF1,ZEB1,NIPBL,CASP2,MAPK
8IP3,PAFAH1B1,PTEN,FYN,ALDH1A3,CTNS,SRGAP2,NCOR1,MEF2A,
OXCT1,TCTN1,CSK,CDK5RAP2,PTPRS,CDK6,NR2C2,GLI3,EXT1,STK
36,EPOR,SMARCA4,NCOR2,FPGS,SETD2,ROBO2,CDK5RAP1,SMAD9
,CTTNBP2,FOXC1,CDK5RAP3,C2CD3,GATA2
1.32
902
177
4
regulation of cellular response to stress
biol
ogic
al_p
roce
IGF1R,SUPT5H,XBP1,MINK1,IGBP1,NOD1,NPC1,BCLAF1,TBC1D14,W
AC,RNF8,MDM2,MAPK8IP3,RNF168,PAFAH1B1,FBXW7,LTBR,NCOR1,
FECH,SETD8,TRIM28,MAP4K4,CDK6,PAK1,NRBP2,MDFI,PDCD4,NSM
CE4A,SPRED1,STK24,UBR5
1.45
523
208
1
2.
2
3
E
0
2
2.
2
3
E
0
2
2.
2
4
E
0
2
2.
2
5
E
0
2
2.
2
5
E
13
5
G
O:
00
09
26
7
G
O:
00
00
08
7
G
O:
00
46
03
9
G
O:
00
14
85
5
ss
0
2
2.
2
7
E
0
2
2.
2
8
E
0
2
cellular response to starvation
biol
ogic
TNRC6A,SUPT5H,HDAC6,ASNS,NPC1,ATG4B,TBC1D14,WAC,ATG12,
al_p
NRBP2,ATG3,RRP8
roce
ss
1.90
201
870
5
M phase of mitotic cell cycle
biol
ogic
al_p
roce
ss
1.39
003
351
1
GTP metabolic process
RAB3GAP2,EIF2B4,RALGAPA2,SEPT5,RAB34,BCL6,GBP3,MCF2L,AR
HGEF12,ARHGEF25,RGL4,STARD13,RAB35,RANBP1,SIPA1L1,KRIT1,
biol MINK1,RHOF,EEF1A1,TBC1D2B,DNM1L,HERC2,TBC1D10B,SEPT4,EF
ogic TUD2,TBC1D14,TNK2,GIT2,MTG1,RAB18,PLEKHG4,FAM13A,RALGPS
al_p 2,PLEKHG5,SNX13,NF1,RTKN,RAB31,GNAI1,PAFAH1B1,ACAP2,RGS
roce 3,CYTH2,ARHGAP9,IQGAP1,SRGAP2,DENND4C,MAP4K4,TBCD,ARH
ss
GAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,TBC1D22A,RAB5A,TMED
2,RASGRF2,ARHGEF7,ASAP1,RGS2,FARP1,RAP1B,DOCK8,RGL2,PS
D3,BNIP2,NTRK1,RAPGEF6,DENND6B
1.26
528
691
4
2.
3
0
E
0
2
striated muscle cell proliferation
biol
ogic
al_p TBX2,FGFR1,RXRB,MEF2A,TGFBR3,FOXC1,TENM4
roce
ss
2.41
816
480
7
2.
3
1
E
0
SIRT2,CDK13,NUP98,APITD1,RANBP1,ANAPC4,PLK1,PPP5C,RNF8,A
NAPC16,INO80,NEK3,NUMA1,NIPBL,RB1,PRMT5,PAFAH1B1,CHMP1A
,CHFR,PTEN,SETD8,CLTCL1,DSN1,NUP37,STAG2,CENPT,CDCA3,FL
NA,SIRT7,NUP85,HAUS5,PDGFRB,NCAPD3,CDK11A,IGF2,MAU2,SEP
T2,CLASP1,GORASP1
2
G
O:
00
01
65
5
G
O:
00
51
72
6
G
O:
00
45
85
9
G
O:
00
07
26
4
urogenital system development
regulation of cell cycle
regulation of protein kinase activity
small GTPase mediated signal transduction
biol
ogic
al_p
roce
ss
IGF1R,NPHP3,BDNF,SMAD7,PAX8,EMX2,ADAMTS1,BCL2L11,TBX18,
FGFR1,NF1,CRIP1,NIPBL,PKD2,FLCN,TENC1,PTEN,IQGAP1,MEF2A,
CTSH,ACD,SMAD4,GLI3,PDGFRB,MYO1E,ROBO2,SMAD9,ZBTB16,PK
D1,FOXC1,GATA2
KANK2,PSMB10,SIRT2,PPP1R13B,CDK13,SART1,BCL6,LEF1,PSMB9,
BCL2L11,UHMK1,USP47,RANBP1,PTPN6,CSNK2A1,PRKACA,ANAPC4
biol
,PLK1,ASNS,CCNL1,FAM58A,WAC,FGFR1,PAF1,MDM2,INO80,CCNDB
ogic
P1,CCNL2,PTPRK,PKD2,CASP2,RB1,PRMT5,PAFAH1B1,SLFN11,CHM
al_p
P1A,PLK2,FLCN,CUL4A,CHFR,PTEN,FBXW7,CDK5RAP2,PTPRC,PSM
roce
C6,CDK6,PSMC4,SGSM3,STAG2,RHEB,DGKZ,ING4,CDC14B,MAPK12
ss
,HINFP,PDGFRB,DBF4,SMARCA4,IGF2,PDCD4,PSMA1,SON,CDK5RA
P1,RRP8,SENP6,PKD1,TSG101,FOXC1,CDK5RAP3,PLA2G16
ACADVL,IGF1R,RAF1,ZFP91,VAPB,XBP1,ADAM8,PTPN6,NOD1,PRKA
biol CA,PLK1,ASNS,HDGF,CCNL1,FAM58A,STK4,FGFR1,ADCY4,TAB2,SE
ogic C31A,PPM1F,CCNL2,NF1,PKD2,LMNA,RB1,MAPK8IP3,TPP1,SH3BP5,
al_p RGS3,PTEN,IQGAP1,FBXW7,HERPUD1,PXN,PRKRIP1,CSK,PTPRC,P
roce AK1,NCK2,CSF1R,AK5,NOX4,PDIA5,MDFI,RGS2,PDGFRB,CARD14,YI
ss
F1A,TLN1,GSK3A,IGF2,PDCD4,CRIPAK,CDK5RAP1,NTRK1,SPRED1,T
NFRSF10B,DUSP6,PKD1,PDPK1,CDK5RAP3,WNK1
RALGAPA2,RAF1,RAB34,BCL6,PLD1,MCF2L,ARHGEF12,ARHGEF25,
RGL4,STARD13,NISCH,RAB35,SIPA1L1,KRIT1,RHOF,TBC1D2B,RHOB
biol
TB1,TBC1D10B,RAB24,TBC1D14,TNK2,GIT2,RAB18,PLEKHG4,FAM13
ogic
A,RALGPS2,PLEKHG5,NF1,RTKN,G3BP1,RAB31,RB1,PAFAH1B1,ACA
al_p
P2,CYTH2,PLK2,FLCN,ARHGAP9,IQGAP1,SRGAP2,RAB8A,FLOT1,AR
roce
HGAP29,SGSM3,RAB10,RHEB,SEMA4D,DGKZ,TBC1D22A,RAB5A,MA
ss
PK12,RASGRF2,ARHGEF7,ASAP1,FARP1,RAP1B,DOCK8,ARL15,RGL
2,RABL3,PSD3,BNIP2,NTRK1,RAPGEF6
1.45
017
919
2
2.
3
5
E
0
2
1.26
588
493
2
2.
3
7
E
0
2
1.28
407
843
7
2.
3
7
E
0
2
1.28
120
130
7
2.
3
7
E
0
2
G
O:
00
09
06
0
G
O:
00
44
76
7
aerobic respiration
biol
ogic
al_p IDH3G,ADSL,IDH1,DLST,SDHA,IDH3B,SIRT3,UQCRH
roce
ss
single-organism developmental process
FZD6,PBX2,CRIP2,EIF2B4,CADM1,PSMB10,CKB,CLMN,IGF1R,LAMB1,
NPHP3,SIRT2,UTRN,RAF1,COL9A1,CDK13,BDNF,TAZ,SIN3B,CPE,PL
CD1,SART1,COL2A1,SUPT20H,MARCH5,LUC7L,BCL6,TBX2,PTPN22,
CNTF,CUX1,SMAD7,GLG1,ARHGEF12,EHMT1,RNH1,IL15RA,CD72,TT
LL3,LEF1,PAX8,EMX2,ITGA9,ADAMTS1,BCL2L11,XBP1,PAM,UHMK1,
ADAM8,CAPZB,PRPF40A,CD9,SIPA1L1,KRIT1,MINK1,PDLIM5,PTPN6,
ACTR3,LHX4,VASP,CSNK2A1,PRKACA,SDCCAG8,ASNS,JAG2,DNM1
L,RC3H1,ZC3H12A,SEPT4,POLM,SLC11A2,AAMP,CNP,CLN8,TBX18,J
HDM1D,BBS1,STK4,FGFR1,RAB18,HSF4,DISP1,CAPRIN1,CELF1,PDE
4D,PAF1,TAB2,SHARPIN,RNF8,KIAA0586,FKBP1A,PRKCH,YY1,SSH2,
biol THBS3,PFDN5,CREB1,NPTN,DFNA5,NF1,ZEB1,CRIP1,NUMA1,RGMB,
ogic COL18A1,MED28,NPR1,RPS6KA5,NIPBL,PKD2,CASP2,SLC12A6,RXR
al_p B,LMNA,MITF,RB1,MAPK8IP3,ZFPM2,BLOC1S5,PAFAH1B1,SENP2,IL1
roce 8,MTCH1,AACS,ARPC2,SYNE1,EPN2,ADAM15,USP33,HEXA,PLD6,FL
ss
CN,NRP1,TENC1,STX2,VPS72,PTEN,FYN,ALDH1A3,IDH1,SRPK1,RUN
X2,IQGAP1,FBXW7,SMARCD3,IFT172,CTNS,PXN,SRGAP2,NCOR1,M
EF2A,DYM,OXCT1,TTC7A,FECH,TCTN1,SSBP1,CACNB1,MYCBP2,MY
LK,MAN1A2,PBX3,RAB8A,AFF4,TRIM28,CSK,CDK5RAP2,COL9A3,PTP
RS,PTPRC,IMPDH1,UBP1,CDK6,RARRES2,WDR61,FLOT1,PSMC4,ST
AG2,GOPC,RANBP9,WDR35,PAK1,EVC,NCK2,RAB10,SEMA6A,CTSH,
TCF4,ACD,SEMA4D,CSF1R,C3,HSD17B4,ROBO3,SS18,SMAD4,TGFB
1I1,DDAH1,LMBR1,DTYMK,EZR,NR2C2,FLNA,ATP5A1,GLI3,TMED2,M
APK12,EPN1,VEZT,ENG,TCF12,ARNT,NOX4,EXT1,ERCC1,GAA,STK3
6,TBCE,ASAP1,MED6,UNC5B,MDFI,PTPRD,ITGA5,HINFP,LPCAT1,PD
GFRB,COL8A1,DZIP1,LGALS8,EPOR,CC2D2A,FARP1,CANX,RUNX1,
2.24
543
874
9
2.
3
8
E
0
2
1.10
670
797
4
2.
3
8
E
0
2
MKNK2,SMARCA4,KIF13B,PTPN23,TLN1,CD164,GSK3A,ANKRD6,ITG
A11,POLG,NCOR2,FPGS,SETD2,COL13A1,PTGIS,TROVE2,MYO1E,G
PHN,PDCD4,STAT6,TANC1,ACIN1,ROBO2,CACNB3,PMP22,CLIC4,CD
K5RAP1,BNIP2,NTRK1,BRWD1,SMAD9,DUSP6,CTTNBP2,TGFBR3,TM
EM237,ZBTB16,EGFL8,SEPT2,PKD1,PDPK1,FOXC1,ACAN,STK24,SS
H1,CDK5RAP3,C2CD3,MMP25,EYA2,WNK1,CLASP1,TENM4,GATA2,B
CL2L2
G
O:
00
06
91
4
G
O:
00
08
18
6
G
O:
00
04
11
5
G
O:
00
19
autophagy
biol
ogic
USP10,SUPT5H,SUPT20H,HDAC6,NPC1,ZC3H12A,RAB24,ATG4B,TB
al_p
C1D14,WAC,ATG12,NRBP2,VPS51,ATG4A,ATG16L2,ATG3
roce
ss
1.71
081
047
5
RNA-dependent ATPase activity
mol
ecul
ar_f
unct
ion
DDX23,SKIV2L,DHX9,UPF1,G3BP1
2.93
625
279
3
3,5-cyclic-AMP phosphodiesterase activity
mol
ecul
ar_f
unct
ion
PDE7B,PDE4D,PDE8A
4.50
225
428
3
growth factor binding
mol
ecul
ar_f
unct
IGF1R,COL2A1,FGFR1,RHBDF1,LTBP4,NRP1,IGFBP6,LIFR,FIBP,ENG,
PDGFRB,RHBDF2,NTRK1,TGFBR3
1.78
391
207
4
2.
4
1
E
0
2
2.
4
2
E
0
2
2.
4
2
E
0
2
2.
4
3
E
83
8
G
O:
00
31
65
7
G
O:
00
33
52
3
G
O:
00
06
01
3
G
O:
00
06
62
1
ion
regulation of cyclin-dependent protein
kinase activity involved in G1/S
biol
ogic
al_p PKD2,PTEN,PKD1
roce
ss
4.49
087
749
8
histone H2B ubiquitination
biol
ogic
al_p WAC,PAF1,RNF8
roce
ss
4.49
087
749
8
mannose metabolic process
biol
ogic
al_p SPATA20,MAN2C1,MAN2A2
roce
ss
4.49
087
749
8
protein retention in ER lumen
biol
ogic
al_p GPAA1,OS9,PDIA3
roce
ss
4.49
087
749
8
0
2
2.
4
4
E
0
2
2.
4
4
E
0
2
2.
4
4
E
0
2
2.
4
4
E
0
2
G
O:
00
97
09
0
presynaptic membrane organization
biol
ogic
al_p PTEN,PTPRD,NLGN2
roce
ss
4.49
087
749
8
maintenance of protein localization in
endoplasmic reticulum
biol
ogic
al_p GPAA1,OS9,PDIA3
roce
ss
4.49
087
749
8
2-deoxyribonucleotide biosynthetic process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
4.49
087
749
8
G
O:
00
34
06
3
stress granule assembly
biol
ogic
al_p PUM2,BICD1,CIRBP
roce
ss
4.49
087
749
8
G
O:
00
50
positive regulation of dendrite
morphogenesis
biol
ogic
ACTR3,CAPRIN1,PTPRD
al_p
roce
4.49
087
749
8
G
O:
00
35
43
7
G
O:
00
09
26
5
2.
4
4
E
0
2
2.
4
4
E
0
2
2.
4
4
E
0
2
2.
4
4
E
0
2
2.
4
4
E
77
5
G
O:
00
06
51
5
G
O:
00
46
38
5
G
O:
00
72
59
5
G
O:
00
22
40
3
ss
misfolded or incompletely synthesized
protein catabolic process
biol
ogic
al_p HDAC6,ATXN3,LONP2
roce
ss
4.49
087
749
8
deoxyribose phosphate biosynthetic
process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
4.49
087
749
8
maintenance of protein localization in
organelle
biol
ogic
al_p GPAA1,SYNE1,OS9,SUN2,PDIA3
roce
ss
2.92
883
315
1
cell cycle phase
CDK14,KANK2,PSMB10,SIRT2,CDK13,BCL6,NUP98,PSMB9,STARD9,
CEP135,APITD1,USP47,RANBP1,PTPN6,PRKACA,ANAPC4,PLK1,SDC
biol
CAG8,PPP5C,CAMK2D,GIGYF2,PMS1,PAF1,RNF8,MDM2,ANAPC16,IN
ogic
O80,NEK3,NUMA1,NIPBL,PKD2,CASP2,RB1,PRMT5,PAFAH1B1,SLFN
al_p
11,CHMP1A,NTMT1,PLK2,PLD6,CUL4A,CHFR,PTEN,NCOR1,SETD8,C
roce
LTCL1,CDK5RAP2,PTPRC,PSMC6,DSN1,CDK6,NUP37,PSMC4,STAG2
ss
,DGKZ,PIWIL4,CENPT,CDCA3,FLNA,SUN2,SIRT7,NUP85,HAUS5,HINF
P,PDGFRB,NCAPD3,RAD51B,CDK11A,DBF4,SMARCA4,IGF2,DYNC1I
1.24
171
728
1
0
2
2.
4
4
E
0
2
2.
4
4
E
0
2
2.
4
4
E
0
2
2.
4
8
E
0
2
2,MAU2,PSMA1,CSNK1E,SEPT2,SENP6,PKD1,CLASP1,GORASP1
G
O:
00
15
62
9
actin cytoskeleton
cell
ular
_co
mpo
nent
MYO1D,TARS,SLC16A3,LANCL2,ARPC4TTLL3,ADAM8,CAPZB,PDLIM5,ACTR3,VASP,AFAP1,TLN2,DDX58,TPM
4,MED28,PKD2,ARPC2,STK38L,DAAM1,IQGAP1,VILL,MYLK,PAK1,AC
TR2,EZR,FHOD1,FLNA,RAB5A,ACTR10,MYO7B,TLN1,PHC3,TWF1,MY
O1E,CORO7,CLIC4,SEPT2
1.39
556
099
1
cellular response to abiotic stimulus
biol
ogic
NOC2L,USP47,MDM2,RHBDD1,YY1,INO80,PTPRK,CRIP1,NIPBL,PKD2
al_p
,CASP2,SLC12A6,IL18,FBXW7,LTBR,MAPK8,MYLK,NOX4,TNFRSF10B
roce
ss
1.62
012
669
2
ribonucleoprotein complex biogenesis
biol
ogic SFSWAP,SART1,CLNS1A,DDX23,RC3H1,MTG1,CELF1,SF3A2,PIH1D1
al_p ,NOL8,PRMT5,PUM2,NSA2,DDX6,BICD1,PTEN,ERAL1,SKIV2L2,SRSF
roce 10,CIRBP,NCBP2,TGS1,RPLP0,SDAD1,SNRPE,FTSJ3,RRP8
ss
1.48
473
909
1
G
O:
00
51
23
5
maintenance of location
biol
ogic GPAA1,CAMK2D,TPCN2,FKBP1A,TLN2,PKD2,RB1,SYNE1,BICD1,GCC
al_p 2,PTPRC,GOPC,OS9,EZR,FLNA,SUN2,GAA,MDFI,CIZ1,TLN1,TWF1,P
roce DIA3,PKD1,CLASP1
ss
1.52
520
367
9
G
O:
positive regulation of organelle organization
biol
ogic
1.51
038
G
O:
00
71
21
4
G
O:
00
22
61
3
MARCH5,ARPC4TTLL3,BCL2L11,RANBP1,ACTR3,PLK1,DNM1L,PPM1F,RPS6KA5,NIPB
2.
4
9
E
0
2
2.
5
1
E
0
2
2.
5
3
E
0
2
2.
5
3
E
0
2
2.
5
00
10
63
8
G
O:
00
44
43
7
G
O:
00
05
87
5
G
O:
00
02
20
0
G
O:
00
71
47
8
al_p L,RB1,ARPC2,PTEN,NCOR1,WASH4P,WDR61,PAK1,NCK2,ACTR2,FH
roce OD1,NOX4,PHF1,PDGFRB,IGF2,PHF19
ss
480
9
vacuolar part
cell
ular
_co
mpo
nent
HLA-DPB1,ATP6V1D,HLA-DQA1,NPC1,SLC11A2,VAMP7,HLADMB,TPCN2,RNASET2,IFITM3,TXNDC5,TPP1,HEXA,LGMN,CTNS,ABC
A2,ATP6V0A1,HGSNAT,GUSB,MCOLN1,GAA,PDGFRB,CD164,CCZ1B,
ACAN,CD63,FMOD
1.48
164
647
microtubule associated complex
cell
ular
HDAC6,DYNC1I1,STARD9,PAFAH1B1,DNALI1,PXN,KIFC2,RANBP9,FN
_co
TB,KLC1,DNHD1,ACTR10,HAUS5,CLIP2,KIF13B,DYNC1I2
mpo
nent
1.69
616
094
2
somatic diversification of immune receptors
biol
ogic
al_p BCL6,LEF1,POLM,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.09
058
090
4
cellular response to radiation
biol
ogic
NOC2L,USP47,MDM2,RHBDD1,YY1,INO80,PTPRK,CRIP1,NIPBL,FBX
al_p
W7,NOX4
roce
ss
1.92
466
178
5
4
E
0
2
2.
6
1
E
0
2
2.
6
2
E
0
2
2.
6
2
E
0
2
2.
6
2
E
0
2
G
O:
00
21
51
0
spinal cord development
biol
ogic
LHX4,CLN8,GIGYF2,NF1,PKD2,TCTN1,PBX3,PTPRS,GLI3,PKD1,GATA
al_p
2
roce
ss
1.92
466
178
5
regulation of dendrite morphogenesis
biol
ogic
al_p SIPA1L1,PDLIM5,ACTR3,CAPRIN1,PTEN,SEMA4D,PTPRD
roce
ss
2.35
771
068
6
nucleosome binding
mol
ecul
ar_f
unct
ion
NOC2L,RNF168,MUM1,HMGN2
3.37
669
071
2
G
O:
00
16
86
2
intramolecular oxidoreductase activity,
interconverting keto- and enol-groups
mol
ecul
ar_f
unct
ion
QSOX1,P4HB,PDIA5,PDIA3
3.37
669
071
2
G
O:
regulation of catalytic activity
biol
ogic
RAB3GAP2,ACADVL,EIF2B4,PSMB10,IGF1R,PTS,MYO1D,RALGAPA2,
RAF1,NLRP1,BCL6,ZFP91,VAPB,SMAD7,MCF2L,HDAC6,ARHGEF12,R
1.14
968
G
O:
00
48
81
4
G
O:
00
31
49
1
2.
6
2
E
0
2
2.
6
2
E
0
2
2.
6
5
E
0
2
2.
6
5
E
0
2
2.
6
00
50
79
0
G
O:
00
16
44
5
G
O:
00
70
93
3
al_p NH1,LEF1,PSMB9,ARHGEF25,RGL4,BCL2L13,BCL2L11,STARD13,XB
roce P1,USP47,ADAM8,DNAJC10,RANBP1,SIPA1L1,KRIT1,MINK1,PTPN6,C
ss
SNK2A1,IGBP1,NOD1,PRKACA,ANAPC4,PLK1,ASNS,TBC1D2B,HDGF,
CCNL1,HERC2,TBC1D10B,SLC11A2,FAM58A,CLN8,TBC1D14,TNK2,GI
T2,STK4,FGFR1,MMP16,ADCY4,TAB2,SGK1,PLEKHG4,SEC31A,MDM
2,FKBP1A,PPM1F,FAM13A,CREB1,RALGPS2,PLEKHG5,ZCCHC9,CCN
L2,SNX13,SERPINH1,NF1,RTKN,PKD2,LMNA,RB1,MAPK8IP3,PAFAH1
B1,MTCH1,TPP1,SYTL2,ACAP2,ANXA5,SH3BP5,BICD1,RGS3,NR1H3,
CYTH2,ARHGAP9,PTEN,IQGAP1,FBXW7,PHPT1,HERPUD1,PXN,SRG
AP2,NCOR1,PPP1R10,MEF2A,PRKRIP1,SSBP1,MAPK8,DENND4C,MA
P4K4,CSK,PTPRC,OAZ1,PSMC6,TBCD,PSMC4,ARHGAP29,SGSM3,U
BA2,GOPC,PAK1,NCK2,LEPR,MTMR9,CTSH,ACD,SEMA4D,CSF1R,D
GKZ,C3,GRPEL2,TBC1D22A,CDC14B,TMED2,RASGRF2,AK5,ENG,NO
X4,ARHGEF7,PDIA5,ASAP1,MDFI,RGS2,PDGFRB,CARD14,DIABLO,F
ARP1,DBF4,YIF1A,TLN1,DOCK8,GSK3A,IGF2,PDCD4,RGL2,CRIPAK,P
SMA1,PSD3,CDK5RAP1,BNIP2,NTRK1,SPRED1,TNFRSF10B,LMF1,D
USP6,CPAMD8,SEPT2,PKD1,PDPK1,CDK5RAP3,RAPGEF6,WNK1,DE
NND6B
299
8
somatic diversification of immunoglobulins
biol
ogic
al_p BCL6,POLM,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.19
961
346
8
histone H4 deacetylation
biol
ogic
al_p HDAC6,SIRT7,BAZ2A,SMARCAD1
roce
ss
3.36
815
812
3
6
E
0
2
2.
6
6
E
0
2
2.
6
7
E
0
2
G
O:
20
01
24
4
G
O:
00
09
21
4
G
O:
00
51
29
4
G
O:
00
06
40
3
G
O:
00
04
positive regulation of intrinsic apoptotic
signaling pathway
biol
ogic
al_p BCL2L11,DNM1L,SEPT4,BCLAF1
roce
ss
3.36
815
812
3
cyclic nucleotide catabolic process
biol
ogic
al_p PDE7B,CNP,PDE4D,PDE8A
roce
ss
3.36
815
812
3
establishment of spindle orientation
biol
ogic
al_p NUMA1,PAFAH1B1,CDK5RAP2,CLASP1
roce
ss
3.36
815
812
3
RNA localization
biol
ogic
NUP98,FMR1,DDX39A,UPF3A,UPF1,NUP210,FYTTD1,YY1,SENP2,BIC
al_p
D1,NUP37,SRSF10,THOC2,NUP85,NCBP2,LRPPRC,PABPN1
roce
ss
1.65
967
211
9
cysteine-type endopeptidase activity
mol
ecul
ar_f
unct
1.47
644
776
1
USP10,RAF1,NLRP1,CASP4,LEF1,BCL2L13,BCL2L11,USP47,CSNK2A
1,IGBP1,NOD1,SLC11A2,USP20,MDM2,PPM1F,CAPN10,CASP2,MTCH
1,USP33,USP7,LGMN,HERPUD1,USP15,CTSH,DIABLO,PDIA3,TNFRS
F10B
2.
6
7
E
0
2
2.
6
7
E
0
2
2.
6
7
E
0
2
2.
6
8
E
0
2
2.
6
9
E
19
7
G
O:
00
51
64
9
ion
establishment of localization in cell
G
O:
00
23
05
7
negative regulation of signaling
G
O:
00
viral reproduction
SLC25A37,RAB3GAP2,CADM1,BTN3A1,NOC2L,NLRP1,SEPT5,BDNF,
BCL6,CUX1,NUP98,HDAC6,DYNC1I1,HGS,DERL2,SYTL4,GLS,PAX8,R
BPMS,XBP1,COG4,NISCH,PAM,AP3S2,UHMK1,ADAM8,RAB35,CD9,R
ANBP1,DDX39A,KPNA6,UPF3A,PRKACA,NUTF2,DNM1L,UPF1,NPC1,
HERC2,CNP,VAMP7,CAMK2D,FYTTD1,BBS1,SLC38A2,TPCN2,VTI1A,
HPS4,DISP1,SNCAIP,TIMM23,CPT1B,SEC31A,MDM2,SNAP23,FKBP1
A,CREB1,SRP9,DDX58,RPL27,LCP2,SNX13,AP4B1,RHBDF1,NF1,NUM
biol
A1,RPL9,RAB31,CAPN10,PKD2,LMNA,RB1,LTBP4,STX16,BLOC1S5,T
ogic
XNDC5,PAFAH1B1,STARD3,SYTL2,AACS,BICD1,GCC2,NR1H3,RPL24
al_p
,RPL37A,STX2,IQGAP1,PHPT1,SNX17,KPNB1,PPP1R10,OXCT1,WAS
roce
H4P,NECAB3,CACNB1,CLTCL1,ABCA2,RAB8A,CSK,CDK5RAP2,PTPR
ss
C,STX18,CLTB,GOPC,PAK1,RAB10,VPS45,ACD,CSF1R,ERC1,TIMM50
,OS9,SRSF10,SMAD4,GRPEL2,C1QTNF3,RPL4,FLNA,RAB5A,SUN2,H
GSNAT,ATP5A1,GLI3,TMED2,SDCBP2,THOC2,SCFD1,VTI1B,SLC25A6
,VAMP4,MDFI,STAM2,NCBP2,MLX,VPS51,TGS1,RAP1B,CANX,RUNX1
,LRPPRC,RPLP0,SDAD1,SNX27,KIF13B,RHBDF2,CRCP,TLN1,PDIA3,L
ONP2,ATG3,LMF1,SPCS3,PKD1,PDPK1,TSG101,KPNA1,CD63,SCAMP
1,UBR5,CLASP1,PABPN1
FZD6,KANK2,IGF1R,NPHP3,BCL6,PTPN22,SMAD7,GLG1,ARHGEF12,
HGS,LEF1,PTPN6,IGBP1,TBX18,STK4,MDM2,PFDN5,SNX13,NF1,G3B
biol
P1,RB1,PAFAH1B1,BICD1,RGS3,NR1H3,GRB10,PLK2,FLCN,PTEN,FY
ogic
N,RUNX2,FBXW7,PHPT1,RQCD1,NCOR1,PIAS2,USP15,CSK,PTPRC,L
al_p
EPROT,DGKZ,TGFB1I1,LRPAP1,GLI3,EPS15L1,EPN1,ENG,BICC1,AR
roce
HGEF7,UNC5B,MDFI,RGS2,STAM2,SMARCA4,ADRBK2,GSK3A,ANKR
ss
D6,PDCD4,SNX14,CRIPAK,CSNK1E,SPRED1,DUSP6,TGFBR3,PDPK1,
GATA2
biol PSMB10,F11R,CDK13,CBX5,SUPT5H,VAPB,NUP98,VRK2,ZNF496,LEF
ogic 1,HLAal_p C,SUPT4H1,PSMB9,BCL2L11,ZSCAN31,FDPS,RAD23A,RANBP1,STAT
0
2
1.15
335
537
7
2.
6
9
E
0
2
1.26
665
775
6
2.
7
1
E
0
2
1.26
665
775
2.
7
1
16
03
2
G
O:
00
30
67
0
G
O:
00
00
11
8
G
O:
00
00
93
2
G
O:
00
02
75
roce 2,ZNF446,NUP210,ZNF397,MDM2,TBP,CREB1,DDX58,RPL27,IFITM3,
ss
RPL9,RB1,MZF1,CALCOCO2,ZNF263,BICD1,USP7,CUL4A,RPL24,RPL
37A,FYN,SRPK1,FBXW7,KPNB1,LTBR,PSMC6,UBP1,NUP37,PSMC4,S
P110,KLC1,RPL4,THOC2,ZSCAN5A,SLC25A6,WWP1,NUP85,ITGA5,N
CBP2,TNFRSF14,SMARCA4,RPLP0,DYNC1I2,PSMA1,TSG101,USF1,K
PNA1,PABPN1
6
phagocytic vesicle membrane
cell
ular
_co RAB34,HLA-C,VAMP7,RAB31,HLA-F,RAB8A,RAB10,ATP6V0A1
mpo
nent
2.19
503
180
8
histone deacetylase complex
cell
ular
_co CBX5,HDAC6,CSNK2A1,NCOR1,APPL2,PHF12,NCOR2,PHF21A
mpo
nent
2.19
503
180
8
cytoplasmic mRNA processing body
cell
ular
_co XRN1,TNRC6A,UPF1,RC3H1,CAPRIN1,DDX6,PAN2,RQCD1
mpo
nent
2.19
503
180
8
immune response-activating signal
transduction
biol
ogic
al_p
roce
ss
1.46
214
616
2
BTN3A1,HLA-DPB1,PTPN22,HLADQA1,ADAM8,PTPN6,VASP,NOD1,RC3H1,TAB2,PRKCH,CREB1,DDX5
8,LCP2,RPS6KA5,NR1H3,PTEN,FYN,PHPT1,IKBKB,MEF2A,MAPK8,CS
K,PTPRC,PAK1,CACNB3,DUSP6,PDPK1
E
0
2
2.
7
2
E
0
2
2.
7
2
E
0
2
2.
7
2
E
0
2
2.
7
5
E
-
7
G
O:
00
10
92
7
cellular component assembly involved in
morphogenesis
biol
ogic
TTLL3,CD9,BBS1,PAFAH1B1,IFT172,MEF2A,RAB8A,WDR35,FLNA,ST
al_p
K36,PDGFRB,DZIP1,CC2D2A,PMP22,TMEM237,SEPT2,C2CD3,TENM4
roce
ss
1.62
756
634
1
heart morphogenesis
biol
ogic NPHP3,CPE,COL2A1,TBX2,SMAD7,ADAMTS1,FKBP1A,NIPBL,PKD2,Z
al_p FPM2,ADAM15,SMARCD3,MEF2A,TMED2,ENG,GAA,SMARCA4,GSK3
roce A,NCOR2,TGFBR3,FOXC1,C2CD3
ss
1.54
373
914
rDNA heterochromatin
cell
ular
_co BAZ2A,RRP8
mpo
nent
6.99
666
388
7
G
O:
00
32
59
3
insulin-responsive compartment
cell
ular
_co DENND4C,RAB10
mpo
nent
6.99
666
388
7
G
O:
blood microparticle
cell
ular
6.99
666
G
O:
00
03
00
7
G
O:
00
33
55
3
ANXA5,ENG
0
2
2.
7
6
E
0
2
2.
7
7
E
0
2
2.
7
8
E
0
2
2.
7
8
E
0
2
2.
7
00
72
56
2
G
O:
00
16
87
4
G
O:
00
31
32
5
_co
mpo
nent
388
7
PSMB10,PPIL2,TARS,MARCH5,ZFP91,SMAD7,NARS,TTLL3,PSMB9,R
NF220,MARCH6,ANAPC4,PLK1,ASNS,RC3H1,HERC2,MIB2,RARS,NA
DSYN1,RNF8,MDM2,KCMF1,UNKL,UBE2Q1,RNF168,RNF217,AACS,G
ARS,CHFR,PTEN,TMEM189,PIAS2,MYCBP2,RNF213,TRIM28,PSMC6,
RNF146,FARSA,PSMC4,UBA2,CDC14B,WWP1,UBA6,TRIM41,TTLL11,
FBXW2,FPGS,AMFR,PSMA1,CARS2,SHPRH,ATG3,VARS,LARS,UBR5
ligase activity
mol
ecul
ar_f
unct
ion
positive regulation of cellular metabolic
process
OBFC1,PBX2,ACADVL,PSMB10,IGF1R,RAF1,SUPT5H,MMS19,ZFP91,
CNTF,VAPB,SMAD7,MCF2L,HDAC6,ZNF496,LEF1,PAX8,SUPT4H1,PS
MB9,RBPMS,XBP1,APITD1,UHMK1,ADAM8,GABPB1,IGBP1,UPF3A,N
OD1,PRKACA,ANAPC4,PLK1,ASNS,PTGES2,HDGF,ZC3H12A,SEPT4,
SYMPK,ATG4B,BCLAF1,JHDM1D,TNK2,WAC,STK4,FUBP3,FGFR1,HS
F4,PAIP1,ADCY4,PAF1,TAB2,RNF8,SEC31A,MDM2,FKBP1A,TBP,INO8
0,CREB1,NPTN,DDX58,NF1,ZEB1,NUB1,RGMB,EBF1,NPR1,RPS6KA5,
biol NIPBL,PKD2,RXRB,LMNA,MITF,RB1,MAPK8IP3,ZFPM2,TP53BP1,RNF
ogic 168,SENP2,IL18,TPP1,NR1H3,GRB10,FLCN,NRP1,PTEN,RUNX2,IQGA
al_p P1,FBXW7,SMARCD3,HERPUD1,IKBKB,PXN,NCOR1,MEF2A,SMEK1,
roce PIAS2,DDX41,TRIM28,CSK,CDK5RAP2,PTPRC,PSMC6,WDR61,ZNF14
ss
8,PSMC4,PHKG2,PAK1,NCK2,TCF4,SEMA4D,CSF1R,C3,NFYC,SS18,S
MAD4,CHURC1,CHURC1FNTB,TGFB1I1,DDAH1,CD276,CDC14B,NR2C2,FHOD1,GLI3,DCAF6,E
NG,SIRT7,TCF12,ARNT,NOX4,PHF1,PDIA5,MED6,MDFI,CIRBP,CIZ1,IT
GA5,HINFP,NCBP2,MLX,PDGFRB,GLIS3,CARD14,TNFRSF14,RUNX1,
SMARCA4,NAA16,YIF1A,TLN1,GSK3A,IGF2,PSMA1,STAT6,CSNK1E,N
TRK1,TFAM,TNFRSF10B,SMAD9,HBB,ZBTB16,PHF19,PKD1,PDPK1,U
SF1,FOXC1,DDAH2,CDK5RAP3,PABPC1,SMARCAD1,GATA2
1.29
646
065
7
1.14
646
268
4
8
E
0
2
2.
8
0
E
0
2
2.
8
1
E
0
2
G
O:
00
01
57
8
G
O:
00
42
33
9
G
O:
00
16
57
4
G
O:
00
46
87
2
microtubule bundle formation
biol
ogic
al_p TTLL3,MARK4,PLK1,CDK5RAP2,NAV1,CLASP1
roce
ss
2.52
611
859
3
keratan sulfate metabolic process
biol
ogic
al_p ST3GAL1,ST3GAL4,HEXA,B4GALT4,ACAN,FMOD
roce
ss
2.52
611
859
3
histone ubiquitination
biol
ogic
al_p PCGF1,WAC,PAF1,RNF8,RNF168,UBR5
roce
ss
2.52
611
859
3
metal ion binding
mol
ecul
ar_f
unct
ion
RSPRY1,LPP,DHX34,CRIP2,RAI1,PTS,SIRT2,EPHX2,UTRN,MYNN,RA
F1,ZNF131,LEPRE1,COL9A1,RBM6,ATP2B1,CPE,PLCD1,COL2A1,CAL
ML4,MARCH5,BCL6,ZNF783,ENOSF1,ZFP91,EEF2K,NLN,PGS1,SMPD
4,SMAD7,USP4,HDAC6,EHMT1,ZNF496,HGS,TYW1B,SYTL4,DGKA,SU
PT4H1,ZNF83,ITGA9,ADAMTS1,ZSCAN31,CPM,FDPS,PAM,ADAM8,R
NF220,XAF1,PCGF6,MARCH6,PDLIM5,RNF24,LHX4,STAT2,ZNF446,L
MAN2,PDE7B,JAG2,UPF1,ZNF621,RC3H1,PPP5C,PDXK,HERC2,ZC3H
12A,MIB2,POLM,PCGF1,ZNF721,ZNF397,JHDM1D,ZNF710,PLCB4,DN
PEP,TNK2,USP20,GIT2,FLG,STK4,ZNF142,ZNF540,MAN2C1,MMP16,A
DCY4,PDE4D,SF3A2,TAB2,SHARPIN,DPF2,NADK,IDI1,RNF8,CYP2R1,
MDM2,KCMF1,ZCCHC14,ZFYVE26,PRKCH,PPM1F,ZNF595,IDH3G,YY
1.09
367
871
7
2.
8
3
E
0
2
2.
8
3
E
0
2
2.
8
3
E
0
2
2.
8
3
E
0
2
1,GMEB2,THBS3,MCFD2,DDX58,ZCCHC9,LIMCH1,ZEB1,NEK3,CRIP1,
REPS1,TPM4,COL18A1,EBF1,PHF15,FKBP10,UNKL,ZNF3,RPS6KA5,A
LKBH3,ZNF837,PKD2,RXRB,GALT,MDP1,PPP2R3C,ITGA3,ZZEF1,LTB
P4,RABGGTA,GNAI1,USP3,MZF1,ZFPM2,CPPED1,RNF168,ZNF865,E
DEM2,RNF217,TPP1,CHMP1A,PDE8A,STK38L,ACAP2,ZNF558,ANXA5
,GALNT2,ADAM15,USP33,ZNF263,ZNF180,ZNF276,NR1H3,NRP1,ZNF
605,CHFR,ZNF410,PTGR2,TENC1,RPL37A,MAST2,PTEN,FYN,IDH1,S
RPK1,IQGAP1,C1R,PXN,ADAMTS18,KPNB1,ATP11B,PPP1R10,PARN,
ZMYM5,TNS1,FECH,NECAB3,PIAS2,CLSTN2,MYCBP2,MYLK,DDX41,
MAN1A2,RNF213,ZNF565,ZFAND2B,TRIM28,CP,ITPA,SWAP70,IMPDH
1,RNF146,AGBL5,EBF4,DDHD2,ZNF148,ZNF76,ARHGAP29,OGFOD3,
UBA2,SP110,PPA2,PCDH7,RHEB,ZSWIM7,TRPM7,IKZF5,DGKZ,ZNF60
9,SMAD4,FNTB,CHURC1,CHURC1FNTB,ZNF114,TGFB1I1,DDAH1,LIMD2,MTRR,ZNF44,TANK,ING4,ZNF6
87,NR2C2,CA5B,C1S,GLI3,ADD3,NDUFV1,MAPK12,NDUFS2,EPS15L1
,B4GALT4,SIRT7,ZSCAN5A,ZNF692,PHF1,B3GAT3,STK36,ATP8B2,DE
F8,PHF12,ASAP1,CAPS2,RABGGTB,ZNF554,IDH3B,PTGR1,NUBP1,CI
Z1,ITGA5,HINFP,MAN2A2,LPCAT1,DZIP1,MAN1B1,GLIS3,NOB1,ENO4
,DBF4,CANX,RUNX1,MKNK2,TRIM41,MFI2,SUMF2,ZNF518B,ZNF90,Z
NF638,ZC4H2,PHC3,DNAJC21,LONRF3,SIK3,ITGA11,ZNF383,EFCAB2
,SETD2,PTGIS,WDFY3,AMFR,NUCB1,MOB1A,PHF21A,GPHN,PGM2,E
RI3,ZBED5,STAT6,CARS2,SLC25A24,ZNF138,ZNF705A,CDK5RAP1,B
NIP2,SHPRH,CACNA2D1,SMAD9,HBB,ZFC3H1,CACNA2D4,LIMS2,ZBT
B16,STAMBPL1,ZDHHC8,BAZ2A,SIRT3,PLOD2,EGFL8,PHF19,LMCD1,
LETM1,THAP6,ZC3H14,ACAN,STK24,MMP25,UBR5,EYA2,PHC2,ZC3H
15,GATA2
G
O:
00
00
79
2
heterochromatin
cell
ular
CBX5,EED,TRIM28,NCAPD3,SMARCA4,BAZ2A,RRP8,FOXC1,SMARC
_co
AD1
mpo
nent
2.06
458
934
4
2.
8
4
E
0
2
G
O:
00
48
73
8
G
O:
00
44
76
4
G
O:
00
10
81
0
G
O:
00
45
18
2
1.64
773
203
2
2.
8
5
E
0
2
1.26
305
929
6
2.
8
6
E
0
2
cardiac muscle tissue development
biol
ogic
TAZ,SIN3B,TBX2,SMAD7,FGFR1,FKBP1A,RXRB,LMNA,ZFPM2,PTEN,
al_p
MEF2A,GAA,PDGFRB,GSK3A,TGFBR3,FOXC1,TENM4
roce
ss
multi-organism cellular process
PSMB10,F11R,CDK13,CBX5,SUPT5H,VAPB,NUP98,VRK2,ZNF496,LEF
1,HLAbiol C,SUPT4H1,PSMB9,BCL2L11,ZSCAN31,FDPS,RAD23A,RANBP1,STAT
ogic 2,ZNF446,NUP210,ZNF397,MDM2,TBP,CREB1,DDX58,RPL27,IFITM3,
al_p RPL9,RB1,MZF1,CALCOCO2,ZNF263,BICD1,USP7,CUL4A,RPL24,RPL
roce 37A,FYN,SRPK1,FBXW7,KPNB1,LTBR,PSMC6,UBP1,NUP37,PSMC4,S
ss
P110,KLC1,RPL4,THOC2,ZSCAN5A,SLC25A6,WWP1,NUP85,ITGA5,N
CBP2,TNFRSF14,SMARCA4,RPLP0,DYNC1I2,PSMA1,TSG101,USF1,K
PNA1,PABPN1
regulation of cell-substrate adhesion
biol
ogic
UTRN,BCL6,HSD17B12,MINK1,PPM1F,NF1,PLEKHA2,ARPC2,PTEN,T
al_p
BCD,CDK6,ABI3BP,COL8A1,ATXN3
roce
ss
1.74
645
236
translation regulator activity
mol
ecul
ar_f
unct
ion
2.81
390
892
7
ZNF540,PAIP1,CELF1,CIRBP,PABPC1
2.
8
6
E
0
2
2.
8
7
E
0
2
G
O:
00
06
48
7
G
O:
00
51
22
0
G
O:
00
51
65
3
G
O:
00
05
54
3
G
O:
00
48
protein N-linked glycosylation
biol
ogic
SEC31A,MCFD2,ALG6,ST3GAL4,EDEM2,MAN1A2,MGAT5,B4GALT4,M
al_p
AN2A2,MAN1B1,CANX,PDIA3,ALG9
roce
ss
1.78
718
594
3
cytoplasmic sequestering of protein
biol
ogic
al_p PKD2,GOPC,FLNA,MDFI,PKD1
roce
ss
2.80
679
843
6
spindle localization
biol
ogic
al_p ACTR3,NUMA1,PAFAH1B1,CDK5RAP2,CLASP1
roce
ss
2.80
679
843
6
phospholipid binding
mol
ecul
ar_f
unct
ion
PLEKHA3,PLCD1,PLD1,GPAA1,MCF2L,ARHGEF12,LANCL2,SYTL4,DG
KA,ARHGEF25,NISCH,RAB35,CMIP,TBC1D2B,AFAP1,SGK1,PLEKHG4
,ZCCHC14,ZFYVE26,RALGPS2,PLEKHG5,SNX13,SNX21,RTKN,PLEK
HA2,SYTL2,ACAP2,ANXA5,CYTH2,GRB10,PXDC1,ARHGAP9,SNX17,S
H3BP2,OSBPL3,SWAP70,APPL2,RASGRF2,ARHGEF7,PHF12,ASAP1,
FARP1,SNX27,ADRBK2,TWF1,WDFY3,MYO1E,SNX14,PSD3
1.31
576
815
positive regulation of response to stimulus
biol
ogic
al_p
roce
CADM1,IGF1R,BTN3A1,RAF1,SUPT5H,HLADPB1,PTPN22,CNTF,HDAC6,LANCL2,BCL2L11,RBPMS,XBP1,HLADQA1,ADAM8,MINK1,PTPN6,VASP,CSNK2A1,NOD1,DNM1L,RC3H1,P
PP5C,SHISA5,SEPT4,MIB2,BCLAF1,WAC,FGFR1,C2,CFB,DISP1,TAB2
1.19
035
307
2
2.
8
9
E
0
2
2.
9
0
E
0
2
2.
9
0
E
0
2
2.
9
1
E
0
2
2.
9
2
E
58
4
G
O:
00
00
79
1
G
O:
00
72
52
1
ss
,SHARPIN,RNF8,FKBP1A,PRKCH,PPM1F,CREB1,NPTN,PLEKHG5,DD
X58,LCP2,RPS6KA5,PKD2,MAPK8IP3,RNF168,PAFAH1B1,IL18,NR1H3
,GRB10,PLK2,FLCN,PTEN,FYN,C1R,FBXW7,PHPT1,IKBKB,PXN,LTBR,
MEF2A,MAPK8,SH3BP2,MYLK,TRIM28,CSK,PTPRC,RNF146,RARRES
2,AAK1,PAK1,EVC,RHEB,SEMA4D,CSF1R,C3,SMAD4,C1QTNF3,TGFB
1I1,GOLPH3,NR2C2,APOL3,FLNA,C1S,ENG,ARNT,NOX4,SLC25A6,ST
K36,MDFI,ITGA5,PDGFRB,GSK3A,ANKRD6,IGF2,PTGIS,CSNK1E,CAC
NB3,NSMCE4A,BNIP2,NTRK1,SPRED1,TNFRSF10B,DUSP6,TGFBR3,
LMCD1,PDPK1,UBR5,CC2D1A
euchromatin
cell
ular
_co TBP,CREB1,TRIM28,SMARCA4
mpo
nent
purine-containing compound metabolic
process
CRBN,RAB3GAP2,DHX34,EIF2B4,MYO1D,RALGAPA2,RAF1,SEPT5,A
TP2B1,RAB34,BCL6,GBP3,MCF2L,ARHGEF12,ATP6V1D,ARHGEF25,R
GL4,STARD13,ABCC1,DDX23,DNAJC10,RAB35,RANBP1,SIPA1L1,DD
X39A,KRIT1,SKIV2L,MINK1,RHOF,EEF1A1,DHX9,PDE7B,TBC1D2B,DN
M1L,UPF1,HERC2,CHD6,TBC1D10B,SEPT4,EFTUD2,TBC1D14,TNK2,
biol GIT2,MTG1,RAB18,PMS1,ADCY4,PDE4D,PLEKHG4,NADK,FAM13A,IN
ogic O80,RALGPS2,PLEKHG5,DDX58,SNX13,NF1,RTKN,NPR1,G3BP1,RAB
al_p 31,ADSL,PKD2,GNAI1,PAFAH1B1,PDE8A,DDX6,ACAP2,RGS3,CYTH2,
roce FLCN,ARHGAP9,IQGAP1,CTNS,SRGAP2,ATP11B,DDX41,RNF213,AB
ss
CA2,DENND4C,MAP4K4,ITPA,PSMC6,TBCD,IMPDH1,SKIV2L2,PSMC4
,ARHGAP29,SGSM3,GOPC,RHEB,SEMA4D,GNB3,GRPEL2,TBC1D22A
,RAB5A,ATP5A1,TMED2,RASGRF2,AK5,ATP8B2,ARHGEF7,ASAP1,RG
S2,RAD51B,FARP1,RAP1B,SMARCA4,DHX40,DOCK8,LONRF3,GSK3A
,MYO1E,RGL2,CHD2,LONP2,ACIN1,PSD3,BNIP2,NTRK1,DHX37,RAPG
EF6,MTO1,PANK3,DENND6B
0
2
3.29
254
771
1
2.
9
2
E
0
2
1.17
521
218
5
2.
9
5
E
0
2
G
O:
00
34
39
9
nuclear periphery
cell
ular
NUP98,PRPF40A,YY1,NUMA1,LMNA,CHMP1A,SRPK1,TGFB1I1,LMNB
_co
1,NARF,ATXN3,CLIC4,SMARCAD1
mpo
nent
1.78
346
334
4
G
O:
00
16
44
7
somatic recombination of immunoglobulin
gene segments
biol
ogic
al_p BCL6,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.30
020
554
8
G
O:
00
02
38
1
immunoglobulin production involved in
immunoglobulin mediated immune
response
biol
ogic
al_p BCL6,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.30
020
554
8
1-acylglycerophosphocholine Oacyltransferase activity
mol
ecul
ar_f
unct
ion
TAZ,LPCAT1
6.75
338
142
5
transcription corepressor binding
mol
ecul
ar_f
unct
HDGF,PHF12
6.75
338
142
5
G
O:
00
47
18
4
G
O:
00
01
2.
9
6
E
0
2
2.
9
7
E
0
2
2.
9
7
E
0
2
2.
9
7
E
0
2
2.
9
7
E
22
2
G
O:
00
17
16
0
G
O:
00
01
22
1
G
O:
00
16
92
9
G
O:
00
43
04
7
ion
Ral GTPase binding
mol
ecul
ar_f
unct
ion
transcription cofactor binding
mol
ecul
ar_f
unct
ion
SUMO-specific protease activity
mol
ecul
ar_f
unct
ion
single-stranded telomeric DNA binding
mol
ecul
ar_f
unct
ion
PRKCH,FLNA
6.75
338
142
5
HDGF,PHF12
6.75
338
142
5
SENP2,SENP6
6.75
338
142
5
OBFC1,ACD
6.75
338
142
5
0
2
2.
9
7
E
0
2
2.
9
7
E
0
2
2.
9
7
E
0
2
2.
9
7
E
0
2
G
O:
00
03
83
6
G
O:
00
70
32
4
G
O:
00
08
47
4
G
O:
00
07
17
3
G
O:
00
90
beta-galactoside (CMP) alpha-2,3sialyltransferase activity
mol
ecul
ar_f
unct
ion
thyroid hormone binding
mol
ecul
ar_f
unct
ion
palmitoyl-(protein) hydrolase activity
mol
ecul
ar_f
unct
ion
epidermal growth factor receptor signaling
pathway
biol
ogic RAF1,HGS,PRKACA,ADCY4,MDM2,CREB1,RHBDF1,RPS6KA5,PTEN,
al_p FBXW7,PXN,CSK,NCK2,EPS15L1,EPN1,ARHGEF7,STAM2,GSK3A,PD
roce PK1
ss
1.58
993
799
6
regulation of pancreatic juice secretion
biol
ogic
NR1H3,WNK1
al_p
roce
6.73
631
624
7
ST3GAL1,ST3GAL4
6.75
338
142
5
ALDH1A3,CTSH
6.75
338
142
5
PPT2,EGFL8
6.75
338
142
5
2.
9
7
E
0
2
2.
9
7
E
0
2
2.
9
7
E
0
2
2.
9
8
E
0
2
2.
9
9
E
18
6
G
O:
00
71
87
7
G
O:
00
71
47
6
G
O:
00
72
21
8
G
O:
00
71
83
8
ss
regulation of adrenergic receptor signaling
pathway
biol
ogic
al_p RGS2,GSK3A
roce
ss
6.73
631
624
7
cellular hypotonic response
biol
ogic
al_p SLC12A6,MYLK
roce
ss
6.73
631
624
7
metanephric ascending thin limb
development
biol
ogic
al_p PKD2,PKD1
roce
ss
6.73
631
624
7
cell proliferation in bone marrow
biol
ogic
al_p LEF1,MEF2A
roce
ss
6.73
631
624
7
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
G
O:
00
16
92
6
protein desumoylation
biol
ogic
al_p SENP2,SENP6
roce
ss
6.73
631
624
7
metanephric comma-shaped body
morphogenesis
biol
ogic
al_p PAX8,PDGFRB
roce
ss
6.73
631
624
7
regulation of histone H3-K27 methylation
biol
ogic
al_p PHF1,PHF19
roce
ss
6.73
631
624
7
G
O:
00
09
13
8
pyrimidine nucleoside diphosphate
metabolic process
biol
ogic
al_p CMPK2,DTYMK
roce
ss
6.73
631
624
7
G
O:
00
71
regulation of cell proliferation in bone
marrow
biol
ogic
LEF1,MEF2A
al_p
roce
6.73
631
624
7
G
O:
00
72
27
8
G
O:
00
61
08
5
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
86
3
G
O:
00
71
86
4
G
O:
00
06
97
1
G
O:
00
90
14
1
G
O:
00
17
00
4
ss
positive regulation of cell proliferation in
bone marrow
biol
ogic
al_p LEF1,MEF2A
roce
ss
6.73
631
624
7
hypotonic response
biol
ogic
al_p SLC12A6,MYLK
roce
ss
6.73
631
624
7
positive regulation of mitochondrial fission
biol
ogic
al_p MARCH5,DNM1L
roce
ss
6.73
631
624
7
cytochrome complex assembly
biol
ogic
al_p TTC19,BCS1L
roce
ss
6.73
631
624
7
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
G
O:
19
00
12
0
regulation of receptor binding
biol
ogic
al_p LEF1,NRP1
roce
ss
6.73
631
624
7
nuclear matrix organization
biol
ogic
al_p SYNE1,SUN2
roce
ss
6.73
631
624
7
negative regulation of phospholipase
activity
biol
ogic
al_p BICD1,RGS2
roce
ss
6.73
631
624
7
G
O:
00
18
34
3
protein farnesylation
biol
ogic
al_p FNTB,CHURC1-FNTB
roce
ss
6.73
631
624
7
G
O:
20
00
positive regulation of glycogen (starch)
synthase activity
biol
ogic
GSK3A,IGF2
al_p
roce
6.73
631
624
7
G
O:
00
43
57
8
G
O:
00
10
51
9
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
2.
9
9
E
46
7
G
O:
00
72
02
1
G
O:
00
31
08
0
G
O:
00
22
40
2
G
O:
00
33
ss
ascending thin limb development
biol
ogic
al_p PKD2,PKD1
roce
ss
6.73
631
624
7
nuclear pore outer ring
cell
ular
_co NUP98,NUP37,NUP85
mpo
nent
4.19
799
833
2
cell cycle process
regulation of intracellular protein transport
CDK14,KANK2,PSMB10,SIRT2,CDK13,SART1,BCL6,NUP98,LEF1,PSM
B9,STARD9,CEP135,APITD1,UHMK1,USP47,RANBP1,PTPN6,ACTR3,
CSNK2A1,PRKACA,ANAPC4,PLK1,SDCCAG8,PPP5C,CAMK2D,GIGYF
biol 2,WAC,PMS1,PAF1,RNF8,MDM2,ANAPC16,INO80,NEK3,NUMA1,NIPB
ogic L,PKD2,CASP2,RB1,PRMT5,PAFAH1B1,SLFN11,CHMP1A,NTMT1,PLK
al_p 2,PLD6,FLCN,CUL4A,CHFR,PTEN,FBXW7,NCOR1,SETD8,CLTCL1,CD
roce K5RAP2,PTPRC,PSMC6,DSN1,CDK6,NUP37,PSMC4,SGSM3,STAG2,R
ss
HEB,DGKZ,PIWIL4,CENPT,ING4,CDCA3,CDC14B,FLNA,SUN2,MAPK1
2,SIRT7,NUP85,HAUS5,HINFP,PDGFRB,NCAPD3,RAD51B,CDK11A,D
BF4,SMARCA4,IGF2,DYNC1I2,MAU2,PSMA1,CSNK1E,BNIP2,RRP8,SE
PT2,SENP6,PKD1,TSG101,SMARCAD1,CLASP1,GORASP1
biol
RBPMS,UHMK1,PRKACA,VAMP7,MDM2,DDX58,NF1,PKD2,GCC2,CSK
ogic
,GOPC,SMAD4,C1QTNF3,FLNA,GLI3,VAMP4,MDFI,PKD1,KPNA1,UBR
al_p
5
roce
0
2
2.
9
9
E
0
2
2.
9
9
E
0
2
1.20
446
576
2
2.
9
9
E
0
2
1.56
658
517
4
3.
0
3
E
15
7
G
O:
00
31
64
7
G
O:
00
30
02
7
G
O:
00
60
34
8
G
O:
00
31
90
2
ss
regulation of protein stability
biol
ogic
SMAD7,USP4,PLK1,HPS4,MDM2,CREB1,USP3,PTEN,FBXW7,AAK1,C
al_p
TSH,ZSWIM7,FLNA,GAPDH
roce
ss
1.73
042
986
2
lamellipodium
cell
ular
DPP4,MCF2L,CAPZB,ACTR3,VASP,PKD2,FAP,PXN,SRGAP2,MYLK,S
_co
WAP70,DGKZ,ARHGEF7,CTTN,SSH1
mpo
nent
1.69
274
126
3
bone development
biol
ogic
COL9A1,COL2A1,GLG1,THBS3,RUNX2,MEF2A,DYM,PTPRC,EVC,SEM
al_p
A4D,GLI3,COL13A1,SMAD9
roce
ss
1.76
913
356
late endosome membrane
cell
ular
PLD1,HGS,NPC1,SLC11A2,VAMP7,HLA_co
DMB,IFITM3,STARD3,MCOLN1,TSG101,CD63
mpo
nent
1.87
715
372
6
0
2
3.
0
7
E
0
2
3.
1
1
E
0
2
3.
1
1
E
0
2
3.
1
2
E
0
2
G
O:
00
51
32
5
interphase
biol
ogic
al_p
roce
ss
small nuclear ribonucleoprotein complex
cell
ular
_co DDX23,PRPF3,SF3A2,PRPF8,TGS1,SNRPE
mpo
nent
2.46
941
078
3
leading edge membrane
cell
ular
FZD6,MYO1D,DPP4,VASP,DDX58,PTPRK,MAPK8IP3,FAP,EZR,ITGA5,
_co
TLN1,TWF1,ROBO2
mpo
nent
1.76
614
816
6
G
O:
00
32
43
4
regulation of proteasomal ubiquitindependent protein catabolic process
biol
ogic
al_p UBXN1,SMAD7,RAD23A,PLK1,WAC,MDM2,NUB1,PTEN,CSNK1E
roce
ss
2.02
089
487
4
G
O:
00
42
protein ubiquitination involved in ubiquitindependent protein catabolic process
biol
ogic
HERC2,MDM2,RNF217,PTEN,FBXW7,RNF146,OS9,WWP1,UBR5
al_p
roce
2.02
089
487
4
G
O:
00
30
53
2
G
O:
00
31
25
6
CDK14,KANK2,PSMB10,BCL6,PSMB9,CEP135,USP47,PTPN6,PRKAC
A,ANAPC4,PLK1,SDCCAG8,CAMK2D,GIGYF2,PAF1,MDM2,INO80,NU
MA1,PKD2,CASP2,RB1,PAFAH1B1,SLFN11,CHMP1A,PLK2,CUL4A,PT
EN,CDK5RAP2,PTPRC,PSMC6,CDK6,PSMC4,DGKZ,HINFP,DBF4,SMA
RCA4,DYNC1I2,PSMA1,CSNK1E,PKD1,CLASP1
1.34
726
324
9
3.
1
2
E
0
2
3.
1
5
E
0
2
3.
1
7
E
0
2
3.
1
9
E
0
2
3.
1
9
E
78
7
G
O:
00
42
32
5
G
O:
00
43
68
7
G
O:
00
02
76
4
G
O:
00
45
93
6
ss
0
2
regulation of phosphorylation
ACADVL,IGF1R,SIRT2,RAF1,ZFP91,CNTF,EEF2K,VAPB,SMAD7,RBPM
S,XBP1,ADAM8,DNAJC10,PTPN6,NOD1,PRKACA,PLK1,ASNS,HDGF,
biol CCNL1,FAM58A,TNK2,STK4,FGFR1,ADCY4,TAB2,SEC31A,PPM1F,NP
ogic TN,CCNL2,NF1,RPS6KA5,PKD2,LMNA,RB1,MAPK8IP3,SENP2,TPP1,S
al_p H3BP5,RGS3,GRB10,FLCN,NRP1,PTEN,IQGAP1,FBXW7,HERPUD1,P
roce XN,FECH,PRKRIP1,CSK,PTPRC,PAK1,NCK2,SEMA4D,CSF1R,C3,SMA
ss
D4,AK5,ENG,NOX4,PDIA5,MDFI,ITGA5,RGS2,PDGFRB,CARD14,TNFR
SF14,YIF1A,TLN1,GSK3A,TWF1,IGF2,PDCD4,CRIPAK,CDK5RAP1,NT
RK1,SPRED1,TNFRSF10B,DUSP6,PKD1,PDPK1,CDK5RAP3,WNK1
post-translational protein modification
biol
ogic ST3GAL1,GPAA1,PIGS,PIGG,PIGN,SEC31A,RHBDD1,MCFD2,ALG6,S
al_p T3GAL4,EDEM2,GALNT2,MAN1A2,MGAT5,B4GALT4,MAN2A2,MAN1B
roce 1,CANX,SUMF2,PIGO,PDIA3,ALG9
ss
1.51
998
930
7
immune response-regulating signaling
pathway
biol
ogic
al_p
roce
ss
BTN3A1,HLA-DPB1,PTPN22,HLADQA1,ADAM8,PTPN6,VASP,NOD1,RC3H1,TAB2,PRKCH,CREB1,DDX5
8,LCP2,RPS6KA5,NR1H3,PTEN,FYN,PHPT1,IKBKB,MEF2A,MAPK8,CS
K,PTPRC,PAK1,CTSH,CACNB3,DUSP6,PDPK1
1.43
115
876
3
negative regulation of phosphate metabolic
process
biol
ogic
al_p
roce
ss
IGF1R,SMAD7,DNAJC10,PTPN6,IGBP1,PLK1,PPM1F,NF1,RB1,SH3BP
5,RGS3,GRB10,FLCN,PTEN,IQGAP1,PRKRIP1,PTPRC,SEMA4D,ENG,
RGS2,LPCAT1,GSK3A,PDCD4,CRIPAK,CDK5RAP1,SPRED1,DUSP6,P
DPK1,WNK1
1.43
115
876
3
1.21
950
552
7
3.
2
1
E
0
2
3.
2
3
E
0
2
3.
2
3
E
0
2
3.
2
3
E
0
2
G
O:
00
10
56
3
negative regulation of phosphorus
metabolic process
biol
ogic
al_p
roce
ss
activated T cell proliferation
biol
ogic
al_p CADM1,BTN3A1,RC3H1,IL18,FYN,IGF2
roce
ss
2.44
956
954
4
transforming growth factor beta-activated
receptor activity
mol
ecul
ar_f
unct
ion
FKBP1A,LTBP4,ENG,TGFBR3
3.17
806
184
7
G
O:
00
04
67
5
transmembrane receptor protein
serine/threonine kinase activity
mol
ecul
ar_f
unct
ion
FKBP1A,LTBP4,ENG,TGFBR3
3.17
806
184
7
G
O:
basal transcription machinery binding
mol
ecul
WAC,PAF1,TCF4
4.05
202
G
O:
00
50
79
8
G
O:
00
05
02
4
IGF1R,SMAD7,DNAJC10,PTPN6,IGBP1,PLK1,PPM1F,NF1,RB1,SH3BP
5,RGS3,GRB10,FLCN,PTEN,IQGAP1,PRKRIP1,PTPRC,SEMA4D,ENG,
RGS2,LPCAT1,GSK3A,PDCD4,CRIPAK,CDK5RAP1,SPRED1,DUSP6,P
DPK1,WNK1
1.43
115
876
3
3.
2
3
E
0
2
3.
2
4
E
0
2
3.
2
7
E
0
2
3.
2
7
E
0
2
3.
2
00
01
09
8
G
O:
00
01
09
9
G
O:
00
30
37
1
G
O:
00
17
16
6
G
O:
00
05
52
1
ar_f
unct
ion
basal RNA polymerase II transcription
machinery binding
mol
ecul
ar_f
unct
ion
translation repressor activity
mol
ecul
ar_f
unct
ion
vinculin binding
mol
ecul
ar_f
unct
ion
lamin binding
mol
ecul
ar_f
unct
ion
885
5
WAC,PAF1,TCF4
4.05
202
885
5
ZNF540,CELF1,CIRBP
4.05
202
885
5
UTRN,PXN,TLN1
4.05
202
885
5
SYNE1,SUN2,NARF
4.05
202
885
5
8
E
0
2
3.
2
8
E
0
2
3.
2
8
E
0
2
3.
2
8
E
0
2
3.
2
8
E
0
2
G
O:
00
70
93
2
histone H3 deacetylation
biol
ogic
al_p HDAC6,SIRT7,ATXN3,SMARCAD1
roce
ss
3.17
003
117
5
regulation of cardiac muscle hypertrophy
biol
ogic
al_p CAMK2D,RGS2,GSK3A,LMCD1
roce
ss
3.17
003
117
5
regulation of dendritic spine morphogenesis
biol
ogic
al_p SIPA1L1,PDLIM5,CAPRIN1,PTEN
roce
ss
3.17
003
117
5
G
O:
00
72
35
0
tricarboxylic acid metabolic process
biol
ogic
al_p IDH3G,IDH1,IDH3B
roce
ss
4.04
178
974
8
G
O:
negative regulation of cell aging
biol
ogic
4.04
178
G
O:
00
10
61
1
G
O:
00
61
00
1
MARCH5,PTEN,CDK6
3.
3
0
E
0
2
3.
3
0
E
0
2
3.
3
0
E
0
2
3.
3
0
E
0
2
3.
3
00
90
34
4
G
O:
00
02
63
4
al_p
roce
ss
974
8
regulation of germinal center formation
biol
ogic
al_p BCL6,RC3H1,MEF2A
roce
ss
4.04
178
974
8
G
O:
00
08
58
9
regulation of smoothened signaling pathway
biol
ogic
al_p DISP1,RB1,RUNX2,TCTN1,EVC,GLI3,STK36,C2CD3
roce
ss
2.11
335
411
7
G
O:
00
02
56
2
somatic diversification of immune receptors
via germline recombination within a single
locus
biol
ogic
al_p BCL6,LEF1,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.11
335
411
7
somatic cell DNA recombination
biol
ogic
al_p BCL6,LEF1,RNF8,RNF168,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
2.11
335
411
7
G
O:
00
16
44
4
0
E
0
2
3.
3
0
E
0
2
3.
3
0
E
0
2
3.
3
0
E
0
2
3.
3
0
E
0
2
G
O:
00
16
48
5
protein processing
biol
ogic
CPE,GLG1,ADAM8,C2,CFB,MDM2,RHBDD1,CASP2,IFT172,CTSH,C3,
al_p
GLI3,PCSK7,LONP2,SPCS3,C2CD3
roce
ss
1.64
551
236
6
interaction with host
biol
ogic
al_p
roce
ss
1.34
072
313
6
positive regulation of protein binding
biol
ogic
al_p CRBN,KRIT1,FKBP1A,NRP1,HERPUD1,MEF2A,PKD1
roce
ss
2.24
543
874
9
G
O:
00
44
45
4
nuclear chromosome part
cell
ular OBFC1,CBX5,EED,CSNK2A1,PLK1,TBP,YY1,INO80,CREB1,USP3,NR1
_co H3,RUNX2,SMARCD3,NCOR1,MEF2A,TRIM28,ACD,INO80E,SUN2,SIR
mpo T7,ERCC1,PHF12,NCAPD3,SMARCA4,STAT6,FOXC1,SMARCAD1
nent
1.44
758
563
2
G
O:
regulation of nitrogen compound metabolic
process
biol
ogic
1.09
027
G
O:
00
51
70
1
G
O:
00
32
09
2
PSMB10,F11R,CDK13,CBX5,VAPB,NUP98,ATP6V1D,VRK2,HLAC,PSMB9,BCL2L11,FDPS,RAD23A,STAT2,MDM2,TBP,CREB1,DDX58,I
FITM3,RB1,BICD1,USP7,CUL4A,FYN,SRPK1,FBXW7,KPNB1,LTBR,SP
110,ATP6V0A1,KLC1,THOC2,SLC25A6,WWP1,ITGA5,TNFRSF14,RPLP
0,DYNC1I2,TSG101,KPNA1,PABPN1
FZD6,OBFC1,RAB3GAP2,PBX2,KANK2,ACADVL,RAI1,PSMB10,IGF1R,
SIRT2,RALGAPA2,MYNN,NOC2L,RAF1,ZNF131,RSC1A1,SFSWAP,CD
3.
3
2
E
0
2
3.
3
4
E
0
2
3.
3
4
E
0
2
3.
3
7
E
0
2
3.
4
00
51
17
1
al_p K13,SIN3B,CBX5,SUPT5H,SUPT20H,BCL6,FUBP1,ZNF783,TBX2,MMS
roce 19,VAPB,CUX1,EED,SMAD7,MCF2L,HDAC6,ARHGEF12,EHMT1,ZNF4
ss
96,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,PSMB9,EMX2,RBPMS,STAR
D13,ZSCAN31,XBP1,PAM,SNRNP70,USP47,ADAM8,GABPB1,DNAJC1
0,PCGF6,RANBP1,SIPA1L1,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,ST
AT2,PLK1,ZNF446,ASNS,TBC1D2B,PTGES2,ZNF621,HDGF,CCNL1,C
HD6,ZC3H12A,TBC1D10B,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,
ZNF721,ZNF397,JHDM1D,ZNF710,TBC1D14,GIT2,WAC,ZNF142,FUBP
3,ZNF540,FGFR1,HSF4,CELF1,PAF1,TAB2,SGK1,DPF2,RNF8,SEC31A
,MDM2,PRKCH,PPM1F,ZNF595,TBP,YY1,FAM13A,INO80,GMEB2,PFD
N5,CREB1,FLII,RPRD1A,DDX58,CCNL2,PTPRK,SNX13,NF1,ZEB1,IFIT
M3,ASCC2,RGMB,EBF1,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,BRD9,Z
NF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,R
NF168,PAFAH1B1,ZNF865,SENP2,TPP1,SUB1,CHMP1A,PDE8A,ACAP
2,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,RGS3,NR1H3,USP7,FLCN,Z
NF605,ZNF410,ARHGAP9,SAP30BP,VPS72,PTEN,SRPK1,RUNX2,IQG
AP1,FBXW7,SMARCD3,HERPUD1,IKBKB,RQCD1,SRGAP2,RFX7,NCO
R1,MEF2A,SETD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX3,ZNF56
5,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,PTPRC,OAZ1,PSMC6,TBC
D,UBP1,WDR61,EBF4,ZNF148,ZNF76,PSMC4,ARHGAP29,SGSM3,ST
AG2,SP110,NCK2,TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,N
FYC,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,DDAH1,INO80E,ZNF44,CR
EBZF,ING4,ZNF687,CLK3,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,T
MED2,MAPK12,CCDC59,DCAF6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,N
OX4,ZNF692,ERCC1,PHF1,STK36,WWP1,ARHGEF7,PHF12,PDIA5,AS
AP1,MED6,MDFI,ZNF554,CIZ1,RGS2,HINFP,NCBP2,LPCAT1,MLX,PD
GFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,SMARCA4,NAA16,LR
PPRC,YIF1A,RAD54L2,ZNF518B,CLK4,ZNF90,ZNF638,PER3,TLN1,GS
K3A,ZNF383,NCOR2,SETD2,IGF2,PTGIS,ATXN3,PHF21A,PDCD4,SOX
13,CHD2,PSMA1,STAT6,SON,ZNF138,ZNF705A,BNIP2,NTRK1,TFAM,
BRWD1,SMAD9,HBB,TGFBR3,ZBTB16,BAZ2A,RRP8,PHF19,LMCD1,P
083
8
1
E
0
2
KD1,PDPK1,TSG101,USF1,FOXC1,KPNA1,DDAH2,CDK5RAP3,RAPGE
F6,PABPC1,UBR5,FASTK,EYA2,SMARCAD1,CC2D1A,GATA2
G
O:
00
60
34
3
trabecula formation
biol
ogic
al_p ADAMTS1,FKBP1A,THBS3,SMARCA4,TGFBR3
roce
ss
2.69
452
649
9
spinal cord motor neuron differentiation
biol
ogic
al_p LHX4,CLN8,GIGYF2,TCTN1,GLI3
roce
ss
2.69
452
649
9
developmental programmed cell death
biol
ogic
al_p BDNF,CNTF,LEF1,PAX8,NTRK1
roce
ss
2.69
452
649
9
G
O:
00
97
06
1
dendritic spine organization
biol
ogic
al_p SIPA1L1,PDLIM5,CAPRIN1,PTEN,TANC1
roce
ss
2.69
452
649
9
G
O:
C-terminal protein lipidation
biol
ogic
2.69
452
G
O:
00
21
52
2
G
O:
00
10
62
3
GPAA1,PIGS,PIGG,PIGN,PIGO
3.
4
1
E
0
2
3.
4
1
E
0
2
3.
4
1
E
0
2
3.
4
1
E
0
2
3.
4
00
06
50
1
G
O:
00
17
05
3
G
O:
00
70
06
2
G
O:
00
31
40
0
G
O:
00
02
25
3
al_p
roce
ss
649
9
transcriptional repressor complex
cell
ular
_co CBX5,CSNK2A1,HDGF,NCOR1,APPL2,GLI3,PHF12,NCOR2,ZBTB16
mpo
nent
1.99
904
682
5
extracellular vesicular exosome
cell
ular
_co LAMB1,DPP4,COL12A1,LGALS3BP,ANXA5,C3,FLNA,GAPDH,TLN1
mpo
nent
1.99
904
682
5
negative regulation of protein modification
process
biol
ogic
al_p
roce
ss
PSMB10,IGF1R,NOC2L,UBXN1,SMAD7,USP4,PSMB9,DNAJC10,PTPN
6,IGBP1,ANAPC4,PLK1,PPM1F,NF1,RB1,SH3BP5,RGS3,PTEN,PRKRI
P1,PTPRC,PSMC6,PSMC4,SEMA4D,ENG,PHF1,RGS2,PDCD4,CRIPAK
,PSMA1,CDK5RAP1,SPRED1,DUSP6,PDPK1,UBR5,WNK1
1.37
475
841
8
activation of immune response
biol
ogic
al_p
roce
ss
BTN3A1,HLA-DPB1,PTPN22,HLADQA1,ADAM8,PTPN6,VASP,NOD1,RC3H1,C2,CFB,TAB2,PRKCH,CRE
B1,DDX58,LCP2,RPS6KA5,NR1H3,PTEN,FYN,C1R,PHPT1,IKBKB,MEF
2A,MAPK8,CSK,PTPRC,PAK1,C3,C1S,CACNB3,DUSP6,PDPK1
1.38
936
522
6
1
E
0
2
3.
4
2
E
0
2
3.
4
2
E
0
2
3.
4
2
E
0
2
3.
4
2
E
0
2
G
O:
00
05
72
0
nuclear heterochromatin
cell
ular
_co CBX5,EED,TRIM28,NCAPD3,FOXC1
mpo
nent
2.69
102
457
2
regulation of cell motility
biol
ogic
al_p
roce
ss
1.33
141
309
3
cell-substrate junction assembly
biol
ogic
al_p PPM1F,PTPRK,PTEN,PXN,TNS1,ITGA5,TLN1,CD151,PDPK1
roce
ss
1.98
776
545
G
O:
00
38
12
7
ERBB signaling pathway
biol
ogic RAF1,HGS,PRKACA,ADCY4,MDM2,CREB1,RHBDF1,RPS6KA5,PTEN,
al_p FBXW7,PXN,CSK,NCK2,EPS15L1,EPN1,ARHGEF7,STAM2,GSK3A,PD
roce PK1
ss
1.56
085
376
4
G
O:
regulation of cellular macromolecule
biosynthetic process
biol
ogic
1.09
837
G
O:
20
00
14
5
G
O:
00
07
04
4
IGF1R,LAMB1,RAF1,SMAD7,HDAC6,LEF1,NISCH,ADAM8,KRIT1,MINK
1,JAG2,AAMP,SGK1,PPM1F,DDX58,PTPRK,NF1,COL18A1,LMNA,NEX
N,FLCN,NRP1,PTEN,PHPT1,SRGAP2,MYLK,PTPRC,CDK6,RARRES2,
SEMA6A,CTSH,SEMA4D,CSF1R,SUN2,ENG,NOX4,PDGFRB,ELP6,CLI
C4,TGFBR3,PDPK1,STK24
FZD6,OBFC1,PBX2,KANK2,EIF2B4,RAI1,IGF1R,TNRC6A,SIRT2,MYNN
,TRNAU1AP,NOC2L,ZNF131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,S
3.
4
5
E
0
2
3.
4
8
E
0
2
3.
5
1
E
0
2
3.
5
2
E
0
2
3.
5
20
00
11
2
G
O:
enzyme linked receptor protein signaling
pathway
al_p UPT5H,BCL6,FUBP1,ZNF783,TBX2,MMS19,CUX1,EED,FMR1,SMAD7,
roce MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,
ss
EMX2,RBPMS,ZSCAN31,XBP1,PAM,UHMK1,USP47,ADAM8,GABPB1,
PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,STAT2,PLK1,ZN
F446,PTGES2,UPF1,ZNF621,HDGF,CCNL1,CHD6,ZC3H12A,FAM58A,T
BX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,GI
GYF2,WAC,ZNF142,FUBP3,ZNF540,FGFR1,HSF4,PAIP1,CAPRIN1,CE
LF1,PAF1,TAB2,SGK1,DPF2,RNF8,MDM2,PRKCH,PPM1F,ZNF595,TBP
,YY1,INO80,GMEB2,PFDN5,CREB1,SRP9,FLII,RPRD1A,DDX58,CCNL2
,PTPRK,ZEB1,EIF4B,ASCC2,RGMB,EBF1,MED28,ZNF3,RPS6KA5,NIP
BL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,
TP53BP1,RNF168,ZNF865,SENP2,PUM2,SUB1,CHMP1A,PDE8A,ZNF5
58,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GRB10,USP7,FLCN,ZNF60
5,ZNF410,SAP30BP,VPS72,PTEN,RUNX2,FBXW7,SMARCD3,IKBKB,R
QCD1,RFX7,NCOR1,MEF2A,FECH,SETD8,NECAB3,PIAS2,MAPK8,MY
CBP2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK
5RAP2,UBP1,WDR61,EBF4,ZNF148,ZNF76,STAG2,SP110,NCK2,TCF4,
ACD,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,NFYC,PIWIL4,SRSF10,SS1
8,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,ZNF44,CREBZF,ING4,ZNF687,
NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,MAPK12,CCDC59,DCAF6,E
NG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZNF692,GAPDH,PHF1,STK3
6,WWP1,PHF12,MED6,MDFI,CIRBP,ZNF554,CIZ1,RGS2,HINFP,NCBP2
,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,MKNK2,SMA
RCA4,NAA16,LRPPRC,ZNF518B,ZNF90,ZNF638,PER3,GSK3A,ZNF383
,NCOR2,SETD2,IGF2,PTGIS,ATXN3,PSTK,PHF21A,PDCD4,SOX13,CH
D2,STAT6,ZNF138,ZNF705A,NTRK1,TFAM,BRWD1,SMAD9,TGFBR3,Z
BTB16,BAZ2A,RRP8,VARS,LARS,PHF19,LMCD1,PKD1,PDPK1,TSG10
1,USF1,FOXC1,CDK5RAP3,PABPC1,EYA2,SMARCAD1,CC2D1A,GATA
2
biol IGF1R,RAF1,F11R,EEF2K,SMAD7,MCF2L,GLG1,ARHGEF12,ATP6V1D
ogic ,HGS,LEF1,BCL2L11,RBPMS,SIPA1L1,PTPN6,PRKACA,GIGYF2,FGFR
593
6
2
E
0
2
1.21
669
3.
5
00
07
16
7
G
O:
00
03
72
9
G
O:
00
08
08
1
G
O:
00
06
91
5
al_p 1,ADCY4,MDM2,FKBP1A,CREB1,NPTN,PLEKHG5,LCP2,PTPRK,RHBD
roce F1,ZEB1,EIF4B,RGMB,NPR1,RPS6KA5,CASP2,LTBP4,GRB10,FLCN,N
ss
RP1,PTEN,RUNX2,FBXW7,IKBKB,PXN,PTPRF,NCOR1,MEF2A,LIFR,FI
BP,MAPK8,USP15,CSK,NCK2,LEPROT,RHEB,CSF1R,ATP6V0A1,SS18
,SMAD4,TGFB1I1,MAPK12,RASGRF2,EPS15L1,EPN1,ENG,ARNT,ARH
GEF7,PTPRD,ITGA5,STAM2,PDGFRB,FGF14,GSK3A,NCOR2,IGF2,MY
O1E,NTRK1,MPZL1,SMAD9,DUSP6,TGFBR3,PDPK1,FOXC1,FMOD
148
1
mRNA binding
mol
ecul
ar_f
unct
ion
FMR1,RBPMS,RC3H1,FYTTD1,CELF1,SERBP1,G3BP1,PARN,FECH,CI
RBP,LUC7L3,PABPC1
1.78
111
158
5
phosphoric diester hydrolase activity
mol
ecul
ar_f
unct
ion
PLCD1,PLD1,SMPD4,PRKACA,PDE7B,CNP,PLCB4,FGFR1,ADCY4,PD
E4D,CREB1,GPCPD1,PDE8A,BICD1,PLD6,PDGFRB,PDIA3,NTRK1
1.57
871
254
1
apoptotic process
KANK2,CADM1,PSMB10,IGF1R,NOC2L,RAF1,NLRP1,PPP1R13B,BDN
F,SART1,COL2A1,BCL6,CNTF,SMAD7,MCF2L,HDAC6,ARHGEF12,CA
SP4,LEF1,PAX8,PSMB9,BCL2L13,BCL2L11,NISCH,USP47,ADAM8,NO
biol L3,DNAJC10,XAF1,KRIT1,PTPN6,LHX4,CSNK2A1,IGBP1,NOD1,PLK1,
ogic ASNS,JAG2,DNM1L,SHISA5,ZC3H12A,SEPT4,SLC11A2,CLN8,BCLAF1
al_p ,STK4,FGFR1,SGK1,SHARPIN,DPF2,TCHP,MDM2,RHBDD1,PRKCH,P
roce PM1F,TNFRSF25,PLEKHG5,DFNA5,NF1,CRIP1,COL18A1,RTKN,CAPN
ss
10,CASP2,LMNA,MITF,RB1,TXNDC5,MFSD10,IL18,MTCH1,ANXA5,PL
K2,FLCN,CUL4A,SAP30BP,PTEN,FYN,ALDH1A3,LGMN,HERPUD1,KP
NB1,LTBR,MEF2A,MAPK8,DDX41,PTPRC,PSMC6,EMC4,PSMC4,PAK1
,SEMA6A,CTSH,SEMA4D,TIMM50,ING4,GLI3,RASGRF2,NOX4,GAPDH
1.15
747
190
1
5
E
0
2
3.
5
7
E
0
2
3.
5
9
E
0
2
3.
6
2
E
0
2
G
O:
00
12
50
1
programmed cell death
G
O:
00
72
35
8
cardiovascular system development
G
O:
00
circulatory system development
,ERCC1,TEX261,NRBP2,SLC25A6,ARHGEF7,UNC5B,ITGA5,CDK11A,
CARD14,DIABLO,MKNK2,LMNB1,PDIA3,PTGIS,PDCD4,PSMA1,ACIN1,
ROBO2,SON,BNIP2,NTRK1,TNFRSF10B,ATG3,DUSP6,ZBTB16,RRP8,
LUC7L3,PDPK1,FOXC1,KPNA1,DDAH2,STK24,FASTK,EYA2,BCL2L2PABPN1,BCL2L2
KANK2,CADM1,PSMB10,IGF1R,NOC2L,RAF1,NLRP1,PPP1R13B,BDN
F,SART1,COL2A1,BCL6,CNTF,SMAD7,MCF2L,HDAC6,ARHGEF12,CA
SP4,LEF1,PAX8,PSMB9,BCL2L13,BCL2L11,NISCH,MARK4,USP47,AD
AM8,NOL3,DNAJC10,XAF1,KRIT1,PTPN6,LHX4,CSNK2A1,IGBP1,NOD
1,PLK1,ASNS,JAG2,DNM1L,SHISA5,ZC3H12A,SEPT4,SLC11A2,CLN8,
BCLAF1,STK4,FGFR1,SGK1,SHARPIN,DPF2,TCHP,MDM2,RHBDD1,P
biol
RKCH,PPM1F,TNFRSF25,PLEKHG5,DFNA5,NF1,CRIP1,COL18A1,RTK 1.15
ogic
N,CAPN10,CASP2,LMNA,MITF,RB1,TXNDC5,MFSD10,IL18,MTCH1,AN 648
al_p
XA5,PLK2,FLCN,CUL4A,SAP30BP,PTEN,FYN,ALDH1A3,LGMN,HERPU 537
roce
D1,KPNB1,LTBR,MEF2A,MAPK8,DDX41,PTPRC,PSMC6,EMC4,PSMC4
1
ss
,PAK1,SEMA6A,CTSH,SEMA4D,TIMM50,ING4,GLI3,RASGRF2,NOX4,G
APDH,ERCC1,TEX261,NRBP2,SLC25A6,ARHGEF7,UNC5B,ITGA5,CD
K11A,CARD14,DIABLO,MKNK2,LMNB1,PDIA3,PTGIS,PDCD4,PSMA1,A
CIN1,ROBO2,SON,BNIP2,NTRK1,TNFRSF10B,ATG3,DUSP6,ZBTB16,R
RP8,LUC7L3,PDPK1,FOXC1,KPNA1,DDAH2,STK24,FASTK,EYA2,BCL
2L2-PABPN1,BCL2L2
FZD6,NPHP3,RAF1,TAZ,SIN3B,CPE,PLCD1,COL2A1,TBX2,SMAD7,RN
H1,LEF1,ADAMTS1,PAM,ADAM8,KRIT1,ZC3H12A,AAMP,TBX18,STK4,
biol
FGFR1,TAB2,FKBP1A,NF1,CRIP1,COL18A1,NPR1,NIPBL,PKD2,SLC12 1.23
ogic
A6,RXRB,LMNA,ZFPM2,SENP2,IL18,ADAM15,NRP1,PTEN,FBXW7,SM 256
al_p
ARCD3,MEF2A,OXCT1,MYLK,UBP1,CTSH,C3,DDAH1,GLI3,TMED2,EN 612
roce
G,NOX4,GAA,ITGA5,PDGFRB,COL8A1,EPOR,RUNX1,SMARCA4,GSK
4
ss
3A,NCOR2,SETD2,PTGIS,MYO1E,CLIC4,NTRK1,DUSP6,TGFBR3,PKD
1,FOXC1,C2CD3,TENM4,GATA2
biol FZD6,NPHP3,RAF1,TAZ,SIN3B,CPE,PLCD1,COL2A1,TBX2,SMAD7,RN 1.23
ogic H1,LEF1,ADAMTS1,PAM,ADAM8,KRIT1,ZC3H12A,AAMP,TBX18,STK4, 256
al_p FGFR1,TAB2,FKBP1A,NF1,CRIP1,COL18A1,NPR1,NIPBL,PKD2,SLC12 612
3.
6
4
E
0
2
3.
6
8
E
0
2
3.
6
8
72
35
9
G
O:
00
21
51
7
G
O:
00
06
50
6
G
O:
00
31
96
6
G
O:
00
10
76
9
roce A6,RXRB,LMNA,ZFPM2,SENP2,IL18,ADAM15,NRP1,PTEN,FBXW7,SM
ss
ARCD3,MEF2A,OXCT1,MYLK,UBP1,CTSH,C3,DDAH1,GLI3,TMED2,EN
G,NOX4,GAA,ITGA5,PDGFRB,COL8A1,EPOR,RUNX1,SMARCA4,GSK
3A,NCOR2,SETD2,PTGIS,MYO1E,CLIC4,NTRK1,DUSP6,TGFBR3,PKD
1,FOXC1,C2CD3,TENM4,GATA2
4
ventral spinal cord development
biol
ogic
al_p LHX4,CLN8,GIGYF2,TCTN1,GLI3,GATA2
roce
ss
2.37
752
338
1
GPI anchor biosynthetic process
biol
ogic
al_p GPAA1,PIGS,PIGG,PIGN,PIGO,ALG9
roce
ss
2.37
752
338
1
mitochondrial membrane
cell
ular
_co
mpo
nent
regulation of cell morphogenesis involved in
differentiation
biol
ogic SMAD7,LEF1,PAX8,SIPA1L1,PDLIM5,ACTR3,CAPRIN1,SSH2,PAFAH1
al_p B1,ARPC2,NRP1,PTEN,SEMA4D,SMAD4,TGFB1I1,PTPRD,KIF13B,RO
roce BO2,TGFBR3,STK24,SSH1
ss
SLC25A37,ACADVL,RAF1,TAZ,MARCH5,SHMT2,PGS1,SLC9B2,VRK2,
BCL2L13,BCL2L11,STARD13,TTC19,DNM1L,FDXR,HERC2,CNP,GCDH
,ALDH18A1,TIMM23,CPT1B,GPAT2,DHRS1,MTCH1,PLD6,SRGAP2,FE
CH,ERAL1,COX7A2L,COX14,TIMM50,GRPEL2,BCS1L,ATP5A1,NDUFV
1,NDUFS2,SLC25A6,SDHA,LETMD1,POLG,FPGS,SFXN3,ATXN3,SLC2
5A24,SLC25A46,LETM1,UQCRH,BCL2L2
1.29
918
710
5
1.51
296
942
4
E
0
2
3.
7
0
E
0
2
3.
7
0
E
0
2
3.
7
3
E
0
2
3.
7
4
E
0
2
G
O:
00
01
89
4
G
O:
00
01
93
4
G
O:
00
44
44
8
G
O:
00
03
67
6
tissue homeostasis
biol
ogic
COL9A1,COL2A1,ADAM8,BBS1,GIGYF2,NF1,TPP1,CSK,CTSH,CSF1R,
al_p
NOX4,LPCAT1,PDGFRB,GATA2
roce
ss
1.68
407
906
2
positive regulation of protein
phosphorylation
biol
ogic
al_p
roce
ss
ACADVL,IGF1R,RAF1,ZFP91,CNTF,VAPB,RBPMS,XBP1,ADAM8,NOD1
,PRKACA,PLK1,ASNS,HDGF,TNK2,STK4,FGFR1,ADCY4,TAB2,SEC31
A,NPTN,RPS6KA5,PKD2,LMNA,MAPK8IP3,SENP2,TPP1,FLCN,NRP1,I
QGAP1,FBXW7,HERPUD1,PXN,CSK,PTPRC,PAK1,SEMA4D,CSF1R,C
3,SMAD4,ENG,NOX4,PDIA5,MDFI,ITGA5,PDGFRB,CARD14,TNFRSF1
4,YIF1A,TLN1,GSK3A,IGF2,NTRK1,TNFRSF10B,PKD1,PDPK1
1.27
014
717
1
cell cortex part
cell
ular
SEPT5,LANCL2,CAPZB,SEPT4,TCHP,TPM4,MED28,PKD2,RAB10,EZR
_co
,SEPT2,CLASP1
mpo
nent
1.76
757
824
5
nucleic acid binding
mol
ecul
ar_f
unct
ion
OBFC1,PBX2,DHX34,EIF2B4,GTF3C2,XRN1,TNRC6A,MYNN,TRNAU1
AP,ZNF131,SFSWAP,RBM6,ERCC6L2,BCL6,FUBP1,ZNF783,TBX2,ZFP
91,EEF2K,CUX1,RBM17,FMR1,SMAD7,PPFIBP2,ZNF496,NARS,PNKP,
LEF1,PAX8,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,NOM1,SNRNP70,D
DX23,RAD23A,METTL3,APITD1,UHMK1,NOL3,GABPB1,PCGF6,DDX39
A,SKIV2L,SUGP1,EEF1A1,LHX4,UPF3A,STAT2,RPP14,DHX9,ZNF446,
PTGES2,TNRC18,UPF1,ZNF621,HDGF,RC3H1,CHD6,POLM,CNP,TBX
18,LBX2,DR1,BCLAF1,FYTTD1,ZNF721,ZNF397,ZNF710,PRPF3,ZNF1
42,FUBP3,RARS,ZNF540,HSF4,PAIP1,CAPRIN1,GTF3C1,PMS1,CELF1
1.09
762
405
3.
7
5
E
0
2
3.
7
7
E
0
2
3.
7
9
E
0
2
3.
7
9
E
0
2
,RNASET2,SF3A2,ZCCHC14,DAZAP1,ZNF595,TBP,DIS3L,YY1,INO80,
GMEB2,SSH2,CREB1,SRP9,DDX58,ZCCHC9,ZEB1,EIF4B,CRIP1,SER
BP1,SETBP1,EBF1,RPL9,UNKL,ZNF3,G3BP1,BRD9,ZNF837,HNRNPA3
,RXRB,RSL1D1,MITF,NOL8,RB1,HMGXB3,MZF1,ZFPM2,TP53BP1,ZNF
865,PUM2,SLFN11,SUB1,FAM200B,DDX6,ZNF558,ZNF263,ZNF180,BI
CD1,ZNF276,NR1H3,MRPS7,PAN2,ZNF605,ZNF410,RPL24,VPS72,RU
NX2,CSTF1,RFX7,NCOR1,PPP1R10,MEF2A,PARN,FECH,ERAL1,PRK
RIP1,PIAS2,SSBP1,DDX41,SRRM2,PBX3,N6AMT1,ZNF565,TRIM28,D
MTF1,CDK5RAP2,SWAP70,IMPDH1,UBP1,SKIV2L2,EBF4,PRPF8,FAR
SA,ZNF148,ZNF76,HNRNPL,SP110,HNRNPH3,TCF4,ACD,IKZF5,HMG
N2,SSBP2,TIMM50,NFYC,PIWIL4,RPUSD4,SRSF10,RCOR3,SMAD4,Z
NF114,MIER2,RPL4,CENPT,ZNF44,CREBZF,RBMS1,EIF3M,ZNF687,N
R2C2,FIP1L1,IRF9,GLI3,THOC2,ZSCAN5A,TCF12,ARNT,ZNF692,ERC
C1,MTRF1L,BICC1,REXO2,MED6,MDFI,CIRBP,ZNF554,CIZ1,HINFP,N
CBP2,MLX,RAD51B,GLIS3,BDP1,DBF4,RUNX1,SMARCA4,LRPPRC,R
PLP0,DHX40,RAD54L2,ZNF518B,ZNF90,ZNF638,CHTF8,PHC3,DNAJC
21,SNRPE,THUMPD2,POLG,ZNF383,MRPL3,POLR2J3,NCOR2,SETD2,
TROVE2,ATXN3,NUCB1,PSTK,PHF21A,PDCD4,SOX13,ERI3,CHD2,LO
NP2,ZBED5,PSMA1,STAT6,ACIN1,SON,ZNF138,ZNF705A,TFAM,SHPR
H,SMAD9,ZBTB16,BAZ2A,EIF3I,DHX37,LUC7L3,TSG101,THAP6,USF1,
FOXC1,ZC3H14,HEMK1,SSH1,PABPC1,UBR5,PHC2,SMARCAD1,CC2
D1A,ZC3H15,GATA2,PABPN1
G
O:
00
43
48
4
G
O:
00
regulation of RNA splicing
biol
ogic
al_p SFSWAP,SNRNP70,CELF1,SRPK1,SRSF10,CLK3,CLK4,SON,FASTK
roce
ss
1.95
570
471
7
cardiac chamber morphogenesis
biol
ogic
al_p
1.71
710
022
CPE,TBX2,SMAD7,ADAMTS1,FKBP1A,ZFPM2,SMARCD3,MEF2A,GAA,
SMARCA4,GSK3A,TGFBR3,FOXC1
3.
8
4
E
0
2
3.
8
4
03
20
6
G
O:
00
08
23
4
G
O:
00
00
77
6
G
O:
00
30
67
3
G
O:
00
17
11
9
roce
ss
cysteine-type peptidase activity
mol
ecul
ar_f
unct
ion
USP10,RAF1,NLRP1,USP4,CASP4,LEF1,BCL2L13,BCL2L11,USP47,CS
NK2A1,IGBP1,NOD1,SLC11A2,ATG4B,USP20,MDM2,PPM1F,CAPN10,
CASP2,USP24,USP3,SENP2,MTCH1,USP33,USP7,LGMN,HERPUD1,U
SP15,CTSH,DIABLO,USP40,ATG4A,PDIA3,ATXN3,TNFRSF10B,SENP6
1.35
443
861
4
kinetochore
cell
ular
CBX5,NUP98,DYNC1I1,APITD1,PLK1,TP53BP1,PAFAH1B1,DSN1,NUP
_co
37,CENPT,NUP85,SEPT2,CLASP1
mpo
nent
1.71
616
284
axolemma
cell
ular
_co MYO1D,MAPK8IP3,ROBO2
mpo
nent
3.81
636
212
Golgi transport complex
cell
ular
_co COG4,SCFD1,VPS51
mpo
nent
3.81
636
212
E
0
2
3.
8
7
E
0
2
3.
8
8
E
0
2
3.
8
9
E
0
2
3.
8
9
E
0
2
G
O:
00
05
74
4
mitochondrial inner membrane presequence
translocase complex
cell
ular
_co TIMM23,TIMM50,SLC25A6
mpo
nent
3.81
636
212
organ growth
biol
ogic
TBX2,BCL2L11,STK4,FGFR1,RXRB,PTEN,MEF2A,GSK3A,DUSP6,TGF
al_p
BR3,FOXC1,TENM4
roce
ss
1.75
729
989
adult locomotory behavior
biol
ogic
al_p NPC1,CNP,CLN8,GIGYF2,PAFAH1B1,HEXA,CTNS,PBX3,TBCE,FGF14
roce
ss
1.87
119
895
7
G
O:
00
33
67
3
negative regulation of kinase activity
biol
ogic IGF1R,PTPN6,PLK1,PPM1F,NF1,RB1,SH3BP5,RGS3,PTEN,PRKRIP1,
al_p CSK,PTPRC,RGS2,PDCD4,CRIPAK,CDK5RAP1,SPRED1,DUSP6,PDP
roce K1,WNK1
ss
1.52
233
135
5
G
O:
00
90
negative regulation of canonical Wnt
receptor signaling pathway
biol
ogic FZD6,NPHP3,LEF1,TBX18,STK4,PFDN5,G3BP1,GLI3,BICC1,GSK3A,A
al_p NKRD6
roce
1.80
730
435
9
G
O:
00
35
26
5
G
O:
00
08
34
4
3.
8
9
E
0
2
3.
9
1
E
0
2
3.
9
3
E
0
2
3.
9
3
E
0
2
3.
9
4
E
09
0
G
O:
00
42
11
0
G
O:
00
16
88
1
ss
T cell activation
biol
ogic
al_p
roce
ss
CADM1,PSMB10,BTN3A1,SART1,HLADPB1,DPP4,BCL6,PTPN22,LEF1,HLADQA1,ADAM8,MINK1,PTPN6,JAG2,RC3H1,FKBP1A,ZEB1,IL18,FYN,R
UNX2,NCOR1,CSK,PTPRC,CDK6,PAK1,NCK2,CD276,GLI3,LGALS8,TN
FRSF14,KIF13B,IGF2,STAT6,CD151,PDPK1
1.35
891
105
8
acid-amino acid ligase activity
mol
ecul
ar_f
unct
ion
PSMB10,PPIL2,MARCH5,ZFP91,SMAD7,TTLL3,PSMB9,RNF220,MARC
H6,ANAPC4,PLK1,RC3H1,HERC2,MIB2,RNF8,MDM2,UBE2Q1,RNF168
,RNF217,CHFR,PTEN,TMEM189,PIAS2,MYCBP2,RNF213,TRIM28,PSM
C6,RNF146,PSMC4,CDC14B,WWP1,TTLL11,FBXW2,FPGS,AMFR,PSM
A1,ATG3,UBR5
1.34
009
657
5
G
O:
00
10
94
1
regulation of cell death
G
O:
negative regulation of transcription from
RNA polymerase II promoter
KANK2,PSMB10,IGF1R,NOC2L,RAF1,NLRP1,PPP1R13B,BDNF,SART1
,COL2A1,RILPL1,BCL6,CNTF,SMAD7,HDAC6,CASP4,LEF1,PAX8,PSM
B9,BCL2L13,BCL2L11,MARK4,USP47,ADAM8,NOL3,DNAJC10,KRIT1,L
HX4,CSNK2A1,IGBP1,NOD1,PLK1,ASNS,JAG2,DNM1L,SHISA5,SEPT4
biol ,SLC11A2,CLN8,BCLAF1,STK4,FGFR1,SGK1,DPF2,MDM2,RHBDD1,P
ogic RKCH,PPM1F,TNFRSF25,DFNA5,NF1,COL18A1,CAPN10,CASP2,LMN
al_p A,MITF,ZFPM2,TXNDC5,IL18,MTCH1,ANXA5,PLK2,FLCN,CUL4A,SAP3
roce 0BP,PTEN,FYN,ALDH1A3,LGMN,HERPUD1,SRGAP2,LTBR,MEF2A,MA
ss
PK8,PTPRC,PSMC6,PSMC4,CTSH,SEMA4D,TIMM50,SMAD4,ING4,GLI
3,NOX4,ERCC1,TEX261,NRBP2,ARHGEF7,UNC5B,ITGA5,CARD14,DI
ABLO,PDIA3,PTGIS,PSMA1,SON,BNIP2,NTRK1,TNFRSF10B,HBB,DUS
P6,ZBTB16,RRP8,PDPK1,FOXC1,DDAH2,STK24,FASTK,BCL2L2PABPN1,BCL2L2
biol KANK2,NOC2L,SUPT5H,BCL6,TBX2,CUX1,SMAD7,EHMT1,ZNF496,LE
ogic F1,SUPT4H1,IGBP1,PLK1,HDGF,TBX18,DR1,FGFR1,HSF4,PAF1,MDM
0
2
3.
9
5
E
0
2
3.
9
5
E
0
2
1.17
524
946
4
3.
9
6
E
0
2
1.28
191
3.
9
00
00
12
2
al_p 2,YY1,ZEB1,NIPBL,RB1,PRMT5,ZFPM2,NR1H3,FLCN,VPS72,NCOR1,
roce MEF2A,SETD8,TRIM28,ZNF148,TCF4,SEMA4D,SMAD4,GLI3,ENG,SIR
ss
T7,PHF12,MDFI,GLIS3,SMARCA4,PER3,NCOR2,PHF21A,STAT6,LMC
D1,CC2D1A,GATA2
G
O:
00
33
14
4
negative regulation of intracellular steroid
hormone receptor signaling pathway
biol
ogic
al_p KANK2,RQCD1,PIAS2,SMARCA4,CRIPAK
roce
ss
2.59
089
086
4
regulation of transcription elongation from
RNA polymerase II promoter
biol
ogic
al_p SUPT5H,SUPT4H1,PAF1,WDR61
roce
ss
2.99
391
833
2
regulation of muscle hypertrophy
biol
ogic
al_p CAMK2D,RGS2,GSK3A,LMCD1
roce
ss
2.99
391
833
2
positive regulation of DNA-dependent
transcription, elongation
biol
ogic
al_p SUPT5H,SUPT4H1,PAF1,WDR61
roce
ss
2.99
391
833
2
G
O:
00
34
24
3
G
O:
00
14
74
3
G
O:
00
32
78
6
092
8
7
E
0
2
3.
9
7
E
0
2
4.
0
0
E
0
2
4.
0
0
E
0
2
4.
0
0
E
0
2
G
O:
00
06
37
6
mRNA splice site selection
biol
ogic
al_p SFSWAP,CELF1,SF3A2,SRSF10
roce
ss
2.99
391
833
2
actin nucleation
biol
ogic
al_p ARPC4-TTLL3,ACTR3,WASH4P,ACTR2
roce
ss
2.99
391
833
2
B cell apoptotic process
biol
ogic
al_p NOC2L,BCL6,BCL2L11,PTEN
roce
ss
2.99
391
833
2
G
O:
00
46
63
6
negative regulation of alpha-beta T cell
activation
biol
ogic
al_p BCL6,RC3H1,GLI3,TNFRSF14
roce
ss
2.99
391
833
2
G
O:
positive regulation of cellular catabolic
process
biol
ogic
1.66
917
G
O:
00
45
01
0
G
O:
00
01
78
3
SUPT5H,SMAD7,ADAM8,PLK1,ZC3H12A,ATG4B,WAC,MDM2,NUB1,PT
EN,PHKG2,ARNT,CSNK1E,PABPC1
4.
0
0
E
0
2
4.
0
0
E
0
2
4.
0
0
E
0
2
4.
0
0
E
0
2
4.
0
00
31
33
1
G
O:
00
51
32
9
G
O:
00
06
38
3
G
O:
00
51
33
8
G
O:
00
42
32
7
al_p
roce
ss
570
7
interphase of mitotic cell cycle
biol
ogic
al_p
roce
ss
transcription from RNA polymerase III
promoter
biol
ogic
al_p GTF3C2,POLR3E,GTF3C1,TBP,ZNF76,BDP1,CRCP,TROVE2
roce
ss
regulation of transferase activity
biol
ogic
al_p
roce
ss
positive regulation of phosphorylation
CDK14,KANK2,PSMB10,BCL6,PSMB9,CEP135,USP47,PTPN6,PRKAC
A,ANAPC4,PLK1,SDCCAG8,CAMK2D,GIGYF2,PAF1,MDM2,INO80,NU
MA1,PKD2,CASP2,RB1,PAFAH1B1,SLFN11,CHMP1A,PLK2,CUL4A,PT
EN,CDK5RAP2,PSMC6,CDK6,PSMC4,DGKZ,HINFP,DBF4,SMARCA4,D
YNC1I2,PSMA1,CSNK1E,PKD1,CLASP1
ACADVL,IGF1R,RAF1,ZFP91,VAPB,XBP1,ADAM8,PTPN6,NOD1,PRKA
CA,PLK1,ASNS,HDGF,CCNL1,FAM58A,CLN8,STK4,FGFR1,ADCY4,TA
B2,SEC31A,PPM1F,CCNL2,NF1,PKD2,LMNA,RB1,MAPK8IP3,TPP1,SH
3BP5,RGS3,PTEN,IQGAP1,FBXW7,PHPT1,HERPUD1,PXN,PRKRIP1,C
SK,PTPRC,PAK1,NCK2,ACD,CSF1R,AK5,NOX4,PDIA5,MDFI,RGS2,PD
GFRB,CARD14,YIF1A,TLN1,GSK3A,IGF2,PDCD4,CRIPAK,CDK5RAP1,
NTRK1,SPRED1,TNFRSF10B,DUSP6,PKD1,PDPK1,CDK5RAP3,WNK1
ACADVL,IGF1R,RAF1,ZFP91,CNTF,VAPB,RBPMS,XBP1,ADAM8,NOD1
biol
,PRKACA,PLK1,ASNS,HDGF,TNK2,STK4,FGFR1,ADCY4,TAB2,SEC31
ogic
A,NPTN,RPS6KA5,PKD2,LMNA,MAPK8IP3,SENP2,TPP1,GRB10,FLCN,
al_p
NRP1,IQGAP1,FBXW7,HERPUD1,PXN,CSK,PTPRC,PAK1,SEMA4D,CS
roce
F1R,C3,SMAD4,ENG,NOX4,PDIA5,MDFI,ITGA5,PDGFRB,CARD14,TNF
ss
RSF14,YIF1A,TLN1,GSK3A,IGF2,NTRK1,TNFRSF10B,PKD1,PDPK1
1.32
735
295
5
2.03
360
490
5
1.23
843
139
9
1.26
098
530
7
1
E
0
2
4.
0
3
E
0
2
4.
0
4
E
0
2
4.
0
6
E
0
2
4.
0
7
E
0
2
G
O:
00
48
85
6
anatomical structure development
FZD6,PBX2,CRIP2,EIF2B4,CADM1,RAI1,PSMB10,CKB,CLMN,IGF1R,L
AMB1,NPHP3,PTS,SIRT2,UTRN,RAF1,F11R,COL9A1,CDK13,BDNF,TA
Z,SIN3B,CPE,PLCD1,SART1,COL2A1,SUPT20H,MARCH5,LUC7L,BCL6
,TBX2,PTPN22,CNTF,CUX1,FMR1,SMAD7,BMP8A,GLG1,ARHGEF12,E
HMT1,RNH1,IL15RA,CD72,TTLL3,LEF1,PAX8,EMX2,ITGA9,ADAMTS1,
BCL2L11,MEPE,XBP1,CPM,PAM,MARK4,UHMK1,ADAM8,CAPZB,PRP
F40A,CD9,SIPA1L1,KRIT1,MINK1,PDLIM5,PTPN6,ACTR3,LHX4,VASP,
CSNK2A1,PRKACA,SDCCAG8,ASNS,JAG2,DNM1L,RC3H1,CHD6,ZC3
H12A,SEPT4,POLM,SLC11A2,AAMP,LSAMP,CNP,CLN8,TBX18,JHDM1
D,BBS1,GIGYF2,FLG,STK4,FGFR1,RAB18,HSF4,DISP1,CAPRIN1,CEL
F1,PDE4D,PAF1,TAB2,SHARPIN,RNF8,KIAA0586,COL12A1,FKBP1A,P
RKCH,YY1,SSH2,THBS3,PFDN5,CREB1,NPTN,DFNA5,NF1,ZEB1,CRI
P1,NUMA1,RGMB,COL18A1,MED28,NPR1,RPS6KA5,NIPBL,PKD2,CAS
biol P2,SLC12A6,RXRB,LMNA,MITF,ITGA3,RB1,MAPK8IP3,ZFPM2,BLOC1
ogic S5,RNF168,PAFAH1B1,SENP2,IL18,MTCH1,TPP1,AACS,ARPC2,SYNE
al_p 1,EPN2,ADAM15,USP33,BICD1,HEXA,PLD6,FLCN,NRP1,TENC1,STX2,
roce VPS72,PTEN,FYN,ALDH1A3,IDH1,SRPK1,RUNX2,IQGAP1,FBXW7,SM
ss
ARCD3,IFT172,CTNS,PXN,SRGAP2,NCOR1,MEF2A,DYM,OXCT1,TTC
7A,FECH,TCTN1,SSBP1,CACNB1,MYCBP2,CLTCL1,MYLK,MAN1A2,P
BX3,RAB8A,AFF4,TRIM28,CSK,CDK5RAP2,COL9A3,PTPRS,PTPRC,S
WAP70,IMPDH1,UBP1,CDK6,RARRES2,WDR61,FLOT1,PSMC4,STAG
2,GOPC,RANBP9,WDR35,PAK1,EVC,NCK2,RAB10,SEMA6A,CTSH,TC
F4,ACD,SEMA4D,CSF1R,C3,HSD17B4,ROBO3,SS18,SMAD4,NAV1,TG
FB1I1,DDAH1,LMBR1,DTYMK,EZR,CD276,NR2C2,FLNA,RAB5A,ATP5
A1,GLI3,TMED2,SDCBP2,MAPK12,EPN1,VEZT,ENG,TCF12,ARNT,NO
X4,EXT1,ERCC1,GAA,NRBP2,STK36,SDHA,WWP1,ARHGEF7,TBCE,A
SAP1,MED6,UNC5B,MDFI,PTPRD,ITGA5,HINFP,LPCAT1,PDGFRB,CO
L8A1,DZIP1,LGALS8,EPOR,CC2D2A,FARP1,RUNX1,MKNK2,SMARCA
4,KIF13B,PTPN23,TLN1,FGF14,CD164,GSK3A,ANKRD6,ITGA11,NLGN
2,NCOR2,FPGS,SETD2,EMP1,COL13A1,IGF2,PTGIS,TROVE2,MYO1E,
ATXN3,GPHN,SOX13,STAT6,TANC1,ACIN1,PSD3,ROBO2,CACNB3,P
1.08
606
605
5
4.
1
0
E
0
2
MP22,CLIC4,CDK5RAP1,BNIP2,NTRK1,BRWD1,SMAD9,DUSP6,CTTN
BP2,TGFBR3,TMEM237,ZBTB16,EGFL8,SEPT2,PKD1,PDPK1,TSG101,
FOXC1,ACAN,STK24,SEMA4B,SSH1,CDK5RAP3,C2CD3,MMP25,EYA2
,WNK1,CLASP1,TENM4,GATA2,BCL2L2
G
O:
00
06
46
9
G
O:
00
05
08
3
G
O:
00
70
61
3
G
O:
00
06
30
6
negative regulation of protein kinase activity
biol
ogic IGF1R,PTPN6,PLK1,PPM1F,NF1,RB1,SH3BP5,RGS3,PTEN,PRKRIP1,
al_p PTPRC,RGS2,PDCD4,CRIPAK,CDK5RAP1,SPRED1,DUSP6,PDPK1,W
roce NK1
ss
1.53
281
447
5
small GTPase regulator activity
mol
ecul
ar_f
unct
ion
1.38
188
002
7
regulation of protein processing
biol
ogic
al_p GLG1,ADAM8,C2,CFB,MDM2,RHBDD1,C3
roce
ss
2.14
337
335
1
DNA methylation
biol
ogic
al_p EHMT1,USP7,PLD6,PIWIL4,SMARCA4,BAZ2A,HEMK1
roce
ss
2.14
337
335
1
RALGAPA2,MCF2L,ARHGEF12,ARHGEF25,RANBP1,KRIT1,MINK1,TB
C1D2B,TBC1D10B,TBC1D14,GIT2,PLEKHG4,PLEKHG5,NF1,ACAP2,C
YTH2,IQGAP1,SRGAP2,DENND4C,MAP4K4,ARHGAP29,SGSM3,GOP
C,TBC1D22A,RASGRF2,ARHGEF7,ASAP1,FARP1,RGL2,PSD3,DENND
6B
4.
1
2
E
0
2
4.
1
6
E
0
2
4.
1
8
E
0
2
4.
1
8
E
0
2
G
O:
00
06
30
5
G
O:
00
08
01
7
G
O:
00
30
43
3
G
O:
00
00
22
8
G
O:
00
07
DNA alkylation
biol
ogic
al_p EHMT1,USP7,PLD6,PIWIL4,SMARCA4,BAZ2A,HEMK1
roce
ss
2.14
337
335
1
microtubule binding
mol
ecul
ar_f
unct
ion
1.65
872
526
2
ER-associated protein catabolic process
biol
ogic
al_p DERL2,DNAJC10,RHBDD1,OS9,MAN1B1,AMFR
roce
ss
2.30
959
414
2
nuclear chromosome
cell
ular
_co
mpo
nent
1.39
006
567
3
smoothened signaling pathway
biol
ogic DISP1,KIAA0586,RB1,RUNX2,IFT172,TCTN1,EVC,GLI3,STK36,CC2D2
al_p A,SEPT2,C2CD3
roce
HDAC6,DYNC1I1,BCL2L11,STARD9,MARK4,PLK1,TRAF3IP1,PAFAH1
B1,MAST2,CDK5RAP2,SUN2,GAPDH,LRPPRC,CLASP1
OBFC1,CBX5,EED,CSNK2A1,PLK1,TBP,YY1,INO80,CREB1,USP3,CH
MP1A,NR1H3,RUNX2,SMARCD3,NCOR1,MEF2A,TRIM28,ACD,INO80E
,SUN2,ADD3,SIRT7,ERCC1,PHF12,NCAPD3,SMARCA4,LRPPRC,STAT
6,FOXC1,SMARCAD1
1.73
840
419
3
4.
1
8
E
0
2
4.
1
9
E
0
2
4.
2
0
E
0
2
4.
2
0
E
0
2
4.
2
0
E
22
4
G
O:
00
61
00
8
G
O:
00
40
02
9
G
O:
00
31
66
8
G
O:
00
43
16
9
ss
hepaticobiliary system development
biol
ogic
CADM1,NPHP3,ASNS,NF1,NIPBL,PKD2,AACS,FBXW7,RUNX1,SMARC
al_p
A4,FPGS,TGFBR3
roce
ss
1.73
840
419
3
regulation of gene expression, epigenetic
biol
ogic
TNRC6A,SIRT2,EED,EHMT1,UPF1,CELF1,ALKBH3,USP7,PLD6,PIWIL4
al_p
,CREBZF,SMARCA4,IGF2,BAZ2A,RRP8,HEMK1
roce
ss
1.59
675
644
4
cellular response to extracellular stimulus
biol
ogic
TNRC6A,SUPT5H,HDAC6,ASNS,NPC1,ATG4B,TBC1D14,WAC,GSDMD
al_p
,MDM2,ATG12,CHMP1A,NRBP2,ATG3,RRP8,USF1
roce
ss
1.59
675
644
4
cation binding
mol
ecul
ar_f
unct
ion
RSPRY1,LPP,DHX34,CRIP2,RAI1,PTS,SIRT2,EPHX2,UTRN,MYNN,RA
F1,ZNF131,LEPRE1,COL9A1,RBM6,ATP2B1,CPE,PLCD1,COL2A1,CAL
ML4,MARCH5,BCL6,ZNF783,ENOSF1,ZFP91,EEF2K,NLN,PGS1,SMPD
4,SMAD7,USP4,HDAC6,EHMT1,ZNF496,HGS,TYW1B,SYTL4,DGKA,SU
PT4H1,ZNF83,ITGA9,ADAMTS1,ZSCAN31,CPM,FDPS,PAM,ADAM8,R
NF220,XAF1,PCGF6,MARCH6,PDLIM5,RNF24,LHX4,STAT2,ZNF446,L
MAN2,PDE7B,JAG2,UPF1,ZNF621,RC3H1,PPP5C,PDXK,HERC2,ZC3H
12A,MIB2,POLM,PCGF1,ZNF721,ZNF397,JHDM1D,ZNF710,PLCB4,DN
1.08
387
603
1
0
2
4.
2
0
E
0
2
4.
2
2
E
0
2
4.
2
2
E
0
2
4.
2
4
E
0
2
PEP,TNK2,USP20,GIT2,FLG,STK4,ZNF142,RARS,ZNF540,MAN2C1,M
MP16,ADCY4,PDE4D,SF3A2,TAB2,SHARPIN,DPF2,NADK,IDI1,RNF8,C
YP2R1,MDM2,KCMF1,ZCCHC14,ZFYVE26,PRKCH,PPM1F,ZNF595,ID
H3G,YY1,GMEB2,THBS3,MCFD2,DDX58,ZCCHC9,LIMCH1,ZEB1,NEK3
,CRIP1,REPS1,TPM4,COL18A1,EBF1,PHF15,FKBP10,UNKL,ZNF3,RPS
6KA5,ALKBH3,ZNF837,PKD2,RXRB,GALT,MDP1,PPP2R3C,ITGA3,ZZE
F1,LTBP4,RABGGTA,GNAI1,USP3,MZF1,ZFPM2,CPPED1,RNF168,ZN
F865,EDEM2,RNF217,TPP1,CHMP1A,PDE8A,STK38L,ACAP2,ZNF558,
ANXA5,GALNT2,ADAM15,USP33,ZNF263,ZNF180,ZNF276,NR1H3,NR
P1,ZNF605,CHFR,ZNF410,PTGR2,TENC1,RPL37A,MAST2,PTEN,FYN,I
DH1,SRPK1,IQGAP1,C1R,PXN,ADAMTS18,KPNB1,ATP11B,PPP1R10,
PARN,ZMYM5,TNS1,FECH,NECAB3,PIAS2,CLSTN2,MYCBP2,MYLK,D
DX41,MAN1A2,RNF213,ZNF565,ZFAND2B,TRIM28,CP,ITPA,SWAP70,I
MPDH1,RNF146,AGBL5,EBF4,DDHD2,ZNF148,ZNF76,ARHGAP29,OG
FOD3,UBA2,SP110,PPA2,PCDH7,RHEB,ZSWIM7,TRPM7,IKZF5,DGKZ,
ZNF609,SMAD4,FNTB,CHURC1,CHURC1FNTB,ZNF114,TGFB1I1,DDAH1,LIMD2,MTRR,ZNF44,TANK,ING4,ZNF6
87,NR2C2,CA5B,C1S,GLI3,THNSL2,ADD3,NDUFV1,MAPK12,NDUFS2,
EPS15L1,B4GALT4,SIRT7,ZSCAN5A,ZNF692,PHF1,B3GAT3,STK36,AT
P8B2,DEF8,PHF12,ASAP1,CAPS2,RABGGTB,ZNF554,IDH3B,PTGR1,N
UBP1,CIZ1,ITGA5,HINFP,MAN2A2,LPCAT1,DZIP1,MAN1B1,GLIS3,NO
B1,ENO4,DBF4,CANX,RUNX1,MKNK2,TRIM41,MFI2,SUMF2,ZNF518B,
ZNF90,ZNF638,ZC4H2,PHC3,DNAJC21,LONRF3,SIK3,ITGA11,ZNF383,
EFCAB2,SETD2,PTGIS,WDFY3,AMFR,NUCB1,MOB1A,PHF21A,GPHN,
PGM2,ERI3,ZBED5,STAT6,CARS2,SLC25A24,ZNF138,ZNF705A,CDK5
RAP1,BNIP2,SHPRH,CACNA2D1,SMAD9,HBB,ZFC3H1,CACNA2D4,LI
MS2,ZBTB16,STAMBPL1,ZDHHC8,BAZ2A,SIRT3,PLOD2,EGFL8,PHF1
9,LMCD1,LETM1,THAP6,ZC3H14,ACAN,STK24,MMP25,UBR5,EYA2,P
HC2,ZC3H15,GATA2
G
O:
00
embryonic placenta development
biol
ogic
al_p
PLCD1,LEF1,STK4,PKD2,TRIM28,TMED2,ARNT,MDFI,SETD2,PKD1,G
ATA2
1.78
552
960
4.
2
5
01
89
2
G
O:
00
08
23
9
G
O:
00
70
41
1
G
O:
00
70
20
1
G
O:
00
32
35
2
roce
ss
dipeptidyl-peptidase activity
mol
ecul
ar_f
unct
ion
8
DPP4,FAP,DPP7
3.68
366
259
5
I-SMAD binding
mol
ecul
ar_f
unct
ion
SMAD7,SMAD4,TGFB1I1
3.68
366
259
5
regulation of establishment of protein
localization
biol
ogic
al_p
roce
ss
CADM1,NLRP1,SYTL4,RBPMS,PAM,UHMK1,ADAM8,PRKACA,DNM1L,
VAMP7,DISP1,MDM2,DDX58,RHBDF1,NF1,PKD2,GCC2,NR1H3,RAB8
A,CSK,GOPC,CSF1R,SMAD4,C1QTNF3,FLNA,GLI3,VAMP4,MDFI,RHB
DF2,PKD1,PDPK1,KPNA1,UBR5
1.36
379
408
7
positive regulation of hormone metabolic
process
biol
ogic
al_p IGF1R,PAX8,ARNT
roce
ss
3.67
435
431
6
E
0
2
4.
2
6
E
0
2
4.
2
6
E
0
2
4.
2
7
E
0
2
4.
2
9
E
0
2
G
O:
00
72
01
7
G
O:
00
00
05
2
G
O:
00
33
14
7
G
O:
00
46
63
9
G
O:
00
07
distal tubule development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
3.67
435
431
6
citrulline metabolic process
biol
ogic
al_p ALDH18A1,DDAH1,DDAH2
roce
ss
3.67
435
431
6
negative regulation of intracellular estrogen
receptor signaling pathway
biol
ogic
al_p KANK2,RQCD1,CRIPAK
roce
ss
3.67
435
431
6
negative regulation of alpha-beta T cell
differentiation
biol
ogic
al_p BCL6,RC3H1,GLI3
roce
ss
3.67
435
431
6
cytoskeletal anchoring at plasma membrane
biol
ogic
TLN2,EZR,TLN1
al_p
roce
3.67
435
431
6
4.
2
9
E
0
2
4.
2
9
E
0
2
4.
2
9
E
0
2
4.
2
9
E
0
2
4.
2
9
E
01
6
G
O:
00
50
88
4
G
O:
00
07
06
4
G
O:
00
71
23
6
G
O:
00
50
86
0
ss
neuromuscular process controlling posture
biol
ogic
al_p CLN8,HEXA,GAA
roce
ss
3.67
435
431
6
mitotic sister chromatid cohesion
biol
ogic
al_p NIPBL,RB1,MAU2
roce
ss
3.67
435
431
6
cellular response to antibiotic
biol
ogic
al_p MDM2,CRIP1,MEF2A
roce
ss
3.67
435
431
6
negative regulation of T cell receptor
signaling pathway
biol
ogic
al_p PTPN22,PTPN6,PHPT1
roce
ss
3.67
435
431
6
0
2
4.
2
9
E
0
2
4.
2
9
E
0
2
4.
2
9
E
0
2
4.
2
9
E
0
2
G
O:
00
46
62
1
G
O:
00
31
46
1
G
O:
00
16
66
7
G
O:
00
35
74
9
G
O:
00
42
negative regulation of organ growth
biol
ogic
al_p STK4,PTEN,GSK3A
roce
ss
3.67
435
431
6
cullin-RING ubiquitin ligase complex
cell
ular
CRBN,SPOP,USP47,ANAPC4,DCAF11,ANAPC16,DCAF8,CUL4A,FBX
_co
W7,DCAF6,DCAF17,KLHL7
mpo
nent
1.73
113
333
3
oxidoreductase activity, acting on a sulfur
group of donors
mol
ecul
ar_f
unct
ion
2.00
100
190
4
myelin sheath adaxonal region
cell
ular
_co CNP,PTEN
mpo
nent
5.59
733
110
9
GPI-anchor transamidase complex
cell
ular
GPAA1,PIGS
_co
mpo
5.59
733
110
9
DNAJC10,TXNL1,PTGES2,QSOX1,TXNDC5,P4HB,PDIA5,PDIA3
4.
2
9
E
0
2
4.
3
4
E
0
2
4.
3
9
E
0
2
4.
4
1
E
0
2
4.
4
1
E
76
5
G
O:
00
65
01
0
G
O:
00
43
23
0
G
O:
00
08
27
6
G
O:
00
45
78
6
nent
extracellular membrane-bounded organelle
cell
ular
_co LAMB1,DPP4,COL12A1,LGALS3BP,ANXA5,C3,FLNA,GAPDH,TLN1
mpo
nent
1.90
818
106
extracellular organelle
cell
ular
_co LAMB1,DPP4,COL12A1,LGALS3BP,ANXA5,C3,FLNA,GAPDH,TLN1
mpo
nent
1.90
818
106
protein methyltransferase activity
mol
ecul
ar_f
unct
ion
EED,EHMT1,PRMT10,PRMT5,NTMT1,SETD8,N6AMT1,SETD2,HEMK1
1.89
938
852
6
negative regulation of cell cycle
biol
ogic
al_p
roce
ss
PSMB10,PPP1R13B,SART1,BCL6,PSMB9,UHMK1,USP47,CSNK2A1,P
RKACA,ANAPC4,PLK1,WAC,PAF1,MDM2,PTPRK,PKD2,CASP2,RB1,C
HMP1A,PLK2,CUL4A,CHFR,PTEN,CDK5RAP2,PSMC6,CDK6,PSMC4,S
GSM3,RHEB,DGKZ,ING4,CDC14B,MAPK12,HINFP,DBF4,SMARCA4,P
DCD4,PSMA1,CDK5RAP1,RRP8,PKD1,TSG101,FOXC1,PLA2G16
1.29
714
623
6
0
2
4.
4
3
E
0
2
4.
4
3
E
0
2
4.
5
2
E
0
2
4.
5
2
E
0
2
G
O:
00
71
49
6
G
O:
00
48
87
1
G
O:
00
04
40
7
G
O:
00
42
64
5
G
O:
00
30
cellular response to external stimulus
biol
ogic TNRC6A,SUPT5H,HDAC6,ASNS,NPC1,ATG4B,TBC1D14,WAC,GSDMD
al_p ,MDM2,ATG12,CASP2,IL18,CHMP1A,LTBR,MAPK8,NRBP2,TNFRSF10
roce B,ATG3,RRP8,USF1
ss
1.48
128
420
1
multicellular organismal homeostasis
biol
ogic
ACADVL,COL9A1,COL2A1,ADAM8,SLC11A2,BBS1,GIGYF2,NF1,TPP1,
al_p
FLCN,TENC1,CSK,CTSH,CSF1R,NOX4,LPCAT1,PDGFRB,GATA2
roce
ss
1.53
485
686
6
histone deacetylase activity
mol
ecul
ar_f
unct
ion
2.50
125
238
mitochondrial nucleoid
cell
ular
_co ACADVL,SHMT2,SSBP1,LRPPRC,POLG,TFAM
mpo
nent
2.26
918
828
8
regulation of proteolysis
biol
UBXN1,SMAD7,HDAC6,RAD23A,ADAM8,PRKACA,PLK1,CLN8,WAC,M
ogic
DM2,RHBDF1,SERPINH1,NUB1,LTBP4,NR1H3,PTEN,FBXW7,CSNK1E
al_p
,C2CD3
roce
1.51
467
465
9
SIRT2,HDAC6,NCOR1,MAPK8,SIRT7
4.
5
4
E
0
2
4.
5
5
E
0
2
4.
5
5
E
0
2
4.
5
5
E
0
2
4.
5
6
E
16
2
G
O:
00
16
57
9
G
O:
00
07
03
3
G
O:
00
48
51
5
G
O:
00
31
12
4
ss
protein deubiquitination
biol
ogic
al_p USP10,USP4,USP47,USP20,USP3,USP33,USP7,USP15,ATXN3
roce
ss
1.89
458
894
4
vacuole organization
biol
ogic
al_p ATG4B,CLN8,TBC1D14,HPS4,ATG12,TPP1,HEXA,GAA,ATG3
roce
ss
1.89
458
894
4
spermatid differentiation
biol
ogic
PRKACA,SEPT4,CELF1,RNF8,RHBDD1,PAFAH1B1,PLD6,MAST2,SRP
al_p
K1,AFF4,GOPC
roce
ss
1.76
427
330
3
mRNA 3-end processing
biol
ogic
SYMPK,PAIP1,PAF1,EIF4B,PAN2,CSTF1,RQCD1,PARN,NCBP2,PABP
al_p
C1,PABPN1
roce
ss
1.76
427
330
3
0
2
4.
5
8
E
0
2
4.
5
8
E
0
2
4.
5
8
E
0
2
4.
5
8
E
0
2
G
O:
00
32
84
5
negative regulation of homeostatic process
biol
ogic
al_p FKBP1A,FLCN,CSK,ACD,ERCC1
roce
ss
2.49
493
194
3
vesicle docking involved in exocytosis
biol
ogic
al_p SYTL2,RAB8A,VPS45,SCFD1,VTI1B
roce
ss
2.49
493
194
3
NADP metabolic process
biol
ogic
al_p H6PD,FDXR,NADK,FMO2,IDH1
roce
ss
2.49
493
194
3
G
O:
00
18
14
6
keratan sulfate biosynthetic process
biol
ogic
al_p ST3GAL1,ST3GAL4,B4GALT4,ACAN,FMOD
roce
ss
2.49
493
194
3
G
O:
00
10
regulation of macromolecule biosynthetic
process
biol
ogic
al_p
roce
1.08
992
083
1
G
O:
00
06
90
4
G
O:
00
06
73
9
FZD6,OBFC1,PBX2,KANK2,EIF2B4,RAI1,IGF1R,TNRC6A,SIRT2,MYNN
,TRNAU1AP,NOC2L,ZNF131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,S
UPT5H,SUPT20H,BCL6,FUBP1,ZNF783,TBX2,MMS19,CUX1,EED,FMR
1,SMAD7,MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4
4.
5
9
E
0
2
4.
5
9
E
0
2
4.
5
9
E
0
2
4.
5
9
E
0
2
4.
6
1
E
55
6
ss
G
O:
00
31
biol
ogic HLA-DPB1,DPP4,HLAal_p DQA1,PTPN6,FYN,CSK,PAK1,LGALS8,TNFRSF14,PDPK1
roce
T cell costimulation
H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PAM,UHMK1,USP47,ADAM8
,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3A,NOD1,STAT2
,PLK1,ZNF446,PTGES2,UPF1,ZNF621,HDGF,CCNL1,CHD6,ZC3H12A,
FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,
ZNF710,GIGYF2,WAC,ZNF142,FUBP3,ZNF540,FGFR1,HSF4,PAIP1,CA
PRIN1,CELF1,PAF1,TAB2,SGK1,DPF2,RNF8,MDM2,PRKCH,PPM1F,Z
NF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,SRP9,FLII,RPRD1A,DD
X58,CCNL2,PTPRK,ZEB1,EIF4B,IFITM3,ASCC2,RGMB,EBF1,MED28,Z
NF3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PR
MT5,MZF1,ZFPM2,TP53BP1,RNF168,ZNF865,SENP2,IL18,PUM2,SUB1
,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GR
B10,USP7,FLCN,ZNF605,ZNF410,SAP30BP,MAST2,VPS72,PTEN,RUN
X2,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,MEF2A,FECH,SET
D8,NECAB3,PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX3,ZNF565,AB
CA2,AFF4,TRIM28,DMTF1,CDK5RAP2,UBP1,WDR61,EBF4,ZNF148,ZN
F76,STAG2,SP110,NCK2,TCF4,ACD,IKZF5,HMGN2,SEMA4D,SSBP2,E
RC1,NFYC,PIWIL4,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,ZNF44,CREBZF,ING4,CD276,Z
NF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,MAPK12,CCDC59,DC
AF6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZNF692,GAPDH,PHF1,
STK36,WWP1,PHF12,MED6,MDFI,CIRBP,ZNF554,CIZ1,RGS2,HINFP,N
CBP2,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,MKNK2
,SMARCA4,NAA16,LRPPRC,RAD54L2,ZNF518B,ZNF90,ZNF638,PER3,
GSK3A,ZNF383,NCOR2,SETD2,IGF2,PTGIS,ATXN3,PSTK,PHF21A,PD
CD4,SOX13,CHD2,STAT6,ZNF138,ZNF705A,NTRK1,TFAM,BRWD1,SM
AD9,TGFBR3,ZBTB16,BAZ2A,RRP8,VARS,LARS,PHF19,LMCD1,PKD1,
PDPK1,TSG101,USF1,FOXC1,CDK5RAP3,PABPC1,EYA2,SMARCAD1,
CC2D1A,GATA2
0
2
1.82
062
601
3
4.
6
1
E
29
5
G
O:
00
05
76
5
G
O:
00
06
47
9
G
O:
00
08
21
3
G
O:
00
04
66
3
ss
lysosomal membrane
cell
ular HLA-DPB1,HLA-DQA1,NPC1,SLC11A2,VAMP7,HLA_co DMB,TPCN2,IFITM3,CTNS,ABCA2,HGSNAT,MCOLN1,GAA,CD164,CC
mpo Z1B,CD63
nent
1.57
671
298
9
protein methylation
biol
ogic
EED,EHMT1,PRMT10,PRMT5,NTMT1,SETD8,N6AMT1,WDR61,PHF1,S
al_p
ETD2,BAZ2A,PHF19,HEMK1
roce
ss
1.66
804
021
3
protein alkylation
biol
ogic
EED,EHMT1,PRMT10,PRMT5,NTMT1,SETD8,N6AMT1,WDR61,PHF1,S
al_p
ETD2,BAZ2A,PHF19,HEMK1
roce
ss
1.66
804
021
3
Rab geranylgeranyltransferase activity
mol
ecul
ar_f
unct
ion
5.40
270
514
RABGGTA,RABGGTB
0
2
4.
6
7
E
0
2
4.
6
9
E
0
2
4.
6
9
E
0
2
4.
7
1
E
0
2
G
O:
00
03
92
3
G
O:
00
15
35
5
G
O:
00
00
90
0
G
O:
00
05
38
1
G
O:
00
35
GPI-anchor transamidase activity
mol
ecul
ar_f
unct
ion
GPAA1,PIGS
5.40
270
514
secondary active monocarboxylate
transmembrane transporter activity
mol
ecul
ar_f
unct
ion
SLC16A3,SLC16A1
5.40
270
514
translation repressor activity, nucleic acid
binding
mol
ecul
ar_f
unct
ion
ZNF540,CELF1
5.40
270
514
iron ion transmembrane transporter activity
mol
ecul
ar_f
unct
ion
SLC25A37,SLC11A2
5.40
270
514
histone deacetylase regulator activity
mol
ecul
ar_f
unct
NCOR1,MAPK8
5.40
270
514
4.
7
1
E
0
2
4.
7
1
E
0
2
4.
7
1
E
0
2
4.
7
1
E
0
2
4.
7
1
E
03
3
G
O:
00
05
12
7
G
O:
00
34
45
2
G
O:
00
19
20
4
G
O:
00
61
38
3
ion
ciliary neurotrophic factor receptor binding
mol
ecul
ar_f
unct
ion
CNTF,LIFR
5.40
270
514
dynactin binding
mol
ecul
ar_f
unct
ion
PAFAH1B1,BICD1
5.40
270
514
nucleotide phosphatase activity
mol
ecul
ar_f
unct
ion
PNKP,NTPCR
5.40
270
514
trabecula morphogenesis
biol
ogic
al_p ADAMTS1,FKBP1A,THBS3,SEMA4D,SMARCA4,TGFBR3
roce
ss
2.24
543
874
9
0
2
4.
7
1
E
0
2
4.
7
1
E
0
2
4.
7
1
E
0
2
4.
7
3
E
0
2
G
O:
00
06
50
5
G
O:
00
32
43
6
G
O:
00
22
40
6
G
O:
00
01
55
4
G
O:
00
71
GPI anchor metabolic process
biol
ogic
al_p GPAA1,PIGS,PIGG,PIGN,PIGO,ALG9
roce
ss
2.24
543
874
9
positive regulation of proteasomal ubiquitindependent protein catabolic process
biol
ogic
al_p SMAD7,PLK1,MDM2,NUB1,PTEN,CSNK1E
roce
ss
2.24
543
874
9
membrane docking
biol
ogic
al_p SYTL2,RAB8A,VPS45,EZR,SCFD1,VTI1B
roce
ss
2.24
543
874
9
luteolysis
biol
ogic
al_p CASP2,ROBO2
roce
ss
5.38
905
299
7
ribonucleoprotein complex localization
biol
ogic
TGS1,SDAD1
al_p
roce
5.38
905
299
7
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
16
6
G
O:
00
03
03
2
G
O:
19
01
09
9
G
O:
00
48
17
0
G
O:
00
46
66
8
ss
detection of oxygen
biol
ogic
al_p SLC11A2,ENG
roce
ss
5.38
905
299
7
negative regulation of signal transduction in
absence of ligand
biol
ogic
al_p FYN,UNC5B
roce
ss
5.38
905
299
7
positive regulation of long-term neuronal
synaptic plasticity
biol
ogic
al_p BDNF,NPTN
roce
ss
5.38
905
299
7
regulation of retinal cell programmed cell
death
biol
ogic
al_p BDNF,CNTF
roce
ss
5.38
905
299
7
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
G
O:
00
70
12
0
ciliary neurotrophic factor-mediated
signaling pathway
biol
ogic
al_p CNTF,LIFR
roce
ss
5.38
905
299
7
negative regulation of macroautophagy
biol
ogic
al_p NPC1,NRBP2
roce
ss
5.38
905
299
7
NADPH oxidation
biol
ogic
al_p FDXR,FMO2
roce
ss
5.38
905
299
7
G
O:
00
71
21
8
cellular response to misfolded protein
biol
ogic
al_p HDAC6,ATXN3
roce
ss
5.38
905
299
7
G
O:
00
71
cellular response to parathyroid hormone
stimulus
biol
ogic
PRKACA,IL18
al_p
roce
5.38
905
299
7
G
O:
00
16
24
2
G
O:
00
70
99
5
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
37
4
G
O:
00
48
24
0
G
O:
00
97
03
4
G
O:
00
06
45
1
G
O:
00
42
40
7
ss
sperm capacitation
biol
ogic
al_p PRKACA,SEPT4
roce
ss
5.38
905
299
7
mitochondrial respiratory chain complex IV
biogenesis
biol
ogic
al_p COX14,BCS1L
roce
ss
5.38
905
299
7
translational readthrough
biol
ogic
al_p TRNAU1AP,PSTK
roce
ss
5.38
905
299
7
cristae formation
biol
ogic
al_p TAZ,LETM1
roce
ss
5.38
905
299
7
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
G
O:
00
34
98
3
peptidyl-lysine deacetylation
biol
ogic
al_p HDAC6,SIRT3
roce
ss
5.38
905
299
7
axon midline choice point recognition
biol
ogic
al_p ROBO3,ROBO2
roce
ss
5.38
905
299
7
mitochondrial respiratory chain complex IV
assembly
biol
ogic
al_p COX14,BCS1L
roce
ss
5.38
905
299
7
G
O:
00
01
51
4
selenocysteine incorporation
biol
ogic
al_p TRNAU1AP,PSTK
roce
ss
5.38
905
299
7
G
O:
00
90
cytoskeletal anchoring at nuclear
membrane
biol
ogic
SYNE1,SUN2
al_p
roce
5.38
905
299
7
G
O:
00
16
19
9
G
O:
00
33
61
7
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
28
6
G
O:
00
21
86
1
G
O:
00
72
23
6
G
O:
00
90
04
2
G
O:
20
01
24
0
ss
forebrain radial glial cell differentiation
biol
ogic
al_p LEF1,GLI3
roce
ss
5.38
905
299
7
metanephric loop of Henle development
biol
ogic
al_p PKD2,PKD1
roce
ss
5.38
905
299
7
tubulin deacetylation
biol
ogic
al_p SIRT2,HDAC6
roce
ss
5.38
905
299
7
negative regulation of extrinsic apoptotic
signaling pathway in absence of ligand
biol
ogic
al_p FYN,UNC5B
roce
ss
5.38
905
299
7
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
G
O:
00
07
02
3
G
O:
00
90
14
0
G
O:
00
32
87
6
G
O:
00
10
39
0
G
O:
00
45
post-chaperonin tubulin folding pathway
biol
ogic
al_p TBCD,TBCE
roce
ss
5.38
905
299
7
regulation of mitochondrial fission
biol
ogic
al_p MARCH5,DNM1L
roce
ss
5.38
905
299
7
negative regulation of DNA
endoreduplication
biol
ogic
al_p FBXW7,STAG2
roce
ss
5.38
905
299
7
histone monoubiquitination
biol
ogic
al_p PCGF1,WAC,PAF1,RNF168
roce
ss
2.83
634
368
3
thymic T cell selection
biol
ogic
MINK1,JAG2,PTPRC,GLI3
al_p
roce
2.83
634
368
3
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
3
E
0
2
4.
7
7
E
0
2
4.
7
7
E
06
1
G
O:
00
09
30
3
G
O:
00
43
98
4
G
O:
00
44
40
3
G
O:
00
44
41
9
ss
rRNA transcription
biol
ogic
al_p GTF3C2,GTF3C1,RNASEK,SIRT7
roce
ss
2.83
634
368
3
histone H4-K16 acetylation
biol
ogic
al_p PHF15,ING4,MSL1,KANSL3
roce
ss
2.83
634
368
3
symbiosis, encompassing mutualism
through parasitism
biol
ogic
al_p
roce
ss
PSMB10,F11R,CDK13,CBX5,VAPB,NUP98,ATP6V1D,VRK2,LEF1,HLAC,PSMB9,BCL2L11,FDPS,RAD23A,STAT2,MDM2,TBP,CREB1,DDX58,I
FITM3,RB1,BICD1,USP7,CUL4A,FYN,SRPK1,FBXW7,KPNB1,LTBR,SP
110,ATP6V0A1,KLC1,THOC2,SLC25A6,WWP1,ITGA5,TNFRSF14,SMA
RCA4,RPLP0,DYNC1I2,TSG101,KPNA1,PABPN1
1.29
602
505
interspecies interaction between organisms
biol
ogic
al_p
roce
ss
PSMB10,F11R,CDK13,CBX5,VAPB,NUP98,ATP6V1D,VRK2,LEF1,HLAC,PSMB9,BCL2L11,FDPS,RAD23A,STAT2,MDM2,TBP,CREB1,DDX58,I
FITM3,RB1,BICD1,USP7,CUL4A,FYN,SRPK1,FBXW7,KPNB1,LTBR,SP
110,ATP6V0A1,KLC1,THOC2,SLC25A6,WWP1,ITGA5,TNFRSF14,SMA
RCA4,RPLP0,DYNC1I2,TSG101,KPNA1,PABPN1
1.29
602
505
0
2
4.
7
7
E
0
2
4.
7
7
E
0
2
4.
7
8
E
0
2
4.
7
8
E
0
2
G
O:
00
30
17
3
G
O:
00
06
95
0
integral to Golgi membrane
cell
ular
_co ST3GAL1,CUX1,QSOX1,ST3GAL4,GALNT2,ST6GALNAC5,PCSK7
mpo
nent
response to stress
FZD6,USP10,ACADVL,EIF2B4,CADM1,PSMB10,IGF1R,TNRC6A,EPHX
2,PPIL2,RAF1,NLRP1,GP1BB,F11R,SLC16A3,BDNF,ATP2B1,CBX5,SU
PT5H,HLADPB1,DPP4,BCL6,TBX2,PTPN22,MMS19,GBP3,PLD1,VAPB,SMAD7,H
DAC6,VRK2,DERL2,DGKA,PNKP,HLAC,PSMB9,BCL2L11,XYLT1,XBP1,PAM,HLADQA1,RAD23A,APITD1,USP47,ADAM8,POLR3E,CAPZB,DNAJC10,XAF
1,CD9,MINK1,PTPN6,IGBP1,NOD1,PRKACA,STAT2,DHX9,PLK1,ASNS,
UPF1,HDGF,NPC1,HERC2,POLM,SLC11A2,ATG4B,CLN8,BCLAF1,CA
MK2D,SLC16A1,JAM2,TBC1D14,WAC,SIKE1,HPS4,HSF4,C2,CFB,PMS
biol 1,TAB2,SGK1,SHARPIN,RNF8,SEC31A,MDM2,RHBDD1,ZFYVE26,PRK
ogic CH,YY1,INO80,CREB1,DDX58,LCP2,PTPRK,SERPINH1,NF1,NUB1,IFI
al_p TM3,LGALS3BP,ATG12,TPM4,RPS6KA5,NIPBL,ALKBH3,ADSL,PKD2,C
roce ASP2,SLC12A6,LMNA,ITGA3,MAPK8IP3,GNAI1,USP3,ZFPM2,TP53BP
ss
1,RNF168,PAFAH1B1,EDEM2,IL18,ESAM,SLFN11,CALCOCO2,TPP1,A
ACS,ANXA5,ADAM15,MUM1,NR1H3,USP7,FLCN,NRP1,CUL4A,FAP,PT
EN,FYN,IDH1,SRPK1,C1R,FBXW7,LGMN,HERPUD1,IKBKB,PXN,LTBR,
NCOR1,MEF2A,OXCT1,FECH,SETD8,MAPK8,MYLK,DDX41,HLAF,TRIM28,MAP4K4,CSK,PTPRC,PSMC6,IMPDH1,CDK6,ZNF148,PSMC
4,PAK1,VPS45,ZSWIM7,ACD,CSF1R,OS9,DGKZ,C3,ALDH3B1,SMAD4,
KLC1,C1QTNF3,TGFB1I1,INO80E,TANK,ING4,CD276,CDC14B,SLC23A
2,APOL3,FLNA,RAB5A,IRF9,C1S,MAPK12,NDUFS2,ENG,SCFD1,ARNT
,NOX4,GAPDH,ERCC1,PHF1,NRBP2,SLC25A6,PDIA5,MDFI,CIRBP,ITG
A5,HINFP,PDGFRB,RAD51B,DIABLO,RAP1B,RUNX1,YIF1A,CRCP,TLN
1,FGF14,DOCK8,GSK3A,POLG,PTGIS,ATXN3,AMFR,PHF21A,PDCD4,
2.08
411
264
7
4.
8
0
E
0
2
1.09
971
437
6
4.
8
1
E
0
2
PSMA1,CSNK1E,NSMCE4A,NTRK1,SHPRH,SPRED1,TNFRSF10B,AT
G3,SMAD9,HBB,DUSP6,TGFBR3,PLOD2,RRP8,LUC7L3,PDPK1,USF1,
STK24,CD63,MMP25,UBR5,EYA2,SMARCAD1,GATA2
G
O:
00
08
28
5
G
O:
00
30
17
8
G
O:
00
51
16
9
G
O:
00
72
00
1
KANK2,CLMN,RAF1,LEPRE1,GAS8,BDNF,BCL6,HGS,ADAMTS1,CD9,
KRIT1,PTPN6,RC3H1,STK4,PTPRK,DFNA5,NF1,ZEB1,COL18A1,NPR1,
PKD2,RB1,FLCN,CUL4A,TENC1,IGFBP6,PTEN,FBXW7,MEF2A,CSK,C
DK6,PAK1,NCK2,SMAD4,TGFB1I1,ING4,CD276,ATP5A1,GLI3,ENG,NO
X4,TNFRSF14,CD164,PPAP2A,PMP22,NTRK1,TGFBR3,ZBTB16,TSG1
01,GATA2
negative regulation of cell proliferation
biol
ogic
al_p
roce
ss
negative regulation of Wnt receptor
signaling pathway
biol
ogic
FZD6,NPHP3,LEF1,TBX18,STK4,PFDN5,G3BP1,GRB10,GLI3,BICC1,M
al_p
DFI,GSK3A,ANKRD6,CSNK1E
roce
ss
1.62
600
737
nuclear transport
biol
ogic
al_p
roce
ss
NOC2L,BCL6,NUP98,RBPMS,UHMK1,DDX39A,KPNA6,UPF3A,PRKAC
A,NUTF2,UPF1,FYTTD1,MDM2,DDX58,NF1,PKD2,LMNA,KPNB1,PPP1
R10,SRSF10,SMAD4,C1QTNF3,FLNA,GLI3,THOC2,MDFI,NCBP2,MLX,
TGS1,SDAD1,PDIA3,PKD1,KPNA1,UBR5,PABPN1
1.33
581
342
renal system development
biol
ogic NPHP3,BDNF,SMAD7,PAX8,EMX2,ADAMTS1,BCL2L11,TBX18,FGFR1,
al_p NF1,NIPBL,PKD2,FLCN,TENC1,IQGAP1,MEF2A,CTSH,SMAD4,GLI3,P
roce DGFRB,MYO1E,ROBO2,SMAD9,ZBTB16,PKD1,FOXC1
ss
1.40
678
090
3
1.26
860
946
3
4.
8
2
E
0
2
4.
8
3
E
0
2
4.
8
5
E
0
2
4.
8
7
E
0
2
G
O:
00
30
03
1
G
O:
00
30
15
5
G
O:
00
35
10
2
G
O:
00
70
82
2
G
O:
00
16
cell projection assembly
biol
ogic TTLL3,CAPZB,ACTR3,BBS1,SSH2,IFT172,PXN,SRGAP2,MYLK,RAB8A
al_p ,WDR35,NCK2,FLNA,RAB5A,STK36,ARHGEF7,NUP85,DZIP1,CC2D2A,
roce TMEM237,SEPT2,SSH1,C2CD3
ss
1.44
125
836
regulation of cell adhesion
biol
ogic LAMB1,UTRN,DPP4,BCL6,SMAD7,LEF1,HSD17B12,ADAM8,MINK1,JA
al_p G2,TBX18,JAM2,PPM1F,NF1,PLEKHA2,IL18,ARPC2,CYTH2,FLCN,PTE
roce N,PTPRC,TBCD,CDK6,ABI3BP,ENG,COL8A1,CD164,ATXN3
ss
1.38
688
863
9
PRC1 complex
cell
ular
_co PCGF6,PHC3,PHC2
mpo
nent
3.49
833
194
3
Sin3-type complex
cell
ular
_co CSNK2A1,NCOR1,PHF12
mpo
nent
3.49
833
194
3
Sin3 complex
cell
ular
CSNK2A1,NCOR1,PHF12
_co
mpo
3.49
833
194
3
4.
8
8
E
0
2
4.
8
9
E
0
2
4.
9
2
E
0
2
4.
9
2
E
0
2
4.
9
2
E
58
0
G
O:
00
06
41
4
G
O:
00
40
01
2
G
O:
00
31
29
4
G
O:
00
30
66
6
nent
translational elongation
biol
ogic
TRNAU1AP,EEF2K,EEF1A1,RNF8,SRP9,RPL27,RPL9,RNF168,RPL24,
al_p
RPL37A,RPL4,RPLP0,PSTK,VARS,LARS
roce
ss
1.59
125
580
6
regulation of locomotion
biol
ogic
al_p
roce
ss
1.28
868
658
6
lymphocyte costimulation
biol
ogic
HLA-DPB1,DPP4,HLAal_p
DQA1,PTPN6,FYN,CSK,PAK1,LGALS8,TNFRSF14,PDPK1
roce
ss
1.79
635
099
9
endocytic vesicle membrane
cell
ular RAB34,HLA-DPB1,HLA-C,HLA_co DQA1,VAMP7,CAMK2D,MDM2,RAB31,EPN2,HLAmpo F,RAB8A,RAB10,ATP6V0A1
nent
1.65
375
691
9
IGF1R,LAMB1,RAF1,SMAD7,HDAC6,LEF1,NISCH,ADAM8,KRIT1,MINK
1,JAG2,AAMP,SGK1,PPM1F,DDX58,PTPRK,NF1,IFITM3,COL18A1,LM
NA,NEXN,FLCN,NRP1,PTEN,PHPT1,SRGAP2,MYLK,PTPRC,CDK6,RA
RRES2,SEMA6A,CTSH,SEMA4D,CSF1R,SUN2,ENG,NOX4,PDGFRB,E
LP6,ROBO2,CLIC4,TGFBR3,PDPK1,STK24
0
2
4.
9
2
E
0
2
4.
9
4
E
0
2
4.
9
8
E
0
2
5.
0
0
E
0
2
G
O:
00
07
05
9
chromosome segregation
biol
ogic
MMS19,APITD1,INO80,NIPBL,RB1,CHMP1A,NTMT1,SRPK1,FBXW7,C
al_p
DK5RAP2,DSN1,NUP37,STAG2,CENPT,NCAPD3,MAU2,SMARCAD1
roce
ss
1.53
714
598
9
negative regulation of phosphorylation
biol
ogic IGF1R,SMAD7,DNAJC10,PTPN6,PLK1,PPM1F,NF1,RB1,SH3BP5,RGS
al_p 3,GRB10,PTEN,PRKRIP1,PTPRC,SEMA4D,ENG,RGS2,PDCD4,CRIPA
roce K,CDK5RAP1,SPRED1,DUSP6,PDPK1,WNK1
ss
1.42
441
929
4
negative regulation of protein
phosphorylation
biol
ogic IGF1R,SMAD7,DNAJC10,PTPN6,PLK1,PPM1F,NF1,RB1,SH3BP5,RGS
al_p 3,PTEN,PRKRIP1,PTPRC,SEMA4D,ENG,RGS2,PDCD4,CRIPAK,CDK5
roce RAP1,SPRED1,DUSP6,PDPK1,WNK1
ss
1.43
458
586
7
G
O:
00
60
35
0
endochondral bone morphogenesis
biol
ogic
al_p COL9A1,COL2A1,THBS3,RUNX2,MEF2A,EVC,COL13A1
roce
ss
2.05
018
320
6
G
O:
00
33
regulation of intracellular steroid hormone
receptor signaling pathway
biol
ogic
KANK2,HDAC6,RQCD1,PIAS2,PAK1,SMARCA4,CRIPAK
al_p
roce
2.05
018
320
6
G
O:
00
42
32
6
G
O:
00
01
93
3
5.
0
2
E
0
2
5.
0
3
E
0
2
5.
0
9
E
0
2
5.
1
4
E
0
2
5.
1
4
E
14
3
G
O:
00
30
13
3
G
O:
00
30
49
6
G
O:
00
65
00
9
ss
transport vesicle
cell
ular CPE,HLA-DPB1,SYTL4,HLA-C,YIPF1,HLA_co DQA1,VAMP7,SEC31A,MCFD2,BLOC1S5,SYTL2,CLTCL1,HLAmpo F,CLTB,GOPC,SEC31B
nent
1.55
481
419
7
midbody
cell
ular
PLK1,TTC19,ERH,RNF8,ZFYVE26,GNAI1,FLCN,IQGAP1,CLIC4,SEPT2,
_co
SSH1
mpo
nent
1.72
951
242
1
regulation of molecular function
FZD6,CRBN,RAB3GAP2,ACADVL,EIF2B4,PSMB10,IGF1R,PTS,MYO1D
,UTRN,RALGAPA2,RAF1,NLRP1,BCL6,ZFP91,VAPB,SMAD7,MCF2L,H
DAC6,ARHGEF12,RNH1,LEF1,PSMB9,ARHGEF25,RGL4,BCL2L13,BCL
2L11,STARD13,XBP1,USP47,ADAM8,DNAJC10,RANBP1,SIPA1L1,KRI
T1,MINK1,PTPN6,CSNK2A1,IGBP1,NOD1,PRKACA,ANAPC4,PLK1,AS
biol NS,TBC1D2B,HDGF,CCNL1,HERC2,ZC3H12A,TBC1D10B,SLC11A2,FA
ogic M58A,CLN8,CAMK2D,TBC1D14,TNK2,GIT2,STK4,FGFR1,MMP16,ADC
al_p Y4,TAB2,SGK1,PLEKHG4,SEC31A,MDM2,FKBP1A,PRKCH,PPM1F,FA
roce M13A,CREB1,RALGPS2,PLEKHG5,DDX58,ZCCHC9,CCNL2,SNX13,SE
ss
RPINH1,NF1,RTKN,RPS6KA5,PKD2,LMNA,RB1,MAPK8IP3,TP53BP1,P
AFAH1B1,SENP2,MTCH1,TPP1,SYTL2,ACAP2,ANXA5,SH3BP5,BICD1,
RGS3,NR1H3,CYTH2,USP7,NRP1,ARHGAP9,PTEN,IQGAP1,FBXW7,P
HPT1,SMARCD3,HERPUD1,IKBKB,RQCD1,PXN,SRGAP2,NCOR1,PPP
1R10,MEF2A,PRKRIP1,SSBP1,MAPK8,DENND4C,MAP4K4,CSK,PTPR
C,OAZ1,PSMC6,TBCD,PSMC4,ARHGAP29,SGSM3,UBA2,GOPC,PAK1,
1.11
310
705
1
0
2
5.
2
0
E
0
2
5.
2
0
E
0
2
5.
2
3
E
0
2
NCK2,LEPR,MTMR9,CTSH,ACD,SEMA4D,CSF1R,ERC1,DGKZ,C3,SM
AD4,GRPEL2,TBC1D22A,CREBZF,CDC14B,LRPAP1,FLNA,TMED2,RA
SGRF2,AK5,ENG,NOX4,STK36,ARHGEF7,PDIA5,ASAP1,MDFI,RGS2,P
DGFRB,CARD14,DIABLO,FARP1,DBF4,SMARCA4,YIF1A,TLN1,DOCK8
,GSK3A,NLGN2,IGF2,PTGIS,PDCD4,RGL2,CRIPAK,PSMA1,PSD3,CDK
5RAP1,BNIP2,NTRK1,SPRED1,TNFRSF10B,LMF1,DUSP6,TGFBR3,CP
AMD8,SEPT2,PKD1,PDPK1,FOXC1,CDK5RAP3,RAPGEF6,WNK1,DEN
ND6B
G
O:
00
08
30
5
G
O:
00
31
32
6
integrin complex
cell
ular
_co ITGA9,ITGA3,ITGB5,ITGA5,ITGA11
mpo
nent
regulation of cellular biosynthetic process
FZD6,OBFC1,PBX2,KANK2,ACADVL,EIF2B4,RAI1,IGF1R,TNRC6A,SIR
T2,MYNN,TRNAU1AP,NOC2L,RAF1,ZNF131,RSC1A1,SFSWAP,CDK13
,SIN3B,CBX5,SUPT5H,SUPT20H,BCL6,FUBP1,ZNF783,TBX2,MMS19,
CUX1,EED,FMR1,SMAD7,MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,LEF
1,PAX8,SUPT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PAM,UHMK1,
USP47,ADAM8,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3
biol A,NOD1,STAT2,PLK1,ZNF446,PTGES2,UPF1,ZNF621,HDGF,CCNL1,C
ogic HD6,ZC3H12A,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZN
al_p F397,JHDM1D,ZNF710,GIGYF2,WAC,ZNF142,FUBP3,ZNF540,FGFR1,
roce HSF4,PAIP1,CAPRIN1,CELF1,PAF1,TAB2,SGK1,DPF2,RNF8,MDM2,P
ss
RKCH,PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,SRP9,F
LII,RPRD1A,DDX58,CCNL2,PTPRK,NF1,ZEB1,EIF4B,IFITM3,ASCC2,R
GMB,EBF1,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,
RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,RNF168,ZNF86
5,SENP2,PUM2,SUB1,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF180,BICD
1,ZNF276,NR1H3,GRB10,USP7,FLCN,ZNF605,ZNF410,SAP30BP,MAS
T2,VPS72,PTEN,RUNX2,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCO
2.41
264
272
5.
2
3
E
0
2
1.08
421
401
1
5.
2
7
E
0
2
R1,MEF2A,FECH,SETD8,SMEK1,NECAB3,PIAS2,MAPK8,MYCBP2,US
P15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,U
BP1,WDR61,EBF4,ZNF148,ZNF76,STAG2,SP110,NCK2,TCF4,ACD,IKZ
F5,HMGN2,SEMA4D,SSBP2,ERC1,C3,NFYC,PIWIL4,SRSF10,SS18,RC
OR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,DDAH1,INO80E,ZNF44,CRE
BZF,ING4,CD276,ZNF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,M
APK12,CCDC59,DCAF6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZN
F692,GAPDH,PHF1,STK36,WWP1,PHF12,MED6,MDFI,CIRBP,ZNF554,
CIZ1,RGS2,HINFP,NCBP2,LPCAT1,MLX,PDGFRB,TGS1,CDK11A,GLIS
3,ELP6,BDP1,RUNX1,MKNK2,SMARCA4,NAA16,LRPPRC,RAD54L2,ZN
F518B,ZNF90,ZNF638,PER3,GSK3A,ZNF383,NCOR2,SETD2,IGF2,PTG
IS,ATXN3,PSTK,PHF21A,PDCD4,SOX13,CHD2,STAT6,ZNF138,ZNF70
5A,NTRK1,TFAM,BRWD1,SMAD9,HBB,TGFBR3,ZBTB16,BAZ2A,RRP8,
VARS,LARS,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,DDAH
2,CDK5RAP3,PABPC1,EYA2,SMARCAD1,CC2D1A,GATA2
G
O:
00
45
21
6
cell-cell junction organization
biol
ogic
CADM1,F11R,SMAD7,CD9,PRKACA,PRKCH,PPM1F,TLN2,PTPRK,FLC
al_p
N,PTEN,PXN,CSK,TBCD,PARD6G,CSF1R,TLN1,NLGN2,PDPK1
roce
ss
1.48
825
591
5
G
O:
20
01
23
5
positive regulation of apoptotic signaling
pathway
biol
ogic
al_p BCL2L11,DNM1L,SEPT4,BCLAF1,LTBR,MAPK8
roce
ss
2.18
475
121
5
G
O:
pathway-restricted SMAD protein
phosphorylation
biol
ogic
2.18
475
SMAD7,RBPMS,USP15,SMAD4,ENG,TGFBR3
5.
2
8
E
0
2
5.
3
1
E
0
2
5.
3
00
60
38
9
G
O:
19
01
80
0
G
O:
00
05
79
5
G
O:
00
30
33
4
G
O:
00
43
40
9
al_p
roce
ss
121
5
positive regulation of proteasomal protein
catabolic process
biol
ogic
al_p SMAD7,PLK1,MDM2,NUB1,PTEN,CSNK1E
roce
ss
2.18
475
121
5
Golgi stack
cell
ular
ST3GAL1,ST3GAL4,GOLGA8B,GOLGA8A,GALNT2,NECAB3,NSFL1C,F
_co
UT4,TMED3,GOLPH3,TMED2,B4GALT4,SCFD1
mpo
nent
1.63
885
820
8
regulation of cell migration
biol
ogic
al_p
roce
ss
IGF1R,LAMB1,SMAD7,HDAC6,LEF1,NISCH,ADAM8,KRIT1,MINK1,JAG
2,AAMP,SGK1,PPM1F,DDX58,PTPRK,NF1,COL18A1,LMNA,NEXN,FLC
N,NRP1,PTEN,SRGAP2,MYLK,PTPRC,RARRES2,SEMA6A,CTSH,SEM
A4D,CSF1R,SUN2,ENG,NOX4,PDGFRB,ELP6,CLIC4,TGFBR3,PDPK1,
STK24
1.30
380
314
5
negative regulation of MAPK cascade
biol
ogic
IGF1R,PTPN6,IGBP1,NF1,PAFAH1B1,RGS3,FLCN,NCOR1,CSK,RGS2,
al_p
PDCD4,SPRED1,DUSP6
roce
ss
1.63
686
189
2
1
E
0
2
5.
3
1
E
0
2
5.
3
1
E
0
2
5.
3
2
E
0
2
5.
3
2
E
0
2
regulation of localization
CRBN,CADM1,IGF1R,LAMB1,UTRN,RALGAPA2,RAF1,NLRP1,SEPT5,
RSC1A1,BCL6,NUP98,SMAD7,HDAC6,SYTL4,LEF1,PAX8,RBPMS,NIS
CH,PAM,UHMK1,ADAM8,KRIT1,MINK1,IGBP1,PRKACA,JAG2,DNM1L,
ZC3H12A,NUP210,AAMP,VAMP7,CAMK2D,TNK2,TPCN2,DISP1,SNCAI
P,SGK1,MDM2,RHBDD1,FKBP1A,PPM1F,CREB1,DDX58,PTPRK,RHB
biol DF1,NF1,COL18A1,NPR1,CAPN10,PKD2,LMNA,RSL1D1,RB1,NEXN,A
ogic ACS,BICD1,GCC2,NR1H3,GRB10,FLCN,NRP1,PTEN,IQGAP1,FBXW7,
al_p PHPT1,IKBKB,SNX17,SRGAP2,NCOR1,OXCT1,CACNB1,MAPK8,MYC
roce BP2,CLTCL1,MYLK,ABCA2,RAB8A,CSK,PTPRC,TMEM66,CDK6,RARR
ss
ES2,NUP37,AAK1,GOPC,LEPROT,SEMA6A,CTSH,SEMA4D,CSF1R,C3
,SMAD4,C1QTNF3,FLNA,RAB5A,SUN2,GLI3,ENG,SCFD1,NOX4,SLC25
A6,VAMP4,MDFI,NUP85,NCBP2,PDGFRB,ELP6,RAP1B,RUNX1,RHBD
F2,FGF14,GSK3A,NLGN2,CACNB3,CLIC4,CACNA2D1,TGFBR3,CACN
A2D4,SPCS3,SEPT2,PKD1,PDPK1,KPNA1,STK24,CD63,UBR5,WNK1,
GATA2
nucleus organization
biol
ogic
al_p NUP98,NUMA1,LMNA,PAFAH1B1,SYNE1,SRPK1,GOPC,SUN2
roce
ss
1.92
466
178
5
G
O:
00
31
43
4
mitogen-activated protein kinase kinase
binding
mol
ecul
ar_f
unct
ion
RAF1,IGBP1,MAPK8IP3
3.37
669
071
2
G
Notch binding
mol
JAG2,AAK1,NCOR2
3.37
G
O:
00
32
87
9
G
O:
00
06
99
7
1.14
490
750
4
5.
3
3
E
0
2
5.
3
4
E
0
2
5.
3
8
E
0
2
5.
O:
00
05
11
2
G
O:
00
50
43
1
G
O:
00
46
62
0
G
O:
00
09
26
3
G
O:
00
55
05
ecul
ar_f
unct
ion
669
071
2
transforming growth factor beta binding
mol
ecul
ar_f
unct
ion
regulation of organ growth
biol
ogic
al_p TBX2,BCL2L11,STK4,FGFR1,PTEN,MEF2A,GSK3A,DUSP6,FOXC1
roce
ss
1.83
717
715
8
deoxyribonucleotide biosynthetic process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
3.36
815
812
3
neuroblast division
biol
ogic
al_p LEF1,FGFR1,RAB10
roce
ss
3.36
815
812
3
LTBP4,ENG,TGFBR3
3.37
669
071
2
3
8
E
0
2
5.
3
8
E
0
2
5.
4
0
E
0
2
5.
4
1
E
0
2
5.
4
1
E
-
7
G
O:
00
72
58
3
clathrin-mediated endocytosis
biol
ogic
al_p TNK2,AAK1,CANX
roce
ss
3.36
815
812
3
keratan sulfate catabolic process
biol
ogic
al_p HEXA,ACAN,FMOD
roce
ss
3.36
815
812
3
cerebral cortex radial glia guided migration
biol
ogic
al_p PAFAH1B1,SRGAP2,GLI3
roce
ss
3.36
815
812
3
G
O:
00
50
85
8
negative regulation of antigen receptormediated signaling pathway
biol
ogic
al_p PTPN22,PTPN6,PHPT1
roce
ss
3.36
815
812
3
G
O:
positive regulation of transcription
elongation from RNA polymerase II
biol
ogic
3.36
815
G
O:
00
42
34
0
G
O:
00
21
80
1
SUPT5H,PAF1,WDR61
0
2
5.
4
1
E
0
2
5.
4
1
E
0
2
5.
4
1
E
0
2
5.
4
1
E
0
2
5.
4
00
32
96
8
G
O:
00
72
04
4
G
O:
00
51
64
2
G
O:
00
45
06
0
G
O:
00
08
20
1
promoter
al_p
roce
ss
812
3
collecting duct development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
3.36
815
812
3
centrosome localization
biol
ogic
al_p PAFAH1B1,SEMA6A,SUN2
roce
ss
3.36
815
812
3
negative thymic T cell selection
biol
ogic
al_p MINK1,PTPRC,GLI3
roce
ss
3.36
815
812
3
heparin binding
mol
ecul
ar_f
unct
ion
1.57
055
382
ADAMTS1,HSD17B12,HDGF,AAMP,FGFR1,THBS3,PAFAH1B1,NRP1,P
TPRF,PTPRC,ABI3BP,LRPAP1,FGF14,COL13A1,TGFBR3
1
E
0
2
5.
4
1
E
0
2
5.
4
1
E
0
2
5.
4
1
E
0
2
5.
4
1
E
0
2
G
O:
00
05
53
9
glycosaminoglycan binding
mol
ecul
ar_f
unct
ion
ADAMTS1,HSD17B12,NOD1,HDGF,AAMP,FGFR1,THBS3,LTBP4,PAFA
H1B1,NRP1,PTPRF,PTPRC,ABI3BP,LRPAP1,ENG,FGF14,COL13A1,T
GFBR3,ACAN
1.48
340
17
cardiac chamber development
biol
ogic
NPHP3,CPE,TBX2,SMAD7,ADAMTS1,FKBP1A,ZFPM2,SMARCD3,MEF
al_p
2A,GAA,SMARCA4,GSK3A,TGFBR3,FOXC1
roce
ss
1.59
844
792
3
ligase activity, forming carbon-nitrogen
bonds
mol
ecul
ar_f
unct
ion
PSMB10,PPIL2,MARCH5,ZFP91,SMAD7,TTLL3,PSMB9,RNF220,MARC
H6,ANAPC4,PLK1,ASNS,RC3H1,HERC2,MIB2,NADSYN1,RNF8,MDM2,
UBE2Q1,RNF168,RNF217,CHFR,PTEN,TMEM189,PIAS2,MYCBP2,RNF
213,TRIM28,PSMC6,RNF146,PSMC4,CDC14B,WWP1,TTLL11,FBXW2,
FPGS,AMFR,PSMA1,ATG3,UBR5
1.29
561
274
3
G
O:
00
61
35
1
neural precursor cell proliferation
biol
ogic
FZD6,BDNF,LEF1,EMX2,FGFR1,NF1,PAFAH1B1,SMARCD3,RAB10,GL
al_p
I3,NCOR2,GATA2
roce
ss
1.66
671
742
2
G
O:
mitochondrion organization
biol
ogic
1.39
757
G
O:
00
03
20
5
G
O:
00
16
87
9
TAZ,MARCH5,BCL2L11,TTC19,DNM1L,SEPT4,CNP,CLN8,TIMM23,SH
ARPIN,PLD6,FLCN,MEF2A,SSBP1,COX14,TIMM50,GRPEL2,GOLPH3,
5.
4
2
E
0
2
5.
4
4
E
0
2
5.
4
8
E
0
2
5.
5
0
E
0
2
5.
5
00
07
00
5
G
O:
00
50
66
1
G
O:
00
17
13
7
G
O:
00
43
20
2
G
O:
00
90
34
2
al_p BCS1L,SLC25A6,POLG,TFAM,ATG3,LETM1,MTO1
roce
ss
598
5
NADP binding
mol
ecul
ar_f
unct
ion
Rab GTPase binding
mol
ecul
ar_f
unct
ion
lysosomal lumen
cell
ular
_co RNASET2,TXNDC5,TPP1,HEXA,LGMN,GUSB,PDGFRB,ACAN,FMOD
mpo
nent
1.82
521
666
6
regulation of cell aging
biol
ogic
al_p MARCH5,LMNA,PTEN,CDK6
roce
ss
2.69
452
649
9
H6PD,FDXR,FMO2,GMDS,IDH1,MTRR,GAPDH
2.01
164
553
1
GAS8,SYTL4,SYTL2,BICD1,RAB8A,SGSM3,ERC1
2.01
164
553
1
9
E
0
2
5.
6
1
E
0
2
5.
6
1
E
0
2
5.
6
2
E
0
2
5.
6
3
E
0
2
G
O:
00
22
41
5
PSMB10,F11R,CDK13,CBX5,SUPT5H,VAPB,NUP98,VRK2,LEF1,HLAC,SUPT4H1,PSMB9,BCL2L11,FDPS,RAD23A,STAT2,MDM2,TBP,CREB
1,DDX58,RPL27,IFITM3,RPL9,RB1,BICD1,USP7,CUL4A,RPL24,RPL37
A,FYN,SRPK1,FBXW7,KPNB1,LTBR,UBP1,SP110,KLC1,RPL4,THOC2,
SLC25A6,WWP1,ITGA5,NCBP2,TNFRSF14,SMARCA4,RPLP0,DYNC1I
2,TSG101,USF1,KPNA1,PABPN1
viral reproductive process
biol
ogic
al_p
roce
ss
metanephros development
biol
ogic
PAX8,NF1,NIPBL,PKD2,CTSH,SMAD4,GLI3,PDGFRB,ROBO2,PKD1,F
al_p
OXC1
roce
ss
1.70
343
629
2
neuromuscular process controlling balance
biol
ogic
al_p CLN8,GIGYF2,PAFAH1B1,TPP1,HEXA,GAA,NLGN2
roce
ss
2.00
656
228
6
G
O:
00
70
60
3
SWI/SNF-type complex
cell
ular
_co CSNK2A1,YY1,INO80,RB1,SMARCD3,APPL2,INO80E,SMARCA4
mpo
nent
1.89
740
037
6
G
O:
response to DNA damage stimulus
biol
ogic
1.23
264
G
O:
00
01
65
6
G
O:
00
50
88
5
USP10,PSMB10,BCL6,MMS19,PNKP,PSMB9,RAD23A,APITD1,USP47,
PLK1,UPF1,HERC2,POLM,BCLAF1,WAC,PMS1,SGK1,RNF8,MDM2,ZF
1.25
155
602
4
5.
6
4
E
0
2
5.
6
6
E
0
2
5.
6
7
E
0
2
5.
7
6
E
0
2
5.
8
00
06
97
4
G
O:
00
97
19
4
G
O:
00
44
27
5
G
O:
00
44
72
8
G
O:
00
46
03
4
al_p YVE26,YY1,INO80,NIPBL,ALKBH3,CASP2,USP3,TP53BP1,RNF168,MU
roce M1,USP7,CUL4A,FBXW7,SETD8,TRIM28,PSMC6,PSMC4,ZSWIM7,AC
ss
D,DGKZ,INO80E,ING4,CDC14B,MAPK12,ERCC1,PHF1,HINFP,RAD51B
,POLG,ATXN3,PSMA1,CSNK1E,NSMCE4A,SHPRH,SPRED1,UBR5,EY
A2,SMARCAD1
855
9
execution phase of apoptosis
biol
ogic
al_p
roce
ss
cellular carbohydrate catabolic process
biol
ogic
al_p GK5,NCOR1,PHKG2,ARNT,GAA,GSK3A,PGM2,PHKG1
roce
ss
1.89
089
578
9
DNA methylation or demethylation
biol
ogic
al_p EHMT1,ALKBH3,USP7,PLD6,PIWIL4,SMARCA4,BAZ2A,HEMK1
roce
ss
1.89
089
578
9
ATP metabolic process
biol
ogic
al_p
roce
ss
1.28
459
984
2
SART1,BCL2L11,DNAJC10,DNM1L,SEPT4,BCLAF1,SHARPIN,DPF2,P
PM1F,TNFRSF25,CASP2,LMNA,CUL4A,FYN,KPNB1,LTBR,MAPK8,TIM
M50,UNC5B,DIABLO,LMNB1,ACIN1,TNFRSF10B,RRP8,KPNA1,STK24,
FASTK
CRBN,DHX34,MYO1D,ATP2B1,ATP6V1D,ABCC1,DDX23,DNAJC10,DD
X39A,SKIV2L,DHX9,UPF1,CHD6,PMS1,NADK,INO80,DDX58,G3BP1,D
DX6,FLCN,CTNS,ATP11B,DDX41,RNF213,ABCA2,PSMC6,SKIV2L2,PS
MC4,GRPEL2,ATP5A1,AK5,ATP8B2,RAD51B,SMARCA4,DHX40,LONR
F3,MYO1E,CHD2,LONP2,ACIN1,DHX37
1.37
268
331
1
0
E
0
2
5.
8
1
E
0
2
5.
8
3
E
0
2
5.
8
3
E
0
2
5.
8
5
E
0
2
G
O:
00
90
28
7
G
O:
00
46
46
7
G
O:
00
43
54
9
G
O:
00
19
21
9
regulation of cellular response to growth
factor stimulus
biol
ogic
SMAD7,GLG1,NPTN,ZEB1,LTBP4,GRB10,FLCN,RUNX2,USP15,SMAD
al_p
4,TGFB1I1,ENG,ARNT,ITGA5,DUSP6,TGFBR3,PDPK1
roce
ss
1.50
680
758
2
membrane lipid biosynthetic process
biol
ogic
VAPB,GPAA1,SMPD4,PIGS,PIGG,CLN8,PIGN,ST6GALNAC5,ELOVL1,
al_p
PIGO,PPAP2A,ALG9
roce
ss
1.64
971
010
1
regulation of kinase activity
biol
ogic
al_p
roce
ss
regulation of nucleobase-containing
compound metabolic process
ACADVL,IGF1R,RAF1,ZFP91,VAPB,XBP1,ADAM8,PTPN6,NOD1,PRKA
CA,PLK1,ASNS,HDGF,CCNL1,FAM58A,STK4,FGFR1,ADCY4,TAB2,SE
C31A,PPM1F,CCNL2,NF1,PKD2,LMNA,RB1,MAPK8IP3,TPP1,SH3BP5,
RGS3,PTEN,IQGAP1,FBXW7,HERPUD1,PXN,PRKRIP1,CSK,PTPRC,P
AK1,NCK2,CSF1R,AK5,NOX4,PDIA5,MDFI,RGS2,PDGFRB,CARD14,YI
F1A,TLN1,GSK3A,IGF2,PDCD4,CRIPAK,CDK5RAP1,NTRK1,SPRED1,T
NFRSF10B,DUSP6,PKD1,PDPK1,CDK5RAP3,WNK1
FZD6,OBFC1,RAB3GAP2,PBX2,KANK2,ACADVL,RAI1,IGF1R,SIRT2,R
ALGAPA2,MYNN,NOC2L,RAF1,ZNF131,RSC1A1,SFSWAP,CDK13,SIN
biol 3B,CBX5,SUPT5H,SUPT20H,BCL6,FUBP1,ZNF783,TBX2,MMS19,VAP
ogic B,CUX1,EED,SMAD7,MCF2L,HDAC6,ARHGEF12,EHMT1,ZNF496,LAN
al_p CL2,LEF1,PAX8,SUPT4H1,ZNF83,EMX2,RBPMS,STARD13,ZSCAN31,
roce XBP1,PAM,SNRNP70,USP47,ADAM8,GABPB1,DNAJC10,PCGF6,RAN
ss
BP1,SIPA1L1,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,STAT2,PLK1,ZNF
446,ASNS,TBC1D2B,PTGES2,ZNF621,HDGF,CCNL1,CHD6,ZC3H12A,
TBC1D10B,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF39
1.21
775
587
8
1.07
864
032
3
5.
8
6
E
0
2
5.
8
7
E
0
2
5.
8
7
E
0
2
5.
8
9
E
0
2
G
O:
00
70
88
cellular response to chemical stimulus
7,JHDM1D,ZNF710,TBC1D14,GIT2,WAC,ZNF142,FUBP3,ZNF540,FGF
R1,HSF4,CELF1,PAF1,TAB2,SGK1,DPF2,RNF8,SEC31A,MDM2,PRKC
H,PPM1F,ZNF595,TBP,YY1,FAM13A,INO80,GMEB2,PFDN5,CREB1,FLI
I,RPRD1A,DDX58,CCNL2,PTPRK,SNX13,NF1,ZEB1,IFITM3,ASCC2,RG
MB,EBF1,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,R
XRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,RNF168,PAFAH
1B1,ZNF865,SENP2,TPP1,SUB1,CHMP1A,PDE8A,ACAP2,ZNF558,ZNF
263,ZNF180,BICD1,ZNF276,RGS3,NR1H3,USP7,FLCN,ZNF605,ZNF41
0,ARHGAP9,SAP30BP,VPS72,PTEN,SRPK1,RUNX2,IQGAP1,FBXW7,S
MARCD3,HERPUD1,IKBKB,RQCD1,SRGAP2,RFX7,NCOR1,MEF2A,SE
TD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF
4,TRIM28,DMTF1,CDK5RAP2,PTPRC,TBCD,UBP1,WDR61,EBF4,ZNF1
48,ZNF76,ARHGAP29,SGSM3,STAG2,SP110,NCK2,TCF4,ACD,IKZF5,
HMGN2,SEMA4D,SSBP2,ERC1,NFYC,SRSF10,SS18,RCOR3,SMAD4,
CHURC1,CHURC1FNTB,TBC1D22A,ZNF114,MIER2,TGFB1I1,INO80E,ZNF44,CREBZF,IN
G4,ZNF687,CLK3,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,TMED2,M
APK12,CCDC59,DCAF6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZN
F692,ERCC1,PHF1,STK36,WWP1,ARHGEF7,PHF12,PDIA5,ASAP1,ME
D6,MDFI,ZNF554,CIZ1,RGS2,HINFP,NCBP2,MLX,PDGFRB,TGS1,CDK
11A,GLIS3,ELP6,BDP1,RUNX1,SMARCA4,NAA16,LRPPRC,YIF1A,RAD
54L2,ZNF518B,CLK4,ZNF90,ZNF638,PER3,TLN1,GSK3A,ZNF383,NCO
R2,SETD2,IGF2,PTGIS,ATXN3,PHF21A,PDCD4,SOX13,CHD2,STAT6,S
ON,ZNF138,ZNF705A,BNIP2,NTRK1,TFAM,BRWD1,SMAD9,TGFBR3,Z
BTB16,BAZ2A,RRP8,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOX
C1,KPNA1,CDK5RAP3,RAPGEF6,PABPC1,UBR5,FASTK,EYA2,SMAR
CAD1,CC2D1A,GATA2
biol ACADVL,IGF1R,EPHX2,RAF1,F11R,COL2A1,HLAogic DPB1,CMPK2,CNTF,EEF2K,VAPB,NUP98,SMPD4,SMAD7,HDAC6,GLG
al_p 1,ATP6V1D,VRK2,DERL2,IL15RA,LANCL2,LEF1,PAX8,HLAroce C,ITGA9,XBP1,HLAss
DQA1,ADAM8,XAF1,PTPN6,PRKACA,STAT2,ASNS,COL16A1,HDGF,N
1.12
707
341
1
5.
8
9
E
-
7
G
O:
00
00
24
5
G
O:
00
09
31
1
G
O:
00
43
PC1,ZC3H12A,NUP210,SLC11A2,IL13RA1,CAMK2D,FGFR1,ADCY4,PD
E4D,PAF1,SHARPIN,CYP2R1,SEC31A,MDM2,RHBDD1,FKBP1A,PPM1
F,CREB1,NPTN,TNFRSF25,PTPRK,ZEB1,EIF4B,CRIP1,IFITM3,RPS6K
A5,RAB31,CAPN10,PKD2,RXRB,LMNA,LTBP4,PAFAH1B1,IL18,TPP1,C
HMP1A,AACS,NR1H3,GRB10,FLCN,NRP1,FMO2,PTEN,FYN,RUNX2,IQ
GAP1,PHPT1,HERPUD1,RQCD1,PXN,KPNB1,NCOR1,MEF2A,OXCT1,
LIFR,FIBP,USP15,DDX41,HLAF,DENND4C,CSK,PTPRC,RARRES2,NUP37,IL10RA,PAK1,LEPROT,LE
PR,RAB10,RHEB,CTSH,GNB3,CSF1R,ATP6V0A1,ALDH3B1,SMAD4,T
GFB1I1,DTYMK,NR2C2,IRF9,ENG,ARNT,NOX4,GAPDH,PDIA5,NUP85,
ITGA5,PDGFRB,EPOR,TNFRSF14,MKNK2,YIF1A,TLN1,FGF14,GSK3A,
NCOR2,IGF2,PTGIS,ATXN3,AMFR,STAT6,ROBO2,CLIC4,NTRK1,SMA
D9,HBB,DUSP6,TGFBR3,RRP8,PDPK1,USF1,KPNA1,SSH1,FMOD,ZC3
H15,PGRMC2
0
2
spliceosomal complex assembly
biol
ogic
al_p SFSWAP,DDX23,CELF1,SF3A2,SRSF10,SNRPE
roce
ss
2.12
725
776
2
oligosaccharide metabolic process
biol
ogic
al_p MPDU1,MAN1A2,ST6GALNAC5,GAA,MAN1B1,CTBS
roce
ss
2.12
725
776
2
regulation of mRNA stability
biol
ogic
DHX9,RC3H1,PAIP1,SERBP1,CIRBP,PABPC1
al_p
roce
2.12
725
776
2
5.
9
2
E
0
2
5.
9
2
E
0
2
5.
9
2
E
48
8
G
O:
00
33
55
8
G
O:
00
71
49
5
G
O:
00
17
14
5
G
O:
00
06
09
9
ss
protein deacetylase activity
mol
ecul
ar_f
unct
ion
cellular response to endogenous stimulus
IGF1R,RAF1,F11R,COL2A1,EEF2K,SMAD7,GLG1,ATP6V1D,LANCL2,L
EF1,PAX8,PTPN6,PRKACA,ASNS,COL16A1,NPC1,FGFR1,ADCY4,MD
biol
M2,FKBP1A,CREB1,NPTN,PTPRK,ZEB1,EIF4B,RAB31,CAPN10,RXRB,
ogic
LTBP4,IL18,AACS,NR1H3,GRB10,FLCN,PTEN,FYN,RUNX2,PXN,NCO
al_p
R1,FIBP,USP15,DENND4C,CSK,PAK1,LEPROT,RAB10,RHEB,CTSH,G
roce
NB3,ATP6V0A1,SMAD4,TGFB1I1,NR2C2,ENG,NOX4,PDGFRB,FGF14,
ss
GSK3A,NCOR2,IGF2,ROBO2,NTRK1,SMAD9,DUSP6,TGFBR3,PDPK1,
USF1,SSH1,FMOD,PGRMC2
stem cell division
biol
ogic
al_p LEF1,FGFR1,PAFAH1B1,RAB10,ZBTB16
roce
ss
2.32
286
767
1
tricarboxylic acid cycle
biol
ogic
al_p IDH3G,IDH1,DLST,SDHA,IDH3B
roce
ss
2.32
286
767
1
SIRT2,HDAC6,NCOR1,MAPK8,SIRT7
2.32
875
221
5
1.20
291
361
5
0
2
5.
9
3
E
0
2
5.
9
7
E
0
2
5.
9
8
E
0
2
5.
9
8
E
0
2
G
O:
00
48
27
8
G
O:
00
70
92
5
G
O:
00
42
62
3
G
O:
00
30
21
8
G
O:
00
32
vesicle docking
biol
ogic
al_p SYTL2,RAB8A,VPS45,SCFD1,VTI1B
roce
ss
2.32
286
767
1
organelle assembly
biol
ogic
RAB34,STARD9,ATG4B,TBC1D14,INO80,ATG12,NCOR1,ERAL1,CENP
al_p
T,FLNA,HAUS5,ATG3,SENP6
roce
ss
1.60
682
772
9
ATPase activity, coupled
mol
ecul
ar_f
unct
ion
CRBN,DHX34,MYO1D,ATP2B1,ATP6V1D,ABCC1,DDX23,DDX39A,SKI
V2L,DHX9,UPF1,CHD6,DDX58,G3BP1,DDX6,ATP11B,DDX41,ABCA2,S
KIV2L2,ATP5A1,ATP8B2,RAD51B,SMARCA4,DHX40,LONRF3,MYO1E,
CHD2,LONP2,DHX37
1.35
067
628
5
erythrocyte differentiation
biol
ogic
BCL6,SLC11A2,RB1,NCOR1,FECH,CDK6,ARNT,SMARCA4,ACIN1,TGF
al_p
BR3,GATA2
roce
ss
1.68
407
906
2
septin cytoskeleton
cell
ular
SEPT5,SEPT4,SEPT2
_co
mpo
3.22
922
948
6
5.
9
8
E
0
2
6.
0
1
E
0
2
6.
0
3
E
0
2
6.
0
6
E
0
2
6.
0
7
E
15
6
G
O:
00
31
10
5
G
O:
00
35
09
8
G
O:
00
07
17
9
G
O:
00
12
50
6
nent
septin complex
cell
ular
_co SEPT5,SEPT4,SEPT2
mpo
nent
3.22
922
948
6
ESC/E(Z) complex
cell
ular
_co EED,PHF1,PHF19
mpo
nent
3.22
922
948
6
transforming growth factor beta receptor
signaling pathway
biol
ogic F11R,SMAD7,GLG1,FKBP1A,PTPRK,ZEB1,LTBP4,FLCN,NCOR1,USP1
al_p 5,SMAD4,TGFB1I1,ENG,PDGFRB,NCOR2,SMAD9,TGFBR3,PDPK1,FM
roce OD
ss
1.46
274
295
6
vesicle membrane
cell
ular
_co
mpo
nent
1.30
953
602
2
CPE,RAB34,HLA-DPB1,IL15RA,SYTL4,HLA-C,PAM,HLADQA1,AP3S2,ADAM8,CD9,VAMP7,CAMK2D,TNK2,SEC31A,MDM2,MC
FD2,SNX21,RAB31,EPN2,SNX17,CLTCL1,HLAF,RAB8A,DENND4C,CLTB,NCK2,RAB10,ATP6V0A1,TMED3,TMED2,CL
IC4,SEC31B,ZDHHC8,CD63
0
2
6.
0
7
E
0
2
6.
0
7
E
0
2
6.
0
8
E
0
2
6.
1
4
E
0
2
G
O:
00
50
65
7
G
O:
00
50
65
8
G
O:
00
51
23
6
G
O:
00
09
88
9
nucleic acid transport
biol
ogic
NUP98,FMR1,DDX39A,UPF3A,UPF1,NUP210,FYTTD1,SENP2,NUP37,
al_p
SRSF10,THOC2,NUP85,NCBP2,LRPPRC,PABPN1
roce
ss
1.54
266
784
3
RNA transport
biol
ogic
NUP98,FMR1,DDX39A,UPF3A,UPF1,NUP210,FYTTD1,SENP2,NUP37,
al_p
SRSF10,THOC2,NUP85,NCBP2,LRPPRC,PABPN1
roce
ss
1.54
266
784
3
establishment of RNA localization
biol
ogic
NUP98,FMR1,DDX39A,UPF3A,UPF1,NUP210,FYTTD1,SENP2,NUP37,
al_p
SRSF10,THOC2,NUP85,NCBP2,LRPPRC,PABPN1
roce
ss
1.54
266
784
3
regulation of biosynthetic process
FZD6,OBFC1,PBX2,KANK2,ACADVL,EIF2B4,RAI1,IGF1R,TNRC6A,SIR
T2,MYNN,TRNAU1AP,NOC2L,RAF1,ZNF131,RSC1A1,SFSWAP,CDK13
,SIN3B,CBX5,SUPT5H,SUPT20H,BCL6,FUBP1,ZNF783,TBX2,MMS19,
biol CUX1,EED,FMR1,SMAD7,MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,LEF
ogic 1,PAX8,SUPT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PAM,UHMK1,
al_p USP47,ADAM8,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,UPF3
roce A,NOD1,STAT2,PLK1,ZNF446,PTGES2,UPF1,ZNF621,HDGF,CCNL1,C
ss
HD6,ZC3H12A,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZN
F397,JHDM1D,ZNF710,GIGYF2,WAC,ZNF142,FUBP3,ZNF540,FGFR1,
HSF4,PAIP1,CAPRIN1,CELF1,PAF1,TAB2,SGK1,DPF2,RNF8,MDM2,P
RKCH,PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,SRP9,F
1.07
968
831
8
6.
1
5
E
0
2
6.
1
5
E
0
2
6.
1
5
E
0
2
6.
1
9
E
0
2
LII,RPRD1A,DDX58,CCNL2,PTPRK,NF1,ZEB1,EIF4B,IFITM3,ASCC2,R
GMB,EBF1,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,
RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,RNF168,ZNF86
5,SENP2,IL18,PUM2,SUB1,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF180,
BICD1,ZNF276,NR1H3,GRB10,USP7,FLCN,ZNF605,ZNF410,SAP30BP,
MAST2,VPS72,PTEN,RUNX2,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,
NCOR1,MEF2A,FECH,SETD8,SMEK1,NECAB3,PIAS2,MAPK8,MYCBP
2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RA
P2,UBP1,WDR61,EBF4,ZNF148,ZNF76,STAG2,SP110,NCK2,TCF4,AC
D,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,C3,NFYC,PIWIL4,SRSF10,SS
18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,C1QTNF3,TGFB1I1,DDAH1,INO80E,ZNF44,CRE
BZF,ING4,CD276,ZNF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,M
APK12,CCDC59,DCAF6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,ZN
F692,GAPDH,PHF1,STK36,WWP1,PHF12,MED6,MDFI,CIRBP,ZNF554,
CIZ1,RGS2,HINFP,NCBP2,LPCAT1,MLX,PDGFRB,TGS1,CDK11A,GLIS
3,ELP6,BDP1,RUNX1,MKNK2,SMARCA4,NAA16,LRPPRC,RAD54L2,ZN
F518B,ZNF90,ZNF638,PER3,GSK3A,ZNF383,NCOR2,SETD2,IGF2,PTG
IS,ATXN3,PSTK,PHF21A,PDCD4,SOX13,CHD2,STAT6,ZNF138,ZNF70
5A,NTRK1,TFAM,BRWD1,SMAD9,HBB,TGFBR3,ZBTB16,BAZ2A,RRP8,
VARS,LARS,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,DDAH
2,CDK5RAP3,PABPC1,EYA2,SMARCAD1,CC2D1A,GATA2
G
O:
00
43
06
8
G
O:
00
positive regulation of programmed cell
death
biol
ogic
al_p
roce
ss
NLRP1,PPP1R13B,BCL6,HDAC6,CASP4,LEF1,BCL2L13,BCL2L11,MAR
K4,ADAM8,NOD1,SHISA5,SEPT4,BCLAF1,STK4,DPF2,TNFRSF25,DFN
A5,NF1,COL18A1,CAPN10,CASP2,IL18,MTCH1,FLCN,SAP30BP,PTEN,
ALDH1A3,MEF2A,PTPRC,ING4,NOX4,TEX261,ARHGEF7,DIABLO,PDI
A3,PTGIS,NTRK1,DUSP6,ZBTB16,STK24
1.27
865
262
1
nucleocytoplasmic transport
biol
ogic
al_p
BCL6,NUP98,RBPMS,UHMK1,DDX39A,KPNA6,UPF3A,PRKACA,NUTF
2,UPF1,FYTTD1,MDM2,DDX58,NF1,PKD2,LMNA,KPNB1,PPP1R10,SR
SF10,SMAD4,C1QTNF3,FLNA,GLI3,THOC2,MDFI,NCBP2,MLX,TGS1,S
1.31
252
007
6.
2
0
E
0
2
6.
2
5
06
91
3
G
O:
00
34
99
2
G
O:
00
60
07
7
G
O:
00
42
82
7
G
O:
00
00
12
7
roce DAD1,PDIA3,PKD1,KPNA1,UBR5,PABPN1
ss
1
microtubule organizing center attachment
site
cell
ular
_co SYNE1,SUN2
mpo
nent
4.66
444
259
1
inhibitory synapse
cell
ular
_co CEP112,NLGN2
mpo
nent
4.66
444
259
1
platelet dense granule
cell
ular
_co HPS4,CD63
mpo
nent
4.66
444
259
1
transcription factor TFIIIC complex
cell
ular
_co GTF3C2,GTF3C1
mpo
nent
4.66
444
259
1
E
0
2
6.
3
1
E
0
2
6.
3
1
E
0
2
6.
3
1
E
0
2
6.
3
1
E
0
2
G
O:
00
05
68
2
U5 snRNP
cell
ular
_co DDX23,PRPF8
mpo
nent
4.66
444
259
1
invadopodium
cell
ular
_co DPP4,FAP
mpo
nent
4.66
444
259
1
SUN-KASH complex
cell
ular
_co SYNE1,SUN2
mpo
nent
4.66
444
259
1
G
O:
00
50
82
1
protein stabilization
biol
ogic
al_p SMAD7,HPS4,CREB1,PTEN,FBXW7,AAK1,ZSWIM7,FLNA,GAPDH
roce
ss
1.78
314
253
6
G
O:
00
00
nuclear-transcribed mRNA catabolic
process, deadenylation-dependent decay
biol
ogic
XRN1,PAIP1,EIF4B,DDX6,PAN2,RQCD1,PARN,PABPC1
al_p
roce
1.85
829
413
7
G
O:
00
71
43
7
G
O:
00
34
99
3
6.
3
1
E
0
2
6.
3
1
E
0
2
6.
3
1
E
0
2
6.
3
2
E
0
2
6.
3
4
E
28
8
G
O:
00
31
22
8
G
O:
00
45
78
7
G
O:
00
45
86
0
G
O:
00
30
65
9
ss
intrinsic to Golgi membrane
cell
ular
_co ST3GAL1,CUX1,QSOX1,ST3GAL4,GALNT2,ST6GALNAC5,PCSK7
mpo
nent
1.95
906
588
8
positive regulation of cell cycle
biol
ogic
BCL2L11,PLK1,ASNS,FGFR1,MDM2,PKD2,RB1,PAFAH1B1,CUL4A,PT
al_p
EN,PDGFRB,IGF2,PKD1
roce
ss
1.59
222
020
4
positive regulation of protein kinase activity
biol
ogic
al_p
roce
ss
ACADVL,IGF1R,RAF1,ZFP91,VAPB,XBP1,ADAM8,NOD1,PRKACA,ASN
S,HDGF,STK4,FGFR1,ADCY4,TAB2,SEC31A,PKD2,LMNA,MAPK8IP3,T
PP1,IQGAP1,FBXW7,HERPUD1,PXN,CSK,PTPRC,PAK1,CSF1R,NOX4,
PDIA5,MDFI,PDGFRB,CARD14,YIF1A,TLN1,GSK3A,IGF2,NTRK1,TNFR
SF10B,PKD1,PDPK1
1.27
569
961
3
cytoplasmic vesicle membrane
cell
ular
_co
mpo
nent
CPE,RAB34,HLA-DPB1,IL15RA,SYTL4,HLA-C,PAM,HLADQA1,AP3S2,ADAM8,CD9,VAMP7,CAMK2D,TNK2,SEC31A,MDM2,MC
FD2,SNX21,RAB31,EPN2,SNX17,CLTCL1,HLAF,RAB8A,DENND4C,CLTB,RAB10,ATP6V0A1,TMED3,TMED2,CLIC4,S
EC31B,ZDHHC8,CD63
1.31
066
981
9
0
2
6.
3
5
E
0
2
6.
3
7
E
0
2
6.
3
7
E
0
2
6.
3
9
E
0
2
G
O:
00
45
01
7
G
O:
00
34
66
0
G
O:
00
60
82
8
G
O:
00
46
64
9
G
O:
00
35
glycerolipid biosynthetic process
biol
ogic TAZ,PLD1,GPAA1,PGS1,HSD17B12,PIGS,PIGG,PIGN,CHKB,GPAT2,G
al_p PCPD1,NR1H3,PLD6,MTMR14,PTEN,FBXW7,C3,ELOVL1,MBOAT2,LP
roce CAT1,PCYT1A,PIGO,ALG9,PLA2G16
ss
1.38
773
896
9
ncRNA metabolic process
biol
ogic
al_p
roce
ss
1.33
392
400
9
regulation of canonical Wnt receptor
signaling pathway
biol
ogic
FZD6,CDK14,NPHP3,LEF1,TBX18,STK4,PFDN5,G3BP1,RNF146,GLI3,
al_p
BICC1,GSK3A,ANKRD6,CSNK1E,UBR5
roce
ss
1.53
098
096
5
lymphocyte activation
biol
ogic
al_p
roce
ss
CADM1,PSMB10,BTN3A1,SART1,HLADPB1,DPP4,BCL6,PTPN22,IL15RA,LEF1,HLADQA1,ADAM8,MINK1,PTPN6,IGBP1,JAG2,RC3H1,POLM,RNF8,FKBP1
A,ZEB1,RNF168,IL18,FYN,RUNX2,NCOR1,MEF2A,CSK,PTPRC,SWAP
70,IMPDH1,CDK6,PAK1,NCK2,CD276,GLI3,ERCC1,LGALS8,TNFRSF1
4,KIF13B,IGF2,STAT6,NTRK1,CD151,PDPK1
1.25
781
838
6
aorta development
biol
ogic
TBX2,PKD2,MYLK,PDGFRB
al_p
roce
XRN1,TARS,CLNS1A,TYW1B,NARS,RPP14,RARS,DIS3L,NOL8,PRMT5
,NSA2,GARS,PLD6,INTS4,SKIV2L2,FARSA,PPA2,WDR4,PIWIL4,NCBP
2,TGS1,SNRPE,FTSJ3,PSTK,CARS2,CDK5RAP1,RRP8,VARS,LARS,M
TO1
2.56
621
571
3
6.
4
1
E
0
2
6.
4
8
E
0
2
6.
4
8
E
0
2
6.
5
3
E
0
2
6.
5
6
E
90
4
G
O:
00
33
14
6
G
O:
00
50
85
6
G
O:
00
30
11
1
G
O:
00
31
05
8
ss
regulation of intracellular estrogen receptor
signaling pathway
biol
ogic
al_p KANK2,RQCD1,PAK1,CRIPAK
roce
ss
2.56
621
571
3
regulation of T cell receptor signaling
pathway
biol
ogic
al_p PTPN22,PTPN6,RC3H1,PHPT1
roce
ss
2.56
621
571
3
regulation of Wnt receptor signaling
pathway
biol
ogic FZD6,CDK14,NPHP3,LEF1,CSNK2A1,TBX18,STK4,PFDN5,G3BP1,SEN
al_p P2,GRB10,RNF146,GLI3,BICC1,MDFI,GSK3A,ANKRD6,CSNK1E,TMEM
roce 237,UBR5
ss
1.43
325
877
6
positive regulation of histone modification
biol
ogic
al_p RPS6KA5,NIPBL,NCOR1,WDR61,PHF1,PHF19
roce
ss
2.07
271
269
1
0
2
6.
5
6
E
0
2
6.
5
6
E
0
2
6.
5
7
E
0
2
6.
5
8
E
0
2
G
O:
00
42
14
7
G
O:
00
38
03
2
G
O:
00
07
04
1
G
O:
00
43
06
7
retrograde transport, endosome to Golgi
biol
ogic
al_p VTI1A,STX16,GCC2,WASH4P,ERC1,VPS51
roce
ss
2.07
271
269
1
termination of G-protein coupled receptor
signaling pathway
biol
ogic
al_p ARHGEF12,SNX13,RGS3,RGS2,ADRBK2,SNX14
roce
ss
2.07
271
269
1
lysosomal transport
biol
ogic
al_p HGS,NPC1,VAMP7,GCC2,HGSNAT,SNX27
roce
ss
2.07
271
269
1
regulation of programmed cell death
KANK2,PSMB10,IGF1R,NOC2L,RAF1,NLRP1,PPP1R13B,BDNF,SART1
,COL2A1,BCL6,CNTF,SMAD7,HDAC6,CASP4,LEF1,PAX8,PSMB9,BCL
2L13,BCL2L11,MARK4,USP47,ADAM8,NOL3,DNAJC10,KRIT1,LHX4,C
biol SNK2A1,IGBP1,NOD1,PLK1,ASNS,JAG2,DNM1L,SHISA5,SEPT4,SLC1
ogic 1A2,CLN8,BCLAF1,STK4,FGFR1,SGK1,DPF2,MDM2,RHBDD1,PRKCH,
al_p PPM1F,TNFRSF25,DFNA5,NF1,COL18A1,CAPN10,CASP2,LMNA,MITF
roce ,TXNDC5,IL18,MTCH1,ANXA5,PLK2,FLCN,CUL4A,SAP30BP,PTEN,FY
ss
N,ALDH1A3,LGMN,HERPUD1,LTBR,MEF2A,MAPK8,PTPRC,PSMC6,P
SMC4,CTSH,SEMA4D,TIMM50,ING4,GLI3,NOX4,ERCC1,TEX261,NRB
P2,ARHGEF7,UNC5B,ITGA5,CARD14,DIABLO,PDIA3,PTGIS,PSMA1,S
ON,BNIP2,NTRK1,TNFRSF10B,DUSP6,ZBTB16,RRP8,PDPK1,FOXC1,
1.15
291
476
1
6.
5
8
E
0
2
6.
5
8
E
0
2
6.
5
8
E
0
2
6.
5
9
E
0
2
DDAH2,STK24,FASTK,BCL2L2-PABPN1,BCL2L2
G
O:
00
42
80
2
G
O:
00
70
74
2
G
O:
00
05
09
5
G
O:
00
51
64
0
CRBN,CADM1,IGF1R,PTS,EPHX2,TARS,RAF1,COL2A1,CCDC91,DPP4
,SHMT2,VAPB,EED,NOL3,NOD1,ASNS,DNM1L,PPP5C,PDXK,TBX18,S
TK4,TPCN2,FGFR1,HPS4,SHARPIN,RNF8,MDM2,DDX58,RGMB,COL1
8A1,ZNF3,PKD2,MZF1,PAFAH1B1,CALCOCO2,SYNE1,GCC2,PLD6,DA
AM1,FAP,FYN,ALDH1A3,IDH1,IKBKB,SRGAP2,LTBR,MEF2A,OXCT1,M
YCBP2,GOPC,PAK1,CSF1R,HSD17B4,ROBO3,SMAD4,GRPEL2,TBC1
D22A,C1QTNF3,FLNA,SUN2,C1S,SDCBP2,ENG,EXT1,MLX,EPOR,RU
NX1,SUMF2,KLHL7,PCYT1A,STAT6,ROBO2,KCTD17,NTRK1,ZBTB16,
USF1,TENM4
identical protein binding
mol
ecul
ar_f
unct
ion
C2H2 zinc finger domain binding
mol
ecul
ar_f
unct
ion
GTPase inhibitor activity
mol
ecul
ar_f
unct
ion
organelle localization
biol
ogic SEPT5,HDAC6,DYNC1I1,ACTR3,SEC31A,SNAP23,NUMA1,RB1,BLOC1
al_p S5,PAFAH1B1,MEF2A,CDK5RAP2,SEMA6A,SUN2,TMED2,CIZ1,LRPP
roce RC,SDAD1,CLASP1
ss
1.18
453
387
2
LEF1,SRRM2,GATA2
3.11
694
527
3
TNK2,RTKN,IQGAP1
3.11
694
527
3
1.44
621
478
7
6.
5
9
E
0
2
6.
6
2
E
0
2
6.
6
2
E
0
2
6.
6
6
E
0
2
G
O:
00
10
95
4
G
O:
00
10
59
1
G
O:
00
48
56
9
G
O:
00
72
16
4
G
O:
00
43
positive regulation of protein processing
biol
ogic
al_p ADAM8,RHBDD1,C3
roce
ss
3.10
906
903
7
regulation of lamellipodium assembly
biol
ogic
al_p ACTR3,SSH2,SSH1
roce
ss
3.10
906
903
7
post-embryonic organ development
biol
ogic
al_p BCL2L11,ERCC1,MYO1E
roce
ss
3.10
906
903
7
mesonephric tubule development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
3.10
906
903
7
negative T cell selection
biol
ogic
MINK1,PTPRC,GLI3
al_p
roce
3.10
906
903
7
6.
6
6
E
0
2
6.
6
6
E
0
2
6.
6
6
E
0
2
6.
6
6
E
0
2
6.
6
6
E
38
3
G
O:
00
00
09
0
G
O:
00
03
20
7
G
O:
00
02
08
7
G
O:
00
32
48
6
ss
mitotic anaphase
biol
ogic
al_p ANAPC4,PLK1,NUMA1
roce
ss
3.10
906
903
7
cardiac chamber formation
biol
ogic
al_p TBX2,SMARCD3,MEF2A
roce
ss
3.10
906
903
7
regulation of respiratory gaseous exchange
by neurological system process
biol
ogic
al_p GLS,PBX3,NLGN2
roce
ss
3.10
906
903
7
Rap protein signal transduction
biol
ogic
al_p SIPA1L1,PLK2,SGSM3
roce
ss
3.10
906
903
7
0
2
6.
6
6
E
0
2
6.
6
6
E
0
2
6.
6
6
E
0
2
6.
6
6
E
0
2
G
O:
00
14
91
1
G
O:
00
46
82
4
G
O:
00
04
66
1
G
O:
00
70
08
7
G
O:
00
30
positive regulation of smooth muscle cell
migration
biol
ogic
al_p NRP1,NOX4,PDGFRB
roce
ss
3.10
906
903
7
positive regulation of nucleocytoplasmic
transport
biol
ogic
RBPMS,PRKACA,MDM2,DDX58,SMAD4,FLNA,GLI3,NCBP2,KPNA1,UB
al_p
R5
roce
ss
1.70
539
651
8
protein geranylgeranyltransferase activity
mol
ecul
ar_f
unct
ion
RABGGTA,RABGGTB
4.50
225
428
3
chromo shadow domain binding
mol
ecul
ar_f
unct
ion
NIPBL,TRIM28
4.50
225
428
3
semaphorin receptor binding
mol
ecul
ar_f
unct
SEMA6A,SEMA4D
4.50
225
428
3
6.
6
6
E
0
2
6.
6
6
E
0
2
6.
7
3
E
0
2
6.
7
3
E
0
2
6.
7
3
E
21
5
G
O:
00
02
47
8
G
O:
00
05
58
1
G
O:
00
51
05
6
G
O:
00
02
82
9
ion
antigen processing and presentation of
exogenous peptide antigen
biol
ogic PSMB10,HLA-DPB1,DYNC1I1,HLA-C,PSMB9,HLA-DQA1,HLAal_p DMB,SEC31A,LGMN,ITGB5,HLAroce F,PSMC6,PSMC4,KLC1,CANX,PDIA3,DYNC1I2,PSMA1
ss
1.46
088
786
1
collagen
cell
ular
COL9A1,COL2A1,COL16A1,COL14A1,COL12A1,COL18A1,COL9A3,C1
_co
QTNF3,COL8A1,COL13A1,PLOD2
mpo
nent
1.65
512
479
regulation of small GTPase mediated signal
transduction
biol
ogic
al_p
roce
ss
negative regulation of type 2 immune
response
biol
ogic
al_p BCL6,STAT6
roce
ss
RALGAPA2,RAF1,BCL6,MCF2L,ARHGEF12,ARHGEF25,STARD13,SIP
A1L1,RHOF,TBC1D2B,RHOBTB1,TBC1D10B,TBC1D14,GIT2,PLEKHG4
,FAM13A,PLEKHG5,NF1,PAFAH1B1,ACAP2,CYTH2,FLCN,ARHGAP9,I
QGAP1,SRGAP2,FLOT1,ARHGAP29,SGSM3,SEMA4D,DGKZ,TBC1D22
A,RASGRF2,ARHGEF7,ASAP1,FARP1,RGL2,PSD3,BNIP2,NTRK1,RAP
GEF6
1.27
400
780
1
4.49
087
749
8
0
2
6.
7
3
E
0
2
6.
7
3
E
0
2
6.
7
4
E
0
2
6.
7
6
E
0
2
G
O:
00
71
10
7
response to parathyroid hormone stimulus
biol
ogic
al_p PRKACA,IL18
roce
ss
4.49
087
749
8
tRNA transcription from RNA polymerase III
promoter
biol
ogic
al_p GTF3C2,GTF3C1
roce
ss
4.49
087
749
8
regulation of isotype switching to IgE
isotypes
biol
ogic
al_p BCL6,STAT6
roce
ss
4.49
087
749
8
G
O:
00
61
43
9
kidney vasculature morphogenesis
biol
ogic
al_p PKD2,PDGFRB
roce
ss
4.49
087
749
8
G
O:
00
90
positive regulation of protein
homodimerization activity
biol
ogic
CRBN,MEF2A
al_p
roce
4.49
087
749
8
G
O:
00
42
79
7
G
O:
00
48
29
3
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
07
3
G
O:
00
10
61
4
ss
negative regulation of cardiac muscle
hypertrophy
biol
ogic
al_p RGS2,GSK3A
roce
ss
4.49
087
749
8
negative regulation of pathway-restricted
SMAD protein phosphorylation
biol
ogic
al_p SMAD7,ENG
roce
ss
4.49
087
749
8
G
O:
00
42
79
1
5S class rRNA transcription from RNA
polymerase III type 1 promoter
biol
ogic
al_p GTF3C2,GTF3C1
roce
ss
4.49
087
749
8
G
O:
00
43
16
2
ubiquitin-dependent protein catabolic
process via the multivesicular body sorting
pathway
biol
ogic
al_p HDAC6,TSG101
roce
ss
4.49
087
749
8
G
O:
00
60
39
4
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
G
O:
00
35
30
5
G
O:
00
32
04
9
G
O:
00
71
91
0
G
O:
00
06
01
1
G
O:
00
18
negative regulation of dephosphorylation
biol
ogic
al_p IGBP1,IQGAP1
roce
ss
4.49
087
749
8
cardiolipin biosynthetic process
biol
ogic
al_p TAZ,PGS1
roce
ss
4.49
087
749
8
determination of liver left/right asymmetry
biol
ogic
al_p NPHP3,PKD2
roce
ss
4.49
087
749
8
UDP-glucose metabolic process
biol
ogic
al_p GALT,GSK3A
roce
ss
4.49
087
749
8
protein geranylgeranylation
biol
ogic
RABGGTA,RABGGTB
al_p
roce
4.49
087
749
8
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
34
4
G
O:
00
18
02
6
G
O:
00
72
04
9
G
O:
00
07
09
7
G
O:
00
61
43
8
ss
peptidyl-lysine monomethylation
biol
ogic
al_p EHMT1,SETD8
roce
ss
4.49
087
749
8
comma-shaped body morphogenesis
biol
ogic
al_p PAX8,PDGFRB
roce
ss
4.49
087
749
8
nuclear migration
biol
ogic
al_p PAFAH1B1,SUN2
roce
ss
4.49
087
749
8
renal system vasculature morphogenesis
biol
ogic
al_p PKD2,PDGFRB
roce
ss
4.49
087
749
8
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
G
O:
00
43
03
1
G
O:
00
02
03
9
G
O:
00
18
41
0
G
O:
00
05
93
8
G
O:
00
08
negative regulation of macrophage
activation
biol
ogic
al_p ZC3H12A,NR1H3
roce
ss
4.49
087
749
8
p53 binding
mol
ecul
ar_f
unct
ion
1.92
953
755
C-terminal protein amino acid modification
biol
ogic
al_p GPAA1,PIGS,PIGG,PIGN,PIGO
roce
ss
2.24
543
874
9
cell cortex
cell
ular CRIP2,RAI14,SEPT5,LANCL2,CAPZB,SEPT4,TCHP,TPM4,MED28,PKD
_co 2,PAFAH1B1,PXN,RAB10,EZR,FLNA,ADD3,ARHGEF7,CTTN,SEPT2,C
mpo LASP1
nent
1.42
789
058
9
zinc ion binding
mol
ecul
ar_f
unct
1.11
375
106
USP10,EHMT1,MDM2,TP53BP1,USP7,SETD8,SMARCA4
RSPRY1,LPP,DHX34,CRIP2,RAI1,SIRT2,UTRN,MYNN,ZNF131,RBM6,
CPE,MARCH5,BCL6,ZNF783,ZFP91,HDAC6,EHMT1,ZNF496,SYTL4,S
UPT4H1,ZNF83,ADAMTS1,ZSCAN31,CPM,PAM,ADAM8,RNF220,XAF1,
PCGF6,MARCH6,PDLIM5,RNF24,LHX4,ZNF446,UPF1,ZNF621,RC3H1,
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
7
6
E
0
2
6.
8
1
E
0
2
6.
8
3
E
27
0
G
O:
00
06
39
9
G
O:
00
48
86
9
ion
PDXK,HERC2,MIB2,PCGF1,ZNF721,ZNF397,JHDM1D,ZNF710,DNPEP,
USP20,GIT2,ZNF142,ZNF540,MAN2C1,MMP16,SF3A2,TAB2,SHARPIN,
DPF2,RNF8,MDM2,KCMF1,ZCCHC14,ZNF595,YY1,DDX58,ZCCHC9,LI
MCH1,ZEB1,CRIP1,PHF15,UNKL,ZNF3,ZNF837,RXRB,GALT,ZZEF1,R
ABGGTA,USP3,MZF1,ZFPM2,RNF168,ZNF865,RNF217,CHMP1A,ACA
P2,ZNF558,ADAM15,USP33,ZNF263,ZNF180,ZNF276,NR1H3,ZNF605,
CHFR,ZNF410,PTGR2,PXN,ADAMTS18,KPNB1,PPP1R10,ZMYM5,PIA
S2,MYCBP2,DDX41,RNF213,ZNF565,ZFAND2B,TRIM28,RNF146,AGBL
5,ZNF148,ZNF76,SP110,ZSWIM7,IKZF5,ZNF609,CHURC1,CHURC1FNTB,ZNF114,TGFB1I1,LIMD2,ZNF44,ING4,ZNF687,NR2C2,CA5B,GLI
3,ZSCAN5A,ZNF692,PHF1,DEF8,PHF12,ASAP1,ZNF554,PTGR1,CIZ1,
HINFP,MAN2A2,DZIP1,GLIS3,DBF4,TRIM41,ZNF518B,ZNF90,ZNF638,
PHC3,DNAJC21,LONRF3,ZNF383,AMFR,PHF21A,ZNF138,ZNF705A,S
HPRH,LIMS2,ZBTB16,ZDHHC8,BAZ2A,SIRT3,PHF19,LMCD1,ZC3H14,
MMP25,UBR5,PHC2,ZC3H15,GATA2
tRNA metabolic process
biol
ogic
TARS,TYW1B,NARS,RPP14,RARS,GARS,FARSA,PPA2,WDR4,PSTK,C
al_p
ARS2,CDK5RAP1,VARS,LARS,MTO1
roce
ss
cellular developmental process
FZD6,EIF2B4,CADM1,PSMB10,CLMN,IGF1R,LAMB1,NPHP3,RAF1,F11
R,COL9A1,BDNF,SART1,COL2A1,BCL6,TBX2,PTPN22,SPATA20,CNTF
,CUX1,SMAD7,BMP8A,GLG1,ARHGEF12,IL15RA,CD72,TTLL3,LEF1,P
biol
AX8,EMX2,ITGA9,XBP1,UHMK1,ADAM8,CAPZB,PRPF40A,CD9,SIPA1L
ogic
1,MINK1,PDLIM5,PTPN6,ACTR3,LHX4,VASP,CSNK2A1,PRKACA,JAG2
al_p
,DNM1L,RC3H1,ZC3H12A,SEPT4,POLM,SLC11A2,AAMP,CNP,CLN8,T
roce
BX18,BBS1,GIGYF2,FLG,STK4,FGFR1,HPS4,HSF4,CAPRIN1,CELF1,P
ss
DE4D,PAF1,SHARPIN,RNF8,KIAA0586,RHBDD1,PRKCH,DAZAP1,YY1,
SSH2,CREB1,NPTN,ALDH6A1,DFNA5,NF1,ZEB1,NUMA1,RGMB,COL1
8A1,MED28,ZNF3,RPS6KA5,NIPBL,RXRB,LMNA,MITF,ITGA3,RB1,LTB
0
2
1.51
946
983
6.
8
3
E
0
2
1.09
013
789
7
6.
8
6
E
0
2
P4,MAPK8IP3,ZFPM2,BLOC1S5,PAFAH1B1,IL18,MTCH1,AACS,ARPC2
,SYNE1,ADAM15,USP33,NR1H3,HEXA,PLD6,FLCN,NRP1,MAST2,STX
2,VPS72,PTEN,FYN,SRPK1,RUNX2,IQGAP1,FBXW7,SMARCD3,IFT17
2,GGNBP2,SRGAP2,NCOR1,MEF2A,FECH,TCTN1,SSBP1,CACNB1,M
YCBP2,PBX3,RAB8A,AFF4,TRIM28,CSK,CDK5RAP2,COL9A3,PTPRC,
CDK6,RARRES2,WDR61,FLOT1,STAG2,GOPC,RANBP9,WDR35,PAK1
,NCK2,RAB10,SEMA6A,TCF4,SEMA4D,CSF1R,HSD17B4,PIWIL4,ROB
O3,SS18,SMAD4,C1QTNF3,NAV1,TGFB1I1,DTYMK,EZR,CD276,NR2C
2,FLNA,RAB5A,GLI3,MAPK12,ENG,TCF12,ARNT,NOX4,EXT1,ERCC1,
NRBP2,STK36,TBCE,ASAP1,MED6,UNC5B,MDFI,PTPRD,ITGA5,RGS2,
HINFP,PDGFRB,DZIP1,LGALS8,CC2D2A,FARP1,RUNX1,SMARCA4,KI
F13B,PTPN23,TLN1,GSK3A,NCOR2,SETD2,COL13A1,TROVE2,MYO1
E,GPHN,STAT6,TANC1,ACIN1,PSD3,ROBO2,CACNB3,PMP22,CLIC4,C
DK5RAP1,BNIP2,NTRK1,SPATA6,BRWD1,SMAD9,DUSP6,TGFBR3,TM
EM237,ZBTB16,SEPT2,PDPK1,TSG101,FOXC1,ACAN,STK24,SEMA4B
,SSH1,CDK5RAP3,C2CD3,EYA2,WNK1,CLASP1,TENM4,GATA2
G
O:
00
48
19
3
Golgi vesicle transport
biol
ogic CUX1,COG4,VAMP7,BBS1,SEC31A,SNAP23,RAB31,STX16,TXNDC5,G
al_p CC2,RAB8A,CSK,STX18,GOPC,RAB10,TMED2,SCFD1,VAMP4,LMF1,S
roce CAMP1
ss
1.42
567
539
6
G
O:
00
10
81
1
positive regulation of cell-substrate
adhesion
biol
ogic
al_p UTRN,HSD17B12,PPM1F,PLEKHA2,ARPC2,CDK6,ABI3BP,COL8A1
roce
ss
1.82
679
762
6
G
O:
small conjugating protein ligase activity
mol
ecul
1.30
093
PSMB10,PPIL2,MARCH5,ZFP91,SMAD7,PSMB9,RNF220,MARCH6,AN
APC4,PLK1,RC3H1,HERC2,MIB2,RNF8,MDM2,UBE2Q1,RNF168,RNF2
6.
8
6
E
0
2
6.
8
8
E
0
2
6.
8
00
19
78
7
G
O:
00
55
07
2
G
O:
00
00
08
2
G
O:
00
50
79
4
ar_f
unct
ion
17,CHFR,PTEN,PIAS2,MYCBP2,RNF213,TRIM28,PSMC6,RNF146,PSM
C4,CDC14B,WWP1,FBXW2,AMFR,PSMA1,ATG3,UBR5
466
5
iron ion homeostasis
biol
ogic
SLC25A37,ATP6V1D,SLC11A2,TTC7A,FECH,CP,ATP6V0A1,MCOLN1,
al_p
NUBP1,MFI2,SFXN3
roce
ss
1.64
665
508
3
G1/S transition of mitotic cell cycle
biol
ogic KANK2,PSMB10,PSMB9,PTPN6,CAMK2D,MDM2,INO80,PKD2,CASP2,
al_p RB1,SLFN11,PLK2,CUL4A,PTEN,PSMC6,CDK6,PSMC4,DGKZ,HINFP,
roce DBF4,PSMA1,PKD1
ss
1.39
810
337
2
regulation of cellular process
FZD6,CDK14,USP10,CRBN,OBFC1,RAB3GAP2,PBX2,KANK2,CRIP2,A
CADVL,EIF2B4,CADM1,RAI1,PSMB10,CLMN,IGF1R,LAMB1,NPHP3,TN
RC6A,MYO1D,SIRT2,UTRN,RALGAPA2,MYNN,TRNAU1AP,BTN3A1,N
OC2L,RAF1,NLRP1,ZNF131,SEPT5,GP1BB,F11R,LEPRE1,PPP1R13B,
biol GAS8,RSC1A1,SFSWAP,CDK13,BDNF,SIN3B,CPE,CBX5,PLCD1,SART
ogic 1,COL2A1,RAB34,SUPT5H,SUPT20H,RILPL1,HLAal_p DPB1,MARCH5,UBXN1,DPP4,BCL6,FUBP1,ZNF783,TBX2,PTPN22,MM
roce S19,SHMT2,ZFP91,CNTF,EEF2K,PLD1,VAPB,CUX1,NUP98,EED,FMR1
ss
,SMAD7,MCF2L,USP4,HDAC6,GLG1,ARHGEF12,EHMT1,ATP6V1D,VR
K2,ZNF496,HGS,CASP4,DERL2,IL15RA,LANCL2,CD72,SYTL4,DGKA,A
RPC4-TTLL3,LEF1,PAX8,HLAC,SUPT4H1,ZNF83,PSMB9,EMX2,ITGA9,ARHGEF25,ADAMTS1,RGL4,
BCL2L13,BCL2L11,RBPMS,STARD13,ZSCAN31,XBP1,NISCH,PAM,SN
1.03
741
722
9
E
0
2
6.
9
0
E
0
2
6.
9
2
E
0
2
6.
9
4
E
0
2
RNP70,HSD17B12,HLADQA1,RAD23A,APITD1,MARK4,UHMK1,USP47,ADAM8,NOL3,CAPZB,
GABPB1,PRPF40A,DNAJC10,RAB35,XAF1,CD9,PCGF6,RANBP1,SIPA
1L1,KRIT1,MINK1,PDLIM5,RHOF,PTPN6,EEF1A1,ACTR3,LHX4,VASP,
CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC4,PLK1,APLN
R,ZNF446,PDE7B,ASNS,TBC1D2B,COL16A1,JAG2,DNM1L,TXNL1,PT
GES2,UPF1,ZNF621,HDGF,RC3H1,PPP5C,NPC1,SHISA5,CCNL1,RHO
BTB1,CHD6,ZC3H12A,NUP210,TBC1D10B,SEPT4,MIB2,SLC11A2,SYM
PK,AAMP,FAM58A,RAB24,ATG4B,IL13RA1,CLN8,TBX18,LBX2,PCGF1,
VAMP7,DR1,BCLAF1,CAMK2D,ZNF721,ZNF397,JHDM1D,ZNF710,PLC
B4,JAM2,GIGYF2,TBC1D14,TNK2,USP20,GIT2,WAC,STK4,ZNF142,FU
BP3,TRO,ZNF540,TPCN2,FGFR1,RAB18,HSF4,DISP1,PAIP1,CAPRIN1
,ADCY4,CELF1,SNCAIP,PDE4D,PAF1,TAB2,SGK1,PLEKHG4,SHARPI
N,DPF2,TCHP,CPT1B,RNF8,KIAA0586,SEC31A,MDM2,RHBDD1,FKBP
1A,PRKCH,PPM1F,ZNF595,TBP,YY1,FAM13A,INO80,GMEB2,SSH2,PF
DN5,CREB1,NPTN,SRP9,RALGPS2,FLII,TNFRSF25,PLEKHG5,QSOX1,
RPRD1A,CCNDBP1,DDX58,ZCCHC9,LCP2,CCNL2,PTPRK,SNX13,DFN
A5,RHBDF1,MAGI1,NF1,ZEB1,EIF4B,NUB1,IFITM3,LGALS3BP,ASCC2,
SPSB3,RGMB,COL18A1,RTKN,EBF1,MED28,NPR1,ZNF3,RPS6KA5,G3
BP1,NIPBL,RAB31,BRD9,CAPN10,ZNF837,PKD2,CASP2,RXRB,LMNA,
MITF,NOL8,ITGA3,RB1,PRMT5,LTBP4,MAPK8IP3,GNAI1,PLEKHA2,MZ
F1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,RNF168,PAFAH1B1,ZN
F865,SENP2,IL18,PUM2,MTCH1,SLFN11,TPP1,SYTL2,SUB1,PWP2,CH
MP1A,PDE8A,AACS,ARPC2,STK38L,EPN2,ACAP2,ZNF558,ANXA5,SH
3BP5,USP33,ZNF263,ZNF180,BICD1,ZNF276,RGS3,GCC2,NR1H3,CYT
H2,GRB10,PLK2,USP7,FLCN,NRP1,CUL4A,ZNF605,CHFR,ZNF410,TX
NDC15,TENC1,GMDS,IGFBP6,ARHGAP9,SAP30BP,MAST2,STX2,FAP,
VPS72,PTEN,FYN,ALDH1A3,SRPK1,RUNX2,IQGAP1,FBXW7,PHPT1,L
GMN,SMARCD3,HERPUD1,IFT172,IKBKB,RQCD1,SNX17,PXN,ADAMT
S18,KPNB1,SRGAP2,RFX7,LTBR,PTPRF,NCOR1,MEF2A,OXCT1,TNS
1,FECH,LIFR,PRKRIP1,SETD8,SMEK1,WASH4P,ITGB5,TCTN1,NECAB
3,PIAS2,FIBP,CACNB1,VILL,MAPK8,SH3BP2,MYCBP2,CLTCL1,MYLK,
G
O:
00
07
16
9
G
O:
00
22
41
2
G
O:
00
51
transmembrane receptor protein tyrosine
kinase signaling pathway
USP15,DDX41,PBX3,HLAF,N6AMT1,ZNF565,ABCA2,RAB8A,AFF4,TRIM28,DMTF1,MAP4K4,CSK
,CDK5RAP2,PTPRS,PTPRC,OAZ1,PSMC6,TBCD,RNF146,UBP1,CDK6,
ABI3BP,RARRES2,WDR61,EBF4,NUP37,APPL2,ZNF148,ZNF76,FLOT1
,PSMC4,ARHGAP29,SGSM3,STAG2,AAK1,SP110,GOPC,IL10RA,PHK
G2,PAK1,EVC,NCK2,LEPROT,LEPR,RAB10,RHEB,SEMA6A,CTSH,TCF
4,ACD,IKZF5,HMGN2,SEMA4D,GNB3,SSBP2,CSF1R,ATP6V0A1,ERC1
,TIMM50,DGKZ,SEPW1,ACTR2,C3,NFYC,P4HB,PIWIL4,SRSF10,SS18,
RCOR3,SMAD4,FNTB,CHURC1,CHURC1FNTB,TBC1D22A,MEMO1,ZNF114,MIER2,C1QTNF3,TGFB1I1,DDAH1,I
NO80E,EZR,ASB8,ZNF44,CREBZF,GOLPH3,TANK,ING4,CD276,ZNF68
7,CDC14B,CLK3,NR2C2,FHOD1,DNTTIP2,LRPAP1,APOL3,FLNA,RAB5
A,IRF9,SUN2,ATP5A1,GLI3,TMED2,SDCBP2,MAPK12,CCDC59,DCAF6
,RASGRF2
IGF1R,RAF1,EEF2K,MCF2L,ARHGEF12,ATP6V1D,HGS,BCL2L11,SIPA
biol 1L1,PTPN6,PRKACA,GIGYF2,FGFR1,ADCY4,MDM2,CREB1,NPTN,PLE
ogic KHG5,LCP2,RHBDF1,EIF4B,RPS6KA5,CASP2,GRB10,NRP1,PTEN,RU
al_p NX2,FBXW7,IKBKB,PXN,MEF2A,FIBP,MAPK8,CSK,NCK2,LEPROT,RH
roce EB,CSF1R,ATP6V0A1,SS18,MAPK12,RASGRF2,EPS15L1,EPN1,ARNT
ss
,ARHGEF7,ITGA5,STAM2,PDGFRB,FGF14,GSK3A,IGF2,MYO1E,NTRK
1,MPZL1,DUSP6,PDPK1,FOXC1
1.21
526
078
5
cellular process involved in reproduction in
multicellular organism
biol
ogic CD9,PRKACA,SEPT4,CELF1,RNF8,RHBDD1,PAFAH1B1,PLD6,MAST2,
al_p SRPK1,AFF4,GOPC,ERCC1,DZIP1,RUNX1,PPAP2A,ROBO2,ZBTB16,F
roce OXC1
ss
1.43
808
998
5
localization
biol
ogic
al_p
roce
1.06
626
431
2
SLC25A37,CRBN,RAB3GAP2,CADM1,IGF1R,AVL9,LAMB1,SLC22A23,
UTRN,RALGAPA2,BTN3A1,NOC2L,PPIL2,RAF1,NLRP1,SEPT5,F11R,S
LC16A3,GAS8,RSC1A1,BDNF,ATP2B1,CPE,CCDC91,RAB34,SLC38A9,
MARCH5,DPP4,BCL6,GPAA1,CUX1,CLNS1A,NUP98,SLC9B2,FMR1,S
6.
9
5
E
0
2
6.
9
6
E
0
2
7.
0
3
E
17
9
ss
MAD7,USP4,HDAC6,ATP6V1D,DYNC1I1,HGS,DERL2,SYTL4,LEF1,GL
S,PAX8,EMX2,ITGA9,RBPMS,XBP1,COG4,NISCH,PAM,ABCC1,AP3S2,
MPDU1,UHMK1,ADAM8,PRPF40A,RAB35,CD9,RANBP1,DDX39A,KRIT
1,KPNA6,MINK1,PTPN6,ACTR3,IGBP1,UPF3A,PRKACA,PLK1,VPS52,L
MAN2,NUTF2,JAG2,DNM1L,PTGES2,UPF1,NPC1,HERC2,ZC3H12A,N
UP210,SLC11A2,AAMP,RAB24,ATG4B,SLC26A6,CNP,CLN8,VAMP7,C
AMK2D,FYTTD1,SLC16A1,BBS1,JAM2,TNK2,USP20,STK11IP,SLC38A
2,TPCN2,VTI1A,FGFR1,HPS4,RAB18,DISP1,ADCY4,SNCAIP,PDE4D,S
LC4A2,TIMM23,SGK1,SLC9A5,CPT1B,SEC31A,MDM2,RHBDD1,SNAP
23,SFT2D2,FKBP1A,PPM1F,YY1,TLN2,MCFD2,CREB1,SRP9,SLC35F5
,PLEKHG5,DDX58,RPL27,LCP2,PTPRK,SNX13,AP4B1,RHBDF1,SNX21
,NF1,REPS1,LGALS3BP,NUMA1,COL18A1,RPL9,NPR1,G3BP1,NIPBL,
RAB31,CAPN10,PKD2,SLC12A6,LMNA,RSL1D1,ITGA3,RB1,LTBP4,MA
PK8IP3,GNAI1,STX16,BLOC1S5,TXNDC5,NEXN,PAFAH1B1,MFSD10,S
ENP2,MTCH1,ESAM,STARD3,SYTL2,CHMP1A,AACS,SYNE1,EPN2,US
P33,BICD1,GCC2,NR1H3,CYTH2,GRB10,HEXA,FLCN,NRP1,RPL24,RP
L37A,STX2,FAP,PTEN,FYN,IQGAP1,FBXW7,CEP112,PHPT1,IKBKB,CT
NS,SNX17,KPNB1,SRGAP2,NCOR1,ATP11B,PPP1R10,MEF2A,OXCT1,
TNS1,COX7A2L,WASH4P,NECAB3,CACNB1,MAPK8,MYCBP2,CLTCL1
,MYLK,OSBPL3,ABCA2,RAB8A,SLC35D2,DENND4C,CSK,CDK5RAP2,
CP,PTPRC,TMEM66,STX18,CDK6,RARRES2,NUP37,SLC12A8,CLTB,M
FSD12,FLOT1,MFSD1,AAK1,GOPC,PAK1,NCK2,LEPROT,RAB10,SEM
A6A,PEAR1,CTSH,VPS45,ACD,TRPM7,SEMA4D,CSF1R,ATP6V0A1,E
RC1,TIMM50,OS9,DGKZ,C3,SRSF10,TMED3,ROBO3,SMAD4,GRPEL2,
C1QTNF3,NAV1,SLC35A4,SLC39A7,SLC4A4,EZR,RPL4,SLC23A2,LRP
AP1,APOL3,FLNA,RAB5A,CA5B,SUN2,HGSNAT,ATP5A1,GLI3,TMED2,
SDCBP2,EPS15L1,EPN1,THOC2,MCOLN1,ENG,SCFD1,NOX4,VTI1B,G
AA,SLC25A6,ATP8B2,VAMP4,TRAPPC12,MDFI,NUP85,SLCO2B1,CIZ1
,ITGA5,HINFP,STAM2,NCBP2,MLX,PDGFRB,VPS51,TGS1,ELP6,RAP1
B,CANX,RUNX1,MFI2,LRPPRC,YIF1A,RPLP0,DHX40,SDAD1,SNX27,KI
F13B,RHBDF2,CRCP,TLN1,FGF14,ADRBK2,GSK3A,NLGN2,NCOR2,S
ETD2,TWF1,SFXN3,ATG4A,PPAP2A,PDIA3,MYO1E,ATG16L2,DYNC1I
0
2
2,SLC38A5,SNX14,LONP2,PSD3,CSNK1E,SLC25A24,CACNB3,CLIC4,
CACNA2D1,ATG3,HBB,LMF1,TGFBR3,SEC31B,CACNA2D4,SLC25A46
,CD151,SPCS3,SEPT2,UQCRH,PKD1,PDPK1,TSG101,LRP3,FOXC1,K
PNA1,SLC9A8,STK24,CD63,SCAMP1,UBR5,WNK1,CLASP1,GATA2,G
ORASP1,PABPN1
G
O:
00
90
06
8
G
O:
00
07
01
8
G
O:
00
00
77
7
G
O:
00
07
26
5
positive regulation of cell cycle process
biol
ogic
PSMB10,LEF1,PSMB9,RANBP1,PRKACA,PLK1,MDM2,PKD2,CASP2,R
al_p
B1,CUL4A,PTEN,PSMC6,PSMC4,PDGFRB,IGF2,PSMA1,RRP8
roce
ss
1.45
214
002
9
microtubule-based movement
biol
ogic NPHP3,HDAC6,DYNC1I1,STARD9,AP3S2,IGBP1,BLOC1S5,PAFAH1B1
al_p ,BICD1,KIFC2,KLC1,DNHD1,ACTR10,STK36,LRPPRC,KIF13B,DYNC1I
roce 2
ss
1.46
817
149
condensed chromosome kinetochore
cell
ular
DYNC1I1,APITD1,PLK1,TP53BP1,DSN1,NUP37,CENPT,NUP85,SEPT2,
_co
CLASP1
mpo
nent
1.68
594
310
5
Ras protein signal transduction
biol
ogic
al_p
roce
ss
1.26
402
272
8
RALGAPA2,RAF1,BCL6,PLD1,MCF2L,ARHGEF12,ARHGEF25,NISCH,S
IPA1L1,TBC1D2B,TBC1D10B,TBC1D14,GIT2,PLEKHG4,PLEKHG5,NF1
,RTKN,G3BP1,RB1,PAFAH1B1,ACAP2,CYTH2,PLK2,FLCN,IQGAP1,SR
GAP2,FLOT1,ARHGAP29,SGSM3,SEMA4D,DGKZ,TBC1D22A,MAPK12
,RASGRF2,ARHGEF7,ASAP1,FARP1,RGL2,PSD3,NTRK1,RAPGEF6
7.
0
4
E
0
2
7.
1
1
E
0
2
7.
1
2
E
0
2
7.
1
3
E
0
2
G
O:
00
34
34
1
response to interferon-gamma
biol
ogic HLA-DPB1,HLA-C,HLAal_p DQA1,PTPN6,CAMK2D,NUB1,IFITM3,IL18,CALCOCO2,NR1H3,HLAroce F,IRF9,GAPDH
ss
1.56
378
77
astral microtubule
cell
ular
_co PAFAH1B1
mpo
nent
13.9
933
277
7
collagen type VIII
cell
ular
_co COL8A1
mpo
nent
13.9
933
277
7
G
O:
00
30
93
6
transmembrane collagen
cell
ular
_co COL13A1
mpo
nent
13.9
933
277
7
G
O:
collagen type XII
cell
ular
13.9
933
G
O:
00
00
23
5
G
O:
00
05
59
1
COL12A1
7.
1
4
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
00
05
59
5
G
O:
00
05
60
0
G
O:
00
00
83
5
G
O:
00
72
51
7
G
O:
00
43
25
7
_co
mpo
nent
277
7
collagen type XIII
cell
ular
_co COL13A1
mpo
nent
13.9
933
277
7
ER ubiquitin ligase complex
cell
ular
_co OS9
mpo
nent
13.9
933
277
7
host cell viral assembly compartment
cell
ular
_co BICD1
mpo
nent
13.9
933
277
7
laminin-8 complex
cell
ular
_co LAMB1
mpo
nent
13.9
933
277
7
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
G
O:
00
05
89
8
interleukin-13 receptor complex
cell
ular
_co IL13RA1
mpo
nent
13.9
933
277
7
micro-ribonucleoprotein complex
cell
ular
_co TNRC6A
mpo
nent
13.9
933
277
7
collagen type XVI
cell
ular
_co COL16A1
mpo
nent
13.9
933
277
7
G
O:
00
71
13
3
alpha9-beta1 integrin-ADAM8 complex
cell
ular
_co ADAM8
mpo
nent
13.9
933
277
7
G
O:
aster
cell
ular
13.9
933
G
O:
00
35
06
8
G
O:
00
05
59
7
PAFAH1B1
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
00
05
81
8
G
O:
00
70
82
6
G
O:
00
05
73
1
G
O:
00
05
59
6
G
O:
00
05
60
7
_co
mpo
nent
277
7
paraferritin complex
cell
ular
_co SLC11A2
mpo
nent
13.9
933
277
7
nucleolus organizer region
cell
ular
_co SIRT7
mpo
nent
13.9
933
277
7
collagen type XIV
cell
ular
_co COL14A1
mpo
nent
13.9
933
277
7
laminin-2 complex
cell
ular
_co LAMB1
mpo
nent
13.9
933
277
7
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
G
O:
00
00
83
6
Hrd1p ubiquitin ligase complex
cell
ular
_co OS9
mpo
nent
13.9
933
277
7
short-chain collagen
cell
ular
_co COL8A1
mpo
nent
13.9
933
277
7
nuclear condensin complex
cell
ular
_co NCAPD3
mpo
nent
13.9
933
277
7
G
O:
00
31
59
2
centrosomal corona
cell
ular
_co CLASP1
mpo
nent
13.9
933
277
7
G
O:
DNA polymerase III complex
cell
ular
13.9
933
G
O:
00
05
59
8
G
O:
00
00
79
9
CRCP
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
00
09
36
0
G
O:
00
05
58
5
G
O:
00
97
14
1
G
O:
00
97
14
0
G
O:
00
30
87
4
_co
mpo
nent
277
7
collagen type II
cell
ular
_co COL2A1
mpo
nent
13.9
933
277
7
BIM-BCL-2 complex
cell
ular
_co BCL2L11
mpo
nent
13.9
933
277
7
BIM-BCL-xl complex
cell
ular
_co BCL2L11
mpo
nent
13.9
933
277
7
nucleolar chromatin
cell
ular
_co SIRT7
mpo
nent
13.9
933
277
7
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
7.
1
5
E
0
2
G
O:
00
32
12
7
dense core granule membrane
cell
ular
_co ADAM8
mpo
nent
13.9
933
277
7
single-organism carbohydrate catabolic
process
biol
ogic
GK5,H6PD,GALT,NCOR1,PHKG2,FUT4,ARNT,GAPDH,GAA,ENO4,GSK
al_p
3A,PGM2,CTBS,PHKG1,RBKS
roce
ss
1.50
813
050
3
oxidoreductase activity, acting on the
aldehyde or oxo group of donors
mol
ecul
ar_f
unct
ion
2.02
601
442
7
G
O:
00
43
95
4
cellular component maintenance
biol
ogic
al_p NPHP3,CLN8,BBS1,CSF1R,NLGN2,TANC1
roce
ss
2.02
089
487
4
G
O:
positive regulation of cell death
biol
ogic
1.25
744
G
O:
00
44
72
4
G
O:
00
16
90
3
ALDH18A1,ALDH6A1,ALDH1A3,ALDH16A1,ALDH3B1,GAPDH
NLRP1,PPP1R13B,BCL6,HDAC6,CASP4,LEF1,BCL2L13,BCL2L11,MAR
K4,ADAM8,NOD1,SHISA5,SEPT4,BCLAF1,STK4,DPF2,TNFRSF25,DFN
7.
1
5
E
0
2
7.
1
9
E
0
2
7.
2
1
E
0
2
7.
2
8
E
0
2
7.
3
00
10
94
2
G
O:
00
97
34
6
G
O:
00
31
01
1
G
O:
00
31
25
8
G
O:
00
33
20
2
al_p A5,NF1,COL18A1,CAPN10,CASP2,IL18,MTCH1,FLCN,SAP30BP,PTEN,
roce ALDH1A3,MEF2A,PTPRC,ING4,NOX4,TEX261,ARHGEF7,DIABLO,PDI
ss
A3,PTGIS,NTRK1,HBB,DUSP6,ZBTB16,STK24
569
9
INO80-type complex
cell
ular
_co YY1,INO80,INO80E
mpo
nent
2.99
857
023
7
Ino80 complex
cell
ular
_co YY1,INO80,INO80E
mpo
nent
2.99
857
023
7
lamellipodium membrane
cell
ular
_co DPP4,VASP,FAP
mpo
nent
2.99
857
023
7
DNA helicase complex
cell
ular
_co YY1,INO80,INO80E
mpo
nent
2.99
857
023
7
1
E
0
2
7.
3
3
E
0
2
7.
3
3
E
0
2
7.
3
3
E
0
2
7.
3
3
E
0
2
G
O:
00
06
45
7
protein folding
biol
ogic PPIL2,MPDU1,CSNK2A1,FKBP1A,PFDN5,TTC1,QSOX1,FKBP10,LTBP
al_p 4,EDEM2,TBCD,NFYC,P4HB,GRPEL2,LRPAP1,PDIA5,TBCE,MAN1B1,
roce CANX,DNAJC21,PDIA3
ss
1.40
062
021
liver development
biol
ogic
CADM1,NPHP3,ASNS,NF1,PKD2,AACS,FBXW7,RUNX1,SMARCA4,FP
al_p
GS,TGFBR3
roce
ss
1.62
855
997
2
antigen processing and presentation of
exogenous antigen
biol
ogic PSMB10,HLA-DPB1,DYNC1I1,HLA-C,PSMB9,HLA-DQA1,HLAal_p DMB,SEC31A,LGMN,ITGB5,HLAroce F,PSMC6,PSMC4,KLC1,CANX,PDIA3,DYNC1I2,PSMA1
ss
1.44
349
633
9
G
O:
00
06
32
5
chromatin organization
biol
ogic
al_p
roce
ss
SIRT2,NOC2L,SUPT5H,EED,HDAC6,EHMT1,LEF1,SUPT4H1,CHD6,PC
GF1,DR1,JHDM1D,WAC,HSF4,PAF1,RNF8,INO80,PHF15,RPS6KA5,NI
PBL,BRD9,RB1,PRMT5,USP3,RNF168,MUM1,FLCN,VPS72,SRPK1,SM
ARCD3,NCOR1,SETD8,MAPK8,WDR61,HMGN2,ING4,MSL1,SIRT7,PH
F1,SMARCA4,SETD2,KANSL3,ATXN3,PHF21A,SHPRH,BAZ2A,RRP8,P
HF19,UBR5,EYA2,SMARCAD1,GATA2
1.22
478
477
2
G
O:
regulation of biological quality
biol
ogic
FZD6,SLC25A37,OBFC1,ACADVL,EIF2B4,CKB,IGF1R,EPHX2,PPIL2,R
AF1,SEPT5,GP1BB,F11R,SLC16A3,COL9A1,BDNF,ATP2B1,CPE,CBX5
1.09
432
G
O:
00
01
88
9
G
O:
00
19
88
4
7.
3
4
E
0
2
7.
3
5
E
0
2
7.
3
7
E
0
2
7.
3
8
E
0
2
7.
3
00
65
00
8
G
O:
00
35
65
0
G
O:
00
al_p ,COL2A1,BCL6,VAPB,GPAA1,CLNS1A,SMAD7,USP4,ATP6V1D,SYTL4,
roce DGKA,ARPC4ss
TTLL3,LEF1,GLS,PAX8,BCL2L11,XBP1,NISCH,HSD17B12,ADAM8,CAP
ZB,PRPF40A,DNAJC10,CD9,SIPA1L1,KRIT1,PDLIM5,PTPN6,ACTR3,P
RKACA,DHX9,PLK1,APLNR,TXNL1,PTGES2,RC3H1,NPC1,SLC11A2,C
NP,CLN8,CAMK2D,SLC16A1,BBS1,JAM2,GIGYF2,SLC38A2,TPCN2,HP
S4,PAIP1,SNCAIP,SGK1,SLC9A5,MDM2,FKBP1A,PRKCH,TLN2,SSH2,
CREB1,NPTN,QSOX1,LCP2,NF1,SERBP1,NPR1,CAPN10,PKD2,ITGA3,
RB1,LTBP4,GNAI1,USP3,ZFPM2,TXNDC5,PAFAH1B1,IL18,ESAM,STA
RD3,TPP1,AACS,ARPC2,SYNE1,ANXA5,BICD1,GCC2,NR1H3,PLK2,H
EXA,FLCN,NRP1,TXNDC15,TENC1,FAP,PTEN,FYN,ALDH1A3,IQGAP1,
FBXW7,PHPT1,HERPUD1,IKBKB,NCOR1,ATP11B,MEF2A,OXCT1,TTC
7A,FECH,WASH4P,VILL,ABCA2,RAB8A,CSK,CP,PTPRC,CDK6,AAK1,G
OPC,NCK2,CTSH,VPS45,ZSWIM7,ACD,SEMA4D,GNB3,CSF1R,ATP6V
0A1,OS9,DGKZ,SEPW1,ACTR2,P4HB,HSD17B4,KLC1,C1QTNF3,DDA
H1,EZR,FLNA,RAB5A,SUN2,MCOLN1,ENG,PCSK7,ARNT,NOX4,GAPD
H,ERCC1,GAA,SLC25A6,PDIA5,MDFI,CIRBP,NUBP1,CIZ1,ITGA5,RGS
2,LPCAT1,PDGFRB,RAD51B,RAP1B,RUNX1,SMARCA4,MFI2,TLN1,DO
CK8,GSK3A,NLGN2,NCOR2,TWF1,SFXN3,PDIA3,PHF21A,ACIN1,ROB
O2,CACNB3,PMP22,CLIC4,BRWD1,HBB,TGFBR3,SPCS3,VARS,LARS,
PKD1,PDPK1,USF1,FOXC1,SLC9A8,CD63,SSH1,PABPC1,WNK1,CLAS
P1,TENM4,GATA2,PABPN1
877
AP-1 adaptor complex binding
mol
ecul
ar_f
unct
ion
ARPC2
13.5
067
628
5
intramolecular lyase activity
mol
ecul
ar_f
ISYNA1
13.5
067
628
9
E
0
2
7.
4
0
E
0
2
7.
4
0
16
87
2
G
O:
00
18
47
8
G
O:
00
04
49
1
G
O:
00
04
82
0
G
O:
00
52
92
6
unct
ion
malonate-semialdehyde dehydrogenase
(acetylating) activity
mol
ecul
ar_f
unct
ion
methylmalonate-semialdehyde
dehydrogenase (acylating) activity
mol
ecul
ar_f
unct
ion
glycine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha1,2-mannosyltransferase activity
mol
ecul
ar_f
unct
ion
5
ALDH6A1
13.5
067
628
5
ALDH6A1
13.5
067
628
5
GARS
13.5
067
628
5
ALG9
13.5
067
628
5
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
04
50
4
G
O:
00
19
78
0
G
O:
00
70
40
1
G
O:
00
01
64
8
G
O:
00
71
peptidylglycine monooxygenase activity
mol
ecul
ar_f
unct
ion
FAT10 activating enzyme activity
mol
ecul
ar_f
unct
ion
NADP+ binding
mol
ecul
ar_f
unct
ion
proteinase activated receptor activity
mol
ecul
ar_f
unct
ion
K6-linked polyubiquitin binding
mol
ecul
ar_f
unct
PAM
13.5
067
628
5
UBA6
13.5
067
628
5
GMDS
13.5
067
628
5
BICD1
13.5
067
628
5
UBXN1
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
79
6
G
O:
00
05
16
9
G
O:
00
35
60
5
G
O:
00
52
73
9
G
O:
00
04
36
1
ion
neurotrophin TRKB receptor binding
mol
ecul
ar_f
unct
ion
peptidyl-cysteine S-nitrosylase activity
mol
ecul
ar_f
unct
ion
phosphatidylserine 1-acylhydrolase activity
mol
ecul
ar_f
unct
ion
glutaryl-CoA dehydrogenase activity
mol
ecul
ar_f
unct
ion
BDNF
13.5
067
628
5
GAPDH
13.5
067
628
5
PLA2G16
13.5
067
628
5
GCDH
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
01
08
3
RNA polymerase II basal transcription factor
binding transcription factor activity
mol
ecul
ar_f
unct
ion
NAD+ synthase (glutamine-hydrolyzing)
activity
mol
ecul
ar_f
unct
ion
glutamate 5-kinase activity
mol
ecul
ar_f
unct
ion
G
O:
00
72
57
2
poly-ADP-D-ribose binding
mol
ecul
ar_f
unct
ion
G
O:
00
15
cadmium ion transmembrane transporter
activity
mol
ecul
ar_f
unct
G
O:
00
03
95
2
G
O:
00
04
34
9
TCF4
13.5
067
628
5
NADSYN1
13.5
067
628
5
ALDH18A1
13.5
067
628
5
RNF146
13.5
067
628
5
SLC11A2
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
08
6
G
O:
00
50
29
0
G
O:
00
01
08
7
G
O:
00
71
16
4
G
O:
00
51
80
0
ion
sphingomyelin phosphodiesterase D activity
mol
ecul
ar_f
unct
ion
TFIIB-class binding transcription factor
activity
mol
ecul
ar_f
unct
ion
RNA trimethylguanosine synthase activity
mol
ecul
ar_f
unct
ion
phosphatidylinositol-3,4-bisphosphate 3phosphatase activity
mol
ecul
ar_f
unct
ion
SMPD4
13.5
067
628
5
TCF4
13.5
067
628
5
TGS1
13.5
067
628
5
PTEN
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
30
61
6
transforming growth factor beta receptor,
common-partner cytoplasmic mediator
activity
mol
ecul
ar_f
unct
ion
inositol-1,3,4,5-tetrakisphosphate 3phosphatase activity
mol
ecul
ar_f
unct
ion
HLA-A specific activating MHC class I
receptor activity
mol
ecul
ar_f
unct
ion
G
O:
00
30
58
6
[methionine synthase] reductase activity
mol
ecul
ar_f
unct
ion
G
O:
00
51
mannose-ethanolamine phosphotransferase
activity
mol
ecul
ar_f
unct
G
O:
00
51
71
7
G
O:
00
30
10
8
SMAD4
13.5
067
628
5
PTEN
13.5
067
628
5
CTSH
13.5
067
628
5
MTRR
13.5
067
628
5
PIGG
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
37
7
G
O:
00
33
89
7
G
O:
00
33
85
8
G
O:
00
03
95
1
G
O:
00
04
68
6
ion
ribonuclease T2 activity
mol
ecul
ar_f
unct
ion
N-acetylgalactosamine kinase activity
mol
ecul
ar_f
unct
ion
NAD+ kinase activity
mol
ecul
ar_f
unct
ion
elongation factor-2 kinase activity
mol
ecul
ar_f
unct
ion
RNASET2
13.5
067
628
5
GALK2
13.5
067
628
5
NADK
13.5
067
628
5
EEF2K
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
70
12
3
G
O:
00
04
87
4
G
O:
00
51
99
0
G
O:
00
16
73
1
G
O:
00
19
transforming growth factor beta receptor
activity, type III
mol
ecul
ar_f
unct
ion
aryl hydrocarbon receptor activity
mol
ecul
ar_f
unct
ion
(R)-2-hydroxyglutarate dehydrogenase
activity
mol
ecul
ar_f
unct
ion
oxidoreductase activity, acting on iron-sulfur
proteins as donors, NAD or NADP as
acceptor
mol
ecul
ar_f
unct
ion
Atg8 ligase activity
mol
ecul
ar_f
unct
TGFBR3
13.5
067
628
5
ARNT
13.5
067
628
5
D2HGDH
13.5
067
628
5
FDXR
13.5
067
628
5
ATG3
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
77
6
G
O:
00
15
13
0
G
O:
00
04
14
9
G
O:
00
08
47
8
G
O:
00
50
14
5
ion
mevalonate transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
dihydrolipoyllysine-residue
succinyltransferase activity
mol
ecul
ar_f
unct
ion
pyridoxal kinase activity
mol
ecul
ar_f
unct
ion
nucleoside phosphate kinase activity
mol
ecul
ar_f
unct
ion
SLC16A1
13.5
067
628
5
DLST
13.5
067
628
5
PDXK
13.5
067
628
5
DTYMK
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
08
97
3
G
O:
00
16
97
1
G
O:
00
33
98
9
G
O:
00
70
83
5
G
O:
00
16
phosphopentomutase activity
mol
ecul
ar_f
unct
ion
flavin-linked sulfhydryl oxidase activity
mol
ecul
ar_f
unct
ion
3alpha,7alpha,12alpha-trihydroxy-5betacholest-24-enoyl-CoA hydratase activity
mol
ecul
ar_f
unct
ion
chromium ion transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
S-succinyltransferase activity
mol
ecul
ar_f
unct
PGM2
13.5
067
628
5
QSOX1
13.5
067
628
5
HSD17B4
13.5
067
628
5
SLC11A2
13.5
067
628
5
DLST
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
75
1
G
O:
00
47
93
6
ion
glucose 1-dehydrogenase [NAD(P)] activity
mol
ecul
ar_f
unct
ion
inositol-3-phosphate synthase activity
mol
ecul
ar_f
unct
ion
G
O:
00
08
44
6
GDP-mannose 4,6-dehydratase activity
mol
ecul
ar_f
unct
ion
G
O:
00
70
62
6
(S)-2-(5-amino-1-(5-phospho-Dribosyl)imidazole-4-carboxamido)succinate
AMP-lyase (fumarate-forming) activity
mol
ecul
ar_f
unct
ion
G
O:
00
04
51
2
H6PD
13.5
067
628
5
ISYNA1
13.5
067
628
5
GMDS
13.5
067
628
5
ADSL
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
31
40
3
G
O:
00
45
12
7
G
O:
00
31
87
1
G
O:
00
01
01
1
G
O:
00
35
lithium ion binding
mol
ecul
ar_f
unct
ion
N-acetylglucosamine kinase activity
mol
ecul
ar_f
unct
ion
proteinase activated receptor binding
mol
ecul
ar_f
unct
ion
sequence-specific DNA binding RNA
polymerase recruiting transcription factor
activity
mol
ecul
ar_f
unct
ion
cardiolipin hydrolase activity
mol
ecul
ar_f
unct
PDXK
13.5
067
628
5
NAGK
13.5
067
628
5
BICD1
13.5
067
628
5
TCF4
13.5
067
628
5
PLD6
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
75
5
G
O:
00
01
09
3
G
O:
00
51
26
7
G
O:
00
33
92
5
G
O:
00
16
73
0
ion
TFIIB-class transcription factor binding
mol
ecul
ar_f
unct
ion
CP2 mannose-ethanolamine
phosphotransferase activity
mol
ecul
ar_f
unct
ion
mannosyl-glycoprotein endo-beta-Nacetylglucosaminidase activity
mol
ecul
ar_f
unct
ion
oxidoreductase activity, acting on iron-sulfur
proteins as donors
mol
ecul
ar_f
unct
ion
TCF4
13.5
067
628
5
PIGG
13.5
067
628
5
ENGASE
13.5
067
628
5
FDXR
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
15
09
4
lead ion transmembrane transporter activity
mol
ecul
ar_f
unct
ion
pyridoxamine-phosphate oxidase activity
mol
ecul
ar_f
unct
ion
acetoacetate-CoA ligase activity
mol
ecul
ar_f
unct
ion
G
O:
00
05
16
6
neurotrophin p75 receptor binding
mol
ecul
ar_f
unct
ion
G
O:
00
08
CDP-diacylglycerol-glycerol-3-phosphate 3phosphatidyltransferase activity
mol
ecul
ar_f
unct
G
O:
00
04
73
3
G
O:
00
30
72
9
SLC11A2
13.5
067
628
5
PNPO
13.5
067
628
5
AACS
13.5
067
628
5
NTRK1
13.5
067
628
5
PGS1
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
44
4
G
O:
00
04
59
8
G
O:
00
00
25
7
G
O:
00
08
10
8
G
O:
00
70
18
1
ion
peptidylamidoglycolate lyase activity
mol
ecul
ar_f
unct
ion
nitrilase activity
mol
ecul
ar_f
unct
ion
UDP-glucose:hexose-1-phosphate
uridylyltransferase activity
mol
ecul
ar_f
unct
ion
SSU rRNA binding
mol
ecul
ar_f
unct
ion
PAM
13.5
067
628
5
NIT1
13.5
067
628
5
GALT
13.5
067
628
5
CIRBP
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
15
01
9
heparan-alpha-glucosaminide Nacetyltransferase activity
mol
ecul
ar_f
unct
ion
erythropoietin receptor activity
mol
ecul
ar_f
unct
ion
glycerophosphocholine phosphodiesterase
activity
mol
ecul
ar_f
unct
ion
G
O:
00
04
32
6
tetrahydrofolylpolyglutamate synthase
activity
mol
ecul
ar_f
unct
ion
G
O:
00
04
N6-(1,2-dicarboxyethyl)AMP AMP-lyase
(fumarate-forming) activity
mol
ecul
ar_f
unct
G
O:
00
04
90
0
G
O:
00
47
38
9
HGSNAT
13.5
067
628
5
EPOR
13.5
067
628
5
GPCPD1
13.5
067
628
5
FPGS
13.5
067
628
5
ADSL
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
01
8
ion
G
O:
00
16
81
5
mol
ecul
hydrolase activity, acting on carbon-nitrogen
ar_f
(but not peptide) bonds, in nitriles
unct
ion
G
O:
00
04
32
4
ferredoxin-NADP+ reductase activity
mol
ecul
ar_f
unct
ion
Fas-activated serine/threonine kinase
activity
mol
ecul
ar_f
unct
ion
amino acid kinase activity
mol
ecul
ar_f
unct
ion
G
O:
00
33
86
7
G
O:
00
19
20
2
NIT1
13.5
067
628
5
FDXR
13.5
067
628
5
FASTK
13.5
067
628
5
ALDH18A1
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
08
49
3
tetracycline transporter activity
mol
ecul
ar_f
unct
ion
formate transmembrane transporter activity
mol
ecul
ar_f
unct
ion
2-alkenal reductase [NAD(P)] activity
mol
ecul
ar_f
unct
ion
G
O:
00
44
59
4
17-beta-hydroxysteroid dehydrogenase
(NAD+) activity
mol
ecul
ar_f
unct
ion
G
O:
00
33
10-hydroxy-9(phosphonooxy)octadecanoate
phosphatase activity
mol
ecul
ar_f
unct
G
O:
00
15
49
9
G
O:
00
32
44
0
MFSD10
13.5
067
628
5
SLC26A6
13.5
067
628
5
PTGR1
13.5
067
628
5
HSD17B4
13.5
067
628
5
EPHX2
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
88
5
G
O:
00
04
49
2
G
O:
00
31
71
5
G
O:
00
01
09
1
G
O:
00
04
67
6
ion
methylmalonyl-CoA decarboxylase activity
mol
ecul
ar_f
unct
ion
C5L2 anaphylatoxin chemotactic receptor
binding
mol
ecul
ar_f
unct
ion
RNA polymerase II basal transcription factor
binding
mol
ecul
ar_f
unct
ion
3-phosphoinositide-dependent protein
kinase activity
mol
ecul
ar_f
unct
ion
ECHDC1
13.5
067
628
5
C3
13.5
067
628
5
TCF4
13.5
067
628
5
PDPK1
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
52
91
8
G
O:
00
47
28
8
G
O:
00
51
43
5
G
O:
00
04
74
7
G
O:
00
08
dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha1,2-mannosyltransferase activity
mol
ecul
ar_f
unct
ion
monosialoganglioside sialyltransferase
activity
mol
ecul
ar_f
unct
ion
BH4 domain binding
mol
ecul
ar_f
unct
ion
ribokinase activity
mol
ecul
ar_f
unct
ion
integrase activity
mol
ecul
ar_f
unct
ALG9
13.5
067
628
5
ST3GAL4
13.5
067
628
5
PXN
13.5
067
628
5
RBKS
13.5
067
628
5
PPFIBP2
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
90
7
G
O:
00
04
35
0
G
O:
00
32
39
7
G
O:
00
03
87
4
G
O:
00
08
11
6
ion
glutamate-5-semialdehyde dehydrogenase
activity
mol
ecul
ar_f
unct
ion
activating MHC class I receptor activity
mol
ecul
ar_f
unct
ion
6-pyruvoyltetrahydropterin synthase activity
mol
ecul
ar_f
unct
ion
prostaglandin-I synthase activity
mol
ecul
ar_f
unct
ion
ALDH18A1
13.5
067
628
5
CTSH
13.5
067
628
5
PTS
13.5
067
628
5
PTGIS
13.5
067
628
5
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
G
O:
00
15
03
9
NADPH-adrenodoxin reductase activity
mol
ecul
ar_f
unct
ion
1-acyl-2-lysophosphatidylserine
acylhydrolase activity
mol
ecul
ar_f
unct
ion
2,3-cyclic-nucleotide 3-phosphodiesterase
activity
mol
ecul
ar_f
unct
ion
G
O:
00
71
93
3
Arp2/3 complex binding
mol
ecul
ar_f
unct
ion
G
O:
00
15
vanadium ion transmembrane transporter
activity
mol
ecul
ar_f
unct
G
O:
00
52
74
0
G
O:
00
04
11
3
FDXR
13.5
067
628
5
PLA2G16
13.5
067
628
5
CNP
13.5
067
628
5
ARPC2
13.5
067
628
5
SLC11A2
13.5
067
628
5
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
0
2
7.
4
0
E
10
0
G
O:
00
05
98
5
G
O:
00
71
30
1
G
O:
20
01
22
3
G
O:
00
21
95
6
ion
sucrose metabolic process
biol
ogic
al_p GAA
roce
ss
13.4
726
324
9
cellular response to vitamin B1
biol
ogic
al_p MDM2
roce
ss
13.4
726
324
9
negative regulation of neuron migration
biol
ogic
al_p SRGAP2
roce
ss
13.4
726
324
9
central nervous system interneuron
axonogenesis
biol
ogic
al_p TCTN1
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
48
07
5
G
O:
00
43
00
4
G
O:
00
60
87
3
G
O:
00
71
21
5
G
O:
20
00
positive regulation of eye pigmentation
biol
ogic
al_p HPS4
roce
ss
13.4
726
324
9
cytoplasmic sequestering of CFTR protein
biol
ogic
al_p GOPC
roce
ss
13.4
726
324
9
anterior semicircular canal development
biol
ogic
al_p GLI3
roce
ss
13.4
726
324
9
cellular response to abscisic acid stimulus
biol
ogic
al_p LANCL2
roce
ss
13.4
726
324
9
regulation of neutrophil extravasation
biol
ogic
ADAM8
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
38
9
G
O:
00
60
98
1
G
O:
00
46
27
2
G
O:
00
45
58
3
G
O:
00
60
38
0
ss
cell migration involved in coronary
angiogenesis
biol
ogic
al_p PDGFRB
roce
ss
13.4
726
324
9
stilbene catabolic process
biol
ogic
al_p EPHX2
roce
ss
13.4
726
324
9
regulation of cytotoxic T cell differentiation
biol
ogic
al_p SART1
roce
ss
13.4
726
324
9
regulation of single-stranded telomeric DNA
binding
biol
ogic
al_p ACD
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
46
90
1
G
O:
00
97
05
1
G
O:
00
97
15
1
G
O:
00
15
90
4
G
O:
00
35
tetrahydrofolylpolyglutamate biosynthetic
process
biol
ogic
al_p FPGS
roce
ss
13.4
726
324
9
establishment of protein localization to
endoplasmic reticulum membrane
biol
ogic
al_p RAB10
roce
ss
13.4
726
324
9
positive regulation of inhibitory postsynaptic
membrane potential
biol
ogic
al_p NLGN2
roce
ss
13.4
726
324
9
tetracycline transport
biol
ogic
al_p MFSD10
roce
ss
13.4
726
324
9
N-terminal peptidyl-serine methylation
biol
ogic
NTMT1
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
57
0
G
O:
00
72
36
5
G
O:
00
35
64
4
G
O:
00
60
87
5
G
O:
00
14
07
6
ss
regulation of cellular ketone metabolic
process by negative regulation of
transcription from RNA polymerase II
promoter
biol
ogic
al_p NCOR2
roce
ss
13.4
726
324
9
phosphoanandamide dephosphorylation
biol
ogic
al_p PTPN22
roce
ss
13.4
726
324
9
lateral semicircular canal development
biol
ogic
al_p GLI3
roce
ss
13.4
726
324
9
response to fluoxetine
biol
ogic
al_p BDNF
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
36
11
1
G
O:
20
00
80
7
G
O:
00
46
36
0
G
O:
00
51
65
8
G
O:
00
51
very long-chain fatty-acyl-CoA metabolic
process
biol
ogic
al_p HSD17B4
roce
ss
13.4
726
324
9
regulation of synaptic vesicle clustering
biol
ogic
al_p PTEN
roce
ss
13.4
726
324
9
2-oxobutyrate biosynthetic process
biol
ogic
al_p THNSL2
roce
ss
13.4
726
324
9
maintenance of nucleus location
biol
ogic
al_p CIZ1
roce
ss
13.4
726
324
9
spindle pole body organization
biol
ogic
BNIP2
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
30
0
G
O:
00
72
68
0
G
O:
00
21
89
7
G
O:
00
09
44
3
G
O:
00
71
47
7
ss
extracellular matrix-dependent thymocyte
migration
biol
ogic
al_p ADAM8
roce
ss
13.4
726
324
9
forebrain astrocyte development
biol
ogic
al_p NF1
roce
ss
13.4
726
324
9
pyridoxal 5-phosphate salvage
biol
ogic
al_p PDXK
roce
ss
13.4
726
324
9
cellular hypotonic salinity response
biol
ogic
al_p SLC12A6
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
48
25
0
G
O:
00
46
36
1
G
O:
00
60
69
1
G
O:
00
21
76
8
G
O:
00
70
mitochondrial iron ion transport
biol
ogic
al_p SLC25A37
roce
ss
13.4
726
324
9
2-oxobutyrate metabolic process
biol
ogic
al_p THNSL2
roce
ss
13.4
726
324
9
epithelial cell maturation involved in salivary
gland development
biol
ogic
al_p XBP1
roce
ss
13.4
726
324
9
nucleus accumbens development
biol
ogic
al_p ALDH1A3
roce
ss
13.4
726
324
9
Hsp90 deacetylation
biol
ogic
HDAC6
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
84
6
G
O:
00
07
38
7
G
O:
00
43
51
9
G
O:
00
22
01
2
G
O:
20
00
41
3
ss
anterior compartment pattern formation
biol
ogic
al_p PBX3
roce
ss
13.4
726
324
9
regulation of myosin II filament organization
biol
ogic
al_p ACTR3
roce
ss
13.4
726
324
9
subpallium cell proliferation in forebrain
biol
ogic
al_p GLI3
roce
ss
13.4
726
324
9
regulation of fibronectin-dependent
thymocyte migration
biol
ogic
al_p ADAM8
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
71
90
9
G
O:
00
60
36
7
G
O:
00
72
68
1
G
O:
00
18
01
2
G
O:
00
72
determination of stomach left/right
asymmetry
biol
ogic
al_p NPHP3
roce
ss
13.4
726
324
9
sagittal suture morphogenesis
biol
ogic
al_p GLI3
roce
ss
13.4
726
324
9
fibronectin-dependent thymocyte migration
biol
ogic
al_p ADAM8
roce
ss
13.4
726
324
9
N-terminal peptidyl-alanine trimethylation
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
cortical collecting duct development
biol
ogic
PKD2
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
05
9
G
O:
00
60
97
8
ss
angiogenesis involved in coronary vascular
morphogenesis
biol
ogic
al_p PDGFRB
roce
ss
13.4
726
324
9
G
O:
00
43
69
7
cell dedifferentiation
biol
ogic
al_p CDK6
roce
ss
13.4
726
324
9
G
O:
20
00
62
2
regulation of nuclear-transcribed mRNA
catabolic process, nonsense-mediated
decay
biol
ogic
al_p PABPC1
roce
ss
13.4
726
324
9
negative regulation of fat cell proliferation
biol
ogic
al_p GATA2
roce
ss
13.4
726
324
9
G
O:
00
70
34
5
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
35
63
8
signal maturation
biol
ogic
al_p DISP1
roce
ss
13.4
726
324
9
maltose metabolic process
biol
ogic
al_p GAA
roce
ss
13.4
726
324
9
metanephric distal tubule morphogenesis
biol
ogic
al_p PKD1
roce
ss
13.4
726
324
9
G
O:
00
02
08
6
diaphragm contraction
biol
ogic
al_p GAA
roce
ss
13.4
726
324
9
G
O:
00
46
positive regulation of mitotic centrosome
separation
biol
ogic
RANBP1
al_p
roce
13.4
726
324
9
G
O:
00
00
02
3
G
O:
00
72
28
7
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
60
4
G
O:
00
31
03
8
G
O:
00
72
21
4
G
O:
00
90
07
1
G
O:
00
70
86
8
ss
myosin II filament organization
biol
ogic
al_p ACTR3
roce
ss
13.4
726
324
9
metanephric cortex development
biol
ogic
al_p PKD2
roce
ss
13.4
726
324
9
negative regulation of ribosome biogenesis
biol
ogic
al_p PTEN
roce
ss
13.4
726
324
9
heterochromatin organization involved in
chromatin silencing
biol
ogic
al_p BAZ2A
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
60
82
9
G
O:
00
71
49
4
G
O:
00
46
90
0
G
O:
00
43
18
1
G
O:
00
09
negative regulation of canonical Wnt
receptor signaling pathway involved in
neural plate anterior/posterior pattern
formation
biol
ogic
al_p TBX18
roce
ss
13.4
726
324
9
cellular response to UV-C
biol
ogic
al_p MDM2
roce
ss
13.4
726
324
9
tetrahydrofolylpolyglutamate metabolic
process
biol
ogic
al_p FPGS
roce
ss
13.4
726
324
9
vacuolar sequestering
biol
ogic
al_p GAA
roce
ss
13.4
726
324
9
abscisic acid mediated signaling pathway
biol
ogic
LANCL2
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
73
8
G
O:
00
15
72
8
G
O:
19
00
27
6
G
O:
19
00
12
2
G
O:
00
70
62
7
ss
mevalonate transport
biol
ogic
al_p SLC16A1
roce
ss
13.4
726
324
9
regulation of proteinase activated receptor
activity
biol
ogic
al_p BICD1
roce
ss
13.4
726
324
9
positive regulation of receptor binding
biol
ogic
al_p NRP1
roce
ss
13.4
726
324
9
ferrous iron import
biol
ogic
al_p SLC11A2
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
70
98
2
L-asparagine metabolic process
biol
ogic
al_p ASNS
roce
ss
13.4
726
324
9
G
O:
00
70
86
9
heterochromatin assembly involved in
chromatin silencing
biol
ogic
al_p BAZ2A
roce
ss
13.4
726
324
9
G
O:
20
00
62
3
negative regulation of nuclear-transcribed
mRNA catabolic process, nonsensemediated decay
biol
ogic
al_p PABPC1
roce
ss
13.4
726
324
9
positive regulation of male germ cell
proliferation
biol
ogic
al_p IL18
roce
ss
13.4
726
324
9
nucleoside monophosphate phosphorylation
biol
ogic
DTYMK
al_p
roce
13.4
726
324
9
G
O:
20
00
25
6
G
O:
00
46
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
94
0
G
O:
19
01
20
8
G
O:
00
90
14
9
G
O:
00
21
89
6
G
O:
00
15
67
6
ss
negative regulation of heart looping
biol
ogic
al_p TBX2
roce
ss
13.4
726
324
9
membrane fission involved in mitochondrial
fission
biol
ogic
al_p DNM1L
roce
ss
13.4
726
324
9
forebrain astrocyte differentiation
biol
ogic
al_p NF1
roce
ss
13.4
726
324
9
vanadium ion transport
biol
ogic
al_p SLC11A2
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
07
38
8
G
O:
20
00
87
2
G
O:
00
09
18
3
G
O:
00
35
10
5
G
O:
00
51
posterior compartment specification
biol
ogic
al_p PBX3
roce
ss
13.4
726
324
9
positive regulation of progesterone
secretion
biol
ogic
al_p RUNX1
roce
ss
13.4
726
324
9
purine deoxyribonucleoside diphosphate
biosynthetic process
biol
ogic
al_p AK5
roce
ss
13.4
726
324
9
sterol regulatory element binding protein
import into nucleus
biol
ogic
al_p LMNA
roce
ss
13.4
726
324
9
inactivation of MAPKK activity
biol
ogic
IGF1R
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
38
9
G
O:
20
00
61
2
G
O:
00
06
42
6
G
O:
00
36
26
1
G
O:
00
09
58
9
ss
regulation of thyroid-stimulating hormone
secretion
biol
ogic
al_p PAX8
roce
ss
13.4
726
324
9
glycyl-tRNA aminoacylation
biol
ogic
al_p GARS
roce
ss
13.4
726
324
9
7-methylguanosine cap hypermethylation
biol
ogic
al_p TGS1
roce
ss
13.4
726
324
9
detection of UV
biol
ogic
al_p FECH
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
70
46
0
G
O:
00
60
30
1
G
O:
19
00
48
3
G
O:
19
01
20
7
G
O:
00
44
thyroid-stimulating hormone secretion
biol
ogic
al_p PAX8
roce
ss
13.4
726
324
9
positive regulation of cytokine activity
biol
ogic
al_p NRP1
roce
ss
13.4
726
324
9
regulation of protein targeting to vacuolar
membrane
biol
ogic
al_p VAMP7
roce
ss
13.4
726
324
9
regulation of heart looping
biol
ogic
al_p TBX2
roce
ss
13.4
726
324
9
protein targeting to vacuolar membrane
biol
ogic
VAMP7
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
39
5
G
O:
00
18
01
1
G
O:
00
71
89
4
G
O:
19
01
62
9
G
O:
20
01
24
6
ss
N-terminal peptidyl-alanine methylation
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
histone H2B conserved C-terminal lysine
ubiquitination
biol
ogic
al_p WAC
roce
ss
13.4
726
324
9
regulation of presynaptic membrane
organization
biol
ogic
al_p PTEN
roce
ss
13.4
726
324
9
negative regulation of phosphatidylcholine
biosynthetic process
biol
ogic
al_p LPCAT1
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
07
07
2
positive regulation of transcription on exit
from mitosis
biol
ogic
al_p SIRT7
roce
ss
13.4
726
324
9
positive regulation of fibronectin-dependent
thymocyte migration
biol
ogic
al_p ADAM8
roce
ss
13.4
726
324
9
renal cortex development
biol
ogic
al_p PKD2
roce
ss
13.4
726
324
9
G
O:
00
09
81
0
stilbene metabolic process
biol
ogic
al_p EPHX2
roce
ss
13.4
726
324
9
G
O:
00
60
negative regulation of growth hormone
receptor signaling pathway
biol
ogic
LEPROT
al_p
roce
13.4
726
324
9
G
O:
20
00
41
5
G
O:
00
72
05
5
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
40
0
G
O:
00
18
03
2
ss
protein amidation
biol
ogic
al_p PAM
roce
ss
13.4
726
324
9
peptidyl-alanine modification
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
G
O:
00
09
73
7
response to abscisic acid stimulus
biol
ogic
al_p LANCL2
roce
ss
13.4
726
324
9
G
O:
00
31
58
7
positive regulation of inositol 1,4,5trisphosphate-sensitive calcium-release
channel activity
biol
ogic
al_p PKD2
roce
ss
13.4
726
324
9
G
O:
00
18
19
4
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
71
95
5
G
O:
19
00
73
7
G
O:
00
60
36
6
G
O:
00
35
60
6
G
O:
00
51
recycling endosome to Golgi transport
biol
ogic
al_p GCC2
roce
ss
13.4
726
324
9
negative regulation of phospholipase Cactivating G-protein coupled receptor
signaling pathway
biol
ogic
al_p BICD1
roce
ss
13.4
726
324
9
lambdoid suture morphogenesis
biol
ogic
al_p GLI3
roce
ss
13.4
726
324
9
peptidyl-cysteine S-trans-nitrosylation
biol
ogic
al_p GAPDH
roce
ss
13.4
726
324
9
establishment of centrosome localization
biol
ogic
PAFAH1B1
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
66
0
G
O:
00
31
28
9
G
O:
00
06
17
3
G
O:
00
09
78
9
G
O:
00
70
89
9
ss
actin phosphorylation
biol
ogic
al_p TWF1
roce
ss
13.4
726
324
9
dADP biosynthetic process
biol
ogic
al_p AK5
roce
ss
13.4
726
324
9
positive regulation of abscisic acid mediated
signaling pathway
biol
ogic
al_p LANCL2
roce
ss
13.4
726
324
9
mitochondrial tRNA wobble uridine
modification
biol
ogic
al_p MTO1
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
45
58
5
positive regulation of cytotoxic T cell
differentiation
biol
ogic
al_p SART1
roce
ss
13.4
726
324
9
negative regulation of energy homeostasis
biol
ogic
al_p FLCN
roce
ss
13.4
726
324
9
peptidyl-histidine dephosphorylation
biol
ogic
al_p PHPT1
roce
ss
13.4
726
324
9
G
O:
00
61
46
7
basolateral protein localization
biol
ogic
al_p RAB10
roce
ss
13.4
726
324
9
G
O:
00
03
lamellipodium assembly involved in
ameboidal cell migration
biol
ogic
SRGAP2
al_p
roce
13.4
726
324
9
G
O:
20
00
50
6
G
O:
00
35
97
1
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
36
3
G
O:
00
35
61
1
G
O:
00
15
72
4
G
O:
00
15
69
2
G
O:
00
03
37
3
ss
protein branching point deglutamylation
biol
ogic
al_p AGBL5
roce
ss
13.4
726
324
9
formate transport
biol
ogic
al_p SLC26A6
roce
ss
13.4
726
324
9
lead ion transport
biol
ogic
al_p SLC11A2
roce
ss
13.4
726
324
9
dynamin polymerization involved in
membrane fission
biol
ogic
al_p DNM1L
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
35
57
2
G
O:
00
03
37
4
G
O:
00
16
34
0
G
O:
00
43
99
0
G
O:
00
00
N-terminal peptidyl-serine dimethylation
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
dynamin polymerization involved in
mitochondrial fission
biol
ogic
al_p DNM1L
roce
ss
13.4
726
324
9
calcium-dependent cell-matrix adhesion
biol
ogic
al_p TRPM7
roce
ss
13.4
726
324
9
histone H2A-S1 phosphorylation
biol
ogic
al_p RPS6KA5
roce
ss
13.4
726
324
9
ribosomal large subunit export from nucleus
biol
ogic
SDAD1
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
05
5
G
O:
00
10
90
4
G
O:
00
06
19
3
G
O:
00
10
57
1
G
O:
00
09
78
7
ss
regulation of UDP-glucose catabolic
process
biol
ogic
al_p GSK3A
roce
ss
13.4
726
324
9
ITP catabolic process
biol
ogic
al_p ITPA
roce
ss
13.4
726
324
9
positive regulation of DNA replication
involved in S phase
biol
ogic
al_p INO80
roce
ss
13.4
726
324
9
regulation of abscisic acid mediated
signaling pathway
biol
ogic
al_p LANCL2
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
19
01
21
1
negative regulation of cardiac chamber
formation
biol
ogic
al_p TBX2
roce
ss
13.4
726
324
9
G
O:
00
60
82
7
regulation of canonical Wnt receptor
signaling pathway involved in neural plate
anterior/posterior pattern formation
biol
ogic
al_p TBX18
roce
ss
13.4
726
324
9
G
O:
00
72
36
2
regulation of glycolysis by negative
regulation of transcription from RNA
polymerase II promoter
biol
ogic
al_p NCOR1
roce
ss
13.4
726
324
9
G
O:
00
72
34
7
response to anesthetic
biol
ogic
al_p BDNF
roce
ss
13.4
726
324
9
G
O:
00
42
regulation of Golgi to plasma membrane
CFTR protein transport
biol
ogic
GOPC
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
99
9
G
O:
00
48
05
8
G
O:
20
00
63
8
G
O:
00
36
35
1
G
O:
00
60
09
6
ss
compound eye corneal lens development
biol
ogic
al_p CTNS
roce
ss
13.4
726
324
9
regulation of SREBP signaling pathway
biol
ogic
al_p FBXW7
roce
ss
13.4
726
324
9
histone H2A-K13 ubiquitination
biol
ogic
al_p RNF168
roce
ss
13.4
726
324
9
serotonin secretion, neurotransmission
biol
ogic
al_p XBP1
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
43
53
8
regulation of actin phosphorylation
biol
ogic
al_p TWF1
roce
ss
13.4
726
324
9
negative regulation of Golgi to plasma
membrane CFTR protein transport
biol
ogic
al_p GOPC
roce
ss
13.4
726
324
9
positive regulation of neutrophil
extravasation
biol
ogic
al_p ADAM8
roce
ss
13.4
726
324
9
G
O:
00
61
44
1
renal artery morphogenesis
biol
ogic
al_p PKD2
roce
ss
13.4
726
324
9
G
O:
00
60
positive regulation of single-stranded
telomeric DNA binding
biol
ogic
ACD
al_p
roce
13.4
726
324
9
G
O:
00
43
00
2
G
O:
20
00
39
1
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
38
1
G
O:
00
07
22
5
G
O:
00
35
56
8
G
O:
00
42
53
9
G
O:
00
90
14
8
ss
patched ligand maturation
biol
ogic
al_p DISP1
roce
ss
13.4
726
324
9
N-terminal peptidyl-proline methylation
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
hypotonic salinity response
biol
ogic
al_p SLC12A6
roce
ss
13.4
726
324
9
membrane fission
biol
ogic
al_p DNM1L
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
48
21
3
Golgi vesicle prefusion complex stabilization
biol
ogic
al_p COG4
roce
ss
13.4
726
324
9
negative regulation of SREBP signaling
pathway
biol
ogic
al_p FBXW7
roce
ss
13.4
726
324
9
negative regulation of phospholipase C
activity
biol
ogic
al_p BICD1
roce
ss
13.4
726
324
9
G
O:
20
00
80
8
negative regulation of synaptic vesicle
clustering
biol
ogic
al_p PTEN
roce
ss
13.4
726
324
9
G
O:
20
00
negative regulation of hepatocyte
proliferation
biol
ogic
FBXW7
al_p
roce
13.4
726
324
9
G
O:
20
00
63
9
G
O:
19
00
27
5
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
34
6
G
O:
00
31
65
8
G
O:
19
01
63
0
G
O:
00
34
69
6
G
O:
00
90
34
1
ss
negative regulation of cyclin-dependent
protein kinase activity involved in G1/S
biol
ogic
al_p PTEN
roce
ss
13.4
726
324
9
negative regulation of presynaptic
membrane organization
biol
ogic
al_p PTEN
roce
ss
13.4
726
324
9
response to prostaglandin F stimulus
biol
ogic
al_p YY1
roce
ss
13.4
726
324
9
negative regulation of secretion of
lysosomal enzymes
biol
ogic
al_p NR1H3
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
36
35
2
G
O:
00
03
01
1
G
O:
00
06
59
2
G
O:
00
70
98
1
G
O:
00
43
histone H2A-K15 ubiquitination
biol
ogic
al_p RNF168
roce
ss
13.4
726
324
9
involuntary skeletal muscle contraction
biol
ogic
al_p GAA
roce
ss
13.4
726
324
9
ornithine biosynthetic process
biol
ogic
al_p ALDH18A1
roce
ss
13.4
726
324
9
L-asparagine biosynthetic process
biol
ogic
al_p ASNS
roce
ss
13.4
726
324
9
dedifferentiation
biol
ogic
CDK6
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
69
6
G
O:
00
72
21
9
G
O:
20
00
41
8
G
O:
00
06
48
0
G
O:
00
18
01
6
ss
metanephric cortical collecting duct
development
biol
ogic
al_p PKD2
roce
ss
13.4
726
324
9
positive regulation of eosinophil migration
biol
ogic
al_p ADAM8
roce
ss
13.4
726
324
9
N-terminal protein amino acid methylation
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
N-terminal peptidyl-proline dimethylation
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
G
O:
00
22
01
8
G
O:
00
35
57
3
G
O:
00
10
90
5
G
O:
00
71
90
8
G
O:
19
01
lateral ganglionic eminence cell proliferation
biol
ogic
al_p GLI3
roce
ss
13.4
726
324
9
N-terminal peptidyl-serine trimethylation
biol
ogic
al_p NTMT1
roce
ss
13.4
726
324
9
negative regulation of UDP-glucose
catabolic process
biol
ogic
al_p GSK3A
roce
ss
13.4
726
324
9
determination of intestine left/right
asymmetry
biol
ogic
al_p NPHP3
roce
ss
13.4
726
324
9
regulation of cardiac chamber formation
biol
ogic
TBX2
al_p
roce
13.4
726
324
9
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
0
2
7.
4
2
E
21
0
G
O:
00
19
22
0
G
O:
00
10
72
0
G
O:
00
01
95
2
ss
0
2
regulation of phosphate metabolic process
RAB3GAP2,ACADVL,IGF1R,MYO1D,SIRT2,RALGAPA2,RAF1,BCL6,ZF
P91,CNTF,EEF2K,VAPB,SMAD7,ARHGEF12,RBPMS,STARD13,XBP1,
ADAM8,DNAJC10,RANBP1,SIPA1L1,PTPN6,IGBP1,NOD1,PRKACA,PL
K1,ASNS,TBC1D2B,HDGF,CCNL1,TBC1D10B,SYMPK,FAM58A,TBC1D
14,TNK2,GIT2,STK4,FGFR1,ADCY4,TAB2,SEC31A,FKBP1A,PPM1F,FA
biol
M13A,NPTN,ZCCHC9,CCNL2,SNX13,NF1,NPR1,RPS6KA5,PKD2,LMN
ogic
A,RB1,MAPK8IP3,PAFAH1B1,SENP2,TPP1,SYTL2,ACAP2,SH3BP5,RG
al_p
S3,GRB10,FLCN,NRP1,ARHGAP9,PTEN,IQGAP1,FBXW7,HERPUD1,P
roce
XN,SRGAP2,MEF2A,FECH,PRKRIP1,CSK,PTPRC,TBCD,ARHGAP29,S
ss
GSM3,PAK1,NCK2,SEMA4D,CSF1R,C3,SMAD4,TBC1D22A,TMED2,AK
5,ENG,NOX4,ARHGEF7,PDIA5,ASAP1,MDFI,ITGA5,RGS2,LPCAT1,PD
GFRB,CARD14,FARP1,TNFRSF14,YIF1A,TLN1,GSK3A,TWF1,IGF2,PD
CD4,CRIPAK,CDK5RAP1,BNIP2,NTRK1,SPRED1,TNFRSF10B,DUSP6,
PKD1,PDPK1,CDK5RAP3,RAPGEF6,WNK1
positive regulation of cell development
biol
ogic
BDNF,LEF1,PAX8,ACTR3,CAPRIN1,PRKCH,NPTN,PAFAH1B1,ARPC2,
al_p
SMARCD3,SEMA4D,SMAD4,TGFB1I1,GLI3,PTPRD,ROBO2,TENM4
roce
ss
1.45
882
007
9
regulation of cell-matrix adhesion
biol
ogic
al_p UTRN,BCL6,MINK1,PPM1F,NF1,PLEKHA2,PTEN,CDK6
roce
ss
1.79
635
099
9
1.13
453
747
3
7.
4
5
E
0
2
7.
4
5
E
0
2
7.
4
5
E
0
2
G
O:
00
46
49
6
G
O:
00
19
36
2
G
O:
00
51
27
0
G
O:
00
06
40
1
G
O:
00
05
nicotinamide nucleotide metabolic process
biol
ogic
al_p H6PD,FDXR,NADSYN1,NADK,FMO2,IDH1,IDH3B
roce
ss
1.88
616
854
9
pyridine nucleotide metabolic process
biol
ogic
al_p H6PD,FDXR,NADSYN1,NADK,FMO2,IDH1,IDH3B
roce
ss
1.88
616
854
9
regulation of cellular component movement
biol
ogic
al_p
roce
ss
IGF1R,LAMB1,RAF1,BCL6,SMAD7,HDAC6,LEF1,NISCH,ADAM8,KRIT1,
MINK1,IGBP1,JAG2,AAMP,SGK1,PPM1F,DDX58,PTPRK,NF1,COL18A1
,LMNA,NEXN,FLCN,NRP1,PTEN,PHPT1,SRGAP2,MYLK,PTPRC,CDK6,
RARRES2,SEMA6A,CTSH,SEMA4D,CSF1R,SUN2,ENG,NOX4,PDGFR
B,ELP6,CLIC4,TGFBR3,PDPK1,STK24
1.24
799
122
RNA catabolic process
biol
ogic RNASEH2B,XRN1,RNH1,UPF3A,UPF1,RC3H1,PAIP1,RNASET2,DIS3L,
al_p RPL27,EIF4B,RPL9,DDX6,PAN2,RPL24,RPL37A,RQCD1,PARN,RPL4,N
roce CBP2,RPLP0,PABPC1
ss
1.38
503
698
5
SNAP receptor activity
mol
ecul
ar_f
unct
2.45
577
506
4
VTI1A,STX16,STX2,STX18
7.
4
6
E
0
2
7.
4
6
E
0
2
7.
4
7
E
0
2
7.
4
9
E
0
2
7.
5
1
E
48
4
G
O:
00
05
77
5
G
O:
00
30
51
1
G
O:
00
51
29
3
G
O:
00
09
06
7
ion
vacuolar lumen
cell
ular
_co RNASET2,TXNDC5,TPP1,HEXA,LGMN,GUSB,PDGFRB,ACAN,FMOD
mpo
nent
1.72
520
479
4
positive regulation of transforming growth
factor beta receptor signaling pathway
biol
ogic
al_p FLCN,SMAD4,TGFB1I1,TGFBR3
roce
ss
2.44
956
954
4
establishment of spindle localization
biol
ogic
al_p NUMA1,PAFAH1B1,CDK5RAP2,CLASP1
roce
ss
2.44
956
954
4
aspartate family amino acid biosynthetic
process
biol
ogic
al_p EIF2B4,ASNS,MTRR,THNSL2
roce
ss
2.44
956
954
4
0
2
7.
5
1
E
0
2
7.
5
7
E
0
2
7.
5
7
E
0
2
7.
5
7
E
0
2
G
O:
00
01
82
3
G
O:
00
10
63
2
G
O:
00
01
88
5
G
O:
00
15
70
1
G
O:
00
42
mesonephros development
biol
ogic
al_p PAX8,PKD2,ZBTB16,PKD1
roce
ss
2.44
956
954
4
regulation of epithelial cell migration
biol
ogic
al_p HDAC6,PPM1F,CTSH,TGFBR3
roce
ss
2.44
956
954
4
endothelial cell development
biol
ogic
al_p PDE4D,COL18A1,ENG,CLIC4
roce
ss
2.44
956
954
4
bicarbonate transport
biol
ogic
al_p SLC26A6,SLC4A2,SLC4A4,CA5B,HBB
roce
ss
2.17
300
524
1
melanosome
cell
ular RAB35,CNP,HPS4,TPP1,SYTL2,FLOT1,ATP6V0A1,P4HB,RAB5A,CANX
_co ,PDIA3
mpo
1.62
028
005
8
7.
5
7
E
0
2
7.
5
7
E
0
2
7.
5
7
E
0
2
7.
5
9
E
0
2
7.
6
0
E
47
0
G
O:
00
48
77
0
G
O:
00
03
71
4
G
O:
00
97
36
7
G
O:
00
50
78
9
nent
pigment granule
cell
ular
RAB35,CNP,HPS4,TPP1,SYTL2,FLOT1,ATP6V0A1,P4HB,RAB5A,CANX
_co
,PDIA3
mpo
nent
1.62
028
005
8
transcription corepressor activity
mol
ecul
ar_f
unct
ion
NOC2L,SIN3B,HDGF,TBX18,DR1,HSF4,YY1,PFDN5,ZEB1,ZFPM2,NCO
R1,SETD8,TRIM28,UBP1,TCF4,PHF12,SMARCA4,NCOR2,LMCD1,TSG
101
1.40
695
446
3
carbohydrate derivative binding
mol
ecul
ar_f
unct
ion
ADAMTS1,HSD17B12,NOD1,HDGF,AAMP,FGFR1,THBS3,LTBP4,PAFA
H1B1,NRP1,PTPRF,PTPRC,RNF146,ABI3BP,LRPAP1,ENG,FGF14,CO
L13A1,TGFBR3,ACAN
1.40
695
446
3
regulation of biological process
FZD6,CDK14,USP10,CRBN,OBFC1,RAB3GAP2,PBX2,KANK2,CRIP2,A
CADVL,EIF2B4,CADM1,RAI1,PSMB10,CLMN,IGF1R,LAMB1,NPHP3,PT
biol
S,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,MYNN,TRNAU1A
ogic
P,BTN3A1,NOC2L,RAF1,NLRP1,ZNF131,SEPT5,GP1BB,F11R,LEPRE1
al_p
,PPP1R13B,GAS8,RSC1A1,SFSWAP,CDK13,BDNF,SIN3B,CPE,CBX5,
roce
PLCD1,SART1,COL2A1,RAB34,SUPT5H,SUPT20H,RILPL1,HLAss
DPB1,MARCH5,UBXN1,DPP4,LUC7L,BCL6,FUBP1,ZNF783,TBX2,PTP
N22,MMS19,SHMT2,ZFP91,CNTF,EEF2K,PLD1,VAPB,CUX1,NUP98,EE
1.03
379
110
7
0
2
7.
6
0
E
0
2
7.
6
3
E
0
2
7.
6
3
E
0
2
7.
6
7
E
0
2
D,FMR1,SMAD7,MCF2L,USP4,HDAC6,GLG1,ARHGEF12,EHMT1,ATP6
V1D,VRK2,RNH1,ZNF496,HGS,CASP4,DERL2,IL15RA,LANCL2,CD72,S
YTL4,DGKA,ARPC4-TTLL3,LEF1,GLS,PAX8,HLAC,SUPT4H1,ZNF83,PSMB9,EMX2,ITGA9,ARHGEF25,ADAMTS1,RGL4,
BCL2L13,BCL2L11,RBPMS,MEPE,STARD13,ZSCAN31,XBP1,NISCH,P
AM,SNRNP70,HSD17B12,HLADQA1,RAD23A,APITD1,MARK4,UHMK1,USP47,ADAM8,NOL3,CAPZB,
GABPB1,PRPF40A,DNAJC10,RAB35,XAF1,CD9,PCGF6,RANBP1,SIPA
1L1,KRIT1,MINK1,PDLIM5,RHOF,PTPN6,EEF1A1,ACTR3,LHX4,VASP,
CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC4,DHX9,PLK1,
APLNR,ZNF446,PDE7B,ASNS,TBC1D2B,COL16A1,JAG2,DNM1L,TXNL
1,PTGES2,UPF1,ZNF621,HDGF,RC3H1,PPP5C,NPC1,SHISA5,CCNL1,
RHOBTB1,HERC2,CHD6,ZC3H12A,NUP210,TBC1D10B,SEPT4,MIB2,S
LC11A2,SYMPK,AAMP,FAM58A,RAB24,ATG4B,IL13RA1,CLN8,TBX18,
LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,ZNF721,ZNF397,JHDM1D
,ZNF710,PLCB4,JAM2,GIGYF2,TBC1D14,TNK2,USP20,GIT2,WAC,STK
4,ZNF142,FUBP3,TRO,ZNF540,TPCN2,FGFR1,HPS4,RAB18,HSF4,C2,
CFB,DISP1,PAIP1,CAPRIN1,MMP16,ADCY4,CELF1,SNCAIP,PDE4D,P
AF1,TAB2,SGK1,PLEKHG4,SHARPIN,DPF2,TCHP,CPT1B,RNF8,KIAA0
586,SEC31A,MDM2,RHBDD1,FKBP1A,PRKCH,PPM1F,ZNF595,TBP,YY
1,FAM13A,INO80,GMEB2,SSH2,PFDN5,CREB1,NPTN,SRP9,RALGPS2
,FLII,TNFRSF25,PLEKHG5,QSOX1,RPRD1A,CCNDBP1,DDX58,ZCCHC
9,LCP2,CCNL2,PTPRK,SNX13,DFNA5,RHBDF1,SERPINH1,MAGI1,NF1
,ZEB1,EIF4B,CRIP1,SERBP1,NUB1,IFITM3,LGALS3BP,ASCC2,ATG12,
SPSB3,RGMB,COL18A1,RTKN,EBF1,MED28,NPR1,ZNF3,RPS6KA5,G3
BP1,NIPBL,RAB31,ALKBH3,BRD9,CAPN10,ZNF837,PKD2,CASP2,RXR
B,LMNA,RSL1D1,MITF,NOL8,ITGA3,RB1,PRMT5,LTBP4,MAPK8IP3,GN
AI1,USP3,PLEKHA2,MZF1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,
RNF168,PAFAH1B1,ZNF865,SENP2,IL18,PUM2,MTCH1,SLFN11,TPP1,
SYTL2,SUB1,PWP2,CHMP1A,PDE8A,AACS,ARPC2,STK38L,EPN2,AC
AP2,ZNF558,ANXA5,SH3BP5,USP33,ZNF263,ZNF180,BICD1,ZNF276,
RGS3,GCC2,NR1H3,CYTH2,GRB10,PLK2,USP7,PLD6,FLCN,NRP1,CU
L4A,ZNF605,CHFR,ZNF410,TXNDC15,TENC1,GMDS,IGFBP6,ARHGAP
9,SAP30BP,MAST2,STX2,FAP,VPS72,PTEN,FYN,ALDH1A3,SRPK1,RU
NX2,IQGAP1,C1R,FBXW7,PHPT1,LGMN,SMARCD3,HERPUD1,IFT172,
IKBKB,RQCD1,SNX17,PXN,ADAMTS18,KPNB1,SRGAP2,RFX7,LTBR,P
TPRF,NCOR1,PPP1R10,MEF2A,OXCT1,TNS1,FECH,LIFR,PRKRIP1,S
ETD8,SMEK1,WASH4P,ITGB5,TCTN1,NECAB3,PIAS2,FIBP,SSBP1,CA
CNB1,VILL,MAPK8,SH3BP2,MYCBP2,CLTCL1,UPK3B,MYLK,USP15,D
DX41,PBX3,HLAF,N6AMT1,ZNF565,ABCA2,RAB8A,AFF4,TRIM28,DENND4C,DMTF1,M
AP4K4,CSK,CDK5RAP2,PTPRS,PTPRC,OAZ1,PSMC6,TMEM66,TBCD,
RNF146,UBP1,CDK6,ABI3BP,RARRES2,WDR61,EBF4,NUP37,APPL2,Z
NF148,ZNF76,FLOT1,PSMC4,ARHGAP29,SGSM3,STAG2,UBA2,AAK1,
SP110,GOPC,IL10RA,PHKG2,PAK1,EVC,NCK2,LEPROT,LEPR,RAB10,
RHEB,SEMA6A,MTMR9,CTSH,ZSWIM7,TCF4,ACD,IKZF5,HMGN2,SEM
A4D,GNB3,SSBP2,CSF1R,ATP6V0A1,ERC1,TIMM50,DGKZ,SEPW1,AC
TR2,C3,NFYC,P4HB,PIWIL4,SRSF10,SS18,RCOR3,SMAD4,GRPEL2,F
NTB,CHURC1,CHURC1FNTB,TBC1D22A,MEMO1,ZNF114,MIER2,C1QTNF3,TGFB1I1
G
O:
00
00
20
9
G
O:
00
45
93
7
protein polyubiquitination
biol
ogic PSMB10,PPIL2,MARCH5,ZFP91,HDAC6,PSMB9,MARCH6,ANAPC4,SH
al_p ARPIN,RNF8,RNF168,CHFR,PSMC6,RNF146,PSMC4,AMFR,PSMA1,U
roce BR5
ss
1.43
495
494
positive regulation of phosphate metabolic
process
biol
ogic
al_p
roce
ss
ACADVL,IGF1R,RAF1,ZFP91,CNTF,VAPB,RBPMS,XBP1,ADAM8,IGBP
1,NOD1,PRKACA,PLK1,ASNS,HDGF,SYMPK,TNK2,STK4,FGFR1,ADC
Y4,TAB2,SEC31A,NPTN,NF1,NPR1,RPS6KA5,PKD2,LMNA,MAPK8IP3,
SENP2,TPP1,GRB10,FLCN,NRP1,IQGAP1,FBXW7,HERPUD1,PXN,CS
K,PTPRC,PAK1,SEMA4D,CSF1R,C3,SMAD4,ENG,NOX4,PDIA5,MDFI,I
TGA5,PDGFRB,CARD14,TNFRSF14,YIF1A,TLN1,GSK3A,IGF2,NTRK1,
TNFRSF10B,PKD1,PDPK1
1.19
975
267
5
7.
7
0
E
0
2
7.
7
6
E
0
2
G
O:
00
10
56
2
G
O:
00
50
66
0
G
O:
00
32
95
6
G
O:
00
30
01
0
G
O:
00
60
ACADVL,IGF1R,RAF1,ZFP91,CNTF,VAPB,RBPMS,XBP1,ADAM8,IGBP
1,NOD1,PRKACA,PLK1,ASNS,HDGF,SYMPK,TNK2,STK4,FGFR1,ADC
Y4,TAB2,SEC31A,NPTN,NF1,NPR1,RPS6KA5,PKD2,LMNA,MAPK8IP3,
SENP2,TPP1,GRB10,FLCN,NRP1,IQGAP1,FBXW7,HERPUD1,PXN,CS
K,PTPRC,PAK1,SEMA4D,CSF1R,C3,SMAD4,ENG,NOX4,PDIA5,MDFI,I
TGA5,PDGFRB,CARD14,TNFRSF14,YIF1A,TLN1,GSK3A,IGF2,NTRK1,
TNFRSF10B,PKD1,PDPK1
1.19
975
267
5
positive regulation of phosphorus metabolic
process
biol
ogic
al_p
roce
ss
flavin adenine dinucleotide binding
mol
ecul
ar_f
unct
ion
ACADVL,GCDH,FMO2,MTRR,NOX4,ETFA,SDHA,D2HGDH,MTO1
1.71
212
486
8
regulation of actin cytoskeleton organization
biol
ogic
al_p
roce
ss
ARPC4TTLL3,PAM,CAPZB,ACTR3,PPM1F,SSH2,ARPC2,PHPT1,MEF2A,WAS
H4P,VILL,PAK1,NCK2,CSF1R,ACTR2,FHOD1,NOX4,PDGFRB,TWF1,S
SH1
1.40
339
921
8
establishment of cell polarity
biol
ogic
IGF1R,KRIT1,SDCCAG8,NUMA1,PAFAH1B1,CDK5RAP2,RAB10,RAP1
al_p
B,CLASP1
roce
ss
1.70
779
848
5
bone morphogenesis
biol
ogic
COL9A1,COL2A1,GLG1,THBS3,RUNX2,MEF2A,EVC,GLI3,COL13A1
al_p
roce
1.70
779
848
5
7.
7
6
E
0
2
7.
7
7
E
0
2
7.
7
8
E
0
2
7.
8
7
E
0
2
7.
8
7
E
34
9
G
O:
00
15
98
0
G
O:
00
70
57
7
G
O:
00
09
06
6
G
O:
00
45
42
8
ss
energy derivation by oxidation of organic
compounds
biol
ogic
al_p
roce
ss
histone acetyl-lysine binding
mol
ecul
ar_f
unct
ion
aspartate family amino acid metabolic
process
biol
ogic
al_p EIF2B4,ASNS,GCDH,MTRR,DLST,THNSL2
roce
ss
1.97
160
475
5
regulation of nitric oxide biosynthetic
process
biol
ogic
al_p ZC3H12A,PKD2,DDAH1,PTGIS,HBB,DDAH2
roce
ss
1.97
160
475
5
ACADVL,BDNF,TAZ,PRKACA,ADCY4,IDH3G,ADSL,GRB10,IDH1,IQGA
P1,COX7A2L,PHKG2,LEPR,GNB3,DLST,ATP5A1,NDUFV1,NDUFS2,ET
FA,GAA,SLC25A6,SDHA,IDH3B,MLX,RAP1B,GSK3A,IGF2,PGM2,PHK
G1,SIRT3,SPCS3,UQCRH
1.29
466
738
7
BRD9,SMARCA4,BAZ2A
2.89
430
632
5
0
2
7.
9
6
E
0
2
7.
9
8
E
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
G
O:
00
55
01
0
ventricular cardiac muscle tissue
morphogenesis
biol
ogic
al_p SMAD7,FKBP1A,ZFPM2,GAA,TGFBR3,FOXC1
roce
ss
1.97
160
475
5
lymphocyte apoptotic process
biol
ogic
al_p NOC2L,BCL6,BCL2L11,ADAM8,PTEN,GLI3
roce
ss
1.97
160
475
5
cellular response to osmotic stress
biol
ogic
al_p PKD2,SLC12A6,MYLK
roce
ss
2.88
699
267
7
G
O:
00
06
19
8
cAMP catabolic process
biol
ogic
al_p PDE7B,PDE4D,PDE8A
roce
ss
2.88
699
267
7
G
O:
00
10
regulation of triglyceride biosynthetic
process
biol
ogic
NR1H3,FBXW7,C3
al_p
roce
2.88
699
267
7
G
O:
00
70
22
7
G
O:
00
71
47
0
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
2
E
86
6
G
O:
20
00
17
8
G
O:
00
03
32
3
G
O:
00
07
09
9
G
O:
00
00
13
2
ss
negative regulation of neural precursor cell
proliferation
biol
ogic
al_p BDNF,NF1,GATA2
roce
ss
2.88
699
267
7
type B pancreatic cell development
biol
ogic
al_p CDK6,GSK3A,PDPK1
roce
ss
2.88
699
267
7
centriole replication
biol
ogic
al_p CEP135,PLK2,CDK5RAP2
roce
ss
2.88
699
267
7
establishment of mitotic spindle orientation
biol
ogic
al_p NUMA1,PAFAH1B1,CDK5RAP2
roce
ss
2.88
699
267
7
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
G
O:
00
06
60
7
G
O:
00
72
16
3
G
O:
00
35
45
6
G
O:
00
44
06
5
G
O:
00
01
NLS-bearing substrate import into nucleus
biol
ogic
al_p KPNA6,KPNB1,KPNA1
roce
ss
2.88
699
267
7
mesonephric epithelium development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
2.88
699
267
7
response to interferon-beta
biol
ogic
al_p XAF1,IFITM3,DDX41
roce
ss
2.88
699
267
7
regulation of respiratory system process
biol
ogic
al_p GLS,PBX3,NLGN2
roce
ss
2.88
699
267
7
ruffle
cell
ular RAB34,TLN2,DDX58,MTMR14,CDK6,PAK1,TRPM7,EZR,RAB5A,ARHG
_co EF7,CTTN,ITGA5,TLN1,TWF1
mpo
1.50
697
376
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
2
E
0
2
8.
0
8
E
72
6
G
O:
00
21
76
6
G
O:
00
48
06
6
G
O:
00
34
33
3
G
O:
00
71
15
8
nent
hippocampus development
biol
ogic
al_p LEF1,EMX2,PAFAH1B1,PTEN,MEF2A,PTPRS,CDK6
roce
ss
1.84
918
485
2
developmental pigmentation
biol
ogic
al_p LEF1,BCL2L11,HPS4,MITF,BLOC1S5,MEF2A,GLI3
roce
ss
1.84
918
485
2
adherens junction assembly
biol
ogic
al_p SMAD7,PPM1F,PTPRK,PTEN,PXN,TBCD,PDPK1
roce
ss
1.84
918
485
2
positive regulation of cell cycle arrest
biol
ogic
PSMB10,PSMB9,PRKACA,MDM2,PKD2,CASP2,PSMC6,PSMC4,PSMA
al_p
1,RRP8
roce
ss
1.64
300
396
3
0
2
8.
1
2
E
0
2
8.
1
2
E
0
2
8.
1
2
E
0
2
8.
1
4
E
0
2
G
O:
00
00
78
1
G
O:
00
42
98
1
G
O:
00
32
50
2
chromosome, telomeric region
regulation of apoptotic process
developmental process
cell
ular
_co OBFC1,RNF8,TP53BP1,ACD,SUN2,ERCC1,NSMCE4A
mpo
nent
PSMB10,IGF1R,NOC2L,RAF1,NLRP1,PPP1R13B,BDNF,SART1,COL2A
1,BCL6,CNTF,SMAD7,HDAC6,CASP4,LEF1,PAX8,PSMB9,BCL2L13,BC
L2L11,USP47,ADAM8,NOL3,DNAJC10,KRIT1,LHX4,CSNK2A1,IGBP1,N
OD1,PLK1,ASNS,JAG2,DNM1L,SHISA5,SEPT4,SLC11A2,CLN8,BCLAF
biol
1,STK4,FGFR1,SGK1,DPF2,MDM2,RHBDD1,PRKCH,PPM1F,TNFRSF2
ogic
5,DFNA5,NF1,COL18A1,CAPN10,CASP2,LMNA,MITF,TXNDC5,IL18,MT
al_p
CH1,ANXA5,PLK2,FLCN,CUL4A,SAP30BP,PTEN,FYN,ALDH1A3,LGMN
roce
,HERPUD1,LTBR,MEF2A,MAPK8,PTPRC,PSMC6,PSMC4,CTSH,SEMA
ss
4D,TIMM50,ING4,GLI3,NOX4,ERCC1,TEX261,NRBP2,ARHGEF7,UNC5
B,ITGA5,CARD14,DIABLO,PDIA3,PTGIS,PSMA1,SON,BNIP2,NTRK1,T
NFRSF10B,DUSP6,ZBTB16,RRP8,PDPK1,FOXC1,DDAH2,STK24,FAST
K,BCL2L2-PABPN1,BCL2L2
FZD6,PBX2,CRIP2,EIF2B4,CADM1,RAI1,PSMB10,CKB,CLMN,IGF1R,L
AMB1,NPHP3,PTS,SIRT2,UTRN,RAF1,F11R,COL9A1,CDK13,BDNF,TA
Z,SIN3B,CPE,PLCD1,SART1,COL2A1,SUPT20H,MARCH5,LUC7L,BCL6
,TBX2,PTPN22,SPATA20,CNTF,CUX1,FMR1,SMAD7,BMP8A,GLG1,AR
biol HGEF12,EHMT1,RNH1,IL15RA,CD72,TTLL3,LEF1,PAX8,EMX2,ITGA9,
ogic ADAMTS1,BCL2L11,MEPE,XBP1,CPM,PAM,MARK4,UHMK1,ADAM8,C
al_p APZB,PRPF40A,CD9,SIPA1L1,KRIT1,MINK1,PDLIM5,PTPN6,ACTR3,L
roce HX4,VASP,CSNK2A1,PRKACA,SDCCAG8,ASNS,JAG2,DNM1L,RC3H1,
ss
CHD6,ZC3H12A,SEPT4,POLM,SLC11A2,DIP2A,AAMP,LSAMP,CNP,CL
N8,TBX18,JHDM1D,BBS1,GIGYF2,FLG,STK4,TRO,FGFR1,HPS4,RAB1
8,HSF4,DISP1,CAPRIN1,CELF1,PDE4D,PAF1,TAB2,SHARPIN,RNF8,KI
AA0586,RHBDD1,COL12A1,FKBP1A,PRKCH,DAZAP1,YY1,SSH2,THBS
3,PFDN5,CREB1,NPTN,FLII,ALDH6A1,DFNA5,NF1,ZEB1,CRIP1,NUMA
1.84
817
536
6
8.
1
7
E
0
2
1.14
212
440
1
8.
2
0
E
0
2
1.06
284
760
5
8.
2
5
E
0
2
1,RGMB,COL18A1,EBF1,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,GCNT2,
PKD2,CASP2,SLC12A6,RXRB,LMNA,MITF,ITGA3,RB1,LTBP4,MAPK8I
P3,ZFPM2,BLOC1S5,RNF168,PAFAH1B1,SENP2,IL18,MTCH1,TPP1,A
ACS,ARPC2,SYNE1,EPN2,ADAM15,USP33,BICD1,NR1H3,HEXA,USP7
,PLD6,FLCN,NRP1,TENC1,MAST2,STX2,VPS72,PTEN,FYN,ALDH1A3,I
DH1,SRPK1,RUNX2,IQGAP1,FBXW7,SMARCD3,IFT172,CTNS,RQCD1,
GGNBP2,PXN,SRGAP2,NCOR1,MEF2A,DYM,OXCT1,TTC7A,FECH,IT
GB5,TCTN1,SSBP1,CACNB1,MAPK8,MYCBP2,CLTCL1,MYLK,DDX41,
MAN1A2,PBX3,RAB8A,AFF4,TRIM28,CSK,CDK5RAP2,COL9A3,PTPRS
,PTPRC,SWAP70,IMPDH1,UBP1,CDK6,RARRES2,WDR61,EBF4,FLOT
1,PSMC4,STAG2,GOPC,RANBP9,WDR35,PAK1,EVC,NCK2,LEPR,RAB
10,SEMA6A,CTSH,TCF4,ACD,SEMA4D,CSF1R,ERC1,C3,HSD17B4,PI
WIL4,ROBO3,SS18,SMAD4,CHURC1,CHURC1FNTB,C1QTNF3,NAV1,TGFB1I1,DDAH1,LMBR1,DTYMK,EZR,CD276,N
R2C2,FLNA,RAB5A,ATP5A1,GLI3,TMED2,SDCBP2,MAPK12,EPN1,VEZ
T,ENG,TCF12,ARNT,NOX4,EXT1,ERCC1,GAA,BICC1,NRBP2,PRELID1
,STK36,SDHA,WWP1,ARHGEF7,TBCE,ASAP1,MED6,UNC5B,MDFI,PT
PRD,ITGA5,RGS2,HINFP,LPCAT1,PDGFRB,COL8A1,DZIP1,LGALS8,E
POR,CC2D2A,FARP1,CANX,RUNX1,MKNK2,SMARCA4,KIF13B,PTPN2
3,TLN1,FGF14,CD164,PHC3,GSK3A,ANKRD6,ITGA11,NLGN2,POLG,N
COR2,FPGS,SETD2,EMP1,COL13A1,IGF2,PTGIS,TROVE2,MYO1E,AT
XN3,GPHN,PDCD4,SOX13,STAT6,TANC1,ACIN1,PSD3,ROBO2,CACN
B3,PMP22,CLIC4,CDK5RAP1,BNIP2,NTRK1,SPATA6,SPRED1,BRWD1
,SMAD9,DUSP6,CTTNBP2,TGFBR3,TMEM237,ZBTB16,EGFL8,SEPT2,
PKD1,PDPK1,TSG101,FOXC1,ACAN,STK24,SEMA4B,SSH1,CDK5RAP
3,C2CD3,MMP25,EYA2,PHC2,WNK1,CLASP1,TENM4,GATA2,BCL2L2
G
O:
19
01
65
3
cellular response to peptide
biol
ogic IGF1R,RAF1,EEF2K,ATP6V1D,PTPN6,PRKACA,FGFR1,ADCY4,MDM2,
al_p EIF4B,RAB31,CAPN10,IL18,GRB10,FYN,PXN,DENND4C,CSK,PAK1,LE
roce PROT,RAB10,RHEB,GNB3,ATP6V0A1,GSK3A,IGF2,PDPK1,USF1
ss
1.31
440
317
8.
3
3
E
0
2
G
O:
00
71
37
5
cellular response to peptide hormone
stimulus
biol
ogic IGF1R,RAF1,EEF2K,ATP6V1D,PTPN6,PRKACA,FGFR1,ADCY4,MDM2,
al_p EIF4B,RAB31,CAPN10,IL18,GRB10,FYN,PXN,DENND4C,CSK,PAK1,LE
roce PROT,RAB10,RHEB,GNB3,ATP6V0A1,GSK3A,IGF2,PDPK1,USF1
ss
1.31
440
317
regulation of dephosphorylation
biol
ogic
MYO1D,IGBP1,SYMPK,FKBP1A,ZCCHC9,SYTL2,IQGAP1,MEF2A,SEM
al_p
A4D,PDGFRB,FARP1,SPRED1,WNK1
roce
ss
1.52
299
323
8
establishment or maintenance of cell
polarity
biol
ogic
IGF1R,KRIT1,ACTR3,SDCCAG8,NUMA1,LMNA,PAFAH1B1,CDK5RAP2
al_p
,RAB10,EZR,RAP1B,CLIC4,CLASP1
roce
ss
1.52
299
323
8
G
O:
00
16
59
3
Cdc73/Paf1 complex
cell
ular
_co PAF1,WDR61
mpo
nent
3.99
809
364
9
G
O:
cell-cell junction assembly
biol
ogic
1.68
407
G
O:
00
35
30
3
G
O:
00
07
16
3
F11R,CD9,PRKACA,PRKCH,TLN2,FLCN,TBCD,PARD6G,TLN1
8.
3
3
E
0
2
8.
4
1
E
0
2
8.
4
1
E
0
2
8.
4
2
E
0
2
8.
4
00
07
04
3
G
O:
00
16
88
7
G
O:
00
00
50
2
G
O:
00
14
89
7
G
O:
00
60
99
6
al_p
roce
ss
906
2
ATPase activity
mol
ecul
ar_f
unct
ion
CRBN,DHX34,MYO1D,ATP2B1,ATP6V1D,ABCC1,DDX23,DNAJC10,DD
X39A,SKIV2L,DHX9,UPF1,CHD6,PMS1,INO80,DDX58,G3BP1,DDX6,AT
P11B,DDX41,RNF213,ABCA2,PSMC6,SKIV2L2,PSMC4,GRPEL2,ATP5
A1,ATP8B2,RAD51B,SMARCA4,DHX40,LONRF3,MYO1E,CHD2,LONP2
,ACIN1,DHX37
proteasome complex
cell
ular
_co PSMB10,UBXN1,PSMB9,RAD23A,TXNL1,PSMC6,PSMC4,PSMA1
mpo
nent
1.74
916
597
2
striated muscle hypertrophy
biol
ogic
al_p CAMK2D,MEF2A,RGS2,GSK3A,LMCD1
roce
ss
2.10
509
882
7
dendritic spine development
biol
ogic
al_p SIPA1L1,PDLIM5,CAPRIN1,PTEN,SRGAP2
roce
ss
2.10
509
882
7
1.26
199
551
9
3
E
0
2
8.
4
5
E
0
2
8.
4
6
E
0
2
8.
4
7
E
0
2
8.
4
7
E
0
2
G
O:
00
03
30
0
G
O:
00
04
84
2
G
O:
00
51
33
6
G
O:
00
19
86
6
cardiac muscle hypertrophy
biol
ogic
al_p CAMK2D,MEF2A,RGS2,GSK3A,LMCD1
roce
ss
2.10
509
882
7
ubiquitin-protein ligase activity
mol
ecul
ar_f
unct
ion
1.28
635
836
7
regulation of hydrolase activity
RAB3GAP2,ACADVL,MYO1D,RALGAPA2,RAF1,NLRP1,BCL6,VAPB,AR
HGEF12,LEF1,BCL2L13,BCL2L11,STARD13,XBP1,USP47,DNAJC10,R
ANBP1,SIPA1L1,CSNK2A1,IGBP1,NOD1,PRKACA,ASNS,TBC1D2B,HD
biol
GF,TBC1D10B,SLC11A2,TBC1D14,GIT2,FGFR1,ADCY4,SEC31A,MDM
ogic
2,FKBP1A,PPM1F,FAM13A,CREB1,ZCCHC9,SNX13,SERPINH1,NF1,L
al_p
MNA,PAFAH1B1,MTCH1,TPP1,SYTL2,ACAP2,BICD1,RGS3,NR1H3,AR
roce
HGAP9,IQGAP1,HERPUD1,SRGAP2,MEF2A,SSBP1,MAPK8,TBCD,AR
ss
HGAP29,SGSM3,LEPR,CTSH,SEMA4D,C3,TBC1D22A,TMED2,ARHGE
F7,PDIA5,ASAP1,RGS2,PDGFRB,DIABLO,FARP1,YIF1A,TLN1,GSK3A,
BNIP2,NTRK1,SPRED1,TNFRSF10B,LMF1,CPAMD8,RAPGEF6,WNK1
organelle inner membrane
cell
ular
_co
mpo
nent
PSMB10,PPIL2,MARCH5,ZFP91,SMAD7,PSMB9,RNF220,MARCH6,AN
APC4,PLK1,RC3H1,HERC2,MIB2,RNF8,MDM2,UBE2Q1,RNF168,RNF2
17,CHFR,PTEN,MYCBP2,RNF213,TRIM28,PSMC6,RNF146,PSMC4,CD
C14B,WWP1,FBXW2,AMFR,PSMA1,UBR5
SLC25A37,ACADVL,TAZ,SHMT2,PGS1,TTC19,FDXR,HERC2,CNP,GC
DH,ALDH18A1,TIMM23,DHRS1,MTCH1,SRGAP2,ATP11B,FECH,ERAL
1,COX7A2L,TIMM50,GRPEL2,SUN2,BCS1L,ATP5A1,NDUFV1,NDUFS2
,SLC25A6,SDHA,LMNB1,LRPPRC,POLG,FPGS,SLC25A24,SLC25A46,L
ETM1,UQCRH
8.
4
7
E
0
2
8.
4
9
E
0
2
1.15
834
301
9
8.
5
1
E
0
2
1.26
572
814
8.
5
5
E
0
2
G
O:
00
05
54
5
1-phosphatidylinositol binding
mol
ecul
ar_f
unct
ion
PLEKHA3,MCF2L,PLEKHA2,WDFY3
2.34
900
223
5
nucleotide kinase activity
mol
ecul
ar_f
unct
ion
CMPK2,PNKP,DTYMK,AK5
2.34
900
223
5
blood vessel morphogenesis
biol
ogic
al_p
roce
ss
FZD6,PLCD1,TBX2,SMAD7,RNH1,LEF1,ADAM8,KRIT1,ZC3H12A,AAM
P,STK4,FGFR1,NF1,COL18A1,NPR1,PKD2,SLC12A6,ZFPM2,IL18,ADA
M15,NRP1,PTEN,FBXW7,MYLK,UBP1,CTSH,C3,DDAH1,ENG,ITGA5,P
DGFRB,COL8A1,RUNX1,SMARCA4,SETD2,PTGIS,MYO1E,CLIC4,NTR
K1,FOXC1,GATA2
1.24
409
444
2
G
O:
00
03
71
2
transcription cofactor activity
mol
ecul
ar_f
unct
ion
NOC2L,SIN3B,SUPT20H,MMS19,RBPMS,HDGF,TBX18,DR1,HSF4,YY1
,GMEB2,PFDN5,CREB1,ZEB1,RXRB,RB1,ZFPM2,TP53BP1,SUB1,NR1
H3,SMARCD3,RQCD1,NCOR1,MEF2A,SETD8,PIAS2,TRIM28,UBP1,TC
F4,NFYC,SS18,TGFB1I1,ING4,NR2C2,DCAF6,ARNT,PHF12,MED6,HIN
FP,SMARCA4,RAD54L2,NCOR2,LMCD1,TSG101
1.23
298
250
1
G
O:
regulation of triglyceride metabolic process
biol
ogic
NR1H3,FBXW7,C3,LMF1
2.34
306
G
O:
00
19
20
1
G
O:
00
48
51
4
8.
5
8
E
0
2
8.
5
8
E
0
2
8.
5
9
E
0
2
8.
6
4
E
0
2
8.
6
00
90
20
7
G
O:
00
61
38
4
G
O:
00
60
99
7
G
O:
00
34
40
5
G
O:
00
22
41
1
al_p
roce
ss
652
1
heart trabecula morphogenesis
biol
ogic
al_p ADAMTS1,FKBP1A,SMARCA4,TGFBR3
roce
ss
2.34
306
652
1
dendritic spine morphogenesis
biol
ogic
al_p SIPA1L1,PDLIM5,CAPRIN1,PTEN
roce
ss
2.34
306
652
1
response to fluid shear stress
biol
ogic
al_p SMAD7,PKD2,MEF2A,PDGFRB
roce
ss
2.34
306
652
1
cellular component disassembly
biol
ogic
al_p
roce
ss
1.30
235
447
4
DPP4,HDAC6,CAPZB,DNM1L,UPF1,MMP16,SHARPIN,RPL27,RPL9,LM
NA,PAFAH1B1,RPL24,RPL37A,FAP,SMARCD3,KPNB1,VILL,KLC1,RPL
4,ENG,MTRF1L,SMARCA4,LMNB1,RPLP0,TWF1,ACIN1,KPNA1,STK24
,CLASP1
5
E
0
2
8.
6
5
E
0
2
8.
6
5
E
0
2
8.
6
5
E
0
2
8.
6
5
E
0
2
G
O:
00
10
74
1
negative regulation of intracellular protein
kinase cascade
biol
ogic
IGF1R,HGS,PTPN6,IGBP1,NF1,PAFAH1B1,RGS3,FLCN,PTEN,NCOR1,
al_p
CSK,LEPROT,RGS2,PDCD4,SPRED1,DUSP6
roce
ss
1.44
672
563
7
negative regulation of epithelial cell
proliferation
biol
ogic
al_p KRIT1,NF1,RB1,PTEN,FBXW7,MEF2A,CDK6,ATP5A1,ENG,TGFBR3
roce
ss
1.62
320
873
4
regulation of epidermal growth factor
receptor signaling pathway
biol
ogic
al_p HGS,RHBDF1,FBXW7,NCK2,EPS15L1,EPN1,ARHGEF7,STAM2
roce
ss
1.73
840
419
3
G
O:
00
16
48
2
cytoplasmic transport
biol
ogic
al_p
roce
ss
BCL6,NUP98,HGS,RBPMS,UHMK1,DDX39A,KPNA6,PRKACA,NUTF2,U
PF1,VAMP7,CAMK2D,FYTTD1,BBS1,TPCN2,TIMM23,SEC31A,MDM2,F
KBP1A,SRP9,DDX58,RPL27,NF1,RPL9,RAB31,PKD2,LMNA,BLOC1S5,
GCC2,RPL24,RPL37A,KPNB1,PPP1R10,CSK,PTPRC,STX18,GOPC,RA
B10,TIMM50,SRSF10,SMAD4,GRPEL2,C1QTNF3,RPL4,FLNA,GLI3,TM
ED2,THOC2,SCFD1,SLC25A6,VAMP4,MDFI,NCBP2,TGS1,RPLP0,SDA
D1,SNX27,PDIA3,LONP2,LMF1,SPCS3,PKD1,KPNA1,UBR5,PABPN1
1.18
340
690
8
G
O:
podosome
cell
ular
ADAM8,ACTR3,TPM4
2.79
866
G
O:
00
50
68
0
G
O:
00
42
05
8
8.
6
5
E
0
2
8.
6
7
E
0
2
8.
6
7
E
0
2
8.
6
7
E
0
2
8.
6
00
02
10
2
G
O:
00
05
79
0
G
O:
00
16
51
4
G
O:
00
51
30
1
G
O:
00
19
22
1
_co
mpo
nent
555
5
smooth endoplasmic reticulum
cell
ular
_co MYO1D,PLCB4,MAPK8IP3
mpo
nent
2.79
866
555
5
SWI/SNF complex
cell
ular
_co RB1,SMARCD3,SMARCA4
mpo
nent
2.79
866
555
5
cell division
biol
ogic
al_p
roce
ss
CDK14,IGF1R,SIRT2,SEPT5,LEF1,APITD1,PRPF40A,RAB35,ACTR3,A
NAPC4,PLK1,TTC19,SEPT4,FGFR1,RNF8,ZFYVE26,ANAPC16,INO80,
NEK3,NUMA1,RB1,GNAI1,PAFAH1B1,CHMP1A,FLCN,CHFR,SETD8,D
SN1,CDK6,NUP37,STAG2,PARD6G,RAB10,CENPT,CDCA3,HAUS5,NC
APD3,IGF2,MAU2,SON,ZBTB16,SEPT2,TSG101,CLASP1
1.23
242
376
2
cytokine-mediated signaling pathway
biol
ogic
al_p
roce
ss
HLA-DPB1,CNTF,NUP98,VRK2,IL15RA,HLA-C,HLADQA1,XAF1,PTPN6,STAT2,NUP210,IL13RA1,CAMK2D,SHARPIN,TNF
RSF25,IFITM3,RPS6KA5,PAFAH1B1,NR1H3,RQCD1,KPNB1,LIFR,HLAF,PTPRC,NUP37,IL10RA,LEPR,CSF1R,IRF9,NUP85,EPOR,TNFRSF14,
STAT6,KPNA1,ZC3H15
1.26
758
639
1
9
E
0
2
8.
6
9
E
0
2
8.
6
9
E
0
2
8.
7
0
E
0
2
8.
7
2
E
0
2
G
O:
00
44
32
5
ion channel binding
mol
ecul
ar_f
unct
ion
USP10,FKBP1A,PKD2,FYN,PHPT1,GOPC,PKD1
1.81
821
807
6
cyclin-dependent protein kinase activity
mol
ecul
ar_f
unct
ion
CDK14,CDK13,PLK1,CCNL1,FAM58A,CCNL2,PKD2,PTEN,CDK6,CDK1
1A,CDK5RAP1,PKD1,CDK5RAP3
1.51
368
894
positive regulation of lymphocyte activation
biol
ogic SART1,HLA-DPB1,DPP4,BCL6,IL15RA,HLAal_p DQA1,ADAM8,PTPN6,IL18,FYN,MEF2A,CSK,PTPRC,PAK1,NCK2,CD27
roce 6,GLI3,LGALS8,TNFRSF14,IGF2,STAT6,PDPK1
ss
1.35
962
346
3
G
O:
00
08
65
4
phospholipid biosynthetic process
biol
ogic TAZ,PLD1,GPAA1,PGS1,FDPS,PIGS,PIGG,PIGN,CHKB,IDI1,GPAT2,IS
al_p YNA1,GPCPD1,PLD6,MTMR14,PTEN,MBOAT2,LPCAT1,PCYT1A,PIGO
roce ,ALG9,PLA2G16
ss
1.35
962
346
3
G
O:
positive regulation of T cell activation
biol
ogic
1.40
992
G
O:
00
04
69
3
G
O:
00
51
25
1
SART1,HLA-DPB1,DPP4,HLADQA1,ADAM8,PTPN6,IL18,FYN,CSK,PTPRC,PAK1,NCK2,CD276,GLI3,
8.
7
2
E
0
2
8.
7
3
E
0
2
8.
7
3
E
0
2
8.
7
3
E
0
2
8.
7
00
50
87
0
G
O:
00
05
08
5
G
O:
00
23
02
1
G
O:
00
43
48
7
G
O:
00
01
94
7
al_p LGALS8,TNFRSF14,IGF2,PDPK1
roce
ss
665
6
guanyl-nucleotide exchange factor activity
mol
ecul
ar_f
unct
ion
termination of signal transduction
biol
ogic
al_p ARHGEF12,SNX13,RGS3,RGS2,ADRBK2,SNX14
roce
ss
1.92
466
178
5
regulation of RNA stability
biol
ogic
al_p DHX9,RC3H1,PAIP1,SERBP1,CIRBP,PABPC1
roce
ss
1.92
466
178
5
heart looping
biol
ogic
al_p NPHP3,TBX2,PKD2,MEF2A,TMED2,ENG,C2CD3
roce
ss
1.81
362
360
5
EIF2B4,MCF2L,ARHGEF12,ARHGEF25,RGL4,HERC2,PLEKHG4,RALG
PS2,PLEKHG5,CYTH2,DENND4C,RASGRF2,ARHGEF7,FARP1,DOCK8
,RGL2,PSD3,RAPGEF6,DENND6B
1.39
472
007
7
7
E
0
2
8.
8
0
E
0
2
8.
8
0
E
0
2
8.
8
0
E
0
2
8.
8
2
E
0
2
G
O:
00
09
24
7
glycolipid biosynthetic process
biol
ogic
al_p GPAA1,PIGS,PIGG,PIGN,ST6GALNAC5,PIGO,ALG9
roce
ss
1.81
362
360
5
nucleobase-containing compound transport
biol
ogic
NUP98,FMR1,DDX39A,UPF3A,UPF1,NUP210,FYTTD1,SENP2,SLC35D
al_p
2,NUP37,SRSF10,SLC23A2,THOC2,NUP85,NCBP2,LRPPRC,PABPN1
roce
ss
1.42
257
610
2
aldehyde dehydrogenase [NAD(P)+] activity
mol
ecul
ar_f
unct
ion
ALDH1A3,ALDH3B1
3.85
907
51
G
O:
00
19
79
8
procollagen-proline dioxygenase activity
mol
ecul
ar_f
unct
ion
LEPRE1,P4HB
3.85
907
51
G
O:
phosphatidylinositol monophosphate
phosphatase activity
mol
ecul
MTMR14,PTEN
3.85
907
G
O:
00
15
93
1
G
O:
00
04
03
0
8.
8
2
E
0
2
8.
9
2
E
0
2
8.
9
6
E
0
2
8.
9
6
E
0
2
8.
9
00
52
74
4
G
O:
00
08
49
4
G
O:
00
31
99
4
G
O:
00
19
85
5
G
O:
00
04
43
8
ar_f
unct
ion
51
translation activator activity
mol
ecul
ar_f
unct
ion
PAIP1,PABPC1
3.85
907
51
insulin-like growth factor I binding
mol
ecul
ar_f
unct
ion
IGF1R,IGFBP6
3.85
907
51
calcium channel inhibitor activity
mol
ecul
ar_f
unct
ion
FKBP1A,PHPT1
3.85
907
51
phosphatidylinositol-3-phosphatase activity
mol
ecul
ar_f
unct
ion
MTMR14,PTEN
3.85
907
51
6
E
0
2
8.
9
6
E
0
2
8.
9
6
E
0
2
8.
9
6
E
0
2
8.
9
6
E
0
2
G
O:
00
05
11
4
type II transforming growth factor beta
receptor binding
mol
ecul
ar_f
unct
ion
regulation of extracellular matrix
disassembly
biol
ogic
al_p DPP4,FAP
roce
ss
3.84
932
357
pyrimidine deoxyribonucleotide biosynthetic
process
biol
ogic
al_p CMPK2,DTYMK
roce
ss
3.84
932
357
G
O:
00
34
75
5
iron ion transmembrane transport
biol
ogic
al_p SLC25A37,SLC11A2
roce
ss
3.84
932
357
G
O:
radial glial cell differentiation
biol
ogic
3.84
932
G
O:
00
10
71
5
G
O:
00
09
22
1
ENG,TGFBR3
LEF1,GLI3
3.85
907
51
8.
9
6
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
00
60
01
9
G
O:
00
09
30
4
G
O:
00
16
19
8
G
O:
00
32
87
5
G
O:
00
43
65
3
al_p
roce
ss
357
tRNA transcription
biol
ogic
al_p GTF3C2,GTF3C1
roce
ss
3.84
932
357
axon choice point recognition
biol
ogic
al_p ROBO3,ROBO2
roce
ss
3.84
932
357
regulation of DNA endoreduplication
biol
ogic
al_p FBXW7,STAG2
roce
ss
3.84
932
357
mitochondrial fragmentation involved in
apoptotic process
biol
ogic
al_p DNM1L,ATG3
roce
ss
3.84
932
357
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
G
O:
00
14
74
1
negative regulation of muscle hypertrophy
biol
ogic
al_p RGS2,GSK3A
roce
ss
3.84
932
357
paraxial mesoderm formation
biol
ogic
al_p LEF1,FOXC1
roce
ss
3.84
932
357
negative regulation of peptidyl-threonine
phosphorylation
biol
ogic
al_p SMAD7,SPRED1
roce
ss
3.84
932
357
G
O:
20
00
46
5
regulation of glycogen (starch) synthase
activity
biol
ogic
al_p GSK3A,IGF2
roce
ss
3.84
932
357
G
O:
negative regulation of lipoprotein particle
clearance
biol
ogic
3.84
932
G
O:
00
48
34
1
G
O:
00
10
80
1
CSK,LRPAP1
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
00
10
98
5
G
O:
00
32
81
7
G
O:
00
03
13
9
G
O:
00
07
18
5
G
O:
00
42
02
3
al_p
roce
ss
357
regulation of natural killer cell proliferation
biol
ogic
al_p PTPN22,IL18
roce
ss
3.84
932
357
secondary heart field specification
biol
ogic
al_p SMARCD3,MEF2A
roce
ss
3.84
932
357
transmembrane receptor protein tyrosine
phosphatase signaling pathway
biol
ogic
al_p PTPRF,PTPRD
roce
ss
3.84
932
357
DNA endoreduplication
biol
ogic
al_p FBXW7,STAG2
roce
ss
3.84
932
357
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
G
O:
00
48
28
9
isotype switching to IgE isotypes
biol
ogic
al_p BCL6,STAT6
roce
ss
3.84
932
357
attachment of GPI anchor to protein
biol
ogic
al_p GPAA1,PIGS
roce
ss
3.84
932
357
histone H3-K9 demethylation
biol
ogic
al_p JHDM1D,HSF4
roce
ss
3.84
932
357
G
O:
00
19
05
4
modulation by virus of host cellular process
biol
ogic
al_p BCL2L11,PABPN1
roce
ss
3.84
932
357
G
O:
regulation of clathrin-mediated endocytosis
biol
ogic
3.84
932
G
O:
00
16
25
5
G
O:
00
33
16
9
TNK2,AAK1
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
20
00
36
9
G
O:
20
01
22
2
G
O:
00
06
65
7
G
O:
00
51
78
8
G
O:
20
00
19
4
al_p
roce
ss
357
regulation of neuron migration
biol
ogic
al_p SRGAP2,SEMA6A
roce
ss
3.84
932
357
CDP-choline pathway
biol
ogic
al_p CHKB,PCYT1A
roce
ss
3.84
932
357
response to misfolded protein
biol
ogic
al_p HDAC6,ATXN3
roce
ss
3.84
932
357
regulation of female gonad development
biol
ogic
al_p ZFPM2,RUNX1
roce
ss
3.84
932
357
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
9.
0
0
E
0
2
G
O:
00
06
92
8
G
O:
00
51
17
4
G
O:
00
32
38
cellular component movement
regulation of phosphorus metabolic process
regulation of intracellular transport
IGF1R,AVL9,LAMB1,NPHP3,PPIL2,RAF1,F11R,SLC16A3,GAS8,DPP4,
BCL6,SMAD7,HDAC6,DYNC1I1,LEF1,EMX2,ITGA9,STARD9,NISCH,AP
3S2,ADAM8,CAPZB,PRPF40A,CD9,KRIT1,MINK1,PTPN6,ACTR3,IGBP
biol 1,JAG2,AAMP,SLC16A1,JAM2,FGFR1,PDE4D,SGK1,PPM1F,PLEKHG5
ogic ,DDX58,PTPRK,RHBDF1,NF1,TPM4,COL18A1,LMNA,ITGA3,BLOC1S5,
al_p NEXN,PAFAH1B1,ESAM,DNALI1,ARPC2,USP33,BICD1,FLCN,NRP1,F
roce AP,PTEN,FYN,PHPT1,PXN,SRGAP2,TNS1,MYLK,PTPRC,CDK6,RARR
ss
ES2,KIFC2,NCK2,SEMA6A,CTSH,SEMA4D,CSF1R,DGKZ,ACTR2,ROB
O3,KLC1,NAV1,DNHD1,SUN2,ACTR10,GLI3,ENG,NOX4,STK36,NUP85
,ITGA5,PDGFRB,ELP6,LRPPRC,KIF13B,TLN1,SETD2,PPAP2A,MYO1E
,AMFR,DYNC1I2,CLIC4,TGFBR3,CD151,PDPK1,FOXC1,STK24
RAB3GAP2,ACADVL,IGF1R,MYO1D,SIRT2,RALGAPA2,RAF1,BCL6,ZF
P91,CNTF,EEF2K,VAPB,SMAD7,ARHGEF12,RBPMS,STARD13,XBP1,
ADAM8,DNAJC10,RANBP1,SIPA1L1,PTPN6,IGBP1,NOD1,PRKACA,PL
K1,ASNS,TBC1D2B,HDGF,CCNL1,TBC1D10B,SYMPK,FAM58A,TBC1D
14,TNK2,GIT2,STK4,FGFR1,ADCY4,TAB2,SEC31A,FKBP1A,PPM1F,FA
biol
M13A,NPTN,ZCCHC9,CCNL2,SNX13,NF1,NPR1,RPS6KA5,PKD2,LMN
ogic
A,RB1,MAPK8IP3,PAFAH1B1,SENP2,TPP1,SYTL2,ACAP2,SH3BP5,RG
al_p
S3,GRB10,FLCN,NRP1,ARHGAP9,PTEN,IQGAP1,FBXW7,HERPUD1,P
roce
XN,SRGAP2,MEF2A,FECH,PRKRIP1,CSK,PTPRC,TBCD,ARHGAP29,S
ss
GSM3,PAK1,NCK2,SEMA4D,CSF1R,C3,SMAD4,TBC1D22A,TMED2,AK
5,ENG,NOX4,ARHGEF7,PDIA5,ASAP1,MDFI,ITGA5,RGS2,LPCAT1,PD
GFRB,CARD14,FARP1,TNFRSF14,YIF1A,TLN1,GSK3A,TWF1,IGF2,PD
CD4,CRIPAK,CDK5RAP1,BNIP2,NTRK1,SPRED1,TNFRSF10B,DUSP6,
PKD1,PDPK1,CDK5RAP3,RAPGEF6,WNK1
biol
ogic RBPMS,UHMK1,PRKACA,VAMP7,CAMK2D,MDM2,FKBP1A,DDX58,NF
al_p 1,CAPN10,PKD2,GCC2,ABCA2,CSK,GOPC,SMAD4,C1QTNF3,FLNA,G
roce LI3,SCFD1,VAMP4,MDFI,NCBP2,PKD1,KPNA1,UBR5
ss
1.13
651
199
6
9.
0
1
E
0
2
1.12
428
087
6
9.
0
3
E
0
2
1.31
687
385
3
9.
0
8
E
-
6
G
O:
00
00
77
9
condensed chromosome, centromeric
region
cell
ular
DYNC1I1,APITD1,PLK1,TP53BP1,DSN1,NUP37,CENPT,NUP85,SEPT2,
_co
CLASP1
mpo
nent
1.60
842
848
carbohydrate catabolic process
biol
ogic
GK5,H6PD,GALT,NCOR1,PHKG2,FUT4,ARNT,GAPDH,GAA,ENO4,GSK
al_p
3A,PGM2,CTBS,PHKG1,RBKS
roce
ss
1.45
388
120
4
chromosome organization
biol
ogic
al_p
roce
ss
OBFC1,SIRT2,NOC2L,SUPT5H,EED,HDAC6,EHMT1,LEF1,SUPT4H1,C
HD6,PCGF1,DR1,JHDM1D,WAC,HSF4,PAF1,RNF8,YY1,INO80,PHF15,
RPS6KA5,NIPBL,BRD9,RB1,PRMT5,USP3,RNF168,CHMP1A,MUM1,FL
CN,VPS72,SRPK1,FBXW7,SMARCD3,NCOR1,SETD8,MAPK8,ITPA,WD
R61,STAG2,ACD,HMGN2,CENPT,ING4,MSL1,SIRT7,ERCC1,PHF1,NC
APD3,SMARCA4,SETD2,KANSL3,ATXN3,MAU2,PHF21A,ACIN1,SHPR
H,BAZ2A,RRP8,PHF19,SENP6,UBR5,EYA2,SMARCAD1,GATA2
1.17
862
868
4
G
O:
00
46
57
8
regulation of Ras protein signal transduction
biol
ogic
al_p
roce
ss
RALGAPA2,RAF1,BCL6,MCF2L,ARHGEF12,ARHGEF25,SIPA1L1,TBC1
D2B,TBC1D10B,TBC1D14,GIT2,PLEKHG4,PLEKHG5,NF1,PAFAH1B1,
ACAP2,CYTH2,FLCN,IQGAP1,SRGAP2,FLOT1,ARHGAP29,SGSM3,SE
MA4D,DGKZ,TBC1D22A,RASGRF2,ARHGEF7,ASAP1,FARP1,PSD3,NT
RK1
1.27
551
550
2
G
O:
regulation of execution phase of apoptosis
biol
ogic
SART1,BCL2L11,DNAJC10,DNM1L,SEPT4,BCLAF1,DPF2,PPM1F,TNF
RSF25,CASP2,CUL4A,FYN,LTBR,MAPK8,TIMM50,UNC5B,DIABLO,TN
1.36
021
G
O:
00
16
05
2
G
O:
00
51
27
6
0
2
9.
1
2
E
0
2
9.
1
7
E
0
2
9.
2
1
E
0
2
9.
2
4
E
0
2
9.
2
19
00
11
7
G
O:
00
97
19
0
G
O:
00
10
92
3
G
O:
19
01
18
4
G
O:
00
34
10
1
al_p FRSF10B,RRP8,STK24,FASTK
roce
ss
770
4
apoptotic signaling pathway
biol
ogic SART1,BCL2L11,DNAJC10,DNM1L,SEPT4,BCLAF1,DPF2,PPM1F,TNF
al_p RSF25,CASP2,CUL4A,FYN,LTBR,MAPK8,TIMM50,UNC5B,DIABLO,TN
roce FRSF10B,RRP8,STK24,FASTK
ss
1.36
021
770
4
negative regulation of phosphatase activity
biol
ogic
al_p MYO1D,FKBP1A,ZCCHC9,SYTL2,SEMA4D,FARP1,SPRED1,WNK1
roce
ss
1.71
081
047
5
regulation of ERBB signaling pathway
biol
ogic
al_p HGS,RHBDF1,FBXW7,NCK2,EPS15L1,EPN1,ARHGEF7,STAM2
roce
ss
1.71
081
047
5
erythrocyte homeostasis
biol
ogic
BCL6,SLC11A2,RB1,NCOR1,FECH,CDK6,ARNT,SMARCA4,ACIN1,TGF
al_p
BR3,GATA2
roce
ss
1.55
998
902
6
8
E
0
2
9.
2
8
E
0
2
9.
3
2
E
0
2
9.
3
2
E
0
2
9.
3
3
E
0
2
G
O:
00
00
91
0
G
O:
00
43
08
5
G
O:
00
65
00
7
cytokinesis
positive regulation of catalytic activity
biological regulation
biol
ogic
IGF1R,SEPT5,PRPF40A,RAB35,ACTR3,PLK1,TTC19,SEPT4,ZFYVE26,
al_p
CHMP1A,FLCN,SON
roce
ss
RAB3GAP2,ACADVL,PSMB10,IGF1R,RALGAPA2,RAF1,NLRP1,ZFP91,
VAPB,ARHGEF12,PSMB9,BCL2L13,BCL2L11,STARD13,XBP1,ADAM8,
DNAJC10,RANBP1,SIPA1L1,NOD1,PRKACA,ANAPC4,PLK1,ASNS,TBC
biol 1D2B,HDGF,TBC1D10B,SLC11A2,TBC1D14,GIT2,STK4,FGFR1,MMP1
ogic 6,ADCY4,TAB2,SEC31A,PPM1F,FAM13A,CREB1,SNX13,NF1,PKD2,LM
al_p NA,MAPK8IP3,MTCH1,TPP1,ACAP2,RGS3,NR1H3,ARHGAP9,PTEN,IQ
roce GAP1,FBXW7,HERPUD1,PXN,SRGAP2,MEF2A,SSBP1,MAPK8,CSK,P
ss
TPRC,PSMC6,TBCD,PSMC4,ARHGAP29,SGSM3,UBA2,PAK1,CTSH,A
CD,SEMA4D,CSF1R,TBC1D22A,CDC14B,NOX4,ARHGEF7,PDIA5,ASA
P1,MDFI,RGS2,PDGFRB,CARD14,DIABLO,DBF4,YIF1A,TLN1,GSK3A,I
GF2,PSMA1,BNIP2,NTRK1,TNFRSF10B,LMF1,PKD1,PDPK1
FZD6,CDK14,USP10,SLC25A37,CRBN,OBFC1,RAB3GAP2,PBX2,KANK
2,CRIP2,ACADVL,EIF2B4,CADM1,RAI1,PSMB10,CKB,CLMN,IGF1R,LA
MB1,NPHP3,PTS,TNRC6A,MYO1D,SIRT2,EPHX2,UTRN,RALGAPA2,M
YNN,TRNAU1AP,BTN3A1,NOC2L,PPIL2,RAF1,NLRP1,ZNF131,SEPT5,
biol
GP1BB,F11R,LEPRE1,SLC16A3,PPP1R13B,GAS8,COL9A1,RSC1A1,S
ogic
FSWAP,CDK13,BDNF,SIN3B,ATP2B1,CPE,CBX5,PLCD1,SART1,COL2
al_p
A1,RAB34,SUPT5H,SUPT20H,RILPL1,HLAroce
DPB1,MARCH5,UBXN1,DPP4,LUC7L,BCL6,FUBP1,ZNF783,TBX2,PTP
ss
N22,MMS19,SHMT2,ZFP91,CNTF,EEF2K,PLD1,VAPB,GPAA1,CUX1,C
LNS1A,NUP98,EED,FMR1,SMAD7,MCF2L,USP4,HDAC6,GLG1,ARHGE
F12,EHMT1,ATP6V1D,VRK2,RNH1,ZNF496,HGS,CASP4,DERL2,IL15R
A,LANCL2,CD72,SYTL4,DGKA,ARPC4-TTLL3,LEF1,GLS,PAX8,HLA-
1.52
520
367
9
9.
3
6
E
0
2
1.14
073
091
5
9.
4
0
E
0
2
1.02
934
173
9.
4
0
E
0
2
C,SUPT4H1,ZNF83,PSMB9,EMX2,ITGA9,ARHGEF25,ADAMTS1,RGL4,
BCL2L13,BCL2L11,RBPMS,MEPE,STARD13,ZSCAN31,XBP1,NISCH,P
AM,SNRNP70,HSD17B12,HLADQA1,RAD23A,APITD1,MARK4,UHMK1,USP47,ADAM8,NOL3,CAPZB,
GABPB1,PRPF40A,DNAJC10,RAB35,XAF1,CD9,PCGF6,RANBP1,SIPA
1L1,KRIT1,MINK1,PDLIM5,RHOF,PTPN6,EEF1A1,ACTR3,LHX4,VASP,
CSNK2A1,IGBP1,UPF3A,NOD1,PRKACA,STAT2,ANAPC4,DHX9,PLK1,
APLNR,ZNF446,PDE7B,ASNS,TBC1D2B,COL16A1,JAG2,DNM1L,TXNL
1,PTGES2,UPF1,ZNF621,HDGF,RC3H1,PPP5C,NPC1,SHISA5,CCNL1,
RHOBTB1,HERC2,CHD6,ZC3H12A,NUP210,TBC1D10B,SEPT4,MIB2,S
LC11A2,SYMPK,AAMP,FAM58A,RAB24,ATG4B,IL13RA1,CNP,CLN8,TB
X18,LBX2,PCGF1,VAMP7,DR1,BCLAF1,CAMK2D,ZNF721,ZNF397,JHD
M1D,SLC16A1,ZNF710,PLCB4,BBS1,JAM2,GIGYF2,TBC1D14,TNK2,U
SP20,GIT2,WAC,STK4,ZNF142,FUBP3,TRO,ZNF540,SLC38A2,TPCN2,
FGFR1,HPS4,RAB18,HSF4,C2,CFB,DISP1,PAIP1,CAPRIN1,MMP16,AD
CY4,CELF1,SNCAIP,PDE4D,PAF1,TAB2,SGK1,PLEKHG4,SLC9A5,SHA
RPIN,DPF2,TCHP,CPT1B,RNF8,KIAA0586,SEC31A,MDM2,RHBDD1,FK
BP1A,PRKCH,PPM1F,ZNF595,TBP,YY1,FAM13A,TLN2,INO80,GMEB2,
SSH2,PFDN5,CREB1,NPTN,SRP9,RALGPS2,FLII,TNFRSF25,PLEKHG
5,QSOX1,RPRD1A,CCNDBP1,DDX58,ZCCHC9,LCP2,CCNL2,PTPRK,S
NX13,DFNA5,RHBDF1,SERPINH1,MAGI1,NF1,ZEB1,EIF4B,CRIP1,SER
BP1,NUB1,IFITM3,LGALS3BP,ASCC2,ATG12,SPSB3,RGMB,COL18A1,
RTKN,EBF1,MED28,NPR1,ZNF3,RPS6KA5,G3BP1,NIPBL,RAB31,ALKB
H3,BRD9,CAPN10,ZNF837,PKD2,CASP2,RXRB,LMNA,RSL1D1,MITF,N
OL8,ITGA3,RB1,PRMT5,LTBP4,MAPK8IP3,GNAI1,USP3,PLEKHA2,MZ
F1,ZFPM2,TP53BP1,BLOC1S5,TXNDC5,NEXN,RNF168,PAFAH1B1,ZN
F865,SENP2,IL18,PUM2,MTCH1,ESAM,SLFN11,STARD3,TPP1,SYTL2,
SUB1,PWP2,CHMP1A,PDE8A,AACS,ARPC2,SYNE1,STK38L,EPN2,AC
AP2,ZNF558,ANXA5,SH3BP5,USP33,ZNF263,ZNF180,BICD1,ZNF276,
RGS3,GCC2,NR1H3,CYTH2,GRB10,PLK2,HEXA,USP7,PLD6,FLCN,NR
P1,CUL4A,ZNF605,CHFR,ZNF410,TXNDC15,TENC1,GMDS,IGFBP6,A
RHGAP9,SAP30BP,MAST2,STX2,FAP,VPS72,PTEN,FYN,ALDH1A3,SR
PK1,RUNX2,IQGAP1,C1R,FBXW7,PHPT1,LGMN,SMARCD3,HERPUD1
,IFT172,IKBKB,RQCD1,SNX17,PXN,ADAMTS18,KPNB1,SRGAP2,RFX7
,LTBR,PTPRF,NCOR1,ATP11B,PPP1R10,MEF2A,OXCT1,TNS1,TTC7A,
FECH,LIFR,PRKRIP1,SETD8,SMEK1,WASH4P,ITGB5,TCTN1,NECAB3,
PIAS2,FIBP,SSBP1,CACNB1,VILL,MAPK8,SH3BP2,MYCBP2,CLTCL1,U
PK3B,MYLK,USP15,DDX41,PBX3,HLAF,N6AMT1,ZNF565,ABCA2,RAB8A,AFF4,TRIM28,DENND4C,DMTF1,M
AP4K4,CSK,CDK5RAP2,CP,PTPRS,PTPRC,OAZ1,PSMC6,TMEM66,TB
CD,RNF146,UBP1,CDK6,ABI3BP,RARRES2,WDR61,EBF4,NUP37,APP
L2,ZNF148,ZNF76,FLOT1,PSMC4,ARHGAP29,SGSM3,STAG2,UBA2,A
AK1,SP110,GOPC,IL10RA,PHKG2,PAK1,EVC,NCK2,LEPROT,LEPR,RA
B10,RHEB,SEMA6A,MTMR9,CTSH,VPS45,ZSWIM7,TCF4,ACD,IKZF5,
HMGN2,SEMA4D,GNB3,SSBP2,CSF1R,ATP6V0A1,ERC1
G
O:
00
50
85
3
G
O:
00
10
77
0
G
O:
00
51
86
B cell receptor signaling pathway
biol
ogic
al_p PTPN22,PTPN6,PRKCH,MEF2A,PTPRC
roce
ss
2.04
130
795
4
positive regulation of cell morphogenesis
involved in differentiation
biol
ogic
al_p LEF1,PAX8,ARPC2,SMAD4,TGFB1I1
roce
ss
2.04
130
795
4
protein autoubiquitination
biol
ogic
al_p MARCH5,RNF220,RNF8,RNF213,RNF146
roce
ss
2.04
130
795
4
9.
4
1
E
0
2
9.
4
1
E
0
2
9.
4
1
E
-
5
G
O:
00
30
09
7
hemopoiesis
biol
ogic
al_p
roce
ss
CRIP2,CDK13,TAZ,SART1,BCL6,PTPN22,IL15RA,LEF1,ADAM8,MINK1,
PTPN6,JAG2,RC3H1,POLM,SLC11A2,STK4,PAF1,NF1,ZEB1,MITF,RB1
,PAFAH1B1,FLCN,RUNX2,NCOR1,MEF2A,TTC7A,FECH,PTPRC,CDK6,
WDR61,CSF1R,GLI3,ARNT,ERCC1,LGALS8,RUNX1,MKNK2,SMARCA
4,CD164,MYO1E,STAT6,ACIN1,NTRK1,TGFBR3,ZBTB16,GATA2
1.21
538
143
4
ATP catabolic process
biol
ogic
al_p
roce
ss
CRBN,DHX34,MYO1D,ATP2B1,ATP6V1D,ABCC1,DDX23,DNAJC10,DD
X39A,SKIV2L,DHX9,UPF1,CHD6,PMS1,INO80,DDX58,G3BP1,DDX6,AT
P11B,DDX41,RNF213,ABCA2,PSMC6,SKIV2L2,PSMC4,GRPEL2,ATP5
A1,ATP8B2,RAD51B,SMARCA4,DHX40,LONRF3,MYO1E,CHD2,LONP2
,ACIN1,DHX37
1.24
934
186
NAD-dependent histone deacetylase
activity
mol
ecul
ar_f
unct
ion
SIRT2,HDAC6,SIRT7
2.70
135
257
G
O:
00
51
32
2
anaphase
biol
ogic
al_p ANAPC4,PLK1,NUMA1
roce
ss
2.69
452
649
9
G
O:
histone H4-K5 acetylation
biol
ogic
2.69
452
G
O:
00
06
20
0
G
O:
00
17
13
6
PHF15,ING4,KANSL3
0
2
9.
4
1
E
0
2
9.
4
3
E
0
2
9.
4
4
E
0
2
9.
5
0
E
0
2
9.
5
00
43
98
1
G
O:
00
43
98
2
G
O:
00
97
23
7
G
O:
00
02
90
2
G
O:
00
72
07
5
al_p
roce
ss
649
9
histone H4-K8 acetylation
biol
ogic
al_p PHF15,ING4,KANSL3
roce
ss
2.69
452
649
9
cellular response to toxin
biol
ogic
al_p MDM2,CRIP1,MEF2A
roce
ss
2.69
452
649
9
regulation of B cell apoptotic process
biol
ogic
al_p NOC2L,BCL6,PTEN
roce
ss
2.69
452
649
9
metanephric mesenchyme development
biol
ogic
al_p PKD2,SMAD4,PDGFRB
roce
ss
2.69
452
649
9
0
E
0
2
9.
5
0
E
0
2
9.
5
0
E
0
2
9.
5
0
E
0
2
9.
5
0
E
0
2
G
O:
00
48
07
0
regulation of developmental pigmentation
biol
ogic
al_p BCL2L11,HPS4,BLOC1S5
roce
ss
2.69
452
649
9
glucan biosynthetic process
biol
ogic
al_p GRB10,PHKG2,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.87
990
220
8
glycogen biosynthetic process
biol
ogic
al_p GRB10,PHKG2,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.87
990
220
8
G
O:
00
21
51
5
cell differentiation in spinal cord
biol
ogic
al_p LHX4,CLN8,GIGYF2,TCTN1,GLI3,GATA2
roce
ss
1.87
990
220
8
G
O:
cell aging
biol
ogic
1.63
856
G
O:
00
09
25
0
G
O:
00
05
97
8
MARCH5,TBX2,LMNA,PTEN,CDK6,ENG,NOX4,ERCC1,PDCD4
9.
5
0
E
0
2
9.
6
2
E
0
2
9.
6
2
E
0
2
9.
6
2
E
0
2
9.
6
00
07
56
9
G
O:
00
02
37
7
G
O:
00
21
76
1
G
O:
00
07
22
9
G
O:
00
00
27
9
al_p
roce
ss
341
1
immunoglobulin production
biol
ogic
al_p BCL6,POLM,RNF8,RNF168,GALNT2,PTPRC,SWAP70,ERCC1,STAT6
roce
ss
1.63
856
341
1
limbic system development
biol
ogic
al_p LEF1,EMX2,FGFR1,PAFAH1B1,PTEN,ALDH1A3,MEF2A,PTPRS,CDK6
roce
ss
1.63
856
341
1
integrin-mediated signaling pathway
biol
ogic
ITGA9,ADAMTS1,COL16A1,ITGA3,PXN,ADAMTS18,ITGB5,ITGA5,ITGA
al_p
11
roce
ss
1.63
856
341
1
M phase
biol
ogic
al_p
roce
ss
SIRT2,CDK13,NUP98,STARD9,APITD1,RANBP1,ANAPC4,PLK1,PPP5C
,PMS1,RNF8,ANAPC16,INO80,NEK3,NUMA1,NIPBL,RB1,PRMT5,PAFA
H1B1,CHMP1A,NTMT1,PLK2,PLD6,CHFR,PTEN,NCOR1,SETD8,CLTC
L1,DSN1,NUP37,STAG2,PIWIL4,CENPT,CDCA3,FLNA,SUN2,SIRT7,NU
P85,HAUS5,PDGFRB,NCAPD3,RAD51B,CDK11A,IGF2,MAU2,SEPT2,S
ENP6,CLASP1,GORASP1
1.20
687
201
5
3
E
0
2
9.
6
3
E
0
2
9.
6
3
E
0
2
9.
6
3
E
0
2
9.
7
1
E
0
2
G
O:
00
03
73
0
mRNA 3-UTR binding
mol
ecul
ar_f
unct
ion
apoptotic protease activator activity
mol
ecul
ar_f
unct
ion
calmodulin-dependent protein kinase
activity
mol
ecul
ar_f
unct
ion
G
O:
00
55
03
7
recycling endosome
cell
ular
AVL9,NISCH,SLC11A2,ATP11B,WASH4P,RAB8A,RAB10,SCAMP1,DEN
_co
ND6B
mpo
nent
1.63
558
376
6
G
O:
cellular response to cytokine stimulus
biol
ogic
1.23
024
G
O:
00
16
50
5
G
O:
00
04
68
3
RC3H1,SERBP1,PARN,CIRBP
2.25
112
714
2
NLRP1,BCL2L13,NOD1,CTSH
2.25
112
714
2
EEF2K,CAMK2D,PHKG2,PHKG1
2.25
112
714
2
HLA-DPB1,CNTF,NUP98,SMPD4,VRK2,IL15RA,LEF1,HLA-C,HLADQA1,XAF1,PTPN6,STAT2,NUP210,IL13RA1,CAMK2D,SHARPIN,TNF
9.
7
2
E
0
2
9.
7
2
E
0
2
9.
7
2
E
0
2
9.
7
5
E
0
2
9.
7
00
71
34
5
al_p RSF25,IFITM3,RPS6KA5,PAFAH1B1,IL18,NR1H3,RQCD1,KPNB1,LIFR,
roce DDX41,HLAss
F,PTPRC,NUP37,IL10RA,LEPR,CSF1R,IRF9,GAPDH,NUP85,EPOR,TN
FRSF14,PTGIS,STAT6,KPNA1,ZC3H15
G
O:
20
01
24
2
regulation of intrinsic apoptotic signaling
pathway
biol
ogic
al_p BCL2L11,DNM1L,SEPT4,BCLAF1
roce
ss
2.24
543
874
9
cellular response to nutrient
biol
ogic
al_p MDM2,CHMP1A,RRP8,USF1
roce
ss
2.24
543
874
9
renal tubule morphogenesis
biol
ogic
al_p PAX8,PKD2,MEF2A,PKD1
roce
ss
2.24
543
874
9
endochondral ossification
biol
ogic
al_p COL2A1,RUNX2,MEF2A,COL13A1
roce
ss
2.24
543
874
9
G
O:
00
31
67
0
G
O:
00
61
33
3
G
O:
00
01
95
8
038
4
6
E
0
2
9.
7
9
E
0
2
9.
7
9
E
0
2
9.
7
9
E
0
2
9.
7
9
E
0
2
G
O:
00
48
16
9
regulation of long-term neuronal synaptic
plasticity
biol
ogic
al_p BDNF,NPTN,NF1,RAB8A
roce
ss
2.24
543
874
9
replacement ossification
biol
ogic
al_p COL2A1,RUNX2,MEF2A,COL13A1
roce
ss
2.24
543
874
9
establishment of organelle localization
biol
ogic
SEPT5,SEC31A,SNAP23,NUMA1,RB1,BLOC1S5,PAFAH1B1,CDK5RAP
al_p
2,SUN2,TMED2,LRPPRC,SDAD1,CLASP1
roce
ss
1.48
427
307
1
G
O:
00
17
01
5
regulation of transforming growth factor
beta receptor signaling pathway
biol
ogic
SMAD7,GLG1,ZEB1,LTBP4,FLCN,USP15,SMAD4,TGFB1I1,ENG,TGFB
al_p
R3,PDPK1
roce
ss
1.54
373
914
G
O:
immunoglobulin mediated immune
response
biol
ogic
1.51
094
G
O:
00
36
07
5
G
O:
00
51
65
6
BCL6,PTPN6,C2,RNF8,RNF168,C1R,PTPRC,SWAP70,C3,C1S,ERCC1,
STAT6
9.
7
9
E
0
2
9.
7
9
E
0
2
9.
8
2
E
0
2
9.
8
7
E
0
2
9.
8
00
16
06
4
G
O:
00
00
78
4
G
O:
00
10
50
6
G
O:
00
30
03
6
G
O:
00
10
03
3
al_p
roce
ss
943
9
nuclear chromosome, telomeric region
cell
ular
_co OBFC1,ACD,SUN2,ERCC1
mpo
nent
2.23
893
244
4
regulation of autophagy
biol
ogic
al_p USP10,SUPT5H,NPC1,ZC3H12A,ATG4B,TBC1D14,WAC,NRBP2
roce
ss
1.68
407
906
2
actin cytoskeleton organization
biol
ogic
al_p
roce
ss
BCL6,ARPC4TTLL3,NISCH,PAM,CAPZB,SIPA1L1,MINK1,RHOF,ACTR3,VASP,PPM1
F,SSH2,LIMCH1,NF1,CAPN10,PAFAH1B1,ARPC2,CYTH2,DAAM1,PHP
T1,MEF2A,WASH4P,VILL,PAK1,NCK2,TRPM7,CSF1R,ACTR2,EZR,FH
OD1,FLNA,NOX4,PDGFRB,SDAD1,TLN1,TWF1,ATXN3,CORO7,PDPK1
,SSH1
1.23
037
739
7
response to organic substance
biol
ogic
al_p
roce
ss
ACADVL,EIF2B4,IGF1R,RAF1,NLRP1,F11R,BDNF,COL2A1,SUPT5H,H
LADPB1,CMPK2,MMS19,CNTF,EEF2K,VAPB,NUP98,SMPD4,SMAD7,HD
AC6,GLG1,ATP6V1D,VRK2,DERL2,IL15RA,LANCL2,H6PD,LEF1,PAX8,
HLA-C,XBP1,PAM,HLADQA1,XAF1,PTPN6,ACTR3,IGBP1,PRKACA,STAT2,ASNS,COL16A1,H
1.09
868
562
6
7
E
0
2
9.
9
1
E
0
2
1.
0
0
E
0
1
1.
0
1
E
0
1
1.
0
2
E
0
G
O:
00
46
91
4
transition metal ion binding
mol
ecul
ar_f
unct
ion
DGF,PPP5C,NPC1,ZC3H12A,NUP210,IL13RA1,CNP,CAMK2D,FGFR1,
ADCY4,PDE4D,PAF1,SHARPIN,IDI1,SEC31A,MDM2,RHBDD1,FKBP1A,
YY1,CREB1,NPTN,TNFRSF25,DDX58,PTPRK,SERPINH1,ZEB1,EIF4B,
CRIP1,NUB1,IFITM3,RPS6KA5,RAB31,CAPN10,RXRB,LMNA,LTBP4,G
NAI1,PAFAH1B1,EDEM2,IL18,CALCOCO2,TPP1,AACS,ANXA5,NR1H3,
GRB10,FLCN,NRP1,PTEN,FYN,IDH1,RUNX2,PHPT1,HERPUD1,RQCD
1,PXN,KPNB1,NCOR1,MEF2A,OXCT1,LIFR,FIBP,USP15,DDX41,HLAF,ABCA2,DENND4C,CSK,PTPRC,NUP37,IL10RA,PAK1,LEPROT,LEPR,
RAB10,RHEB,CTSH,GNB3,CSF1R,ATP6V0A1,SMAD4,TGFB1I1,DTYM
K,NR2C2,IRF9,ENG,ARNT,NOX4,GAPDH,ERCC1,PDIA5,NUP85,ITGA5
,PDGFRB,EPOR,TNFRSF14,YIF1A,TLN1,FGF14,GSK3A,NCOR2,IGF2,
PTGIS,ATXN3,AMFR,CRIPAK,LONP2,STAT6,ROBO2,NTRK1,SMAD9,D
USP6,TGFBR3,PDPK1,USF1,KPNA1,SSH1,FMOD,ZC3H15,PGRMC2
RSPRY1,LPP,DHX34,CRIP2,RAI1,SIRT2,UTRN,MYNN,ZNF131,LEPRE
1,RBM6,CPE,MARCH5,BCL6,ZNF783,ZFP91,HDAC6,EHMT1,ZNF496,T
YW1B,SYTL4,SUPT4H1,ZNF83,ADAMTS1,ZSCAN31,CPM,PAM,ADAM
8,RNF220,XAF1,PCGF6,MARCH6,PDLIM5,RNF24,LHX4,ZNF446,UPF1,
ZNF621,RC3H1,PDXK,HERC2,MIB2,PCGF1,ZNF721,ZNF397,JHDM1D,
ZNF710,DNPEP,USP20,GIT2,ZNF142,ZNF540,MAN2C1,MMP16,SF3A2
,TAB2,SHARPIN,DPF2,IDI1,RNF8,CYP2R1,MDM2,KCMF1,ZCCHC14,Z
NF595,YY1,DDX58,ZCCHC9,LIMCH1,ZEB1,CRIP1,PHF15,UNKL,ZNF3,
ALKBH3,ZNF837,RXRB,GALT,ZZEF1,RABGGTA,USP3,MZF1,ZFPM2,R
NF168,ZNF865,RNF217,CHMP1A,ACAP2,ZNF558,GALNT2,ADAM15,U
SP33,ZNF263,ZNF180,ZNF276,NR1H3,ZNF605,CHFR,ZNF410,PTGR2,
PXN,ADAMTS18,KPNB1,PPP1R10,ZMYM5,FECH,PIAS2,MYCBP2,DDX
41,RNF213,ZNF565,ZFAND2B,TRIM28,CP,RNF146,AGBL5,ZNF148,ZN
F76,OGFOD3,SP110,ZSWIM7,IKZF5,ZNF609,CHURC1,CHURC1FNTB,ZNF114,TGFB1I1,LIMD2,MTRR,ZNF44,ING4,ZNF687,NR2C2,CA
5B,GLI3,ZSCAN5A,ZNF692,PHF1,B3GAT3,DEF8,PHF12,ASAP1,ZNF55
4,PTGR1,CIZ1,HINFP,MAN2A2,DZIP1,GLIS3,DBF4,TRIM41,MFI2,ZNF5
18B,ZNF90,ZNF638,PHC3,DNAJC21,LONRF3,ZNF383,SETD2,PTGIS,A
MFR,PHF21A,ZNF138,ZNF705A,SHPRH,HBB,LIMS2,ZBTB16,ZDHHC8,
1
1.09
090
766
4
1.
0
2
E
0
1
BAZ2A,SIRT3,PLOD2,PHF19,LMCD1,ZC3H14,MMP25,UBR5,PHC2,ZC3
H15,GATA2
G
O:
00
44
72
3
single-organism carbohydrate metabolic
process
biol
ogic
al_p
roce
ss
GK5,SIRT2,ST3GAL1,SPATA20,H6PD,NISCH,MPDU1,PRKACA,NPC1,
GALK2,MAN2C1,SEC31A,MCFD2,ALG6,ST3GAL4,GCNT2,GALT,ISYN
A1,EDEM2,GALNT2,GRB10,NCOR1,SMEK1,MAN1A2,ST6GALNAC5,P
HKG2,FUT4,C1QTNF3,SLC23A2,MGAT5,B4GALT4,ARNT,EXT1,GAPD
H,GAA,B3GAT3,MAN2A2,MAN1B1,ENO4,CANX,GSK3A,PDIA3,IGF2,P
GM2,CTBS,PHKG1,LMF1,SIRT3,USF1,ALG9,RBKS
1.19
704
574
4
G
O:
00
19
19
9
transmembrane receptor protein kinase
activity
mol
ecul
ar_f
unct
ion
IGF1R,FGFR1,FKBP1A,LTBP4,NRP1,FBXW7,NCK2,CSF1R,ENG,PDGF
RB,NTRK1,TGFBR3
1.50
075
142
8
G
O:
00
02
47
9
antigen processing and presentation of
exogenous peptide antigen via MHC class I,
TAP-dependent
biol
ogic
al_p PSMB10,HLA-C,PSMB9,ITGB5,HLA-F,PSMC6,PSMC4,PDIA3,PSMA1
roce
ss
1.61
671
589
9
G
O:
00
01
01
2
RNA polymerase II regulatory region DNA
binding
mol
ecul
ar_f
unct
ion
LEF1,PAX8,CREB1,MEF2A,TCF4,SMARCA4,NCOR2,ATXN3,STAT6,C
C2D1A,GATA2
1.53
169
475
6
G
O:
determination of heart left/right asymmetry
biol
ogic
NPHP3,TBX2,PKD2,MEF2A,TMED2,ENG,C2CD3
1.74
645
1.
0
2
E
0
1
1.
0
2
E
0
1
1.
0
3
E
0
1
1.
0
3
E
0
1
1.
0
00
61
37
1
G
O:
00
16
19
7
G
O:
00
09
30
6
G
O:
00
43
06
5
G
O:
00
43
08
7
al_p
roce
ss
236
endosomal transport
biol
ogic
HGS,RAB35,VAMP7,VTI1A,STX16,BLOC1S5,GCC2,SNX17,WASH4P,R
al_p
AB10,ERC1,FLNA,STAM2,VPS51,SNX27,TSG101
roce
ss
1.40
890
274
4
protein secretion
biol
ogic CADM1,BTN3A1,NLRP1,SYTL4,PAM,ADAM8,DNM1L,DISP1,LCP2,RHB
al_p DF1,PAFAH1B1,NR1H3,NECAB3,CSF1R,C1QTNF3,CANX,RHBDF2,LM
roce F1
ss
1.37
788
286
9
positive regulation of apoptotic process
biol
ogic
al_p
roce
ss
NLRP1,PPP1R13B,BCL6,HDAC6,CASP4,LEF1,BCL2L13,BCL2L11,ADA
M8,NOD1,SHISA5,SEPT4,BCLAF1,STK4,DPF2,TNFRSF25,DFNA5,NF1
,COL18A1,CAPN10,CASP2,IL18,MTCH1,FLCN,SAP30BP,PTEN,ALDH1
A3,MEF2A,PTPRC,ING4,NOX4,TEX261,ARHGEF7,DIABLO,PDIA3,PTG
IS,DUSP6,ZBTB16,STK24
1.23
052
146
9
regulation of GTPase activity
biol
ogic
al_p
roce
ss
RAB3GAP2,RALGAPA2,BCL6,ARHGEF12,STARD13,RANBP1,SIPA1L1
,TBC1D2B,TBC1D10B,TBC1D14,GIT2,FAM13A,SNX13,NF1,PAFAH1B1
,ACAP2,RGS3,ARHGAP9,IQGAP1,SRGAP2,TBCD,ARHGAP29,SGSM3,
SEMA4D,TBC1D22A,TMED2,ARHGEF7,ASAP1,RGS2,BNIP2,NTRK1,R
APGEF6
1.26
059
719
2
3
E
0
1
1.
0
3
E
0
1
1.
0
3
E
0
1
1.
0
4
E
0
1
1.
0
4
E
0
1
G
O:
00
19
21
3
deacetylase activity
mol
ecul
ar_f
unct
ion
spindle organization
biol
ogic
STARD9,RANBP1,INO80,NTMT1,PLK2,NCOR1,FLNA,SUN2,HAUS5,SE
al_p
NP6
roce
ss
1.56
658
517
4
regulation of immunoglobulin mediated
immune response
biol
ogic
al_p BCL6,PTPN6,PTPRC,C3,STAT6
roce
ss
1.98
126
948
4
G
O:
00
51
78
5
positive regulation of nuclear division
biol
ogic
al_p PLK1,RB1,PTEN,PDGFRB,IGF2
roce
ss
1.98
126
948
4
G
O:
sister chromatid cohesion
biol
ogic
1.98
126
G
O:
00
07
05
1
G
O:
00
02
88
9
SIRT2,HDAC6,NCOR1,MAPK8,SIRT7,CES2
NIPBL,RB1,FBXW7,STAG2,MAU2
1.84
183
129
8
1.
0
4
E
0
1
1.
0
4
E
0
1
1.
0
4
E
0
1
1.
0
4
E
0
1
1.
0
00
07
06
2
G
O:
00
46
47
1
G
O:
00
07
04
0
G
O:
00
14
89
6
G
O:
00
45
84
0
al_p
roce
ss
948
4
phosphatidylglycerol metabolic process
biol
ogic
al_p TAZ,PLD1,PGS1,PLD6,LPCAT1
roce
ss
1.98
126
948
4
lysosome organization
biol
ogic
al_p CLN8,HPS4,TPP1,HEXA,GAA
roce
ss
1.98
126
948
4
muscle hypertrophy
biol
ogic
al_p CAMK2D,MEF2A,RGS2,GSK3A,LMCD1
roce
ss
1.98
126
948
4
positive regulation of mitosis
biol
ogic
al_p PLK1,RB1,PTEN,PDGFRB,IGF2
roce
ss
1.98
126
948
4
4
E
0
1
1.
0
4
E
0
1
1.
0
4
E
0
1
1.
0
4
E
0
1
1.
0
4
E
0
1
G
O:
00
42
99
2
1.98
126
948
4
1.
0
4
E
0
1
1.12
271
937
4
1.
0
4
E
0
1
negative regulation of transcription factor
import into nucleus
biol
ogic
al_p NF1,PKD2,C1QTNF3,MDFI,PKD1
roce
ss
positive regulation of molecular function
CRBN,RAB3GAP2,ACADVL,PSMB10,IGF1R,RALGAPA2,RAF1,NLRP1,
ZFP91,VAPB,ARHGEF12,PSMB9,BCL2L13,BCL2L11,STARD13,XBP1,A
DAM8,DNAJC10,RANBP1,SIPA1L1,KRIT1,NOD1,PRKACA,ANAPC4,PL
K1,ASNS,TBC1D2B,HDGF,TBC1D10B,SLC11A2,TBC1D14,GIT2,STK4,
biol FGFR1,MMP16,ADCY4,TAB2,SGK1,SEC31A,FKBP1A,PRKCH,PPM1F,
ogic FAM13A,CREB1,DDX58,SNX13,NF1,RPS6KA5,PKD2,LMNA,MAPK8IP3
al_p ,TP53BP1,MTCH1,TPP1,ACAP2,RGS3,NR1H3,NRP1,ARHGAP9,PTEN,I
roce QGAP1,FBXW7,HERPUD1,IKBKB,RQCD1,PXN,SRGAP2,MEF2A,SSBP
ss
1,MAPK8,CSK,PTPRC,PSMC6,TBCD,PSMC4,ARHGAP29,SGSM3,UBA
2,PAK1,CTSH,ACD,SEMA4D,CSF1R,ERC1,TBC1D22A,CDC14B,NOX4,
STK36,ARHGEF7,PDIA5,ASAP1,MDFI,RGS2,PDGFRB,CARD14,DIABL
O,DBF4,SMARCA4,YIF1A,TLN1,GSK3A,IGF2,PSMA1,BNIP2,NTRK1,TN
FRSF10B,LMF1,TGFBR3,PKD1,PDPK1
G
O:
00
48
01
1
nerve growth factor receptor signaling
pathway
biol
ogic RAF1,MCF2L,ARHGEF12,BCL2L11,PRKACA,ADCY4,MDM2,CREB1,PL
al_p EKHG5,RPS6KA5,CASP2,PTEN,IKBKB,MEF2A,MAPK8,MAPK12,RASG
roce RF2,ARHGEF7,GSK3A,NTRK1,DUSP6,PDPK1
ss
1.32
913
863
2
G
O:
00
ventricular cardiac muscle tissue
development
biol
ogic
al_p
1.83
717
715
G
O:
00
44
09
3
SMAD7,FKBP1A,ZFPM2,GAA,TGFBR3,FOXC1
1.
0
5
E
0
1
1.
0
5
03
22
9
G
O:
00
07
03
4
G
O:
00
45
45
3
G
O:
00
51
22
5
G
O:
00
06
40
2
roce
ss
8
vacuolar transport
biol
ogic
al_p HGS,NPC1,VAMP7,GCC2,HGSNAT,SNX27
roce
ss
1.83
717
715
8
bone resorption
biol
ogic
al_p ADAM8,NF1,TPP1,CSK,CSF1R,NOX4
roce
ss
1.83
717
715
8
spindle assembly
biol
ogic
al_p STARD9,INO80,NCOR1,FLNA,HAUS5,SENP6
roce
ss
1.83
717
715
8
mRNA catabolic process
biol
ogic
XRN1,RNH1,UPF3A,UPF1,RC3H1,PAIP1,RPL27,EIF4B,RPL9,DDX6,PA
al_p
N2,RPL24,RPL37A,RQCD1,PARN,RPL4,NCBP2,RPLP0,PABPC1
roce
ss
1.36
159
583
7
E
0
1
1.
0
5
E
0
1
1.
0
5
E
0
1
1.
0
5
E
0
1
1.
0
5
E
0
1
G
O:
00
00
97
5
G
O:
00
01
06
7
G
O:
00
34
63
7
G
O:
00
45
27
5
G
O:
00
05
regulatory region DNA binding
mol
ecul
ar_f
unct
ion
SMAD7,LEF1,PAX8,EMX2,GABPB1,TBX18,TBP,YY1,CREB1,ZEB1,RX
RB,RB1,MZF1,NR1H3,RUNX2,NCOR1,MEF2A,CDK5RAP2,ZNF148,HN
RNPL,TCF4,SMAD4,IRF9,TCF12,HINFP,RUNX1,SMARCA4,NCOR2,AT
XN3,STAT6,TFAM,FOXC1,CC2D1A,GATA2
1.24
790
743
7
regulatory region nucleic acid binding
mol
ecul
ar_f
unct
ion
SMAD7,LEF1,PAX8,EMX2,GABPB1,TBX18,TBP,YY1,CREB1,ZEB1,RX
RB,RB1,MZF1,NR1H3,RUNX2,NCOR1,MEF2A,CDK5RAP2,ZNF148,HN
RNPL,TCF4,SMAD4,IRF9,TCF12,HINFP,RUNX1,SMARCA4,NCOR2,AT
XN3,STAT6,TFAM,FOXC1,CC2D1A,GATA2
1.24
790
743
7
cellular carbohydrate biosynthetic process
biol
ogic
al_p ISYNA1,GRB10,PHKG2,EXT1,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.65
817
015
3
respiratory chain complex III
cell
ular
_co BCS1L,UQCRH
mpo
nent
3.49
833
194
3
mitochondrial respiratory chain complex III
cell
ular
BCS1L,UQCRH
_co
mpo
3.49
833
194
3
1.
0
6
E
0
1
1.
0
6
E
0
1
1.
0
7
E
0
1
1.
0
7
E
0
1
1.
0
7
E
75
0
G
O:
00
31
46
4
G
O:
00
51
13
0
G
O:
00
51
11
7
G
O:
00
05
21
8
nent
Cul4A-RING ubiquitin ligase complex
cell
ular
_co CRBN,CUL4A
mpo
nent
positive regulation of cellular component
organization
biol
ogic
al_p
roce
ss
ATPase binding
mol
ecul
ar_f
unct
ion
intracellular ligand-gated calcium channel
activity
mol
ecul
ar_f
unct
ion
3.49
833
194
3
BDNF,MARCH5,HDAC6,ARPC4TTLL3,LEF1,PAX8,BCL2L11,RANBP1,ACTR3,PLK1,DNM1L,BCLAF1,F
GFR1,CAPRIN1,PPM1F,NPTN,RPS6KA5,NIPBL,RB1,PAFAH1B1,ARPC
2,BICD1,PTEN,FYN,NCOR1,WASH4P,WDR61,PAK1,NCK2,SEMA4D,A
CTR2,C3,SMAD4,TGFB1I1,FHOD1,NOX4,PHF1,PTPRD,PDGFRB,NLG
N2,IGF2,ROBO2,NTRK1,PHF19,PDPK1,GATA2
1.20
338
076
6
UBXN1,DNAJC10,PKD2,ATP6V0A1
2.16
108
205
6
CAMK2D,TPCN2,FKBP1A,PKD2
2.16
108
205
6
0
1
1.
0
7
E
0
1
1.
0
9
E
0
1
1.
0
9
E
0
1
1.
0
9
E
0
1
G
O:
00
08
27
7
regulation of G-protein coupled receptor
protein signaling pathway
biol
ogic
ARHGEF12,USP20,GIT2,SNX13,USP33,BICD1,RGS3,C3,RGS2,ADRBK
al_p
2,GSK3A,SNX14
roce
ss
1.48
322
559
6
positive regulation of transferase activity
biol
ogic
al_p
roce
ss
ACADVL,IGF1R,RAF1,ZFP91,VAPB,XBP1,ADAM8,NOD1,PRKACA,ASN
S,HDGF,STK4,FGFR1,ADCY4,TAB2,SEC31A,PKD2,LMNA,MAPK8IP3,T
PP1,IQGAP1,FBXW7,HERPUD1,PXN,CSK,PTPRC,PAK1,ACD,CSF1R,
NOX4,PDIA5,MDFI,PDGFRB,CARD14,YIF1A,TLN1,GSK3A,IGF2,NTRK
1,TNFRSF10B,PKD1,PDPK1
1.21
427
159
8
cell adhesion molecule binding
mol
ecul
ar_f
unct
ion
CADM1,CPE,ADAM8,NPTN,EZR,PTPRD,NLGN2
1.71
904
254
4
G
O:
00
18
20
9
peptidyl-serine modification
biol
ogic
RAF1,SMAD7,UHMK1,PRKACA,PLK1,CAMK2D,STK4,PPM1F,RPS6KA
al_p
5,GALNT2,NTMT1,MAPK8,PAK1,MAPK12,PKD1
roce
ss
1.41
321
319
9
G
O:
00
43
positive regulation of I-kappaB kinase/NFkappaB cascade
biol
ogic NOD1,PPP5C,SHISA5,MIB2,TAB2,SHARPIN,FKBP1A,PLEKHG5,PLK2,I
al_p KBKB,LTBR,APOL3,FLNA,TNFRSF10B,CC2D1A
roce
1.41
321
319
9
G
O:
00
51
34
7
G
O:
00
50
83
9
1.
0
9
E
0
1
1.
0
9
E
0
1
1.
1
0
E
0
1
1.
1
0
E
0
1
1.
1
0
E
12
3
G
O:
00
31
12
3
G
O:
00
00
23
6
G
O:
00
34
97
9
G
O:
00
60
99
8
ss
RNA 3-end processing
biol
ogic
SYMPK,PAIP1,PAF1,EIF4B,PAN2,CSTF1,RQCD1,PARN,NCBP2,PABP
al_p
C1,PABPN1
roce
ss
1.51
223
425
9
mitotic prometaphase
biol
ogic
NUP98,APITD1,PLK1,PAFAH1B1,DSN1,NUP37,STAG2,CENPT,NUP85,
al_p
CLASP1
roce
ss
1.54
857
844
8
NAD-dependent protein deacetylase activity
mol
ecul
ar_f
unct
ion
2.53
251
803
4
regulation of dendritic spine development
biol
ogic
al_p SIPA1L1,PDLIM5,CAPRIN1,PTEN
roce
ss
SIRT2,HDAC6,SIRT7
2.15
562
119
9
0
1
1.
1
0
E
0
1
1.
1
0
E
0
1
1.
1
0
E
0
1
1.
1
0
E
0
1
G
O:
00
90
31
1
G
O:
00
01
93
7
G
O:
00
05
98
0
G
O:
00
06
37
8
G
O:
00
06
regulation of protein deacetylation
biol
ogic
al_p NIPBL,NCOR1,MAPK8,SPRED1
roce
ss
2.15
562
119
9
negative regulation of endothelial cell
proliferation
biol
ogic
al_p KRIT1,NF1,ATP5A1,ENG
roce
ss
2.15
562
119
9
glycogen catabolic process
biol
ogic
al_p PHKG2,GAA,PGM2,PHKG1
roce
ss
2.15
562
119
9
mRNA polyadenylation
biol
ogic
al_p SYMPK,PAF1,CSTF1,PABPC1
roce
ss
2.15
562
119
9
nuclear envelope organization
biol
ogic
LMNA,PAFAH1B1,SUN2
al_p
roce
2.52
611
859
3
1.
1
0
E
0
1
1.
1
0
E
0
1
1.
1
0
E
0
1
1.
1
0
E
0
1
1.
1
1
E
99
8
G
O:
00
31
06
2
G
O:
00
16
25
4
G
O:
00
06
10
3
G
O:
00
32
00
8
ss
positive regulation of histone methylation
biol
ogic
al_p WDR61,PHF1,PHF19
roce
ss
2.52
611
859
3
preassembly of GPI anchor in ER
membrane
biol
ogic
al_p PIGG,PIGN,PIGO
roce
ss
2.52
611
859
3
2-oxoglutarate metabolic process
biol
ogic
al_p IDH1,IDH3B,D2HGDH
roce
ss
2.52
611
859
3
positive regulation of TOR signaling
cascade
biol
ogic
al_p FLCN,RHEB,GOLPH3
roce
ss
2.52
611
859
3
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
G
O:
00
02
82
3
G
O:
00
30
94
9
G
O:
00
40
00
1
G
O:
00
10
63
4
G
O:
00
46
negative regulation of adaptive immune
response based on somatic recombination
of immune receptors built from
immunoglobulin superfamily domains
biol
ogic
al_p PTPN6,RC3H1,PTPRC
roce
ss
2.52
611
859
3
positive regulation of vascular endothelial
growth factor receptor signaling pathway
biol
ogic
al_p GRB10,ARNT,ITGA5
roce
ss
2.52
611
859
3
establishment of mitotic spindle localization
biol
ogic
al_p NUMA1,PAFAH1B1,CDK5RAP2
roce
ss
2.52
611
859
3
positive regulation of epithelial cell migration
biol
ogic
al_p HDAC6,PPM1F,CTSH
roce
ss
2.52
611
859
3
phospholipid dephosphorylation
biol
ogic
EPHX2,PTEN,PPAP2A
al_p
roce
2.52
611
859
3
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
83
9
G
O:
00
72
07
4
G
O:
00
45
07
0
G
O:
00
32
33
2
G
O:
00
43
58
6
ss
kidney mesenchyme development
biol
ogic
al_p PKD2,SMAD4,PDGFRB
roce
ss
2.52
611
859
3
positive regulation of viral genome
replication
biol
ogic
al_p VAPB,RAD23A,SRPK1
roce
ss
2.52
611
859
3
positive regulation of chondrocyte
differentiation
biol
ogic
al_p RUNX2,GLI3,ZBTB16
roce
ss
2.52
611
859
3
tongue development
biol
ogic
al_p LEF1,GLI3,GAA
roce
ss
2.52
611
859
3
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
G
O:
00
02
46
7
G
O:
00
07
58
5
G
O:
00
32
87
0
G
O:
00
00
95
6
G
O:
00
01
germinal center formation
biol
ogic
al_p BCL6,RC3H1,MEF2A
roce
ss
2.52
611
859
3
respiratory gaseous exchange
biol
ogic
al_p GLS,JAG2,MAPK8IP3,MAN1A2,PBX3,GAA,NLGN2
roce
ss
1.71
469
868
1
cellular response to hormone stimulus
biol
ogic
al_p
roce
ss
1.21
924
276
nuclear-transcribed mRNA catabolic
process
biol
ogic
XRN1,UPF3A,UPF1,RC3H1,PAIP1,RPL27,EIF4B,RPL9,DDX6,PAN2,RP
al_p
L24,RPL37A,RQCD1,PARN,RPL4,NCBP2,RPLP0,PABPC1
roce
ss
1.36
240
103
9
placenta development
biol
ogic PLCD1,LEF1,LHX4,STK4,PKD2,RXRB,TRIM28,TMED2,ARNT,MDFI,EP
al_p OR,SETD2,PKD1,GATA2
roce
1.42
891
556
7
IGF1R,RAF1,EEF2K,ATP6V1D,LANCL2,LEF1,PAX8,PTPN6,PRKACA,A
SNS,NPC1,FGFR1,ADCY4,MDM2,EIF4B,RAB31,CAPN10,RXRB,IL18,A
ACS,NR1H3,GRB10,FYN,PXN,DENND4C,CSK,PAK1,LEPROT,RAB10,
RHEB,CTSH,GNB3,ATP6V0A1,NR2C2,GSK3A,IGF2,ROBO2,PDPK1,US
F1,PGRMC2
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
1
E
0
1
1.
1
2
E
0
1
1.
1
2
E
89
0
G
O:
00
01
66
6
G
O:
00
00
77
5
G
O:
00
33
12
4
G
O:
00
33
67
4
ss
response to hypoxia
biol
ogic RAF1,BDNF,DPP4,PAM,ADAM8,SLC11A2,MDM2,NF1,ADSL,LMNA,IL1
al_p 8,PAK1,SMAD4,ENG,SCFD1,ARNT,NOX4,PTGIS,SMAD9,TGFBR3,PLO
roce D2,USF1
ss
1.31
732
406
6
chromosome, centromeric region
cell
ular
CBX5,NUP98,DYNC1I1,APITD1,PLK1,TP53BP1,PAFAH1B1,DSN1,NUP
_co
37,STAG2,CENPT,NUP85,NCAPD3,SEPT2,CLASP1
mpo
nent
1.40
872
427
2
regulation of GTP catabolic process
biol
ogic
al_p
roce
ss
RAB3GAP2,RALGAPA2,BCL6,ARHGEF12,STARD13,RANBP1,SIPA1L1
,TBC1D2B,TBC1D10B,TBC1D14,GIT2,FAM13A,SNX13,NF1,PAFAH1B1
,ACAP2,RGS3,ARHGAP9,IQGAP1,SRGAP2,TBCD,ARHGAP29,SGSM3,
SEMA4D,TBC1D22A,TMED2,ARHGEF7,ASAP1,RGS2,BNIP2,NTRK1,R
APGEF6
1.24
963
547
8
positive regulation of kinase activity
biol
ogic
al_p
roce
ss
ACADVL,IGF1R,RAF1,ZFP91,VAPB,XBP1,ADAM8,NOD1,PRKACA,ASN
S,HDGF,STK4,FGFR1,ADCY4,TAB2,SEC31A,PKD2,LMNA,MAPK8IP3,T
PP1,IQGAP1,FBXW7,HERPUD1,PXN,CSK,PTPRC,PAK1,CSF1R,NOX4,
PDIA5,MDFI,PDGFRB,CARD14,YIF1A,TLN1,GSK3A,IGF2,NTRK1,TNFR
SF10B,PKD1,PDPK1
1.21
401
743
3
0
1
1.
1
2
E
0
1
1.
1
2
E
0
1
1.
1
3
E
0
1
1.
1
3
E
0
1
G
O:
00
16
12
5
G
O:
00
71
36
3
G
O:
00
04
53
5
G
O:
00
70
53
0
G
O:
00
04
sterol metabolic process
biol
ogic
ACADVL,EPHX2,FDPS,FDXR,NPC1,CLN8,IDI1,STARD3,SNX17,FECH,
al_p
LEPR,EBPL,LMF1
roce
ss
1.44
747
291
3
cellular response to growth factor stimulus
biol
ogic
al_p
roce
ss
RAF1,F11R,COL2A1,SMAD7,GLG1,PRKACA,FGFR1,ADCY4,MDM2,FK
BP1A,CREB1,NPTN,PTPRK,ZEB1,LTBP4,GRB10,FLCN,NRP1,PTEN,F
YN,RUNX2,NCOR1,FIBP,USP15,SMAD4,TGFB1I1,DTYMK,ENG,ARNT,
NOX4,ITGA5,PDGFRB,FGF14,GSK3A,NCOR2,SMAD9,DUSP6,TGFBR3
,PDPK1,FMOD
1.21
649
051
9
poly(A)-specific ribonuclease activity
mol
ecul
ar_f
unct
ion
PAN2,PARN
3.37
669
071
2
K63-linked polyubiquitin binding
mol
ecul
ar_f
unct
ion
TAB2,RNF168
3.37
669
071
2
phosphorylase kinase activity
mol
ecul
ar_f
unct
PHKG2,PHKG1
3.37
669
071
2
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
68
9
G
O:
00
34
45
0
G
O:
00
05
02
1
G
O:
00
50
70
0
G
O:
00
02
16
1
ion
ubiquitin-ubiquitin ligase activity
mol
ecul
ar_f
unct
ion
vascular endothelial growth factor-activated
receptor activity
mol
ecul
ar_f
unct
ion
CARD domain binding
mol
ecul
ar_f
unct
ion
aminoacyl-tRNA editing activity
mol
ecul
ar_f
unct
ion
PPIL2,UBR5
3.37
669
071
2
NRP1,PDGFRB
3.37
669
071
2
NOD1,CARD14
3.37
669
071
2
VARS,LARS
3.37
669
071
2
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
G
O:
00
14
82
3
G
O:
00
02
71
2
G
O:
00
16
92
5
G
O:
00
02
92
0
G
O:
00
31
response to activity
biol
ogic
al_p ZEB1,ADSL,TENC1,OXCT1,NTRK1
roce
ss
1.92
466
178
5
regulation of B cell mediated immunity
biol
ogic
al_p BCL6,PTPN6,PTPRC,C3,STAT6
roce
ss
1.92
466
178
5
protein sumoylation
biol
ogic
al_p PIAS2,TRIM28,UBA2,ARNT,SENP6
roce
ss
1.92
466
178
5
regulation of humoral immune response
biol
ogic
al_p PTPN6,C2,CFB,PTPRC,C3
roce
ss
1.92
466
178
5
exocrine pancreas development
biol
ogic
IGF1R,XBP1
al_p
roce
3.36
815
812
3
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
01
7
G
O:
00
48
08
7
G
O:
00
07
17
2
G
O:
00
45
62
3
G
O:
00
72
17
3
ss
positive regulation of developmental
pigmentation
biol
ogic
al_p HPS4,BLOC1S5
roce
ss
3.36
815
812
3
signal complex assembly
biol
ogic
al_p PXN,NCK2
roce
ss
3.36
815
812
3
negative regulation of T-helper cell
differentiation
biol
ogic
al_p BCL6,RC3H1
roce
ss
3.36
815
812
3
metanephric tubule morphogenesis
biol
ogic
al_p PAX8,PKD1
roce
ss
3.36
815
812
3
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
G
O:
00
43
98
3
G
O:
00
46
59
9
G
O:
00
31
65
9
G
O:
00
45
21
7
G
O:
00
06
histone H4-K12 acetylation
biol
ogic
al_p PHF15,ING4
roce
ss
3.36
815
812
3
regulation of centriole replication
biol
ogic
al_p PLK2,CDK5RAP2
roce
ss
3.36
815
812
3
positive regulation of cyclin-dependent
protein kinase activity involved in G1/S
biol
ogic
al_p PKD2,PKD1
roce
ss
3.36
815
812
3
cell-cell junction maintenance
biol
ogic
al_p CSF1R,NLGN2
roce
ss
3.36
815
812
3
arginine catabolic process
biol
ogic
DDAH1,DDAH2
al_p
roce
3.36
815
812
3
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
52
7
G
O:
00
35
51
8
G
O:
00
71
16
8
G
O:
00
46
66
6
G
O:
20
01
23
9
ss
histone H2A monoubiquitination
biol
ogic
al_p PCGF1,RNF168
roce
ss
3.36
815
812
3
protein localization to chromatin
biol
ogic
al_p PLK1,RB1
roce
ss
3.36
815
812
3
retinal cell programmed cell death
biol
ogic
al_p BDNF,CNTF
roce
ss
3.36
815
812
3
regulation of extrinsic apoptotic signaling
pathway in absence of ligand
biol
ogic
al_p FYN,UNC5B
roce
ss
3.36
815
812
3
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
G
O:
00
30
85
4
G
O:
00
14
85
0
G
O:
00
60
97
7
G
O:
20
00
81
0
G
O:
00
16
positive regulation of granulocyte
differentiation
biol
ogic
al_p LEF1,RUNX1
roce
ss
3.36
815
812
3
response to muscle activity
biol
ogic
al_p ADSL,TENC1
roce
ss
3.36
815
812
3
coronary vasculature morphogenesis
biol
ogic
al_p PDGFRB,SETD2
roce
ss
3.36
815
812
3
regulation of tight junction assembly
biol
ogic
al_p PRKACA,PRKCH
roce
ss
3.36
815
812
3
rRNA catabolic process
biol
ogic
XRN1,DIS3L
al_p
roce
3.36
815
812
3
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
07
5
G
O:
00
48
06
9
G
O:
00
45
71
9
G
O:
00
42
49
2
G
O:
00
07
40
6
ss
eye pigmentation
biol
ogic
al_p LEF1,HPS4
roce
ss
3.36
815
812
3
negative regulation of glycogen biosynthetic
process
biol
ogic
al_p GRB10,GSK3A
roce
ss
3.36
815
812
3
gamma-delta T cell differentiation
biol
ogic
al_p JAG2,PTPRC
roce
ss
3.36
815
812
3
negative regulation of neuroblast
proliferation
biol
ogic
al_p BDNF,NF1
roce
ss
3.36
815
812
3
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
G
O:
00
32
78
5
G
O:
00
61
02
8
G
O:
00
97
19
2
G
O:
20
00
57
3
G
O:
00
72
negative regulation of DNA-dependent
transcription, elongation
biol
ogic
al_p SUPT5H,SUPT4H1
roce
ss
3.36
815
812
3
establishment of endothelial barrier
biol
ogic
al_p PDE4D,ENG
roce
ss
3.36
815
812
3
extrinsic apoptotic signaling pathway in
absence of ligand
biol
ogic
al_p FYN,UNC5B
roce
ss
3.36
815
812
3
positive regulation of DNA biosynthetic
process
biol
ogic
al_p NOX4,PDGFRB
roce
ss
3.36
815
812
3
metanephric nephron tubule morphogenesis
biol
ogic
PAX8,PKD1
al_p
roce
3.36
815
812
3
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
28
2
G
O:
00
72
10
2
G
O:
00
46
88
6
G
O:
00
43
37
1
G
O:
00
38
03
4
ss
glomerulus morphogenesis
biol
ogic
al_p MEF2A,PDGFRB
roce
ss
3.36
815
812
3
positive regulation of hormone biosynthetic
process
biol
ogic
al_p IGF1R,ARNT
roce
ss
3.36
815
812
3
negative regulation of CD4-positive, alphabeta T cell differentiation
biol
ogic
al_p BCL6,RC3H1
roce
ss
3.36
815
812
3
signal transduction in absence of ligand
biol
ogic
al_p FYN,UNC5B
roce
ss
3.36
815
812
3
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
4
E
0
1
G
O:
00
01
78
7
G
O:
00
08
23
8
G
O:
00
19
72
4
G
O:
00
70
84
8
G
O:
00
30
natural killer cell proliferation
biol
ogic
al_p PTPN22,IL18
roce
ss
3.36
815
812
3
exopeptidase activity
mol
ecul
ar_f
unct
ion
CPE,DPP4,CPM,SCRN3,DNPEP,TPP1,FAP,AGBL5,CTSH,ATXN3,DPP
7
1.50
075
142
8
B cell mediated immunity
biol
ogic
BCL6,PTPN6,C2,RNF8,RNF168,C1R,PTPRC,SWAP70,C3,C1S,ERCC1,
al_p
STAT6
roce
ss
1.46
974
172
7
response to growth factor stimulus
biol
ogic
al_p
roce
ss
1.21
135
511
5
coated vesicle
cell
CADM1,SEPT5,BDNF,HLA-DPB1,SYTL4,HLA-C,HLAular
DQA1,RAB35,TNK2,SEC31A,MCFD2,SYTL2,EPN2,CLTCL1,HLA_co
F,CLTB,AAK1,GOPC,TMED3,TMED2,MYO1E,CTTNBP2,SEC31B
mpo
RAF1,F11R,COL2A1,SMAD7,HDAC6,GLG1,PRKACA,FGFR1,ADCY4,M
DM2,FKBP1A,CREB1,NPTN,PTPRK,ZEB1,LTBP4,GRB10,FLCN,NRP1,
PTEN,FYN,RUNX2,NCOR1,FIBP,USP15,SMAD4,TGFB1I1,DTYMK,ENG
,ARNT,NOX4,ITGA5,PDGFRB,FGF14,GSK3A,NCOR2,SMAD9,DUSP6,T
GFBR3,PDPK1,FMOD
1.30
302
242
4
1.
1
4
E
0
1
1.
1
4
E
0
1
1.
1
5
E
0
1
1.
1
6
E
0
1
1.
1
6
E
13
5
G
O:
00
16
45
8
G
O:
00
10
64
7
G
O:
00
35
86
9
G
O:
00
00
30
7
nent
gene silencing
biol
ogic
TNRC6A,SIRT2,CELF1,CHMP1A,PIWIL4,NCBP2,SMARCA4,BAZ2A,RR
al_p
P8,PABPC1
roce
ss
positive regulation of cell communication
IGF1R,RAF1,SUPT5H,CNTF,HDAC6,LANCL2,BCL2L11,RBPMS,XBP1,
ADAM8,MINK1,PTPN6,CSNK2A1,NOD1,DNM1L,PPP5C,SHISA5,SEPT4
biol ,MIB2,BCLAF1,WAC,FGFR1,DISP1,TAB2,SHARPIN,FKBP1A,PRKCH,N
ogic PTN,PLEKHG5,PKD2,MAPK8IP3,PAFAH1B1,NR1H3,GRB10,PLK2,FLC
al_p N,PTEN,FBXW7,IKBKB,PXN,LTBR,MAPK8,SH3BP2,CSK,PTPRC,RNF1
roce 46,AAK1,PAK1,EVC,RHEB,SEMA4D,CSF1R,C3,SMAD4,C1QTNF3,TGF
ss
B1I1,GOLPH3,APOL3,FLNA,ENG,ARNT,NOX4,STK36,MDFI,ITGA5,PD
GFRB,GSK3A,ANKRD6,NLGN2,IGF2,PTGIS,CSNK1E,BNIP2,NTRK1,S
PRED1,TNFRSF10B,TGFBR3,LMCD1,UBR5,CC2D1A
ciliary transition zone
cell
ular
_co TCTN1,CC2D2A,TMEM237
mpo
nent
2.46
941
078
3
cyclin-dependent protein kinase
holoenzyme complex
cell
ular
_co CDK14,CDK13,CDK6
mpo
nent
2.46
941
078
3
1.53
098
096
5
1.14
054
031
7
0
1
1.
1
6
E
0
1
1.
1
7
E
0
1
1.
1
7
E
0
1
1.
1
7
E
0
1
G
O:
00
42
61
3
MHC class II protein complex
cell
ular
_co HLA-DPB1,HLA-DQA1,HLA-DMB
mpo
nent
2.46
941
078
3
methylation
biol
ogic SHMT2,EED,AMT,EHMT1,PRMT10,METTL3,PRMT5,NTMT1,USP7,PLD
al_p 6,SETD8,N6AMT1,WDR61,WDR4,PIWIL4,PHF1,TGS1,SMARCA4,THU
roce MPD2,SETD2,FTSJ3,BAZ2A,RRP8,PHF19,HEMK1
ss
1.28
555
653
6
regulation of anatomical structure
morphogenesis
biol
ogic
al_p
roce
ss
FZD6,NPHP3,BDNF,MARCH5,TBX2,CNTF,SMAD7,RNH1,LEF1,PAX8,C
APZB,PRPF40A,SIPA1L1,KRIT1,PDLIM5,ACTR3,DNM1L,TBX18,FGFR1
,CAPRIN1,SSH2,NF1,NPR1,PAFAH1B1,IL18,ARPC2,NRP1,PTEN,FYN,
RUNX2,FBXW7,MEF2A,CTSH,SEMA4D,CSF1R,C3,SMAD4,TGFB1I1,D
DAH1,EZR,PTPRD,RUNX1,KIF13B,ANKRD6,PTGIS,ROBO2,NTRK1,BR
WD1,DUSP6,TGFBR3,STK24,SSH1,TENM4,GATA2
1.17
722
031
5
G
O:
00
43
56
6
structure-specific DNA binding
mol
ecul
ar_f
unct
ion
OBFC1,BCL6,FUBP1,PNKP,RAD23A,APITD1,PMS1,YY1,DDX58,ZEB1,
SUB1,SSBP1,ZNF148,ACD,HMGN2,SSBP2,RBMS1,ERCC1,LRPPRC,Z
NF638,USF1,FOXC1
1.30
902
547
4
G
O:
GTPase activator activity
mol
ecul
RAB3GAP2,RALGAPA2,ARHGEF12,STARD13,RANBP1,SIPA1L1,TBC1
D2B,TBC1D10B,TBC1D14,GIT2,FAM13A,NF1,ACAP2,RGS3,ARHGAP9,
1.29
148
G
O:
00
32
25
9
G
O:
00
22
60
3
1.
1
7
E
0
1
1.
1
7
E
0
1
1.
1
8
E
0
1
1.
1
8
E
0
1
1.
1
00
05
09
6
G
O:
00
71
56
0
G
O:
00
33
69
2
G
O:
00
19
43
2
G
O:
00
45
32
1
ar_f
unct
ion
IQGAP1,SRGAP2,TBCD,ARHGAP29,SGSM3,TBC1D22A,ASAP1,RGS2,
BNIP2
33
cellular response to transforming growth
factor beta stimulus
biol
ogic F11R,SMAD7,GLG1,FKBP1A,PTPRK,ZEB1,LTBP4,FLCN,NCOR1,USP1
al_p 5,SMAD4,TGFB1I1,ENG,NOX4,PDGFRB,NCOR2,SMAD9,TGFBR3,PDP
roce K1,FMOD
ss
1.32
735
295
5
cellular polysaccharide biosynthetic process
biol
ogic
al_p GRB10,PHKG2,EXT1,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.68
407
906
2
triglyceride biosynthetic process
biol
ogic
al_p HSD17B12,GPAT2,NR1H3,FBXW7,C3,ELOVL1,LPCAT1
roce
ss
1.68
407
906
2
leukocyte activation
biol
ogic
al_p
roce
ss
CADM1,PSMB10,BTN3A1,SART1,HLADPB1,DPP4,BCL6,PTPN22,IL15RA,LEF1,HLADQA1,ADAM8,MINK1,PTPN6,IGBP1,JAG2,RC3H1,ZC3H12A,POLM,VA
MP7,RNF8,FKBP1A,LCP2,ZEB1,ZNF3,RNF168,IL18,NR1H3,FYN,RUNX
2,NCOR1,MEF2A,CSK,PTPRC,SWAP70,IMPDH1,CDK6,PAK1,NCK2,C
D276,GLI3,ERCC1,LGALS8,TNFRSF14,KIF13B,IGF2,STAT6,NTRK1,CD
1.18
388
686
2
8
E
0
1
1.
1
8
E
0
1
1.
1
9
E
0
1
1.
1
9
E
0
1
1.
2
0
E
0
151,PDPK1
G
O:
00
36
29
3
1
response to decreased oxygen levels
biol
ogic RAF1,BDNF,DPP4,PAM,ADAM8,SLC11A2,MDM2,NF1,ADSL,LMNA,IL1
al_p 8,PAK1,SMAD4,ENG,SCFD1,ARNT,NOX4,PTGIS,SMAD9,TGFBR3,PLO
roce D2,USF1
ss
1.30
571
768
7
blood vessel development
biol
ogic
al_p
roce
ss
1.19
579
578
3
clathrin-coated endocytic vesicle
cell
ular
_co HLA-DPB1,HLA-DQA1,RAB35,EPN2,MYO1E
mpo
nent
1.89
099
024
G
O:
00
05
20
1
extracellular matrix structural constituent
mol
ecul
ar_f
unct
ion
LAMB1,COL9A1,COL2A1,MEPE,COL14A1,COL12A1,COL9A3,COL13A
1,ACAN
1.55
847
263
6
G
O:
positive regulation of neuron differentiation
biol
ogic
BDNF,ACTR3,FGFR1,ZEB1,MEF2A,TCF4,TCF12,BNIP2
1.60
867
G
O:
00
01
56
8
G
O:
00
45
33
4
FZD6,PLCD1,TBX2,SMAD7,RNH1,LEF1,ADAM8,KRIT1,ZC3H12A,AAM
P,STK4,FGFR1,NF1,COL18A1,NPR1,PKD2,SLC12A6,ZFPM2,IL18,ADA
M15,NRP1,PTEN,FBXW7,MEF2A,MYLK,UBP1,CTSH,C3,DDAH1,GLI3,E
NG,ITGA5,PDGFRB,COL8A1,RUNX1,SMARCA4,SETD2,PTGIS,MYO1E
,CLIC4,NTRK1,TGFBR3,PKD1,FOXC1,GATA2
1.
2
0
E
0
1
1.
2
0
E
0
1
1.
2
1
E
0
1
1.
2
2
E
0
1
1.
2
00
45
66
6
G
O:
00
35
66
6
G
O:
00
02
47
4
G
O:
00
31
39
8
G
O:
00
48
72
9
al_p
roce
ss
253
7
TRIF-dependent toll-like receptor signaling
pathway
biol
ogic
al_p NOD1,TAB2,CREB1,RPS6KA5,IKBKB,MEF2A,MAPK8,DUSP6
roce
ss
1.60
867
253
7
antigen processing and presentation of
peptide antigen via MHC class I
biol
ogic
PSMB10,HLA-C,PSMB9,SEC31A,ITGB5,HLAal_p
F,PSMC6,PSMC4,CANX,PDIA3,PSMA1
roce
ss
1.48
198
957
4
positive regulation of protein ubiquitination
biol
ogic
PSMB10,SMAD7,PSMB9,APITD1,ANAPC4,PLK1,SEPT4,FKBP1A,PTEN
al_p
,FBXW7,PSMC6,PSMC4,CDC14B,PSMA1
roce
ss
1.40
758
846
9
tissue morphogenesis
biol
ogic
al_p
roce
ss
1.19
344
185
5
FZD6,IGF1R,NPHP3,TBX2,SMAD7,LEF1,PAX8,VASP,PRKACA,JAG2,T
BX18,STK4,FGFR1,FKBP1A,PKD2,ZFPM2,NRP1,ALDH1A3,IFT172,PX
N,MEF2A,TCTN1,MYLK,TRIM28,PAK1,RAB10,CTSH,CSF1R,SMAD4,T
GFB1I1,GLI3,TMED2,ENG,GAA,ITGA5,RUNX1,SMARCA4,ANKRD6,SE
TD2,CLIC4,TGFBR3,PKD1,FOXC1,C2CD3,EYA2
2
E
0
1
1.
2
2
E
0
1
1.
2
2
E
0
1
1.
2
2
E
0
1
1.
2
3
E
0
1
G
O:
00
71
55
9
response to transforming growth factor beta
stimulus
biol
ogic F11R,SMAD7,GLG1,FKBP1A,PTPRK,ZEB1,LTBP4,FLCN,NCOR1,USP1
al_p 5,SMAD4,TGFB1I1,ENG,NOX4,PDGFRB,NCOR2,SMAD9,TGFBR3,PDP
roce K1,FMOD
ss
1.32
084
632
3
mRNA stabilization
biol
ogic
al_p DHX9,PAIP1,CIRBP,PABPC1
roce
ss
2.07
271
269
1
metanephric nephron morphogenesis
biol
ogic
al_p PAX8,PKD2,PDGFRB,PKD1
roce
ss
2.07
271
269
1
G
O:
00
44
24
7
cellular polysaccharide catabolic process
biol
ogic
al_p PHKG2,GAA,PGM2,PHKG1
roce
ss
2.07
271
269
1
G
O:
glucan catabolic process
biol
ogic
2.07
271
G
O:
00
48
25
5
G
O:
00
72
27
3
PHKG2,GAA,PGM2,PHKG1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
00
09
25
1
G
O:
00
90
32
9
G
O:
00
01
95
4
G
O:
00
45
12
4
G
O:
00
43
48
9
al_p
roce
ss
269
1
regulation of DNA-dependent DNA
replication
biol
ogic
al_p INO80,FBXW7,STAG2,CIZ1
roce
ss
2.07
271
269
1
positive regulation of cell-matrix adhesion
biol
ogic
al_p UTRN,PPM1F,PLEKHA2,CDK6
roce
ss
2.07
271
269
1
regulation of bone resorption
biol
ogic
al_p ADAM8,NF1,CSK,CSF1R
roce
ss
2.07
271
269
1
RNA stabilization
biol
ogic
al_p DHX9,PAIP1,CIRBP,PABPC1
roce
ss
2.07
271
269
1
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
G
O:
00
00
04
5
autophagic vacuole assembly
biol
ogic
al_p ATG4B,TBC1D14,ATG12,ATG3
roce
ss
2.07
271
269
1
RNA polyadenylation
biol
ogic
al_p SYMPK,PAF1,CSTF1,PABPC1
roce
ss
2.07
271
269
1
T cell selection
biol
ogic
al_p MINK1,JAG2,PTPRC,GLI3
roce
ss
2.07
271
269
1
G
O:
00
16
57
1
histone methylation
biol
ogic
al_p EED,EHMT1,PRMT5,SETD8,WDR61,PHF1,SETD2,BAZ2A,PHF19
roce
ss
1.55
453
451
8
G
O:
positive regulation of response to DNA
damage stimulus
biol
ogic
1.75
729
G
O:
00
43
63
1
G
O:
00
45
05
8
BCLAF1,RNF8,RNF168,TRIM28,NSMCE4A,SPRED1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
20
01
02
2
G
O:
00
33
11
6
G
O:
00
44
32
7
G
O:
00
14
06
9
G
O:
00
70
48
2
al_p
roce
ss
989
endoplasmic reticulum-Golgi intermediate
compartment membrane
cell
ular
_co LMAN2,CLN8,TMED3,TMED2
mpo
nent
2.07
308
559
6
dendritic spine head
cell
ular
SIPA1L1,MINK1,PDLIM5,PLCB4,SHARPIN,FYN,SRGAP2,RAB8A,GOP
_co
C,TANC1,PSD3
mpo
nent
1.48
006
351
4
postsynaptic density
cell
ular
SIPA1L1,MINK1,PDLIM5,PLCB4,SHARPIN,FYN,SRGAP2,RAB8A,GOP
_co
C,TANC1,PSD3
mpo
nent
1.48
006
351
4
response to oxygen levels
biol
ogic RAF1,BDNF,DPP4,PAM,ADAM8,SLC11A2,MDM2,NF1,ADSL,LMNA,IL1
al_p 8,PAK1,SMAD4,ENG,SCFD1,ARNT,NOX4,PDGFRB,PTGIS,SMAD9,TG
roce FBR3,PLOD2,USF1
ss
1.29
112
728
1
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
3
E
0
1
1.
2
4
E
0
1
G
O:
00
51
16
8
nuclear export
biol
ogic
UHMK1,DDX39A,PRKACA,NUTF2,UPF1,FYTTD1,MDM2,SRSF10,THO
al_p
C2,NCBP2,SDAD1,PKD1,PABPN1
roce
ss
1.42
393
676
8
specification of organ identity
biol
ogic
al_p PAX8,FGFR1,SMARCD3,MEF2A,GLI3
roce
ss
1.87
119
895
7
cell fate commitment involved in formation
of primary germ layer
biol
ogic
al_p FGFR1,PAF1,DUSP6,FOXC1,EYA2
roce
ss
1.87
119
895
7
G
O:
00
60
42
0
regulation of heart growth
biol
ogic
al_p TBX2,FGFR1,MEF2A,GSK3A,DUSP6
roce
ss
1.87
119
895
7
G
O:
Cajal body
cell
ular
1.74
916
G
O:
00
10
09
2
G
O:
00
60
79
5
SART1,EFTUD2,PRPF3,SRRM2,HINFP,TGS1
1.
2
5
E
0
1
1.
2
5
E
0
1
1.
2
5
E
0
1
1.
2
5
E
0
1
1.
2
00
15
03
0
G
O:
00
05
88
1
G
O:
00
05
77
4
G
O:
00
42
16
2
G
O:
00
35
03
5
_co
mpo
nent
597
2
cytoplasmic microtubule
cell
ular
_co HDAC6,PAFAH1B1,BICD1,SS18,CLIP2,CLASP1
mpo
nent
1.74
916
597
2
vacuolar membrane
cell
ular HLA-DPB1,ATP6V1D,HLA-DQA1,NPC1,SLC11A2,VAMP7,HLA_co DMB,TPCN2,IFITM3,CTNS,ABCA2,ATP6V0A1,HGSNAT,MCOLN1,GAA,
mpo CD164,CCZ1B,CD63
nent
1.33
978
670
2
telomeric DNA binding
mol
ecul
ar_f
unct
ion
OBFC1,TP53BP1,ACD
2.38
354
638
5
histone acetyltransferase binding
mol
ecul
ar_f
unct
ion
SIRT2,MEF2A,GLI3
2.38
354
638
5
5
E
0
1
1.
2
5
E
0
1
1.
2
5
E
0
1
1.
2
7
E
0
1
1.
2
7
E
0
1
G
O:
00
44
08
7
regulation of cellular component biogenesis
biol
ogic
al_p
roce
ss
endochondral bone growth
biol
ogic
al_p COL9A1,THBS3,EVC
roce
ss
2.37
752
338
1
semaphorin-plexin signaling pathway
biol
ogic
al_p NRP1,SEMA6A,SEMA4D
roce
ss
2.37
752
338
1
G
O:
00
03
30
9
type B pancreatic cell differentiation
biol
ogic
al_p CDK6,GSK3A,PDPK1
roce
ss
2.37
752
338
1
G
O:
embryonic placenta morphogenesis
biol
ogic
2.37
752
G
O:
00
03
41
6
G
O:
00
71
52
6
CRBN,RAF1,BDNF,HDAC6,ARPC4TTLL3,BCL2L11,CAPZB,PDLIM5,ACTR3,PRKACA,BCLAF1,TBC1D14,S
NCAIP,PRKCH,PPM1F,SSH2,RB1,ARPC2,PTEN,MEF2A,WASH4P,VILL
,TBCD,PAK1,NCK2,ACTR2,FHOD1,RAB5A,NOX4,NLGN2,TWF1,ROBO
2,SENP6,SSH1
LEF1,TRIM28,SETD2
1.22
478
477
2
1.
2
7
E
0
1
1.
2
7
E
0
1
1.
2
7
E
0
1
1.
2
7
E
0
1
1.
2
00
60
66
9
G
O:
00
45
19
1
G
O:
00
71
88
7
G
O:
00
43
08
6
G
O:
00
08
28
9
al_p
roce
ss
338
1
regulation of isotype switching
biol
ogic
al_p BCL6,PTPRC,STAT6
roce
ss
2.37
752
338
1
leukocyte apoptotic process
biol
ogic
al_p NOC2L,BCL6,BCL2L11,ADAM8,PTEN,MEF2A,GLI3
roce
ss
1.65
453
381
5
negative regulation of catalytic activity
biol
ogic
al_p
roce
ss
lipid binding
mol
ecul
ar_f
unct
ion
PSMB10,IGF1R,MYO1D,RAF1,SMAD7,HDAC6,RNH1,LEF1,PSMB9,US
P47,PTPN6,CSNK2A1,IGBP1,ANAPC4,PLK1,CLN8,TNK2,MDM2,FKBP1
A,PPM1F,ZCCHC9,SERPINH1,NF1,RTKN,RB1,SYTL2,ANXA5,SH3BP5,
BICD1,RGS3,PTEN,IQGAP1,PHPT1,HERPUD1,PPP1R10,PRKRIP1,CS
K,PTPRC,OAZ1,PSMC6,PSMC4,LEPR,SEMA4D,DGKZ,C3,TMED2,ENG
,RGS2,FARP1,GSK3A,PDCD4,CRIPAK,PSMA1,CDK5RAP1,SPRED1,D
USP6,CPAMD8,PDPK1,WNK1
PLEKHA3,LAMB1,PLCD1,PLD1,GPAA1,MCF2L,ARHGEF12,LANCL2,S
YTL4,DGKA,ARHGEF25,NISCH,RAB35,CMIP,TBC1D2B,NPC1,AFAP1,
SGK1,PLEKHG4,ZCCHC14,ZFYVE26,RALGPS2,PLEKHG5,SNX13,SNX
21,RTKN,PLEKHA2,STARD3,ACBD4,SYTL2,EPN2,ACAP2,ANXA5,NR1
H3,CYTH2,GRB10,PXDC1,ARHGAP9,PTEN,SNX17,SH3BP2,OSBPL3,S
WAP70,NSFL1C,APPL2,HSD17B4,GOLPH3,APOL3,RASGRF2,EPN1,A
1.16
041
652
1
1.15
257
709
6
7
E
0
1
1.
2
7
E
0
1
1.
2
8
E
0
1
1.
2
8
E
0
1
1.
2
8
E
0
RHGEF7,PHF12,ASAP1,FARP1,SNX27,ADRBK2,TWF1,PCYT1A,WDFY
3,MYO1E,SNX14,PSMA1,PSD3,PGRMC2
G
O:
00
06
02
4
1
glycosaminoglycan biosynthetic process
biol
ogic
ST3GAL1,XYLT1,ST3GAL4,GCNT2,UST,B4GALT4,EXT1,B3GAT3,PDG
al_p
FRB,ACAN,FMOD
roce
ss
1.46
731
641
positive regulation of DNA metabolic
process
biol
ogic
OBFC1,IGF1R,RNF8,INO80,RNF168,TRIM28,PTPRC,NOX4,CIZ1,PDGF
al_p
RB,STAT6
roce
ss
1.46
731
641
chordate embryonic development
biol
ogic
al_p
roce
ss
FZD6,NPHP3,PLCD1,COL2A1,LEF1,BCL2L11,VASP,JAG2,TBX18,STK4
,FGFR1,NF1,ZEB1,NIPBL,PKD2,RXRB,MAPK8IP3,ZFPM2,EPN2,FLCN,
RUNX2,IFT172,MEF2A,TCTN1,TRIM28,RARRES2,PSMC4,SMAD4,GLI3
,TMED2,EPN1,VEZT,ARNT,EXT1,MDFI,HINFP,PDGFRB,RUNX1,SMAR
CA4,NCOR2,SETD2,MYO1E,BNIP2,TGFBR3,EGFL8,PKD1,FOXC1,C2C
D3,GATA2
1.17
885
534
3
G
O:
00
02
28
5
lymphocyte activation involved in immune
response
biol
ogic
BCL6,LEF1,RC3H1,RNF8,RNF168,PTPRC,SWAP70,ERCC1,LGALS8,S
al_p
TAT6
roce
ss
1.49
695
916
6
G
O:
muscle organ morphogenesis
biol
ogic
1.58
501
G
O:
00
51
05
4
G
O:
00
43
00
9
CNTF,SMAD7,FKBP1A,ZFPM2,MYLK,GAA,TGFBR3,FOXC1
1.
2
8
E
0
1
1.
2
8
E
0
1
1.
2
9
E
0
1
1.
3
0
E
0
1
1.
3
00
48
64
4
al_p
roce
ss
558
7
positive regulation of signal transduction
IGF1R,RAF1,CNTF,HDAC6,LANCL2,BCL2L11,RBPMS,XBP1,ADAM8,MI
NK1,PTPN6,CSNK2A1,NOD1,DNM1L,PPP5C,SHISA5,SEPT4,MIB2,BCL
biol AF1,FGFR1,DISP1,TAB2,SHARPIN,FKBP1A,PRKCH,NPTN,PLEKHG5,
ogic PKD2,MAPK8IP3,PAFAH1B1,NR1H3,GRB10,PLK2,FLCN,FBXW7,IKBK
al_p B,PXN,LTBR,MAPK8,SH3BP2,CSK,PTPRC,RNF146,AAK1,PAK1,EVC,R
roce HEB,SEMA4D,CSF1R,C3,SMAD4,C1QTNF3,TGFB1I1,GOLPH3,APOL3,
ss
FLNA,ENG,ARNT,NOX4,STK36,MDFI,ITGA5,PDGFRB,GSK3A,ANKRD6
,IGF2,PTGIS,CSNK1E,BNIP2,NTRK1,SPRED1,TNFRSF10B,TGFBR3,L
MCD1,UBR5,CC2D1A
PML body
cell
ular
_co CBX5,RB1,SENP2,USP7,CHFR,PTEN,PIAS2,MKNK2,ZBTB16
mpo
nent
1.53
585
304
8
G
O:
00
07
28
6
spermatid development
biol
ogic
al_p PRKACA,SEPT4,CELF1,RNF8,PAFAH1B1,PLD6,SRPK1,AFF4,GOPC
roce
ss
1.53
485
686
6
G
O:
00
42
antigen processing and presentation of
exogenous peptide antigen via MHC class I
biol
ogic
PSMB10,HLA-C,PSMB9,ITGB5,HLA-F,PSMC6,PSMC4,PDIA3,PSMA1
al_p
roce
1.53
485
686
6
G
O:
00
09
96
7
G
O:
00
16
60
5
1.13
642
627
0
E
0
1
1.
3
0
E
0
1
1.
3
0
E
0
1
1.
3
0
E
0
1
1.
3
0
E
59
0
G
O:
00
30
81
1
ss
regulation of nucleotide catabolic process
biol
ogic
al_p
roce
ss
G
O:
00
42
40
5
nuclear inclusion body
cell
ular
_co NUP98,ATXN3
mpo
nent
3.10
962
839
4
G
O:
00
16
70
6
oxidoreductase activity, acting on paired
donors, with incorporation or reduction of
molecular oxygen, 2-oxoglutarate as one
donor, and incorporation of one atom each
of oxygen into both donors
mol
ecul
ar_f
unct
ion
1.72
426
759
8
aminoglycan metabolic process
biol
ogic
ST3GAL1,XYLT1,ST3GAL4,GCNT2,HEXA,UST,HGSNAT,GUSB,B4GAL
al_p
T4,EXT1,B3GAT3,PDGFRB,CTBS,FOXC1,ACAN,FMOD
roce
ss
G
O:
00
06
02
2
RAB3GAP2,RALGAPA2,BCL6,ARHGEF12,STARD13,DNAJC10,RANBP
1,SIPA1L1,TBC1D2B,TBC1D10B,TBC1D14,GIT2,FAM13A,SNX13,NF1,
PAFAH1B1,ACAP2,RGS3,ARHGAP9,IQGAP1,SRGAP2,TBCD,ARHGAP
29,SGSM3,SEMA4D,TBC1D22A,TMED2,ARHGEF7,ASAP1,RGS2,GSK
3A,BNIP2,NTRK1,RAPGEF6
LEPRE1,JHDM1D,ALKBH3,OGFOD3,P4HB,PLOD2
1.22
151
867
9
1.35
573
660
3
0
1
1.
3
0
E
0
1
1.
3
1
E
0
1
1.
3
2
E
0
1
1.
3
2
E
0
1
G
O:
00
46
82
2
G
O:
00
06
31
0
G
O:
00
19
05
8
G
O:
00
43
00
5
G
O:
00
43
regulation of nucleocytoplasmic transport
biol
ogic
RBPMS,UHMK1,PRKACA,MDM2,DDX58,NF1,PKD2,SMAD4,C1QTNF3,
al_p
FLNA,GLI3,MDFI,NCBP2,PKD1,KPNA1,UBR5
roce
ss
1.35
573
660
3
DNA recombination
biol
ogic BCL6,LEF1,APITD1,POLM,PMS1,RNF8,ZFYVE26,YY1,INO80,TP53BP1
al_p ,RNF168,PTPRC,SWAP70,ZSWIM7,INO80E,ERCC1,RAD51B,STAT6,N
roce SMCE4A,KPNA1,SMARCAD1
ss
1.29
782
239
6
viral infectious cycle
biol
ogic SUPT5H,VAPB,LEF1,SUPT4H1,RAD23A,RPL27,IFITM3,RPL9,RPL24,R
al_p PL37A,SRPK1,KPNB1,UBP1,RPL4,SLC25A6,NCBP2,SMARCA4,RPLP0
roce ,TSG101,USF1,KPNA1,PABPN1
ss
1.28
868
658
6
neuron projection
cell
ular
_co
mpo
nent
FZD6,CADM1,IGF1R,MYO1D,SEPT5,UBXN1,FMR1,PAM,MARK4,UHM
K1,SIPA1L1,MINK1,PDLIM5,PPP5C,VAMP7,CAMK2D,PLCB4,TNK2,CA
PRIN1,ADCY4,SHARPIN,SNAP23,FKBP1A,PTPRK,NF1,NEK3,STRN4,
MAPK8IP3,PAFAH1B1,PLK2,NRP1,PTEN,FYN,IQGAP1,SRGAP2,MYCB
P2,RAB8A,AAK1,GOPC,PAK1,RHEB,SEMA6A,GNB3,ROBO3,ARHGEF
7,FARP1,CANX,KIF13B,TANC1,PSD3,ROBO2,NTRK1,KPNA1,TENM4
1.16
611
064
8
muscle adaptation
biol
ogic
CAMK2D,MEF2A,TBCE,RGS2,GSK3A,LMCD1
al_p
roce
1.71
991
053
1
1.
3
2
E
0
1
1.
3
2
E
0
1
1.
3
2
E
0
1
1.
3
3
E
0
1
1.
3
3
E
50
0
G
O:
00
48
01
0
G
O:
00
30
42
4
G
O:
00
61
06
1
G
O:
00
31
39
6
ss
vascular endothelial growth factor receptor
signaling pathway
biol
ogic
al_p GRB10,NRP1,ARNT,ITGA5,PDGFRB,FOXC1
roce
ss
1.71
991
053
1
axon
cell
ular CADM1,MYO1D,SEPT5,UHMK1,MINK1,CAMK2D,TNK2,FKBP1A,PTPR
_co K,NF1,NEK3,MAPK8IP3,PAFAH1B1,NRP1,MYCBP2,AAK1,PAK1,SEMA
mpo 6A,ROBO3,CANX,KIF13B,TANC1,ROBO2,NTRK1
nent
1.27
212
070
7
muscle structure development
biol
ogic
al_p
roce
ss
SIRT2,UTRN,BDNF,TAZ,SIN3B,LUC7L,TBX2,CNTF,SMAD7,LEF1,TBX1
8,FGFR1,DISP1,FKBP1A,NF1,ZEB1,MED28,RXRB,LMNA,RB1,ZFPM2,
SYNE1,SMARCD3,MEF2A,MYLK,PAK1,EVC,DTYMK,MAPK12,TCF12,G
AA,HINFP,PDGFRB,SMARCA4,CD164,GSK3A,ITGA11,GPHN,TANC1,B
NIP2,TGFBR3,FOXC1
1.19
126
434
7
regulation of protein ubiquitination
biol
ogic PSMB10,UBXN1,SMAD7,USP4,PSMB9,APITD1,ANAPC4,PLK1,SEPT4,
al_p FKBP1A,PTEN,FBXW7,HERPUD1,PSMC6,PSMC4,CDC14B,PSMA1,UB
roce R5
ss
1.32
517
696
7
0
1
1.
3
3
E
0
1
1.
3
3
E
0
1
1.
3
4
E
0
1
1.
3
5
E
0
1
G
O:
00
51
09
8
G
O:
00
43
54
7
G
O:
00
06
02
3
G
O:
00
50
76
7
G
O:
00
07
regulation of binding
biol
ogic
CRBN,LEF1,KRIT1,PLK1,FKBP1A,SENP2,NRP1,SMARCD3,HERPUD1,
al_p
MEF2A,MAPK8,ACD,SMAD4,LRPAP1,MDFI,SMARCA4,TGFBR3,PKD1
roce
ss
1.32
517
696
7
positive regulation of GTPase activity
biol
ogic
al_p
roce
ss
RAB3GAP2,RALGAPA2,ARHGEF12,STARD13,RANBP1,SIPA1L1,TBC1
D2B,TBC1D10B,TBC1D14,GIT2,FAM13A,SNX13,NF1,ACAP2,RGS3,AR
HGAP9,IQGAP1,SRGAP2,TBCD,ARHGAP29,SGSM3,SEMA4D,TBC1D2
2A,ARHGEF7,ASAP1,RGS2,BNIP2,NTRK1
1.24
499
574
2
aminoglycan biosynthetic process
biol
ogic
ST3GAL1,XYLT1,ST3GAL4,GCNT2,UST,B4GALT4,EXT1,B3GAT3,PDG
al_p
FRB,ACAN,FMOD
roce
ss
1.45
293
095
5
regulation of neurogenesis
biol
ogic
al_p
roce
ss
BDNF,CNTF,SIPA1L1,PDLIM5,ACTR3,FGFR1,CAPRIN1,PRKCH,SSH2,
NPTN,NF1,ZEB1,PAFAH1B1,NRP1,PTEN,FYN,SMARCD3,SRGAP2,ME
F2A,CDK5RAP2,SEMA6A,TCF4,SEMA4D,GLI3,TCF12,PTPRD,KIF13B,
ROBO2,PMP22,CDK5RAP1,BNIP2,NTRK1,STK24,SSH1,CDK5RAP3,TE
NM4
1.20
951
314
2
cell adhesion
biol
ogic
al_p
roce
LPP,CADM1,LAMB1,UTRN,GP1BB,F11R,COL2A1,DPP4,BCL6,SMAD7,
CD72,LEF1,ITGA9,BCL2L11,HSD17B12,ADAM8,CD9,MINK1,COL16A1,
JAG2,SYMPK,LSAMP,TBX18,JAM2,COL14A1,TRO,COL12A1,PPM1F,T
LN2,THBS3,NPTN,PTPRK,MAGI1,NF1,LGALS3BP,RGMB,COL18A1,IT
1.12
852
454
2
1.
3
5
E
0
1
1.
3
5
E
0
1
1.
3
5
E
0
1
1.
3
5
E
0
1
1.
3
5
E
15
5
G
O:
00
43
02
1
G
O:
00
06
73
2
G
O:
00
46
47
4
G
O:
00
48
48
7
ss
GA3,PLEKHA2,IL18,ESAM,ARPC2,ADAM15,CYTH2,FLCN,NRP1,PTEN,
PXN,SRGAP2,PTPRF,ITGB5,CLSTN2,PTPRS,PTPRC,TBCD,CDK6,ABI
3BP,TMEM8A,PCDH7,TRPM7,SEMA4D,TGFB1I1,EZR,VEZT,ENG,PPFI
A1,PTPRD,ITGA5,COL8A1,TLN1,CD164,SDK2,ITGA11,NLGN2,COL13A
1,ATXN3,ROBO2,CD151,PKD1,PDPK1,ACAN
0
1
ribonucleoprotein complex binding
mol
ecul
ar_f
unct
ion
coenzyme metabolic process
biol
ogic
PTS,SHMT2,H6PD,HSD17B12,PNPO,FDXR,PDXK,GCDH,NADSYN1,N
al_p
ADK,FMO2,IDH1,HSD17B4,ELOVL1,DLST,IDH3B,FPGS,GPHN,PANK3
roce
ss
1.31
271
803
8
glycerophospholipid biosynthetic process
biol
ogic
TAZ,PLD1,GPAA1,PGS1,PIGS,PIGG,PIGN,CHKB,GPAT2,GPCPD1,PLD
al_p
6,MTMR14,PTEN,MBOAT2,LPCAT1,PCYT1A,PIGO,ALG9,PLA2G16
roce
ss
1.31
271
803
8
beta-tubulin binding
mol
ecul
ar_f
unct
ion
2.00
100
190
4
UHMK1,SRP9,PRMT5,ERAL1,TIMM50,NAA10,NAA16
VAPB,HDAC6,TBCD,LRPPRC
1.63
012
655
1
1.
3
5
E
0
1
1.
3
5
E
0
1
1.
3
5
E
0
1
1.
3
5
E
0
1
G
O:
00
01
82
2
kidney development
biol
ogic NPHP3,PAX8,ADAMTS1,BCL2L11,NF1,NIPBL,PKD2,FLCN,TENC1,IQG
al_p AP1,MEF2A,CTSH,SMAD4,GLI3,PDGFRB,MYO1E,ROBO2,ZBTB16,PK
roce D1,FOXC1
ss
1.30
170
362
3
cilium membrane
cell
ular
_co BBS1,CLTB,EVC,SEPT2
mpo
nent
1.99
904
682
5
fatty-acyl-CoA metabolic process
biol
ogic
al_p HSD17B12,GCDH,HSD17B4,ELOVL1
roce
ss
1.99
594
555
5
G
O:
00
21
84
6
cell proliferation in forebrain
biol
ogic
al_p EMX2,FGFR1,GLI3,NCOR2
roce
ss
1.99
594
555
5
G
O:
positive regulation of autophagy
biol
ogic
1.99
594
G
O:
00
60
17
0
G
O:
00
35
33
7
SUPT5H,ZC3H12A,ATG4B,WAC
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
00
10
50
8
G
O:
00
34
39
4
G
O:
00
51
49
6
G
O:
00
32
10
7
G
O:
00
32
10
4
al_p
roce
ss
555
5
protein localization to cell surface
biol
ogic
al_p USP4,PTPRK,LEPROT,FLNA
roce
ss
1.99
594
555
5
positive regulation of stress fiber assembly
biol
ogic
al_p PPM1F,PAK1,FHOD1,NOX4
roce
ss
1.99
594
555
5
regulation of response to nutrient levels
biol
ogic
al_p SUPT5H,NPC1,TBC1D14,WAC,NRBP2
roce
ss
1.82
062
601
3
regulation of response to extracellular
stimulus
biol
ogic
al_p SUPT5H,NPC1,TBC1D14,WAC,NRBP2
roce
ss
1.82
062
601
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
G
O:
00
45
81
4
negative regulation of gene expression,
epigenetic
biol
ogic
al_p SIRT2,CREBZF,SMARCA4,BAZ2A,RRP8
roce
ss
1.82
062
601
3
detection of mechanical stimulus
biol
ogic
al_p PKD2,IL18,FYN,NTRK1,PKD1
roce
ss
1.82
062
601
3
embryonic heart tube morphogenesis
biol
ogic
al_p NPHP3,TBX2,PKD2,MEF2A,TMED2,ENG,C2CD3
roce
ss
1.62
600
737
G
O:
00
06
52
1
regulation of cellular amino acid metabolic
process
biol
ogic
al_p PSMB10,PAX8,PSMB9,OAZ1,PSMC6,PSMC4,PSMA1
roce
ss
1.62
600
737
G
O:
ER to Golgi vesicle-mediated transport
biol
ogic
1.62
600
G
O:
00
50
98
2
G
O:
00
03
14
3
VAMP7,SEC31A,STX18,GOPC,TMED2,SCFD1,LMF1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
00
06
88
8
G
O:
00
46
46
0
G
O:
00
46
46
3
G
O:
00
50
86
3
G
O:
00
02
52
0
al_p
roce
ss
737
neutral lipid biosynthetic process
biol
ogic
al_p HSD17B12,GPAT2,NR1H3,FBXW7,C3,ELOVL1,LPCAT1
roce
ss
1.62
600
737
acylglycerol biosynthetic process
biol
ogic
al_p HSD17B12,GPAT2,NR1H3,FBXW7,C3,ELOVL1,LPCAT1
roce
ss
1.62
600
737
regulation of T cell activation
biol
ogic SART1,HLA-DPB1,DPP4,BCL6,PTPN22,HLAal_p DQA1,ADAM8,PTPN6,RC3H1,ZEB1,IL18,FYN,CSK,PTPRC,PAK1,NCK2
roce ,CD276,GLI3,LGALS8,TNFRSF14,IGF2,PDPK1
ss
1.28
310
785
7
immune system development
biol
ogic
al_p
roce
ss
CRIP2,CDK13,TAZ,SART1,BCL6,PTPN22,IL15RA,LEF1,BCL2L11,ADA
M8,MINK1,PTPN6,JAG2,RC3H1,POLM,SLC11A2,STK4,PAF1,RNF8,NF
1,ZEB1,MITF,RB1,RNF168,PAFAH1B1,FLCN,RUNX2,NCOR1,MEF2A,T
TC7A,FECH,PTPRC,SWAP70,CDK6,WDR61,CSF1R,GLI3,ARNT,ERCC
1,LGALS8,RUNX1,MKNK2,SMARCA4,CD164,MYO1E,STAT6,ACIN1,NT
RK1,TGFBR3,ZBTB16,GATA2
1.16
854
465
5
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
1.
3
6
E
0
1
G
O:
00
09
11
8
regulation of nucleoside metabolic process
biol
ogic
al_p
roce
ss
RAB3GAP2,RALGAPA2,BCL6,ARHGEF12,STARD13,DNAJC10,RANBP
1,SIPA1L1,TBC1D2B,TBC1D10B,TBC1D14,GIT2,FAM13A,SNX13,NF1,
PAFAH1B1,ACAP2,RGS3,FLCN,ARHGAP9,IQGAP1,SRGAP2,TBCD,AR
HGAP29,SGSM3,SEMA4D,TBC1D22A,TMED2,ARHGEF7,ASAP1,RGS2
,BNIP2,NTRK1,RAPGEF6
1.21
503
847
4
regulation of neuron differentiation
biol
ogic
al_p
roce
ss
BDNF,CNTF,SIPA1L1,PDLIM5,ACTR3,FGFR1,CAPRIN1,SSH2,NPTN,Z
EB1,PAFAH1B1,NRP1,PTEN,FYN,MEF2A,CDK5RAP2,TCF4,SEMA4D,
GLI3,TCF12,PTPRD,KIF13B,ROBO2,PMP22,CDK5RAP1,BNIP2,NTRK1,
STK24,SSH1,CDK5RAP3
1.23
225
297
2
mitochondrial inner membrane
cell
ular
_co
mpo
nent
SLC25A37,ACADVL,TAZ,SHMT2,PGS1,TTC19,FDXR,HERC2,CNP,GC
DH,ALDH18A1,TIMM23,DHRS1,MTCH1,SRGAP2,FECH,ERAL1,COX7A
2L,TIMM50,GRPEL2,BCS1L,ATP5A1,NDUFV1,NDUFS2,SLC25A6,SDH
A,POLG,FPGS,SLC25A24,SLC25A46,LETM1,UQCRH
1.22
346
035
2
G
O:
00
51
09
9
positive regulation of binding
biol
ogic
al_p CRBN,KRIT1,FKBP1A,NRP1,HERPUD1,MEF2A,ACD,SMARCA4,PKD1
roce
ss
1.51
567
115
6
G
O:
epithelial to mesenchymal transition
biol
ogic
1.51
567
G
O:
00
45
66
4
G
O:
00
05
74
3
SMAD7,LEF1,ADAM15,TRIM28,SMAD4,TGFB1I1,FLNA,TGFBR3,FOXC
1
1.
3
7
E
0
1
1.
3
7
E
0
1
1.
3
7
E
0
1
1.
3
8
E
0
1
1.
3
00
01
83
7
G
O:
00
00
80
6
G
O:
00
45
18
0
G
O:
00
30
98
1
G
O:
00
97
19
6
al_p
roce
ss
115
6
Y chromosome
cell
ular
_co SIN3B
mpo
nent
6.99
666
388
7
basal cortex
cell
ular
_co PKD2
mpo
nent
6.99
666
388
7
cortical microtubule cytoskeleton
cell
ular
_co CLASP1
mpo
nent
6.99
666
388
7
Shu complex
cell
ular
_co ZSWIM7
mpo
nent
6.99
666
388
7
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
G
O:
00
33
64
8
host intracellular membrane-bounded
organelle
cell
ular
_co BICD1
mpo
nent
6.99
666
388
7
rough endoplasmic reticulum lumen
cell
ular
_co LRPAP1
mpo
nent
6.99
666
388
7
angiogenin-PRI complex
cell
ular
_co RNH1
mpo
nent
6.99
666
388
7
G
O:
00
31
52
3
Myb complex
cell
ular
_co FLNA
mpo
nent
6.99
666
388
7
G
O:
cytoplasmic cyclin-dependent protein kinase
holoenzyme complex
cell
ular
6.99
666
G
O:
00
48
23
7
G
O:
00
32
31
1
CDK14
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
00
00
30
8
G
O:
00
05
76
0
G
O:
00
70
43
6
G
O:
00
45
25
2
G
O:
00
30
84
9
_co
mpo
nent
388
7
gamma DNA polymerase complex
cell
ular
_co POLG
mpo
nent
6.99
666
388
7
Grb2-EGFR complex
cell
ular
_co TNK2
mpo
nent
6.99
666
388
7
oxoglutarate dehydrogenase complex
cell
ular
_co DLST
mpo
nent
6.99
666
388
7
autosome
cell
ular
_co SIN3B
mpo
nent
6.99
666
388
7
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
G
O:
00
02
94
5
cyclin K-CDK13 complex
cell
ular
_co CDK13
mpo
nent
6.99
666
388
7
host intracellular organelle
cell
ular
_co BICD1
mpo
nent
6.99
666
388
7
alpha9-beta1 integrin-vascular cell adhesion
molecule-1 complex
cell
ular
_co ADAM8
mpo
nent
6.99
666
388
7
G
O:
00
02
75
6
MyD88-independent toll-like receptor
signaling pathway
biol
ogic
al_p NOD1,TAB2,CREB1,RPS6KA5,IKBKB,MEF2A,MAPK8,DUSP6
roce
ss
1.56
204
434
7
G
O:
toll-like receptor 1 signaling pathway
biol
ogic
1.56
204
G
O:
00
33
64
7
G
O:
00
71
06
5
NOD1,TAB2,CREB1,RPS6KA5,IKBKB,MEF2A,MAPK8,DUSP6
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
8
E
0
1
1.
3
00
34
13
0
G
O:
00
06
28
1
G
O:
00
22
61
0
G
O:
00
48
00
2
G
O:
00
05
al_p
roce
ss
434
7
DNA repair
biol
ogic
al_p
roce
ss
USP10,MMS19,PNKP,RAD23A,APITD1,USP47,UPF1,HERC2,POLM,PM
S1,RNF8,ZFYVE26,YY1,INO80,ALKBH3,USP3,TP53BP1,RNF168,MUM
1,USP7,CUL4A,TRIM28,ZSWIM7,INO80E,CDC14B,ERCC1,HINFP,RAD
51B,POLG,ATXN3,CSNK1E,NSMCE4A,SHPRH,UBR5,EYA2,SMARCAD
1
biological adhesion
LPP,CADM1,LAMB1,UTRN,GP1BB,F11R,COL2A1,DPP4,BCL6,SMAD7,
CD72,LEF1,ITGA9,BCL2L11,HSD17B12,ADAM8,CD9,MINK1,COL16A1,
biol JAG2,SYMPK,LSAMP,TBX18,JAM2,COL14A1,TRO,COL12A1,PPM1F,T
ogic LN2,THBS3,NPTN,PTPRK,MAGI1,NF1,LGALS3BP,RGMB,COL18A1,IT
al_p GA3,PLEKHA2,IL18,ESAM,ARPC2,ADAM15,CYTH2,FLCN,NRP1,PTEN,
roce PXN,SRGAP2,PTPRF,ITGB5,CLSTN2,PTPRS,PTPRC,TBCD,CDK6,ABI
ss
3BP,TMEM8A,PCDH7,TRPM7,SEMA4D,TGFB1I1,EZR,VEZT,ENG,PPFI
A1,PTPRD,ITGA5,COL8A1,TLN1,CD164,SDK2,ITGA11,NLGN2,COL13A
1,ATXN3,ROBO2,CD151,PKD1,PDPK1,ACAN
antigen processing and presentation of
peptide antigen
biol
ogic PSMB10,HLA-DPB1,DYNC1I1,HLA-C,PSMB9,HLA-DQA1,HLAal_p DMB,SEC31A,LGMN,ITGB5,HLAroce F,PSMC6,PSMC4,KLC1,CANX,PDIA3,DYNC1I2,PSMA1
ss
1.31
797
491
8
neurotrophin receptor binding
mol
ecul
ar_f
unct
3.00
150
285
5
BDNF,NTRK1
1.20
650
440
2
1.12
619
528
6
8
E
0
1
1.
3
8
E
0
1
1.
3
9
E
0
1
1.
3
9
E
0
1
1.
3
9
E
16
5
G
O:
00
00
99
3
G
O:
00
08
13
9
G
O:
00
04
37
3
G
O:
00
16
84
0
ion
RNA polymerase II core binding
mol
ecul
ar_f
unct
ion
nuclear localization sequence binding
mol
ecul
ar_f
unct
ion
glycogen (starch) synthase activity
mol
ecul
ar_f
unct
ion
carbon-nitrogen lyase activity
mol
ecul
ar_f
unct
ion
WAC,PAF1
3.00
150
285
5
KPNB1,KPNA1
3.00
150
285
5
GSK3A,IGF2
3.00
150
285
5
PAM,ADSL
3.00
150
285
5
0
1
1.
3
9
E
0
1
1.
3
9
E
0
1
1.
3
9
E
0
1
1.
3
9
E
0
1
G
O:
00
43
53
9
G
O:
00
31
95
3
G
O:
00
01
88
6
G
O:
00
60
97
3
G
O:
00
60
protein serine/threonine kinase activator
activity
mol
ecul
ar_f
unct
ion
negative regulation of protein
autophosphorylation
biol
ogic
al_p PTPRC,ENG
roce
ss
2.99
391
833
2
endothelial cell morphogenesis
biol
ogic
al_p COL18A1,CLIC4
roce
ss
2.99
391
833
2
cell migration involved in heart development
biol
ogic
al_p ENG,PDGFRB
roce
ss
2.99
391
833
2
regulation of microtubule-based movement
biol
ogic
HDAC6,IGBP1
al_p
roce
2.99
391
833
2
STK4,IGF2
3.00
150
285
5
1.
3
9
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
63
2
G
O:
00
60
00
9
ss
Sertoli cell development
biol
ogic
al_p HSD17B4,NTRK1
roce
ss
2.99
391
833
2
somite rostral/caudal axis specification
biol
ogic
al_p SMAD4,TMED2
roce
ss
2.99
391
833
2
G
O:
00
72
17
7
mesonephric duct development
biol
ogic
al_p PKD2,PKD1
roce
ss
2.99
391
833
2
G
O:
00
02
48
0
antigen processing and presentation of
exogenous peptide antigen via MHC class I,
TAP-independent
biol
ogic
al_p HLA-C,HLA-F
roce
ss
2.99
391
833
2
G
O:
00
32
52
5
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
G
O:
00
72
66
8
G
O:
00
06
55
4
G
O:
00
51
00
6
G
O:
00
31
06
5
G
O:
00
40
tubulin complex biogenesis
biol
ogic
al_p TBCD,TBCE
roce
ss
2.99
391
833
2
lysine catabolic process
biol
ogic
al_p GCDH,DLST
roce
ss
2.99
391
833
2
positive regulation of lipoprotein lipase
activity
biol
ogic
al_p NR1H3,LMF1
roce
ss
2.99
391
833
2
positive regulation of histone deacetylation
biol
ogic
al_p NIPBL,NCOR1
roce
ss
2.99
391
833
2
establishment of nucleus localization
biol
ogic
PAFAH1B1,SUN2
al_p
roce
2.99
391
833
2
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
02
3
G
O:
00
43
12
9
G
O:
00
72
01
5
G
O:
20
00
51
5
G
O:
00
34
33
1
ss
surfactant homeostasis
biol
ogic
al_p CTSH,LPCAT1
roce
ss
2.99
391
833
2
glomerular visceral epithelial cell
development
biol
ogic
al_p IQGAP1,MYO1E
roce
ss
2.99
391
833
2
negative regulation of CD4-positive, alphabeta T cell activation
biol
ogic
al_p BCL6,RC3H1
roce
ss
2.99
391
833
2
cell junction maintenance
biol
ogic
al_p CSF1R,NLGN2
roce
ss
2.99
391
833
2
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
G
O:
00
34
58
7
piRNA metabolic process
biol
ogic
al_p PLD6,PIWIL4
roce
ss
2.99
391
833
2
forebrain neuroblast division
biol
ogic
al_p LEF1,FGFR1
roce
ss
2.99
391
833
2
cellular protein complex localization
biol
ogic
al_p RALGAPA2,SMAD7
roce
ss
2.99
391
833
2
G
O:
00
06
55
3
lysine metabolic process
biol
ogic
al_p GCDH,DLST
roce
ss
2.99
391
833
2
G
O:
00
32
negative regulation of telomere
maintenance
biol
ogic
ACD,ERCC1
al_p
roce
2.99
391
833
2
G
O:
00
21
87
3
G
O:
00
34
62
9
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
20
5
G
O:
00
44
06
8
G
O:
00
43
17
1
G
O:
00
46
42
6
G
O:
00
02
90
3
ss
modulation by symbiont of host cellular
process
biol
ogic
al_p BCL2L11,PABPN1
roce
ss
2.99
391
833
2
peptide catabolic process
biol
ogic
al_p TPP1,CTSH
roce
ss
2.99
391
833
2
negative regulation of JAK-STAT cascade
biol
ogic
al_p HGS,LEPROT
roce
ss
2.99
391
833
2
negative regulation of B cell apoptotic
process
biol
ogic
al_p NOC2L,BCL6
roce
ss
2.99
391
833
2
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
G
O:
00
43
55
8
G
O:
00
60
45
7
G
O:
00
10
69
2
G
O:
00
60
59
2
G
O:
00
51
regulation of translational initiation in
response to stress
biol
ogic
al_p EIF2B4,FECH
roce
ss
2.99
391
833
2
negative regulation of digestive system
process
biol
ogic
al_p NR1H3,WNK1
roce
ss
2.99
391
833
2
regulation of alkaline phosphatase activity
biol
ogic
al_p MEF2A,SEMA4D
roce
ss
2.99
391
833
2
mammary gland formation
biol
ogic
al_p TBX2,GLI3
roce
ss
2.99
391
833
2
negative regulation of protein transport
biol
ogic RHBDF1,NF1,PKD2,NR1H3,CSK,GOPC,C1QTNF3,FLNA,MDFI,RHBDF
al_p 2,PKD1
roce
1.43
882
482
9
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
0
E
0
1
1.
4
2
E
22
4
G
O:
00
03
00
6
G
O:
00
03
93
8
G
O:
00
47
19
2
G
O:
00
03
99
8
ss
developmental process involved in
reproduction
biol
ogic
al_p
roce
ss
IMP dehydrogenase activity
mol
ecul
ar_f
unct
ion
1-alkylglycerophosphocholine Oacetyltransferase activity
mol
ecul
ar_f
unct
ion
acylphosphatase activity
mol
ecul
ar_f
unct
ion
FZD6,EIF2B4,IGF1R,ADAMTS1,BCL2L11,PRKACA,SEPT4,CELF1,RNF
8,RHBDD1,CRIP1,NIPBL,CASP2,RXRB,ZFPM2,PAFAH1B1,PLD6,MAS
T2,PTEN,IDH1,SRPK1,RQCD1,AFF4,COL9A3,GOPC,HSD17B4,TMED2
,ERCC1,DZIP1,EPOR,RUNX1,ROBO2,NTRK1,SMAD9,ZBTB16,PKD1,F
OXC1,BCL2L2
1.19
616
830
5
IMPDH1
6.75
338
142
5
LPCAT1
6.75
338
142
5
ACYP2
6.75
338
142
5
0
1
1.
4
2
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
04
06
6
G
O:
00
15
09
3
G
O:
00
04
10
5
G
O:
00
70
84
0
G
O:
00
70
asparagine synthase (glutaminehydrolyzing) activity
mol
ecul
ar_f
unct
ion
ferrous iron transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
choline-phosphate cytidylyltransferase
activity
mol
ecul
ar_f
unct
ion
dynein complex binding
mol
ecul
ar_f
unct
ion
serine binding
mol
ecul
ar_f
unct
ASNS
6.75
338
142
5
SLC11A2
6.75
338
142
5
PCYT1A
6.75
338
142
5
HDAC6
6.75
338
142
5
THNSL2
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
90
5
G
O:
00
48
76
3
G
O:
00
08
52
0
G
O:
00
30
15
8
G
O:
00
15
22
9
ion
calcium-induced calcium release activity
mol
ecul
ar_f
unct
ion
L-ascorbate:sodium symporter activity
mol
ecul
ar_f
unct
ion
protein xylosyltransferase activity
mol
ecul
ar_f
unct
ion
L-ascorbic acid transporter activity
mol
ecul
ar_f
unct
ion
PKD2
6.75
338
142
5
SLC23A2
6.75
338
142
5
XYLT1
6.75
338
142
5
SLC23A2
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
16
31
4
G
O:
00
32
81
0
G
O:
00
16
42
2
G
O:
00
04
33
5
G
O:
00
15
phosphatidylinositol-3,4,5-trisphosphate 3phosphatase activity
mol
ecul
ar_f
unct
ion
sterol response element binding
mol
ecul
ar_f
unct
ion
mRNA (2-O-methyladenosine-N6-)methyltransferase activity
mol
ecul
ar_f
unct
ion
galactokinase activity
mol
ecul
ar_f
unct
ion
potassium:hydrogen antiporter activity
mol
ecul
ar_f
unct
PTEN
6.75
338
142
5
NR1H3
6.75
338
142
5
METTL3
6.75
338
142
5
GALK2
6.75
338
142
5
SLC9A8
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
38
6
G
O:
00
30
14
4
G
O:
00
04
81
7
G
O:
00
70
89
0
G
O:
00
17
05
7
ion
alpha-1,6-mannosylglycoprotein 6-beta-Nacetylglucosaminyltransferase activity
mol
ecul
ar_f
unct
ion
cysteine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
sodium-dependent L-ascorbate
transmembrane transporter activity
mol
ecul
ar_f
unct
ion
6-phosphogluconolactonase activity
mol
ecul
ar_f
unct
ion
MGAT5
6.75
338
142
5
CARS2
6.75
338
142
5
SLC23A2
6.75
338
142
5
H6PD
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
04
34
5
glucose-6-phosphate dehydrogenase
activity
mol
ecul
ar_f
unct
ion
transforming growth factor beta receptor,
inhibitory cytoplasmic mediator activity
mol
ecul
ar_f
unct
ion
succinate dehydrogenase (ubiquinone)
activity
mol
ecul
ar_f
unct
ion
G
O:
00
04
36
5
glyceraldehyde-3-phosphate
dehydrogenase (NAD+) (phosphorylating)
activity
mol
ecul
ar_f
unct
ion
G
O:
00
35
protein-arginine omega-N symmetric
methyltransferase activity
mol
ecul
ar_f
unct
G
O:
00
30
61
7
G
O:
00
08
17
7
H6PD
6.75
338
142
5
SMAD7
6.75
338
142
5
SDHA
6.75
338
142
5
GAPDH
6.75
338
142
5
PRMT5
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
24
3
G
O:
00
04
92
3
G
O:
00
04
32
5
G
O:
00
09
04
1
G
O:
00
15
09
9
ion
leukemia inhibitory factor receptor activity
mol
ecul
ar_f
unct
ion
ferrochelatase activity
mol
ecul
ar_f
unct
ion
uridylate kinase activity
mol
ecul
ar_f
unct
ion
nickel cation transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
LIFR
6.75
338
142
5
FECH
6.75
338
142
5
CMPK2
6.75
338
142
5
SLC11A2
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
70
18
2
G
O:
00
70
73
6
G
O:
00
15
08
7
G
O:
00
45
50
5
G
O:
00
30
DNA polymerase binding
mol
ecul
ar_f
unct
ion
protein-glycine ligase activity, initiating
mol
ecul
ar_f
unct
ion
cobalt ion transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
dynein intermediate chain binding
mol
ecul
ar_f
unct
ion
kininogen binding
mol
ecul
ar_f
unct
ACD
6.75
338
142
5
TTLL3
6.75
338
142
5
SLC11A2
6.75
338
142
5
PAFAH1B1
6.75
338
142
5
CTSH
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
98
4
G
O:
00
04
92
0
G
O:
00
04
37
2
G
O:
00
05
47
1
G
O:
00
05
01
9
ion
interleukin-10 receptor activity
mol
ecul
ar_f
unct
ion
glycine hydroxymethyltransferase activity
mol
ecul
ar_f
unct
ion
ATP:ADP antiporter activity
mol
ecul
ar_f
unct
ion
platelet-derived growth factor beta-receptor
activity
mol
ecul
ar_f
unct
ion
IL10RA
6.75
338
142
5
SHMT2
6.75
338
142
5
SLC25A6
6.75
338
142
5
PDGFRB
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
01
63
5
calcitonin gene-related polypeptide receptor
activity
mol
ecul
ar_f
unct
ion
SUMO activating enzyme activity
mol
ecul
ar_f
unct
ion
Fc-gamma receptor I complex binding
mol
ecul
ar_f
unct
ion
G
O:
00
04
45
0
isocitrate dehydrogenase (NADP+) activity
mol
ecul
ar_f
unct
ion
G
O:
00
04
thyroid-stimulating hormone receptor
activity
mol
ecul
ar_f
unct
G
O:
00
19
94
8
G
O:
00
34
98
8
CRCP
6.75
338
142
5
UBA2
6.75
338
142
5
FLNA
6.75
338
142
5
IDH1
6.75
338
142
5
PAX8
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
99
6
G
O:
00
04
16
1
G
O:
00
31
72
0
G
O:
00
04
79
3
G
O:
00
42
32
8
ion
dimethylallyltranstransferase activity
mol
ecul
ar_f
unct
ion
haptoglobin binding
mol
ecul
ar_f
unct
ion
threonine aldolase activity
mol
ecul
ar_f
unct
ion
heparan sulfate Nacetylglucosaminyltransferase activity
mol
ecul
ar_f
unct
ion
FDPS
6.75
338
142
5
HBB
6.75
338
142
5
SHMT2
6.75
338
142
5
EXT1
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
09
38
4
N-acylmannosamine kinase activity
mol
ecul
ar_f
unct
ion
dITP diphosphatase activity
mol
ecul
ar_f
unct
ion
choline kinase activity
mol
ecul
ar_f
unct
ion
G
O:
00
08
52
3
sodium-dependent multivitamin
transmembrane transporter activity
mol
ecul
ar_f
unct
ion
G
O:
00
05
macrophage colony-stimulating factor
receptor activity
mol
ecul
ar_f
unct
G
O:
00
35
87
0
G
O:
00
04
10
3
NAGK
6.75
338
142
5
ITPA
6.75
338
142
5
CHKB
6.75
338
142
5
SLC23A2
6.75
338
142
5
CSF1R
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
01
1
G
O:
00
04
82
3
G
O:
00
50
50
9
G
O:
00
04
66
0
G
O:
00
00
77
4
ion
leucine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
N-acetylglucosaminyl-proteoglycan 4-betaglucuronosyltransferase activity
mol
ecul
ar_f
unct
ion
protein farnesyltransferase activity
mol
ecul
ar_f
unct
ion
adenyl-nucleotide exchange factor activity
mol
ecul
ar_f
unct
ion
LARS
6.75
338
142
5
EXT1
6.75
338
142
5
FNTB
6.75
338
142
5
GRPEL2
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
33
86
2
G
O:
00
00
15
6
G
O:
00
04
79
5
G
O:
00
70
36
3
G
O:
00
47
UMP kinase activity
mol
ecul
ar_f
unct
ion
phosphorelay response regulator activity
mol
ecul
ar_f
unct
ion
threonine synthase activity
mol
ecul
ar_f
unct
ion
mitochondrial light strand promoter sense
binding
mol
ecul
ar_f
unct
ion
beta-adrenergic receptor kinase activity
mol
ecul
ar_f
unct
CMPK2
6.75
338
142
5
PDE8A
6.75
338
142
5
THNSL2
6.75
338
142
5
TFAM
6.75
338
142
5
ADRBK2
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
69
6
G
O:
00
08
26
0
G
O:
00
04
72
7
G
O:
00
08
42
8
G
O:
00
04
45
2
ion
3-oxoacid CoA-transferase activity
mol
ecul
ar_f
unct
ion
prenylated protein tyrosine phosphatase
activity
mol
ecul
ar_f
unct
ion
ribonuclease inhibitor activity
mol
ecul
ar_f
unct
ion
isopentenyl-diphosphate delta-isomerase
activity
mol
ecul
ar_f
unct
ion
OXCT1
6.75
338
142
5
PTP4A2
6.75
338
142
5
RNH1
6.75
338
142
5
IDI1
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
72
34
5
G
O:
00
04
35
9
G
O:
00
71
55
8
G
O:
00
08
24
0
G
O:
00
08
NAADP-sensitive calcium-release channel
activity
mol
ecul
ar_f
unct
ion
glutaminase activity
mol
ecul
ar_f
unct
ion
histone demethylase activity (H3-K27
specific)
mol
ecul
ar_f
unct
ion
tripeptidyl-peptidase activity
mol
ecul
ar_f
unct
ion
CoA-transferase activity
mol
ecul
ar_f
unct
TPCN2
6.75
338
142
5
GLS
6.75
338
142
5
JHDM1D
6.75
338
142
5
TPP1
6.75
338
142
5
OXCT1
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
41
0
G
O:
00
03
86
9
G
O:
00
42
61
0
G
O:
00
08
73
2
G
O:
00
31
71
4
ion
4-nitrophenylphosphatase activity
mol
ecul
ar_f
unct
ion
CD8 receptor binding
mol
ecul
ar_f
unct
ion
L-allo-threonine aldolase activity
mol
ecul
ar_f
unct
ion
C5a anaphylatoxin chemotactic receptor
binding
mol
ecul
ar_f
unct
ion
EPHX2
6.75
338
142
5
FYN
6.75
338
142
5
SHMT2
6.75
338
142
5
C3
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
04
81
6
asparagine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
Atg12 ligase activity
mol
ecul
ar_f
unct
ion
MAP kinase activity involved in innate
immune response
mol
ecul
ar_f
unct
ion
G
O:
00
04
57
2
mannosyl-oligosaccharide 1,3-1,6-alphamannosidase activity
mol
ecul
ar_f
unct
ion
G
O:
00
35
histone demethylase activity (H4-K20
specific)
mol
ecul
ar_f
unct
G
O:
00
19
77
7
G
O:
00
38
07
5
NARS
6.75
338
142
5
ATG3
6.75
338
142
5
ADAM8
6.75
338
142
5
MAN2A2
6.75
338
142
5
JHDM1D
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
57
5
G
O:
00
51
74
7
G
O:
00
71
98
7
G
O:
00
42
83
5
G
O:
00
00
34
0
ion
cytosine C-5 DNA demethylase activity
mol
ecul
ar_f
unct
ion
WD40-repeat domain binding
mol
ecul
ar_f
unct
ion
BRE binding
mol
ecul
ar_f
unct
ion
RNA 7-methylguanosine cap binding
mol
ecul
ar_f
unct
ion
ALKBH3
6.75
338
142
5
USP47
6.75
338
142
5
CELF1
6.75
338
142
5
NCBP2
6.75
338
142
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
08
17
6
G
O:
00
04
83
2
G
O:
00
46
40
3
G
O:
00
47
75
0
G
O:
00
04
tRNA (guanine-N7-)-methyltransferase
activity
mol
ecul
ar_f
unct
ion
valine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
polynucleotide 3-phosphatase activity
mol
ecul
ar_f
unct
ion
cholestenol delta-isomerase activity
mol
ecul
ar_f
unct
ion
geranyltranstransferase activity
mol
ecul
ar_f
unct
WDR4
6.75
338
142
5
VARS
6.75
338
142
5
PNKP
6.75
338
142
5
EBPL
6.75
338
142
5
FDPS
6.75
338
142
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
33
7
G
O:
20
01
25
2
G
O:
00
42
61
1
G
O:
00
30
28
6
G
O:
20
00
41
0
ion
positive regulation of chromosome
organization
biol
ogic
al_p RPS6KA5,NIPBL,NCOR1,WDR61,PHF1,PHF19
roce
ss
1.68
407
906
2
MHC protein complex
cell
ular
_co HLA-DPB1,HLA-C,HLA-DQA1,HLA-DMB,HLA-F
mpo
nent
1.79
401
638
1
dynein complex
cell
ular
_co HDAC6,DYNC1I1,DNALI1,DNHD1,DYNC1I2
mpo
nent
1.79
401
638
1
regulation of thymocyte migration
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
43
98
8
G
O:
00
02
71
3
G
O:
00
21
77
5
G
O:
00
33
38
4
G
O:
00
35
histone H3-S28 phosphorylation
biol
ogic
al_p RPS6KA5
roce
ss
6.73
631
624
7
negative regulation of B cell mediated
immunity
biol
ogic
al_p PTPN6
roce
ss
6.73
631
624
7
smoothened signaling pathway involved in
ventral spinal cord interneuron specification
biol
ogic
al_p GLI3
roce
ss
6.73
631
624
7
geranyl diphosphate biosynthetic process
biol
ogic
al_p FDPS
roce
ss
6.73
631
624
7
external genitalia morphogenesis
biol
ogic
NIPBL
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
26
1
G
O:
00
70
90
4
G
O:
00
21
77
6
G
O:
00
45
01
3
G
O:
00
51
08
1
ss
transepithelial L-ascorbic acid transport
biol
ogic
al_p SLC23A2
roce
ss
6.73
631
624
7
smoothened signaling pathway involved in
spinal cord motor neuron cell fate
specification
biol
ogic
al_p GLI3
roce
ss
6.73
631
624
7
carbon catabolite repression of transcription
biol
ogic
al_p CHMP1A
roce
ss
6.73
631
624
7
nuclear envelope disassembly
biol
ogic
al_p PAFAH1B1
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
46
73
0
induction of host immune response by virus
biol
ogic
al_p SLC25A6
roce
ss
6.73
631
624
7
G
O:
00
32
37
7
regulation of intracellular lipid transport
biol
ogic
al_p ABCA2
roce
ss
6.73
631
624
7
G
O:
00
21
81
6
extension of a leading process involved in
cell motility in cerebral cortex radial glia
guided migration
biol
ogic
al_p SRGAP2
roce
ss
6.73
631
624
7
negative regulation of centriole replication
biol
ogic
al_p CDK5RAP2
roce
ss
6.73
631
624
7
regulation of intracellular sterol transport
biol
ogic
ABCA2
al_p
roce
6.73
631
624
7
G
O:
00
46
60
0
G
O:
00
32
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
38
0
G
O:
00
90
03
5
G
O:
00
35
55
2
G
O:
00
48
37
8
G
O:
00
15
88
2
ss
positive regulation of chaperone-mediated
protein complex assembly
biol
ogic
al_p HDAC6
roce
ss
6.73
631
624
7
oxidative single-stranded DNA
demethylation
biol
ogic
al_p ALKBH3
roce
ss
6.73
631
624
7
regulation of lateral mesodermal cell fate
specification
biol
ogic
al_p FGFR1
roce
ss
6.73
631
624
7
L-ascorbic acid transport
biol
ogic
al_p SLC23A2
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
71
89
5
G
O:
19
00
22
0
G
O:
00
72
00
4
G
O:
00
32
38
3
G
O:
00
70
odontoblast differentiation
biol
ogic
al_p LEF1
roce
ss
6.73
631
624
7
semaphorin-plexin signaling pathway
involved in bone trabecula morphogenesis
biol
ogic
al_p SEMA4D
roce
ss
6.73
631
624
7
kidney field specification
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
regulation of intracellular cholesterol
transport
biol
ogic
al_p ABCA2
roce
ss
6.73
631
624
7
polyubiquitinated protein transport
biol
ogic
HDAC6
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
84
4
G
O:
00
97
06
2
G
O:
00
34
49
9
G
O:
00
71
55
7
G
O:
00
38
16
2
ss
dendritic spine maintenance
biol
ogic
al_p TANC1
roce
ss
6.73
631
624
7
late endosome to Golgi transport
biol
ogic
al_p GCC2
roce
ss
6.73
631
624
7
histone H3-K27 demethylation
biol
ogic
al_p JHDM1D
roce
ss
6.73
631
624
7
erythropoietin-mediated signaling pathway
biol
ogic
al_p EPOR
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
20
00
68
0
regulation of rubidium ion transport
biol
ogic
al_p CD63
roce
ss
6.73
631
624
7
valyl-tRNA aminoacylation
biol
ogic
al_p VARS
roce
ss
6.73
631
624
7
non-lytic virus budding
biol
ogic
al_p TSG101
roce
ss
6.73
631
624
7
G
O:
00
06
01
4
D-ribose metabolic process
biol
ogic
al_p RBKS
roce
ss
6.73
631
624
7
G
O:
19
00
apoptotic process involved in metanephric
nephron tubule development
biol
ogic
PAX8
al_p
roce
6.73
631
624
7
G
O:
00
06
43
8
G
O:
00
46
75
5
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
20
5
G
O:
00
35
42
0
G
O:
00
90
18
2
G
O:
00
06
40
8
G
O:
00
15
96
6
ss
MAPK cascade involved in innate immune
response
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
regulation of secretion of lysosomal
enzymes
biol
ogic
al_p NR1H3
roce
ss
6.73
631
624
7
snRNA export from nucleus
biol
ogic
al_p NCBP2
roce
ss
6.73
631
624
7
diadenosine tetraphosphate biosynthetic
process
biol
ogic
al_p GARS
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
10
99
9
regulation of eIF2 alpha phosphorylation by
heme
biol
ogic
al_p FECH
roce
ss
6.73
631
624
7
negative regulation of type B pancreatic cell
development
biol
ogic
al_p GSK3A
roce
ss
6.73
631
624
7
regulation of progesterone secretion
biol
ogic
al_p RUNX1
roce
ss
6.73
631
624
7
G
O:
00
21
78
5
branchiomotor neuron axon guidance
biol
ogic
al_p MYCBP2
roce
ss
6.73
631
624
7
G
O:
00
71
negative regulation of estrogen receptor
binding
biol
ogic
LEF1
al_p
roce
6.73
631
624
7
G
O:
20
00
07
7
G
O:
20
00
87
0
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
89
9
G
O:
00
03
22
1
G
O:
00
06
05
1
G
O:
00
55
02
2
G
O:
00
15
96
5
ss
right ventricular cardiac muscle tissue
morphogenesis
biol
ogic
al_p ZFPM2
roce
ss
6.73
631
624
7
N-acetylmannosamine metabolic process
biol
ogic
al_p NAGK
roce
ss
6.73
631
624
7
negative regulation of cardiac muscle tissue
growth
biol
ogic
al_p GSK3A
roce
ss
6.73
631
624
7
diadenosine tetraphosphate metabolic
process
biol
ogic
al_p GARS
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
34
69
9
G
O:
00
43
00
0
G
O:
00
06
42
9
G
O:
00
72
36
4
G
O:
00
42
response to luteinizing hormone stimulus
biol
ogic
al_p TGFBR3
roce
ss
6.73
631
624
7
Golgi to plasma membrane CFTR protein
transport
biol
ogic
al_p GOPC
roce
ss
6.73
631
624
7
leucyl-tRNA aminoacylation
biol
ogic
al_p LARS
roce
ss
6.73
631
624
7
regulation of cellular ketone metabolic
process by regulation of transcription from
RNA polymerase II promoter
biol
ogic
al_p NCOR2
roce
ss
6.73
631
624
7
GDP-L-fucose biosynthetic process
biol
ogic
GMDS
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
35
0
G
O:
00
09
08
8
ss
threonine biosynthetic process
biol
ogic
al_p THNSL2
roce
ss
6.73
631
624
7
G
O:
20
00
16
7
regulation of planar cell polarity pathway
involved in neural tube closure
biol
ogic
al_p NPHP3
roce
ss
6.73
631
624
7
G
O:
19
00
21
1
regulation of mesenchymal cell apoptotic
process involved in metanephros
development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
response to vitamin B1
biol
ogic
al_p MDM2
roce
ss
6.73
631
624
7
G
O:
00
10
26
6
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
46
60
6
G
O:
00
02
03
6
G
O:
00
71
87
9
G
O:
00
61
08
6
G
O:
00
42
negative regulation of centrosome cycle
biol
ogic
al_p CDK5RAP2
roce
ss
regulation of L-glutamate transport
biol
ogic
al_p
roce
ss
positive regulation of adrenergic receptor
signaling pathway
biol
ogic
al_p GSK3A
roce
ss
6.73
631
624
7
negative regulation of histone H3-K27
methylation
biol
ogic
al_p PHF1
roce
ss
6.73
631
624
7
de novo GDP-L-fucose biosynthetic process
biol
ogic
GMDS
al_p
roce
6.73
631
624
7
6.73
631
624
7
6.73
631
2-Sep
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
35
1
G
O:
00
35
57
4
ss
histone H4-K20 demethylation
biol
ogic
al_p JHDM1D
roce
ss
6.73
631
624
7
purine ribonucleoside diphosphate
biosynthetic process
biol
ogic
al_p AK5
roce
ss
6.73
631
624
7
G
O:
19
00
21
4
regulation of apoptotic process involved in
metanephric collecting duct development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
G
O:
00
21
81
5
modulation of microtubule cytoskeleton
involved in cerebral cortex radial glia guided
migration
biol
ogic
al_p SRGAP2
roce
ss
6.73
631
624
7
G
O:
00
09
18
0
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
20
00
41
2
positive regulation of thymocyte migration
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
cellular response to hydrostatic pressure
biol
ogic
al_p PKD2
roce
ss
6.73
631
624
7
purine deoxyribonucleotide biosynthetic
process
biol
ogic
al_p AK5
roce
ss
6.73
631
624
7
G
O:
00
46
36
8
GDP-L-fucose metabolic process
biol
ogic
al_p GMDS
roce
ss
6.73
631
624
7
G
O:
00
08
maternal determination of anterior/posterior
axis, embryo
biol
ogic
PLD6
al_p
roce
6.73
631
624
7
G
O:
00
71
46
4
G
O:
00
09
15
3
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
35
8
G
O:
00
33
27
8
G
O:
00
48
37
7
G
O:
00
51
93
3
G
O:
00
48
21
0
ss
cell proliferation in midbrain
biol
ogic
al_p FZD6
roce
ss
6.73
631
624
7
lateral mesodermal cell fate specification
biol
ogic
al_p FGFR1
roce
ss
6.73
631
624
7
amino acid uptake involved in synaptic
transmission
biol
ogic
al_p CLN8
roce
ss
6.73
631
624
7
Golgi vesicle fusion to target membrane
biol
ogic
al_p RAB8A
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
15
96
0
G
O:
00
42
23
1
G
O:
00
45
01
4
G
O:
00
46
73
2
G
O:
20
01
diadenosine polyphosphate biosynthetic
process
biol
ogic
al_p GARS
roce
ss
6.73
631
624
7
interleukin-13 biosynthetic process
biol
ogic
al_p IL18
roce
ss
6.73
631
624
7
negative regulation of transcription by
glucose
biol
ogic
al_p CHMP1A
roce
ss
6.73
631
624
7
active induction of host immune response
by virus
biol
ogic
al_p SLC25A6
roce
ss
6.73
631
624
7
regulation of histone H3-K79 methylation
biol
ogic
WDR61
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
16
0
G
O:
00
71
34
4
ss
diphosphate metabolic process
biol
ogic
al_p PPA2
roce
ss
6.73
631
624
7
metanephric smooth muscle tissue
development
biol
ogic
al_p PKD2
roce
ss
6.73
631
624
7
G
O:
00
08
61
5
pyridoxine biosynthetic process
biol
ogic
al_p PNPO
roce
ss
6.73
631
624
7
G
O:
00
72
36
1
regulation of glycolysis by regulation of
transcription from RNA polymerase II
promoter
biol
ogic
al_p NCOR1
roce
ss
6.73
631
624
7
G
O:
00
72
20
8
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
15
99
3
molecular hydrogen transport
biol
ogic
al_p SLC23A2
roce
ss
6.73
631
624
7
positive regulation of histone H3-K79
methylation
biol
ogic
al_p WDR61
roce
ss
6.73
631
624
7
oocyte axis specification
biol
ogic
al_p PLD6
roce
ss
6.73
631
624
7
G
O:
00
71
39
4
cellular response to testosterone stimulus
biol
ogic
al_p AACS
roce
ss
6.73
631
624
7
G
O:
20
00
regulation of metanephric DCT cell
differentiation
biol
ogic
PAX8
al_p
roce
6.73
631
624
7
G
O:
20
01
16
2
G
O:
00
07
30
9
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
59
2
G
O:
00
03
17
2
G
O:
19
00
21
8
G
O:
00
71
86
6
G
O:
00
97
10
7
ss
sinoatrial valve development
biol
ogic
al_p MEF2A
roce
ss
6.73
631
624
7
negative regulation of apoptotic process
involved in metanephric nephron tubule
development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
negative regulation of apoptotic process in
bone marrow
biol
ogic
al_p LEF1
roce
ss
6.73
631
624
7
postsynaptic density assembly
biol
ogic
al_p PTEN
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
46
83
3
G
O:
00
97
10
6
G
O:
00
43
98
7
G
O:
00
31
02
2
G
O:
00
21
positive regulation of RNA export from
nucleus
biol
ogic
al_p NCBP2
roce
ss
6.73
631
624
7
postsynaptic density organization
biol
ogic
al_p PTEN
roce
ss
6.73
631
624
7
histone H3-S10 phosphorylation
biol
ogic
al_p RPS6KA5
roce
ss
6.73
631
624
7
nuclear migration along microfilament
biol
ogic
al_p SUN2
roce
ss
6.73
631
624
7
neural plate axis specification
biol
ogic
C2CD3
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
99
7
G
O:
20
00
32
7
G
O:
00
30
39
7
G
O:
00
34
72
9
G
O:
00
06
52
9
ss
positive regulation of ligand-dependent
nuclear receptor transcription coactivator
activity
biol
ogic
al_p RQCD1
roce
ss
6.73
631
624
7
membrane disassembly
biol
ogic
al_p PAFAH1B1
roce
ss
6.73
631
624
7
histone H3-K79 methylation
biol
ogic
al_p WDR61
roce
ss
6.73
631
624
7
asparagine biosynthetic process
biol
ogic
al_p ASNS
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
50
99
2
dimethylallyl diphosphate biosynthetic
process
biol
ogic
al_p IDI1
roce
ss
6.73
631
624
7
negative regulation of mast cell cytokine
production
biol
ogic
al_p BCL6
roce
ss
6.73
631
624
7
regulation of kinetochore assembly
biol
ogic
al_p SENP6
roce
ss
6.73
631
624
7
G
O:
00
48
93
6
peripheral nervous system neuron
axonogenesis
biol
ogic
al_p TBCE
roce
ss
6.73
631
624
7
G
O:
00
30
negative regulation of nucleotide catabolic
process
biol
ogic
GSK3A
al_p
roce
6.73
631
624
7
G
O:
00
32
76
4
G
O:
00
90
23
4
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
81
2
G
O:
00
08
61
4
G
O:
00
07
31
5
G
O:
00
15
67
5
G
O:
00
34
20
5
ss
pyridoxine metabolic process
biol
ogic
al_p PNPO
roce
ss
6.73
631
624
7
pole plasm assembly
biol
ogic
al_p PLD6
roce
ss
6.73
631
624
7
nickel cation transport
biol
ogic
al_p SLC11A2
roce
ss
6.73
631
624
7
beta-amyloid formation
biol
ogic
al_p FKBP1A
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
06
74
1
G
O:
19
00
21
2
G
O:
00
07
31
4
G
O:
00
39
01
7
G
O:
00
35
NADP biosynthetic process
biol
ogic
al_p NADK
roce
ss
6.73
631
624
7
negative regulation of mesenchymal cell
apoptotic process involved in metanephros
development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
oocyte anterior/posterior axis specification
biol
ogic
al_p PLD6
roce
ss
6.73
631
624
7
pattern specification involved in pronephros
development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
aortic smooth muscle cell differentiation
biol
ogic
SMARCA4
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
88
7
G
O:
00
32
86
1
G
O:
00
34
19
6
G
O:
00
07
30
8
G
O:
20
01
17
0
ss
activation of Rap GTPase activity
biol
ogic
al_p SIPA1L1
roce
ss
6.73
631
624
7
acylglycerol transport
biol
ogic
al_p VAMP7
roce
ss
6.73
631
624
7
oocyte construction
biol
ogic
al_p PLD6
roce
ss
6.73
631
624
7
negative regulation of ATP biosynthetic
process
biol
ogic
al_p FLCN
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
30
07
0
G
O:
00
70
16
5
G
O:
00
21
76
9
G
O:
00
44
41
6
G
O:
00
19
insulin processing
biol
ogic
al_p CPE
roce
ss
6.73
631
624
7
positive regulation of adiponectin secretion
biol
ogic
al_p C1QTNF3
roce
ss
6.73
631
624
7
orbitofrontal cortex development
biol
ogic
al_p FGFR1
roce
ss
6.73
631
624
7
induction by symbiont of host defense
response
biol
ogic
al_p SLC25A6
roce
ss
6.73
631
624
7
glycine biosynthetic process from serine
biol
ogic
SHMT2
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
26
4
G
O:
00
19
30
3
G
O:
00
09
13
6
G
O:
19
00
67
3
G
O:
00
30
71
9
ss
D-ribose catabolic process
biol
ogic
al_p RBKS
roce
ss
6.73
631
624
7
purine nucleoside diphosphate biosynthetic
process
biol
ogic
al_p AK5
roce
ss
6.73
631
624
7
olefin metabolic process
biol
ogic
al_p EPHX2
roce
ss
6.73
631
624
7
P granule organization
biol
ogic
al_p PLD6
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
46
75
3
G
O:
00
21
94
3
G
O:
00
35
98
4
G
O:
00
70
84
3
G
O:
20
00
non-lytic viral release
biol
ogic
al_p TSG101
roce
ss
6.73
631
624
7
formation of radial glial scaffolds
biol
ogic
al_p LEF1
roce
ss
6.73
631
624
7
cellular response to trichostatin A
biol
ogic
al_p MEF2A
roce
ss
6.73
631
624
7
misfolded protein transport
biol
ogic
al_p HDAC6
roce
ss
6.73
631
624
7
regulation of CD40 signaling pathway
biol
ogic
SHARPIN
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
34
8
G
O:
00
31
17
9
ss
peptide modification
biol
ogic
al_p PAM
roce
ss
6.73
631
624
7
macrophage colony-stimulating factor
signaling pathway
biol
ogic
al_p CSF1R
roce
ss
6.73
631
624
7
G
O:
20
01
24
5
regulation of phosphatidylcholine
biosynthetic process
biol
ogic
al_p LPCAT1
roce
ss
6.73
631
624
7
G
O:
00
72
30
4
regulation of mesenchymal cell apoptotic
process involved in metanephric nephron
morphogenesis
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
G
O:
00
38
14
5
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
02
29
6
G
O:
00
71
83
9
G
O:
00
01
51
9
G
O:
00
48
55
0
G
O:
00
70
T-helper 1 cell lineage commitment
biol
ogic
al_p STAT6
roce
ss
6.73
631
624
7
apoptotic process in bone marrow
biol
ogic
al_p LEF1
roce
ss
6.73
631
624
7
peptide amidation
biol
ogic
al_p PAM
roce
ss
6.73
631
624
7
negative regulation of pinocytosis
biol
ogic
al_p NR1H3
roce
ss
6.73
631
624
7
detection of hypoxia
biol
ogic
ENG
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
48
3
G
O:
00
71
16
7
G
O:
19
00
20
4
G
O:
00
60
69
0
G
O:
00
06
09
7
ss
ribonucleoprotein complex import into
nucleus
biol
ogic
al_p TGS1
roce
ss
6.73
631
624
7
apoptotic process involved in metanephric
collecting duct development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
epithelial cell differentiation involved in
salivary gland development
biol
ogic
al_p XBP1
roce
ss
6.73
631
624
7
glyoxylate cycle
biol
ogic
al_p IDH1
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
06
22
7
G
O:
00
31
13
4
G
O:
00
71
89
8
G
O:
00
32
29
8
G
O:
00
39
dUDP biosynthetic process
biol
ogic
al_p CMPK2
roce
ss
6.73
631
624
7
sister chromatid biorientation
biol
ogic
al_p RB1
roce
ss
6.73
631
624
7
regulation of estrogen receptor binding
biol
ogic
al_p LEF1
roce
ss
6.73
631
624
7
positive regulation of DNA-dependent DNA
replication initiation
biol
ogic
al_p CIZ1
roce
ss
6.73
631
624
7
pronephric field specification
biol
ogic
PAX8
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
00
3
G
O:
00
71
86
5
G
O:
00
48
07
3
G
O:
00
03
12
7
G
O:
00
10
81
3
ss
regulation of apoptotic process in bone
marrow
biol
ogic
al_p LEF1
roce
ss
6.73
631
624
7
regulation of eye pigmentation
biol
ogic
al_p HPS4
roce
ss
6.73
631
624
7
detection of nodal flow
biol
ogic
al_p PKD2
roce
ss
6.73
631
624
7
neuropeptide catabolic process
biol
ogic
al_p CTSH
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
19
00
73
6
G
O:
20
00
30
9
G
O:
19
00
21
7
G
O:
00
30
38
2
G
O:
00
70
regulation of phospholipase C-activating Gprotein coupled receptor signaling pathway
biol
ogic
al_p BICD1
roce
ss
6.73
631
624
7
positive regulation of tumor necrosis factor
(ligand) superfamily member 11 production
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
regulation of apoptotic process involved in
metanephric nephron tubule development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
sperm mitochondrion organization
biol
ogic
al_p
roce
ss
mitochondrial tRNA modification
biol
ogic
MTO1
al_p
roce
6.73
631
4-Sep
624
7
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
90
0
G
O:
00
45
06
5
G
O:
00
72
67
9
G
O:
00
46
05
6
G
O:
20
00
25
9
ss
cytotoxic T cell differentiation
biol
ogic
al_p SART1
roce
ss
6.73
631
624
7
thymocyte migration
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
dADP metabolic process
biol
ogic
al_p AK5
roce
ss
6.73
631
624
7
positive regulation of protein activation
cascade
biol
ogic
al_p C3
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
15
68
4
ferrous iron transport
biol
ogic
al_p SLC11A2
roce
ss
6.73
631
624
7
G
O:
00
35
44
4
nickel cation transmembrane transport
biol
ogic
al_p SLC11A2
roce
ss
6.73
631
624
7
G
O:
00
72
30
5
negative regulation of mesenchymal cell
apoptotic process involved in metanephric
nephron morphogenesis
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
trigeminal nerve morphogenesis
biol
ogic
al_p NRP1
roce
ss
6.73
631
624
7
cysteinyl-tRNA aminoacylation
biol
ogic
CARS2
al_p
roce
6.73
631
624
7
G
O:
00
21
63
6
G
O:
00
06
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
42
3
G
O:
00
90
00
7
G
O:
19
00
20
0
G
O:
00
34
19
7
G
O:
20
00
50
4
ss
regulation of mitotic anaphase
biol
ogic
al_p PLK1
roce
ss
6.73
631
624
7
mesenchymal cell apoptotic process
involved in metanephros development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
triglyceride transport
biol
ogic
al_p VAMP7
roce
ss
6.73
631
624
7
positive regulation of blood vessel
remodeling
biol
ogic
al_p IL18
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
09
18
2
G
O:
00
46
60
7
G
O:
00
60
30
0
G
O:
00
46
77
8
G
O:
00
19
purine deoxyribonucleoside diphosphate
metabolic process
biol
ogic
al_p AK5
roce
ss
6.73
631
624
7
positive regulation of centrosome cycle
biol
ogic
al_p RANBP1
roce
ss
6.73
631
624
7
regulation of cytokine activity
biol
ogic
al_p NRP1
roce
ss
6.73
631
624
7
modification by virus of host mRNA
processing
biol
ogic
al_p PABPN1
roce
ss
6.73
631
624
7
late viral mRNA transcription
biol
ogic
USF1
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
08
6
G
O:
00
02
89
0
G
O:
00
48
37
2
G
O:
19
01
21
9
G
O:
19
00
86
4
ss
negative regulation of immunoglobulin
mediated immune response
biol
ogic
al_p PTPN6
roce
ss
6.73
631
624
7
lateral mesodermal cell fate commitment
biol
ogic
al_p FGFR1
roce
ss
6.73
631
624
7
regulation of cardiac chamber
morphogenesis
biol
ogic
al_p TBX2
roce
ss
6.73
631
624
7
mitochondrial RNA modification
biol
ogic
al_p MTO1
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
70
52
5
G
O:
00
61
05
2
G
O:
20
00
41
6
G
O:
00
03
13
8
G
O:
00
35
threonylcarbamoyladenosine metabolic
process
biol
ogic
al_p MTO1
roce
ss
6.73
631
624
7
negative regulation of cell growth involved
in cardiac muscle cell development
biol
ogic
al_p GSK3A
roce
ss
6.73
631
624
7
regulation of eosinophil migration
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
primary heart field specification
biol
ogic
al_p MEF2A
roce
ss
6.73
631
624
7
rubidium ion transport
biol
ogic
CD63
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
82
6
G
O:
00
35
41
9
G
O:
00
02
63
5
G
O:
00
36
11
2
G
O:
00
01
97
0
ss
activation of MAPK activity involved in
innate immune response
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
negative regulation of germinal center
formation
biol
ogic
al_p RC3H1
roce
ss
6.73
631
624
7
medium-chain fatty-acyl-CoA metabolic
process
biol
ogic
al_p HSD17B4
roce
ss
6.73
631
624
7
positive regulation of activation of
membrane attack complex
biol
ogic
al_p C3
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
35
60
7
G
O:
19
00
21
5
fibroblast growth factor receptor signaling
pathway involved in orbitofrontal cortex
development
biol
ogic
al_p FGFR1
roce
ss
6.73
631
624
7
negative regulation of apoptotic process
involved in metanephric collecting duct
development
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
farnesyl diphosphate biosynthetic process
biol
ogic
al_p FDPS
roce
ss
6.73
631
624
7
G
O:
00
72
36
8
regulation of lipid transport by negative
regulation of transcription from RNA
polymerase II promoter
biol
ogic
al_p NCOR1
roce
ss
6.73
631
624
7
G
O:
20
00
positive regulation of hematopoietic stem
cell migration
biol
ogic
PTPRC
al_p
roce
6.73
631
624
7
G
O:
00
45
33
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
47
3
G
O:
00
72
53
5
G
O:
00
97
28
6
G
O:
00
50
99
3
G
O:
00
60
41
4
ss
tumor necrosis factor (ligand) superfamily
member 11 production
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
iron ion import
biol
ogic
al_p SLC11A2
roce
ss
6.73
631
624
7
dimethylallyl diphosphate metabolic process
biol
ogic
al_p IDI1
roce
ss
6.73
631
624
7
aorta smooth muscle tissue morphogenesis
biol
ogic
al_p MYLK
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
01
30
0
G
O:
00
06
05
0
G
O:
00
30
04
7
G
O:
20
00
59
4
G
O:
00
00
chronological cell aging
biol
ogic
al_p ENG
roce
ss
6.73
631
624
7
mannosamine metabolic process
biol
ogic
al_p NAGK
roce
ss
6.73
631
624
7
actin modification
biol
ogic
al_p TWF1
roce
ss
6.73
631
624
7
positive regulation of metanephric DCT cell
differentiation
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
protein import into nucleus, docking
biol
ogic
NUP98
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
05
9
G
O:
00
00
35
4
G
O:
00
60
02
5
G
O:
00
72
13
4
G
O:
00
70
81
6
ss
cis assembly of pre-catalytic spliceosome
biol
ogic
al_p DDX23
roce
ss
6.73
631
624
7
regulation of synaptic activity
biol
ogic
al_p MEF2A
roce
ss
6.73
631
624
7
nephrogenic mesenchyme morphogenesis
biol
ogic
al_p SMAD4
roce
ss
6.73
631
624
7
phosphorylation of RNA polymerase II Cterminal domain
biol
ogic
al_p CDK13
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
50
92
5
G
O:
00
46
07
7
G
O:
00
21
52
6
G
O:
00
72
30
9
G
O:
00
42
negative regulation of negative chemotaxis
biol
ogic
al_p ROBO2
roce
ss
6.73
631
624
7
dUDP metabolic process
biol
ogic
al_p CMPK2
roce
ss
6.73
631
624
7
medial motor column neuron differentiation
biol
ogic
al_p LHX4
roce
ss
6.73
631
624
7
mesenchymal stem cell maintenance
involved in metanephric nephron
morphogenesis
biol
ogic
al_p PAX8
roce
ss
6.73
631
624
7
vitamin B6 biosynthetic process
biol
ogic
PNPO
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
81
9
G
O:
00
45
91
7
ss
positive regulation of complement activation
biol
ogic
al_p C3
roce
ss
6.73
631
624
7
G
O:
00
70
84
5
polyubiquitinated misfolded protein
transport
biol
ogic
al_p HDAC6
roce
ss
6.73
631
624
7
G
O:
00
60
82
3
canonical Wnt receptor signaling pathway
involved in neural plate anterior/posterior
pattern formation
biol
ogic
al_p TBX18
roce
ss
6.73
631
624
7
negative regulation of triglyceride
biosynthetic process
biol
ogic
al_p FBXW7
roce
ss
6.73
631
624
7
G
O:
00
10
86
8
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
72
15
6
G
O:
00
35
98
3
G
O:
00
72
23
7
G
O:
00
06
34
8
G
O:
00
48
distal tubule morphogenesis
biol
ogic
al_p PKD1
roce
ss
6.73
631
624
7
response to trichostatin A
biol
ogic
al_p MEF2A
roce
ss
6.73
631
624
7
metanephric proximal tubule development
biol
ogic
al_p PKD1
roce
ss
6.73
631
624
7
chromatin silencing at telomere
biol
ogic
al_p SIRT2
roce
ss
6.73
631
624
7
compound eye development
biol
ogic
CTNS
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
74
9
G
O:
00
35
61
7
G
O:
00
33
26
2
G
O:
00
33
38
3
G
O:
00
19
91
8
ss
stress granule disassembly
biol
ogic
al_p KLC1
roce
ss
6.73
631
624
7
regulation of DNA replication involved in S
phase
biol
ogic
al_p INO80
roce
ss
6.73
631
624
7
geranyl diphosphate metabolic process
biol
ogic
al_p FDPS
roce
ss
6.73
631
624
7
peptidyl-arginine methylation, to
symmetrical-dimethyl arginine
biol
ogic
al_p PRMT5
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
02
92
4
negative regulation of humoral immune
response mediated by circulating
immunoglobulin
biol
ogic
al_p PTPN6
roce
ss
6.73
631
624
7
sinoatrial valve morphogenesis
biol
ogic
al_p MEF2A
roce
ss
6.73
631
624
7
eosinophil fate commitment
biol
ogic
al_p GATA2
roce
ss
6.73
631
624
7
G
O:
00
51
93
5
L-glutamate uptake involved in synaptic
transmission
biol
ogic
al_p CLN8
roce
ss
6.73
631
624
7
G
O:
19
00
negative regulation of interleukin-6
secretion
biol
ogic
C1QTNF3
al_p
roce
6.73
631
624
7
G
O:
00
03
18
5
G
O:
00
35
85
4
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
16
5
G
O:
00
90
03
4
G
O:
20
00
47
1
G
O:
20
00
30
7
G
O:
00
46
04
1
ss
regulation of chaperone-mediated protein
complex assembly
biol
ogic
al_p HDAC6
roce
ss
6.73
631
624
7
regulation of hematopoietic stem cell
migration
biol
ogic
al_p PTPRC
roce
ss
6.73
631
624
7
regulation of tumor necrosis factor (ligand)
superfamily member 11 production
biol
ogic
al_p ADAM8
roce
ss
6.73
631
624
7
ITP metabolic process
biol
ogic
al_p ITPA
roce
ss
6.73
631
624
7
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
G
O:
00
06
17
2
G
O:
00
72
07
6
G
O:
00
60
46
5
G
O:
00
10
99
8
G
O:
00
61
ADP biosynthetic process
biol
ogic
al_p AK5
roce
ss
6.73
631
624
7
nephrogenic mesenchyme development
biol
ogic
al_p SMAD4
roce
ss
6.73
631
624
7
pharynx development
biol
ogic
al_p TBX2
roce
ss
6.73
631
624
7
regulation of translational initiation by eIF2
alpha phosphorylation
biol
ogic
al_p FECH
roce
ss
6.73
631
624
7
negative regulation of heart growth
biol
ogic
GSK3A
al_p
roce
6.73
631
624
7
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
0
1
1.
4
3
E
11
7
G
O:
00
70
37
5
G
O:
00
09
89
5
G
O:
00
46
52
7
G
O:
00
05
75
8
ss
ERK5 cascade
biol
ogic
al_p MEF2A
roce
ss
6.73
631
624
7
negative regulation of catabolic process
biol
ogic
UBXN1,NPC1,TBC1D14,WAC,FYN,SMAD4,FLNA,NRBP2,GSK3A,PABP
al_p
C1
roce
ss
1.46
441
657
5
glucosyltransferase activity
mol
ecul
ar_f
unct
ion
2.25
112
714
2
mitochondrial intermembrane space
cell
ular
_co SHMT2,NLN,TIMM23,DTYMK,GOLPH3,DIABLO
mpo
nent
ALG6,GSK3A,IGF2
1.67
919
933
3
0
1
1.
4
3
E
0
1
1.
4
4
E
0
1
1.
4
4
E
0
1
1.
4
5
E
0
1
G
O:
00
72
24
3
G
O:
00
07
25
0
G
O:
00
72
23
4
G
O:
00
02
82
0
G
O:
00
01
metanephric nephron epithelium
development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
2.24
543
874
9
activation of NF-kappaB-inducing kinase
activity
biol
ogic
al_p ZFP91,CARD14,TNFRSF10B
roce
ss
2.24
543
874
9
metanephric nephron tubule development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
2.24
543
874
9
negative regulation of adaptive immune
response
biol
ogic
al_p PTPN6,RC3H1,PTPRC
roce
ss
2.24
543
874
9
negative regulation of cell-matrix adhesion
biol
ogic
BCL6,NF1,PTEN
al_p
roce
2.24
543
874
9
1.
4
5
E
0
1
1.
4
5
E
0
1
1.
4
5
E
0
1
1.
4
5
E
0
1
1.
4
5
E
95
3
G
O:
00
00
26
6
G
O:
00
32
28
8
G
O:
00
55
09
3
G
O:
19
01
22
2
ss
mitochondrial fission
biol
ogic
al_p MARCH5,DNM1L,ATG3
roce
ss
2.24
543
874
9
myelin assembly
biol
ogic
al_p CD9,PMP22,TENM4
roce
ss
2.24
543
874
9
response to hyperoxia
biol
ogic
al_p BDNF,IL18,PDGFRB
roce
ss
2.24
543
874
9
regulation of NIK/NF-kappaB cascade
biol
ogic
al_p ZFP91,CARD14,TNFRSF10B
roce
ss
2.24
543
874
9
0
1
1.
4
5
E
0
1
1.
4
5
E
0
1
1.
4
5
E
0
1
1.
4
5
E
0
1
G
O:
00
36
29
6
G
O:
00
08
20
3
G
O:
00
48
73
1
response to increased oxygen levels
biol
ogic
al_p BDNF,IL18,PDGFRB
roce
ss
2.24
543
874
9
cholesterol metabolic process
biol
ogic
ACADVL,EPHX2,FDPS,FDXR,NPC1,CLN8,IDI1,STARD3,SNX17,FECH,
al_p
LEPR,LMF1
roce
ss
1.40
583
991
2
system development
FZD6,CRIP2,EIF2B4,CADM1,RAI1,CKB,CLMN,IGF1R,LAMB1,NPHP3,P
TS,SIRT2,UTRN,RAF1,COL9A1,CDK13,BDNF,TAZ,SIN3B,CPE,PLCD1,
SART1,COL2A1,LUC7L,BCL6,TBX2,PTPN22,CNTF,CUX1,FMR1,SMAD
7,BMP8A,GLG1,ARHGEF12,RNH1,IL15RA,CD72,LEF1,PAX8,EMX2,ITG
A9,ADAMTS1,BCL2L11,MEPE,XBP1,PAM,MARK4,UHMK1,ADAM8,CD9
,SIPA1L1,KRIT1,MINK1,PDLIM5,PTPN6,ACTR3,LHX4,VASP,CSNK2A1,
ASNS,JAG2,RC3H1,CHD6,ZC3H12A,SEPT4,POLM,SLC11A2,AAMP,LS
biol
AMP,CNP,CLN8,TBX18,JHDM1D,GIGYF2,FLG,STK4,FGFR1,RAB18,HS
ogic
F4,DISP1,CAPRIN1,PAF1,TAB2,SHARPIN,RNF8,COL12A1,FKBP1A,PR
al_p
KCH,YY1,SSH2,THBS3,PFDN5,CREB1,NPTN,DFNA5,NF1,ZEB1,CRIP1
roce
,NUMA1,RGMB,COL18A1,NPR1,RPS6KA5,NIPBL,PKD2,CASP2,SLC12
ss
A6,RXRB,LMNA,MITF,ITGA3,RB1,MAPK8IP3,ZFPM2,BLOC1S5,RNF16
8,PAFAH1B1,SENP2,IL18,MTCH1,TPP1,AACS,EPN2,ADAM15,USP33,
HEXA,FLCN,NRP1,TENC1,STX2,PTEN,FYN,ALDH1A3,IDH1,RUNX2,IQ
GAP1,FBXW7,SMARCD3,IFT172,CTNS,SRGAP2,NCOR1,MEF2A,DYM,
OXCT1,TTC7A,FECH,TCTN1,CACNB1,MYCBP2,MYLK,MAN1A2,PBX3,
RAB8A,TRIM28,CSK,CDK5RAP2,COL9A3,PTPRS,PTPRC,SWAP70,IM
PDH1,UBP1,CDK6,RARRES2,WDR61,FLOT1,RANBP9,PAK1,EVC,NCK
1.05
797
838
5
1.
4
5
E
0
1
1.
4
5
E
0
1
1.
4
5
E
0
1
2,RAB10,SEMA6A,CTSH,TCF4,ACD,SEMA4D,CSF1R,C3,HSD17B4,RO
BO3,SMAD4,NAV1,TGFB1I1,DDAH1,EZR,CD276,NR2C2,FLNA,RAB5A,
GLI3,TMED2,SDCBP2,MAPK12,EPN1,ENG,TCF12,ARNT,NOX4,EXT1,
ERCC1,GAA,NRBP2,STK36,SDHA,WWP1,ARHGEF7,TBCE,UNC5B,MD
FI,PTPRD,ITGA5,LPCAT1,PDGFRB,COL8A1,LGALS8,EPOR,FARP1,R
UNX1,MKNK2,SMARCA4,KIF13B,TLN1,FGF14,CD164,GSK3A,ANKRD6
,ITGA11,NLGN2,NCOR2,FPGS,SETD2,EMP1,COL13A1,IGF2,PTGIS,M
YO1E,ATXN3,GPHN,STAT6,TANC1,ACIN1,PSD3,ROBO2,CACNB3,PM
P22,CLIC4,CDK5RAP1,BNIP2,NTRK1,SMAD9,DUSP6,CTTNBP2,TGFB
R3,ZBTB16,SEPT2,PKD1,PDPK1,TSG101,FOXC1,ACAN,STK24,SEMA
4B,SSH1,CDK5RAP3,C2CD3,WNK1,CLASP1,TENM4,GATA2,BCL2L2
G
O:
00
31
53
2
G
O:
00
00
98
9
G
O:
00
30
15
4
actin cytoskeleton reorganization
biol
ogic
al_p SIPA1L1,MINK1,CAPN10,PHPT1,PAK1,CSF1R,FLNA
roce
ss
1.59
844
792
3
transcription factor binding transcription
factor activity
mol
ecul
ar_f
unct
ion
NOC2L,SIN3B,SUPT20H,MMS19,RBPMS,HDGF,TBX18,DR1,HSF4,YY1
,GMEB2,PFDN5,CREB1,ZEB1,RXRB,RB1,ZFPM2,TP53BP1,SUB1,NR1
H3,SMARCD3,RQCD1,NCOR1,MEF2A,SETD8,PIAS2,TRIM28,UBP1,TC
F4,NFYC,SS18,TGFB1I1,ING4,NR2C2,DCAF6,ARNT,PHF12,MED6,HIN
FP,SMARCA4,RAD54L2,NCOR2,LMCD1,TSG101
1.17
682
686
2
cell differentiation
biol
ogic
al_p
roce
ss
FZD6,EIF2B4,CADM1,CLMN,IGF1R,LAMB1,NPHP3,RAF1,F11R,COL9A
1,BDNF,SART1,COL2A1,BCL6,TBX2,PTPN22,SPATA20,CNTF,CUX1,S
MAD7,BMP8A,GLG1,ARHGEF12,IL15RA,CD72,LEF1,PAX8,EMX2,ITGA
9,XBP1,UHMK1,ADAM8,CD9,SIPA1L1,MINK1,PDLIM5,PTPN6,ACTR3,L
HX4,VASP,CSNK2A1,PRKACA,JAG2,RC3H1,ZC3H12A,SEPT4,POLM,S
LC11A2,AAMP,CNP,CLN8,TBX18,GIGYF2,FLG,STK4,FGFR1,HPS4,HS
F4,CAPRIN1,CELF1,PDE4D,PAF1,SHARPIN,RNF8,RHBDD1,PRKCH,D
1.06
684
848
7
1.
4
6
E
0
1
1.
4
6
E
0
1
1.
4
6
E
0
1
AZAP1,YY1,SSH2,CREB1,NPTN,ALDH6A1,DFNA5,NF1,ZEB1,NUMA1,
RGMB,COL18A1,MED28,ZNF3,RPS6KA5,NIPBL,RXRB,LMNA,MITF,ITG
A3,RB1,LTBP4,MAPK8IP3,ZFPM2,BLOC1S5,PAFAH1B1,IL18,MTCH1,A
ACS,ARPC2,SYNE1,ADAM15,USP33,NR1H3,HEXA,PLD6,FLCN,NRP1,
MAST2,STX2,VPS72,PTEN,FYN,SRPK1,RUNX2,IQGAP1,FBXW7,SMA
RCD3,GGNBP2,SRGAP2,NCOR1,MEF2A,FECH,TCTN1,CACNB1,MYC
BP2,PBX3,RAB8A,AFF4,TRIM28,CSK,CDK5RAP2,COL9A3,PTPRC,CD
K6,RARRES2,WDR61,FLOT1,STAG2,GOPC,RANBP9,PAK1,NCK2,RAB
10,SEMA6A,TCF4,SEMA4D,CSF1R,HSD17B4,PIWIL4,ROBO3,SMAD4,
C1QTNF3,NAV1,TGFB1I1,DTYMK,EZR,CD276,NR2C2,FLNA,RAB5A,G
LI3,MAPK12,ENG,TCF12,ARNT,NOX4,EXT1,ERCC1,NRBP2,TBCE,ME
D6,UNC5B,MDFI,PTPRD,ITGA5,RGS2,HINFP,PDGFRB,DZIP1,LGALS8,
FARP1,RUNX1,SMARCA4,KIF13B,TLN1,GSK3A,NCOR2,SETD2,COL13
A1,MYO1E,GPHN,STAT6,TANC1,ACIN1,PSD3,ROBO2,CACNB3,PMP2
2,CLIC4,CDK5RAP1,BNIP2,NTRK1,SPATA6,SMAD9,DUSP6,TGFBR3,Z
BTB16,SEPT2,PDPK1,TSG101,FOXC1,ACAN,STK24,SEMA4B,SSH1,C
DK5RAP3,EYA2,WNK1,CLASP1,TENM4,GATA2
G
O:
00
06
87
9
G
O:
00
30
20
3
cellular iron ion homeostasis
biol
ogic
al_p ATP6V1D,SLC11A2,TTC7A,CP,ATP6V0A1,MCOLN1,NUBP1,MFI2
roce
ss
1.53
972
942
8
glycosaminoglycan metabolic process
biol
ogic
ST3GAL1,XYLT1,ST3GAL4,GCNT2,HEXA,UST,HGSNAT,GUSB,B4GAL
al_p
T4,EXT1,B3GAT3,PDGFRB,FOXC1,ACAN,FMOD
roce
ss
1.34
726
324
9
1.
4
6
E
0
1
1.
4
6
E
0
1
G
O:
00
48
53
4
hematopoietic or lymphoid organ
development
biol
ogic
al_p
roce
ss
CRIP2,CDK13,TAZ,SART1,BCL6,PTPN22,IL15RA,LEF1,BCL2L11,ADA
M8,MINK1,PTPN6,JAG2,RC3H1,POLM,SLC11A2,STK4,PAF1,NF1,ZEB
1,MITF,RB1,PAFAH1B1,FLCN,RUNX2,NCOR1,MEF2A,TTC7A,FECH,P
TPRC,CDK6,WDR61,CSF1R,GLI3,ARNT,ERCC1,LGALS8,RUNX1,MKN
K2,SMARCA4,CD164,MYO1E,STAT6,ACIN1,NTRK1,TGFBR3,ZBTB16,
GATA2
1.16
730
389
8
actin filament-based process
biol
ogic
al_p
roce
ss
BCL6,ARPC4TTLL3,NISCH,PAM,CAPZB,SIPA1L1,MINK1,RHOF,ACTR3,VASP,PPM1
F,SSH2,LIMCH1,NF1,TPM4,CAPN10,PAFAH1B1,ARPC2,CYTH2,DAAM
1,PHPT1,SRGAP2,MEF2A,WASH4P,VILL,PAK1,NCK2,TRPM7,CSF1R,
ACTR2,EZR,FHOD1,FLNA,SUN2,NOX4,PDGFRB,SDAD1,TLN1,TWF1,
MYO1E,ATXN3,CORO7,PDPK1,SSH1
1.17
618
220
2
calcium-dependent protein binding
mol
ecul
ar_f
unct
ion
MYO1D,SEC31A,STX2,S100PBP,TSG101
1.77
720
563
8
G
O:
00
71
90
0
regulation of protein serine/threonine kinase
activity
biol
ogic
al_p
roce
ss
IGF1R,RAF1,ZFP91,ADAM8,PTPN6,NOD1,PLK1,CCNL1,FAM58A,STK4
,FGFR1,TAB2,CCNL2,NF1,PKD2,MAPK8IP3,RGS3,PTEN,PXN,CSK,PT
PRC,PAK1,CSF1R,NOX4,MDFI,RGS2,PDGFRB,CARD14,IGF2,PDCD4,
CDK5RAP1,NTRK1,SPRED1,TNFRSF10B,DUSP6,PKD1,CDK5RAP3
1.19
541
343
5
G
O:
00
09
embryo development ending in birth or egg
hatching
biol
ogic
al_p
roce
FZD6,NPHP3,PLCD1,COL2A1,LEF1,BCL2L11,VASP,JAG2,TBX18,STK4
,FGFR1,NF1,ZEB1,NIPBL,PKD2,RXRB,MAPK8IP3,ZFPM2,EPN2,FLCN,
RUNX2,IFT172,MEF2A,TCTN1,TRIM28,RARRES2,PSMC4,SMAD4,GLI3
,TMED2,EPN1,VEZT,ARNT,EXT1,MDFI,HINFP,PDGFRB,RUNX1,SMAR
1.16
430
157
4
G
O:
00
30
02
9
G
O:
00
48
30
6
1.
4
7
E
0
1
1.
4
7
E
0
1
1.
4
7
E
0
1
1.
4
7
E
0
1
1.
4
8
E
79
2
G
O:
00
45
78
5
G
O:
00
44
30
9
G
O:
00
43
19
7
G
O:
00
05
64
3
ss
CA4,NCOR2,SETD2,MYO1E,BNIP2,TGFBR3,EGFL8,PKD1,FOXC1,C2C
D3,GATA2
positive regulation of cell adhesion
biol
ogic
UTRN,SMAD7,LEF1,HSD17B12,ADAM8,TBX18,PPM1F,PLEKHA2,ARP
al_p
C2,FLCN,CDK6,ABI3BP,COL8A1
roce
ss
1.37
908
836
5
neuron spine
cell
ular
FMR1,SIPA1L1,MINK1,PDLIM5,PLCB4,SHARPIN,STRN4,FYN,SRGAP2
_co
,RAB8A,GOPC,CANX,TANC1,PSD3
mpo
nent
1.36
046
242
2
dendritic spine
cell
ular
FMR1,SIPA1L1,MINK1,PDLIM5,PLCB4,SHARPIN,STRN4,FYN,SRGAP2
_co
,RAB8A,GOPC,CANX,TANC1,PSD3
mpo
nent
1.36
046
242
2
nuclear pore
cell
ular
_co NUP98,NUTF2,NUP210,SENP2,KPNB1,NUP37,NUP85,KPNA1
mpo
nent
1.53
351
537
2
0
1
1.
4
8
E
0
1
1.
4
9
E
0
1
1.
4
9
E
0
1
1.
4
9
E
0
1
G
O:
00
04
11
2
G
O:
00
04
62
9
G
O:
00
32
58
9
cyclic-nucleotide phosphodiesterase activity
mol
ecul
ar_f
unct
ion
PDE7B,CNP,PDE4D,PDE8A
1.92
953
755
phospholipase C activity
mol
ecul
ar_f
unct
ion
PLCD1,PRKACA,PLCB4,FGFR1,ADCY4,CREB1,BICD1,PDGFRB,PDIA3
,NTRK1
1.45
234
009
1
neuron projection membrane
cell
ular
_co FZD6,MYO1D,MAPK8IP3,ROBO2
mpo
nent
G
O:
00
70
01
1
peptidase activity, acting on L-amino acid
peptides
mol
ecul
ar_f
unct
ion
G
O:
regulation of lipoprotein lipase activity
biol
ogic
1.93
011
417
6
1.
4
9
E
0
1
1.
4
9
E
0
1
1.
4
9
E
0
1
USP10,CRBN,PSMB10,RAF1,NLRP1,DDI2,CPE,DPP4,NLN,USP4,CAS
P4,LEF1,PSMB9,ADAMTS1,BCL2L13,BCL2L11,CPM,SCRN3,USP47,A
DAM8,CSNK2A1,IGBP1,NOD1,PREPL,SLC11A2,ATG4B,DNPEP,USP2
0,C2,CFB,MMP16,MDM2,RHBDD1,PPM1F,RHBDF1,SERPINH1,CAPN1
0,CASP2,USP24,USP3,SENP2,MTCH1,TPP1,CHMP1A,ADAM15,USP33
,USP7,FAP,C1R,LGMN,HERPUD1,ADAMTS18,USP15,AGBL5,CTSH,C3
,C1S,PCSK7,DIABLO,USP40,RHBDF2,LONRF3,ATG4A,PDIA3,ATXN3,
DPP7,LONP2,PSMA1,TNFRSF10B,STAMBPL1,CPAMD8,SENP6,MMP2
5
1.12
813
923
1
1.
5
0
E
0
1
FKBP1A,NR1H3,PDGFRB,LMF1
1.92
466
1.
5
00
51
00
4
G
O:
00
70
53
4
G
O:
00
21
95
5
G
O:
00
00
27
2
G
O:
00
43
50
2
al_p
roce
ss
178
5
protein K63-linked ubiquitination
biol
ogic
al_p ZFP91,RNF8,RNF168,UBR5
roce
ss
1.92
466
178
5
central nervous system neuron
axonogenesis
biol
ogic
al_p PAFAH1B1,PTEN,TCTN1,MYCBP2
roce
ss
1.92
466
178
5
polysaccharide catabolic process
biol
ogic
al_p PHKG2,GAA,PGM2,PHKG1
roce
ss
1.92
466
178
5
regulation of muscle adaptation
biol
ogic
al_p CAMK2D,RGS2,GSK3A,LMCD1
roce
ss
1.92
466
178
5
0
E
0
1
1.
5
0
E
0
1
1.
5
0
E
0
1
1.
5
0
E
0
1
1.
5
0
E
0
1
G
O:
00
07
27
5
multicellular organismal development
FZD6,PBX2,CRIP2,EIF2B4,CADM1,RAI1,CKB,CLMN,IGF1R,LAMB1,NP
HP3,PTS,SIRT2,UTRN,RAF1,COL9A1,CDK13,BDNF,TAZ,SIN3B,CPE,P
LCD1,SART1,COL2A1,SUPT20H,LUC7L,BCL6,TBX2,PTPN22,SPATA20
,CNTF,CUX1,FMR1,SMAD7,BMP8A,GLG1,ARHGEF12,EHMT1,RNH1,IL
15RA,CD72,LEF1,PAX8,EMX2,ITGA9,ADAMTS1,BCL2L11,MEPE,XBP1,
PAM,MARK4,UHMK1,ADAM8,CD9,SIPA1L1,KRIT1,MINK1,PDLIM5,PTP
N6,ACTR3,LHX4,VASP,CSNK2A1,PRKACA,SDCCAG8,ASNS,JAG2,RC
3H1,CHD6,ZC3H12A,SEPT4,POLM,SLC11A2,DIP2A,AAMP,LSAMP,CN
P,CLN8,TBX18,JHDM1D,GIGYF2,FLG,STK4,TRO,FGFR1,RAB18,HSF4,
DISP1,CAPRIN1,CELF1,PAF1,TAB2,SHARPIN,RNF8,COL12A1,FKBP1
A,PRKCH,DAZAP1,YY1,SSH2,THBS3,PFDN5,CREB1,NPTN,FLII,DFNA
5,NF1,ZEB1,CRIP1,NUMA1,RGMB,COL18A1,EBF1,NPR1,ZNF3,RPS6K
A5,NIPBL,GCNT2,PKD2,CASP2,SLC12A6,RXRB,LMNA,MITF,ITGA3,RB
biol 1,LTBP4,MAPK8IP3,ZFPM2,BLOC1S5,RNF168,PAFAH1B1,SENP2,IL18
ogic ,MTCH1,TPP1,AACS,EPN2,ADAM15,USP33,HEXA,USP7,PLD6,FLCN,N
al_p RP1,TENC1,STX2,PTEN,FYN,ALDH1A3,IDH1,RUNX2,IQGAP1,FBXW7,
roce SMARCD3,IFT172,CTNS,GGNBP2,PXN,SRGAP2,NCOR1,MEF2A,DYM,
ss
OXCT1,TTC7A,FECH,ITGB5,TCTN1,CACNB1,MAPK8,MYCBP2,MYLK,
DDX41,MAN1A2,PBX3,RAB8A,TRIM28,CSK,CDK5RAP2,COL9A3,PTPR
S,PTPRC,SWAP70,IMPDH1,UBP1,CDK6,RARRES2,WDR61,EBF4,FLO
T1,PSMC4,RANBP9,PAK1,EVC,NCK2,LEPR,RAB10,SEMA6A,CTSH,TC
F4,ACD,SEMA4D,CSF1R,ERC1,C3,HSD17B4,PIWIL4,ROBO3,SMAD4,
CHURC1,CHURC1FNTB,NAV1,TGFB1I1,DDAH1,LMBR1,EZR,CD276,NR2C2,FLNA,RAB5
A,ATP5A1,GLI3,TMED2,SDCBP2,MAPK12,EPN1,VEZT,ENG,TCF12,AR
NT,NOX4,EXT1,ERCC1,GAA,BICC1,NRBP2,PRELID1,STK36,SDHA,W
WP1,ARHGEF7,TBCE,UNC5B,MDFI,PTPRD,ITGA5,HINFP,LPCAT1,PD
GFRB,COL8A1,DZIP1,LGALS8,EPOR,FARP1,RUNX1,MKNK2,SMARCA
4,KIF13B,TLN1,FGF14,CD164,PHC3,GSK3A,ANKRD6,ITGA11,NLGN2,
NCOR2,FPGS,SETD2,EMP1,COL13A1,IGF2,PTGIS,MYO1E,ATXN3,GP
HN,STAT6,TANC1,ACIN1,PSD3,ROBO2,CACNB3,PMP22,CLIC4,CDK5
1.05
108
025
2
1.
5
2
E
0
1
RAP1,BNIP2,NTRK1,SPATA6,SPRED1,SMAD9,DUSP6,CTTNBP2,TGF
BR3,ZBTB16,EGFL8,SEPT2,PKD1,PDPK1,TSG101,FOXC1,ACAN,STK2
4,SEMA4B,SSH1,CDK5RAP3,C2CD3,EYA2,PHC2,WNK1,CLASP1,TEN
M4,GATA2,BCL2L2
G
O:
00
40
01
3
G
O:
00
05
81
4
G
O:
00
01
10
4
G
O:
00
51
44
3
negative regulation of locomotion
biol
ogic
SMAD7,NISCH,KRIT1,PTPRK,NF1,IFITM3,FLCN,NRP1,PTEN,SRGAP2,
al_p
ENG,ROBO2,CLIC4,TGFBR3,STK24
roce
ss
1.33
834
097
6
centriole
cell
ular
_co STARD9,CEP135,SDCCAG8,HERC2,PLK2,DZIP1,BNIP2
mpo
nent
1.57
989
184
5
RNA polymerase II transcription cofactor
activity
mol
ecul
ar_f
unct
ion
HDGF,TBX18,ZFPM2,TP53BP1,MEF2A,PHF12,MED6,SMARCA4
1.52
188
877
2
positive regulation of ubiquitin-protein ligase
activity
biol
ogic
PSMB10,PSMB9,ANAPC4,PLK1,PTEN,PSMC6,PSMC4,CDC14B,PSMA
al_p
1
roce
ss
1.47
870
356
6
1.
5
2
E
0
1
1.
5
2
E
0
1
1.
5
3
E
0
1
1.
5
3
E
0
1
G
O:
00
50
90
5
neuromuscular process
biol
ogic
al_p CLN8,GIGYF2,PAFAH1B1,TPP1,HEXA,PTEN,GAA,FGF14,NLGN2
roce
ss
1.47
870
356
6
microtubule organizing center part
cell
ular
STARD9,CEP135,SDCCAG8,HERC2,PLK2,CDK5RAP2,FLOT1,DZIP1,B
_co
NIP2,CLASP1
mpo
nent
1.44
261
111
1
embryonic heart tube development
biol
ogic
al_p NPHP3,TBX2,PKD2,MEF2A,TMED2,ENG,FOXC1,C2CD3
roce
ss
1.51
804
309
8
G
O:
00
31
33
0
negative regulation of cellular catabolic
process
biol
ogic
al_p UBXN1,NPC1,TBC1D14,WAC,NRBP2,GSK3A,PABPC1
roce
ss
1.57
180
712
4
G
O:
00
45
negative regulation of myeloid cell
differentiation
biol
ogic
PAF1,NF1,CDK6,WDR61,RUNX1,ZBTB16,GATA2
al_p
roce
1.57
180
712
4
G
O:
00
44
45
0
G
O:
00
35
05
0
1.
5
3
E
0
1
1.
5
4
E
0
1
1.
5
5
E
0
1
1.
5
5
E
0
1
1.
5
5
E
63
8
G
O:
00
06
73
3
G
O:
00
32
77
4
ss
oxidoreduction coenzyme metabolic
process
biol
ogic
al_p H6PD,FDXR,NADSYN1,NADK,FMO2,IDH1,IDH3B
roce
ss
RNA biosynthetic process
FZD6,PBX2,KANK2,GTF3C2,RAI1,SIRT2,MYNN,NOC2L,ZNF131,RSC1
A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20H,PWP1,BCL6,FUB
P1,ZNF783,TBX2,MMS19,CUX1,EED,SMAD7,MCF2L,HDAC6,EHMT1,Z
NF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,
XBP1,PAM,APITD1,USP47,ADAM8,POLR3E,GABPB1,PCGF6,EEF1A1,
LHX4,CSNK2A1,IGBP1,NOD1,STAT2,PLK1,ZNF446,PTGES2,ZNF621,
HDGF,PPP5C,CCNL1,CHD6,ZC3H12A,FAM58A,TBX18,LBX2,PCGF1,D
R1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,WAC,ZNF142,FUBP3,Z
NF540,FGFR1,HSF4,GTF3C1,PAF1,TAB2,SGK1,DPF2,MDM2,PRKCH,
biol
PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,FLII,RPRD1A,
ogic
DDX58,RPL27,CCNL2,PTPRK,ZEB1,IFITM3,ASCC2,RGMB,EBF1,RPL9,
al_p
MED28,ZNF3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF
roce
,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,ZNF865,SENP2,SUB1,CHMP1A,P
ss
DE8A,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,USP7,FLCN,ZN
F605,ZNF410,RPL24,RPL37A,SAP30BP,VPS72,PTEN,RNASEK,RUNX2
,CSTF1,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,PPP1R10,ME
F2A,SETD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX3,ZNF565,ABC
A2,AFF4,TRIM28,DMTF1,CDK5RAP2,UBP1,WDR61,EBF4,ZNF148,ZNF
76,SP110,NCK2,TCF4,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,NFYC,SR
SF10,SS18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,RPL4,ZNF44,CREBZF,ING4,ZN
F687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,MAPK12,CCDC59,DCA
1.57
180
712
4
1.05
598
430
7
0
1
1.
5
5
E
0
1
1.
5
5
E
0
1
F6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,ZNF692,PHF1,STK36,WWP1,P
HF12,MED6,MDFI,ZNF554,HINFP,NCBP2,MLX,TGS1,CDK11A,GLIS3,E
LP6,BDP1,RUNX1,SMARCA4,NAA16,LRPPRC,RPLP0,RAD54L2,ZNF51
8B,CRCP,ZNF90,ZNF638,PER3,SNRPE,ZNF383,POLR2J3,NCOR2,SET
D2,IGF2,PTGIS,TROVE2,ATXN3,PHF21A,PDCD4,SOX13,CHD2,STAT6
,ZNF138,ZNF705A,NTRK1,TFAM,BRWD1,SMAD9,TGFBR3,ZBTB16,BA
Z2A,RRP8,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,CDK5R
AP3,EYA2,SMARCAD1,CC2D1A,GATA2,PABPN1
G
O:
00
30
51
8
intracellular steroid hormone receptor
signaling pathway
biol
ogic
KANK2,HDAC6,RB1,RQCD1,PIAS2,PAK1,TGFB1I1,SMARCA4,PPAP2A
al_p
,CRIPAK,UBR5
roce
ss
1.41
141
864
2
protein binding transcription factor activity
mol
ecul
ar_f
unct
ion
NOC2L,SIN3B,SUPT20H,MMS19,RBPMS,HDGF,TBX18,DR1,HSF4,YY1
,GMEB2,PFDN5,CREB1,ZEB1,RXRB,RB1,ZFPM2,TP53BP1,SUB1,NR1
H3,SMARCD3,RQCD1,NCOR1,MEF2A,SETD8,PIAS2,TRIM28,UBP1,TC
F4,NFYC,SS18,SMAD4,TGFB1I1,ING4,NR2C2,DCAF6,ARNT,PHF12,M
ED6,HINFP,SMARCA4,RAD54L2,NCOR2,LMCD1,TSG101
1.16
661
099
5
G
O:
00
04
55
3
hydrolase activity, hydrolyzing O-glycosyl
compounds
mol
ecul
ar_f
unct
ion
ENGASE,MAN2C1,EDEM2,HEXA,MAN1A2,GUSB,GAA,MAN2A2,MAN1
B1,CTBS
1.43
688
966
5
G
O:
00
specific granule
cell
ular
_co
ADAM8,SNAP23
2.79
866
555
G
O:
00
00
98
8
1.
5
5
E
0
1
1.
5
6
E
0
1
1.
5
7
E
0
1
1.
5
7
42
58
1
G
O:
00
72
54
6
G
O:
00
08
38
5
G
O:
00
33
36
5
G
O:
00
06
48
6
mpo
nent
5
ER membrane protein complex
cell
ular
_co EMC3,EMC4
mpo
nent
2.79
866
555
5
IkappaB kinase complex
cell
ular
_co IKBKB,ERC1
mpo
nent
2.79
866
555
5
protein localization to organelle
biol
ogic
al_p
roce
ss
MARCH5,BCL6,GPAA1,NUP98,RBPMS,KPNA6,PLK1,VAMP7,TIMM23,
MDM2,SRP9,DDX58,RPL27,NF1,RPL9,PKD2,LMNA,RB1,SYNE1,BICD1
,GCC2,FLCN,RPL24,RPL37A,KPNB1,PPP1R10,ACD,TIMM50,OS9,SMA
D4,GRPEL2,C1QTNF3,RPL4,FLNA,SUN2,GLI3,SLC25A6,MDFI,RPLP0,
PDIA3,LONP2,SPCS3,PKD1,KPNA1,UBR5
1.16
590
088
9
protein glycosylation
biol
ogic SIRT2,ST3GAL1,NPC1,SEC31A,MCFD2,ALG6,ST3GAL4,GCNT2,EDEM
al_p 2,GALNT2,MAN1A2,ST6GALNAC5,FUT4,MGAT5,B4GALT4,EXT1,B3GA
roce T3,MAN2A2,MAN1B1,CANX,PDIA3,LMF1,SIRT3,ALG9
ss
1.24
362
761
5
E
0
1
1.
5
7
E
0
1
1.
5
7
E
0
1
1.
5
7
E
0
1
1.
5
8
E
0
1
G
O:
00
43
41
3
G
O:
00
19
31
8
G
O:
00
71
34
6
G
O:
00
03
23
1
G
O:
00
10
macromolecule glycosylation
biol
ogic SIRT2,ST3GAL1,NPC1,SEC31A,MCFD2,ALG6,ST3GAL4,GCNT2,EDEM
al_p 2,GALNT2,MAN1A2,ST6GALNAC5,FUT4,MGAT5,B4GALT4,EXT1,B3GA
roce T3,MAN2A2,MAN1B1,CANX,PDIA3,LMF1,SIRT3,ALG9
ss
1.24
362
761
5
hexose metabolic process
biol
ogic SPATA20,H6PD,NISCH,PRKACA,GALK2,MAN2C1,GALT,GRB10,NCOR
al_p 1,SMEK1,PHKG2,FUT4,C1QTNF3,ARNT,GAPDH,GAA,MAN2A2,ENO4,
roce GSK3A,IGF2,PGM2,PHKG1,USF1
ss
1.24
947
801
4
cellular response to interferon-gamma
biol
ogic
HLA-DPB1,HLA-C,HLA-DQA1,PTPN6,CAMK2D,IL18,NR1H3,HLAal_p
F,IRF9,GAPDH
roce
ss
1.43
325
877
6
cardiac ventricle development
biol
ogic
CPE,SMAD7,FKBP1A,ZFPM2,SMARCD3,MEF2A,GAA,GSK3A,TGFBR3
al_p
,FOXC1
roce
ss
1.43
325
877
6
regulation of phosphatase activity
biol
ogic MYO1D,FKBP1A,ZCCHC9,SYTL2,MEF2A,SEMA4D,PDGFRB,FARP1,S
al_p PRED1,WNK1
roce
1.43
325
877
6
1.
5
8
E
0
1
1.
5
8
E
0
1
1.
5
9
E
0
1
1.
5
9
E
0
1
1.
5
9
E
92
1
G
O:
00
51
53
9
G
O:
00
32
93
4
G
O:
00
02
69
6
G
O:
00
05
17
8
ss
4 iron, 4 sulfur cluster binding
mol
ecul
ar_f
unct
ion
sterol binding
mol
ecul
ar_f
unct
ion
positive regulation of leukocyte activation
biol
ogic SART1,HLA-DPB1,DPP4,BCL6,IL15RA,HLAal_p DQA1,ADAM8,PTPN6,IL18,FYN,MEF2A,CSK,PTPRC,PAK1,NCK2,CD27
roce 6,GLI3,LGALS8,TNFRSF14,IGF2,STAT6,PDPK1
ss
1.25
592
336
8
integrin binding
mol
ecul
ar_f
unct
ion
1.46
458
874
3
TYW1B,NDUFV1,NDUFS2,NUBP1,CDK5RAP1
1.73
163
626
3
NPC1,STARD3,NR1H3,OSBPL3,HSD17B4
1.73
163
626
3
LAMB1,UTRN,NISCH,CD9,COL16A1,LTBP4,PXN,ITGB5,ITGA5
0
1
1.
5
9
E
0
1
1.
5
9
E
0
1
1.
5
9
E
0
1
1.
6
0
E
0
1
G
O:
00
30
42
5
G
O:
00
46
65
1
G
O:
19
01
18
5
G
O:
00
42
05
9
G
O:
00
50
dendrite
cell
ular
_co
mpo
nent
lymphocyte proliferation
biol
ogic
CADM1,PSMB10,BTN3A1,BCL6,PTPN22,LEF1,PTPN6,RC3H1,IL18,FY
al_p
N,MEF2A,PTPRC,IMPDH1,NCK2,CD276,TNFRSF14,IGF2,CD151
roce
ss
1.28
993
289
8
negative regulation of ERBB signaling
pathway
biol
ogic
al_p HGS,EPS15L1,EPN1,ARHGEF7,STAM2
roce
ss
1.72
726
057
6
negative regulation of epidermal growth
factor receptor signaling pathway
biol
ogic
al_p HGS,EPS15L1,EPN1,ARHGEF7,STAM2
roce
ss
1.72
726
057
6
pigment cell differentiation
biol
ogic
HPS4,MITF,BLOC1S5,MEF2A,GLI3
al_p
roce
1.72
726
057
6
CADM1,UBXN1,FMR1,UHMK1,SIPA1L1,MINK1,PDLIM5,PLCB4,TNK2,C
APRIN1,ADCY4,SHARPIN,PTPRK,NF1,STRN4,MAPK8IP3,PLK2,FYN,S
RGAP2,RAB8A,GOPC,PAK1,RHEB,FARP1,CANX,TANC1,PSD3,NTRK1
,KPNA1
1.21
498
953
7
1.
6
0
E
0
1
1.
6
0
E
0
1
1.
6
0
E
0
1
1.
6
0
E
0
1
1.
6
0
E
93
1
G
O:
00
16
36
3
G
O:
00
31
90
1
G
O:
00
31
25
3
G
O:
00
44
21
2
ss
nuclear matrix
cell
ular
PRPF40A,YY1,NUMA1,CHMP1A,SRPK1,TGFB1I1,ATXN3,CLIC4,SMAR
_co
CAD1
mpo
nent
1.46
441
802
3
early endosome membrane
cell
ular
_co HGS,HLA-C,SNX13,WASH4P,HLA-F,APPL2,RAB5A,STAM2,NTRK1
mpo
nent
1.46
441
802
3
cell projection membrane
cell
ular
FZD6,MYO1D,DPP4,RAB35,VASP,BBS1,DDX58,MAPK8IP3,FAP,CLTB,
_co
EVC,EZR,ITGA5,TLN1,TWF1,ROBO2,SEPT2
mpo
nent
1.29
992
662
4
transcription regulatory region DNA binding
mol
ecul
ar_f
unct
ion
1.20
060
114
2
SMAD7,LEF1,PAX8,EMX2,GABPB1,TBX18,TBP,YY1,CREB1,ZEB1,RX
RB,RB1,MZF1,NR1H3,RUNX2,NCOR1,MEF2A,CDK5RAP2,ZNF148,HN
RNPL,TCF4,SMAD4,TCF12,HINFP,SMARCA4,NCOR2,ATXN3,STAT6,T
FAM,FOXC1,CC2D1A,GATA2
0
1
1.
6
0
E
0
1
1.
6
0
E
0
1
1.
6
1
E
0
1
1.
6
1
E
0
1
intracellular protein kinase cascade
IGF1R,RAF1,CNTF,VRK2,HGS,ADAM8,MINK1,PTPN6,IGBP1,NOD1,PR
KACA,STAT2,PPP5C,SHISA5,MIB2,STK4,FGFR1,TAB2,SHARPIN,FKB
biol
P1A,PRKCH,CREB1,PLEKHG5,NF1,RPS6KA5,PKD2,MAPK8IP3,PAFA
ogic
H1B1,IL18,STK38L,RGS3,PLK2,FLCN,PTEN,FYN,SRPK1,FBXW7,IKBK
al_p
B,PXN,LTBR,NCOR1,MEF2A,MAPK8,MAP4K4,CSK,PTPRC,PAK1,LEP
roce
ROT,CTSH,CSF1R,ERC1,SS18,C1QTNF3,TANK,APOL3,FLNA,MAPK12
ss
,NOX4,MDFI,RGS2,PDGFRB,MKNK2,FGF14,IGF2,PDCD4,BNIP2,NTRK
1,SPRED1,TNFRSF10B,DUSP6,TGFBR3,PKD1,PDPK1,WNK1,CC2D1A
positive regulation of viral reproduction
biol
ogic
SUPT5H,VAPB,LEF1,SUPT4H1,RAD23A,IFITM3,SRPK1,NCBP2,SMAR
al_p
CA4
roce
ss
1.46
088
786
1
fatty-acyl-CoA binding
mol
ecul
ar_f
unct
ion
GCDH,ALDH6A1,ACBD4
2.13
264
676
6
G
O:
00
00
17
5
3-5-exoribonuclease activity
mol
ecul
ar_f
unct
ion
DIS3L,PAN2,PARN
2.13
264
676
6
G
O:
00
RNA polymerase II transcription
corepressor activity
mol
ecul
ar_f
HDGF,TBX18,PHF12
2.13
264
676
G
O:
00
07
24
3
G
O:
00
48
52
4
G
O:
00
00
06
2
1.12
022
997
5
1.
6
1
E
0
1
1.
6
1
E
0
1
1.
6
2
E
0
1
1.
6
2
E
0
1
1.
6
2
01
10
6
G
O:
00
48
86
4
G
O:
00
48
01
7
G
O:
00
48
01
5
G
O:
00
34
50
4
unct
ion
6
stem cell development
biol
ogic
PAX8,PAF1,MED28,NIPBL,VPS72,PTPRC,STAG2,MED6,SMARCA4,SE
al_p
TD2,GATA2
roce
ss
1.39
810
337
2
inositol lipid-mediated signaling
biol
ogic
IGF1R,PTPN6,FGFR1,MDM2,CREB1,NF1,PTEN,NCOR1,SEMA4D,CSF
al_p
1R,PDGFRB,GSK3A,NTRK1,PDPK1
roce
ss
1.33
770
819
1
phosphatidylinositol-mediated signaling
biol
ogic
IGF1R,PTPN6,FGFR1,MDM2,CREB1,NF1,PTEN,NCOR1,SEMA4D,CSF
al_p
1R,PDGFRB,GSK3A,NTRK1,PDPK1
roce
ss
1.33
770
819
1
protein localization to nucleus
biol
ogic BCL6,NUP98,RBPMS,KPNA6,MDM2,DDX58,NF1,PKD2,LMNA,SYNE1,F
al_p LCN,KPNB1,PPP1R10,SMAD4,C1QTNF3,FLNA,SUN2,GLI3,MDFI,PDIA
roce 3,PKD1,KPNA1,UBR5
ss
1.24
446
003
E
0
1
1.
6
2
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
G
O:
00
10
45
8
exit from mitosis
biol
ogic
al_p SIRT2,SIRT7,CLASP1
roce
ss
2.12
725
776
2
negative regulation of autophagy
biol
ogic
al_p NPC1,TBC1D14,NRBP2
roce
ss
2.12
725
776
2
regulation of ryanodine-sensitive calciumrelease channel activity
biol
ogic
al_p CAMK2D,FKBP1A,PKD2
roce
ss
2.12
725
776
2
G
O:
00
51
64
7
nucleus localization
biol
ogic
al_p PAFAH1B1,SUN2,CIZ1
roce
ss
2.12
725
776
2
G
O:
00
45
negative regulation of cyclin-dependent
protein kinase activity
biol
ogic
PLK1,PTEN,CDK5RAP1
al_p
roce
2.12
725
776
2
G
O:
00
10
50
7
G
O:
00
60
31
4
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
73
6
G
O:
00
45
88
0
G
O:
00
35
90
9
G
O:
00
90
18
1
G
O:
00
48
33
9
ss
positive regulation of smoothened signaling
pathway
biol
ogic
al_p DISP1,EVC,STK36
roce
ss
2.12
725
776
2
aorta morphogenesis
biol
ogic
al_p TBX2,MYLK,PDGFRB
roce
ss
2.12
725
776
2
regulation of cholesterol metabolic process
biol
ogic
al_p ACADVL,EPHX2,LMF1
roce
ss
2.12
725
776
2
paraxial mesoderm development
biol
ogic
al_p LEF1,FGFR1,FOXC1
roce
ss
2.12
725
776
2
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
G
O:
00
31
06
3
G
O:
00
31
64
8
G
O:
00
21
79
9
G
O:
00
72
17
0
G
O:
00
46
regulation of histone deacetylation
biol
ogic
al_p NIPBL,NCOR1,MAPK8
roce
ss
2.12
725
776
2
protein destabilization
biol
ogic
al_p PLK1,MDM2,CTSH
roce
ss
2.12
725
776
2
cerebral cortex radially oriented cell
migration
biol
ogic
al_p PAFAH1B1,SRGAP2,GLI3
roce
ss
2.12
725
776
2
metanephric tubule development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
2.12
725
776
2
regulation of centrosome cycle
biol
ogic
RANBP1,PLK2,CDK5RAP2
al_p
roce
2.12
725
776
2
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
60
5
G
O:
00
31
36
5
G
O:
00
43
57
6
G
O:
00
08
01
3
G
O:
00
31
20
1
ss
N-terminal protein amino acid modification
biol
ogic
al_p NTMT1,NAA10,NAA16
roce
ss
2.12
725
776
2
regulation of respiratory gaseous exchange
biol
ogic
al_p GLS,PBX3,NLGN2
roce
ss
2.12
725
776
2
beta-catenin binding
mol
ecul
ar_f
unct
ion
1.54
995
639
3
SNARE complex
cell
ular
_co VAMP7,VTI1A,STX16,VAMP4
mpo
nent
SMAD7,HDAC6,LEF1,CSNK2A1,PTPRK,PXN,GLI3
1.86
577
703
6
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
1.
6
3
E
0
1
G
O:
00
01
57
0
G
O:
00
51
43
7
G
O:
00
60
02
1
G
O:
00
15
27
8
G
O:
00
05
vasculogenesis
biol
ogic
al_p ZFPM2,FBXW7,ENG,PDGFRB,SMARCA4,SETD2,MYO1E,FOXC1
roce
ss
1.49
695
916
6
positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell cycle
biol
ogic
al_p PSMB10,PSMB9,ANAPC4,PLK1,PTEN,PSMC6,PSMC4,PSMA1
roce
ss
1.49
695
916
6
palate development
biol
ogic
al_p COL2A1,TBX2,LEF1,MEF2A,SMAD4,GLI3,TGFBR3,MMP25
roce
ss
1.49
695
916
6
calcium-release channel activity
mol
ecul
ar_f
unct
ion
CAMK2D,TPCN2,FKBP1A,PKD2
1.86
300
177
2
carbohydrate metabolic process
biol
ogic
al_p
roce
GK5,SIRT2,ST3GAL1,SPATA20,NUP98,H6PD,NISCH,MPDU1,PRKACA
,NPC1,NUP210,GALK2,MAN2C1,SEC31A,IDH3G,MCFD2,NAGK,ALG6,
ST3GAL4,GCNT2,GALT,ISYNA1,EDEM2,GPCPD1,GALNT2,GRB10,HE
XA,UST,PTEN,IDH1,NCOR1,SMEK1,MAN1A2,NUP37,ST6GALNAC5,P
1.12
841
845
8
1.
6
4
E
0
1
1.
6
4
E
0
1
1.
6
4
E
0
1
1.
6
4
E
0
1
1.
6
4
E
97
5
G
O:
00
30
83
8
G
O:
00
06
82
6
G
O:
00
60
41
5
G
O:
00
46
84
9
ss
HKG2,FUT4,C1QTNF3,SLC23A2,HGSNAT,MGAT5,GUSB,B4GALT4,AR
NT,EXT1,GAPDH,GAA,B3GAT3,NUP85,MAN2A2,MAN1B1,ENO4,CANX
,GSK3A,PDIA3,IGF2,PGM2,CTBS,PHKG1,LMF1,SIRT3,USF1,ACAN,FM
OD,ALG9,RBKS
0
1
positive regulation of actin filament
polymerization
biol
ogic
al_p ARPC4-TTLL3,ACTR3,ARPC2,WASH4P,NCK2,ACTR2
roce
ss
1.61
671
589
9
iron ion transport
biol
ogic
al_p SLC25A37,ATP6V1D,SLC11A2,ATP6V0A1,MCOLN1,MFI2
roce
ss
1.61
671
589
9
muscle tissue morphogenesis
biol
ogic
al_p SMAD7,FKBP1A,ZFPM2,MYLK,GAA,TGFBR3,FOXC1
roce
ss
1.54
603
979
4
bone remodeling
biol
ogic
al_p ADAM8,NF1,MITF,TPP1,CSK,CSF1R,NOX4
roce
ss
1.54
603
979
4
1.
6
4
E
0
1
1.
6
4
E
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
G
O:
00
00
27
1
G
O:
00
46
85
0
G
O:
00
07
15
7
G
O:
00
43
47
0
G
O:
00
10
polysaccharide biosynthetic process
biol
ogic
al_p GRB10,PHKG2,EXT1,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.54
603
979
4
regulation of bone remodeling
biol
ogic
al_p ADAM8,NF1,CSK,CSF1R
roce
ss
1.85
829
413
7
heterophilic cell-cell adhesion
biol
ogic
al_p CADM1,PTPRD,ITGA5,CD164
roce
ss
1.85
829
413
7
regulation of carbohydrate catabolic
process
biol
ogic
al_p NCOR1,PHKG2,ARNT,GSK3A
roce
ss
1.85
829
413
7
epithelial cell migration
biol
ogic
HDAC6,PPM1F,CTSH,TGFBR3
al_p
roce
1.85
829
413
7
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
63
1
G
O:
00
90
13
2
G
O:
00
19
69
2
G
O:
00
08
33
4
G
O:
00
35
85
0
ss
epithelium migration
biol
ogic
al_p HDAC6,PPM1F,CTSH,TGFBR3
roce
ss
1.85
829
413
7
deoxyribose phosphate metabolic process
biol
ogic
al_p CMPK2,DTYMK,AK5,PGM2
roce
ss
1.85
829
413
7
histone mRNA metabolic process
biol
ogic
al_p XRN1,UPF1,NCBP2,SNRPE
roce
ss
1.85
829
413
7
epithelial cell differentiation involved in
kidney development
biol
ogic
al_p PAX8,IQGAP1,MEF2A,MYO1E
roce
ss
1.85
829
413
7
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
G
O:
00
43
47
1
regulation of cellular carbohydrate catabolic
process
biol
ogic
al_p NCOR1,PHKG2,ARNT,GSK3A
roce
ss
cell projection part
cell
ular
_co
mpo
nent
G
O:
00
22
62
5
cytosolic large ribosomal subunit
cell
ular
_co RPL27,RPL9,RPL24,RPL37A,RPL4,RPLP0
mpo
nent
1.61
461
474
3
G
O:
00
02
46
0
adaptive immune response based on
somatic recombination of immune receptors
built from immunoglobulin superfamily
domains
biol
ogic
CADM1,BCL6,LEF1,PTPN6,RC3H1,C2,RNF8,RNF168,IL18,C1R,MEF2A
al_p
,PTPRC,SWAP70,CTSH,C3,C1S,ERCC1,STAT6
roce
ss
1.28
310
785
7
positive regulation of neurogenesis
biol
ogic BDNF,ACTR3,CAPRIN1,PRKCH,NPTN,PAFAH1B1,SMARCD3,SEMA4D
al_p ,GLI3,PTPRD,ROBO2,TENM4
roce
1.37
009
822
G
O:
00
44
46
3
G
O:
00
50
FZD6,MYO1D,SEPT5,GAS8,DPP4,FMR1,TTLL3,UHMK1,RAB35,SIPA1L
1,MINK1,PDLIM5,VASP,CAMK2D,PLCB4,BBS1,TNK2,SHARPIN,DDX58
,PKD2,STRN4,MAPK8IP3,PAFAH1B1,DNALI1,NRP1,FAP,FYN,SRGAP2
,TCTN1,RAB8A,CLTB,AAK1,GOPC,WDR35,PAK1,EVC,CTSH,EZR,ITG
A5,DZIP1,CC2D2A,CANX,PTPN23,TLN1,TTLL11,TWF1,TANC1,PSD3,R
OBO2,TMEM237,SEPT2,C2CD3
1.85
829
413
7
1.14
771
773
5
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
0
1
1.
6
5
E
76
9
G
O:
00
00
18
4
G
O:
00
34
62
2
G
O:
00
15
93
4
G
O:
00
08
64
1
ss
nuclear-transcribed mRNA catabolic
process, nonsense-mediated decay
biol
ogic
UPF3A,UPF1,RPL27,RPL9,PAN2,RPL24,RPL37A,PARN,RPL4,NCBP2,
al_p
RPLP0,PABPC1
roce
ss
cellular macromolecular complex assembly
biol
ogic
al_p
roce
ss
large ribosomal subunit
cell
ular
_co RPL27,RPL9,RSL1D1,RPL24,RPL37A,RPL4,RPLP0,MRPL3
mpo
nent
1.49
262
162
9
small protein activating enzyme activity
mol
ecul
ar_f
unct
ion
2.70
135
257
SFSWAP,TAZ,SART1,CLNS1A,NUP98,HDAC6,ARPC4TTLL3,COG4,DDX23,CAPZB,ACTR3,TTC19,DNM1L,RC3H1,CELF1,SF
3A2,FKBP1A,PIH1D1,RB1,PRMT5,PUM2,ARPC2,DDX6,BICD1,PXN,ER
AL1,WASH4P,VILL,TBCD,COX14,ATPAF2,NCK2,TCF4,ACTR2,SRSF10
,SMAD4,CENPT,BCS1L,TMED2,CIRBP,NCBP2,TGS1,SNRPE,TWF1,TF
AM,SHPRH,TGFBR3,SENP6,FMOD
UBA2,UBA6
1.37
009
822
1.15
210
993
4
0
1
1.
6
5
E
0
1
1.
6
6
E
0
1
1.
6
6
E
0
1
1.
6
6
E
0
1
G
O:
00
08
15
8
G
O:
00
08
14
3
G
O:
00
31
54
3
G
O:
00
70
01
6
G
O:
00
05
hedgehog receptor activity
mol
ecul
ar_f
unct
ion
NPC1,DISP1
2.70
135
257
poly(A) RNA binding
mol
ecul
ar_f
unct
ion
RBPMS,PABPC1
2.70
135
257
peptidyl-proline dioxygenase activity
mol
ecul
ar_f
unct
ion
LEPRE1,P4HB
2.70
135
257
armadillo repeat domain binding
mol
ecul
ar_f
unct
ion
LEF1,STRN4
2.70
135
257
spindle microtubule
cell
ular
PLK1,NUMA1,PAFAH1B1,NCOR1,CLASP1
_co
mpo
1.70
650
338
7
1.
6
6
E
0
1
1.
6
6
E
0
1
1.
6
6
E
0
1
1.
6
6
E
0
1
1.
6
6
E
87
6
G
O:
00
60
03
3
G
O:
00
16
23
9
G
O:
00
06
45
0
G
O:
00
60
31
5
nent
anatomical structure regression
biol
ogic
al_p LEF1,SMAD9
roce
ss
2.69
452
649
9
positive regulation of macroautophagy
biol
ogic
al_p SUPT5H,WAC
roce
ss
2.69
452
649
9
regulation of translational fidelity
biol
ogic
al_p VARS,LARS
roce
ss
2.69
452
649
9
negative regulation of ryanodine-sensitive
calcium-release channel activity
biol
ogic
al_p FKBP1A,PKD2
roce
ss
2.69
452
649
9
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
G
O:
00
35
02
4
G
O:
00
60
87
2
G
O:
00
60
39
1
G
O:
00
70
87
4
G
O:
00
43
negative regulation of Rho protein signal
transduction
biol
ogic
al_p BCL6,FLCN
roce
ss
2.69
452
649
9
semicircular canal development
biol
ogic
al_p GLI3,GATA2
roce
ss
2.69
452
649
9
positive regulation of SMAD protein import
into nucleus
biol
ogic
al_p RBPMS,SMAD4
roce
ss
2.69
452
649
9
negative regulation of glycogen metabolic
process
biol
ogic
al_p GRB10,GSK3A
roce
ss
2.69
452
649
9
ossification involved in bone maturation
biol
ogic
THBS3,SEMA4D
al_p
roce
2.69
452
649
9
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
93
1
G
O:
00
71
50
1
G
O:
00
06
46
5
G
O:
00
32
02
6
G
O:
00
10
94
4
ss
cellular response to sterol depletion
biol
ogic
al_p LMNA,FBXW7
roce
ss
2.69
452
649
9
signal peptide processing
biol
ogic
al_p LONP2,SPCS3
roce
ss
2.69
452
649
9
response to magnesium ion
biol
ogic
al_p MDM2,D2HGDH
roce
ss
2.69
452
649
9
negative regulation of transcription by
competitive promoter binding
biol
ogic
al_p SMAD7,CREB1
roce
ss
2.69
452
649
9
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
G
O:
00
30
15
7
G
O:
00
32
93
3
G
O:
00
06
47
4
G
O:
00
72
31
0
G
O:
00
08
pancreatic juice secretion
biol
ogic
al_p NR1H3,WNK1
roce
ss
2.69
452
649
9
SREBP signaling pathway
biol
ogic
al_p LMNA,FBXW7
roce
ss
2.69
452
649
9
N-terminal protein amino acid acetylation
biol
ogic
al_p NAA10,NAA16
roce
ss
2.69
452
649
9
glomerular epithelial cell development
biol
ogic
al_p IQGAP1,MYO1E
roce
ss
2.69
452
649
9
asymmetric cell division
biol
ogic
ACTR3,ZBTB16
al_p
roce
2.69
452
649
9
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
35
6
G
O:
00
51
38
2
G
O:
20
00
11
4
G
O:
00
14
06
7
G
O:
00
70
84
1
ss
kinetochore assembly
biol
ogic
al_p CENPT,SENP6
roce
ss
2.69
452
649
9
regulation of establishment of cell polarity
biol
ogic
al_p KRIT1,RAP1B
roce
ss
2.69
452
649
9
negative regulation of phosphatidylinositol
3-kinase cascade
biol
ogic
al_p PTEN,NCOR1
roce
ss
2.69
452
649
9
inclusion body assembly
biol
ogic
al_p HDAC6,SNCAIP
roce
ss
2.69
452
649
9
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
G
O:
00
22
03
8
G
O:
00
06
62
3
G
O:
00
06
01
2
G
O:
00
71
49
8
G
O:
00
07
corpus callosum development
biol
ogic
al_p PAFAH1B1,PTPRS
roce
ss
2.69
452
649
9
protein targeting to vacuole
biol
ogic
al_p VAMP7,GCC2
roce
ss
2.69
452
649
9
galactose metabolic process
biol
ogic
al_p GALK2,GALT
roce
ss
2.69
452
649
9
cellular response to fluid shear stress
biol
ogic
al_p PKD2,MEF2A
roce
ss
2.69
452
649
9
inner mitochondrial membrane organization
biol
ogic
TAZ,LETM1
al_p
roce
2.69
452
649
9
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
00
7
G
O:
00
45
01
9
G
O:
00
10
22
5
G
O:
00
02
92
3
G
O:
00
72
66
6
ss
negative regulation of nitric oxide
biosynthetic process
biol
ogic
al_p ZC3H12A,PTGIS
roce
ss
2.69
452
649
9
response to UV-C
biol
ogic
al_p MDM2,YY1
roce
ss
2.69
452
649
9
regulation of humoral immune response
mediated by circulating immunoglobulin
biol
ogic
al_p PTPN6,PTPRC
roce
ss
2.69
452
649
9
establishment of protein localization to
vacuole
biol
ogic
al_p VAMP7,GCC2
roce
ss
2.69
452
649
9
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
1.
6
7
E
0
1
G
O:
00
03
71
3
G
O:
00
23
05
6
G
O:
00
05
83
9
transcription coactivator activity
mol
ecul
ar_f
unct
ion
positive regulation of signaling
IGF1R,RAF1,CNTF,HDAC6,LANCL2,BCL2L11,RBPMS,XBP1,ADAM8,MI
NK1,PTPN6,CSNK2A1,NOD1,DNM1L,PPP5C,SHISA5,SEPT4,MIB2,BCL
biol AF1,FGFR1,DISP1,TAB2,SHARPIN,FKBP1A,PRKCH,NPTN,PLEKHG5,
ogic PKD2,MAPK8IP3,PAFAH1B1,NR1H3,GRB10,PLK2,FLCN,PTEN,FBXW7
al_p ,IKBKB,PXN,LTBR,MAPK8,SH3BP2,CSK,PTPRC,RNF146,AAK1,PAK1,
roce EVC,RHEB,SEMA4D,CSF1R,C3,SMAD4,C1QTNF3,TGFB1I1,GOLPH3,
ss
APOL3,FLNA,ENG,ARNT,NOX4,STK36,MDFI,ITGA5,PDGFRB,GSK3A,
ANKRD6,NLGN2,IGF2,PTGIS,CSNK1E,BNIP2,NTRK1,SPRED1,TNFRS
F10B,TGFBR3,LMCD1,UBR5,CC2D1A
MMS19,RBPMS,YY1,GMEB2,ZEB1,RXRB,RB1,ZFPM2,SUB1,NR1H3,S
MARCD3,RQCD1,MEF2A,PIAS2,TRIM28,NFYC,SS18,TGFB1I1,ING4,N
R2C2,DCAF6,ARNT,MED6,HINFP,SMARCA4
1.22
788
753
2
1.
6
7
E
0
1
1.11
438
529
6
1.
6
8
E
0
1
proteasome core complex
cell
ular
_co PSMB10,PSMB9,PSMA1
mpo
nent
2.09
899
916
6
G
O:
00
31
94
1
filamentous actin
cell
ular
_co TPM4,PKD2,PAK1
mpo
nent
2.09
899
916
6
G
O:
clathrin vesicle coat
cell
ular
2.09
899
EPN2,CLTCL1,CLTB
1.
6
8
E
0
1
1.
6
8
E
0
1
1.
6
00
30
12
5
_co
mpo
nent
916
6
immune system process
CRIP2,CADM1,PSMB10,IGF1R,BTN3A1,PPIL2,NLRP1,F11R,SLC16A3,
CDK13,TAZ,SART1,HLADPB1,DPP4,BCL6,PTPN22,GBP3,DYNC1I1,IL15RA,LEF1,HLAC,PSMB9,ITGA9,BCL2L11,XBP1,HLADQA1,ADAM8,POLR3E,XAF1,MINK1,PTPN6,VASP,IGBP1,NOD1,STAT
2,JAG2,RC3H1,ZC3H12A,POLM,SLC11A2,VAMP7,CAMK2D,HLADMB,SLC16A1,JAM2,STK4,SIKE1,C2,CFB,PDE4D,PAF1,TAB2,RNF8,S
biol
EC31A,FKBP1A,PRKCH,CREB1,DDX58,LCP2,NF1,ZEB1,CRIP1,NUB1,I
ogic
FITM3,ATG12,ZNF3,RPS6KA5,MITF,ITGA3,RB1,RNF168,PAFAH1B1,IL
al_p
18,ESAM,SLFN11,CALCOCO2,GALNT2,NR1H3,FLCN,PTEN,FYN,SRP
roce
K1,RUNX2,C1R,PHPT1,LGMN,IKBKB,NCOR1,MEF2A,TTC7A,FECH,IT
ss
GB5,MAPK8,DDX41,HLAF,CSK,PTPRC,PSMC6,SWAP70,IMPDH1,CDK6,RARRES2,WDR61,PS
MC4,PAK1,NCK2,CTSH,SEMA4D,CSF1R,C3,KLC1,TANK,CD276,IRF9,
C1S,GLI3,TCF12,ARNT,GAPDH,ERCC1,PRELID1,NUP85,ITGA5,LGAL
S8,TNFRSF14,CANX,RUNX1,MKNK2,SMARCA4,KIF13B,CRCP,CD164,
PDIA3,IGF2,MYO1E,DYNC1I2,PSMA1,STAT6,ACIN1,CACNB3,NTRK1,
DUSP6,TGFBR3,ZBTB16,CD151,PDPK1,GATA2
G
O:
00
09
10
8
coenzyme biosynthetic process
biol
ogic
PTS,HSD17B12,PNPO,PDXK,GCDH,NADSYN1,NADK,ELOVL1,FPGS,
al_p
GPHN,PANK3
roce
ss
1.38
503
698
5
G
O:
regulation of actin polymerization or
depolymerization
biol
ogic
1.38
503
G
O:
00
02
37
6
ARPC4TTLL3,CAPZB,ACTR3,SSH2,ARPC2,WASH4P,VILL,NCK2,ACTR2,TWF
1.07
751
739
7
8
E
0
1
1.
7
0
E
0
1
1.
7
0
E
0
1
1.
7
00
08
06
4
G
O:
00
19
88
2
G
O:
00
18
20
5
G
O:
00
32
94
3
G
O:
00
48
47
1
al_p 1,SSH1
roce
ss
698
5
antigen processing and presentation
biol
ogic PSMB10,HLA-DPB1,DYNC1I1,HLA-C,PSMB9,HLA-DQA1,NOD1,HLAal_p DMB,SEC31A,LGMN,ITGB5,HLAroce F,PSMC6,PSMC4,CTSH,KLC1,CANX,PDIA3,DYNC1I2,PSMA1
ss
1.25
912
453
2
peptidyl-lysine modification
biol
ogic
NOC2L,HDAC6,EHMT1,LEF1,DR1,MDM2,PHF15,RPS6KA5,FLCN,SET
al_p
D8,WDR61,ING4,MSL1,SMARCA4,SETD2,KANSL3,SIRT3,GATA2
roce
ss
1.27
635
465
7
mononuclear cell proliferation
biol
ogic
CADM1,PSMB10,BTN3A1,BCL6,PTPN22,LEF1,PTPN6,RC3H1,IL18,FY
al_p
N,MEF2A,PTPRC,IMPDH1,NCK2,CD276,TNFRSF14,IGF2,CD151
roce
ss
1.27
635
465
7
perinuclear region of cytoplasm
cell
ular
_co
mpo
nent
1.16
854
511
7
LAMB1,TSTD1,BDNF,PTPN22,PLD1,HDAC6,DYNC1I1,PAM,DNM1L,PT
GES2,NPC1,SLC11A2,CNP,VAMP7,USP20,SEC31A,PPM1F,THBS3,PL
EKHG5,SERBP1,LMNA,PAFAH1B1,PUM2,CALCOCO2,GALNT2,USP33
,BICD1,MTMR14,OSBPL3,RAB8A,CDK5RAP2,NOX4,GAPDH,LRPPRC,
TWF1,CLIC4,BNIP2,SEPT2,GAK,PLA2G16
0
E
0
1
1.
7
0
E
0
1
1.
7
1
E
0
1
1.
7
1
E
0
1
1.
7
1
E
0
1
G
O:
00
33
12
1
regulation of purine nucleotide catabolic
process
biol
ogic
al_p
roce
ss
mitochondrial membrane organization
biol
ogic
al_p TAZ,CNP,CLN8,TIMM50,LETM1
roce
ss
1.68
407
906
2
negative regulation of proteolysis
biol
ogic
al_p UBXN1,HDAC6,CLN8,WAC,NR1H3
roce
ss
1.68
407
906
2
G
O:
00
70
83
0
tight junction assembly
biol
ogic
al_p F11R,PRKACA,PRKCH,TBCD,PARD6G
roce
ss
1.68
407
906
2
G
O:
DNA modification
biol
ogic
1.47
645
G
O:
00
07
00
6
G
O:
00
45
86
1
RAB3GAP2,RALGAPA2,BCL6,ARHGEF12,STARD13,DNAJC10,RANBP
1,SIPA1L1,TBC1D2B,TBC1D10B,TBC1D14,GIT2,FAM13A,SNX13,NF1,
PAFAH1B1,ACAP2,RGS3,ARHGAP9,IQGAP1,SRGAP2,TBCD,ARHGAP
29,SGSM3,SEMA4D,TBC1D22A,TMED2,ARHGEF7,ASAP1,RGS2,BNIP
2,NTRK1,RAPGEF6
EHMT1,ALKBH3,USP7,PLD6,PIWIL4,SMARCA4,BAZ2A,HEMK1
1.18
876
169
1
1.
7
1
E
0
1
1.
7
2
E
0
1
1.
7
2
E
0
1
1.
7
2
E
0
1
1.
7
00
06
30
4
G
O:
00
34
13
4
G
O:
00
06
92
1
G
O:
00
34
13
8
G
O:
00
40
01
1
al_p
roce
ss
287
6
toll-like receptor 2 signaling pathway
biol
ogic
al_p NOD1,TAB2,CREB1,RPS6KA5,IKBKB,MEF2A,MAPK8,DUSP6
roce
ss
1.47
645
287
6
cellular component disassembly involved in
execution phase of apoptosis
biol
ogic
al_p DNM1L,SHARPIN,LMNA,KPNB1,LMNB1,ACIN1,KPNA1,STK24
roce
ss
1.47
645
287
6
toll-like receptor 3 signaling pathway
biol
ogic
al_p NOD1,TAB2,CREB1,RPS6KA5,IKBKB,MEF2A,MAPK8,DUSP6
roce
ss
1.47
645
287
6
locomotion
biol
ogic
al_p
roce
ss
IGF1R,AVL9,LAMB1,PPIL2,RAF1,F11R,SLC16A3,GAS8,COL9A1,BDNF,
COL2A1,DPP4,PLD1,SMAD7,HDAC6,ARHGEF12,CD72,LEF1,EMX2,IT
GA9,NISCH,ADAM8,PRPF40A,KRIT1,MINK1,PTPN6,LHX4,VASP,CSNK
2A1,JAG2,AAMP,SLC16A1,JAM2,FGFR1,PDE4D,SGK1,PPM1F,CREB1,
PLEKHG5,DDX58,PTPRK,RHBDF1,NF1,IFITM3,RGMB,COL18A1,RPS6
KA5,LMNA,ITGA3,MAPK8IP3,NEXN,PAFAH1B1,ESAM,USP33,FLCN,N
1.09
379
686
1
3
E
0
1
1.
7
3
E
0
1
1.
7
3
E
0
1
1.
7
3
E
0
1
1.
7
4
E
0
RP1,FAP,PTEN,FYN,PHPT1,SRGAP2,TNS1,CACNB1,MYCBP2,MYLK,
COL9A3,PTPRC,CDK6,RARRES2,RANBP9,PAK1,NCK2,SEMA6A,CTS
H,SEMA4D,CSF1R,DGKZ,ROBO3,NAV1,EZR,SUN2,GLI3,ENG,NOX4,E
XT1,WWP1,UNC5B,NUP85,ITGA5,PDGFRB,ELP6,TLN1,SETD2,PPAP2
A,ROBO2,CACNB3,CLIC4,NTRK1,TGFBR3,CD151,PDPK1,FOXC1,STK
24,CLASP1
G
O:
00
51
43
8
G
O:
00
18
10
5
G
O:
00
06
35
1
1
regulation of ubiquitin-protein ligase activity
biol
ogic
PSMB10,SMAD7,PSMB9,ANAPC4,PLK1,PTEN,PSMC6,PSMC4,CDC14
al_p
B,PSMA1
roce
ss
1.40
339
921
8
peptidyl-serine phosphorylation
biol
ogic
RAF1,SMAD7,UHMK1,PRKACA,PLK1,CAMK2D,STK4,PPM1F,RPS6KA
al_p
5,MAPK8,PAK1,MAPK12,PKD1
roce
ss
1.33
697
879
7
transcription, DNA-dependent
FZD6,PBX2,KANK2,GTF3C2,RAI1,SIRT2,MYNN,NOC2L,ZNF131,RSC1
A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,PWP1,BCL6,FUBP1,ZNF78
3,TBX2,MMS19,CUX1,EED,SMAD7,MCF2L,HDAC6,EHMT1,ZNF496,LA
NCL2,LEF1,PAX8,SUPT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PA
biol
M,APITD1,USP47,ADAM8,POLR3E,GABPB1,PCGF6,EEF1A1,LHX4,CS
ogic
NK2A1,IGBP1,NOD1,STAT2,PLK1,ZNF446,PTGES2,ZNF621,HDGF,PP
al_p
P5C,CCNL1,CHD6,ZC3H12A,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLA
roce
F1,ZNF721,ZNF397,JHDM1D,ZNF710,WAC,ZNF142,FUBP3,ZNF540,F
ss
GFR1,HSF4,GTF3C1,PAF1,TAB2,SGK1,DPF2,MDM2,PRKCH,PPM1F,Z
NF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,FLII,RPRD1A,DDX58,C
CNL2,PTPRK,ZEB1,ASCC2,RGMB,EBF1,MED28,ZNF3,RPS6KA5,NIPB
L,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,T
1.05
286
577
9
1.
7
4
E
0
1
1.
7
4
E
0
1
1.
7
4
E
0
1
G
O:
00
97
45
8
G
O:
00
05
99
6
neuron part
monosaccharide metabolic process
P53BP1,ZNF865,SENP2,SUB1,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF1
80,BICD1,ZNF276,NR1H3,USP7,FLCN,ZNF605,ZNF410,SAP30BP,VPS
72,PTEN,RNASEK,RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,RQCD1,R
FX7,NCOR1,PPP1R10,MEF2A,SETD8,PIAS2,MAPK8,MYCBP2,USP15,
DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,UBP1,
WDR61,EBF4,ZNF148,ZNF76,SP110,NCK2,TCF4,IKZF5,HMGN2,SEMA
4D,SSBP2,ERC1,NFYC,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHUR
C1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,ZNF44,CREBZF,ING4,ZNF687,
NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,MAPK12,CCDC59,DCAF6,E
NG,SIRT7,ZSCAN5A,TCF12,ARNT,ZNF692,PHF1,STK36,WWP1,PHF12
,MED6,MDFI,ZNF554,HINFP,NCBP2,MLX,TGS1,CDK11A,GLIS3,ELP6,
BDP1,RUNX1,SMARCA4,NAA16,LRPPRC,ZNF518B,CRCP,ZNF90,ZNF
638,PER3,SNRPE,ZNF383,POLR2J3,NCOR2,SETD2,IGF2,PTGIS,TRO
VE2,ATXN3,PHF21A,PDCD4,SOX13,CHD2,STAT6,ZNF138,ZNF705A,N
TRK1,TFAM,BRWD1,SMAD9,TGFBR3,ZBTB16,BAZ2A,RRP8,PHF19,L
MCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,CDK5RAP3,EYA2,SMARCA
D1,CC2D1A,GATA2,PABPN1
FZD6,CADM1,IGF1R,MYO1D,SEPT5,UBXN1,FMR1,PAM,MARK4,UHM
cell K1,SIPA1L1,MINK1,PDLIM5,PPP5C,VAMP7,CAMK2D,PLCB4,TNK2,CA
ular PRIN1,ADCY4,SNCAIP,SHARPIN,SNAP23,FKBP1A,NPTN,PTPRK,NF1,
_co NEK3,STRN4,MAPK8IP3,PAFAH1B1,PLK2,NRP1,PTEN,FYN,IQGAP1,S
mpo MARCD3,SRGAP2,MYCBP2,RAB8A,AAK1,GOPC,PAK1,RHEB,SEMA6
nent A,GNB3,ERC1,ROBO3,ARHGEF7,FARP1,CANX,SMARCA4,KIF13B,NL
GN2,TANC1,PSD3,ROBO2,NTRK1,KPNA1,TENM4
biol
ogic SPATA20,H6PD,NISCH,PRKACA,GALK2,MAN2C1,GALT,GRB10,NCOR
al_p 1,SMEK1,PHKG2,FUT4,C1QTNF3,SLC23A2,ARNT,GAPDH,GAA,MAN2
roce A2,ENO4,GSK3A,IGF2,PGM2,PHKG1,USF1,RBKS
ss
1.13
001
301
1.22
034
714
6
1.
7
5
E
0
1
1.
7
5
E
0
1
G
O:
00
00
07
0
G
O:
00
06
80
9
G
O:
00
30
86
3
G
O:
00
70
08
5
G
O:
00
06
mitotic sister chromatid segregation
biol
ogic
al_p INO80,NIPBL,RB1,CHMP1A,NCAPD3,MAU2
roce
ss
1.58
501
558
7
nitric oxide biosynthetic process
biol
ogic
al_p ZC3H12A,PKD2,DDAH1,PTGIS,HBB,DDAH2
roce
ss
1.58
501
558
7
cortical cytoskeleton
cell
ular
_co LANCL2,CAPZB,TPM4,MED28,EZR,CLASP1
mpo
nent
1.58
415
031
4
glycosylation
biol
ogic SIRT2,ST3GAL1,NPC1,SEC31A,MCFD2,ALG6,ST3GAL4,GCNT2,EDEM
al_p 2,GALNT2,MAN1A2,ST6GALNAC5,FUT4,MGAT5,B4GALT4,EXT1,B3GA
roce T3,MAN2A2,MAN1B1,CANX,PDIA3,LMF1,SIRT3,ALG9
ss
1.22
478
477
2
translational initiation
biol
ogic EIF2B4,FMR1,UHMK1,PAIP1,RPL27,EIF4B,RPL9,RPL24,RPL37A,FEC
al_p H,RPL4,EIF3M,NCBP2,RPLP0,EIF3I,PABPC1
roce
1.29
079
113
7
1.
7
5
E
0
1
1.
7
5
E
0
1
1.
7
6
E
0
1
1.
7
6
E
0
1
1.
7
6
E
41
3
G
O:
00
50
77
8
G
O:
00
30
83
2
G
O:
00
10
82
7
G
O:
00
30
12
0
ss
positive regulation of immune response
biol
ogic
al_p
roce
ss
CADM1,BTN3A1,HLA-DPB1,PTPN22,HLADQA1,ADAM8,PTPN6,VASP,NOD1,RC3H1,C2,CFB,TAB2,PRKCH,CRE
B1,DDX58,LCP2,RPS6KA5,NR1H3,PTEN,FYN,C1R,PHPT1,IKBKB,MEF
2A,MAPK8,CSK,PTPRC,PAK1,C3,C1S,CACNB3,DUSP6,PDPK1
1.18
059
150
7
regulation of actin filament length
biol
ogic ARPC4al_p TTLL3,CAPZB,ACTR3,SSH2,ARPC2,WASH4P,VILL,NCK2,ACTR2,TWF
roce 1,SSH1
ss
1.37
221
256
9
regulation of glucose transport
biol
ogic
al_p NUP98,NUP210,CAPN10,GRB10,CLTCL1,NUP37,C3,NUP85,GSK3A
roce
ss
1.42
651
402
9
vesicle coat
cell
ular
_co SEC31A,EPN2,CLTCL1,CLTB,TMED3
mpo
nent
1.66
587
235
4
0
1
1.
7
7
E
0
1
1.
7
7
E
0
1
1.
7
8
E
0
1
1.
7
8
E
0
1
G
O:
00
71
41
7
G
O:
00
60
28
4
G
O:
00
97
19
3
G
O:
00
45
42
9
G
O:
00
06
cellular response to organic nitrogen
biol
ogic
al_p
roce
ss
IGF1R,RAF1,EEF2K,ATP6V1D,PTPN6,PRKACA,COL16A1,FGFR1,ADC
Y4,MDM2,ZEB1,EIF4B,RAB31,CAPN10,IL18,GRB10,FYN,PXN,DENND4
C,CSK,PAK1,LEPROT,RAB10,RHEB,GNB3,ATP6V0A1,NOX4,GSK3A,I
GF2,NTRK1,PDPK1,USF1,SSH1
1.18
243
849
regulation of cell development
biol
ogic
al_p
roce
ss
BDNF,CNTF,SMAD7,LEF1,PAX8,SIPA1L1,PDLIM5,ACTR3,FGFR1,CAP
RIN1,PRKCH,SSH2,NPTN,NF1,ZEB1,PAFAH1B1,ARPC2,NRP1,PTEN,F
YN,SMARCD3,SRGAP2,MEF2A,CDK5RAP2,SEMA6A,TCF4,SEMA4D,S
MAD4,TGFB1I1,GLI3,TCF12,PTPRD,KIF13B,GSK3A,ROBO2,PMP22,C
DK5RAP1,BNIP2,NTRK1,TGFBR3,STK24,SSH1,CDK5RAP3,TENM4
1.15
329
928
intrinsic apoptotic signaling pathway
biol
ogic
SART1,BCL2L11,DNAJC10,DNM1L,SEPT4,BCLAF1,PPM1F,CUL4A,DIA
al_p
BLO,TNFRSF10B,RRP8,STK24
roce
ss
1.34
726
324
9
positive regulation of nitric oxide
biosynthetic process
biol
ogic
al_p PKD2,DDAH1,HBB,DDAH2
roce
ss
1.79
635
099
9
prostaglandin metabolic process
biol
ogic
PTGES2,PTGR2,PTGR1,PTGIS
al_p
roce
1.79
635
099
9
1.
7
9
E
0
1
1.
7
9
E
0
1
1.
7
9
E
0
1
1.
8
0
E
0
1
1.
8
0
E
69
3
G
O:
00
06
69
2
G
O:
00
72
38
4
G
O:
00
08
03
8
G
O:
00
35
06
5
ss
prostanoid metabolic process
biol
ogic
al_p PTGES2,PTGR2,PTGR1,PTGIS
roce
ss
1.79
635
099
9
organelle transport along microtubule
biol
ogic
al_p DYNC1I1,PAFAH1B1,BICD1,LRPPRC
roce
ss
1.79
635
099
9
neuron recognition
biol
ogic
al_p BDNF,NRP1,ROBO3,ROBO2
roce
ss
1.79
635
099
9
regulation of histone acetylation
biol
ogic
al_p NOC2L,RPS6KA5,FLCN,GATA2
roce
ss
1.79
635
099
9
0
1
1.
8
0
E
0
1
1.
8
0
E
0
1
1.
8
0
E
0
1
1.
8
0
E
0
1
G
O:
00
06
90
6
vesicle fusion
biol
ogic
al_p RAB34,VAMP7,GNAI1,RAB8A
roce
ss
1.79
635
099
9
nuclear membrane
cell
ular SLC16A3,NUP98,IL15RA,SHISA5,NUP210,PAFAH1B1,SENP2,SYNE1,
_co KPNB1,ATP11B,OSBPL3,PAK1,GOLPH3,CDC14B,SUN2,NUP85,LMNB
mpo 1,LRPPRC
nent
1.26
572
814
condensed chromosome
cell
ular
DYNC1I1,APITD1,PLK1,TP53BP1,CHMP1A,DSN1,NUP37,CENPT,SUN
_co
2,ADD3,NUP85,NCAPD3,LRPPRC,NSMCE4A,SEPT2,CLASP1
mpo
nent
1.28
674
278
4
G
O:
00
01
08
5
RNA polymerase II transcription factor
binding
mol
ecul
ar_f
unct
ion
DHX9,TBP,CREB1,RB1,TP53BP1,NCOR1,MEF2A,TCF4
1.46
019
057
8
G
O:
00
01
RNA polymerase II transcription factor
binding transcription factor activity
mol
ecul
ar_f
unct
HDGF,TBX18,CREB1,ZFPM2,TP53BP1,MEF2A,TCF4,PHF12,MED6,SM
ARCA4
1.39
244
977
8
G
O:
00
31
96
5
G
O:
00
00
79
3
1.
8
0
E
0
1
1.
8
0
E
0
1
1.
8
0
E
0
1
1.
8
0
E
0
1
1.
8
0
E
07
6
G
O:
00
51
17
0
G
O:
00
07
21
9
G
O:
00
08
37
3
G
O:
00
15
30
1
ion
nuclear import
biol
ogic
BCL6,NUP98,RBPMS,KPNA6,DDX58,NF1,PKD2,LMNA,KPNB1,PPP1R1
al_p
0,SMAD4,C1QTNF3,FLNA,GLI3,MDFI,TGS1,PDIA3,PKD1,KPNA1,UBR5
roce
ss
1.24
746
597
2
Notch signaling pathway
biol
ogic
TNRC6A,JAG2,MIB2,EPN2,GMDS,FBXW7,NCOR1,CDK6,AAK1,EPN1,
al_p
NCOR2,FOXC1,GATA2
roce
ss
1.32
685
017
sialyltransferase activity
mol
ecul
ar_f
unct
ion
ST3GAL1,ST3GAL4,ST6GALNAC5
2.02
601
442
7
anion:anion antiporter activity
mol
ecul
ar_f
unct
ion
SLC26A6,SLC4A2,SLC4A4
2.02
601
442
7
0
1
1.
8
0
E
0
1
1.
8
1
E
0
1
1.
8
1
E
0
1
1.
8
1
E
0
1
G
O:
00
50
69
9
G
O:
00
17
13
4
G
O:
00
71
77
9
G
O:
00
31
57
1
G
O:
00
31
WW domain binding
mol
ecul
ar_f
unct
ion
fibroblast growth factor binding
mol
ecul
ar_f
unct
ion
G1/S transition checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,DGKZ,PSMA1
roce
ss
1.45
650
081
mitotic cell cycle G1/S transition DNA
damage checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,DGKZ,PSMA1
roce
ss
1.45
650
081
mitotic cell cycle G1/S transition checkpoint
biol
ogic
PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,DGKZ,PSMA1
al_p
roce
1.45
650
081
FAM189B,SHISA5,TNK2
2.02
601
442
7
FGFR1,FIBP,TGFBR3
2.02
601
442
7
1.
8
1
E
0
1
1.
8
1
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
57
5
G
O:
00
08
54
3
G
O:
00
46
94
9
G
O:
00
72
52
5
G
O:
00
15
01
2
ss
fibroblast growth factor receptor signaling
pathway
biol
ogic
RAF1,PRKACA,FGFR1,ADCY4,MDM2,CREB1,NPTN,PTEN,RUNX2,FIB
al_p
P,FGF14,GSK3A,DUSP6,PDPK1
roce
ss
1.30
983
927
fatty-acyl-CoA biosynthetic process
biol
ogic
al_p HSD17B12,GCDH,ELOVL1
roce
ss
2.02
089
487
4
pyridine-containing compound biosynthetic
process
biol
ogic
al_p PNPO,NADSYN1,NADK
roce
ss
2.02
089
487
4
heparan sulfate proteoglycan biosynthetic
process
biol
ogic
al_p XYLT1,EXT1,B3GAT3
roce
ss
2.02
089
487
4
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
G
O:
00
44
00
3
modification by symbiont of host
morphology or physiology
biol
ogic
al_p BCL2L11,SLC25A6,PABPN1
roce
ss
2.02
089
487
4
positive regulation of cardiac muscle cell
proliferation
biol
ogic
al_p TBX2,FGFR1,MEF2A
roce
ss
2.02
089
487
4
regulation of alpha-beta T cell proliferation
biol
ogic
al_p IL18,PTPRC,TNFRSF14
roce
ss
2.02
089
487
4
G
O:
00
30
44
9
regulation of complement activation
biol
ogic
al_p C2,CFB,C3
roce
ss
2.02
089
487
4
G
O:
00
55
ventricular cardiac muscle cell
differentiation
biol
ogic
RXRB,LMNA,MEF2A
al_p
roce
2.02
089
487
4
G
O:
00
60
04
5
G
O:
00
46
64
0
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
01
2
G
O:
00
48
10
3
G
O:
00
10
79
9
G
O:
20
00
25
7
G
O:
00
42
99
4
ss
somatic stem cell division
biol
ogic
al_p LEF1,FGFR1,RAB10
roce
ss
2.02
089
487
4
regulation of peptidyl-threonine
phosphorylation
biol
ogic
al_p SMAD7,PLK1,SPRED1
roce
ss
2.02
089
487
4
regulation of protein activation cascade
biol
ogic
al_p C2,CFB,C3
roce
ss
2.02
089
487
4
cytoplasmic sequestering of transcription
factor
biol
ogic
al_p PKD2,MDFI,PKD1
roce
ss
2.02
089
487
4
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
G
O:
00
60
53
7
G
O:
00
50
77
0
G
O:
00
09
85
5
G
O:
00
07
61
1
G
O:
00
16
muscle tissue development
biol
ogic SIRT2,BDNF,TAZ,SIN3B,LUC7L,TBX2,SMAD7,LEF1,FGFR1,FKBP1A,N
al_p F1,PKD2,RXRB,LMNA,ZFPM2,PTEN,MEF2A,MYLK,PAK1,ENG,GAA,PD
roce GFRB,GSK3A,GPHN,TANC1,TGFBR3,FOXC1,EYA2,TENM4
ss
1.19
482
061
9
regulation of axonogenesis
biol
ogic
SIPA1L1,SSH2,PAFAH1B1,NRP1,PTEN,SEMA4D,KIF13B,ROBO2,STK2
al_p
4,SSH1
roce
ss
1.38
893
118
5
determination of bilateral symmetry
biol
ogic
al_p NPHP3,TBX2,DISP1,PKD2,IFT172,MEF2A,MAPK8,TMED2,ENG,C2CD3
roce
ss
1.38
893
118
5
learning or memory
biol
ogic
BDNF,SLC11A2,CLN8,SGK1,NF1,ITGA3,PAFAH1B1,PLK2,PTEN,FYN,
al_p
CTNS,MEF2A,ITGA5,TANC1,NTRK1
roce
ss
1.29
544
543
2
cell migration
biol
ogic
al_p
roce
1.11
241
919
7
IGF1R,AVL9,LAMB1,PPIL2,F11R,SLC16A3,DPP4,SMAD7,HDAC6,LEF1
,EMX2,ITGA9,NISCH,ADAM8,PRPF40A,KRIT1,MINK1,PTPN6,JAG2,AA
MP,SLC16A1,JAM2,FGFR1,PDE4D,SGK1,PPM1F,PLEKHG5,DDX58,PT
PRK,RHBDF1,NF1,COL18A1,LMNA,ITGA3,NEXN,PAFAH1B1,ESAM,US
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
2
E
0
1
1.
8
3
E
47
7
G
O:
00
46
33
2
G
O:
00
42
58
8
G
O:
00
35
63
1
G
O:
00
71
56
4
ss
P33,FLCN,NRP1,FAP,PTEN,FYN,SRGAP2,TNS1,MYLK,PTPRC,RARRE
S2,NCK2,SEMA6A,CTSH,SEMA4D,CSF1R,DGKZ,ROBO3,NAV1,SUN2,
GLI3,ENG,NOX4,NUP85,ITGA5,PDGFRB,ELP6,SETD2,PPAP2A,CLIC4,
TGFBR3,CD151,PDPK1,FOXC1,STK24
0
1
SMAD binding
mol
ecul
ar_f
unct
ion
zymogen granule
cell
ular
_co GNAI1,TMED2
mpo
nent
2.54
424
141
3
CD40 receptor complex
cell
ular
_co IKBKB,DIABLO
mpo
nent
2.54
424
141
3
npBAF complex
cell
ular
_co SMARCD3,SMARCA4
mpo
nent
2.54
424
141
3
SMAD7,FKBP1A,MEF2A,USP15,SMAD4,TGFB1I1,TGFBR3
1.50
075
142
8
1.
8
3
E
0
1
1.
8
3
E
0
1
1.
8
3
E
0
1
1.
8
3
E
0
1
G
O:
00
05
72
1
G
O:
00
30
13
0
G
O:
00
05
84
5
G
O:
00
05
24
5
G
O:
00
46
centromeric heterochromatin
cell
ular
_co CBX5,NCAPD3
mpo
nent
2.54
424
141
3
clathrin coat of trans-Golgi network vesicle
cell
ular
_co CLTCL1,CLTB
mpo
nent
2.54
424
141
3
mRNA cap binding complex
cell
ular
_co FMR1,NCBP2
mpo
nent
2.54
424
141
3
voltage-gated calcium channel activity
mol
ecul
ar_f
unct
ion
1.64
716
620
1
nitric oxide metabolic process
biol
ogic
PTS,ZC3H12A,PKD2,DDAH1,PTGIS,HBB,DDAH2
al_p
roce
TPCN2,PKD2,CACNB1,CACNB3,CACNA2D1
1.49
695
916
6
1.
8
3
E
0
1
1.
8
3
E
0
1
1.
8
3
E
0
1
1.
8
4
E
0
1
1.
8
5
E
20
9
G
O:
00
90
31
7
G
O:
00
48
70
9
G
O:
00
34
96
8
G
O:
00
30
33
0
ss
negative regulation of intracellular protein
transport
biol
ogic
al_p NF1,PKD2,CSK,GOPC,C1QTNF3,MDFI,PKD1
roce
ss
1.49
695
916
6
oligodendrocyte differentiation
biol
ogic
al_p EIF2B4,CD9,NF1,PTEN,CSK,GLI3,TENM4
roce
ss
1.49
695
916
6
histone lysine methylation
biol
ogic
al_p EHMT1,SETD8,WDR61,PHF1,SETD2,BAZ2A,PHF19
roce
ss
1.49
695
916
6
DNA damage response, signal transduction
by p53 class mediator
biol
ogic
USP10,PSMB10,PSMB9,MDM2,CASP2,SETD8,PSMC6,PSMC4,ING4,P
al_p
SMA1,SPRED1
roce
ss
1.35
962
346
3
0
1
1.
8
5
E
0
1
1.
8
5
E
0
1
1.
8
5
E
0
1
1.
8
5
E
0
1
G
O:
20
00
24
3
G
O:
00
34
59
9
G
O:
00
60
19
1
G
O:
00
35
29
5
G
O:
00
42
positive regulation of reproductive process
biol
ogic
SUPT5H,VAPB,LEF1,SUPT4H1,RAD23A,ZFPM2,IL18,SRPK1,NCBP2,R
al_p
UNX1,SMARCA4
roce
ss
1.35
962
346
3
cellular response to oxidative stress
biol
ogic
HDAC6,VRK2,SLC11A2,MDM2,PTPRK,PKD2,IL18,PXN,ALDH3B1,ARN
al_p
T,HBB
roce
ss
1.35
962
346
3
regulation of lipase activity
biol
ogic
PRKACA,FGFR1,ADCY4,FKBP1A,CREB1,BICD1,NR1H3,RGS2,PDGFR
al_p
B,NTRK1,LMF1
roce
ss
1.35
962
346
3
tube development
biol
ogic
al_p
roce
ss
1.15
989
551
3
mechanoreceptor differentiation
biol
ogic
BDNF,CUX1,JAG2,FGFR1,DFNA5,NTRK1
al_p
roce
FZD6,NPHP3,BDNF,TBX2,CUX1,SMAD7,LEF1,PAX8,BCL2L11,VASP,S
DCCAG8,STK4,FGFR1,NUMA1,PKD2,MAPK8IP3,ZFPM2,IL18,NRP1,FB
XW7,IFT172,PXN,MEF2A,TCTN1,MAN1A2,PAK1,CTSH,CSF1R,SMAD4
,GLI3,TMED2,ENG,SETD2,ROBO2,CLIC4,SMAD9,PKD1,FOXC1,C2CD
3
1.55
453
451
8
1.
8
5
E
0
1
1.
8
5
E
0
1
1.
8
5
E
0
1
1.
8
6
E
0
1
1.
8
6
E
49
0
G
O:
00
51
35
1
G
O:
00
00
07
9
G
O:
20
01
02
0
G
O:
00
42
09
8
ss
positive regulation of ligase activity
biol
ogic
PSMB10,PSMB9,ANAPC4,PLK1,PTEN,PSMC6,PSMC4,CDC14B,PSMA
al_p
1
roce
ss
1.40
992
665
6
regulation of cyclin-dependent protein
kinase activity
biol
ogic
PLK1,CCNL1,FAM58A,CCNL2,PKD2,PTEN,CDK5RAP1,PKD1,CDK5RA
al_p
P3
roce
ss
1.40
992
665
6
regulation of response to DNA damage
stimulus
biol
ogic
BCLAF1,RNF8,MDM2,RNF168,SETD8,TRIM28,NSMCE4A,SPRED1,UB
al_p
R5
roce
ss
1.40
992
665
6
T cell proliferation
biol
ogic
CADM1,PSMB10,BTN3A1,PTPN6,RC3H1,IL18,FYN,PTPRC,NCK2,CD2
al_p
76,TNFRSF14,IGF2,CD151
roce
ss
1.31
687
385
3
0
1
1.
8
7
E
0
1
1.
8
7
E
0
1
1.
8
7
E
0
1
1.
8
8
E
0
1
G
O:
00
50
89
0
G
O:
00
06
11
2
G
O:
00
51
27
2
cognition
biol
ogic
BDNF,SLC11A2,CLN8,SGK1,NF1,NIPBL,ITGA3,PAFAH1B1,PLK2,PTEN
al_p
,FYN,CTNS,MEF2A,ITGA5,TANC1,NTRK1
roce
ss
1.27
551
550
2
energy reserve metabolic process
biol
ogic
PRKACA,ADCY4,GRB10,IQGAP1,PHKG2,LEPR,GNB3,GAA,SLC25A6,
al_p
MLX,RAP1B,GSK3A,IGF2,PGM2,PHKG1,SPCS3
roce
ss
1.27
551
550
2
positive regulation of cellular component
movement
biol
ogic IGF1R,LAMB1,BCL6,HDAC6,LEF1,ADAM8,AAMP,PPM1F,COL18A1,NR
al_p P1,PHPT1,MYLK,PTPRC,RARRES2,SEMA6A,CTSH,SEMA4D,CSF1R,S
roce UN2,NOX4,PDGFRB,ELP6
ss
1.22
478
477
2
G
O:
00
06
25
9
DNA metabolic process
G
O:
microtubule motor activity
USP10,OBFC1,IGF1R,BCL6,MMS19,NUP98,PPFIBP2,EHMT1,PNKP,LE
F1,RAD23A,APITD1,USP47,DHX9,UPF1,HERC2,POLM,PMS1,RNF8,ZF
biol YVE26,YY1,INO80,G3BP1,ALKBH3,NOL8,USP3,TP53BP1,RNF168,CH
ogic MP1A,MUM1,USP7,PLD6,CUL4A,SRPK1,FBXW7,KPNB1,SSBP1,TRIM
al_p 28,PTPRC,SWAP70,STAG2,ZSWIM7,ACD,PIWIL4,INO80E,ING4,RBMS
roce 1,CDC14B,NOX4,ERCC1,NAA10,CIZ1,HINFP,PDGFRB,NCAPD3,RAD5
ss
1B,DBF4,SMARCA4,CHTF8,POLG,ATXN3,CHD2,STAT6,ACIN1,CSNK1
E,NSMCE4A,TFAM,SHPRH,BAZ2A,KPNA1,HEMK1,UBR5,EYA2,SMAR
CAD1
mol
DYNC1I1,STARD9,DNALI1,KIFC2,KLC1,DNHD1,KIF13B,DYNC1I2
ecul
1.
8
9
E
0
1
1.
8
9
E
0
1
1.
8
9
E
0
1
1.10
774
978
3
1.
8
9
E
0
1
1.44
072
1.
8
00
03
77
7
G
O:
00
09
79
9
G
O:
00
31
39
7
G
O:
00
31
66
7
G
O:
00
60
33
3
ar_f
unct
ion
137
1
specification of symmetry
biol
ogic
al_p NPHP3,TBX2,DISP1,PKD2,IFT172,MEF2A,MAPK8,TMED2,ENG,C2CD3
roce
ss
1.37
475
841
8
negative regulation of protein ubiquitination
biol
ogic
PSMB10,UBXN1,SMAD7,USP4,PSMB9,ANAPC4,PSMC6,PSMC4,PSMA
al_p
1,UBR5
roce
ss
1.37
475
841
8
response to nutrient levels
biol
ogic IGF1R,TNRC6A,BDNF,SUPT5H,HDAC6,ASNS,NPC1,ATG4B,TBC1D14,
al_p WAC,MDM2,ZEB1,ATG12,ADSL,CHMP1A,AACS,MEF2A,OXCT1,ERCC
roce 1,NRBP2,NTRK1,ATG3,RRP8,USF1
ss
1.21
102
314
5
interferon-gamma-mediated signaling
pathway
biol
ogic
al_p HLA-DPB1,HLA-C,HLA-DQA1,PTPN6,CAMK2D,NR1H3,HLA-F,IRF9
roce
ss
1.43
708
079
9
9
E
0
1
1.
9
0
E
0
1
1.
9
0
E
0
1
1.
9
1
E
0
1
1.
9
1
E
0
1
G
O:
00
33
23
8
regulation of cellular amine metabolic
process
biol
ogic
al_p PSMB10,PAX8,PSMB9,OAZ1,PSMC6,PSMC4,LPCAT1,PSMA1
roce
ss
1.43
708
079
9
negative regulation of intracellular transport
biol
ogic
al_p FKBP1A,NF1,PKD2,CSK,GOPC,C1QTNF3,MDFI,PKD1
roce
ss
1.43
708
079
9
transcription elongation factor complex
cell
ular
_co SUPT5H,SUPT4H1,PAF1,WDR61
mpo
nent
1.74
916
597
2
G
O:
00
05
63
7
nuclear inner membrane
cell
ular
_co ATP11B,SUN2,LMNB1,LRPPRC
mpo
nent
1.74
916
597
2
G
O:
primary cilium
cell
ular
1.37
189
G
O:
00
32
38
7
G
O:
00
08
02
3
NPHP3,PTPRK,PKD2,PAFAH1B1,TCTN1,RAB8A,RAB10,CC2D2A,TME
M237,PKD1
1.
9
1
E
0
1
1.
9
1
E
0
1
1.
9
2
E
0
1
1.
9
2
E
0
1
1.
9
00
72
37
2
G
O:
00
01
52
5
G
O:
00
16
72
2
G
O:
00
08
53
6
G
O:
00
43
17
5
_co
mpo
nent
angiogenesis
biol
ogic
al_p
roce
ss
oxidoreductase activity, oxidizing metal ions
mol
ecul
ar_f
unct
ion
Ran GTPase binding
mol
ecul
ar_f
unct
ion
RNA polymerase core enzyme binding
mol
ecul
ar_f
unct
ion
488
FZD6,PLCD1,RNH1,LEF1,ADAM8,KRIT1,ZC3H12A,AAMP,STK4,FGFR1
,NF1,COL18A1,NPR1,SLC12A6,IL18,ADAM15,NRP1,PTEN,UBP1,CTSH
,C3,DDAH1,ENG,ITGA5,PDGFRB,COL8A1,RUNX1,SETD2,PTGIS,CLIC
4,NTRK1,GATA2
1.17
472
544
9
CP,MTRR
2.45
577
506
4
RANBP1,RANBP9
2.45
577
506
4
WAC,PAF1
2.45
577
506
4
2
E
0
1
1.
9
3
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
G
O:
00
19
20
6
nucleoside kinase activity
mol
ecul
ar_f
unct
ion
carbon-nitrogen ligase activity, with
glutamine as amido-N-donor
mol
ecul
ar_f
unct
ion
ATPase regulator activity
mol
ecul
ar_f
unct
ion
G
O:
00
48
40
7
G
O:
G
O:
00
16
88
4
G
O:
00
60
59
0
AK5,UCK1
2.45
577
506
4
ASNS,NADSYN1
2.45
577
506
4
DNAJC10,GRPEL2
2.45
577
506
4
platelet-derived growth factor binding
mol
ecul
ar_f
unct
ion
COL2A1,PDGFRB
2.45
577
506
4
tumor necrosis factor-activated receptor
activity
mol
ecul
TNFRSF25,TNFRSF14
2.45
577
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
00
05
03
1
G
O:
00
06
09
1
G
O:
00
04
46
5
G
O:
00
33
54
0
G
O:
00
50
85
7
ar_f
unct
ion
506
4
generation of precursor metabolites and
energy
biol
ogic
al_p
roce
ss
ACADVL,BDNF,TAZ,PRKACA,TXNL1,FDXR,ADCY4,IDH3G,ADSL,GRB
10,IDH1,IQGAP1,NCOR1,FECH,COX7A2L,PHKG2,LEPR,GNB3,DLST,A
TP5A1,NDUFV1,NDUFS2,ARNT,ETFA,GAPDH,GAA,SLC25A6,SDHA,ID
H3B,MLX,ENO4,RAP1B,GSK3A,IGF2,PGM2,PHKG1,SIRT3,SPCS3,UQ
CRH
1.15
479
707
1
lipoprotein lipase activity
mol
ecul
ar_f
unct
ion
FKBP1A,NR1H3,PDGFRB,LMF1
1.74
280
811
fatty acid beta-oxidation using acyl-CoA
oxidase
biol
ogic
al_p ACAA1,HSD17B4
roce
ss
2.44
956
954
4
positive regulation of antigen receptormediated signaling pathway
biol
ogic
al_p PRKCH,PTPRC
roce
ss
2.44
956
954
4
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
G
O:
00
61
43
0
bone trabecula morphogenesis
biol
ogic
al_p THBS3,SEMA4D
roce
ss
2.44
956
954
4
response to vitamin E
biol
ogic
al_p IGF1R,MEF2A
roce
ss
2.44
956
954
4
response to sterol depletion
biol
ogic
al_p LMNA,FBXW7
roce
ss
2.44
956
954
4
G
O:
00
03
21
1
cardiac ventricle formation
biol
ogic
al_p SMARCD3,MEF2A
roce
ss
2.44
956
954
4
G
O:
chemical homeostasis within a tissue
biol
ogic
2.44
956
G
O:
00
33
19
7
G
O:
00
06
99
1
CTSH,LPCAT1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
00
48
87
5
G
O:
00
16
11
4
al_p
roce
ss
954
4
terpenoid biosynthetic process
biol
ogic
al_p FDPS,ALDH1A3
roce
ss
2.44
956
954
4
SMAD protein complex assembly
biol
ogic
al_p FKBP1A,SMAD4
roce
ss
2.44
956
954
4
G
O:
00
00
16
0
phosphorelay signal transduction system
biol
ogic
al_p MMS19,PDE8A
roce
ss
2.44
956
954
4
G
O:
20
00
06
0
positive regulation of protein ubiquitination
involved in ubiquitin-dependent protein
catabolic process
biol
ogic
al_p PTEN,FBXW7
roce
ss
2.44
956
954
4
G
O:
00
07
18
3
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
G
O:
00
72
07
0
loop of Henle development
biol
ogic
al_p PKD2,PKD1
roce
ss
2.44
956
954
4
negative regulation of glucose import
biol
ogic
al_p GRB10,GSK3A
roce
ss
2.44
956
954
4
mRNA cis splicing, via spliceosome
biol
ogic
al_p DDX23,NCBP2
roce
ss
2.44
956
954
4
G
O:
20
00
46
3
positive regulation of excitatory postsynaptic
membrane potential
biol
ogic
al_p PTEN,NLGN2
roce
ss
2.44
956
954
4
G
O:
exploration behavior
biol
ogic
2.44
956
G
O:
00
46
32
5
G
O:
00
45
29
2
NLGN2,ATXN3
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
00
35
64
0
G
O:
20
00
09
5
G
O:
00
43
92
3
G
O:
00
70
58
4
G
O:
00
07
28
9
al_p
roce
ss
954
4
regulation of Wnt receptor signaling
pathway, planar cell polarity pathway
biol
ogic
al_p NPHP3,ANKRD6
roce
ss
2.44
956
954
4
positive regulation by host of viral
transcription
biol
ogic
al_p LEF1,SMARCA4
roce
ss
2.44
956
954
4
mitochondrion morphogenesis
biol
ogic
al_p DNM1L,SSBP1
roce
ss
2.44
956
954
4
spermatid nucleus differentiation
biol
ogic
al_p SRPK1,GOPC
roce
ss
2.44
956
954
4
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
G
O:
00
10
87
0
positive regulation of receptor biosynthetic
process
biol
ogic
al_p HDAC6,NR1H3
roce
ss
2.44
956
954
4
negative regulation of lipase activity
biol
ogic
al_p BICD1,RGS2
roce
ss
2.44
956
954
4
peptidyl-lysine trimethylation
biol
ogic
al_p WDR61,SETD2
roce
ss
2.44
956
954
4
G
O:
00
32
35
4
response to follicle-stimulating hormone
stimulus
biol
ogic
al_p ASNS,TGFBR3
roce
ss
2.44
956
954
4
G
O:
muscle cell fate commitment
biol
ogic
2.44
956
G
O:
00
60
19
2
G
O:
00
18
02
3
TBX2,MEF2A
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
00
42
69
3
G
O:
00
60
89
6
G
O:
00
48
34
0
G
O:
00
36
10
9
G
O:
00
09
40
4
al_p
roce
ss
954
4
neural plate pattern specification
biol
ogic
al_p TBX18,C2CD3
roce
ss
2.44
956
954
4
paraxial mesoderm morphogenesis
biol
ogic
al_p LEF1,FOXC1
roce
ss
2.44
956
954
4
alpha-linolenic acid metabolic process
biol
ogic
al_p ACAA1,HSD17B4
roce
ss
2.44
956
954
4
toxin metabolic process
biol
ogic
al_p PAM,FMO2
roce
ss
2.44
956
954
4
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
1.
9
4
E
0
1
G
O:
19
00
18
0
regulation of protein localization to nucleus
biol
ogic
RBPMS,DDX58,NF1,PKD2,FLCN,SMAD4,C1QTNF3,FLNA,GLI3,MDFI,P
al_p
KD1,KPNA1,UBR5
roce
ss
1.30
704
643
6
regulation of myeloid cell differentiation
biol
ogic
LEF1,PAF1,NF1,MITF,RB1,MEF2A,CDK6,WDR61,ARNT,RUNX1,ACIN1,
al_p
ZBTB16,GATA2
roce
ss
1.30
704
643
6
regulation of cardiac muscle tissue growth
biol
ogic
al_p TBX2,FGFR1,MEF2A,GSK3A
roce
ss
1.73
840
419
3
G
O:
00
14
90
9
smooth muscle cell migration
biol
ogic
al_p AAMP,NRP1,NOX4,PDGFRB
roce
ss
1.73
840
419
3
G
O:
regulation of glycogen metabolic process
biol
ogic
1.73
840
G
O:
00
45
63
7
G
O:
00
55
02
1
GRB10,PHKG2,GSK3A,IGF2
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
00
70
87
3
G
O:
00
32
23
3
G
O:
00
10
90
7
G
O:
00
70
22
8
G
O:
00
46
58
0
al_p
roce
ss
419
3
positive regulation of actin filament bundle
assembly
biol
ogic
al_p PPM1F,PAK1,FHOD1,NOX4
roce
ss
1.73
840
419
3
positive regulation of glucose metabolic
process
biol
ogic
al_p SMEK1,PHKG2,ARNT,IGF2
roce
ss
1.73
840
419
3
regulation of lymphocyte apoptotic process
biol
ogic
al_p NOC2L,BCL6,ADAM8,PTEN
roce
ss
1.73
840
419
3
negative regulation of Ras protein signal
transduction
biol
ogic
al_p BCL6,NF1,FLCN,DGKZ
roce
ss
1.73
840
419
3
5
E
0
1
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
5
E
0
1
G
O:
00
01
51
0
RNA methylation
biol
ogic
al_p METTL3,WDR4,TGS1,FTSJ3
roce
ss
1.73
840
419
3
centrosome duplication
biol
ogic
al_p CEP135,PKD2,PLK2,CDK5RAP2
roce
ss
1.73
840
419
3
mRNA export from nucleus
biol
ogic
al_p DDX39A,UPF1,FYTTD1,SRSF10,THOC2,NCBP2,PABPN1
roce
ss
1.47
356
917
9
G
O:
19
00
27
4
regulation of phospholipase C activity
biol
ogic
al_p PRKACA,FGFR1,ADCY4,CREB1,BICD1,PDGFRB,NTRK1
roce
ss
1.47
356
917
9
G
O:
adherens junction organization
biol
ogic
1.39
372
G
O:
00
51
29
8
G
O:
00
06
40
6
CADM1,SMAD7,PPM1F,PTPRK,PTEN,PXN,CSK,TBCD,PDPK1
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
5
E
0
1
1.
9
00
34
33
2
G
O:
00
43
90
2
G
O:
00
05
63
5
G
O:
00
18
13
0
al_p
roce
ss
060
3
positive regulation of multi-organism
process
biol
ogic
SUPT5H,VAPB,LEF1,SUPT4H1,RAD23A,IFITM3,SRPK1,NCBP2,SMAR
al_p
CA4
roce
ss
1.39
372
060
3
nuclear envelope
cell
ular
_co
mpo
nent
1.19
186
072
5
heterocycle biosynthetic process
FZD6,PBX2,KANK2,GTF3C2,RAI1,PTS,SIRT2,MYNN,NOC2L,RAF1,ZN
F131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20H,PWP1
,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,CUX1,EED,SMAD7,MCF2
L,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,EMX2
biol ,RBPMS,ZSCAN31,XBP1,PAM,APITD1,USP47,ADAM8,POLR3E,GABP
ogic B1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,STAT2,PLK1,ZNF44
al_p 6,PNPO,PTGES2,ZNF621,HDGF,PPP5C,CCNL1,CHD6,ZC3H12A,SLC1
roce 1A2,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHD
ss
M1D,ZNF710,WAC,ZNF142,FUBP3,ZNF540,ALDH18A1,FGFR1,HSF4,G
TF3C1,NADSYN1,ADCY4,PAF1,TAB2,SGK1,DPF2,NADK,MDM2,PRKC
H,PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,FLII,RPRD1
A,DDX58,RPL27,CCNL2,PTPRK,NF1,ZEB1,IFITM3,ASCC2,RGMB,EBF
1,RPL9,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,ADSL,BRD9,ZNF837,PKD
SLC16A3,CBX5,NUP98,IL15RA,RANBP1,NUTF2,NPC1,SHISA5,NUP21
0,LMNA,PAFAH1B1,SENP2,SYNE1,KPNB1,ATP11B,OSBPL3,NUP37,P
AK1,GOLPH3,CDC14B,SUN2,NUP85,LMNB1,LRPPRC,WDFY3,BNIP2,
KPNA1
1.04
425
291
3
6
E
0
1
1.
9
6
E
0
1
1.
9
6
E
0
1
1.
9
6
E
0
1
2,RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,ZNF865,SEN
P2,SUB1,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR
1H3,GARS,USP7,FLCN,ZNF605,ZNF410,GMDS,RPL24,RPL37A,SAP30
BP,VPS72,PTEN,RNASEK,RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,R
QCD1,RFX7,NCOR1,PPP1R10,MEF2A,FECH,SETD8,PIAS2,MAPK8,M
YCBP2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CD
K5RAP2,IMPDH1,UBP1,WDR61,EBF4,ZNF148,ZNF76,SP110,NCK2,TC
F4,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,NFYC,SRSF10,SS18,RCOR3
,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF44,CREBZF,
ING4,ZNF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,ATP5A1,GLI3,MAP
K12,CCDC59,DCAF6,AK5,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,Z
NF692,PHF1,STK36,WWP1,PHF12,MED6,MDFI,ZNF554,HINFP,NCBP2
,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,SMARCA4,N
AA16,LRPPRC,RPLP0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3
,GSK3A,SNRPE,ZNF383,POLR2J3,NCOR2,FPGS,SETD2,IGF2,PTGIS,
TROVE2,ATXN3,PHF21A,GPHN,PDCD4,SOX13,CHD2,STAT6,ZNF138,
ZNF705A,NTRK1,TFAM,BRWD1,SMAD9,TGFBR3,ZBTB16,BAZ2A,UCK
1,RRP8,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,CDK5RAP
3,PANK3,EYA2,SMARCAD1,CC2D1A,GATA2,PABPN1
G
O:
00
01
94
4
G
O:
00
06
44
vasculature development
biol
ogic
al_p
roce
ss
FZD6,PLCD1,TBX2,SMAD7,RNH1,LEF1,ADAM8,KRIT1,ZC3H12A,AAM
P,STK4,FGFR1,NF1,COL18A1,NPR1,PKD2,SLC12A6,ZFPM2,IL18,ADA
M15,NRP1,PTEN,FBXW7,MEF2A,MYLK,UBP1,CTSH,C3,DDAH1,GLI3,E
NG,ITGA5,PDGFRB,COL8A1,RUNX1,SMARCA4,SETD2,PTGIS,MYO1E
,CLIC4,NTRK1,TGFBR3,PKD1,FOXC1,GATA2
regulation of translational initiation
biol
ogic
al_p EIF2B4,FMR1,UHMK1,EIF4B,FECH,NCBP2
roce
ss
1.13
960
237
3
1.52
520
367
9
1.
9
8
E
0
1
1.
9
8
E
-
6
G
O:
00
51
05
2
regulation of DNA metabolic process
biol
ogic OBFC1,IGF1R,BCL6,RNF8,INO80,RNF168,FBXW7,TRIM28,PTPRC,ST
al_p AG2,ACD,NOX4,ERCC1,CIZ1,PDGFRB,STAT6,KPNA1,UBR5,SMARCA
roce D1
ss
1.23
661
844
1
regulation of tissue remodeling
biol
ogic
al_p ADAM8,NF1,IL18,CSK,CSF1R
roce
ss
1.60
388
482
1
regulation of DNA recombination
biol
ogic
al_p BCL6,PTPRC,STAT6,KPNA1,SMARCAD1
roce
ss
1.60
388
482
1
G
O:
20
01
25
1
negative regulation of chromosome
organization
biol
ogic
al_p NOC2L,ACD,ERCC1,PHF1,UBR5
roce
ss
1.60
388
482
1
G
O:
regulation of epithelial to mesenchymal
transition
biol
ogic
1.60
388
G
O:
00
34
10
3
G
O:
00
00
01
8
SMAD7,LEF1,SMAD4,TGFB1I1,TGFBR3
0
1
1.
9
8
E
0
1
1.
9
8
E
0
1
1.
9
8
E
0
1
1.
9
8
E
0
1
1.
9
00
10
71
7
G
O:
00
61
00
5
G
O:
00
06
33
8
G
O:
00
09
05
5
G
O:
00
60
24
9
al_p
roce
ss
482
1
cell differentiation involved in kidney
development
biol
ogic
al_p PAX8,IQGAP1,MEF2A,GLI3,MYO1E
roce
ss
1.60
388
482
1
chromatin remodeling
biol
ogic
SUPT5H,SUPT4H1,CHD6,RNF8,INO80,RB1,SMARCD3,SMARCA4,BAZ
al_p
2A,SMARCAD1
roce
ss
1.36
087
196
9
electron carrier activity
mol
ecul
ar_f
unct
ion
1.27
422
291
anatomical structure homeostasis
biol
ogic
OBFC1,COL9A1,COL2A1,ADAM8,BBS1,GIGYF2,NF1,TPP1,CSK,CTSH,
al_p
ACD,CSF1R,NOX4,ERCC1,GAA,LPCAT1,PDGFRB,GATA2
roce
ss
DNAJC10,TXNL1,PTGES2,CYP2R1,QSOX1,TXNDC5,COX7A2L,P4HB,
NDUFS2,NOX4,ETFA,PDIA5,IDH3B,PDIA3,PTGIS
1.24
362
761
5
8
E
0
1
1.
9
8
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
G
O:
00
51
25
2
regulation of RNA metabolic process
FZD6,PBX2,KANK2,RAI1,SIRT2,MYNN,NOC2L,ZNF131,RSC1A1,SFSW
AP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20H,BCL6,FUBP1,ZNF783,TBX
2,MMS19,CUX1,EED,SMAD7,MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,
LEF1,PAX8,SUPT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PAM,SNR
NP70,USP47,ADAM8,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,
NOD1,STAT2,PLK1,ZNF446,PTGES2,ZNF621,HDGF,CCNL1,CHD6,ZC
3H12A,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JH
DM1D,ZNF710,WAC,ZNF142,FUBP3,ZNF540,FGFR1,HSF4,CELF1,PAF
1,TAB2,SGK1,DPF2,MDM2,PRKCH,PPM1F,ZNF595,TBP,YY1,INO80,G
MEB2,PFDN5,CREB1,FLII,RPRD1A,DDX58,CCNL2,PTPRK,ZEB1,IFITM
3,ASCC2,RGMB,EBF1,MED28,ZNF3,RPS6KA5,NIPBL,BRD9,ZNF837,P
KD2,RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,ZNF865,S
biol ENP2,SUB1,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,
ogic NR1H3,USP7,FLCN,ZNF605,ZNF410,SAP30BP,VPS72,PTEN,SRPK1,R
al_p UNX2,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,MEF2A,SETD8,
roce PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TR
ss
IM28,DMTF1,CDK5RAP2,UBP1,WDR61,EBF4,ZNF148,ZNF76,SP110,N
CK2,TCF4,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,NFYC,SRSF10,SS18,
RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,ZNF44,CREBZF,ING4,ZNF687,
CLK3,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,MAPK12,CCDC59,DC
AF6,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,ZNF692,PHF1,STK36,WWP1,
PHF12,MED6,MDFI,ZNF554,HINFP,NCBP2,MLX,TGS1,CDK11A,GLIS3,
ELP6,BDP1,RUNX1,SMARCA4,NAA16,LRPPRC,RAD54L2,ZNF518B,CL
K4,ZNF90,ZNF638,PER3,ZNF383,NCOR2,SETD2,IGF2,PTGIS,ATXN3,
PHF21A,PDCD4,SOX13,CHD2,STAT6,SON,ZNF138,ZNF705A,NTRK1,T
FAM,BRWD1,SMAD9,TGFBR3,ZBTB16,BAZ2A,RRP8,PHF19,LMCD1,P
KD1,PDPK1,TSG101,USF1,FOXC1,CDK5RAP3,PABPC1,FASTK,EYA2,
SMARCAD1,CC2D1A,GATA2
G
LUBAC complex
cell
SHARPIN
1.04
796
203
1
1.
9
9
E
0
1
4.66
1.
O:
00
71
79
7
G
O:
00
34
67
3
G
O:
00
71
06
2
G
O:
00
05
84
6
G
O:
00
43
25
ular
_co
mpo
nent
444
259
1
inhibin-betaglycan-ActRII complex
cell
ular
_co TGFBR3
mpo
nent
4.66
444
259
1
alphav-beta3 integrin-vitronectin complex
cell
ular
_co ITGA5
mpo
nent
4.66
444
259
1
nuclear cap binding complex
cell
ular
_co NCBP2
mpo
nent
4.66
444
259
1
laminin-10 complex
cell
ular
_co LAMB1
mpo
nent
4.66
444
259
1
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
-
9
G
O:
00
71
82
1
FANCM-MHF complex
cell
ular
_co APITD1
mpo
nent
4.66
444
259
1
endoplasmic reticulum tubular network
cell
ular
_co RAB10
mpo
nent
4.66
444
259
1
perichromatin fibrils
cell
ular
_co SMARCA4
mpo
nent
4.66
444
259
1
G
O:
00
31
83
8
haptoglobin-hemoglobin complex
cell
ular
_co HBB
mpo
nent
4.66
444
259
1
G
O:
GARP complex
cell
ular
4.66
444
G
O:
00
71
78
2
G
O:
00
05
72
6
VPS51
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
00
00
93
8
G
O:
00
34
66
3
G
O:
00
30
43
0
G
O:
00
44
53
0
G
O:
00
14
80
2
_co
mpo
nent
259
1
endoplasmic reticulum chaperone complex
cell
ular
_co DNAJC10
mpo
nent
4.66
444
259
1
host cell cytoplasm
cell
ular
_co BICD1
mpo
nent
4.66
444
259
1
supraspliceosomal complex
cell
ular
_co UPF1
mpo
nent
4.66
444
259
1
terminal cisterna
cell
ular
_co FKBP1A
mpo
nent
4.66
444
259
1
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
G
O:
00
17
10
1
aminoacyl-tRNA synthetase multienzyme
complex
cell
ular
_co RARS
mpo
nent
4.66
444
259
1
signal recognition particle receptor complex
cell
ular
_co SRP9
mpo
nent
4.66
444
259
1
Stn1-Ten1 complex
cell
ular
_co OBFC1
mpo
nent
4.66
444
259
1
G
O:
00
45
29
8
tubulin complex
cell
ular
_co BICD1
mpo
nent
4.66
444
259
1
G
O:
activin responsive factor complex
cell
ular
4.66
444
G
O:
00
05
78
5
G
O:
00
70
18
8
SMAD4
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
00
32
44
4
G
O:
00
97
05
8
G
O:
00
00
94
2
G
O:
00
32
29
9
G
O:
00
33
65
5
_co
mpo
nent
259
1
CRLF-CLCF1 complex
cell
ular
_co CNTF
mpo
nent
4.66
444
259
1
condensed nuclear chromosome outer
kinetochore
cell
ular
_co PLK1
mpo
nent
4.66
444
259
1
ribonuclease H2 complex
cell
ular
_co RNASEH2B
mpo
nent
4.66
444
259
1
host cell cytoplasm part
cell
ular
_co BICD1
mpo
nent
4.66
444
259
1
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
1.
9
9
E
0
1
G
O:
00
16
60
0
flotillin complex
cell
ular
_co FLOT1
mpo
nent
4.66
444
259
1
signal peptidase complex
cell
ular
_co SPCS3
mpo
nent
4.66
444
259
1
threonine-type peptidase activity
mol
ecul
ar_f
unct
ion
PSMB10,PSMB9,PSMA1
1.92
953
755
G
O:
00
42
80
5
actinin binding
mol
ecul
ar_f
unct
ion
PDLIM5,MAGI1,PKD2
1.92
953
755
G
O:
threonine-type endopeptidase activity
mol
ecul
PSMB10,PSMB9,PSMA1
1.92
953
G
O:
00
05
78
7
G
O:
00
70
00
3
1.
9
9
E
0
1
1.
9
9
E
0
1
2.
0
0
E
0
1
2.
0
0
E
0
1
2.
0
00
04
29
8
G
O:
00
08
65
6
G
O:
00
05
21
9
G
O:
00
48
36
5
G
O:
00
16
92
2
ar_f
unct
ion
755
cysteine-type endopeptidase activator
activity involved in apoptotic process
mol
ecul
ar_f
unct
ion
NLRP1,BCL2L13,NOD1
1.92
953
755
ryanodine-sensitive calcium-release
channel activity
mol
ecul
ar_f
unct
ion
CAMK2D,FKBP1A,PKD2
1.92
953
755
Rac GTPase binding
mol
ecul
ar_f
unct
ion
IQGAP1,SRGAP2,FLNA
1.92
953
755
ligand-dependent nuclear receptor binding
mol
ecul
ar_f
unct
ion
SMARCD3,NCOR2,BAZ2A
1.92
953
755
0
E
0
1
2.
0
0
E
0
1
2.
0
0
E
0
1
2.
0
0
E
0
1
2.
0
0
E
0
1
G
O:
00
16
89
6
exoribonuclease activity, producing 5phosphomonoesters
mol
ecul
ar_f
unct
ion
DIS3L,PAN2,PARN
1.92
953
755
phosphatidylinositol 3-kinase binding
mol
ecul
ar_f
unct
ion
IGF1R,FYN,PDGFRB
1.92
953
755
cytoplasmic vesicle part
cell
ular
_co
mpo
nent
CPE,RAB34,HLA-DPB1,IL15RA,SYTL4,HLA-C,PAM,HLADQA1,AP3S2,ADAM8,CD9,VAMP7,CAMK2D,TNK2,SEC31A,MDM2,MC
FD2,SNX21,RAB31,EPN2,SNX17,CLTCL1,HLAF,RAB8A,DENND4C,CLTB,RAB10,ATP6V0A1,TMED3,TMED2,VPS51,C
LIC4,SEC31B,ZDHHC8,CD63
1.16
058
405
7
G
O:
00
02
06
2
chondrocyte differentiation
biol
ogic
al_p COL2A1,GLG1,FGFR1,RUNX2,MEF2A,GLI3,ZBTB16,ACAN
roce
ss
1.41
817
184
1
G
O:
negative regulation of protein kinase B
signaling cascade
biol
ogic
1.92
466
G
O:
00
43
54
8
G
O:
00
44
43
3
IGF1R,FLCN,PTEN
2.
0
0
E
0
1
2.
0
0
E
0
1
2.
0
1
E
0
1
2.
0
1
E
0
1
2.
0
00
51
89
8
G
O:
00
72
13
2
G
O:
00
51
32
0
G
O:
00
42
80
3
G
O:
00
35
25
8
al_p
roce
ss
178
5
mesenchyme morphogenesis
biol
ogic
al_p TBX2,SMAD4,ENG
roce
ss
1.92
466
178
5
S phase
biol
ogic
PSMB10,BCL6,PSMB9,GIGYF2,PAF1,INO80,RB1,CHMP1A,CUL4A,PTP
al_p
RC,PSMC6,PSMC4,SMARCA4,PSMA1
roce
ss
1.28
310
785
7
protein homodimerization activity
mol
ecul
ar_f
unct
ion
CRBN,CADM1,PTS,EPHX2,TARS,DPP4,VAPB,NOD1,ASNS,PDXK,TBX
18,STK4,FGFR1,HPS4,RNF8,PKD2,MZF1,PAFAH1B1,CALCOCO2,SYN
E1,PLD6,FAP,ALDH1A3,IDH1,SRGAP2,MEF2A,OXCT1,MYCBP2,GOPC
,CSF1R,HSD17B4,ROBO3,SMAD4,GRPEL2,TBC1D22A,FLNA,SDCBP2
,ENG,EXT1,MLX,RUNX1,SUMF2,KLHL7,PCYT1A,NTRK1,ZBTB16,USF
1,TENM4
1.13
145
657
4
steroid hormone receptor binding
mol
ecul
ar_f
unct
ion
MMS19,LEF1,RB1,PIAS2,TGFB1I1,SMARCA4,NCOR2
1.45
457
446
1
1
E
0
1
2.
0
1
E
0
1
2.
0
2
E
0
1
2.
0
2
E
0
1
2.
0
4
E
0
1
G
O:
00
22
60
4
regulation of cell morphogenesis
biol
ogic SMAD7,LEF1,PAX8,CAPZB,PRPF40A,SIPA1L1,PDLIM5,ACTR3,CAPRI
al_p N1,SSH2,PAFAH1B1,ARPC2,NRP1,PTEN,FYN,SEMA4D,CSF1R,SMAD
roce 4,TGFB1I1,EZR,PTPRD,KIF13B,ROBO2,BRWD1,TGFBR3,STK24,SSH1
ss
1.18
488
950
3
induction of apoptosis
biol
ogic NLRP1,PPP1R13B,CASP4,LEF1,BCL2L13,BCL2L11,NOD1,SHISA5,BC
al_p LAF1,STK4,DPF2,TNFRSF25,DFNA5,CASP2,SAP30BP,PTEN,DIABLO,
roce STK24
ss
1.23
728
257
6
positive regulation of protein import into
nucleus
biol
ogic
al_p RBPMS,DDX58,SMAD4,FLNA,GLI3,KPNA1,UBR5
roce
ss
1.45
089
888
4
G
O:
00
45
74
4
negative regulation of G-protein coupled
receptor protein signaling pathway
biol
ogic
al_p ARHGEF12,SNX13,BICD1,RGS3,RGS2,ADRBK2,SNX14
roce
ss
1.45
089
888
4
G
O:
centrosome organization
biol
ogic
1.45
089
G
O:
00
06
91
7
G
O:
00
42
30
7
CEP135,RANBP1,PLK1,PKD2,PLK2,CDK5RAP2,HAUS5
2.
0
4
E
0
1
2.
0
5
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
00
51
29
7
G
O:
00
04
69
9
G
O:
00
42
57
7
G
O:
00
51
73
3
G
O:
00
04
47
6
al_p
roce
ss
calcium-independent protein kinase C
activity
mol
ecul
ar_f
unct
ion
lipid phosphatase activity
mol
ecul
ar_f
unct
ion
polydeoxyribonucleotide kinase activity
mol
ecul
ar_f
unct
ion
mannose-6-phosphate isomerase activity
mol
ecul
ar_f
unct
ion
888
4
PRKCH
4.50
225
428
3
EPHX2
4.50
225
428
3
PNKP
4.50
225
428
3
SPATA20
4.50
225
428
3
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
G
O:
00
16
50
8
long-chain-enoyl-CoA hydratase activity
mol
ecul
ar_f
unct
ion
insulin-like growth factor-activated receptor
activity
mol
ecul
ar_f
unct
ion
succinyltransferase activity
mol
ecul
ar_f
unct
ion
G
O:
00
19
79
7
G
O:
G
O:
00
05
01
0
G
O:
00
16
74
8
HSD17B4
4.50
225
428
3
IGF1R
4.50
225
428
3
DLST
4.50
225
428
3
procollagen-proline 3-dioxygenase activity
mol
ecul
ar_f
unct
ion
LEPRE1
4.50
225
428
3
ATP-dependent polynucleotide kinase
activity
mol
ecul
PNKP
4.50
225
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
00
51
73
4
G
O:
00
47
37
4
G
O:
00
17
16
2
G
O:
00
04
92
4
G
O:
00
08
96
9
ar_f
unct
ion
methylumbelliferyl-acetate deacetylase
activity
mol
ecul
ar_f
unct
ion
aryl hydrocarbon receptor binding
mol
ecul
ar_f
unct
ion
oncostatin-M receptor activity
mol
ecul
ar_f
unct
ion
phosphohistidine phosphatase activity
mol
ecul
ar_f
unct
ion
428
3
CES2
4.50
225
428
3
ARNT
4.50
225
428
3
LIFR
4.50
225
428
3
PHPT1
4.50
225
428
3
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
G
O:
00
04
82
9
threonine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
alpha-N-acetylgalactosaminide alpha-2,6sialyltransferase activity
mol
ecul
ar_f
unct
ion
maltose alpha-glucosidase activity
mol
ecul
ar_f
unct
ion
G
O:
00
08
10
9
G
O:
G
O:
00
01
66
5
G
O:
00
32
45
0
TARS
4.50
225
428
3
ST6GALNAC5
4.50
225
428
3
GAA
4.50
225
428
3
N-acetyllactosaminide beta-1,6-Nacetylglucosaminyltransferase activity
mol
ecul
ar_f
unct
ion
GCNT2
4.50
225
428
3
natriuretic peptide receptor activity
mol
ecul
NPR1
4.50
225
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
00
16
94
1
G
O:
00
35
47
3
G
O:
00
05
17
3
G
O:
00
34
58
4
G
O:
00
31
54
4
ar_f
unct
ion
lipase binding
mol
ecul
ar_f
unct
ion
stem cell factor receptor binding
mol
ecul
ar_f
unct
ion
piRNA binding
mol
ecul
ar_f
unct
ion
peptidyl-proline 3-dioxygenase activity
mol
ecul
ar_f
unct
ion
428
3
LRPAP1
4.50
225
428
3
SPRED1
4.50
225
428
3
PIWIL4
4.50
225
428
3
LEPRE1
4.50
225
428
3
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
G
O:
00
16
14
9
translation release factor activity, codon
specific
mol
ecul
ar_f
unct
ion
fatty acid elongase activity
mol
ecul
ar_f
unct
ion
long-chain-acyl-CoA dehydrogenase activity
mol
ecul
ar_f
unct
ion
G
O:
00
08
38
4
G
O:
G
O:
00
09
92
2
G
O:
00
04
46
6
MTRF1L
4.50
225
428
3
ELOVL1
4.50
225
428
3
ACADVL
4.50
225
428
3
IkappaB kinase activity
mol
ecul
ar_f
unct
ion
IKBKB
4.50
225
428
3
glucuronosyl-N-acetylglucosaminylproteoglycan 4-alpha-N-
mol
ecul
EXT1
4.50
225
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
00
50
50
8
G
O:
00
42
89
5
G
O:
00
43
39
8
G
O:
00
10
46
5
G
O:
00
35
51
4
acetylglucosaminyltransferase activity
ar_f
unct
ion
antibiotic transporter activity
mol
ecul
ar_f
unct
ion
HLH domain binding
mol
ecul
ar_f
unct
ion
nerve growth factor receptor activity
mol
ecul
ar_f
unct
ion
DNA demethylase activity
mol
ecul
ar_f
unct
ion
428
3
MFSD10
4.50
225
428
3
PKD2
4.50
225
428
3
NTRK1
4.50
225
428
3
ALKBH3
4.50
225
428
3
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
G
O:
00
04
99
2
platelet activating factor receptor activity
mol
ecul
ar_f
unct
ion
phosphotransferase activity, carboxyl group
as acceptor
mol
ecul
ar_f
unct
ion
asialoglycoprotein receptor activity
mol
ecul
ar_f
unct
ion
G
O:
00
30
34
3
G
O:
G
O:
00
16
77
4
G
O:
00
04
87
3
PDGFRB
4.50
225
428
3
ALDH18A1
4.50
225
428
3
LRPAP1
4.50
225
428
3
vitamin D3 25-hydroxylase activity
mol
ecul
ar_f
unct
ion
CYP2R1
4.50
225
428
3
iron-responsive element binding
mol
ecul
FECH
4.50
225
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
00
30
35
0
G
O:
00
15
01
8
G
O:
00
04
56
6
G
O:
00
46
97
6
G
O:
00
38
08
5
ar_f
unct
ion
galactosylgalactosylxylosylprotein 3-betaglucuronosyltransferase activity
mol
ecul
ar_f
unct
ion
beta-glucuronidase activity
mol
ecul
ar_f
unct
ion
histone methyltransferase activity (H3-K27
specific)
mol
ecul
ar_f
unct
ion
vascular endothelial growth factor binding
mol
ecul
ar_f
unct
ion
428
3
B3GAT3
4.50
225
428
3
GUSB
4.50
225
428
3
EHMT1
4.50
225
428
3
PDGFRB
4.50
225
428
3
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
G
O:
00
05
01
7
platelet-derived growth factor-activated
receptor activity
mol
ecul
ar_f
unct
ion
vitamin D 25-hydroxylase activity
mol
ecul
ar_f
unct
ion
immunoglobulin receptor binding
mol
ecul
ar_f
unct
ion
G
O:
20
01
07
0
G
O:
G
O:
00
70
64
3
G
O:
00
34
98
7
PDGFRB
4.50
225
428
3
CYP2R1
4.50
225
428
3
FLNA
4.50
225
428
3
starch binding
mol
ecul
ar_f
unct
ion
GPCPD1
4.50
225
428
3
DNA-N1-methyladenine dioxygenase
activity
mol
ecul
ALKBH3
4.50
225
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
00
43
73
4
G
O:
00
00
02
6
G
O:
00
08
51
0
G
O:
00
04
81
4
G
O:
00
16
97
2
ar_f
unct
ion
alpha-1,2-mannosyltransferase activity
mol
ecul
ar_f
unct
ion
sodium:bicarbonate symporter activity
mol
ecul
ar_f
unct
ion
arginine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
thiol oxidase activity
mol
ecul
ar_f
unct
ion
428
3
ALG9
4.50
225
428
3
SLC4A4
4.50
225
428
3
RARS
4.50
225
428
3
QSOX1
4.50
225
428
3
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
G
O:
00
08
47
5
procollagen-lysine 5-dioxygenase activity
mol
ecul
ar_f
unct
ion
oxygen sensor activity
mol
ecul
ar_f
unct
ion
Ral GTPase activator activity
mol
ecul
ar_f
unct
ion
G
O:
00
08
97
0
G
O:
G
O:
00
19
82
6
G
O:
00
17
12
3
PLOD2
4.50
225
428
3
NOX4
4.50
225
428
3
RALGAPA2
4.50
225
428
3
phosphatidylcholine 1-acylhydrolase activity
mol
ecul
ar_f
unct
ion
PLA2G16
4.50
225
428
3
ornithine decarboxylase inhibitor activity
mol
ecul
OAZ1
4.50
225
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
00
08
07
3
G
O:
00
70
73
5
G
O:
00
04
88
6
G
O:
00
46
40
4
G
O:
00
16
40
1
ar_f
unct
ion
protein-glycine ligase activity
mol
ecul
ar_f
unct
ion
9-cis retinoic acid receptor activity
mol
ecul
ar_f
unct
ion
ATP-dependent polydeoxyribonucleotide 5hydroxyl-kinase activity
mol
ecul
ar_f
unct
ion
palmitoyl-CoA oxidase activity
mol
ecul
ar_f
unct
ion
428
3
TTLL3
4.50
225
428
3
RXRB
4.50
225
428
3
PNKP
4.50
225
428
3
ACAA1
4.50
225
428
3
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
2.
0
6
E
0
1
G
O:
00
06
39
1
transcription initiation from mitochondrial
promoter
biol
ogic
al_p TFAM
roce
ss
4.49
087
749
8
regulation of exocyst localization
biol
ogic
al_p RALGAPA2
roce
ss
4.49
087
749
8
VEGF-activated platelet-derived growth
factor receptor signaling pathway
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
G
O:
20
00
61
1
positive regulation of thyroid hormone
generation
biol
ogic
al_p PAX8
roce
ss
4.49
087
749
8
G
O:
activation of membrane attack complex
biol
ogic
4.49
087
G
O:
00
60
17
8
G
O:
00
38
08
6
C3
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
01
90
5
G
O:
19
01
14
2
G
O:
00
00
05
4
G
O:
19
00
22
2
G
O:
00
60
68
9
al_p
roce
ss
749
8
insulin metabolic process
biol
ogic
al_p CPE
roce
ss
4.49
087
749
8
ribosomal subunit export from nucleus
biol
ogic
al_p SDAD1
roce
ss
4.49
087
749
8
negative regulation of beta-amyloid
clearance
biol
ogic
al_p LRPAP1
roce
ss
4.49
087
749
8
cell differentiation involved in salivary gland
development
biol
ogic
al_p XBP1
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
01
96
9
regulation of activation of membrane attack
complex
biol
ogic
al_p C3
roce
ss
4.49
087
749
8
negative regulation of cell proliferation
involved in contact inhibition
biol
ogic
al_p PAK1
roce
ss
4.49
087
749
8
ribonucleoside diphosphate biosynthetic
process
biol
ogic
al_p AK5
roce
ss
4.49
087
749
8
G
O:
00
70
16
2
adiponectin secretion
biol
ogic
al_p C1QTNF3
roce
ss
4.49
087
749
8
G
O:
protein polyglycylation
biol
ogic
4.49
087
G
O:
00
60
24
4
G
O:
00
09
18
8
TTLL3
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
18
09
4
G
O:
00
72
27
7
G
O:
00
33
75
3
G
O:
00
42
07
8
G
O:
00
71
63
8
al_p
roce
ss
749
8
metanephric glomerular capillary formation
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
establishment of ribosome localization
biol
ogic
al_p SDAD1
roce
ss
4.49
087
749
8
germ-line stem cell division
biol
ogic
al_p ZBTB16
roce
ss
4.49
087
749
8
negative regulation of monocyte
chemotactic protein-1 production
biol
ogic
al_p C1QTNF3
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
20
00
65
9
regulation of interleukin-1-mediated
signaling pathway
biol
ogic
al_p VRK2
roce
ss
4.49
087
749
8
regulation of transcription from RNA
polymerase II promoter by glucose
biol
ogic
al_p USF1
roce
ss
4.49
087
749
8
regulation of hair follicle cell proliferation
biol
ogic
al_p RUNX1
roce
ss
4.49
087
749
8
G
O:
19
00
04
4
regulation of protein K63-linked
ubiquitination
biol
ogic
al_p UBR5
roce
ss
4.49
087
749
8
G
O:
cellular response to salt stress
biol
ogic
4.49
087
G
O:
00
00
43
0
G
O:
00
71
33
6
SLC12A6
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
71
47
2
G
O:
00
72
67
2
G
O:
00
61
01
0
G
O:
00
60
44
8
G
O:
00
06
93
3
al_p
roce
ss
749
8
neutrophil extravasation
biol
ogic
al_p ADAM8
roce
ss
4.49
087
749
8
gall bladder development
biol
ogic
al_p NIPBL
roce
ss
4.49
087
749
8
dichotomous subdivision of terminal units
involved in lung branching
biol
ogic
al_p CTSH
roce
ss
4.49
087
749
8
negative regulation of cell adhesion
involved in substrate-bound cell migration
biol
ogic
al_p PTPRC
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
70
27
2
proton-transporting ATP synthase complex
biogenesis
biol
ogic
al_p ATPAF2
roce
ss
4.49
087
749
8
negative regulation of protein kinase activity
by regulation of protein phosphorylation
biol
ogic
al_p PPM1F
roce
ss
4.49
087
749
8
nitric oxide transport
biol
ogic
al_p HBB
roce
ss
4.49
087
749
8
G
O:
00
36
30
2
atrioventricular canal development
biol
ogic
al_p TBX2
roce
ss
4.49
087
749
8
G
O:
box C/D snoRNP assembly
biol
ogic
4.49
087
G
O:
00
44
38
7
G
O:
00
30
18
5
PIH1D1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
00
49
2
G
O:
00
35
79
3
G
O:
00
01
79
4
G
O:
00
32
69
6
G
O:
00
51
03
0
al_p
roce
ss
749
8
positive regulation of metanephric
mesenchymal cell migration by plateletderived growth factor receptor-beta
signaling pathway
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
type IIa hypersensitivity
biol
ogic
al_p C3
roce
ss
4.49
087
749
8
negative regulation of interleukin-13
production
biol
ogic
al_p LEF1
roce
ss
4.49
087
749
8
snRNA transport
biol
ogic
al_p NCBP2
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
20
00
01
7
positive regulation of determination of
dorsal identity
biol
ogic
al_p MAPK8
roce
ss
4.49
087
749
8
ventricular zone neuroblast division
biol
ogic
al_p FGFR1
roce
ss
4.49
087
749
8
positive regulation of type II hypersensitivity
biol
ogic
al_p C3
roce
ss
4.49
087
749
8
G
O:
00
71
40
2
cellular response to lipoprotein particle
stimulus
biol
ogic
al_p NPC1
roce
ss
4.49
087
749
8
G
O:
male germ-line stem cell division
biol
ogic
4.49
087
G
O:
00
21
84
7
G
O:
00
02
89
4
ZBTB16
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
48
13
3
G
O:
00
43
58
5
al_p
roce
ss
749
8
nose morphogenesis
biol
ogic
al_p GLI3
roce
ss
4.49
087
749
8
DNA methylation on cytosine within a CG
sequence
biol
ogic
al_p SMARCA4
roce
ss
4.49
087
749
8
G
O:
00
72
00
3
kidney rudiment formation
biol
ogic
al_p PAX8
roce
ss
4.49
087
749
8
G
O:
00
38
09
1
positive regulation of cell proliferation by
VEGF-activated platelet derived growth
factor receptor signaling pathway
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
G
O:
00
10
42
4
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
20
00
98
3
regulation of ATP citrate synthase activity
biol
ogic
al_p PHPT1
roce
ss
4.49
087
749
8
plasma cell differentiation
biol
ogic
al_p LGALS8
roce
ss
4.49
087
749
8
L-lysine catabolic process to acetyl-CoA via
saccharopine
biol
ogic
al_p DLST
roce
ss
4.49
087
749
8
G
O:
00
72
24
0
metanephric DCT cell differentiation
biol
ogic
al_p PAX8
roce
ss
4.49
087
749
8
G
O:
sinoatrial node development
biol
ogic
4.49
087
G
O:
00
02
31
7
G
O:
00
33
51
2
TBX18
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
03
16
3
G
O:
00
16
57
6
G
O:
00
36
03
5
G
O:
00
01
79
8
G
O:
00
07
40
3
al_p
roce
ss
749
8
histone dephosphorylation
biol
ogic
al_p EYA2
roce
ss
4.49
087
749
8
osteoclast development
biol
ogic
al_p PAFAH1B1
roce
ss
4.49
087
749
8
positive regulation of type IIa
hypersensitivity
biol
ogic
al_p C3
roce
ss
4.49
087
749
8
glial cell fate determination
biol
ogic
al_p SMARCA4
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
20
00
32
5
regulation of ligand-dependent nuclear
receptor transcription coactivator activity
biol
ogic
al_p RQCD1
roce
ss
4.49
087
749
8
regulation of NK T cell proliferation
biol
ogic
al_p IL18
roce
ss
4.49
087
749
8
detection of endogenous stimulus
biol
ogic
al_p PKD2
roce
ss
4.49
087
749
8
G
O:
00
46
01
6
positive regulation of transcription by
glucose
biol
ogic
al_p USF1
roce
ss
4.49
087
749
8
G
O:
regulation of cell growth involved in cardiac
muscle cell development
biol
ogic
4.49
087
G
O:
00
51
14
0
G
O:
00
09
72
6
GSK3A
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
61
05
0
G
O:
19
00
23
8
G
O:
00
21
55
3
G
O:
00
97
03
9
G
O:
00
09
82
6
al_p
roce
ss
749
8
regulation of metanephric mesenchymal cell
migration by platelet-derived growth factor
receptor-beta signaling pathway
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
olfactory nerve development
biol
ogic
al_p NTRK1
roce
ss
4.49
087
749
8
protein linear polyubiquitination
biol
ogic
al_p SHARPIN
roce
ss
4.49
087
749
8
unidimensional cell growth
biol
ogic
al_p CADM1
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
97
11
6
gephyrin clustering
biol
ogic
al_p NLGN2
roce
ss
4.49
087
749
8
axonogenesis involved in innervation
biol
ogic
al_p NTRK1
roce
ss
4.49
087
749
8
thymine metabolic process
biol
ogic
al_p ALDH6A1
roce
ss
4.49
087
749
8
G
O:
00
32
28
9
central nervous system myelin formation
biol
ogic
al_p TENM4
roce
ss
4.49
087
749
8
G
O:
regulation of histone H2A K63-linked
ubiquitination
biol
ogic
4.49
087
G
O:
00
60
38
5
G
O:
00
19
85
9
UBR5
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
19
01
31
4
G
O:
00
38
16
5
G
O:
00
70
91
4
G
O:
00
60
15
4
G
O:
00
21
79
6
al_p
roce
ss
749
8
oncostatin-M-mediated signaling pathway
biol
ogic
al_p LIFR
roce
ss
4.49
087
749
8
UV-damage excision repair
biol
ogic
al_p INO80
roce
ss
4.49
087
749
8
cellular process regulating host cell cycle in
response to virus
biol
ogic
al_p BCL2L11
roce
ss
4.49
087
749
8
cerebral cortex regionalization
biol
ogic
al_p EMX2
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
72
06
9
DCT cell differentiation
biol
ogic
al_p PAX8
roce
ss
4.49
087
749
8
positive regulation of hh target transcription
factor activity
biol
ogic
al_p STK36
roce
ss
4.49
087
749
8
epithelial cell proliferation involved in renal
tubule morphogenesis
biol
ogic
al_p MEF2A
roce
ss
4.49
087
749
8
G
O:
00
32
24
1
positive regulation of nucleobase-containing
compound transport
biol
ogic
al_p NCBP2
roce
ss
4.49
087
749
8
G
O:
susceptibility to natural killer cell mediated
cytotoxicity
biol
ogic
4.49
087
G
O:
00
07
22
8
G
O:
20
01
01
3
CADM1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
42
27
1
G
O:
00
00
72
0
G
O:
00
34
34
4
G
O:
19
01
42
1
G
O:
00
32
06
6
al_p
roce
ss
749
8
pyrimidine dimer repair by nucleotideexcision repair
biol
ogic
al_p ERCC1
roce
ss
4.49
087
749
8
regulation of type III interferon production
biol
ogic
al_p DDX58
roce
ss
4.49
087
749
8
positive regulation of response to alcohol
biol
ogic
al_p LANCL2
roce
ss
4.49
087
749
8
nucleolus to nucleoplasm transport
biol
ogic
al_p NOC2L
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
35
02
1
negative regulation of Rac protein signal
transduction
biol
ogic
al_p NF1
roce
ss
4.49
087
749
8
regulation of beta-amyloid clearance
biol
ogic
al_p LRPAP1
roce
ss
4.49
087
749
8
negative regulation of receptor binding
biol
ogic
al_p LEF1
roce
ss
4.49
087
749
8
G
O:
00
06
42
1
asparaginyl-tRNA aminoacylation
biol
ogic
al_p NARS
roce
ss
4.49
087
749
8
G
O:
CTP salvage
biol
ogic
4.49
087
G
O:
19
00
22
1
G
O:
19
00
12
1
UCK1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
44
21
1
G
O:
00
72
03
8
al_p
roce
ss
749
8
mesenchymal stem cell maintenance
involved in nephron morphogenesis
biol
ogic
al_p PAX8
roce
ss
4.49
087
749
8
establishment or maintenance of
microtubule cytoskeleton polarity
biol
ogic
al_p LMNA
roce
ss
4.49
087
749
8
G
O:
00
43
46
1
proton-transporting ATP synthase complex
assembly
biol
ogic
al_p ATPAF2
roce
ss
4.49
087
749
8
G
O:
00
52
25
1
induction by organism of defense response
of other organism involved in symbiotic
interaction
biol
ogic
al_p SLC25A6
roce
ss
4.49
087
749
8
G
O:
00
30
95
1
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
10
69
3
negative regulation of alkaline phosphatase
activity
biol
ogic
al_p SEMA4D
roce
ss
4.49
087
749
8
exocyst localization
biol
ogic
al_p RALGAPA2
roce
ss
4.49
087
749
8
type III interferon production
biol
ogic
al_p DDX58
roce
ss
4.49
087
749
8
G
O:
00
71
42
6
ribonucleoprotein complex export from
nucleus
biol
ogic
al_p SDAD1
roce
ss
4.49
087
749
8
G
O:
prostate gland stromal morphogenesis
biol
ogic
4.49
087
G
O:
00
51
60
1
G
O:
00
34
34
3
CRIP1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
60
74
1
G
O:
00
90
06
9
G
O:
19
00
04
5
G
O:
00
44
20
8
G
O:
19
01
14
5
al_p
roce
ss
749
8
regulation of ribosome biogenesis
biol
ogic
al_p PTEN
roce
ss
4.49
087
749
8
negative regulation of protein K63-linked
ubiquitination
biol
ogic
al_p UBR5
roce
ss
4.49
087
749
8
de novo AMP biosynthetic process
biol
ogic
al_p ADSL
roce
ss
4.49
087
749
8
mesenchymal cell apoptotic process
involved in nephron morphogenesis
biol
ogic
al_p PAX8
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
90
16
1
Golgi ribbon formation
biol
ogic
al_p GCC2
roce
ss
4.49
087
749
8
regulation of type IIa hypersensitivity
biol
ogic
al_p C3
roce
ss
4.49
087
749
8
small nucleolar ribonucleoprotein complex
assembly
biol
ogic
al_p PIH1D1
roce
ss
4.49
087
749
8
G
O:
00
15
91
7
aminophospholipid transport
biol
ogic
al_p ATP11B
roce
ss
4.49
087
749
8
G
O:
regulation of inositol 1,4,5-trisphosphatesensitive calcium-release channel activity
biol
ogic
4.49
087
G
O:
00
01
79
6
G
O:
00
00
49
1
PKD2
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
31
58
5
G
O:
00
70
29
4
G
O:
00
72
27
5
G
O:
00
46
60
2
G
O:
00
55
05
9
al_p
roce
ss
749
8
renal sodium ion absorption
biol
ogic
al_p SGK1
roce
ss
4.49
087
749
8
metanephric glomerulus morphogenesis
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
regulation of mitotic centrosome separation
biol
ogic
al_p RANBP1
roce
ss
4.49
087
749
8
asymmetric neuroblast division
biol
ogic
al_p RAB10
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
20
00
72
9
positive regulation of mesenchymal cell
proliferation involved in ureter development
biol
ogic
al_p TBX18
roce
ss
4.49
087
749
8
trachea gland development
biol
ogic
al_p LEF1
roce
ss
4.49
087
749
8
detection of virus
biol
ogic
al_p DDX58
roce
ss
4.49
087
749
8
G
O:
00
32
51
3
negative regulation of protein phosphatase
type 2B activity
biol
ogic
al_p FKBP1A
roce
ss
4.49
087
749
8
G
O:
phenylpropanoid catabolic process
biol
ogic
4.49
087
G
O:
00
61
15
3
G
O:
00
09
59
7
EPHX2
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
46
27
1
G
O:
00
32
02
5
G
O:
00
90
16
9
G
O:
00
45
20
0
G
O:
00
18
24
3
al_p
roce
ss
749
8
response to cobalt ion
biol
ogic
al_p D2HGDH
roce
ss
4.49
087
749
8
regulation of spindle assembly
biol
ogic
al_p SENP6
roce
ss
4.49
087
749
8
establishment of neuroblast polarity
biol
ogic
al_p RAB10
roce
ss
4.49
087
749
8
protein O-linked glycosylation via threonine
biol
ogic
al_p GALNT2
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
15
95
9
diadenosine polyphosphate metabolic
process
biol
ogic
al_p GARS
roce
ss
4.49
087
749
8
positive regulation of myeloid leukocyte
mediated immunity
biol
ogic
al_p C3
roce
ss
4.49
087
749
8
nucleotide-excision repair, DNA incision, 5to lesion
biol
ogic
al_p ERCC1
roce
ss
4.49
087
749
8
G
O:
19
00
06
3
regulation of peroxisome organization
biol
ogic
al_p DNM1L
roce
ss
4.49
087
749
8
G
O:
regulation of thyroid hormone generation
biol
ogic
4.49
087
G
O:
00
02
88
8
G
O:
00
06
29
6
PAX8
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
20
00
60
9
G
O:
00
45
81
9
G
O:
00
03
27
3
G
O:
20
01
16
9
G
O:
00
02
44
5
al_p
roce
ss
749
8
positive regulation of glycogen catabolic
process
biol
ogic
al_p PHKG2
roce
ss
4.49
087
749
8
cell migration involved in endocardial
cushion formation
biol
ogic
al_p ENG
roce
ss
4.49
087
749
8
regulation of ATP biosynthetic process
biol
ogic
al_p FLCN
roce
ss
4.49
087
749
8
type II hypersensitivity
biol
ogic
al_p C3
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
07
22
7
signal transduction downstream of
smoothened
biol
ogic
al_p STK36
roce
ss
4.49
087
749
8
G
O:
00
02
69
3
positive regulation of cellular extravasation
biol
ogic
al_p ADAM8
roce
ss
4.49
087
749
8
G
O:
00
35
36
0
positive regulation of peroxisome
proliferator activated receptor signaling
pathway
biol
ogic
al_p PTGIS
roce
ss
4.49
087
749
8
G
O:
20
00
19
5
negative regulation of female gonad
development
biol
ogic
al_p ZFPM2
roce
ss
4.49
087
749
8
G
O:
threonyl-tRNA aminoacylation
biol
ogic
4.49
087
TARS
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
06
43
5
G
O:
00
36
26
5
G
O:
00
30
26
3
G
O:
20
00
28
6
G
O:
00
51
28
0
al_p
roce
ss
749
8
RNA (guanine-N7)-methylation
biol
ogic
al_p WDR4
roce
ss
4.49
087
749
8
apoptotic chromosome condensation
biol
ogic
al_p ACIN1
roce
ss
4.49
087
749
8
receptor internalization involved in
canonical Wnt receptor signaling pathway
biol
ogic
al_p RAB5A
roce
ss
4.49
087
749
8
negative regulation of release of
sequestered calcium ion into cytosol
biol
ogic
al_p FKBP1A
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
61
36
4
apoptotic process involved in luteolysis
biol
ogic
al_p ROBO2
roce
ss
4.49
087
749
8
lateral mesodermal cell differentiation
biol
ogic
al_p FGFR1
roce
ss
4.49
087
749
8
nucleotide-excision repair, DNA incision, 3to lesion
biol
ogic
al_p ERCC1
roce
ss
4.49
087
749
8
G
O:
00
72
03
9
regulation of mesenchymal cell apoptotic
process involved in nephron morphogenesis
biol
ogic
al_p PAX8
roce
ss
4.49
087
749
8
G
O:
regulation of type II hypersensitivity
biol
ogic
4.49
087
G
O:
00
48
37
1
G
O:
00
06
29
5
C3
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
02
89
2
G
O:
00
61
15
2
G
O:
00
32
28
6
G
O:
00
51
14
2
G
O:
00
01
30
6
al_p
roce
ss
749
8
trachea submucosa development
biol
ogic
al_p LEF1
roce
ss
4.49
087
749
8
central nervous system myelin maintenance
biol
ogic
al_p PTEN
roce
ss
4.49
087
749
8
positive regulation of NK T cell proliferation
biol
ogic
al_p IL18
roce
ss
4.49
087
749
8
age-dependent response to oxidative stress
biol
ogic
al_p CLN8
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
60
16
6
olfactory pit development
biol
ogic
al_p ALDH1A3
roce
ss
4.49
087
749
8
farnesyl diphosphate metabolic process
biol
ogic
al_p FDPS
roce
ss
4.49
087
749
8
ribosome localization
biol
ogic
al_p SDAD1
roce
ss
4.49
087
749
8
G
O:
00
71
93
0
negative regulation of transcription involved
in G1/S phase of mitotic cell cycle
biol
ogic
al_p RB1
roce
ss
4.49
087
749
8
G
O:
protein O-linked glycosylation via serine
biol
ogic
4.49
087
G
O:
00
45
33
8
G
O:
00
33
75
0
GALNT2
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
18
24
2
G
O:
00
35
56
2
G
O:
20
00
98
4
G
O:
00
71
40
4
G
O:
00
21
81
4
al_p
roce
ss
749
8
negative regulation of chromatin binding
biol
ogic
al_p SENP2
roce
ss
4.49
087
749
8
negative regulation of ATP citrate synthase
activity
biol
ogic
al_p PHPT1
roce
ss
4.49
087
749
8
cellular response to low-density lipoprotein
particle stimulus
biol
ogic
al_p NPC1
roce
ss
4.49
087
749
8
cell motility involved in cerebral cortex radial
glia guided migration
biol
ogic
al_p SRGAP2
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
20
00
46
6
negative regulation of glycogen (starch)
synthase activity
biol
ogic
al_p GSK3A
roce
ss
4.49
087
749
8
negative regulation of T-helper 2 cell
differentiation
biol
ogic
al_p BCL6
roce
ss
4.49
087
749
8
negative regulation of nucleoside metabolic
process
biol
ogic
al_p FLCN
roce
ss
4.49
087
749
8
G
O:
00
72
38
5
minus-end-directed organelle transport
along microtubule
biol
ogic
al_p BICD1
roce
ss
4.49
087
749
8
G
O:
attachment of spindle microtubules to
kinetochore involved in mitotic sister
biol
ogic
4.49
087
G
O:
00
45
62
9
G
O:
00
45
97
8
RB1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
51
31
5
G
O:
00
70
16
3
G
O:
00
72
27
6
G
O:
00
07
57
1
G
O:
00
60
17
9
chromatid segregation
al_p
roce
ss
749
8
regulation of adiponectin secretion
biol
ogic
al_p C1QTNF3
roce
ss
4.49
087
749
8
metanephric glomerulus vasculature
morphogenesis
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
age-dependent general metabolic decline
biol
ogic
al_p CLN8
roce
ss
4.49
087
749
8
male mating behavior
biol
ogic
al_p PTEN
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
20
00
78
5
regulation of autophagic vacuole assembly
biol
ogic
al_p TBC1D14
roce
ss
4.49
087
749
8
G
O:
00
07
52
9
establishment of synaptic specificity at
neuromuscular junction
biol
ogic
al_p GPHN
roce
ss
4.49
087
749
8
G
O:
00
15
01
4
heparan sulfate proteoglycan biosynthetic
process, polysaccharide chain biosynthetic
process
biol
ogic
al_p EXT1
roce
ss
4.49
087
749
8
G
O:
00
34
62
5
fatty acid elongation, monounsaturated fatty
acid
biol
ogic
al_p ELOVL1
roce
ss
4.49
087
749
8
G
O:
oxidative DNA demethylation
biol
ogic
4.49
087
ALKBH3
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
35
51
1
G
O:
19
00
18
1
G
O:
00
00
43
2
G
O:
00
48
29
5
G
O:
00
45
19
6
al_p
roce
ss
749
8
negative regulation of protein localization to
nucleus
biol
ogic
al_p FLCN
roce
ss
4.49
087
749
8
positive regulation of transcription from RNA
polymerase II promoter by glucose
biol
ogic
al_p USF1
roce
ss
4.49
087
749
8
positive regulation of isotype switching to
IgE isotypes
biol
ogic
al_p STAT6
roce
ss
4.49
087
749
8
establishment or maintenance of neuroblast
polarity
biol
ogic
al_p RAB10
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
50
86
1
positive regulation of B cell receptor
signaling pathway
biol
ogic
al_p PRKCH
roce
ss
4.49
087
749
8
arginyl-tRNA aminoacylation
biol
ogic
al_p RARS
roce
ss
4.49
087
749
8
rRNA-containing ribonucleoprotein complex
export from nucleus
biol
ogic
al_p SDAD1
roce
ss
4.49
087
749
8
G
O:
00
45
82
9
negative regulation of isotype switching
biol
ogic
al_p BCL6
roce
ss
4.49
087
749
8
G
O:
negative regulation of mesenchymal cell
apoptotic process involved in nephron
biol
ogic
4.49
087
G
O:
00
06
42
0
G
O:
00
71
42
8
PAX8
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
72
04
0
G
O:
20
00
59
1
G
O:
00
19
05
5
G
O:
00
33
18
3
G
O:
19
01
31
5
morphogenesis
al_p
roce
ss
749
8
positive regulation of metanephric
mesenchymal cell migration
biol
ogic
al_p PDGFRB
roce
ss
4.49
087
749
8
modification by virus of host cell cycle
regulation
biol
ogic
al_p BCL2L11
roce
ss
4.49
087
749
8
negative regulation of histone ubiquitination
biol
ogic
al_p UBR5
roce
ss
4.49
087
749
8
negative regulation of histone H2A K63linked ubiquitination
biol
ogic
al_p UBR5
roce
ss
4.49
087
749
8
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
G
O:
00
32
51
2
regulation of protein phosphatase type 2B
activity
biol
ogic
al_p FKBP1A
roce
ss
4.49
087
749
8
negative regulation of isotype switching to
IgE isotypes
biol
ogic
al_p BCL6
roce
ss
4.49
087
749
8
negative regulation of hydrogen peroxide
metabolic process
biol
ogic
al_p HDAC6
roce
ss
4.49
087
749
8
G
O:
00
51
34
0
regulation of ligase activity
biol
ogic
PSMB10,SMAD7,PSMB9,ANAPC4,PLK1,PTEN,PSMC6,PSMC4,CDC14
al_p
B,PSMA1
roce
ss
1.34
726
324
9
G
O:
Rho guanyl-nucleotide exchange factor
activity
mol
ecul
1.40
330
G
O:
00
48
29
4
G
O:
00
10
72
7
MCF2L,ARHGEF12,ARHGEF25,PLEKHG4,PLEKHG5,RASGRF2,ARHG
EF7,FARP1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
7
E
0
1
2.
0
00
05
08
9
G
O:
00
51
18
8
G
O:
00
00
81
9
G
O:
00
50
86
7
G
O:
00
71
56
5
ar_f
unct
ion
003
6
cofactor biosynthetic process
biol
ogic
PTS,HSD17B12,PNPO,PDXK,SLC11A2,GCDH,NADSYN1,NADK,FECH,
al_p
ELOVL1,FPGS,GPHN,PANK3
roce
ss
1.28
782
516
5
sister chromatid segregation
biol
ogic
al_p INO80,NIPBL,RB1,CHMP1A,NCAPD3,MAU2
roce
ss
1.49
695
916
6
positive regulation of cell activation
biol
ogic SART1,HLA-DPB1,DPP4,BCL6,IL15RA,HLAal_p DQA1,ADAM8,PTPN6,IL18,FYN,MEF2A,CSK,PTPRC,PAK1,NCK2,CD27
roce 6,GLI3,LGALS8,TNFRSF14,IGF2,STAT6,PDPK1
ss
1.20
486
957
3
nBAF complex
cell
ular
_co SMARCD3,SMARCA4
mpo
nent
2.33
222
129
6
9
E
0
1
2.
0
9
E
0
1
2.
1
0
E
0
1
2.
1
0
E
0
1
2.
1
0
E
0
1
G
O:
00
00
78
2
telomere cap complex
cell
ular
_co OBFC1,ACD
mpo
nent
2.33
222
129
6
exon-exon junction complex
cell
ular
_co UPF3A,UPF1
mpo
nent
2.33
222
129
6
dendrite cytoplasm
cell
ular
_co UHMK1,CANX
mpo
nent
2.33
222
129
6
G
O:
00
34
51
8
RNA cap binding complex
cell
ular
_co FMR1,NCBP2
mpo
nent
2.33
222
129
6
G
O:
trans-Golgi network transport vesicle
membrane
cell
ular
2.33
222
G
O:
00
35
14
5
G
O:
00
32
83
9
CLTCL1,CLTB
2.
1
0
E
0
1
2.
1
0
E
0
1
2.
1
0
E
0
1
2.
1
0
E
0
1
2.
1
00
12
51
0
G
O:
00
36
03
8
G
O:
00
00
78
3
G
O:
00
80
13
4
G
O:
00
70
49
1
_co
mpo
nent
129
6
TCTN-B9D complex
cell
ular
_co TCTN1,CC2D2A
mpo
nent
2.33
222
129
6
nuclear telomere cap complex
cell
ular
_co OBFC1,ACD
mpo
nent
2.33
222
129
6
regulation of response to stress
biol
ogic
al_p
roce
ss
CADM1,IGF1R,NLRP1,SUPT5H,BCL6,PTPN22,XBP1,ADAM8,MINK1,P
TPN6,IGBP1,NOD1,STAT2,NPC1,BCLAF1,TBC1D14,WAC,C2,CFB,TAB
2,SHARPIN,RNF8,MDM2,CREB1,DDX58,RPS6KA5,MAPK8IP3,RNF168
,PAFAH1B1,IL18,NR1H3,FAP,FYN,FBXW7,IKBKB,LTBR,NCOR1,MEF2
A,FECH,SETD8,MAPK8,MYLK,TRIM28,MAP4K4,CDK6,PAK1,C3,C1QT
NF3,CD276,NRBP2,SLC25A6,MDFI,PTGIS,PDCD4,PSMA1,NSMCE4A,
SPRED1,DUSP6,PDPK1,USF1,STK24,UBR5
1.10
930
041
8
repressing transcription factor binding
mol
ecul
ar_f
unct
ion
NOC2L,CBX5,TBP,RUNX2,RUNX1
1.57
055
382
0
E
0
1
2.
1
0
E
0
1
2.
1
0
E
0
1
2.
1
0
E
0
1
2.
1
0
E
0
1
G
O:
00
07
62
8
adult walking behavior
biol
ogic
al_p NPC1,CLN8,HEXA,CTNS
roce
ss
1.68
407
906
2
negative regulation of fat cell differentiation
biol
ogic
al_p ZFPM2,TGFB1I1,NCOR2,GATA2
roce
ss
1.68
407
906
2
positive regulation of reactive oxygen
species metabolic process
biol
ogic
al_p ZC3H12A,IL18,NOX4,PDGFRB
roce
ss
1.68
407
906
2
G
O:
00
51
05
8
negative regulation of small GTPase
mediated signal transduction
biol
ogic
al_p BCL6,NF1,FLCN,DGKZ
roce
ss
1.68
407
906
2
G
O:
apoptotic nuclear changes
biol
ogic
1.68
407
G
O:
00
45
59
9
G
O:
20
00
37
9
SHARPIN,KPNB1,ACIN1,KPNA1
2.
1
1
E
0
1
2.
1
1
E
0
1
2.
1
1
E
0
1
2.
1
1
E
0
1
2.
1
00
30
26
2
G
O:
00
03
33
8
G
O:
00
06
34
2
G
O:
20
00
75
6
G
O:
00
07
41
6
al_p
roce
ss
906
2
metanephros morphogenesis
biol
ogic
al_p PAX8,PKD2,PDGFRB,PKD1
roce
ss
1.68
407
906
2
chromatin silencing
biol
ogic
al_p SIRT2,SMARCA4,BAZ2A,RRP8
roce
ss
1.68
407
906
2
regulation of peptidyl-lysine acetylation
biol
ogic
al_p NOC2L,RPS6KA5,FLCN,GATA2
roce
ss
1.68
407
906
2
synapse assembly
biol
ogic
al_p CADM1,BDNF,PDLIM5,PTEN,PTPRD,FARP1,NLGN2,ROBO2
roce
ss
1.39
975
402
5
1
E
0
1
2.
1
1
E
0
1
2.
1
1
E
0
1
2.
1
1
E
0
1
2.
1
1
E
0
1
G
O:
19
01
36
2
organic cyclic compound biosynthetic
process
FZD6,PBX2,KANK2,GTF3C2,RAI1,IGF1R,PTS,SIRT2,MYNN,NOC2L,RA
F1,ZNF131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20H,
PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,CUX1,EED,SMAD7,
MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,
EMX2,RBPMS,ZSCAN31,XBP1,FDPS,PAM,HSD17B12,APITD1,USP47,
ADAM8,POLR3E,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,NO
D1,STAT2,PLK1,ZNF446,PNPO,PTGES2,ZNF621,HDGF,FDXR,PPP5C,
CCNL1,CHD6,ZC3H12A,SLC11A2,FAM58A,TBX18,LBX2,PCGF1,DR1,B
CLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,WAC,ZNF142,FUBP3,ZNF54
0,ALDH18A1,FGFR1,HSF4,GTF3C1,NADSYN1,ADCY4,PAF1,TAB2,SG
K1,DPF2,NADK,IDI1,MDM2,PRKCH,PPM1F,ZNF595,TBP,YY1,INO80,G
MEB2,PFDN5,CREB1,FLII,RPRD1A,DDX58,RPL27,CCNL2,PTPRK,NF1,
ZEB1,IFITM3,ASCC2,RGMB,EBF1,RPL9,MED28,NPR1,ZNF3,RPS6KA5
biol ,NIPBL,ADSL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,MZ
ogic F1,ZFPM2,TP53BP1,ZNF865,SENP2,STARD3,SUB1,CHMP1A,PDE8A,
al_p ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GARS,USP7,FLCN,ZN
roce F605,ZNF410,GMDS,RPL24,RPL37A,SAP30BP,VPS72,PTEN,RNASEK,
ss
RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,PPP1
R10,MEF2A,FECH,SETD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX
3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,IMPDH1,UBP1,WD
R61,EBF4,ZNF148,ZNF76,SP110,NCK2,TCF4,IKZF5,HMGN2,SEMA4D,
SSBP2,ERC1,NFYC,HSD17B4,SRSF10,SS18,RCOR3,SMAD4,CHURC1
,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF44,CREBZF,
ING4,ZNF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,ATP5A1,GLI3,MAP
K12,CCDC59,DCAF6,AK5,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,Z
NF692,PHF1,STK36,WWP1,PHF12,MED6,MDFI,ZNF554,HINFP,NCBP2
,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,SMARCA4,N
AA16,LRPPRC,RPLP0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3
,GSK3A,SNRPE,ZNF383,POLR2J3,NCOR2,FPGS,SETD2,IGF2,PTGIS,
TROVE2,ATXN3,PHF21A,GPHN,PDCD4,SOX13,CHD2,STAT6,ZNF138,
1.04
086
339
6
2.
1
1
E
0
1
ZNF705A,NTRK1,TFAM,BRWD1,SMAD9,TGFBR3,ZBTB16,BAZ2A,UCK
1,RRP8,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,CDK5RAP
3,PANK3,EYA2,SMARCAD1,CC2D1A,GATA2,PABPN1
G
O:
00
12
50
2
G
O:
00
05
77
0
G
O:
00
07
03
0
G
O:
00
07
09
8
induction of programmed cell death
biol
ogic NLRP1,PPP1R13B,CASP4,LEF1,BCL2L13,BCL2L11,NOD1,SHISA5,BC
al_p LAF1,STK4,DPF2,TNFRSF25,DFNA5,CASP2,SAP30BP,PTEN,DIABLO,
roce STK24
ss
1.23
100
195
4
late endosome
cell
ular
PLD1,HGS,DERL2,NPC1,SLC11A2,VAMP7,HLA_co
DMB,IFITM3,STARD3,LGMN,CTNS,MCOLN1,TSG101,CD63
mpo
nent
1.27
212
070
7
Golgi organization
biol
ogic
al_p COG4,SYNE1,GCC2,DYM,TMED2
roce
ss
1.56
658
517
4
centrosome cycle
biol
ogic
al_p CEP135,RANBP1,PKD2,PLK2,CDK5RAP2
roce
ss
1.56
658
517
4
2.
1
1
E
0
1
2.
1
1
E
0
1
2.
1
2
E
0
1
2.
1
2
E
0
1
G
O:
00
32
97
0
regulation of actin filament-based process
biol
ogic
al_p
roce
ss
negative regulation of cell adhesion
biol
ogic
al_p LAMB1,BCL6,LEF1,JAM2,NF1,PTEN,PTPRC,TBCD,CD164
roce
ss
1.36
240
103
9
G
O:
00
07
36
8
determination of left/right symmetry
biol
ogic
al_p NPHP3,TBX2,DISP1,PKD2,IFT172,MEF2A,TMED2,ENG,C2CD3
roce
ss
1.36
240
103
9
G
O:
00
16
81
1
mol
ecul
hydrolase activity, acting on carbon-nitrogen
ar_f
(but not peptide) bonds, in linear amides
unct
ion
G
O:
00
44
cellular nitrogen compound biosynthetic
process
G
O:
00
07
16
2
biol
ogic
al_p
roce
ARPC4TTLL3,PAM,CAPZB,ACTR3,PPM1F,SSH2,ARPC2,PHPT1,MEF2A,WAS
H4P,VILL,PAK1,NCK2,CSF1R,ACTR2,FHOD1,NOX4,PDGFRB,TWF1,S
SH1
1.21
375
067
5
SIRT2,HDAC6,GLS,NCOR1,MAPK8,SIRT7,SIRT3
1.43
253
545
4
FZD6,PBX2,KANK2,EIF2B4,GTF3C2,RAI1,PTS,SIRT2,MYNN,NOC2L,R
AF1,ZNF131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20
H,PWP1,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,CUX1,EED,SMAD
7,MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF8
1.04
035
772
2
2.
1
4
E
0
1
2.
1
4
E
0
1
2.
1
4
E
0
1
2.
1
5
E
0
1
2.
1
5
E
27
1
G
O:
ss
glycerolipid metabolic process
biol
ogic
3,EMX2,RBPMS,ZSCAN31,XBP1,PAM,APITD1,USP47,ADAM8,POLR3E
,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,STAT2,PLK1,
ZNF446,PNPO,ASNS,PTGES2,ZNF621,HDGF,PPP5C,CCNL1,CHD6,ZC
3H12A,SLC11A2,FAM58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,Z
NF397,JHDM1D,ZNF710,WAC,ZNF142,FUBP3,ZNF540,FGFR1,HSF4,G
TF3C1,NADSYN1,ADCY4,PAF1,TAB2,SGK1,DPF2,NADK,MDM2,PRKC
H,PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,FLII,RPRD1
A,DDX58,RPL27,CCNL2,PTPRK,NF1,ZEB1,IFITM3,ASCC2,RGMB,EBF
1,RPL9,MED28,NPR1,ZNF3,RPS6KA5,NIPBL,ADSL,BRD9,ZNF837,PKD
2,RXRB,LMNA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,ZNF865,SEN
P2,SUB1,CHMP1A,PDE8A,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR
1H3,GARS,USP7,FLCN,ZNF605,ZNF410,GMDS,RPL24,RPL37A,SAP30
BP,VPS72,PTEN,RNASEK,RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,R
QCD1,RFX7,NCOR1,PPP1R10,MEF2A,FECH,SETD8,PIAS2,MAPK8,M
YCBP2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CD
K5RAP2,OAZ1,IMPDH1,UBP1,WDR61,EBF4,ZNF148,ZNF76,SP110,NC
K2,TCF4,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,NFYC,SRSF10,SS18,R
COR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,DDAH1,INO80E,DTYMK,RPL4,MTRR,Z
NF44,CREBZF,ING4,ZNF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,ATP
5A1,GLI3,MAPK12,CCDC59,DCAF6,AK5,ENG,SIRT7,ZSCAN5A,TCF12,
ARNT,NOX4,ZNF692,PHF1,STK36,WWP1,PHF12,MED6,MDFI,ZNF554,
HINFP,NCBP2,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX
1,SMARCA4,NAA16,LRPPRC,RPLP0,RAD54L2,ZNF518B,CRCP,ZNF90
,ZNF638,PER3,GSK3A,SNRPE,ZNF383,POLR2J3,NCOR2,FPGS,SETD
2,IGF2,PTGIS,TROVE2,ATXN3,PHF21A,PDCD4,SOX13,CHD2,STAT6,Z
NF138,ZNF705A,NTRK1,TFAM,BRWD1,SMAD9,HBB,TGFBR3,ZBTB16,
BAZ2A,UCK1,RRP8,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC
1,DDAH2,CDK5RAP3,PANK3,EYA2,SMARCAD1,CC2D1A,GATA2,PAB
PN1
TAZ,PLD1,GPAA1,PGS1,SMPD4,HSD17B12,PRKACA,PIGS,PIGG,PIG
N,CHKB,GPAT2,PAFAH1B1,GPCPD1,NR1H3,PLD6,MTMR14,PTEN,FB
0
1
1.16
478
2.
1
00
46
48
6
G
O:
00
21
54
3
al_p XW7,CSF1R,C3,ELOVL1,MBOAT2,LPCAT1,PDGFRB,PCYT1A,PIGO,L
roce MF1,ALG9,PLA2G16
ss
090
7
pallium development
biol
ogic
LEF1,EMX2,NF1,PAFAH1B1,PTEN,SRGAP2,MEF2A,PTPRS,CDK6,GLI
al_p
3
roce
ss
1.33
392
400
9
water-soluble vitamin metabolic process
biol
ogic
al_p PNPO,PDXK,NADSYN1,NADK,SLC23A2,FPGS,GPHN
roce
ss
1.42
891
556
7
G
O:
19
01
60
7
alpha-amino acid biosynthetic process
biol
ogic
al_p EIF2B4,SHMT2,GLS,ASNS,ALDH18A1,MTRR,THNSL2
roce
ss
1.42
891
556
7
G
O:
00
43
15
4
negative regulation of cysteine-type
endopeptidase activity involved in apoptotic
process
biol
ogic
al_p RAF1,LEF1,USP47,CSNK2A1,IGBP1,MDM2,HERPUD1
roce
ss
1.42
891
556
7
G
O:
00
06
76
7
6
E
0
1
2.
1
6
E
0
1
2.
1
7
E
0
1
2.
1
7
E
0
1
2.
1
7
E
0
1
G
O:
00
33
07
7
T cell differentiation in thymus
biol
ogic
al_p ADAM8,MINK1,JAG2,ZEB1,PTPRC,CDK6,GLI3
roce
ss
1.42
891
556
7
leukocyte proliferation
biol
ogic
CADM1,PSMB10,BTN3A1,BCL6,PTPN22,LEF1,PTPN6,RC3H1,IL18,FY
al_p
N,MEF2A,PTPRC,IMPDH1,NCK2,CD276,TNFRSF14,IGF2,CD151
roce
ss
1.22
478
477
2
oxidoreductase activity, acting on the CHCH group of donors
mol
ecul
ar_f
unct
ion
ACADVL,GCDH,ACAA1,PTGR2,SDHA,PTGR1
1.47
346
503
8
G
O:
00
01
10
5
RNA polymerase II transcription coactivator
activity
mol
ecul
ar_f
unct
ion
ZFPM2,MEF2A,SMARCA4
1.84
183
129
8
G
O:
ion channel inhibitor activity
mol
ecul
RSC1A1,FKBP1A,PHPT1
1.84
183
G
O:
00
70
66
1
G
O:
00
16
62
7
2.
1
7
E
0
1
2.
1
7
E
0
1
2.
2
0
E
0
1
2.
2
0
E
0
1
2.
2
00
08
20
0
G
O:
00
16
24
8
G
O:
00
31
97
0
G
O:
00
14
06
5
G
O:
00
51
43
9
ar_f
unct
ion
129
8
channel inhibitor activity
mol
ecul
ar_f
unct
ion
organelle envelope lumen
cell
ular
_co SHMT2,NLN,TIMM23,DTYMK,GOLPH3,DIABLO
mpo
nent
1.47
298
187
1
phosphatidylinositol 3-kinase cascade
biol
ogic
al_p IGF1R,PTPN6,FGFR1,NF1,PTEN,NCOR1,SEMA4D,PDGFRB
roce
ss
1.38
180
846
1
regulation of ubiquitin-protein ligase activity
involved in mitotic cell cycle
biol
ogic
al_p PSMB10,PSMB9,ANAPC4,PLK1,PTEN,PSMC6,PSMC4,PSMA1
roce
ss
1.38
180
846
1
RSC1A1,FKBP1A,PHPT1
1.84
183
129
8
0
E
0
1
2.
2
0
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
G
O:
00
70
37
3
negative regulation of ERK1 and ERK2
cascade
biol
ogic
al_p FLCN,CSK,DUSP6
roce
ss
1.83
717
715
8
response to gonadotropin stimulus
biol
ogic
al_p PAX8,ASNS,TGFBR3
roce
ss
1.83
717
715
8
mesodermal cell fate commitment
biol
ogic
al_p FGFR1,FOXC1,EYA2
roce
ss
1.83
717
715
8
G
O:
00
60
29
1
long-term synaptic potentiation
biol
ogic
al_p NPTN,PLK2,PTEN
roce
ss
1.83
717
715
8
G
O:
detection of mechanical stimulus involved in
sensory perception
biol
ogic
1.83
717
G
O:
00
34
69
8
G
O:
00
01
71
0
IL18,FYN,NTRK1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
00
50
97
4
G
O:
00
72
20
7
G
O:
00
60
76
5
G
O:
00
60
35
1
G
O:
00
02
68
4
al_p
roce
ss
715
8
metanephric epithelium development
biol
ogic
al_p PAX8,PKD2,PKD1
roce
ss
1.83
717
715
8
regulation of androgen receptor signaling
pathway
biol
ogic
al_p HDAC6,PIAS2,SMARCA4
roce
ss
1.83
717
715
8
cartilage development involved in
endochondral bone morphogenesis
biol
ogic
al_p COL9A1,COL2A1,THBS3
roce
ss
1.83
717
715
8
positive regulation of immune system
process
biol
ogic
al_p
roce
ss
1.12
271
937
4
CADM1,BTN3A1,SART1,HLA-DPB1,DPP4,BCL6,PTPN22,IL15RA,HLADQA1,ADAM8,PTPN6,VASP,NOD1,RC3H1,C2,CFB,TAB2,PRKCH,CRE
B1,DDX58,LCP2,RPS6KA5,IL18,NR1H3,PTEN,FYN,C1R,PHPT1,IKBKB,
MEF2A,MAPK8,CSK,PTPRC,RARRES2,PAK1,NCK2,C3,CD276,C1S,GL
I3,LGALS8,TNFRSF14,IGF2,STAT6,CACNB3,DUSP6,PDPK1
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
G
O:
00
43
27
4
phospholipase binding
G
O:
00
16
81
3
mol
ecul
hydrolase activity, acting on carbon-nitrogen
ar_f
(but not peptide) bonds, in linear amidines
unct
ion
G
O:
00
34
73
9
histone deacetylase activity (H4-K16
specific)
mol
ecul
ar_f
unct
ion
G
O:
00
97
37
2
G
O:
mol
ecul
ar_f
unct
ion
PAFAH1B1,LMNB1
2.25
112
714
2
DDAH1,DDAH2
2.25
112
714
2
HDAC6,SIRT7
2.25
112
714
2
NAD-dependent histone deacetylase
activity (H3-K18 specific)
mol
ecul
ar_f
unct
ion
HDAC6,SIRT7
2.25
112
714
2
ferrous iron binding
mol
ecul
ALKBH3,FECH
2.25
112
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
1
E
0
1
2.
2
00
08
19
8
G
O:
00
45
29
5
G
O:
00
71
33
3
G
O:
00
55
00
8
G
O:
00
50
68
4
ar_f
unct
ion
714
2
gamma-catenin binding
mol
ecul
ar_f
unct
ion
cellular response to glucose stimulus
biol
ogic
al_p PRKACA,AACS,PHPT1,MEF2A,OXCT1,NOX4
roce
ss
1.46
974
172
7
cardiac muscle tissue morphogenesis
biol
ogic
al_p SMAD7,FKBP1A,ZFPM2,GAA,TGFBR3,FOXC1
roce
ss
1.46
974
172
7
regulation of mRNA processing
biol
ogic
al_p SFSWAP,PAF1,SRPK1,SRSF10,CDK11A,PABPC1
roce
ss
1.46
974
172
7
LEF1,PTPRK
2.25
112
714
2
1
E
0
1
2.
2
1
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
G
O:
00
71
33
1
cellular response to hexose stimulus
biol
ogic
al_p PRKACA,AACS,PHPT1,MEF2A,OXCT1,NOX4
roce
ss
1.46
974
172
7
cellular respiration
biol
ogic
BDNF,TAZ,IDH3G,ADSL,IDH1,COX7A2L,DLST,ATP5A1,NDUFV1,NDUF
al_p
S2,ETFA,SDHA,IDH3B,SIRT3,UQCRH
roce
ss
1.24
746
597
2
iron-sulfur cluster assembly
biol
ogic
al_p MMS19,NUBP1
roce
ss
2.24
543
874
9
G
O:
00
14
00
2
astrocyte development
biol
ogic
al_p NF1,CDK6
roce
ss
2.24
543
874
9
G
O:
positive regulation of protein deacetylation
biol
ogic
2.24
543
G
O:
00
45
33
3
G
O:
00
16
22
6
NIPBL,NCOR1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
00
90
31
2
G
O:
00
48
70
3
G
O:
00
31
16
3
G
O:
00
48
93
5
G
O:
00
32
61
6
al_p
roce
ss
874
9
embryonic viscerocranium morphogenesis
biol
ogic
al_p NIPBL,MEF2A
roce
ss
2.24
543
874
9
metallo-sulfur cluster assembly
biol
ogic
al_p MMS19,NUBP1
roce
ss
2.24
543
874
9
peripheral nervous system neuron
development
biol
ogic
al_p TBCE,RUNX1
roce
ss
2.24
543
874
9
interleukin-13 production
biol
ogic
al_p LEF1,IL18
roce
ss
2.24
543
874
9
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
G
O:
00
60
39
0
regulation of SMAD protein import into
nucleus
biol
ogic
al_p RBPMS,SMAD4
roce
ss
2.24
543
874
9
thymocyte apoptotic process
biol
ogic
al_p ADAM8,GLI3
roce
ss
2.24
543
874
9
white fat cell differentiation
biol
ogic
al_p AACS,NCOR2
roce
ss
2.24
543
874
9
G
O:
20
00
05
0
regulation of non-canonical Wnt receptor
signaling pathway
biol
ogic
al_p NPHP3,ANKRD6
roce
ss
2.24
543
874
9
G
O:
respiratory chain complex IV assembly
biol
ogic
2.24
543
G
O:
00
70
24
2
G
O:
00
50
87
2
COX14,BCS1L
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
00
08
53
5
G
O:
00
45
83
0
G
O:
00
72
17
6
G
O:
00
46
62
9
G
O:
00
48
02
5
al_p
roce
ss
874
9
positive regulation of isotype switching
biol
ogic
al_p PTPRC,STAT6
roce
ss
2.24
543
874
9
nephric duct development
biol
ogic
al_p PKD2,PKD1
roce
ss
2.24
543
874
9
gamma-delta T cell activation
biol
ogic
al_p JAG2,PTPRC
roce
ss
2.24
543
874
9
negative regulation of mRNA splicing, via
spliceosome
biol
ogic
al_p SFSWAP,SRSF10
roce
ss
2.24
543
874
9
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
G
O:
00
40
01
5
negative regulation of multicellular organism
growth
biol
ogic
al_p RAI1,LGMN
roce
ss
2.24
543
874
9
outflow tract septum morphogenesis
biol
ogic
al_p TBX2,ZFPM2
roce
ss
2.24
543
874
9
regulation of cardiac muscle cell
differentiation
biol
ogic
al_p MEF2A,GSK3A
roce
ss
2.24
543
874
9
G
O:
00
03
41
7
growth plate cartilage development
biol
ogic
al_p COL9A1,THBS3
roce
ss
2.24
543
874
9
G
O:
protein localization to synapse
biol
ogic
2.24
543
G
O:
00
03
14
8
G
O:
20
00
72
5
CEP112,NLGN2
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
00
35
41
8
G
O:
00
03
21
4
G
O:
00
07
25
2
G
O:
00
08
63
1
G
O:
00
31
44
2
al_p
roce
ss
874
9
cardiac left ventricle morphogenesis
biol
ogic
al_p CPE,GSK3A
roce
ss
2.24
543
874
9
I-kappaB phosphorylation
biol
ogic
al_p IKBKB,ERC1
roce
ss
2.24
543
874
9
intrinsic apoptotic signaling pathway in
response to oxidative stress
biol
ogic
al_p DIABLO,STK24
roce
ss
2.24
543
874
9
positive regulation of mRNA 3-end
processing
biol
ogic
al_p PAF1,PABPC1
roce
ss
2.24
543
874
9
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
G
O:
00
48
93
4
peripheral nervous system neuron
differentiation
biol
ogic
al_p TBCE,RUNX1
roce
ss
2.24
543
874
9
positive regulation of humoral immune
response
biol
ogic
al_p PTPRC,C3
roce
ss
2.24
543
874
9
bone maturation
biol
ogic
al_p THBS3,SEMA4D
roce
ss
2.24
543
874
9
G
O:
00
21
51
4
ventral spinal cord interneuron
differentiation
biol
ogic
al_p GLI3,GATA2
roce
ss
2.24
543
874
9
G
O:
Ras guanyl-nucleotide exchange factor
activity
mol
ecul
1.30
328
G
O:
00
02
92
2
G
O:
00
70
97
7
MCF2L,ARHGEF12,ARHGEF25,PLEKHG4,PLEKHG5,DENND4C,RASG
RF2,ARHGEF7,FARP1,RGL2,DENND6B
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
2
E
0
1
2.
2
00
05
08
8
G
O:
00
05
78
2
G
O:
00
55
03
8
G
O:
00
31
90
7
G
O:
20
00
14
7
ar_f
unct
ion
413
5
peroxisomal matrix
cell
ular
_co ACAA1,IDH1,HSD17B4,LONP2
mpo
nent
1.64
627
385
6
recycling endosome membrane
cell
ular
_co ATP11B,WASH4P,RAB10,SCAMP1
mpo
nent
1.64
627
385
6
microbody lumen
cell
ular
_co ACAA1,IDH1,HSD17B4,LONP2
mpo
nent
1.64
627
385
6
positive regulation of cell motility
biol
ogic IGF1R,LAMB1,HDAC6,LEF1,ADAM8,AAMP,PPM1F,COL18A1,NRP1,PH
al_p PT1,MYLK,PTPRC,RARRES2,SEMA6A,CTSH,SEMA4D,CSF1R,SUN2,
roce NOX4,PDGFRB,ELP6
ss
1.19
883
594
2
3
E
0
1
2.
2
3
E
0
1
2.
2
3
E
0
1
2.
2
3
E
0
1
2.
2
3
E
0
1
G
O:
00
46
63
1
alpha-beta T cell activation
biol
ogic
al_p BCL6,LEF1,RC3H1,IL18,NCOR1,PTPRC,GLI3,TNFRSF14,STAT6
roce
ss
1.34
726
324
9
female gonad development
biol
ogic
EIF2B4,ADAMTS1,CASP2,ZFPM2,IDH1,COL9A3,RUNX1,ROBO2,FOXC
al_p
1
roce
ss
1.34
726
324
9
antigen processing and presentation of
exogenous peptide antigen via MHC class II
biol
ogic
HLA-DPB1,DYNC1I1,HLA-DQA1,HLAal_p
DMB,SEC31A,LGMN,KLC1,CANX,DYNC1I2
roce
ss
1.34
726
324
9
G
O:
00
30
30
7
positive regulation of cell growth
biol
ogic
DERL2,LEF1,USP47,CSNK2A1,INO80,NOL8,PAFAH1B1,N6AMT1,SEM
al_p
A4D
roce
ss
1.34
726
324
9
G
O:
histone methyltransferase activity
mol
ecul
1.53
485
G
O:
00
08
58
5
G
O:
00
19
88
6
EED,EHMT1,PRMT5,SETD8,SETD2
2.
2
3
E
0
1
2.
2
3
E
0
1
2.
2
3
E
0
1
2.
2
3
E
0
1
2.
2
00
42
05
4
G
O:
00
08
37
4
G
O:
00
09
88
7
G
O:
00
01
19
0
G
O:
00
04
17
ar_f
unct
ion
941
5
O-acyltransferase activity
mol
ecul
ar_f
unct
ion
organ morphogenesis
FZD6,IGF1R,LAMB1,NPHP3,COL9A1,BDNF,CPE,COL2A1,TBX2,CNTF,
SMAD7,GLG1,LEF1,PAX8,ADAMTS1,BCL2L11,PAM,LHX4,JAG2,TBX18
biol
,FGFR1,FKBP1A,YY1,THBS3,NF1,ZEB1,CRIP1,COL18A1,NIPBL,PKD2,
ogic
MAPK8IP3,ZFPM2,PAFAH1B1,ADAM15,NRP1,STX2,PTEN,ALDH1A3,R
al_p
UNX2,FBXW7,SMARCD3,MEF2A,MYLK,EVC,SEMA6A,CTSH,SMAD4,G
roce
LI3,TMED2,ENG,GAA,MDFI,PDGFRB,COL8A1,RUNX1,SMARCA4,GSK
ss
3A,ANKRD6,NCOR2,FPGS,SETD2,COL13A1,TGFBR3,PKD1,FOXC1,A
CAN,C2CD3,GATA2
RNA polymerase II transcription factor
binding transcription factor activity involved
in positive regulation of transcription
mol
ecul
ar_f
unct
ion
aminopeptidase activity
mol
ecul
ar_f
unct
ion
TAZ,CPT1B,GPAT2,MBOAT2,LPCAT1
1.53
485
941
5
1.09
717
246
7
CREB1,ZFPM2,MEF2A,SMARCA4
1.63
718
337
6
DPP4,DNPEP,CTSH,DPP7
1.63
718
337
6
4
E
0
1
2.
2
4
E
0
1
2.
2
4
E
0
1
2.
2
5
E
0
1
2.
2
5
E
-
7
G
O:
00
15
48
5
cholesterol binding
mol
ecul
ar_f
unct
ion
tRNA binding
mol
ecul
ar_f
unct
ion
regulation of cellular component size
biol
ogic ARPC4al_p TTLL3,CAPZB,ACTR3,CLN8,SSH2,CREB1,PAFAH1B1,ARPC2,NRP1,P
roce TEN,WASH4P,VILL,NCK2,SEMA4D,ACTR2,TWF1,SSH1
ss
1.22
478
477
2
G
O:
00
48
04
1
focal adhesion assembly
biol
ogic
al_p PPM1F,PTPRK,PTEN,PXN,PDPK1
roce
ss
1.53
098
096
5
G
O:
CD4-positive, alpha-beta T cell
differentiation
biol
ogic
1.53
098
G
O:
00
00
04
9
G
O:
00
32
53
5
NPC1,STARD3,NR1H3,OSBPL3
1.63
718
337
6
RARS,SLFN11,FARSA,PSTK
1.63
718
337
6
BCL6,LEF1,RC3H1,NCOR1,STAT6
0
1
2.
2
5
E
0
1
2.
2
5
E
0
1
2.
2
6
E
0
1
2.
2
6
E
0
1
2.
2
00
43
36
7
G
O:
00
15
29
7
G
O:
00
09
10
1
G
O:
00
30
90
1
G
O:
00
09
45
2
al_p
roce
ss
096
5
antiporter activity
mol
ecul
ar_f
unct
ion
SLC9B2,SLC26A6,SLC4A2,SLC9A5,SLC4A4,SLC25A6,SLC9A8
1.41
115
432
8
glycoprotein biosynthetic process
biol
ogic
al_p
roce
ss
SIRT2,ST3GAL1,XYLT1,NPC1,SEC31A,MCFD2,ALG6,ST3GAL4,GCNT
2,EDEM2,GALNT2,UST,NECAB3,MAN1A2,ST6GALNAC5,FUT4,MGAT5
,B4GALT4,EXT1,B3GAT3,MAN2A2,MAN1B1,CANX,PDIA3,LMF1,SIRT3,
ACAN,ALG9
1.16
430
157
4
midbrain development
biol
ogic
al_p FZD6,JHDM1D,FGFR1,SMAD9
roce
ss
1.63
304
636
3
7-methylguanosine RNA capping
biol
ogic
al_p SUPT5H,WDR4,NCBP2,TGS1
roce
ss
1.63
304
636
3
6
E
0
1
2.
2
6
E
0
1
2.
2
6
E
0
1
2.
2
7
E
0
1
2.
2
7
E
0
1
G
O:
00
10
81
2
negative regulation of cell-substrate
adhesion
biol
ogic
al_p BCL6,NF1,PTEN,TBCD
roce
ss
1.63
304
636
3
regulation of synapse assembly
biol
ogic
al_p BDNF,PDLIM5,NLGN2,ROBO2
roce
ss
1.63
304
636
3
regulation of pathway-restricted SMAD
protein phosphorylation
biol
ogic
al_p SMAD7,RBPMS,SMAD4,ENG
roce
ss
1.63
304
636
3
G
O:
00
02
29
4
CD4-positive, alpha-beta T cell
differentiation involved in immune response
biol
ogic
al_p BCL6,LEF1,RC3H1,STAT6
roce
ss
1.63
304
636
3
G
O:
RNA capping
biol
ogic
1.63
304
G
O:
00
51
96
3
G
O:
00
60
39
3
SUPT5H,WDR4,NCBP2,TGS1
2.
2
7
E
0
1
2.
2
7
E
0
1
2.
2
7
E
0
1
2.
2
7
E
0
1
2.
2
00
36
26
0
G
O:
00
42
09
3
G
O:
00
14
00
3
al_p
roce
ss
636
3
T-helper cell differentiation
biol
ogic
al_p BCL6,LEF1,RC3H1,STAT6
roce
ss
1.63
304
636
3
oligodendrocyte development
biol
ogic
al_p EIF2B4,CD9,PTEN,TENM4
roce
ss
1.63
304
636
3
USP10,CRBN,PSMB10,RAF1,NLRP1,DDI2,CPE,DPP4,NLN,USP4,CAS
P4,LEF1,PSMB9,ADAMTS1,BCL2L13,BCL2L11,CPM,SCRN3,USP47,A
DAM8,CSNK2A1,IGBP1,NOD1,PREPL,SLC11A2,ATG4B,DNPEP,USP2
0,C2,CFB,MMP16,MDM2,RHBDD1,PPM1F,RHBDF1,SERPINH1,CAPN1
0,CASP2,USP24,USP3,SENP2,MTCH1,TPP1,CHMP1A,ADAM15,USP33
,USP7,FAP,C1R,LGMN,HERPUD1,ADAMTS18,USP15,AGBL5,CTSH,C3
,C1S,PCSK7,DIABLO,USP40,RHBDF2,LONRF3,ATG4A,PDIA3,ATXN3,
DPP7,LONP2,PSMA1,TNFRSF10B,STAMBPL1,CPAMD8,SPCS3,SENP
6,MMP25
G
O:
00
08
23
3
peptidase activity
mol
ecul
ar_f
unct
ion
G
O:
00
30
negative regulation of transforming growth
factor beta receptor signaling pathway
biol
ogic
SMAD7,GLG1,USP15,TGFB1I1,ENG,TGFBR3,PDPK1
al_p
roce
7
E
0
1
2.
2
7
E
0
1
2.
2
7
E
0
1
1.09
115
769
7
2.
2
7
E
0
1
1.40
758
846
9
2.
2
8
E
51
2
G
O:
00
72
40
4
G
O:
00
50
77
3
G
O:
00
72
41
3
G
O:
00
45
59
8
ss
signal transduction involved in G1/S
transition checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.40
758
846
9
regulation of dendrite development
biol
ogic
al_p SIPA1L1,PDLIM5,ACTR3,CAPRIN1,PTEN,SEMA4D,PTPRD
roce
ss
1.40
758
846
9
signal transduction involved in mitotic cell
cycle checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.40
758
846
9
regulation of fat cell differentiation
biol
ogic
al_p ZC3H12A,CREB1,ZFPM2,TGFB1I1,NCOR2,ZBTB16,GATA2
roce
ss
1.40
758
846
9
0
1
2.
2
8
E
0
1
2.
2
8
E
0
1
2.
2
8
E
0
1
2.
2
8
E
0
1
G
O:
00
72
43
1
signal transduction involved in mitotic cell
cycle G1/S transition DNA damage
checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.40
758
846
9
G
O:
00
42
99
0
regulation of transcription factor import into
nucleus
biol
ogic
al_p DDX58,NF1,PKD2,C1QTNF3,FLNA,MDFI,PKD1
roce
ss
1.40
758
846
9
G
O:
00
06
97
7
DNA damage response, signal transduction
by p53 class mediator resulting in cell cycle
arrest
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.40
758
846
9
signal transduction involved in mitotic cell
cycle G1/S checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.40
758
846
9
regulation of neuron projection development
biol
SIPA1L1,PDLIM5,ACTR3,FGFR1,CAPRIN1,SSH2,NPTN,PAFAH1B1,NR
ogic
P1,PTEN,FYN,SEMA4D,PTPRD,KIF13B,ROBO2,PMP22,NTRK1,STK24,
al_p
SSH1
roce
1.20
745
291
2
G
O:
00
72
47
4
G
O:
00
10
2.
2
8
E
0
1
2.
2
8
E
0
1
2.
2
8
E
0
1
2.
2
8
E
0
1
2.
2
8
E
97
5
G
O:
00
44
09
2
G
O:
00
05
92
9
G
O:
00
08
16
8
G
O:
00
30
21
7
ss
0
1
negative regulation of molecular function
FZD6,PSMB10,IGF1R,MYO1D,RAF1,SMAD7,HDAC6,RNH1,LEF1,PSM
B9,USP47,PTPN6,CSNK2A1,IGBP1,ANAPC4,PLK1,ZC3H12A,CLN8,TN
biol
K2,MDM2,FKBP1A,PPM1F,ZCCHC9,SERPINH1,NF1,RTKN,PKD2,RB1,
ogic
SENP2,SYTL2,ANXA5,SH3BP5,BICD1,RGS3,USP7,PTEN,IQGAP1,PHP
al_p
T1,HERPUD1,PPP1R10,PRKRIP1,MAPK8,CSK,PTPRC,OAZ1,PSMC6,P
roce
SMC4,LEPR,SEMA4D,DGKZ,C3,LRPAP1,FLNA,TMED2,ENG,MDFI,RG
ss
S2,FARP1,GSK3A,PTGIS,PDCD4,CRIPAK,PSMA1,CDK5RAP1,SPRED
1,DUSP6,CPAMD8,PDPK1,WNK1
cilium
cell
ular NPHP3,GAS8,TTLL3,BBS1,PTPRK,PKD2,PAFAH1B1,IFT172,TCTN1,R
_co AB8A,CLTB,WDR35,EVC,RAB10,GLI3,DZIP1,CC2D2A,PTPN23,TTLL11
mpo ,TMEM237,SEPT2,PKD1
nent
1.18
862
243
6
methyltransferase activity
mol
ecul
ar_f
unct
ion
SHMT2,EED,AMT,EHMT1,PRMT10,METTL3,PRMT5,NTMT1,SETD8,N6
AMT1,WDR4,TGS1,THUMPD2,SETD2,FTSJ3,RRP8,HEMK1
1.22
135
621
5
T cell differentiation
biol
ogic
SART1,BCL6,PTPN22,LEF1,ADAM8,MINK1,JAG2,RC3H1,ZEB1,RUNX2
al_p
,NCOR1,PTPRC,CDK6,GLI3,STAT6
roce
ss
1.23
981
280
6
1.09
494
893
1
2.
2
8
E
0
1
2.
2
9
E
0
1
2.
2
9
E
0
1
2.
2
9
E
0
1
G
O:
00
07
51
7
G
O:
00
09
45
1
G
O:
00
60
07
0
G
O:
00
07
59
6
G
O:
00
43
muscle organ development
biol
ogic SIRT2,UTRN,BDNF,TAZ,SIN3B,LUC7L,TBX2,CNTF,SMAD7,LEF1,FGF
al_p R1,DISP1,FKBP1A,NF1,LMNA,ZFPM2,MEF2A,MYLK,PAK1,EVC,MAPK
roce 12,TCF12,GAA,CD164,GSK3A,ITGA11,GPHN,TANC1,TGFBR3,FOXC1
ss
1.15
479
707
1
RNA modification
biol
ogic
al_p METTL3,PARN,WDR4,RPUSD4,TGS1,FTSJ3,CDK5RAP1,MTO1
roce
ss
1.36
431
721
5
canonical Wnt receptor signaling pathway
biol
ogic
FZD6,CDK14,NPHP3,LEF1,TBX18,STK4,PFDN5,G3BP1,PTEN,RNF146,
al_p
RAB5A,GLI3,BICC1,GSK3A,ANKRD6,CSNK1E,UBR5
roce
ss
1.21
826
996
blood coagulation
biol
ogic
al_p
roce
ss
1.12
495
142
1
pigmentation
biol
ogic
LEF1,BCL2L11,HPS4,NF1,MITF,BLOC1S5,MEF2A,HPS3,GLI3
al_p
roce
FZD6,PPIL2,RAF1,GP1BB,F11R,SLC16A3,ATP2B1,CBX5,DGKA,CAPZ
B,CD9,PTPN6,PRKACA,SLC16A1,JAM2,HPS4,PRKCH,LCP2,ITGA3,GN
AI1,ZFPM2,ESAM,ANXA5,FAP,FYN,CSK,VPS45,DGKZ,KLC1,FLNA,RA
B5A,ITGA5,RAD51B,RAP1B,TLN1,DOCK8,PHF21A,HBB,PDPK1,USF1,
CD63,GATA2
1.33
245
815
9
2.
3
0
E
0
1
2.
3
1
E
0
1
2.
3
2
E
0
1
2.
3
2
E
0
1
2.
3
3
E
47
3
G
O:
00
34
14
2
G
O:
00
35
26
4
G
O:
00
30
33
6
G
O:
00
15
08
5
ss
toll-like receptor 4 signaling pathway
biol
ogic
al_p NOD1,TAB2,CREB1,RPS6KA5,NR1H3,IKBKB,MEF2A,MAPK8,DUSP6
roce
ss
1.33
245
815
9
multicellular organism growth
biol
ogic
RAI1,GIGYF2,CELF1,PDE4D,CREB1,NIPBL,TENC1,LGMN,NCOR1,TM
al_p
ED2,ERCC1,CLIC4
roce
ss
1.27
300
464
5
negative regulation of cell migration
biol
ogic
SMAD7,NISCH,KRIT1,PTPRK,NF1,FLCN,PTEN,SRGAP2,ENG,CLIC4,T
al_p
GFBR3,STK24
roce
ss
1.27
300
464
5
calcium ion transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
1.23
537
465
1
ATP2B1,SLC11A2,CAMK2D,TPCN2,SGK1,FKBP1A,PKD2,PHPT1,CAC
NB1,TMEM66,TRPM7,CACNB3,CACNA2D1,CACNA2D4,PKD1
0
1
2.
3
3
E
0
1
2.
3
3
E
0
1
2.
3
3
E
0
1
2.
3
3
E
0
1
G
O:
00
44
74
4
protein targeting to nucleus
biol
ogic
BCL6,NUP98,RBPMS,KPNA6,DDX58,NF1,PKD2,LMNA,KPNB1,PPP1R1
al_p
0,SMAD4,C1QTNF3,FLNA,GLI3,MDFI,PDIA3,PKD1,KPNA1,UBR5
roce
ss
1.20
178
411
9
protein import into nucleus
biol
ogic
BCL6,NUP98,RBPMS,KPNA6,DDX58,NF1,PKD2,LMNA,KPNB1,PPP1R1
al_p
0,SMAD4,C1QTNF3,FLNA,GLI3,MDFI,PDIA3,PKD1,KPNA1,UBR5
roce
ss
1.20
178
411
9
regulation of generation of precursor
metabolites and energy
biol
ogic
al_p GRB10,NCOR1,PHKG2,ARNT,GSK3A,IGF2
roce
ss
1.44
349
633
9
G
O:
00
71
32
6
cellular response to monosaccharide
stimulus
biol
ogic
al_p PRKACA,AACS,PHPT1,MEF2A,OXCT1,NOX4
roce
ss
1.44
349
633
9
G
O:
00
02
humoral immune response mediated by
circulating immunoglobulin
biol
ogic
PTPN6,C2,C1R,PTPRC,C3,C1S
al_p
roce
1.44
349
633
9
G
O:
00
06
60
6
G
O:
00
43
46
7
2.
3
4
E
0
1
2.
3
4
E
0
1
2.
3
4
E
0
1
2.
3
4
E
0
1
2.
3
4
E
45
5
G
O:
00
18
21
0
G
O:
00
06
49
7
G
O:
00
51
22
2
G
O:
00
43
28
1
ss
peptidyl-threonine modification
biol
ogic
al_p SMAD7,PLK1,GALNT2,MAPK8,SPRED1,PDPK1
roce
ss
1.44
349
633
9
protein lipidation
biol
ogic
al_p GPAA1,PIGS,PIGG,PIGN,PIGO,ALG9
roce
ss
1.44
349
633
9
positive regulation of protein transport
biol
ogic
CADM1,NLRP1,SYTL4,RBPMS,ADAM8,PRKACA,DNM1L,MDM2,DDX58
al_p
,CSF1R,SMAD4,C1QTNF3,FLNA,GLI3,KPNA1,UBR5
roce
ss
1.22
478
477
2
regulation of cysteine-type endopeptidase
activity involved in apoptotic process
biol
ogic
RAF1,NLRP1,LEF1,BCL2L13,BCL2L11,USP47,CSNK2A1,IGBP1,NOD1,
al_p
SLC11A2,MDM2,PPM1F,MTCH1,HERPUD1,DIABLO,TNFRSF10B
roce
ss
1.22
478
477
2
0
1
2.
3
4
E
0
1
2.
3
4
E
0
1
2.
3
4
E
0
1
2.
3
4
E
0
1
G
O:
00
51
18
6
G
O:
00
34
65
4
cofactor metabolic process
biol
ogic PTS,SHMT2,H6PD,HSD17B12,PNPO,FDXR,PDXK,SLC11A2,GCDH,NA
al_p DSYN1,NADK,FMO2,IDH1,FECH,HSD17B4,ELOVL1,DLST,IDH3B,FPG
roce S,GPHN,PANK3
ss
nucleobase-containing compound
biosynthetic process
FZD6,PBX2,KANK2,GTF3C2,RAI1,SIRT2,MYNN,NOC2L,RAF1,ZNF131,
RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20H,PWP1,BCL
6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,CUX1,EED,SMAD7,MCF2L,HD
AC6,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,EMX2,RBP
MS,ZSCAN31,XBP1,PAM,APITD1,USP47,ADAM8,POLR3E,GABPB1,PC
GF6,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,STAT2,PLK1,ZNF446,PTG
ES2,ZNF621,HDGF,PPP5C,CCNL1,CHD6,ZC3H12A,FAM58A,TBX18,LB
X2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,WAC,ZNF1
42,FUBP3,ZNF540,FGFR1,HSF4,GTF3C1,NADSYN1,ADCY4,PAF1,TAB
2,SGK1,DPF2,NADK,MDM2,PRKCH,PPM1F,ZNF595,TBP,YY1,INO80,G
biol MEB2,PFDN5,CREB1,FLII,RPRD1A,DDX58,RPL27,CCNL2,PTPRK,NF1,
ogic ZEB1,IFITM3,ASCC2,RGMB,EBF1,RPL9,MED28,NPR1,ZNF3,RPS6KA5
al_p ,NIPBL,ADSL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRMT5,MZ
roce F1,ZFPM2,TP53BP1,ZNF865,SENP2,SUB1,CHMP1A,PDE8A,ZNF558,Z
ss
NF263,ZNF180,BICD1,ZNF276,NR1H3,GARS,USP7,FLCN,ZNF605,ZNF
410,GMDS,RPL24,RPL37A,SAP30BP,VPS72,PTEN,RNASEK,RUNX2,C
STF1,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,PPP1R10,MEF2
A,SETD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41,PBX3,ZNF565,ABCA2
,AFF4,TRIM28,DMTF1,CDK5RAP2,IMPDH1,UBP1,WDR61,EBF4,ZNF14
8,ZNF76,SP110,NCK2,TCF4,IKZF5,HMGN2,SEMA4D,SSBP2,ERC1,NF
YC,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF44,CREBZF,
ING4,ZNF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,ATP5A1,GLI3,MAP
K12,CCDC59,DCAF6,AK5,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,Z
NF692,PHF1,STK36,WWP1,PHF12,MED6,MDFI,ZNF554,HINFP,NCBP2
1.18
876
169
1
2.
3
5
E
0
1
1.03
801
983
9
2.
3
5
E
0
1
,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,SMARCA4,N
AA16,LRPPRC,RPLP0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3
,GSK3A,SNRPE,ZNF383,POLR2J3,NCOR2,SETD2,IGF2,PTGIS,TROVE
2,ATXN3,PHF21A,PDCD4,SOX13,CHD2,STAT6,ZNF138,ZNF705A,NTR
K1,TFAM,BRWD1,SMAD9,TGFBR3,ZBTB16,BAZ2A,UCK1,RRP8,PHF1
9,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,CDK5RAP3,PANK3,EYA
2,SMARCAD1,CC2D1A,GATA2,PABPN1
G
O:
00
02
00
9
G
O:
00
05
86
8
G
O:
00
42
57
5
G
O:
00
45
morphogenesis of an epithelium
biol
ogic
al_p
roce
ss
cytoplasmic dynein complex
cell
ular
_co DYNC1I1,DYNC1I2
mpo
nent
2.15
281
965
7
DNA polymerase complex
cell
ular
_co CRCP,POLG
mpo
nent
2.15
281
965
7
regulation of cell differentiation
biol
ogic
al_p
roce
1.08
035
260
6
FZD6,IGF1R,NPHP3,TBX2,LEF1,PAX8,VASP,JAG2,TBX18,STK4,FGFR
1,PKD2,NRP1,ALDH1A3,IFT172,PXN,MEF2A,TCTN1,TRIM28,PAK1,RA
B10,CTSH,CSF1R,SMAD4,TGFB1I1,GLI3,TMED2,ENG,ITGA5,ANKRD6
,SETD2,CLIC4,PKD1,C2CD3
NPHP3,RAF1,BDNF,SART1,BCL6,CNTF,SMAD7,GLG1,IL15RA,LEF1,P
AX8,ADAM8,SIPA1L1,PDLIM5,PTPN6,ACTR3,PRKACA,RC3H1,ZC3H1
2A,FGFR1,HSF4,CAPRIN1,PAF1,PRKCH,SSH2,CREB1,NPTN,NF1,ZEB
1,MED28,NIPBL,MITF,RB1,LTBP4,ZFPM2,BLOC1S5,PAFAH1B1,ARPC
1.13
947
638
2.
3
6
E
0
1
2.
3
7
E
0
1
2.
3
7
E
0
1
2.
3
8
E
59
5
G
O:
00
51
08
7
G
O:
00
08
13
8
G
O:
00
45
17
8
G
O:
00
05
97
ss
2,NR1H3,FLCN,NRP1,VPS72,PTEN,FYN,RUNX2,SMARCD3,SRGAP2,
MEF2A,CDK5RAP2,PTPRC,CDK6,WDR61,STAG2,SEMA6A,TCF4,SEM
A4D,SMAD4,TGFB1I1,CD276,GLI3,MAPK12,TCF12,ARNT,MED6,PTPR
D,RUNX1,SMARCA4,KIF13B,GSK3A,NCOR2,ACIN1,ROBO2,PMP22,C
DK5RAP1,BNIP2,NTRK1,SMAD9,DUSP6,TGFBR3,ZBTB16,STK24,SSH
1,CDK5RAP3,TENM4,GATA2
0
1
chaperone binding
mol
ecul
ar_f
unct
ion
protein tyrosine/serine/threonine
phosphatase activity
mol
ecul
ar_f
unct
ion
basal part of cell
cell
ular
_co ITGA9,SLC11A2,PKD2,SLC23A2
mpo
nent
1.59
923
746
glycogen metabolic process
biol
ogic
al_p GRB10,PHKG2,GAA,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.38
688
863
9
DNAJC10,CP,TBCD,GRPEL2,TBCE
1.50
075
142
8
SSH2,PTEN,CDC14B,DUSP6,SSH1
1.50
075
142
8
2.
3
8
E
0
1
2.
3
8
E
0
1
2.
3
8
E
0
1
2.
3
9
E
-
7
G
O:
00
43
40
7
negative regulation of MAP kinase activity
biol
ogic
al_p PTPN6,NF1,RGS3,RGS2,PDCD4,SPRED1,DUSP6
roce
ss
1.38
688
863
9
signal transduction involved in DNA integrity
checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.38
688
863
9
transcription factor import into nucleus
biol
ogic
al_p DDX58,NF1,PKD2,C1QTNF3,FLNA,MDFI,PKD1
roce
ss
1.38
688
863
9
G
O:
00
72
42
2
signal transduction involved in DNA
damage checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.38
688
863
9
G
O:
mitotic cell cycle checkpoint
biol
ogic
1.25
103
G
O:
00
72
40
1
G
O:
00
42
99
1
PSMB10,PSMB9,CSNK2A1,ANAPC4,MDM2,CASP2,RB1,PLK2,CHFR,P
SMC6,PSMC4,DGKZ,PSMA1
0
1
2.
3
9
E
0
1
2.
3
9
E
0
1
2.
3
9
E
0
1
2.
3
9
E
0
1
2.
4
00
07
09
3
G
O:
19
01
88
0
G
O:
00
04
70
4
G
O:
00
19
20
0
G
O:
00
15
29
9
al_p
roce
ss
016
negative regulation of protein
depolymerization
biol
ogic
al_p HDAC6,CAPZB,VILL,TWF1,CLASP1
roce
ss
1.49
695
916
6
NF-kappaB-inducing kinase activity
mol
ecul
ar_f
unct
ion
ZFP91,CARD14,TNFRSF10B
1.76
175
167
6
carbohydrate kinase activity
mol
ecul
ar_f
unct
ion
GALK2,NAGK,RBKS
1.76
175
167
6
solute:hydrogen antiporter activity
mol
ecul
ar_f
unct
ion
SLC9B2,SLC9A5,SLC9A8
1.76
175
167
6
0
E
0
1
2.
4
0
E
0
1
2.
4
0
E
0
1
2.
4
0
E
0
1
2.
4
0
E
0
1
G
O:
00
51
96
0
regulation of nervous system development
biol
ogic
al_p
roce
ss
MyD88-dependent toll-like receptor
signaling pathway
biol
ogic
al_p NOD1,TAB2,CREB1,RPS6KA5,IKBKB,MEF2A,MAPK8,DUSP6
roce
ss
1.34
726
324
9
negative regulation of cellular carbohydrate
metabolic process
biol
ogic
al_p GRB10,C1QTNF3,GSK3A
roce
ss
1.75
729
989
G
O:
00
34
60
5
cellular response to heat
biol
ogic
al_p XYLT1,DHX9,ATXN3
roce
ss
1.75
729
989
G
O:
regulation of natural killer cell activation
biol
ogic
1.75
729
G
O:
00
02
75
5
G
O:
00
10
67
7
NPHP3,BDNF,CNTF,SIPA1L1,PDLIM5,ACTR3,FGFR1,CAPRIN1,PRKC
H,SSH2,NPTN,NF1,ZEB1,PAFAH1B1,NRP1,PTEN,FYN,SMARCD3,SR
GAP2,MEF2A,CDK5RAP2,SEMA6A,TCF4,SEMA4D,GLI3,TCF12,PTPR
D,KIF13B,NLGN2,ROBO2,PMP22,CDK5RAP1,BNIP2,NTRK1,STK24,SS
H1,CDK5RAP3,TENM4
PTPN22,IL15RA,IL18
1.12
766
527
5
2.
4
1
E
0
1
2.
4
1
E
0
1
2.
4
1
E
0
1
2.
4
1
E
0
1
2.
4
00
32
81
4
G
O:
00
01
91
3
G
O:
00
01
78
2
G
O:
00
45
58
1
G
O:
00
46
63
3
al_p
roce
ss
989
T cell mediated cytotoxicity
biol
ogic
al_p CADM1,PTPRC,CTSH
roce
ss
1.75
729
989
B cell homeostasis
biol
ogic
al_p BCL2L11,IKBKB,MEF2A
roce
ss
1.75
729
989
negative regulation of T cell differentiation
biol
ogic
al_p BCL6,RC3H1,GLI3
roce
ss
1.75
729
989
alpha-beta T cell proliferation
biol
ogic
al_p IL18,PTPRC,TNFRSF14
roce
ss
1.75
729
989
1
E
0
1
2.
4
1
E
0
1
2.
4
1
E
0
1
2.
4
1
E
0
1
2.
4
1
E
0
1
G
O:
00
01
10
2
1.58
903
092
3
2.
4
2
E
0
1
1.09
378
330
8
2.
4
3
E
0
1
RNA polymerase II activating transcription
factor binding
mol
ecul
ar_f
unct
ion
cell activation
FZD6,CADM1,PSMB10,BTN3A1,RAF1,GP1BB,SART1,HLADPB1,DPP4,BCL6,PTPN22,IL15RA,DGKA,LEF1,HLAbiol
DQA1,ADAM8,CD9,MINK1,PTPN6,IGBP1,JAG2,RC3H1,ZC3H12A,POL
ogic
M,VAMP7,RNF8,FKBP1A,PRKCH,LCP2,ZEB1,ZNF3,PRMT5,GNAI1,RN
al_p
F168,IL18,NR1H3,FYN,RUNX2,NCOR1,MEF2A,CSK,PTPRC,SWAP70,I
roce
MPDH1,CDK6,PAK1,NCK2,DGKZ,CD276,FLNA,GLI3,ERCC1,LGALS8,T
ss
NFRSF14,RAP1B,KIF13B,TLN1,IGF2,STAT6,NTRK1,CD151,PDPK1,CD
63
ureteric bud development
biol
ogic
BDNF,SMAD7,PAX8,FGFR1,PKD2,SMAD4,GLI3,ROBO2,SMAD9,FOXC
al_p
1
roce
ss
1.29
544
543
2
G
O:
00
71
90
1
negative regulation of protein
serine/threonine kinase activity
biol
ogic
PTPN6,PLK1,NF1,RGS3,PTEN,RGS2,PDCD4,CDK5RAP1,SPRED1,DU
al_p
SP6
roce
ss
1.29
544
543
2
G
aromatic compound biosynthetic process
biol
1.03
G
O:
00
01
77
5
G
O:
00
01
65
7
CREB1,RB1,TP53BP1,NCOR1
FZD6,PBX2,KANK2,GTF3C2,RAI1,PTS,SIRT2,MYNN,NOC2L,RAF1,ZN
2.
4
3
E
0
1
2.
4
3
E
0
1
2.
O:
00
19
43
8
ogic
al_p
roce
ss
F131,RSC1A1,SFSWAP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20H,PWP1
,BCL6,FUBP1,ZNF783,CMPK2,TBX2,MMS19,CUX1,EED,SMAD7,MCF2
L,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,PAX8,SUPT4H1,ZNF83,EMX2
,RBPMS,ZSCAN31,XBP1,PAM,APITD1,USP47,ADAM8,POLR3E,GABP
B1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,STAT2,PLK1,ZNF44
6,PTGES2,ZNF621,HDGF,PPP5C,CCNL1,CHD6,ZC3H12A,SLC11A2,FA
M58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZN
F710,WAC,ZNF142,FUBP3,ZNF540,FGFR1,HSF4,GTF3C1,NADSYN1,A
DCY4,PAF1,TAB2,SGK1,DPF2,NADK,MDM2,PRKCH,PPM1F,ZNF595,T
BP,YY1,INO80,GMEB2,PFDN5,CREB1,FLII,RPRD1A,DDX58,RPL27,CC
NL2,PTPRK,NF1,ZEB1,IFITM3,ASCC2,RGMB,EBF1,RPL9,MED28,NPR
1,ZNF3,RPS6KA5,NIPBL,ADSL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF
,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,ZNF865,SENP2,SUB1,CHMP1A,P
DE8A,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,GARS,USP7,FL
CN,ZNF605,ZNF410,GMDS,RPL24,RPL37A,SAP30BP,VPS72,PTEN,RN
ASEK,RUNX2,CSTF1,FBXW7,SMARCD3,IKBKB,RQCD1,RFX7,NCOR1,
PPP1R10,MEF2A,FECH,SETD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41
,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,IMPDH1,UBP
1,WDR61,EBF4,ZNF148,ZNF76,SP110,NCK2,TCF4,IKZF5,HMGN2,SEM
A4D,SSBP2,ERC1,NFYC,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHU
RC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,DTYMK,RPL4,ZNF44,CREBZF,
ING4,ZNF687,NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,ATP5A1,GLI3,MAP
K12,CCDC59,DCAF6,AK5,ENG,SIRT7,ZSCAN5A,TCF12,ARNT,NOX4,Z
NF692,PHF1,STK36,WWP1,PHF12,MED6,MDFI,ZNF554,HINFP,NCBP2
,MLX,PDGFRB,TGS1,CDK11A,GLIS3,ELP6,BDP1,RUNX1,SMARCA4,N
AA16,LRPPRC,RPLP0,RAD54L2,ZNF518B,CRCP,ZNF90,ZNF638,PER3
,GSK3A,SNRPE,ZNF383,POLR2J3,NCOR2,FPGS,SETD2,IGF2,PTGIS,
TROVE2,ATXN3,PHF21A,PDCD4,SOX13,CHD2,STAT6,ZNF138,ZNF70
5A,NTRK1,TFAM,BRWD1,SMAD9,TGFBR3,ZBTB16,BAZ2A,UCK1,RRP
8,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,CDK5RAP3,PAN
K3,EYA2,SMARCAD1,CC2D1A,GATA2,PABPN1
635
634
6
4
3
E
0
1
G
O:
19
01
88
8
G
O:
00
06
22
1
G
O:
00
90
13
0
G
O:
00
01
56
9
G
O:
00
34
regulation of cell junction assembly
biol
ogic
al_p PRKACA,PRKCH,PPM1F,PTEN
roce
ss
1.58
501
558
7
pyrimidine nucleotide biosynthetic process
biol
ogic
al_p CMPK2,DTYMK,AK5,UCK1
roce
ss
1.58
501
558
7
tissue migration
biol
ogic
al_p HDAC6,PPM1F,CTSH,TGFBR3
roce
ss
1.58
501
558
7
patterning of blood vessels
biol
ogic
al_p LEF1,STK4,NRP1,ENG
roce
ss
1.58
501
558
7
microtubule anchoring
biol
ogic
RB1,BICD1,GCC2,CLASP1
al_p
roce
1.58
501
558
7
2.
4
3
E
0
1
2.
4
3
E
0
1
2.
4
3
E
0
1
2.
4
3
E
0
1
2.
4
3
E
45
3
G
O:
00
30
14
0
G
O:
00
06
06
6
G
O:
00
08
13
4
G
O:
19
01
69
9
ss
trans-Golgi network transport vesicle
cell
ular
_co CLTCL1,CLTB,GOPC
mpo
nent
1.74
916
597
2
alcohol metabolic process
biol
ogic ACADVL,GK5,EPHX2,SMPD4,FDPS,FDXR,NPC1,CLN8,CHKB,IDI1,CY
al_p P2R1,PAFAH1B1,ISYNA1,GPCPD1,STARD3,PTEN,LGMN,SNX17,FEC
roce H,LEPR,ALDH3B1,MBOAT2,LPCAT1,EBPL,PCYT1A,LMF1,PLA2G16
ss
1.15
479
707
1
transcription factor binding
mol
ecul
ar_f
unct
ion
PBX2,SIRT2,NOC2L,CBX5,LEF1,DHX9,HDGF,DIP2A,DR1,STK4,TBP,C
REB1,ZEB1,RB1,ZFPM2,TP53BP1,USP7,RUNX2,SMARCD3,NCOR1,M
EF2A,EBF4,UBA2,TCF4,FLNA,EPN1,ARNT,STK36,PHF12,MED6,MDFI,
MLX,RUNX1,SMARCA4,NCOR2,USF1,FOXC1,GATA2
1.12
556
357
1
cellular response to nitrogen compound
biol
ogic
al_p
roce
ss
IGF1R,RAF1,EEF2K,ATP6V1D,PTPN6,PRKACA,COL16A1,FGFR1,ADC
Y4,MDM2,ZEB1,EIF4B,RAB31,CAPN10,IL18,GRB10,FYN,PXN,MEF2A,
DENND4C,CSK,PAK1,LEPROT,RAB10,RHEB,GNB3,ATP6V0A1,NOX4,
GSK3A,IGF2,NTRK1,PDPK1,USF1,SSH1
1.13
383
540
8
0
1
2.
4
4
E
0
1
2.
4
4
E
0
1
2.
4
4
E
0
1
2.
4
5
E
0
1
multi-organism reproductive process
PSMB10,LAMB1,F11R,CDK13,CBX5,SUPT5H,VAPB,NUP98,VRK2,LEF
1,HLAbiol
C,SUPT4H1,PSMB9,BCL2L11,FDPS,PAM,RAD23A,STAT2,COL16A1,T
ogic
RO,MDM2,TBP,CREB1,DDX58,RPL27,IFITM3,RPL9,RXRB,RB1,BICD1,
al_p
USP7,CUL4A,RPL24,RPL37A,PTEN,FYN,SRPK1,FBXW7,KPNB1,LTBR,
roce
UBP1,SP110,KLC1,RPL4,TMED2,EPN1,THOC2,SLC25A6,WWP1,ITGA
ss
5,NCBP2,EPOR,TNFRSF14,SMARCA4,RPLP0,DYNC1I2,TSG101,USF1
,KPNA1,PABPN1
guanyl ribonucleotide binding
mol
ecul
ar_f
unct
ion
EIF2B4,SEPT5,RAB34,GBP3,MCF2L,ARHGEF12,LANCL2,ARHGEF25,
RGL4,RAB35,RANBP1,RHOF,EEF1A1,DNM1L,RHOBTB1,HERC2,SEPT
4,EFTUD2,RAB24,MTG1,RAB18,PLEKHG4,RALGPS2,PLEKHG5,RTKN,
NPR1,RAB31,GNAI1,CYTH2,ERAL1,RAB8A,DENND4C,RAB10,RHEB,R
AB5A,RASGRF2,ARHGEF7,FARP1,RAP1B,DOCK8,ARL15,RGL2,RABL
3,PSD3,SEPT2,RAPGEF6,DENND6B
1.10
982
142
3
guanyl nucleotide binding
mol
ecul
ar_f
unct
ion
EIF2B4,SEPT5,RAB34,GBP3,MCF2L,ARHGEF12,LANCL2,ARHGEF25,
RGL4,RAB35,RANBP1,RHOF,EEF1A1,DNM1L,RHOBTB1,HERC2,SEPT
4,EFTUD2,RAB24,MTG1,RAB18,PLEKHG4,RALGPS2,PLEKHG5,RTKN,
NPR1,RAB31,GNAI1,CYTH2,ERAL1,RAB8A,DENND4C,RAB10,RHEB,R
AB5A,RASGRF2,ARHGEF7,FARP1,RAP1B,DOCK8,ARL15,RGL2,RABL
3,PSD3,SEPT2,RAPGEF6,DENND6B
1.10
982
142
3
G
O:
00
50
77
7
negative regulation of immune response
biol
ogic
al_p BCL6,PTPN6,RC3H1,PTPRC,PSMA1,STAT6
roce
ss
1.41
817
184
1
G
O:
00
cell motility
biol
ogic
al_p
1.08
236
793
G
O:
00
44
70
3
G
O:
00
32
56
1
G
O:
00
19
00
1
IGF1R,AVL9,LAMB1,PPIL2,RAF1,F11R,SLC16A3,GAS8,DPP4,SMAD7,
HDAC6,LEF1,EMX2,ITGA9,NISCH,ADAM8,PRPF40A,KRIT1,MINK1,PT
PN6,JAG2,AAMP,SLC16A1,JAM2,FGFR1,PDE4D,SGK1,PPM1F,PLEKH
1.09
533
597
5
2.
4
5
E
0
1
2.
4
6
E
0
1
2.
4
6
E
0
1
2.
4
7
E
0
1
2.
4
7
48
87
0
G
O:
00
51
67
4
G
O:
00
45
44
4
G
O:
00
02
52
1
G
O:
00
35
02
localization of cell
roce G5,DDX58,PTPRK,RHBDF1,NF1,COL18A1,LMNA,ITGA3,NEXN,PAFAH
ss
1B1,ESAM,USP33,FLCN,NRP1,FAP,PTEN,FYN,PHPT1,SRGAP2,TNS1,
MYLK,PTPRC,CDK6,RARRES2,NCK2,SEMA6A,CTSH,SEMA4D,CSF1R
,DGKZ,ROBO3,NAV1,SUN2,GLI3,ENG,NOX4,NUP85,ITGA5,PDGFRB,E
LP6,SETD2,PPAP2A,CLIC4,TGFBR3,CD151,PDPK1,FOXC1,STK24
IGF1R,AVL9,LAMB1,PPIL2,RAF1,F11R,SLC16A3,GAS8,DPP4,SMAD7,
HDAC6,LEF1,EMX2,ITGA9,NISCH,ADAM8,PRPF40A,KRIT1,MINK1,PT
biol
PN6,JAG2,AAMP,SLC16A1,JAM2,FGFR1,PDE4D,SGK1,PPM1F,PLEKH
ogic
G5,DDX58,PTPRK,RHBDF1,NF1,COL18A1,LMNA,ITGA3,NEXN,PAFAH
al_p
1B1,ESAM,USP33,FLCN,NRP1,FAP,PTEN,FYN,PHPT1,SRGAP2,TNS1,
roce
MYLK,PTPRC,CDK6,RARRES2,NCK2,SEMA6A,CTSH,SEMA4D,CSF1R
ss
,DGKZ,ROBO3,NAV1,SUN2,GLI3,ENG,NOX4,NUP85,ITGA5,PDGFRB,E
LP6,SETD2,PPAP2A,CLIC4,TGFBR3,CD151,PDPK1,FOXC1,STK24
8
1.08
236
793
8
fat cell differentiation
biol
ogic
ZC3H12A,CREB1,ALDH6A1,NIPBL,ZFPM2,AACS,RARRES2,C1QTNF3,
al_p
TGFB1I1,RGS2,NCOR2,ZBTB16,GATA2
roce
ss
1.24
215
760
6
leukocyte differentiation
biol
ogic SART1,BCL6,PTPN22,IL15RA,LEF1,ADAM8,MINK1,PTPN6,JAG2,RC3H
al_p 1,POLM,NF1,ZEB1,MITF,RB1,PAFAH1B1,RUNX2,NCOR1,MEF2A,PTP
roce RC,CDK6,CSF1R,GLI3,LGALS8,RUNX1,STAT6,ACIN1,NTRK1,GATA2
ss
1.14
576
64
regulation of Rho protein signal transduction
biol
ogic RAF1,BCL6,MCF2L,ARHGEF12,ARHGEF25,PLEKHG4,PLEKHG5,PAFA
al_p H1B1,FLCN,SRGAP2,FLOT1,ARHGAP29,SEMA4D,RASGRF2,ARHGEF
roce 7,FARP1
ss
1.21
102
314
5
E
0
1
2.
4
7
E
0
1
2.
4
7
E
0
1
2.
4
8
E
0
1
2.
4
8
E
-
3
G
O:
00
07
59
9
hemostasis
biol
ogic
al_p
roce
ss
FZD6,PPIL2,RAF1,GP1BB,F11R,SLC16A3,ATP2B1,CBX5,DGKA,CAPZ
B,CD9,PTPN6,PRKACA,SLC16A1,JAM2,HPS4,PRKCH,LCP2,ITGA3,GN
AI1,ZFPM2,ESAM,ANXA5,FAP,FYN,CSK,VPS45,DGKZ,KLC1,FLNA,RA
B5A,ITGA5,RAD51B,RAP1B,TLN1,DOCK8,PHF21A,HBB,PDPK1,USF1,
CD63,GATA2
1.11
607
606
5
coagulation
biol
ogic
al_p
roce
ss
FZD6,PPIL2,RAF1,GP1BB,F11R,SLC16A3,ATP2B1,CBX5,DGKA,CAPZ
B,CD9,PTPN6,PRKACA,SLC16A1,JAM2,HPS4,PRKCH,LCP2,ITGA3,GN
AI1,ZFPM2,ESAM,ANXA5,FAP,FYN,CSK,VPS45,DGKZ,KLC1,FLNA,RA
B5A,ITGA5,RAD51B,RAP1B,TLN1,DOCK8,PHF21A,HBB,PDPK1,USF1,
CD63,GATA2
1.11
607
606
5
transcription factor complex
cell
ular PBX2,GTF3C2,TBX2,MMS19,SMAD7,LEF1,GTF3C1,TBP,YY1,CREB1,Z
_co EB1,RB1,SUB1,RUNX2,NCOR1,PBX3,TCF4,NFYC,SMAD4,TCF12,ARN
mpo T,NAA16,SMAD9,USF1,FOXC1
nent
1.15
838
806
1
G
O:
00
70
71
7
poly-purine tract binding
mol
ecul
ar_f
unct
ion
RBPMS,PABPC1
2.07
796
351
5
G
O:
death receptor activity
mol
ecul
TNFRSF25,TNFRSF14
2.07
796
G
O:
00
50
81
7
G
O:
00
05
66
7
0
1
2.
4
9
E
0
1
2.
4
9
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
00
05
03
5
G
O:
00
05
45
2
G
O:
00
50
75
0
G
O:
00
31
36
9
G
O:
00
45
50
2
ar_f
unct
ion
inorganic anion exchanger activity
mol
ecul
ar_f
unct
ion
low-density lipoprotein particle receptor
binding
mol
ecul
ar_f
unct
ion
translation initiation factor binding
mol
ecul
ar_f
unct
ion
dynein binding
mol
ecul
ar_f
unct
ion
351
5
SLC4A2,SLC4A4
2.07
796
351
5
SNX17,LRPAP1
2.07
796
351
5
EIF2B4,CELF1
2.07
796
351
5
PAFAH1B1,BICD1
2.07
796
351
5
0
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
G
O:
00
16
86
1
intramolecular oxidoreductase activity,
interconverting aldoses and ketoses
mol
ecul
ar_f
unct
ion
EIF2B4,SPATA20
2.07
796
351
5
response to cytokine stimulus
biol
ogic
al_p
roce
ss
HLA-DPB1,CNTF,NUP98,SMPD4,VRK2,IL15RA,LEF1,HLA-C,HLADQA1,XAF1,PTPN6,IGBP1,STAT2,NUP210,IL13RA1,CAMK2D,SHARPI
N,TNFRSF25,NUB1,IFITM3,RPS6KA5,PAFAH1B1,IL18,CALCOCO2,NR
1H3,RQCD1,KPNB1,LIFR,DDX41,HLAF,PTPRC,NUP37,IL10RA,LEPR,CSF1R,IRF9,GAPDH,NUP85,EPOR,TN
FRSF14,PTGIS,STAT6,KPNA1,ZC3H15
1.11
218
729
8
RNA polymerase II regulatory region
sequence-specific DNA binding
mol
ecul
ar_f
unct
ion
LEF1,PAX8,CREB1,MEF2A,TCF4,SMARCA4,STAT6,CC2D1A,GATA2
1.30
710
608
2
G
O:
00
50
86
8
negative regulation of T cell activation
biol
ogic
al_p BCL6,PTPN22,PTPN6,RC3H1,CD276,GLI3,TNFRSF14
roce
ss
1.36
678
880
4
G
O:
negative regulation of cysteine-type
endopeptidase activity
biol
ogic
1.36
678
G
O:
00
34
09
7
G
O:
00
00
97
7
RAF1,LEF1,USP47,CSNK2A1,IGBP1,MDM2,HERPUD1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
20
00
11
7
G
O:
00
06
07
3
G
O:
00
72
39
5
G
O:
00
44
04
2
G
O:
00
21
53
7
al_p
roce
ss
880
4
cellular glucan metabolic process
biol
ogic
al_p GRB10,PHKG2,GAA,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.36
678
880
4
signal transduction involved in cell cycle
checkpoint
biol
ogic
al_p PSMB10,PSMB9,MDM2,CASP2,PSMC6,PSMC4,PSMA1
roce
ss
1.36
678
880
4
glucan metabolic process
biol
ogic
al_p GRB10,PHKG2,GAA,GSK3A,IGF2,PGM2,PHKG1
roce
ss
1.36
678
880
4
telencephalon development
biol
ogic
LEF1,EMX2,NF1,PAFAH1B1,PTEN,ALDH1A3,SRGAP2,MEF2A,TCTN1,
al_p
PTPRS,CDK6,GLI3,EXT1,NCOR2,ROBO2
roce
ss
1.21
740
655
1
0
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
0
E
0
1
2.
5
1
E
0
1
G
O:
00
46
34
8
amino sugar catabolic process
biol
ogic
al_p NAGK,CTBS
roce
ss
2.07
271
269
1
cardiolipin metabolic process
biol
ogic
al_p TAZ,PGS1
roce
ss
2.07
271
269
1
heart field specification
biol
ogic
al_p SMARCD3,MEF2A
roce
ss
2.07
271
269
1
G
O:
00
43
04
6
DNA methylation involved in gamete
generation
biol
ogic
al_p PLD6,PIWIL4
roce
ss
2.07
271
269
1
G
O:
protein complex localization
biol
ogic
2.07
271
G
O:
00
32
04
8
G
O:
00
03
12
8
RALGAPA2,SMAD7
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
00
31
50
3
G
O:
00
30
21
4
G
O:
00
61
29
8
G
O:
00
51
38
3
G
O:
00
07
02
0
al_p
roce
ss
269
1
hyaluronan catabolic process
biol
ogic
al_p HEXA,GUSB
roce
ss
2.07
271
269
1
retina vasculature development in cameratype eye
biol
ogic
al_p PDGFRB,CLIC4
roce
ss
2.07
271
269
1
kinetochore organization
biol
ogic
al_p CENPT,SENP6
roce
ss
2.07
271
269
1
microtubule nucleation
biol
ogic
al_p RANBP9,CLASP1
roce
ss
2.07
271
269
1
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
G
O:
00
32
87
8
regulation of establishment or maintenance
of cell polarity
biol
ogic
al_p KRIT1,RAP1B
roce
ss
2.07
271
269
1
positive regulation of systemic arterial blood
pressure
biol
ogic
al_p ENG,WNK1
roce
ss
2.07
271
269
1
regulation of lipoprotein particle clearance
biol
ogic
al_p CSK,LRPAP1
roce
ss
2.07
271
269
1
G
O:
00
60
76
6
negative regulation of androgen receptor
signaling pathway
biol
ogic
al_p PIAS2,SMARCA4
roce
ss
2.07
271
269
1
G
O:
negative regulation of extrinsic apoptotic
signaling pathway
biol
ogic
2.07
271
G
O:
00
03
08
4
G
O:
00
10
98
4
FYN,UNC5B
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
20
01
23
7
G
O:
20
00
10
4
G
O:
00
70
20
7
G
O:
00
07
50
1
G
O:
20
01
25
8
al_p
roce
ss
269
1
negative regulation of DNA-dependent DNA
replication
biol
ogic
al_p FBXW7,STAG2
roce
ss
2.07
271
269
1
protein homotrimerization
biol
ogic
al_p HSF4,DISP1
roce
ss
2.07
271
269
1
mesodermal cell fate specification
biol
ogic
al_p FGFR1,EYA2
roce
ss
2.07
271
269
1
negative regulation of cation channel
activity
biol
ogic
al_p FKBP1A,PKD2
roce
ss
2.07
271
269
1
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
G
O:
00
45
65
2
regulation of megakaryocyte differentiation
biol
ogic
al_p MEF2A,GATA2
roce
ss
2.07
271
269
1
regulation of translation in response to
stress
biol
ogic
al_p EIF2B4,FECH
roce
ss
2.07
271
269
1
protein localization to vacuole
biol
ogic
al_p VAMP7,GCC2
roce
ss
2.07
271
269
1
G
O:
00
51
30
4
chromosome separation
biol
ogic
al_p APITD1,SMARCAD1
roce
ss
2.07
271
269
1
G
O:
mitotic chromosome condensation
biol
ogic
2.07
271
G
O:
00
43
55
5
G
O:
00
72
66
5
CHMP1A,NCAPD3
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
2.
5
00
07
07
6
G
O:
00
46
82
7
G
O:
00
30
90
0
al_p
roce
ss
269
1
positive regulation of protein export from
nucleus
biol
ogic
al_p PRKACA,MDM2
roce
ss
2.07
271
269
1
forebrain development
biol
ogic LEF1,EMX2,CNP,FGFR1,CREB1,NF1,ZEB1,MAPK8IP3,PAFAH1B1,PTE
al_p N,FYN,ALDH1A3,SRGAP2,NCOR1,MEF2A,TCTN1,PTPRS,CDK6,GLI3,
roce EXT1,SMARCA4,NCOR2,SETD2,ROBO2,GATA2
ss
1.15
744
265
4
G
O:
00
30
23
4
enzyme regulator activity
mol
ecul
ar_f
unct
ion
G
O:
00
protein localization to membrane
biol
ogic
al_p
1
E
0
1
2.
5
1
E
0
1
2.
5
1
E
0
1
RAB3GAP2,EIF2B4,RALGAPA2,NLRP1,MCF2L,ARHGEF12,RNH1,LEF
1,ARHGEF25,RGL4,BCL2L13,STARD13,DNAJC10,RANBP1,SIPA1L1,K
RIT1,MINK1,CSNK2A1,IGBP1,NOD1,TBC1D2B,HERC2,TBC1D10B,TBC
1D14,TNK2,GIT2,STK4,MMP16,PLEKHG4,FAM13A,RALGPS2,PLEKHG
5,SERPINH1,NF1,RTKN,ACAP2,ANXA5,SH3BP5,RGS3,CYTH2,ARHGA
P9,IQGAP1,SRGAP2,NCOR1,PPP1R10,PRKRIP1,MAPK8,DENND4C,M
AP4K4,OAZ1,TBCD,ARHGAP29,SGSM3,UBA2,GOPC,MTMR9,CTSH,D
GKZ,C3,GRPEL2,TBC1D22A,RASGRF2,AK5,ARHGEF7,ASAP1,RGS2,
FARP1,DBF4,DOCK8,IGF2,RGL2,PSD3,BNIP2,SPRED1,CPAMD8,SEP
T2,RAPGEF6,WNK1,DENND6B
1.07
890
218
9
2.
5
1
E
0
1
CPE,VAMP7,DENND4C,FLOT1,PAK1,RAB10,FLNA,TMED2,NLGN2,PD
PK1
1.28
310
785
2.
5
2
72
65
7
G
O:
20
01
23
3
G
O:
00
02
49
5
G
O:
00
42
17
7
G
O:
20
00
10
6
roce
ss
7
regulation of apoptotic signaling pathway
biol
ogic
al_p BCL2L11,DNM1L,SEPT4,BCLAF1,FYN,LTBR,MAPK8,UNC5B
roce
ss
1.33
063
037
antigen processing and presentation of
peptide antigen via MHC class II
biol
ogic
HLA-DPB1,DYNC1I1,HLA-DQA1,HLAal_p
DMB,SEC31A,LGMN,KLC1,CANX,DYNC1I2
roce
ss
1.30
380
314
5
negative regulation of protein catabolic
process
biol
ogic
al_p UBXN1,WAC,FYN,SMAD4,FLNA
roce
ss
1.46
441
657
5
regulation of leukocyte apoptotic process
biol
ogic
al_p NOC2L,BCL6,ADAM8,PTEN,MEF2A
roce
ss
1.46
441
657
5
E
0
1
2.
5
2
E
0
1
2.
5
2
E
0
1
2.
5
4
E
0
1
2.
5
4
E
0
1
G
O:
00
43
96
7
histone H4 acetylation
biol
ogic
al_p LEF1,PHF15,ING4,MSL1,KANSL3
roce
ss
1.46
441
657
5
G
O:
00
97
19
1
extrinsic apoptotic signaling pathway
biol
ogic
al_p FYN,LTBR,UNC5B,DIABLO,TNFRSF10B
roce
ss
1.46
441
657
5
G
O:
00
51
81
7
modification of morphology or physiology of
other organism involved in symbiotic
interaction
biol
ogic
al_p LEF1,BCL2L11,SLC25A6,SMARCA4,PABPN1
roce
ss
1.46
441
657
5
embryonic organ development
biol
ogic
al_p
roce
ss
FZD6,PLCD1,COL2A1,TBX2,LEF1,PAX8,TBX18,STK4,FGFR1,ZEB1,NI
PBL,PKD2,ZFPM2,EPN2,ALDH1A3,RUNX2,MEF2A,TRIM28,RARRES2,
GLI3,TMED2,EPN1,ARNT,ERCC1,MDFI,RUNX1,SMARCA4,SETD2,PK
D1,GATA2
1.13
853
232
3
cellular carbohydrate metabolic process
biol
GK5,GALK2,NAGK,ISYNA1,GPCPD1,GRB10,PTEN,IDH1,NCOR1,SME
ogic
K1,PHKG2,C1QTNF3,ARNT,EXT1,GAA,GSK3A,IGF2,PGM2,PHKG1,RB
al_p
KS
roce
1.17
664
912
6
G
O:
00
48
56
8
G
O:
00
44
2.
5
4
E
0
1
2.
5
4
E
0
1
2.
5
4
E
0
1
2.
5
4
E
0
1
2.
5
6
E
26
2
G
O:
00
19
90
4
G
O:
00
72
55
8
G
O:
00
02
13
9
G
O:
00
05
86
2
ss
protein domain specific binding
mol
ecul
ar_f
unct
ion
FZD6,FAM189B,CADM1,NLRP1,LUC7L,PTPN22,HGS,LEF1,USP47,PT
PN6,VASP,NOD1,SHISA5,TNK2,USHBP1,REPS1,NIPBL,PKD2,CASP2,
STRN4,PLEKHA2,SENP2,CHMP1A,ADAM15,SH3BP5,PTEN,RUNX2,PX
N,KPNB1,MEF2A,SH3BP2,SRRM2,TRIM28,ERC1,SRSF10,ERCC1,CAR
D14,TLN1,SON,CTTNBP2,TGFBR3,PKD1,GATA2
NLRP1 inflammasome complex
cell
ular
_co NLRP1
mpo
nent
3.49
833
194
3
stereocilia coupling link
cell
ular
_co VEZT
mpo
nent
3.49
833
194
3
muscle thin filament tropomyosin
cell
ular
_co TPM4
mpo
nent
3.49
833
194
3
1.11
049
866
6
0
1
2.
5
6
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
G
O:
00
16
60
2
G
O:
00
44
61
5
G
O:
00
45
27
3
G
O:
00
70
82
0
G
O:
00
32
CCAAT-binding factor complex
cell
ular
_co NFYC
mpo
nent
3.49
833
194
3
nuclear pore nuclear basket
cell
ular
_co NUP98
mpo
nent
3.49
833
194
3
respiratory chain complex II
cell
ular
_co SDHA
mpo
nent
3.49
833
194
3
tertiary granule
cell
ular
_co ADAM8
mpo
nent
3.49
833
194
3
phagolysosome
cell
ular
ADAM8
_co
mpo
3.49
833
194
3
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
01
0
G
O:
00
43
65
6
G
O:
00
30
89
1
G
O:
00
33
64
6
G
O:
00
00
44
4
nent
intracellular region of host
cell
ular
_co BICD1
mpo
nent
3.49
833
194
3
VCB complex
cell
ular
_co USP33
mpo
nent
3.49
833
194
3
host intracellular part
cell
ular
_co BICD1
mpo
nent
3.49
833
194
3
MIS12/MIND type complex
cell
ular
_co DSN1
mpo
nent
3.49
833
194
3
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
G
O:
00
35
18
9
G
O:
00
72
48
7
G
O:
00
71
54
7
G
O:
00
05
74
9
G
O:
00
00
Rb-E2F complex
cell
ular
_co RB1
mpo
nent
3.49
833
194
3
MSL complex
cell
ular
_co MSL1
mpo
nent
3.49
833
194
3
piP-body
cell
ular
_co PIWIL4
mpo
nent
3.49
833
194
3
mitochondrial respiratory chain complex II
cell
ular
_co SDHA
mpo
nent
3.49
833
194
3
Golgi cis cisterna
cell
ular
NECAB3
_co
mpo
3.49
833
194
3
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
13
7
G
O:
00
02
14
1
G
O:
00
02
14
2
G
O:
00
97
36
1
G
O:
00
45
25
7
nent
stereocilia ankle link
cell
ular
_co VEZT
mpo
nent
3.49
833
194
3
stereocilia ankle link complex
cell
ular
_co VEZT
mpo
nent
3.49
833
194
3
CIA complex
cell
ular
_co MMS19
mpo
nent
3.49
833
194
3
succinate dehydrogenase complex
(ubiquinone)
cell
ular
_co SDHA
mpo
nent
3.49
833
194
3
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
G
O:
00
34
09
8
G
O:
00
05
95
4
G
O:
00
97
13
6
G
O:
00
00
01
5
G
O:
00
45
Cdc48p-Npl4p-Ufd1p AAA ATPase complex
cell
ular
_co UBXN1
mpo
nent
3.49
833
194
3
calcium- and calmodulin-dependent protein
kinase complex
cell
ular
_co CAMK2D
mpo
nent
3.49
833
194
3
Bcl-2 family protein complex
cell
ular
_co BCL2L11
mpo
nent
3.49
833
194
3
phosphopyruvate hydratase complex
cell
ular
_co ENO4
mpo
nent
3.49
833
194
3
fumarate reductase complex
cell
ular
SDHA
_co
mpo
3.49
833
194
3
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
28
3
G
O:
00
00
22
0
G
O:
00
70
02
2
G
O:
00
45
28
1
G
O:
00
06
65
0
nent
vacuolar proton-transporting V-type
ATPase, V0 domain
cell
ular
_co ATP6V0A1
mpo
nent
3.49
833
194
3
transforming growth factor beta receptor
homodimeric complex
cell
ular
_co ENG
mpo
nent
3.49
833
194
3
succinate dehydrogenase complex
cell
ular
_co SDHA
mpo
nent
3.49
833
194
3
glycerophospholipid metabolic process
biol
ogic TAZ,PLD1,GPAA1,PGS1,SMPD4,PIGS,PIGG,PIGN,CHKB,GPAT2,PAFA
al_p H1B1,GPCPD1,PLD6,MTMR14,PTEN,CSF1R,MBOAT2,LPCAT1,PDGF
roce RB,PCYT1A,PIGO,ALG9,PLA2G16
ss
1.16
056
384
8
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
7
E
0
1
2.
5
8
E
0
1
G
O:
00
42
30
6
G
O:
20
00
14
6
G
O:
00
43
93
3
G
O:
00
51
40
3
2.
5
8
E
0
1
2.
5
8
E
0
1
regulation of protein import into nucleus
biol
ogic
RBPMS,DDX58,NF1,PKD2,SMAD4,C1QTNF3,FLNA,GLI3,MDFI,PKD1,K
al_p
PNA1,UBR5
roce
ss
1.24
362
761
5
negative regulation of cell motility
biol
ogic
SMAD7,NISCH,KRIT1,PTPRK,NF1,FLCN,PTEN,SRGAP2,ENG,CLIC4,T
al_p
GFBR3,STK24
roce
ss
1.24
362
761
5
macromolecular complex subunit
organization
CRBN,IGF1R,RAF1,SFSWAP,TAZ,SART1,SHMT2,GPAA1,CLNS1A,NU
P98,HDAC6,ARPC4TTLL3,GLS,BCL2L11,COG4,PAM,DDX23,CAPZB,RHOF,ACTR3,VASP,
NOD1,TTC19,DNM1L,UPF1,RC3H1,PPP5C,BCLAF1,HSF4,DISP1,CELF
biol
1,SF3A2,SHARPIN,RNF8,MDM2,FKBP1A,PPM1F,SSH2,RPL27,MAGI1,
ogic
PIH1D1,RPL9,ADSL,MITF,RB1,PRMT5,PUM2,ARPC2,DDX6,BICD1,PL
al_p
D6,RPL24,RPL37A,SMARCD3,PXN,FECH,ERAL1,WASH4P,VILL,TRIM2
roce
8,TBCD,TSPAN4,COX14,ZNF148,GOPC,RANBP9,ATPAF2,PAK1,NCK2
ss
,TCF4,ACTR2,SRSF10,SMAD4,KLC1,C1QTNF3,EZR,RPL4,CENPT,FH
OD1,FLNA,HGSNAT,BCS1L,TMED2,NOX4,MTRF1L,CIRBP,NCBP2,TG
S1,SMARCA4,RPLP0,KCTD2,SNRPE,TWF1,AMFR,KCTD17,TFAM,SHP
RH,HBB,TGFBR3,UQCRH,SENP6,SSH1,FMOD,SMARCAD1,CLASP1
1.06
442
920
4
2.
5
8
E
0
1
stress-activated MAPK cascade
biol
ogic IGF1R,MINK1,IGBP1,NOD1,TAB2,CREB1,RPS6KA5,MAPK8IP3,PAFAH
al_p 1B1,LTBR,NCOR1,MEF2A,MAPK8,MAP4K4,PAK1,MDFI,FGF14,PDCD4
roce ,DUSP6
ss
1.17
963
141
6
2.
5
9
E
0
1
G
O:
00
07
24
9
I-kappaB kinase/NF-kappaB cascade
biol
ogic NOD1,PPP5C,SHISA5,MIB2,TAB2,SHARPIN,FKBP1A,PLEKHG5,PLK2,I
al_p KBKB,LTBR,ERC1,C1QTNF3,TANK,APOL3,FLNA,TNFRSF10B,PDPK1,
roce CC2D1A
ss
1.17
963
141
6
collagen metabolic process
biol
ogic
al_p MMP16,SERPINH1,IL18,ADAM15,TENC1,PDGFRB
roce
ss
1.39
372
060
3
regulation of phosphatidylinositol 3-kinase
cascade
biol
ogic
al_p PTPN6,FGFR1,PTEN,NCOR1,SEMA4D,PDGFRB
roce
ss
1.39
372
060
3
G
O:
00
70
37
2
regulation of ERK1 and ERK2 cascade
biol
ogic
PTPN6,NOD1,FLCN,FBXW7,CSK,CSF1R,C1QTNF3,NOX4,PDGFRB,NT
al_p
RK1,DUSP6
roce
ss
1.25
592
336
8
G
O:
embryonic limb morphogenesis
biol
ogic
1.25
592
G
O:
00
32
96
3
G
O:
00
14
06
6
PBX2,TBX2,LEF1,FGFR1,NIPBL,ACD,LMBR1,GLI3,SMARCA4,ZBTB16,
C2CD3
2.
5
9
E
0
1
2.
5
9
E
0
1
2.
5
9
E
0
1
2.
6
0
E
0
1
2.
6
00
30
32
6
G
O:
00
35
11
3
G
O:
00
04
52
7
G
O:
00
02
28
7
G
O:
00
10
88
3
al_p
roce
ss
336
8
embryonic appendage morphogenesis
biol
ogic
PBX2,TBX2,LEF1,FGFR1,NIPBL,ACD,LMBR1,GLI3,SMARCA4,ZBTB16,
al_p
C2CD3
roce
ss
1.25
592
336
8
exonuclease activity
mol
ecul
ar_f
unct
ion
1.35
067
628
5
alpha-beta T cell activation involved in
immune response
biol
ogic
al_p BCL6,LEF1,RC3H1,STAT6
roce
ss
1.53
972
942
8
regulation of lipid storage
biol
ogic
al_p ZC3H12A,NR1H3,FBXW7,C3
roce
ss
1.53
972
942
8
XRN1,DIS3L,PAN2,PARN,REXO2,POLG,ERI3
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
G
O:
20
01
25
7
regulation of cation channel activity
biol
ogic
al_p CAMK2D,FKBP1A,PKD2,IKBKB
roce
ss
1.53
972
942
8
intracellular estrogen receptor signaling
pathway
biol
ogic
al_p KANK2,RQCD1,PAK1,CRIPAK
roce
ss
1.53
972
942
8
regulation of chondrocyte differentiation
biol
ogic
al_p GLG1,RUNX2,GLI3,ZBTB16
roce
ss
1.53
972
942
8
G
O:
00
00
57
8
embryonic axis specification
biol
ogic
al_p PLD6,SMAD4,TMED2,C2CD3
roce
ss
1.53
972
942
8
G
O:
nucleotide phosphorylation
biol
ogic
1.53
972
G
O:
00
30
52
0
G
O:
00
32
33
0
CMPK2,PNKP,DTYMK,AK5
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
00
46
93
9
G
O:
00
32
09
1
G
O:
00
02
24
4
G
O:
00
14
81
2
G
O:
00
32
88
1
al_p
roce
ss
942
8
negative regulation of protein binding
biol
ogic
al_p LEF1,SENP2,MAPK8,LRPAP1
roce
ss
1.53
972
942
8
hematopoietic progenitor cell differentiation
biol
ogic
al_p FLCN,PTPRC,CDK6,RUNX1
roce
ss
1.53
972
942
8
muscle cell migration
biol
ogic
al_p AAMP,NRP1,NOX4,PDGFRB
roce
ss
1.53
972
942
8
regulation of polysaccharide metabolic
process
biol
ogic
al_p GRB10,PHKG2,GSK3A,IGF2
roce
ss
1.53
972
942
8
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
G
O:
00
02
29
3
alpha-beta T cell differentiation involved in
immune response
biol
ogic
al_p BCL6,LEF1,RC3H1,STAT6
roce
ss
1.53
972
942
8
melanocyte differentiation
biol
ogic
al_p HPS4,MITF,MEF2A,GLI3
roce
ss
1.53
972
942
8
regulation of DNA-dependent transcription,
elongation
biol
ogic
al_p SUPT5H,SUPT4H1,PAF1,WDR61
roce
ss
1.53
972
942
8
G
O:
00
04
11
4
3,5-cyclic-nucleotide phosphodiesterase
activity
mol
ecul
ar_f
unct
ion
PDE7B,PDE4D,PDE8A
1.68
834
535
6
G
O:
metallocarboxypeptidase activity
mol
ecul
CPE,CPM,AGBL5
1.68
834
G
O:
00
30
31
8
G
O:
00
32
78
4
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
0
E
0
1
2.
6
1
E
0
1
2.
6
00
04
18
1
G
O:
00
09
99
1
G
O:
00
30
22
5
G
O:
00
01
89
3
G
O:
00
32
22
8
ar_f
unct
ion
535
6
response to extracellular stimulus
biol
ogic IGF1R,TNRC6A,BDNF,SUPT5H,HDAC6,ASNS,NPC1,ATG4B,TBC1D14,
al_p WAC,GSDMD,MDM2,ZEB1,ATG12,ADSL,CHMP1A,AACS,MEF2A,OXC
roce T1,ERCC1,NRBP2,NTRK1,ATG3,RRP8,USF1
ss
1.14
954
202
2
macrophage differentiation
biol
ogic
al_p RB1,CSF1R,GATA2
roce
ss
1.68
407
906
2
maternal placenta development
biol
ogic
al_p RXRB,TMED2,EPOR
roce
ss
1.68
407
906
2
regulation of synaptic transmission,
GABAergic
biol
ogic
al_p NISCH,NF1,NLGN2
roce
ss
1.68
407
906
2
1
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
G
O:
00
46
82
5
regulation of protein export from nucleus
biol
ogic
al_p UHMK1,PRKACA,MDM2
roce
ss
1.68
407
906
2
regulation of hormone metabolic process
biol
ogic
al_p IGF1R,PAX8,ARNT
roce
ss
1.68
407
906
2
glutamine family amino acid catabolic
process
biol
ogic
al_p GLS,DDAH1,DDAH2
roce
ss
1.68
407
906
2
G
O:
00
10
71
8
positive regulation of epithelial to
mesenchymal transition
biol
ogic
al_p LEF1,SMAD4,TGFB1I1
roce
ss
1.68
407
906
2
G
O:
negative regulation of smoothened signaling
pathway
biol
ogic
1.68
407
G
O:
00
32
35
0
G
O:
00
09
06
5
RB1,RUNX2,GLI3
2.
6
2
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
2.
6
00
45
87
9
G
O:
00
31
11
1
G
O:
19
01
68
1
G
O:
00
70
58
8
G
O:
00
06
51
8
al_p
roce
ss
906
2
negative regulation of microtubule
polymerization or depolymerization
biol
ogic
al_p HDAC6,TBCD,CLASP1
roce
ss
1.68
407
906
2
sulfur compound binding
mol
ecul
ar_f
unct
ion
1.20
596
096
9
calcium ion transmembrane transport
biol
ogic ATP2B1,SLC11A2,CAMK2D,TPCN2,SGK1,FKBP1A,PKD2,PHPT1,CAC
al_p NB1,TMEM66,TRPM7,PDGFRB,CACNB3,CACNA2D1,CACNA2D4,PKD
roce 1
ss
1.19
756
733
3
peptide metabolic process
biol
ogic
al_p PAM,DNPEP,FKBP1A,TPP1,IDH1,CTNS,CTSH,LONP2,SPCS3
roce
ss
1.28
993
289
8
ADAMTS1,HSD17B12,HDGF,AAMP,FGFR1,THBS3,PAFAH1B1,NRP1,P
TPRF,PTPRC,ABI3BP,LRPAP1,FGF14,COL13A1,TGFBR3
2
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
2.
6
2
E
0
1
G
O:
00
16
74
1
transferase activity, transferring one-carbon
groups
mol
ecul
ar_f
unct
ion
regulation of phospholipase activity
biol
ogic
al_p PRKACA,FGFR1,ADCY4,CREB1,BICD1,RGS2,PDGFRB,NTRK1
roce
ss
1.31
440
317
Toll signaling pathway
biol
ogic
al_p NOD1,TAB2,CREB1,RPS6KA5,IKBKB,MEF2A,MAPK8,DUSP6
roce
ss
1.31
440
317
G
O:
00
06
47
3
protein acetylation
biol
ogic
NOC2L,LEF1,DR1,PHF15,RPS6KA5,FLCN,ING4,MSL1,NAA10,SMARC
al_p
A4,NAA16,KANSL3,GATA2
roce
ss
1.22
478
477
2
G
O:
WASH complex
cell
ular
1.99
904
G
O:
00
10
51
7
G
O:
00
08
06
3
SHMT2,EED,AMT,EHMT1,PRMT10,METTL3,PRMT5,NTMT1,SETD8,N6
AMT1,WDR4,TGS1,THUMPD2,SETD2,FTSJ3,RRP8,HEMK1
CAPZB,WASH4P
1.18
971
486
2
2.
6
2
E
0
1
2.
6
3
E
0
1
2.
6
3
E
0
1
2.
6
3
E
0
1
2.
6
00
71
20
3
G
O:
00
90
54
4
G
O:
00
30
13
2
G
O:
00
31
14
3
G
O:
00
00
14
5
_co
mpo
nent
682
5
BAF-type complex
cell
ular
_co SMARCD3,SMARCA4
mpo
nent
1.99
904
682
5
clathrin coat of coated pit
cell
ular
_co CLTCL1,CLTB
mpo
nent
1.99
904
682
5
pseudopodium
cell
ular
_co RAF1,CNP
mpo
nent
1.99
904
682
5
exocyst
cell
ular
_co RAB10,SEPT2
mpo
nent
1.99
904
682
5
4
E
0
1
2.
6
4
E
0
1
2.
6
4
E
0
1
2.
6
4
E
0
1
2.
6
4
E
0
1
G
O:
00
04
63
4
phosphopyruvate hydratase activity
mol
ecul
ar_f
unct
ion
inositol tetrakisphosphate phosphatase
activity
mol
ecul
ar_f
unct
ion
four-way junction DNA binding
mol
ecul
ar_f
unct
ion
G
O:
00
80
03
2
G
O:
G
O:
00
52
74
3
G
O:
00
00
40
0
ENO4
3.37
669
071
2
PTEN
3.37
669
071
2
YY1
3.37
669
071
2
methyl jasmonate esterase activity
mol
ecul
ar_f
unct
ion
CES2
3.37
669
071
2
estrogen receptor activity
mol
ecul
LEF1
3.37
669
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
30
28
4
G
O:
00
70
81
5
G
O:
00
04
11
1
G
O:
00
80
03
1
G
O:
00
04
42
7
ar_f
unct
ion
peptidyl-lysine 5-dioxygenase activity
mol
ecul
ar_f
unct
ion
creatine kinase activity
mol
ecul
ar_f
unct
ion
methyl salicylate esterase activity
mol
ecul
ar_f
unct
ion
inorganic diphosphatase activity
mol
ecul
ar_f
unct
ion
071
2
PLOD2
3.37
669
071
2
CKB
3.37
669
071
2
CES2
3.37
669
071
2
PPA2
3.37
669
071
2
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
43
51
5
kinetochore binding
mol
ecul
ar_f
unct
ion
S-methyl-5-thioribose-1-phosphate
isomerase activity
mol
ecul
ar_f
unct
ion
very-low-density lipoprotein particle receptor
binding
mol
ecul
ar_f
unct
ion
G
O:
00
04
12
7
G
O:
G
O:
00
46
52
3
G
O:
00
70
32
6
CLASP1
3.37
669
071
2
EIF2B4
3.37
669
071
2
LRPAP1
3.37
669
071
2
cytidylate kinase activity
mol
ecul
ar_f
unct
ion
CMPK2
3.37
669
071
2
calmodulin-dependent protein phosphatase
activity
mol
ecul
PPM1F
3.37
669
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
33
19
2
G
O:
00
05
53
4
G
O:
00
05
04
7
G
O:
00
15
18
4
G
O:
00
30
49
2
ar_f
unct
ion
galactose binding
mol
ecul
ar_f
unct
ion
signal recognition particle binding
mol
ecul
ar_f
unct
ion
L-cystine transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
hemoglobin binding
mol
ecul
ar_f
unct
ion
071
2
ENG
3.37
669
071
2
SRP9
3.37
669
071
2
CTNS
3.37
669
071
2
HBB
3.37
669
071
2
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
00
10
4
succinate dehydrogenase activity
mol
ecul
ar_f
unct
ion
polynucleotide 5-hydroxyl-kinase activity
mol
ecul
ar_f
unct
ion
glycerol kinase activity
mol
ecul
ar_f
unct
ion
G
O:
00
04
56
3
G
O:
G
O:
00
51
73
1
G
O:
00
04
37
0
SDHA
3.37
669
071
2
PNKP
3.37
669
071
2
GK5
3.37
669
071
2
beta-N-acetylhexosaminidase activity
mol
ecul
ar_f
unct
ion
HEXA
3.37
669
071
2
procollagen-proline 4-dioxygenase activity
mol
ecul
P4HB
3.37
669
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
04
65
6
G
O:
00
08
17
4
G
O:
00
04
09
5
G
O:
00
22
82
1
G
O:
00
04
68
7
ar_f
unct
ion
mRNA methyltransferase activity
mol
ecul
ar_f
unct
ion
carnitine O-palmitoyltransferase activity
mol
ecul
ar_f
unct
ion
potassium ion antiporter activity
mol
ecul
ar_f
unct
ion
myosin light chain kinase activity
mol
ecul
ar_f
unct
ion
071
2
METTL3
3.37
669
071
2
CPT1B
3.37
669
071
2
SLC9A8
3.37
669
071
2
MYLK
3.37
669
071
2
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
16
63
5
oxidoreductase activity, acting on the CHCH group of donors, quinone or related
compound as acceptor
mol
ecul
ar_f
unct
ion
ciliary neurotrophic factor receptor activity
mol
ecul
ar_f
unct
ion
pantothenate kinase activity
mol
ecul
ar_f
unct
ion
G
O:
00
36
03
3
G
O:
G
O:
00
04
89
7
G
O:
00
04
59
4
SDHA
3.37
669
071
2
LIFR
3.37
669
071
2
PANK3
3.37
669
071
2
mediator complex binding
mol
ecul
ar_f
unct
ion
NIPBL
3.37
669
071
2
arginine binding
mol
ecul
RARS
3.37
669
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
34
61
8
G
O:
00
04
94
8
G
O:
00
45
56
9
G
O:
00
90
48
2
G
O:
00
16
41
6
ar_f
unct
ion
calcitonin receptor activity
mol
ecul
ar_f
unct
ion
TRAIL binding
mol
ecul
ar_f
unct
ion
vitamin transmembrane transporter activity
mol
ecul
ar_f
unct
ion
O-palmitoyltransferase activity
mol
ecul
ar_f
unct
ion
071
2
CRCP
3.37
669
071
2
TNFRSF10B
3.37
669
071
2
SLC23A2
3.37
669
071
2
CPT1B
3.37
669
071
2
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
04
30
5
ethanolamine kinase activity
mol
ecul
ar_f
unct
ion
AP-2 adaptor complex binding
mol
ecul
ar_f
unct
ion
prostaglandin-E synthase activity
mol
ecul
ar_f
unct
ion
G
O:
00
03
94
5
G
O:
G
O:
00
35
61
2
G
O:
00
50
22
0
CHKB
3.37
669
071
2
AAK1
3.37
669
071
2
PTGES2
3.37
669
071
2
N-acetyllactosamine synthase activity
mol
ecul
ar_f
unct
ion
B4GALT4
3.37
669
071
2
methyl indole-3-acetate esterase activity
mol
ecul
CES2
3.37
669
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
80
03
0
G
O:
00
31
48
9
G
O:
00
48
49
5
G
O:
00
15
37
9
G
O:
00
03
83
1
ar_f
unct
ion
myosin V binding
mol
ecul
ar_f
unct
ion
Roundabout binding
mol
ecul
ar_f
unct
ion
potassium:chloride symporter activity
mol
ecul
ar_f
unct
ion
beta-N-acetylglucosaminylglycopeptide
beta-1,4-galactosyltransferase activity
mol
ecul
ar_f
unct
ion
071
2
RAB10
3.37
669
071
2
TGFB1I1
3.37
669
071
2
SLC12A6
3.37
669
071
2
WDFY3
3.37
669
071
2
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
43
55
9
insulin binding
mol
ecul
ar_f
unct
ion
IGF1R
3.37
669
071
2
response to ether
biol
ogic
al_p MDM2
roce
ss
3.36
815
812
3
base-excision repair, gap-filling
biol
ogic
al_p POLG
roce
ss
3.36
815
812
3
G
O:
00
35
64
6
endosome to melanosome transport
biol
ogic
al_p BLOC1S5
roce
ss
3.36
815
812
3
G
O:
L-cystine transport
biol
ogic
3.36
815
G
O:
00
45
47
2
G
O:
00
06
28
7
CTNS
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
15
81
1
G
O:
00
90
38
5
G
O:
00
06
23
5
G
O:
00
72
55
3
G
O:
19
00
10
3
al_p
roce
ss
812
3
phagosome-lysosome fusion
biol
ogic
al_p RAB34
roce
ss
3.36
815
812
3
dTTP biosynthetic process
biol
ogic
al_p DTYMK
roce
ss
3.36
815
812
3
terminal button organization
biol
ogic
al_p NLGN2
roce
ss
3.36
815
812
3
positive regulation of endoplasmic reticulum
unfolded protein response
biol
ogic
al_p XBP1
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
46
98
4
regulation of hemoglobin biosynthetic
process
biol
ogic
al_p FECH
roce
ss
3.36
815
812
3
protein glycosylation in Golgi
biol
ogic
al_p LMF1
roce
ss
3.36
815
812
3
cytokinesis after meiosis
biol
ogic
al_p ACTR3
roce
ss
3.36
815
812
3
G
O:
00
32
76
3
regulation of mast cell cytokine production
biol
ogic
al_p BCL6
roce
ss
3.36
815
812
3
G
O:
central nervous system vasculogenesis
biol
ogic
3.36
815
G
O:
00
33
57
8
G
O:
00
33
20
6
ENG
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
22
00
9
G
O:
00
72
13
1
al_p
roce
ss
812
3
kidney mesenchyme morphogenesis
biol
ogic
al_p SMAD4
roce
ss
3.36
815
812
3
G
O:
00
51
79
0
short-chain fatty acid biosynthetic process
biol
ogic
al_p THNSL2
roce
ss
3.36
815
812
3
G
O:
00
72
36
7
regulation of lipid transport by regulation of
transcription from RNA polymerase II
promoter
biol
ogic
al_p NCOR1
roce
ss
3.36
815
812
3
G
O:
00
72
10
8
positive regulation of mesenchymal to
epithelial transition involved in metanephros
morphogenesis
biol
ogic
al_p PAX8
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
55
00
5
ventricular cardiac myofibril development
biol
ogic
al_p MEF2A
roce
ss
3.36
815
812
3
hematopoietic stem cell migration
biol
ogic
al_p PTPRC
roce
ss
3.36
815
812
3
regulation of pinocytosis
biol
ogic
al_p NR1H3
roce
ss
3.36
815
812
3
G
O:
00
10
98
9
negative regulation of low-density
lipoprotein particle clearance
biol
ogic
al_p CSK
roce
ss
3.36
815
812
3
G
O:
Ral protein signal transduction
biol
ogic
3.36
815
G
O:
00
35
70
1
G
O:
00
48
54
8
RALGAPA2
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
32
48
4
G
O:
00
72
19
9
G
O:
00
70
34
4
G
O:
00
72
19
4
G
O:
00
48
36
9
al_p
roce
ss
812
3
regulation of mesenchymal cell proliferation
involved in ureter development
biol
ogic
al_p TBX18
roce
ss
3.36
815
812
3
regulation of fat cell proliferation
biol
ogic
al_p GATA2
roce
ss
3.36
815
812
3
kidney smooth muscle tissue development
biol
ogic
al_p PKD2
roce
ss
3.36
815
812
3
lateral mesoderm morphogenesis
biol
ogic
al_p FGFR1
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
43
30
7
eosinophil activation
biol
ogic
al_p VAMP7
roce
ss
3.36
815
812
3
positive regulation of calcineurin-NFAT
signaling cascade
biol
ogic
al_p LMCD1
roce
ss
3.36
815
812
3
negative regulation of interferon-gammamediated signaling pathway
biol
ogic
al_p NR1H3
roce
ss
3.36
815
812
3
G
O:
00
61
03
8
uterus morphogenesis
biol
ogic
al_p NIPBL
roce
ss
3.36
815
812
3
G
O:
response to erythropoietin
biol
ogic
3.36
815
G
O:
00
70
88
6
G
O:
00
60
33
6
EPOR
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
36
01
7
G
O:
00
35
18
8
G
O:
00
30
22
2
G
O:
00
00
42
9
G
O:
20
00
00
9
al_p
roce
ss
812
3
hatching
biol
ogic
al_p SMARCA4
roce
ss
3.36
815
812
3
eosinophil differentiation
biol
ogic
al_p GATA2
roce
ss
3.36
815
812
3
carbon catabolite regulation of transcription
from RNA polymerase II promoter
biol
ogic
al_p USF1
roce
ss
3.36
815
812
3
negative regulation of protein localization to
cell surface
biol
ogic
al_p LEPROT
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
60
59
4
mammary gland specification
biol
ogic
al_p GLI3
roce
ss
3.36
815
812
3
cardiac right ventricle formation
biol
ogic
al_p SMARCD3
roce
ss
3.36
815
812
3
protection from non-homologous end joining
at telomere
biol
ogic
al_p ACD
roce
ss
3.36
815
812
3
G
O:
00
71
31
6
cellular response to nicotine
biol
ogic
al_p NTRK1
roce
ss
3.36
815
812
3
G
O:
positive regulation of Ral GTPase activity
biol
ogic
3.36
815
G
O:
00
03
21
9
G
O:
00
31
84
8
RALGAPA2
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
32
85
2
G
O:
00
06
56
4
G
O:
00
19
26
2
G
O:
00
19
47
4
G
O:
00
97
05
6
al_p
roce
ss
812
3
L-serine biosynthetic process
biol
ogic
al_p SHMT2
roce
ss
3.36
815
812
3
N-acetylneuraminate catabolic process
biol
ogic
al_p NAGK
roce
ss
3.36
815
812
3
L-lysine catabolic process to acetyl-CoA
biol
ogic
al_p DLST
roce
ss
3.36
815
812
3
selenocysteinyl-tRNA(Sec) biosynthetic
process
biol
ogic
al_p PSTK
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
43
48
5
endosome to pigment granule transport
biol
ogic
al_p BLOC1S5
roce
ss
3.36
815
812
3
nuclear RNA surveillance
biol
ogic
al_p XRN1
roce
ss
3.36
815
812
3
negative regulation of cardiac muscle tissue
development
biol
ogic
al_p GSK3A
roce
ss
3.36
815
812
3
G
O:
00
97
24
2
beta-amyloid clearance
biol
ogic
al_p LRPAP1
roce
ss
3.36
815
812
3
G
O:
regulation of determination of dorsal identity
biol
ogic
3.36
815
G
O:
00
71
02
7
G
O:
00
55
02
6
MAPK8
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
20
00
01
5
G
O:
00
50
92
3
G
O:
00
09
31
3
G
O:
00
72
59
2
G
O:
00
02
27
8
al_p
roce
ss
812
3
regulation of negative chemotaxis
biol
ogic
al_p ROBO2
roce
ss
3.36
815
812
3
oligosaccharide catabolic process
biol
ogic
al_p CTBS
roce
ss
3.36
815
812
3
oxygen metabolic process
biol
ogic
al_p FMO2
roce
ss
3.36
815
812
3
eosinophil activation involved in immune
response
biol
ogic
al_p VAMP7
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
42
89
1
antibiotic transport
biol
ogic
al_p MFSD10
roce
ss
3.36
815
812
3
lysosome localization
biol
ogic
al_p HDAC6
roce
ss
3.36
815
812
3
negative regulation of T cell mediated
cytotoxicity
biol
ogic
al_p PTPRC
roce
ss
3.36
815
812
3
G
O:
00
33
18
2
regulation of histone ubiquitination
biol
ogic
al_p UBR5
roce
ss
3.36
815
812
3
G
O:
dTTP metabolic process
biol
ogic
3.36
815
G
O:
00
32
41
8
G
O:
00
01
91
5
DTYMK
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
46
07
5
G
O:
00
00
43
6
G
O:
00
46
53
3
G
O:
00
60
02
7
G
O:
00
35
78
8
al_p
roce
ss
812
3
carbon catabolite activation of transcription
from RNA polymerase II promoter
biol
ogic
al_p USF1
roce
ss
3.36
815
812
3
negative regulation of photoreceptor cell
differentiation
biol
ogic
al_p CNTF
roce
ss
3.36
815
812
3
convergent extension involved in
gastrulation
biol
ogic
al_p NPHP3
roce
ss
3.36
815
812
3
cell migration involved in metanephros
development
biol
ogic
al_p PDGFRB
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
03
09
6
renal sodium ion transport
biol
ogic
al_p SGK1
roce
ss
3.36
815
812
3
multivesicular body sorting pathway
biol
ogic
al_p SYTL4
roce
ss
3.36
815
812
3
vesicle fusion with Golgi apparatus
biol
ogic
al_p VAMP7
roce
ss
3.36
815
812
3
G
O:
20
01
22
4
positive regulation of neuron migration
biol
ogic
al_p SEMA6A
roce
ss
3.36
815
812
3
G
O:
regulation of endodermal cell fate
specification
biol
ogic
3.36
815
G
O:
00
71
98
5
G
O:
00
48
28
0
DUSP6
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
42
66
3
G
O:
00
07
16
1
G
O:
00
17
01
4
G
O:
00
35
60
8
G
O:
00
72
28
9
al_p
roce
ss
812
3
calcium-independent cell-matrix adhesion
biol
ogic
al_p PKD1
roce
ss
3.36
815
812
3
protein nitrosylation
biol
ogic
al_p GAPDH
roce
ss
3.36
815
812
3
protein deglutamylation
biol
ogic
al_p AGBL5
roce
ss
3.36
815
812
3
metanephric nephron tubule formation
biol
ogic
al_p PAX8
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
61
00
2
negative regulation of dendritic spine
morphogenesis
biol
ogic
al_p PTEN
roce
ss
3.36
815
812
3
DNA replication involved in S phase
biol
ogic
al_p INO80
roce
ss
3.36
815
812
3
regulation of chromatin binding
biol
ogic
al_p SENP2
roce
ss
3.36
815
812
3
G
O:
20
00
11
1
positive regulation of macrophage apoptotic
process
biol
ogic
al_p MEF2A
roce
ss
3.36
815
812
3
G
O:
ADP metabolic process
biol
ogic
3.36
815
G
O:
00
33
26
0
G
O:
00
35
56
1
AK5
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
46
03
1
G
O:
00
46
95
2
G
O:
00
46
53
2
G
O:
00
48
86
1
G
O:
00
14
04
5
al_p
roce
ss
812
3
ketone body catabolic process
biol
ogic
al_p OXCT1
roce
ss
3.36
815
812
3
regulation of photoreceptor cell
differentiation
biol
ogic
al_p CNTF
roce
ss
3.36
815
812
3
leukemia inhibitory factor signaling pathway
biol
ogic
al_p LIFR
roce
ss
3.36
815
812
3
establishment of endothelial blood-brain
barrier
biol
ogic
al_p ENG
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
31
42
7
response to methotrexate
biol
ogic
al_p ASNS
roce
ss
3.36
815
812
3
traversing start control point of mitotic cell
cycle
biol
ogic
al_p MDM2
roce
ss
3.36
815
812
3
myosin filament organization
biol
ogic
al_p ACTR3
roce
ss
3.36
815
812
3
G
O:
00
09
41
4
response to water deprivation
biol
ogic
al_p CD9
roce
ss
3.36
815
812
3
G
O:
chloride ion homeostasis
biol
ogic
3.36
815
G
O:
00
07
08
9
G
O:
00
31
03
3
CKB
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
55
06
4
G
O:
00
32
85
9
al_p
roce
ss
812
3
activation of Ral GTPase activity
biol
ogic
al_p RALGAPA2
roce
ss
3.36
815
812
3
regulation of store-operated calcium entry
biol
ogic
al_p TMEM66
roce
ss
3.36
815
812
3
G
O:
00
71
92
1
cohesin localization to chromatin
biol
ogic
al_p RB1
roce
ss
3.36
815
812
3
G
O:
00
72
26
2
metanephric glomerular mesangial cell
proliferation involved in metanephros
development
biol
ogic
al_p PDGFRB
roce
ss
3.36
815
812
3
G
O:
20
01
25
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
60
36
4
frontal suture morphogenesis
biol
ogic
al_p GLI3
roce
ss
3.36
815
812
3
fat cell proliferation
biol
ogic
al_p GATA2
roce
ss
3.36
815
812
3
metanephric mesenchyme morphogenesis
biol
ogic
al_p SMAD4
roce
ss
3.36
815
812
3
G
O:
00
10
91
5
regulation of very-low-density lipoprotein
particle clearance
biol
ogic
al_p LRPAP1
roce
ss
3.36
815
812
3
G
O:
negative regulation of fatty acid oxidation
biol
ogic
3.36
815
G
O:
00
70
34
1
G
O:
00
72
13
3
ACADVL
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
46
32
2
G
O:
00
71
46
2
G
O:
00
35
78
9
G
O:
00
10
91
6
G
O:
20
00
34
5
al_p
roce
ss
812
3
cellular response to water stimulus
biol
ogic
al_p PKD2
roce
ss
3.36
815
812
3
metanephric mesenchymal cell migration
biol
ogic
al_p PDGFRB
roce
ss
3.36
815
812
3
negative regulation of very-low-density
lipoprotein particle clearance
biol
ogic
al_p LRPAP1
roce
ss
3.36
815
812
3
regulation of hepatocyte proliferation
biol
ogic
al_p FBXW7
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
21
54
0
corpus callosum morphogenesis
biol
ogic
al_p PAFAH1B1
roce
ss
3.36
815
812
3
pyrimidine deoxyribonucleoside
triphosphate biosynthetic process
biol
ogic
al_p DTYMK
roce
ss
3.36
815
812
3
phenylalanyl-tRNA aminoacylation
biol
ogic
al_p FARSA
roce
ss
3.36
815
812
3
G
O:
00
48
75
7
pigment granule maturation
biol
ogic
al_p BLOC1S5
roce
ss
3.36
815
812
3
G
O:
hair follicle cell proliferation
biol
ogic
3.36
815
G
O:
00
09
21
2
G
O:
00
06
43
2
RUNX1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
71
33
5
G
O:
00
48
37
0
G
O:
00
30
22
3
G
O:
00
71
07
2
G
O:
20
00
98
7
al_p
roce
ss
812
3
lateral mesoderm formation
biol
ogic
al_p FGFR1
roce
ss
3.36
815
812
3
neutrophil differentiation
biol
ogic
al_p LEF1
roce
ss
3.36
815
812
3
negative regulation of phospholipid
biosynthetic process
biol
ogic
al_p LPCAT1
roce
ss
3.36
815
812
3
positive regulation of behavioral fear
response
biol
ogic
al_p MEF2A
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
18
11
9
peptidyl-cysteine S-nitrosylation
biol
ogic
al_p GAPDH
roce
ss
3.36
815
812
3
regulation of growth hormone receptor
signaling pathway
biol
ogic
al_p LEPROT
roce
ss
3.36
815
812
3
mitochondrial RNA processing
biol
ogic
al_p MTO1
roce
ss
3.36
815
812
3
G
O:
00
60
01
1
Sertoli cell proliferation
biol
ogic
al_p BCL2L2
roce
ss
3.36
815
812
3
G
O:
cadmium ion transmembrane transport
biol
ogic
3.36
815
G
O:
00
60
39
8
G
O:
00
00
96
3
SLC11A2
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
70
57
4
G
O:
00
19
32
3
G
O:
00
10
45
7
G
O:
00
01
83
5
G
O:
00
71
68
4
al_p
roce
ss
812
3
pentose catabolic process
biol
ogic
al_p RBKS
roce
ss
3.36
815
812
3
centriole-centriole cohesion
biol
ogic
al_p CEP135
roce
ss
3.36
815
812
3
blastocyst hatching
biol
ogic
al_p SMARCA4
roce
ss
3.36
815
812
3
organism emergence from protective
structure
biol
ogic
al_p SMARCA4
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
23
03
5
CD40 signaling pathway
biol
ogic
al_p SHARPIN
roce
ss
3.36
815
812
3
mRNA methylation
biol
ogic
al_p METTL3
roce
ss
3.36
815
812
3
negative regulation of neurotransmitter
secretion
biol
ogic
al_p NF1
roce
ss
3.36
815
812
3
G
O:
00
06
61
0
ribosomal protein import into nucleus
biol
ogic
al_p KPNB1
roce
ss
3.36
815
812
3
G
O:
regulation of blood vessel remodeling
biol
ogic
3.36
815
G
O:
00
80
00
9
G
O:
00
46
92
9
IL18
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
60
31
2
G
O:
00
02
36
1
G
O:
00
10
81
5
G
O:
00
38
02
8
G
O:
00
42
18
2
al_p
roce
ss
812
3
CD4-positive, CD25-positive, alpha-beta
regulatory T cell differentiation
biol
ogic
al_p NCOR1
roce
ss
3.36
815
812
3
bradykinin catabolic process
biol
ogic
al_p CTSH
roce
ss
3.36
815
812
3
insulin receptor signaling pathway via
phosphatidylinositol 3-kinase cascade
biol
ogic
al_p IGF2
roce
ss
3.36
815
812
3
ketone catabolic process
biol
ogic
al_p OXCT1
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
20
00
77
3
negative regulation of cellular senescence
biol
ogic
al_p CDK6
roce
ss
3.36
815
812
3
carbon catabolite activation of transcription
biol
ogic
al_p USF1
roce
ss
3.36
815
812
3
ganglioside catabolic process
biol
ogic
al_p HEXA
roce
ss
3.36
815
812
3
G
O:
00
30
32
0
cellular monovalent inorganic anion
homeostasis
biol
ogic
al_p CKB
roce
ss
3.36
815
812
3
G
O:
recognition of apoptotic cell
biol
ogic
3.36
815
G
O:
00
45
99
1
G
O:
00
06
68
9
PEAR1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
43
65
4
G
O:
00
48
34
2
G
O:
00
60
59
6
G
O:
00
35
30
8
G
O:
00
06
56
6
al_p
roce
ss
812
3
paraxial mesodermal cell differentiation
biol
ogic
al_p FOXC1
roce
ss
3.36
815
812
3
mammary placode formation
biol
ogic
al_p TBX2
roce
ss
3.36
815
812
3
negative regulation of protein
dephosphorylation
biol
ogic
al_p IGBP1
roce
ss
3.36
815
812
3
threonine metabolic process
biol
ogic
al_p THNSL2
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
16
08
0
synaptic vesicle targeting
biol
ogic
al_p
roce
ss
axon target recognition
biol
ogic
al_p BDNF
roce
ss
3.36
815
812
3
positive regulation of collateral sprouting
biol
ogic
al_p SEMA4D
roce
ss
3.36
815
812
3
G
O:
00
42
70
1
progesterone secretion
biol
ogic
al_p RUNX1
roce
ss
3.36
815
812
3
G
O:
cadmium ion transport
biol
ogic
3.36
815
G
O:
00
07
41
2
G
O:
00
48
67
2
3.36
815
5-Sep
812
3
SLC11A2
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
15
69
1
G
O:
00
43
30
8
G
O:
00
35
45
9
G
O:
00
02
05
1
G
O:
00
60
33
1
al_p
roce
ss
812
3
eosinophil degranulation
biol
ogic
al_p VAMP7
roce
ss
3.36
815
812
3
cargo loading into vesicle
biol
ogic
al_p TMED2
roce
ss
3.36
815
812
3
osteoblast fate commitment
biol
ogic
al_p RUNX2
roce
ss
3.36
815
812
3
negative regulation of response to
interferon-gamma
biol
ogic
al_p NR1H3
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
45
47
5
locomotor rhythm
biol
ogic
al_p PTEN
roce
ss
3.36
815
812
3
lacrimal gland development
biol
ogic
al_p FOXC1
roce
ss
3.36
815
812
3
dephosphorylation of RNA polymerase II Cterminal domain
biol
ogic
al_p RPRD1A
roce
ss
3.36
815
812
3
G
O:
00
06
54
3
glutamine catabolic process
biol
ogic
al_p GLS
roce
ss
3.36
815
812
3
G
O:
regulation of Ral protein signal transduction
biol
ogic
3.36
815
G
O:
00
32
80
8
G
O:
00
70
94
0
RALGAPA2
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
32
48
5
G
O:
00
72
01
4
G
O:
00
06
02
1
G
O:
00
36
01
8
G
O:
20
00
58
9
al_p
roce
ss
812
3
proximal tubule development
biol
ogic
al_p PKD1
roce
ss
3.36
815
812
3
inositol biosynthetic process
biol
ogic
al_p ISYNA1
roce
ss
3.36
815
812
3
cellular response to erythropoietin
biol
ogic
al_p EPOR
roce
ss
3.36
815
812
3
regulation of metanephric mesenchymal cell
migration
biol
ogic
al_p PDGFRB
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
48
34
3
paraxial mesodermal cell fate commitment
biol
ogic
al_p FOXC1
roce
ss
3.36
815
812
3
negative regulation of interleukin-2
biosynthetic process
biol
ogic
al_p CD276
roce
ss
3.36
815
812
3
telomere maintenance in response to DNA
damage
biol
ogic
al_p ACD
roce
ss
3.36
815
812
3
G
O:
00
02
44
7
eosinophil mediated immunity
biol
ogic
al_p VAMP7
roce
ss
3.36
815
812
3
G
O:
L-lysine catabolic process
biol
ogic
3.36
815
G
O:
00
45
08
5
G
O:
00
43
24
7
DLST
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
19
47
7
G
O:
00
90
39
4
G
O:
00
97
09
1
G
O:
00
71
45
9
G
O:
00
06
52
8
al_p
roce
ss
812
3
negative regulation of excitatory
postsynaptic membrane potential
biol
ogic
al_p PTEN
roce
ss
3.36
815
812
3
synaptic vesicle clustering
biol
ogic
al_p PTEN
roce
ss
3.36
815
812
3
protein localization to chromosome,
centromeric region
biol
ogic
al_p RB1
roce
ss
3.36
815
812
3
asparagine metabolic process
biol
ogic
al_p ASNS
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
60
36
8
regulation of Fc receptor mediated
stimulatory signaling pathway
biol
ogic
al_p CSK
roce
ss
3.36
815
812
3
positive regulation of cholesterol
homeostasis
biol
ogic
al_p NR1H3
roce
ss
3.36
815
812
3
regulation of cohesin localization to
chromatin
biol
ogic
al_p RB1
roce
ss
3.36
815
812
3
G
O:
00
55
08
3
monovalent inorganic anion homeostasis
biol
ogic
al_p CKB
roce
ss
3.36
815
812
3
G
O:
regulation of Ral GTPase activity
biol
ogic
3.36
815
G
O:
20
00
18
9
G
O:
00
71
92
2
RALGAPA2
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
00
32
31
5
G
O:
00
72
19
8
G
O:
00
46
44
0
G
O:
00
71
02
8
G
O:
00
30
64
4
al_p
roce
ss
812
3
mesenchymal cell proliferation involved in
ureter development
biol
ogic
al_p TBX18
roce
ss
3.36
815
812
3
L-lysine metabolic process
biol
ogic
al_p DLST
roce
ss
3.36
815
812
3
nuclear mRNA surveillance
biol
ogic
al_p XRN1
roce
ss
3.36
815
812
3
cellular chloride ion homeostasis
biol
ogic
al_p CKB
roce
ss
3.36
815
812
3
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
2.
6
5
E
0
1
G
O:
00
06
47
5
internal protein amino acid acetylation
biol
ogic
NOC2L,LEF1,DR1,PHF15,RPS6KA5,FLCN,ING4,MSL1,NAA10,SMARC
al_p
A4,KANSL3,GATA2
roce
ss
1.23
413
427
4
regulation of protein secretion
biol
ogic
CADM1,NLRP1,SYTL4,PAM,ADAM8,DNM1L,DISP1,RHBDF1,NR1H3,C
al_p
SF1R,C1QTNF3,RHBDF2
roce
ss
1.23
413
427
4
cellular protein complex assembly
biol
ogic
al_p
roce
ss
1.13
624
611
4
G
O:
00
43
29
7
apical junction assembly
biol
ogic
al_p F11R,PRKACA,PRKCH,TBCD,PARD6G
roce
ss
1.43
325
877
6
G
O:
CD4-positive, alpha-beta T cell activation
biol
ogic
1.43
325
G
O:
00
50
70
8
G
O:
00
43
62
3
TAZ,NUP98,HDAC6,ARPC4TTLL3,COG4,CAPZB,ACTR3,TTC19,DNM1L,FKBP1A,ARPC2,PXN,WA
SH4P,VILL,TBCD,COX14,ATPAF2,NCK2,ACTR2,SMAD4,CENPT,BCS1
L,TMED2,TWF1,TFAM,TGFBR3,SENP6,FMOD
BCL6,LEF1,RC3H1,NCOR1,STAT6
2.
6
6
E
0
1
2.
6
6
E
0
1
2.
6
7
E
0
1
2.
6
8
E
0
1
2.
6
00
35
71
0
G
O:
00
06
61
1
G
O:
00
43
96
6
G
O:
00
08
04
7
G
O:
00
06
60
5
al_p
roce
ss
877
6
protein export from nucleus
biol
ogic
al_p UHMK1,PRKACA,NUTF2,MDM2,PKD1
roce
ss
1.43
325
877
6
histone H3 acetylation
biol
ogic
al_p LEF1,DR1,PHF15,ING4,SMARCA4
roce
ss
1.43
325
877
6
enzyme activator activity
mol
ecul
ar_f
unct
ion
RAB3GAP2,RALGAPA2,NLRP1,ARHGEF12,BCL2L13,STARD13,DNAJ
C10,RANBP1,SIPA1L1,NOD1,TBC1D2B,TBC1D10B,TBC1D14,GIT2,ST
K4,MMP16,FAM13A,NF1,ACAP2,RGS3,ARHGAP9,IQGAP1,SRGAP2,T
BCD,ARHGAP29,SGSM3,UBA2,CTSH,TBC1D22A,ASAP1,RGS2,DBF4,I
GF2,BNIP2
1.12
007
301
7
protein targeting
biol
ogic
al_p
roce
ss
BCL6,NUP98,RBPMS,KPNA6,VAMP7,HPS4,TIMM23,SRP9,DDX58,RPL
27,NF1,RPL9,PKD2,LMNA,GCC2,RPL24,RPL37A,KPNB1,PPP1R10,CA
CNB1,TIMM50,OS9,SMAD4,GRPEL2,C1QTNF3,RPL4,FLNA,GLI3,TME
D2,SLC25A6,MDFI,RPLP0,KIF13B,PDIA3,LONP2,ATG3,SPCS3,PKD1,K
PNA1,UBR5
1.10
885
864
1
8
E
0
1
2.
6
8
E
0
1
2.
6
8
E
0
1
2.
6
8
E
0
1
2.
6
8
E
0
1
G
O:
00
05
26
2
calcium channel activity
mol
ecul
ar_f
unct
ion
adaptive immune response
biol
ogic
CADM1,BCL6,LEF1,PTPN6,RC3H1,C2,RNF8,RNF168,IL18,C1R,MEF2A
al_p
,PTPRC,SWAP70,CTSH,C3,C1S,ERCC1,STAT6
roce
ss
1.17
722
031
5
carbon-oxygen lyase activity
mol
ecul
ar_f
unct
ion
1.37
356
910
3
G
O:
00
30
66
0
Golgi-associated vesicle membrane
cell
ular
_co CLTCL1,CLTB,TMED3,TMED2
mpo
nent
1.51
279
219
2
G
O:
organophosphate biosynthetic process
biol
ogic
1.10
185
G
O:
00
02
25
0
G
O:
00
16
83
5
CAMK2D,TPCN2,SGK1,FKBP1A,PKD2,PHPT1,CACNB1,TMEM66,TRP
M7,CACNB3,CACNA2D1,CACNA2D4,PKD1
PTS,GMDS,HSD17B4,CA5B,THNSL2,ENO4
RAF1,TAZ,CMPK2,PLD1,GPAA1,PGS1,FDPS,PIGS,PNPO,PIGG,PDXK,
PIGN,NADSYN1,ADCY4,CHKB,NADK,IDI1,GPAT2,NF1,NPR1,ADSL,IS
1.21
936
053
5
2.
6
9
E
0
1
2.
6
9
E
0
1
2.
7
0
E
0
1
2.
7
0
E
0
1
2.
7
00
90
40
7
G
O:
00
16
33
1
G
O:
00
00
08
6
G
O:
00
44
44
1
G
O:
00
46
63
4
al_p YNA1,GPCPD1,GARS,PLD6,FLCN,GMDS,MTMR14,PTEN,IMPDH1,DT
roce YMK,MBOAT2,ATP5A1,AK5,LPCAT1,GSK3A,PCYT1A,PIGO,GPHN,NT
ss
RK1,UCK1,ALG9,PANK3,PLA2G16
098
5
morphogenesis of embryonic epithelium
biol
ogic
FZD6,NPHP3,PAX8,VASP,JAG2,TBX18,STK4,ALDH1A3,IFT172,TCTN1
al_p
,TGFB1I1,TMED2,SETD2
roce
ss
1.21
627
932
2
G2/M transition of mitotic cell cycle
biol
ogic
CDK14,CEP135,USP47,PRKACA,ANAPC4,PLK1,SDCCAG8,NUMA1,PA
al_p
FAH1B1,CDK5RAP2,DYNC1I2,CSNK1E,CLASP1
roce
ss
1.21
627
932
2
cilium part
cell
ular
TTLL3,BBS1,PKD2,TCTN1,CLTB,WDR35,EVC,DZIP1,CC2D2A,TMEM2
_co
37,SEPT2
mpo
nent
1.24
134
359
3
regulation of alpha-beta T cell activation
biol
ogic
al_p BCL6,RC3H1,IL18,PTPRC,GLI3,TNFRSF14
roce
ss
1.37
009
822
0
E
0
1
2.
7
2
E
0
1
2.
7
2
E
0
1
2.
7
2
E
0
1
2.
7
2
E
0
1
G
O:
00
02
50
4
antigen processing and presentation of
peptide or polysaccharide antigen via MHC
class II
biol
ogic
HLA-DPB1,DYNC1I1,HLA-DQA1,HLAal_p
DMB,SEC31A,LGMN,KLC1,CANX,DYNC1I2
roce
ss
1.27
635
465
7
regulation of actin filament polymerization
biol
ogic
ARPC4al_p
TTLL3,CAPZB,ACTR3,ARPC2,WASH4P,VILL,NCK2,ACTR2,TWF1
roce
ss
1.27
635
465
7
skeletal system development
biol
ogic
al_p
roce
ss
RAI1,COL9A1,COL2A1,BMP8A,GLG1,MEPE,JAG2,FGFR1,COL12A1,T
HBS3,ZEB1,NIPBL,HEXA,RUNX2,MEF2A,DYM,PTPRC,EVC,ACD,SEM
A4D,GLI3,EXT1,MDFI,PDGFRB,RUNX1,SETD2,COL13A1,IGF2,SMAD9,
ZBTB16,PKD1,FOXC1,ACAN
1.11
989
136
6
G
O:
00
43
12
2
regulation of I-kappaB kinase/NF-kappaB
cascade
biol
ogic
NOD1,PPP5C,SHISA5,MIB2,TAB2,SHARPIN,FKBP1A,PLEKHG5,PLK2,I
al_p
KBKB,LTBR,C1QTNF3,APOL3,FLNA,TNFRSF10B,PDPK1,CC2D1A
roce
ss
1.18
059
150
7
G
O:
phospholipase activity
mol
ecul
1.18
740
G
O:
00
30
83
3
G
O:
00
01
50
1
PLCD1,PLD1,SMPD4,PRKACA,PLCB4,FGFR1,ADCY4,CREB1,ANXA5,
BICD1,PLD6,RGS2,PDGFRB,PDIA3,NTRK1,PLA2G16
2.
7
2
E
0
1
2.
7
2
E
0
1
2.
7
2
E
0
1
2.
7
3
E
0
1
2.
7
00
04
62
0
G
O:
00
31
14
5
G
O:
00
10
90
6
G
O:
00
60
19
3
G
O:
00
22
60
2
ar_f
unct
ion
772
3
anaphase-promoting complex-dependent
proteasomal ubiquitin-dependent protein
catabolic process
biol
ogic
al_p PSMB10,PSMB9,ANAPC4,PLK1,PTEN,PSMC6,PSMC4,PSMA1
roce
ss
1.29
856
698
7
regulation of glucose metabolic process
biol
ogic
al_p GRB10,NCOR1,SMEK1,PHKG2,C1QTNF3,ARNT,GSK3A,IGF2
roce
ss
1.29
856
698
7
positive regulation of lipase activity
biol
ogic
al_p PRKACA,FGFR1,ADCY4,CREB1,NR1H3,PDGFRB,NTRK1,LMF1
roce
ss
1.29
856
698
7
ovulation cycle process
biol
ogic
al_p EIF2B4,ADAMTS1,PAM,CASP2,RUNX1,NCOR2,ROBO2,FOXC1
roce
ss
1.29
856
698
7
3
E
0
1
2.
7
3
E
0
1
2.
7
3
E
0
1
2.
7
3
E
0
1
2.
7
3
E
0
1
G
O:
20
01
14
1
regulation of RNA biosynthetic process
G
O:
positive regulation of cell migration
FZD6,PBX2,KANK2,RAI1,SIRT2,MYNN,NOC2L,ZNF131,RSC1A1,SFSW
AP,CDK13,SIN3B,CBX5,SUPT5H,SUPT20H,BCL6,FUBP1,ZNF783,TBX
2,MMS19,CUX1,EED,SMAD7,MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,
LEF1,PAX8,SUPT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PAM,USP
47,ADAM8,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,ST
AT2,PLK1,ZNF446,PTGES2,ZNF621,HDGF,CCNL1,CHD6,ZC3H12A,FA
M58A,TBX18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZN
F710,WAC,ZNF142,FUBP3,ZNF540,FGFR1,HSF4,PAF1,TAB2,SGK1,D
PF2,MDM2,PRKCH,PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,C
REB1,FLII,RPRD1A,DDX58,CCNL2,PTPRK,ZEB1,IFITM3,ASCC2,RGM
B,EBF1,MED28,ZNF3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,RXRB,LM
NA,MITF,RB1,PRMT5,MZF1,ZFPM2,TP53BP1,ZNF865,SENP2,SUB1,C
biol
HMP1A,PDE8A,ZNF558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,USP7,
ogic
FLCN,ZNF605,ZNF410,SAP30BP,VPS72,PTEN,RUNX2,FBXW7,SMAR
al_p
CD3,IKBKB,RQCD1,RFX7,NCOR1,MEF2A,SETD8,PIAS2,MAPK8,MYCB
roce
P2,USP15,DDX41,PBX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5R
ss
AP2,UBP1,WDR61,EBF4,ZNF148,ZNF76,SP110,NCK2,TCF4,IKZF5,HM
GN2,SEMA4D,SSBP2,ERC1,NFYC,SRSF10,SS18,RCOR3,SMAD4,CHU
RC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,ZNF44,CREBZF,ING4,ZNF687,
NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,MAPK12,CCDC59,DCAF6,E
NG,SIRT7,ZSCAN5A,TCF12,ARNT,ZNF692,PHF1,STK36,WWP1,PHF12
,MED6,MDFI,ZNF554,HINFP,NCBP2,MLX,TGS1,CDK11A,GLIS3,ELP6,
BDP1,RUNX1,SMARCA4,NAA16,LRPPRC,RAD54L2,ZNF518B,ZNF90,Z
NF638,PER3,ZNF383,NCOR2,SETD2,IGF2,PTGIS,ATXN3,PHF21A,PD
CD4,SOX13,CHD2,STAT6,ZNF138,ZNF705A,NTRK1,TFAM,BRWD1,SM
AD9,TGFBR3,ZBTB16,BAZ2A,RRP8,PHF19,LMCD1,PKD1,PDPK1,TSG
101,USF1,FOXC1,CDK5RAP3,EYA2,SMARCAD1,CC2D1A,GATA2
biol IGF1R,LAMB1,HDAC6,LEF1,ADAM8,AAMP,PPM1F,COL18A1,NRP1,MY
ogic LK,PTPRC,RARRES2,SEMA6A,CTSH,SEMA4D,CSF1R,SUN2,NOX4,P
1.03
507
728
8
2.
7
4
E
0
1
1.16
143
2.
7
00
30
33
5
G
O:
00
30
09
8
G
O:
00
71
90
2
G
O:
00
05
21
7
G
O:
00
02
29
2
al_p DGFRB,ELP6
roce
ss
383
6
lymphocyte differentiation
biol
ogic SART1,BCL6,PTPN22,IL15RA,LEF1,ADAM8,MINK1,PTPN6,JAG2,RC3H
al_p 1,POLM,ZEB1,RUNX2,NCOR1,PTPRC,CDK6,GLI3,LGALS8,STAT6,NT
roce RK1
ss
1.16
143
383
6
positive regulation of protein
serine/threonine kinase activity
biol
ogic IGF1R,RAF1,ZFP91,ADAM8,NOD1,STK4,FGFR1,TAB2,PKD2,MAPK8IP
al_p 3,PXN,CSK,PTPRC,PAK1,CSF1R,NOX4,MDFI,PDGFRB,CARD14,IGF2,
roce NTRK1,TNFRSF10B,PKD1
ss
1.14
766
869
4
intracellular ligand-gated ion channel
activity
mol
ecul
ar_f
unct
ion
1.50
075
142
8
T cell differentiation involved in immune
response
biol
ogic
al_p BCL6,LEF1,RC3H1,STAT6
roce
ss
CAMK2D,TPCN2,FKBP1A,PKD2
1.49
695
916
6
5
E
0
1
2.
7
5
E
0
1
2.
7
5
E
0
1
2.
7
5
E
0
1
2.
7
7
E
0
1
G
O:
00
02
76
3
positive regulation of myeloid leukocyte
differentiation
biol
ogic
al_p LEF1,RB1,RUNX1,ACIN1
roce
ss
1.49
695
916
6
positive regulation of locomotion
biol
ogic IGF1R,LAMB1,HDAC6,LEF1,ADAM8,AAMP,PPM1F,COL18A1,NRP1,PH
al_p PT1,MYLK,PTPRC,RARRES2,SEMA6A,CTSH,SEMA4D,CSF1R,SUN2,
roce NOX4,PDGFRB,ELP6
ss
1.15
479
707
1
signal transduction in response to DNA
damage
biol
ogic
USP10,PSMB10,PSMB9,MDM2,CASP2,SETD8,PSMC6,PSMC4,ING4,P
al_p
SMA1,SPRED1
roce
ss
1.23
499
131
2
G
O:
00
46
96
5
retinoid X receptor binding
mol
ecul
ar_f
unct
ion
NCOR1,NCOR2
1.92
953
755
G
O:
solute:hydrogen symporter activity
mol
ecul
SLC11A2,SLC35A4
1.92
953
G
O:
00
40
01
7
G
O:
00
42
77
0
2.
7
7
E
0
1
2.
7
7
E
0
1
2.
7
7
E
0
1
2.
7
8
E
0
1
2.
7
00
15
29
5
G
O:
00
05
16
1
G
O:
00
04
83
5
G
O:
00
16
86
3
G
O:
00
31
09
8
ar_f
unct
ion
755
platelet-derived growth factor receptor
binding
mol
ecul
ar_f
unct
ion
ITGA5,PDGFRB
1.92
953
755
tubulin-tyrosine ligase activity
mol
ecul
ar_f
unct
ion
TTLL3,TTLL11
1.92
953
755
intramolecular oxidoreductase activity,
transposing C=C bonds
mol
ecul
ar_f
unct
ion
IDI1,EBPL
1.92
953
755
stress-activated protein kinase signaling
cascade
biol
ogic IGF1R,MINK1,IGBP1,NOD1,TAB2,CREB1,RPS6KA5,MAPK8IP3,PAFAH
al_p 1B1,LTBR,NCOR1,MEF2A,MAPK8,MAP4K4,PAK1,MDFI,FGF14,PDCD4
roce ,DUSP6
ss
1.16
354
553
4
8
E
0
1
2.
7
8
E
0
1
2.
7
8
E
0
1
2.
7
8
E
0
1
2.
7
9
E
0
1
G
O:
20
00
05
8
regulation of protein ubiquitination involved
in ubiquitin-dependent protein catabolic
process
biol
ogic
al_p PTEN,FBXW7
roce
ss
1.92
466
178
5
coronary vasculature development
biol
ogic
al_p PDGFRB,SETD2
roce
ss
1.92
466
178
5
regulation of hair cycle
biol
ogic
al_p NIPBL,SMAD4
roce
ss
1.92
466
178
5
G
O:
00
45
64
9
regulation of macrophage differentiation
biol
ogic
al_p RB1,GATA2
roce
ss
1.92
466
178
5
G
O:
regulation of protein homooligomerization
biol
ogic
1.92
466
G
O:
00
60
97
6
G
O:
00
42
63
4
CRBN,BCL2L11
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
00
32
46
2
G
O:
00
51
45
7
G
O:
00
02
70
4
G
O:
00
71
87
5
G
O:
00
32
29
1
al_p
roce
ss
178
5
maintenance of protein location in nucleus
biol
ogic
al_p SYNE1,SUN2
roce
ss
1.92
466
178
5
negative regulation of leukocyte mediated
immunity
biol
ogic
al_p PTPN6,PTPRC
roce
ss
1.92
466
178
5
adrenergic receptor signaling pathway
biol
ogic
al_p RGS2,GSK3A
roce
ss
1.92
466
178
5
axon ensheathment in central nervous
system
biol
ogic
al_p PTEN,TENM4
roce
ss
1.92
466
178
5
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
G
O:
00
06
74
0
NADPH regeneration
biol
ogic
al_p H6PD,IDH1
roce
ss
1.92
466
178
5
ventricular cardiac muscle cell development
biol
ogic
al_p LMNA,MEF2A
roce
ss
1.92
466
178
5
negative regulation of peptidyl-serine
phosphorylation
biol
ogic
al_p SMAD7,PPM1F
roce
ss
1.92
466
178
5
G
O:
00
70
29
3
renal absorption
biol
ogic
al_p SGK1,HBB
roce
ss
1.92
466
178
5
G
O:
dermatan sulfate proteoglycan metabolic
process
biol
ogic
1.92
466
G
O:
00
55
01
5
G
O:
00
33
13
7
UST,B3GAT3
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
00
50
65
5
G
O:
00
10
82
9
G
O:
00
45
06
3
G
O:
00
02
71
4
G
O:
00
09
21
9
al_p
roce
ss
178
5
negative regulation of glucose transport
biol
ogic
al_p GRB10,GSK3A
roce
ss
1.92
466
178
5
T-helper 1 cell differentiation
biol
ogic
al_p LEF1,STAT6
roce
ss
1.92
466
178
5
positive regulation of B cell mediated
immunity
biol
ogic
al_p PTPRC,C3
roce
ss
1.92
466
178
5
pyrimidine deoxyribonucleotide metabolic
process
biol
ogic
al_p CMPK2,DTYMK
roce
ss
1.92
466
178
5
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
G
O:
00
22
01
0
central nervous system myelination
biol
ogic
al_p PTEN,TENM4
roce
ss
1.92
466
178
5
arginine metabolic process
biol
ogic
al_p DDAH1,DDAH2
roce
ss
1.92
466
178
5
regulation of fibrinolysis
biol
ogic
al_p FAP,USF1
roce
ss
1.92
466
178
5
G
O:
00
50
68
6
negative regulation of mRNA processing
biol
ogic
al_p SFSWAP,SRSF10
roce
ss
1.92
466
178
5
G
O:
nephron tubule epithelial cell differentiation
biol
ogic
1.92
466
G
O:
00
06
52
5
G
O:
00
51
91
7
PAX8,MEF2A
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
00
72
16
0
G
O:
00
45
91
1
G
O:
00
08
35
4
G
O:
00
71
04
4
G
O:
00
35
30
6
al_p
roce
ss
178
5
positive regulation of DNA recombination
biol
ogic
al_p PTPRC,STAT6
roce
ss
1.92
466
178
5
germ cell migration
biol
ogic
al_p PPAP2A,FOXC1
roce
ss
1.92
466
178
5
histone mRNA catabolic process
biol
ogic
al_p XRN1,UPF1
roce
ss
1.92
466
178
5
positive regulation of dephosphorylation
biol
ogic
al_p IGBP1,SYMPK
roce
ss
1.92
466
178
5
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
G
O:
00
30
85
2
regulation of granulocyte differentiation
biol
ogic
al_p LEF1,RUNX1
roce
ss
1.92
466
178
5
regulation of telomere maintenance
biol
ogic
al_p ACD,ERCC1
roce
ss
1.92
466
178
5
dermatan sulfate proteoglycan biosynthetic
process
biol
ogic
al_p UST,B3GAT3
roce
ss
1.92
466
178
5
G
O:
00
60
56
1
apoptotic process involved in
morphogenesis
biol
ogic
al_p LEF1,PAX8
roce
ss
1.92
466
178
5
G
O:
negative regulation of lymphocyte mediated
immunity
biol
ogic
1.92
466
G
O:
00
32
20
4
G
O:
00
50
65
1
PTPN6,PTPRC
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
00
02
70
7
G
O:
00
72
18
9
G
O:
00
71
10
8
G
O:
00
06
95
7
G
O:
00
42
14
9
al_p
roce
ss
178
5
ureter development
biol
ogic
al_p NPHP3,TBX18
roce
ss
1.92
466
178
5
protein K48-linked deubiquitination
biol
ogic
al_p USP20,USP33
roce
ss
1.92
466
178
5
complement activation, alternative pathway
biol
ogic
al_p CFB,C3
roce
ss
1.92
466
178
5
cellular response to glucose starvation
biol
ogic
al_p ASNS,RRP8
roce
ss
1.92
466
178
5
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
G
O:
00
10
71
9
G
O:
00
02
89
1
G
O:
00
51
71
6
negative regulation of epithelial to
mesenchymal transition
biol
ogic
al_p SMAD7,TGFBR3
roce
ss
1.92
466
178
5
positive regulation of immunoglobulin
mediated immune response
biol
ogic
al_p PTPRC,C3
roce
ss
1.92
466
178
5
cellular response to stimulus
FZD6,CDK14,USP10,KANK2,ACADVL,EIF2B4,PSMB10,IGF1R,NPHP3,
TNRC6A,EPHX2,RALGAPA2,BTN3A1,NOC2L,RAF1,NLRP1,GP1BB,F1
1R,CPE,PLCD1,SART1,COL2A1,RAB34,SUPT5H,HLADPB1,BCL6,CMPK2,TBX2,PTPN22,MMS19,ZFP91,CNTF,EEF2K,PLD1,
VAPB,NUP98,SMPD4,SMAD7,MCF2L,HDAC6,GLG1,ARHGEF12,ATP6
V1D,VRK2,HGS,DERL2,IL15RA,LANCL2,CD72,DGKA,PNKP,LEF1,PAX
biol
8,HLAogic
C,PSMB9,ITGA9,ARHGEF25,ADAMTS1,RGL4,BCL2L11,RBPMS,XYLT1
al_p
,STARD13,XBP1,NISCH,HLAroce
DQA1,RAD23A,APITD1,USP47,ADAM8,DNAJC10,RAB35,XAF1,RANBP
ss
1,SIPA1L1,KRIT1,MINK1,RHOF,PTPN6,VASP,CSNK2A1,IGBP1,NOD1,
PRKACA,STAT2,DHX9,PLK1,APLNR,PDE7B,ASNS,TBC1D2B,COL16A
1,JAG2,DNM1L,UPF1,HDGF,RC3H1,PPP5C,NPC1,SHISA5,RHOBTB1,
HERC2,ZC3H12A,NUP210,TBC1D10B,SEPT4,MIB2,POLM,SLC11A2,R
AB24,ATG4B,IL13RA1,TBX18,BCLAF1,CAMK2D,PLCB4,GIGYF2,TBC1
D14,TNK2,USP20,GIT2,WAC,STK4,FGFR1,RAB18,DISP1,PMS1,ADCY
1.02
259
070
2
2.
7
9
E
0
1
2.
7
9
E
0
1
2.
7
9
E
0
1
4,PDE4D,GSDMD,PAF1,TAB2,SGK1,PLEKHG4,SHARPIN,DPF2,RNF8,
KIAA0586,CYP2R1,SEC31A,MDM2,RHBDD1,FKBP1A,ZFYVE26,PRKC
H,PPM1F,YY1,FAM13A,INO80,PFDN5,CREB1,NPTN,RALGPS2,TNFRS
F25,PLEKHG5,DDX58,LCP2,PTPRK,SNX13,RHBDF1,MAGI1,NF1,ZEB1
,EIF4B,CRIP1,IFITM3,LGALS3BP,ATG12,SPSB3,RGMB,RTKN,NPR1,R
PS6KA5,G3BP1,NIPBL,RAB31,ALKBH3,CAPN10,PKD2,CASP2,SLC12A
6,RXRB,LMNA,MITF,ITGA3,RB1,LTBP4,MAPK8IP3,GNAI1,USP3,TP53B
P1,BLOC1S5,RNF168,PAFAH1B1,SENP2,IL18,MTCH1,TPP1,PWP2,CH
MP1A,PDE8A,AACS,STK38L,EPN2,ACAP2,ANXA5,SH3BP5,MUM1,US
P33,BICD1,RGS3,NR1H3,CYTH2,GRB10,PLK2,USP7,FLCN,NRP1,CUL
4A,TENC1,FMO2,GMDS,IGFBP6,ARHGAP9,STX2,PTEN,FYN,SRPK1,R
UNX2,IQGAP1,FBXW7,PHPT1,HERPUD1,IFT172,IKBKB,RQCD1,SNX1
7,PXN,ADAMTS18,KPNB1,SRGAP2,LTBR,PTPRF,NCOR1,MEF2A,OXC
T1,TNS1,FECH,LIFR,SETD8,ITGB5,TCTN1,PIAS2,FIBP,MAPK8,SH3BP
2,CLTCL1,MYLK,USP15,DDX41,HLAF,RAB8A,TRIM28,DENND4C,MAP4K4,CSK,PTPRS,PTPRC,PSMC6,RN
F146,CDK6,RARRES2,WDR61,NUP37,APPL2,FLOT1,PSMC4,ARHGAP
29,SGSM3,AAK1,SP110,IL10RA,PAK1,EVC,NCK2,LEPROT,LEPR,RAB
10,RHEB,SEMA6A,CTSH,ZSWIM7,ACD,SEMA4D,GNB3,CSF1R,ATP6V
0A1,ERC1,TIMM50,OS9,DGKZ,C3,ALDH3B1,SS18,SMAD4,TBC1D22A,
C1QTNF3,TGFB1I1,DDAH1,INO80E,DTYMK,ASB8,GOLPH3,TANK,ING
4,CDC14B,NR2C2,LRPAP1,APOL3,FLNA,RAB5A,IRF9,GLI3,SDCBP2,M
APK12,RASGRF2,EPS15L1,AK5,EPN1,ENG,ARNT,NOX4,EXT1,GAPD
H,ERCC1,PHF1,BICC1,NRBP2,STK36,WWP1,ARHGEF7,DEF8,PDIA5,
ASAP1,UNC5B,MDFI,NUP85,PPFIA1,PTPRD,ITGA5,RGS2,HINFP,STA
M2,PDGFRB,RAD51B,EPOR,CARD14,CC2D2A,DIABLO,FARP1,TNFRS
F14,RAP1B,RUNX1,MKNK2,SMARCA4,YIF1A,SNX27,KIF13B,CRCP,PE
R3,TLN1,FGF14,CD164,DOCK8,ADRBK2,GSK3A,ANKRD6,ITGA11,NL
GN2,POLG,POLR2J3,NCOR2,PPAP2A,PDIA3,IGF2,PTGIS,MYO1E,ATX
N3,AMFR,MOB1A,PDCD4,ARL15,SNX14,RGL2,RABL3,CRIPAK,PSMA1
,STAT6,PSD3,ROBO2,CSNK1E,CACNB3,CLIC4,NSMCE4A,BNIP2,NTR
K1,SHPRH,SPRED1,TNFRSF10B,MPZL1,ATG3,SMAD9,HBB,DUSP6,T
GFBR3,TMEM237,RRP8,LMCD1,SEPT2,PKD1,PDPK1,USF1,FOXC1,K
PNA1,DDAH2,STK24,SSH1,RAPGEF6,FMOD,C2CD3,UBR5,FASTK,EY
A2,SMARCAD1,WNK1,CC2D1A,TENM4,ZC3H15,PGRMC2,GATA2
G
O:
00
16
05
5
G
O:
00
60
48
5
G
O:
19
01
65
2
G
O:
00
43
01
4
Wnt receptor signaling pathway
biol
ogic FZD6,CDK14,NPHP3,LEF1,CSNK2A1,TBX18,STK4,PAF1,PFDN5,G3BP
al_p 1,MITF,SENP2,GRB10,PTEN,RNF146,WDR61,TGFB1I1,RAB5A,GLI3,BI
roce CC1,MDFI,GSK3A,ANKRD6,CSNK1E,TMEM237,UBR5
ss
1.13
361
956
3
mesenchyme development
biol
ogic
TBX2,SMAD7,LEF1,FGFR1,PKD2,ADAM15,MEF2A,TRIM28,SMAD4,TG
al_p
FB1I1,FLNA,ENG,PDGFRB,TGFBR3,FOXC1
roce
ss
1.18
876
169
1
response to peptide
biol
ogic
al_p
roce
ss
EIF2B4,IGF1R,RAF1,NLRP1,EEF2K,ATP6V1D,PTPN6,PRKACA,FGFR1
,ADCY4,MDM2,EIF4B,RAB31,CAPN10,GNAI1,IL18,GRB10,FYN,PXN,D
ENND4C,CSK,PAK1,LEPROT,RAB10,RHEB,GNB3,ATP6V0A1,GSK3A,I
GF2,PDPK1,USF1
1.11
970
940
3
alpha-tubulin binding
mol
ecul
ar_f
unct
ion
HDAC6,INO80,WASH4P
1.62
081
154
2
2.
8
0
E
0
1
2.
8
0
E
0
1
2.
8
1
E
0
1
2.
8
1
E
0
1
G
O:
00
04
53
2
G
O:
00
05
24
6
G
O:
00
05
79
8
G
O:
00
51
78
3
G
O:
00
32
exoribonuclease activity
mol
ecul
ar_f
unct
ion
calcium channel regulator activity
mol
ecul
ar_f
unct
ion
Golgi-associated vesicle
cell
ular
_co CLTCL1,CLTB,GOPC,TMED3,TMED2,SCFD1
mpo
nent
1.35
419
301
regulation of nuclear division
biol
ogic
al_p CDK13,RANBP1,ANAPC4,PLK1,RB1,PRMT5,PTEN,PDGFRB,IGF2
roce
ss
1.26
305
929
6
regulation of microtubule-based process
biol
ogic HDAC6,RANBP1,IGBP1,PLK2,CDK5RAP2,TBCD,MEMO1,SENP6,CLAS
al_p P1
roce
1.26
305
929
6
DIS3L,PAN2,PARN
1.62
081
154
2
SGK1,FKBP1A,PHPT1
1.62
081
154
2
2.
8
1
E
0
1
2.
8
1
E
0
1
2.
8
1
E
0
1
2.
8
2
E
0
1
2.
8
2
E
88
6
G
O:
00
07
08
8
G
O:
00
51
69
3
G
O:
00
19
67
4
G
O:
00
46
00
6
ss
regulation of mitosis
biol
ogic
al_p CDK13,RANBP1,ANAPC4,PLK1,RB1,PRMT5,PTEN,PDGFRB,IGF2
roce
ss
1.26
305
929
6
actin filament capping
biol
ogic
al_p CAPZB,VILL,TWF1
roce
ss
1.61
671
589
9
NAD metabolic process
biol
ogic
al_p NADSYN1,NADK,IDH3B
roce
ss
1.61
671
589
9
regulation of activated T cell proliferation
biol
ogic
al_p RC3H1,IL18,IGF2
roce
ss
1.61
671
589
9
0
1
2.
8
2
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
G
O:
00
40
03
6
regulation of fibroblast growth factor
receptor signaling pathway
biol
ogic
al_p NPTN,RUNX2,DUSP6
roce
ss
1.61
671
589
9
NIK/NF-kappaB cascade
biol
ogic
al_p ZFP91,CARD14,TNFRSF10B
roce
ss
1.61
671
589
9
mesodermal cell differentiation
biol
ogic
al_p FGFR1,FOXC1,EYA2
roce
ss
1.61
671
589
9
G
O:
00
08
29
9
isoprenoid biosynthetic process
biol
ogic
al_p FDPS,IDI1,ALDH1A3
roce
ss
1.61
671
589
9
G
O:
00
43
regulation of DNA damage response, signal
transduction by p53 class mediator
biol
ogic
MDM2,SETD8,SPRED1
al_p
roce
1.61
671
589
9
G
O:
00
38
06
1
G
O:
00
48
33
3
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
51
6
G
O:
00
44
05
8
G
O:
00
36
15
1
G
O:
00
46
83
5
G
O:
00
31
95
2
ss
regulation of digestive system process
biol
ogic
al_p SGK1,NR1H3,WNK1
roce
ss
1.61
671
589
9
phosphatidylcholine acyl-chain remodeling
biol
ogic
al_p MBOAT2,LPCAT1,PLA2G16
roce
ss
1.61
671
589
9
carbohydrate phosphorylation
biol
ogic
al_p GALK2,NAGK,RBKS
roce
ss
1.61
671
589
9
regulation of protein autophosphorylation
biol
ogic
al_p EEF2K,PTPRC,ENG
roce
ss
1.61
671
589
9
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
G
O:
19
01
79
6
regulation of signal transduction by p53
class mediator
biol
ogic
al_p MDM2,SETD8,SPRED1
roce
ss
1.61
671
589
9
protein localization to chromosome
biol
ogic
al_p PLK1,RB1,ACD
roce
ss
1.61
671
589
9
monocyte differentiation
biol
ogic
al_p MEF2A,CSF1R,ACIN1
roce
ss
1.61
671
589
9
G
O:
00
00
03
8
very long-chain fatty acid metabolic process
biol
ogic
al_p ACAA1,HSD17B4,ELOVL1
roce
ss
1.61
671
589
9
G
O:
00
30
heparan sulfate proteoglycan metabolic
process
biol
ogic
XYLT1,EXT1,B3GAT3
al_p
roce
1.61
671
589
9
G
O:
00
34
50
2
G
O:
00
30
22
4
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
20
1
G
O:
00
18
20
8
G
O:
00
35
27
2
G
O:
00
51
14
5
G
O:
00
43
24
2
ss
peptidyl-proline modification
biol
ogic
al_p PPIL2,FKBP1A,FKBP10,NTMT1,P4HB
roce
ss
1.40
339
921
8
exocrine system development
biol
ogic
al_p IGF1R,XBP1,FGFR1,NRP1,FOXC1
roce
ss
1.40
339
921
8
smooth muscle cell differentiation
biol
ogic
al_p TBX18,ZEB1,MED28,MEF2A,SMARCA4
roce
ss
1.40
339
921
8
negative regulation of protein complex
disassembly
biol
ogic
al_p HDAC6,CAPZB,VILL,TWF1,CLASP1
roce
ss
1.40
339
921
8
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
3
E
0
1
G
O:
00
32
01
2
regulation of ARF protein signal
transduction
biol
ogic
al_p GIT2,ACAP2,CYTH2,ASAP1,PSD3
roce
ss
1.40
339
921
8
actin polymerization or depolymerization
biol
ogic ARPC4al_p TTLL3,CAPZB,ACTR3,VASP,SSH2,ARPC2,WASH4P,VILL,NCK2,ACTR
roce 2,TWF1,SSH1
ss
1.21
557
586
4
vesicle-mediated transport
SEPT5,RAB34,CUX1,SYTL4,COG4,AP3S2,CD9,NPC1,VAMP7,BBS1,T
NK2,USP20,VTI1A,RAB18,SEC31A,SNAP23,SFT2D2,MCFD2,AP4B1,R
biol EPS1,LGALS3BP,RAB31,MAPK8IP3,GNAI1,STX16,BLOC1S5,TXNDC5,
ogic SYTL2,CHMP1A,EPN2,USP33,BICD1,GCC2,NR1H3,CYTH2,NRP1,STX
al_p 2,SNX17,WASH4P,CLTCL1,RAB8A,CSK,STX18,CLTB,AAK1,GOPC,PA
roce K1,RAB10,PEAR1,VPS45,ERC1,C3,LRPAP1,FLNA,RAB5A,TMED2,EPS
ss
15L1,EPN1,SCFD1,VTI1B,VAMP4,TRAPPC12,VPS51,CANX,YIF1A,CR
CP,TLN1,ADRBK2,MYO1E,PSD3,LMF1,SEC31B,PDPK1,LRP3,CD63,S
CAMP1,GATA2
G
O:
00
02
06
4
epithelial cell development
biol
ogic
al_p PAX8,XBP1,PDE4D,COL18A1,IQGAP1,ENG,MYO1E,CLIC4
roce
ss
1.28
310
785
7
G
O:
cellular polysaccharide metabolic process
biol
ogic
1.28
310
G
O:
00
08
15
4
G
O:
00
16
19
2
GRB10,PHKG2,EXT1,GAA,GSK3A,IGF2,PGM2,PHKG1
1.06
837
559
4
2.
8
3
E
0
1
2.
8
3
E
0
1
2.
8
4
E
0
1
2.
8
4
E
0
1
2.
8
00
44
26
4
G
O:
00
09
88
0
G
O:
00
51
35
2
G
O:
00
51
44
4
G
O:
00
45
86
2
al_p
roce
ss
785
7
embryonic pattern specification
biol
ogic
al_p DISP1,PLD6,SMAD4,TMED2,ZBTB16,C2CD3
roce
ss
1.34
726
324
9
negative regulation of ligase activity
biol
ogic
al_p PSMB10,SMAD7,PSMB9,ANAPC4,PSMC6,PSMC4,PSMA1
roce
ss
1.30
983
927
negative regulation of ubiquitin-protein
ligase activity
biol
ogic
al_p PSMB10,SMAD7,PSMB9,ANAPC4,PSMC6,PSMC4,PSMA1
roce
ss
1.30
983
927
positive regulation of proteolysis
biol
ogic
al_p SMAD7,ADAM8,PLK1,MDM2,NUB1,PTEN,CSNK1E
roce
ss
1.30
983
927
4
E
0
1
2.
8
5
E
0
1
2.
8
5
E
0
1
2.
8
5
E
0
1
2.
8
5
E
0
1
G
O:
00
05
92
3
tight junction
cell
ular
_co F11R,SYMPK,JAM2,DDX58,MAGI1,ESAM,TBCD,PARD6G,PMP22
mpo
nent
1.25
939
95
occluding junction
cell
ular
_co F11R,SYMPK,JAM2,DDX58,MAGI1,ESAM,TBCD,PARD6G,PMP22
mpo
nent
1.25
939
95
receptor signaling protein activity
mol
ecul
ar_f
unct
ion
IGF1R,RAF1,ZFP91,SMAD7,ADAM8,PTPN6,NOD1,FGFR1,TAB2,NF1,M
APK8IP3,RGS3,PXN,MAPK8,CSK,PTPRC,PAK1,SMAD4,MAPK12,ENG,
NOX4,MDFI,RGS2,PDGFRB,CARD14,PDCD4,NTRK1,SPRED1,TNFRS
F10B,SMAD9,DUSP6
1.11
655
906
2
G
O:
00
44
27
2
sulfur compound biosynthetic process
biol
ogic
EIF2B4,ST3GAL1,XYLT1,ST3GAL4,UST,MTRR,B4GALT4,EXT1,B3GAT
al_p
3,ACAN,FMOD
roce
ss
1.22
478
477
2
G
O:
stem cell differentiation
biol
ogic
1.19
961
G
O:
00
70
16
0
G
O:
00
05
05
7
PAX8,PAF1,MED28,NIPBL,VPS72,RUNX2,PTPRC,CDK6,STAG2,MED6,
SMARCA4,SETD2,GATA2
2.
8
5
E
0
1
2.
8
5
E
0
1
2.
8
6
E
0
1
2.
8
6
E
0
1
2.
8
00
48
86
3
G
O:
00
16
04
4
G
O:
00
08
02
2
G
O:
00
61
44
8
G
O:
00
43
21
8
al_p
roce
ss
796
2
cellular membrane organization
biol
ogic
al_p
roce
ss
protein C-terminus binding
mol
ecul
ar_f
unct
ion
CADM1,CEP135,PCGF1,MAGI1,NIPBL,USP7,SNX17,CSK,GOPC,TCF4,
DGKZ,SDCBP2,ERCC1,PABPC1
1.18
927
471
6
connective tissue development
biol
ogic
COL9A1,COL2A1,BMP8A,GLG1,FGFR1,THBS3,ZEB1,CRIP1,AACS,RU
al_p
NX2,MEF2A,OXCT1,GLI3,PDGFRB,SMAD9,ZBTB16,PKD1,ACAN
roce
ss
1.16
032
241
6
compact myelin
cell
ular
_co PTEN,PMP22
mpo
nent
1.86
577
703
6
TAZ,CPE,RAB34,HGS,CD9,DNM1L,CNP,CLN8,VAMP7,SEC31A,SNAP2
3,LMNA,GNAI1,TXNDC5,PAFAH1B1,MTCH1,PLD6,PTEN,ATP11B,RAB
8A,DENND4C,FLOT1,PAK1,RAB10,TIMM50,FLNA,SUN2,TMED2,VTI1B
,PTPRD,STAM2,NLGN2,LETM1,PDPK1,TSG101
1.10
690
642
6
8
E
0
1
2.
8
9
E
0
1
2.
8
9
E
0
1
2.
9
0
E
0
1
2.
9
2
E
0
1
G
O:
00
16
47
1
vacuolar proton-transporting V-type ATPase
complex
cell
ular
_co ATP6V1D,ATP6V0A1
mpo
nent
1.86
577
703
6
COPI-coated vesicle membrane
cell
ular
_co TMED3,TMED2
mpo
nent
1.86
577
703
6
cell cycle arrest
biol
ogic
al_p
roce
ss
PSMB10,SART1,PSMB9,UHMK1,CSNK2A1,PRKACA,ANAPC4,PLK1,W
AC,MDM2,PKD2,CASP2,RB1,PLK2,CUL4A,CHFR,CDK5RAP2,PSMC6,
CDK6,PSMC4,SGSM3,RHEB,DGKZ,ING4,CDC14B,MAPK12,HINFP,DB
F4,PSMA1,RRP8,PKD1,TSG101
1.11
114
494
8
G
O:
00
48
61
0
cellular process involved in reproduction
biol
ogic
al_p
roce
ss
SUPT5H,LEF1,SUPT4H1,APITD1,CD9,ACTR3,PRKACA,SEPT4,PMS1,
CELF1,RNF8,RHBDD1,RPL27,IFITM3,RPL9,PAFAH1B1,IL18,PLD6,RPL
24,RPL37A,MAST2,STX2,SRPK1,AFF4,STAG2,GOPC,HSD17B4,PIWIL
4,RPL4,NR2C2,ERCC1,NCBP2,DZIP1,RAD51B,RUNX1,SMARCA4,RPL
P0,CRCP,PPAP2A,ROBO2,NTRK1,ZBTB16,USF1,FOXC1,BCL2L2
1.09
041
090
3
G
O:
peptidase activator activity
mol
ecul
NLRP1,BCL2L13,NOD1,CTSH
1.46
019
G
O:
00
30
66
3
G
O:
00
07
05
0
2.
9
2
E
0
1
2.
9
2
E
0
1
2.
9
2
E
0
1
2.
9
2
E
0
1
2.
9
00
16
50
4
G
O:
00
72
02
8
G
O:
00
45
93
1
G
O:
00
06
51
3
G
O:
00
22
61
7
ar_f
unct
ion
057
8
nephron morphogenesis
biol
ogic
al_p PAX8,PKD2,PDGFRB,PKD1
roce
ss
1.45
650
081
positive regulation of mitotic cell cycle
biol
ogic
al_p ASNS,MDM2,PAFAH1B1,CUL4A
roce
ss
1.45
650
081
protein monoubiquitination
biol
ogic
al_p PCGF1,WAC,PAF1,RNF168
roce
ss
1.45
650
081
extracellular matrix disassembly
biol
ogic
al_p DPP4,MMP16,FAP,ENG
roce
ss
1.45
650
081
2
E
0
1
2.
9
4
E
0
1
2.
9
4
E
0
1
2.
9
4
E
0
1
2.
9
4
E
0
1
G
O:
00
06
91
9
activation of cysteine-type endopeptidase
activity involved in apoptotic process
biol
ogic
NLRP1,BCL2L13,BCL2L11,NOD1,SLC11A2,MTCH1,DIABLO,TNFRSF1
al_p
0B
roce
ss
1.26
801
247
protein localization to endoplasmic
reticulum
biol
ogic
GPAA1,SRP9,RPL27,RPL9,RPL24,RPL37A,OS9,RPL4,RPLP0,PDIA3,S
al_p
PCS3
roce
ss
1.21
474
555
3
B cell activation
biol
ogic
BCL6,LEF1,PTPN6,IGBP1,RC3H1,POLM,RNF8,RNF168,MEF2A,PTPR
al_p
C,SWAP70,ERCC1,LGALS8,STAT6,NTRK1
roce
ss
1.17
493
888
G
O:
00
19
20
5
nucleobase-containing compound kinase
activity
mol
ecul
ar_f
unct
ion
CMPK2,PNKP,DTYMK,AK5,UCK1
1.37
824
110
7
G
O:
neural tube development
biol
ogic
FZD6,NPHP3,VASP,STK4,NF1,PKD2,IFT172,TCTN1,GLI3,TMED2,SET
D2,PKD1,C2CD3
1.19
145
G
O:
00
70
97
2
G
O:
00
42
11
3
2.
9
5
E
0
1
2.
9
6
E
0
1
2.
9
6
E
0
1
2.
9
6
E
0
1
2.
9
00
21
91
5
G
O:
00
06
35
5
al_p
roce
ss
regulation of transcription, DNA-dependent
FZD6,PBX2,KANK2,RAI1,SIRT2,MYNN,NOC2L,ZNF131,RSC1A1,SFSW
AP,CDK13,SIN3B,CBX5,SUPT5H,BCL6,FUBP1,ZNF783,TBX2,MMS19,
CUX1,EED,SMAD7,MCF2L,HDAC6,EHMT1,ZNF496,LANCL2,LEF1,PAX
8,SUPT4H1,ZNF83,EMX2,RBPMS,ZSCAN31,XBP1,PAM,USP47,ADAM
8,GABPB1,PCGF6,EEF1A1,LHX4,CSNK2A1,IGBP1,NOD1,STAT2,PLK1
,ZNF446,PTGES2,ZNF621,HDGF,CCNL1,CHD6,ZC3H12A,FAM58A,TB
X18,LBX2,PCGF1,DR1,BCLAF1,ZNF721,ZNF397,JHDM1D,ZNF710,WA
C,ZNF142,FUBP3,ZNF540,FGFR1,HSF4,PAF1,TAB2,SGK1,DPF2,MDM
2,PRKCH,PPM1F,ZNF595,TBP,YY1,INO80,GMEB2,PFDN5,CREB1,FLII,
RPRD1A,DDX58,CCNL2,PTPRK,ZEB1,ASCC2,RGMB,EBF1,MED28,ZN
F3,RPS6KA5,NIPBL,BRD9,ZNF837,PKD2,RXRB,LMNA,MITF,RB1,PRM
biol T5,MZF1,ZFPM2,TP53BP1,ZNF865,SENP2,SUB1,CHMP1A,PDE8A,ZN
ogic F558,ZNF263,ZNF180,BICD1,ZNF276,NR1H3,USP7,FLCN,ZNF605,ZNF
al_p 410,SAP30BP,VPS72,PTEN,RUNX2,FBXW7,SMARCD3,IKBKB,RQCD1,
roce RFX7,NCOR1,MEF2A,SETD8,PIAS2,MAPK8,MYCBP2,USP15,DDX41,P
ss
BX3,ZNF565,ABCA2,AFF4,TRIM28,DMTF1,CDK5RAP2,UBP1,WDR61,E
BF4,ZNF148,ZNF76,SP110,NCK2,TCF4,IKZF5,HMGN2,SEMA4D,SSBP
2,ERC1,NFYC,SRSF10,SS18,RCOR3,SMAD4,CHURC1,CHURC1FNTB,ZNF114,MIER2,TGFB1I1,INO80E,ZNF44,CREBZF,ING4,ZNF687,
NR2C2,FHOD1,DNTTIP2,FLNA,IRF9,GLI3,MAPK12,CCDC59,DCAF6,E
NG,SIRT7,ZSCAN5A,TCF12,ARNT,ZNF692,PHF1,STK36,WWP1,PHF12
,MED6,MDFI,ZNF554,HINFP,MLX,TGS1,CDK11A,GLIS3,ELP6,BDP1,R
UNX1,SMARCA4,NAA16,LRPPRC,ZNF518B,ZNF90,ZNF638,PER3,ZNF
383,NCOR2,SETD2,IGF2,PTGIS,ATXN3,PHF21A,PDCD4,SOX13,CHD2
,STAT6,ZNF138,ZNF705A,NTRK1,TFAM,BRWD1,SMAD9,TGFBR3,ZBT
B16,BAZ2A,RRP8,PHF19,LMCD1,PKD1,PDPK1,TSG101,USF1,FOXC1,
CDK5RAP3,EYA2,SMARCAD1,CC2D1A,GATA2
729
5
1.03
149
842
5
6
E
0
1
2.
9
7
E
0
1
G
O:
00
71
35
7
G
O:
00
60
33
7
G
O:
00
46
88
7
G
O:
20
00
17
7
G
O:
00
32
cellular response to type I interferon
biol
ogic
al_p HLA-C,XAF1,PTPN6,STAT2,IFITM3,HLA-F,IRF9
roce
ss
1.29
189
626
6
type I interferon-mediated signaling
pathway
biol
ogic
al_p HLA-C,XAF1,PTPN6,STAT2,IFITM3,HLA-F,IRF9
roce
ss
1.29
189
626
6
positive regulation of hormone secretion
biol
ogic
al_p CREB1,CAPN10,AACS,PHPT1,OXCT1,C1QTNF3,RUNX1
roce
ss
1.29
189
626
6
regulation of neural precursor cell
proliferation
biol
ogic
al_p BDNF,NF1,SMARCD3,GLI3,GATA2
roce
ss
1.37
475
841
8
ARF protein signal transduction
biol
ogic
GIT2,ACAP2,CYTH2,ASAP1,PSD3
al_p
roce
1.37
475
841
8
2.
9
7
E
0
1
2.
9
7
E
0
1
2.
9
7
E
0
1
2.
9
8
E
0
1
2.
9
8
E
01
1
G
O:
00
42
15
8
G
O:
00
32
27
3
G
O:
00
05
88
4
G
O:
00
51
49
5
ss
lipoprotein biosynthetic process
biol
ogic
al_p GPAA1,PIGS,PIGG,PIGN,PIGO,ALG9
roce
ss
1.32
517
696
7
positive regulation of protein polymerization
biol
ogic
al_p ARPC4-TTLL3,ACTR3,ARPC2,WASH4P,NCK2,ACTR2
roce
ss
1.32
517
696
7
actin filament
cell
ular
_co TPM4,PKD2,IQGAP1,PAK1,EZR
mpo
nent
1.37
189
488
positive regulation of cytoskeleton
organization
biol
ogic ARPC4al_p TTLL3,ACTR3,PPM1F,ARPC2,WASH4P,PAK1,NCK2,ACTR2,FHOD1,N
roce OX4
ss
1.22
478
477
2
0
1
2.
9
8
E
0
1
2.
9
8
E
0
1
2.
9
9
E
0
1
2.
9
9
E
0
1
G
O:
00
22
41
4
G
O:
00
72
33
1
G
O:
00
70
37
1
G
O:
00
51
reproductive process
FZD6,EIF2B4,CADM1,PSMB10,IGF1R,LAMB1,F11R,CDK13,CBX5,SUP
T5H,BCL6,SPATA20,VAPB,NUP98,VRK2,LEF1,HLAC,SUPT4H1,PSMB9,ADAMTS1,BCL2L11,FDPS,PAM,RAD23A,CD9,PR
KACA,STAT2,COL16A1,JAG2,HERC2,SEPT4,TRO,CELF1,RNF8,MDM2
,RHBDD1,DAZAP1,TBP,YY1,CREB1,DDX58,RPL27,NF1,CRIP1,IFITM3,
biol
RPL9,NIPBL,CASP2,RXRB,CCNI,RB1,ZFPM2,PAFAH1B1,IL18,DNALI1,
ogic
BICD1,USP7,PLD6,CUL4A,RPL24,RPL37A,MAST2,STX2,PTEN,FYN,ID
al_p
H1,SRPK1,FBXW7,CTNS,RQCD1,GGNBP2,KPNB1,LTBR,PARN,AFF4,
roce
COL9A3,UBP1,ZNF148,SP110,GOPC,CTSH,HSD17B4,PIWIL4,KLC1,R
ss
PL4,NR2C2,TMED2,EPN1,THOC2,ERCC1,SLC25A6,WWP1,ITGA5,RG
S2,NCBP2,DZIP1,EPOR,TNFRSF14,RUNX1,SMARCA4,RPLP0,CRCP,
NCOR2,PPAP2A,DYNC1I2,TANC1,ROBO2,CLIC4,NTRK1,SPATA6,SM
AD9,ZBTB16,PKD1,TSG101,USF1,FOXC1,KPNA1,PHC2,BCL2L2,PABP
N1
signal transduction by p53 class mediator
biol
ogic
USP10,PSMB10,PSMB9,MDM2,CASP2,SETD8,PSMC6,PSMC4,ING4,P
al_p
SMA1,SPRED1,RRP8
roce
ss
1.19
756
733
3
ERK1 and ERK2 cascade
biol
ogic
PTPN6,NOD1,FLCN,FBXW7,CSK,CTSH,CSF1R,C1QTNF3,NOX4,PDGF
al_p
RB,NTRK1,DUSP6
roce
ss
1.19
756
733
3
negative regulation of cellular component
movement
biol
ogic SMAD7,NISCH,KRIT1,PTPRK,NF1,FLCN,PTEN,SRGAP2,ENG,CLIC4,T
al_p GFBR3,STK24
roce
1.19
756
733
3
1.04
845
389
1
3.
0
0
E
0
1
3.
0
1
E
0
1
3.
0
1
E
0
1
3.
0
1
E
27
1
G
O:
00
01
65
4
G
O:
00
43
43
4
G
O:
00
06
64
4
G
O:
00
09
62
8
ss
eye development
biol
ogic BDNF,TBX2,CNTF,CLN8,RAB18,HSF4,YY1,PFDN5,NF1,ZEB1,NIPBL,C
al_p ASP2,MITF,ALDH1A3,SMARCD3,CTNS,IMPDH1,GLI3,LPCAT1,PDGFR
roce B,COL8A1,SMARCA4,CLIC4,FOXC1
ss
1.12
663
128
9
response to peptide hormone stimulus
biol
ogic
al_p
roce
ss
EIF2B4,IGF1R,RAF1,EEF2K,ATP6V1D,PTPN6,PRKACA,FGFR1,ADCY4
,MDM2,EIF4B,RAB31,CAPN10,GNAI1,IL18,GRB10,FYN,PXN,DENND4C
,CSK,PAK1,LEPROT,RAB10,RHEB,GNB3,ATP6V0A1,GSK3A,IGF2,PDP
K1,USF1
1.11
038
179
9
phospholipid metabolic process
biol
ogic
al_p
roce
ss
TAZ,PLCD1,PLD1,VAPB,GPAA1,PGS1,SMPD4,FDPS,PIGS,PIGG,CLN8
,PIGN,CHKB,IDI1,GPAT2,PAFAH1B1,ISYNA1,GPCPD1,HEXA,PLD6,MT
MR14,PTEN,CSF1R,MBOAT2,LPCAT1,PDGFRB,PCYT1A,PIGO,PPAP2
A,ALG9,PLA2G16
1.10
782
919
7
response to abiotic stimulus
biol
ogic
al_p
roce
ss
EIF2B4,NOC2L,RAF1,BDNF,DPP4,PNKP,XYLT1,XBP1,PAM,USP47,AD
AM8,CD9,DHX9,ASNS,SLC11A2,RNF8,MDM2,RHBDD1,YY1,INO80,PT
PRK,NF1,CRIP1,NIPBL,ADSL,PKD2,CASP2,SLC12A6,LMNA,RNF168,IL
18,FYN,FBXW7,CTNS,LTBR,FECH,MAPK8,MYLK,PTPRC,IMPDH1,PAK
1,SMAD4,TGFB1I1,ENG,SCFD1,ARNT,NOX4,ERCC1,CIRBP,PDGFRB,
PCYT1A,PTGIS,ATXN3,TANC1,NTRK1,TNFRSF10B,SMAD9,TGFBR3,P
LOD2,PKD1,PDPK1,USF1
1.07
090
155
7
0
1
3.
0
1
E
0
1
3.
0
1
E
0
1
3.
0
1
E
0
1
3.
0
2
E
0
1
G
O:
00
90
31
6
positive regulation of intracellular protein
transport
biol
ogic
al_p RBPMS,PRKACA,MDM2,DDX58,SMAD4,FLNA,GLI3,KPNA1,UBR5
roce
ss
1.23
728
257
6
pore complex
cell
ular
_co NUP98,NUTF2,NUP210,SENP2,KPNB1,NUP37,NUP85,KPNA1
mpo
nent
1.25
782
721
6
inclusion body
cell
ular
_co NUP98,HDAC6,CARD14,ATXN3
mpo
nent
1.43
521
310
5
G
O:
00
09
92
5
basal plasma membrane
cell
ular
_co ITGA9,PKD2,SLC23A2
mpo
nent
1.55
481
419
7
G
O:
00
30
regulation of vascular endothelial growth
factor receptor signaling pathway
biol
ogic
GRB10,ARNT,ITGA5
al_p
roce
1.55
453
451
8
G
O:
00
46
93
0
G
O:
00
16
23
4
3.
0
3
E
0
1
3.
0
3
E
0
1
3.
0
3
E
0
1
3.
0
3
E
0
1
3.
0
3
E
94
7
G
O:
00
32
87
3
G
O:
00
10
86
2
G
O:
00
14
91
0
G
O:
00
45
49
4
ss
negative regulation of stress-activated
MAPK cascade
biol
ogic
al_p IGBP1,PAFAH1B1,NCOR1
roce
ss
1.55
453
451
8
positive regulation of pathway-restricted
SMAD protein phosphorylation
biol
ogic
al_p RBPMS,SMAD4,ENG
roce
ss
1.55
453
451
8
regulation of smooth muscle cell migration
biol
ogic
al_p NRP1,NOX4,PDGFRB
roce
ss
1.55
453
451
8
photoreceptor cell maintenance
biol
ogic
al_p NPHP3,CLN8,BBS1
roce
ss
1.55
453
451
8
0
1
3.
0
3
E
0
1
3.
0
3
E
0
1
3.
0
3
E
0
1
3.
0
3
E
0
1
G
O:
00
31
06
0
G
O:
00
70
30
3
G
O:
00
32
86
9
G
O:
00
60
34
1
G
O:
00
05
regulation of histone methylation
biol
ogic
al_p WDR61,PHF1,PHF19
roce
ss
1.55
453
451
8
negative regulation of stress-activated
protein kinase signaling cascade
biol
ogic
al_p IGBP1,PAFAH1B1,NCOR1
roce
ss
1.55
453
451
8
cellular response to insulin stimulus
biol
ogic
IGF1R,RAF1,EEF2K,ATP6V1D,FGFR1,EIF4B,RAB31,CAPN10,GRB10,
al_p
DENND4C,PAK1,RAB10,RHEB,ATP6V0A1,GSK3A,IGF2,PDPK1,USF1
roce
ss
1.14
932
409
9
regulation of cellular localization
biol
ogic
al_p
roce
ss
CADM1,RALGAPA2,NLRP1,SEPT5,SYTL4,PAX8,RBPMS,PAM,UHMK1,
ADAM8,PRKACA,DNM1L,VAMP7,CAMK2D,DISP1,SNCAIP,MDM2,FKB
P1A,CREB1,DDX58,RHBDF1,NF1,CAPN10,PKD2,RB1,AACS,GCC2,NR
1H3,FLCN,IQGAP1,PHPT1,OXCT1,ABCA2,CSK,GOPC,LEPROT,CSF1
R,SMAD4,C1QTNF3,FLNA,RAB5A,GLI3,SCFD1,SLC25A6,VAMP4,MDFI
,NCBP2,RAP1B,RUNX1,RHBDF2,SPCS3,PKD1,PDPK1,KPNA1,UBR5
1.07
546
413
2
microtubule
cell
ular
_co
mpo
SIRT2,GAS8,HDAC6,DYNC1I1,TTLL3,BCL2L11,PLK1,DNM1L,CNP,INO
80,NUMA1,PAFAH1B1,BICD1,IQGAP1,NCOR1,CDK5RAP2,TBCD,KIFC
2,SS18,KLC1,NAV1,TBCE,HAUS5,CLIP2,LRPPRC,KIF13B,DYNC1I2,CL
ASP1
1.11
310
561
8
3.
0
3
E
0
1
3.
0
3
E
0
1
3.
0
4
E
0
1
3.
0
4
E
0
1
3.
0
4
E
87
4
G
O:
00
04
17
5
G
O:
00
45
59
7
G
O:
00
60
17
3
G
O:
00
48
73
6
nent
endopeptidase activity
mol
ecul
ar_f
unct
ion
USP10,PSMB10,RAF1,NLRP1,DDI2,DPP4,NLN,CASP4,LEF1,PSMB9,A
DAMTS1,BCL2L13,BCL2L11,USP47,ADAM8,CSNK2A1,IGBP1,NOD1,P
REPL,SLC11A2,ATG4B,USP20,C2,CFB,MMP16,MDM2,RHBDD1,PPM1
F,RHBDF1,SERPINH1,CAPN10,CASP2,MTCH1,TPP1,ADAM15,USP33,
USP7,FAP,C1R,LGMN,HERPUD1,ADAMTS18,USP15,CTSH,C3,C1S,P
CSK7,DIABLO,RHBDF2,PDIA3,LONP2,PSMA1,TNFRSF10B,CPAMD8,
MMP25
1.07
506
795
5
positive regulation of cell differentiation
biol
ogic
al_p
roce
ss
BDNF,SART1,IL15RA,LEF1,PAX8,ADAM8,ACTR3,ZC3H12A,FGFR1,HS
F4,CAPRIN1,PRKCH,CREB1,NPTN,ZEB1,RB1,BLOC1S5,PAFAH1B1,A
RPC2,RUNX2,SMARCD3,MEF2A,PTPRC,TCF4,SEMA4D,SMAD4,TGFB
1I1,CD276,GLI3,MAPK12,TCF12,ARNT,PTPRD,RUNX1,ACIN1,ROBO2,
BNIP2,SMAD9,ZBTB16,TENM4,GATA2
1.08
950
282
5
limb development
biol
ogic
PBX2,COL2A1,TBX2,LEF1,PAM,FGFR1,NIPBL,ACD,LMBR1,GLI3,SMA
al_p
RCA4,ZBTB16,C2CD3
roce
ss
1.18
340
690
8
appendage development
biol
ogic
PBX2,COL2A1,TBX2,LEF1,PAM,FGFR1,NIPBL,ACD,LMBR1,GLI3,SMA
al_p
RCA4,ZBTB16,C2CD3
roce
ss
1.18
340
690
8
0
1
3.
0
5
E
0
1
3.
0
5
E
0
1
3.
0
5
E
0
1
3.
0
5
E
0
1
G
O:
00
05
51
6
G
O:
00
04
14
3
G
O:
00
15
38
5
G
O:
00
35
25
5
G
O:
00
04
calmodulin binding
mol
ecul
ar_f
unct
ion
diacylglycerol kinase activity
mol
ecul
ar_f
unct
ion
sodium:hydrogen antiporter activity
mol
ecul
ar_f
unct
ion
ionotropic glutamate receptor binding
mol
ecul
ar_f
unct
ion
alkaline phosphatase activity
mol
ecul
ar_f
unct
MYO1D,ATP2B1,EEF2K,CAMK2D,STRN4,IQGAP1,MYLK,CDK5RAP2,P
HKG2,ADD3,RASGRF2,RGS2,MYO1E,PHKG1
1.17
450
111
7
DGKA,DGKZ
1.80
090
171
3
SLC9A5,SLC9A8
1.80
090
171
3
FLOT1,CANX
1.80
090
171
3
MEF2A,SEMA4D
1.80
090
171
3
3.
0
5
E
0
1
3.
0
6
E
0
1
3.
0
6
E
0
1
3.
0
6
E
0
1
3.
0
6
E
03
5
G
O:
00
05
52
7
G
O:
00
15
24
8
G
O:
00
04
01
2
G
O:
00
05
52
8
ion
macrolide binding
mol
ecul
ar_f
unct
ion
sterol transporter activity
mol
ecul
ar_f
unct
ion
phospholipid-translocating ATPase activity
mol
ecul
ar_f
unct
ion
FK506 binding
mol
ecul
ar_f
unct
ion
FKBP1A,FKBP10
1.80
090
171
3
NPC1,STARD3
1.80
090
171
3
ATP11B,ATP8B2
1.80
090
171
3
FKBP1A,FKBP10
1.80
090
171
3
0
1
3.
0
6
E
0
1
3.
0
6
E
0
1
3.
0
6
E
0
1
3.
0
6
E
0
1
G
O:
00
03
99
5
acyl-CoA dehydrogenase activity
mol
ecul
ar_f
unct
ion
cellular membrane fusion
biol
ogic
al_p RAB34,CD9,VAMP7,SNAP23,GNAI1,PLD6,RAB8A,VTI1B
roce
ss
1.25
326
813
9
anterograde synaptic vesicle transport
biol
ogic
al_p AP3S2,BLOC1S5
roce
ss
1.79
635
099
9
G
O:
00
31
44
0
regulation of mRNA 3-end processing
biol
ogic
al_p PAF1,PABPC1
roce
ss
1.79
635
099
9
G
O:
00
00
retrograde transport, vesicle recycling within
Golgi
biol
ogic
CUX1,GCC2
al_p
roce
1.79
635
099
9
G
O:
00
06
94
4
G
O:
00
48
49
0
ACADVL,GCDH
1.80
090
171
3
3.
0
6
E
0
1
3.
0
6
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
30
1
G
O:
00
32
10
6
G
O:
00
70
49
8
G
O:
00
09
29
9
G
O:
00
72
11
1
ss
positive regulation of response to
extracellular stimulus
biol
ogic
al_p SUPT5H,WAC
roce
ss
1.79
635
099
9
interleukin-1-mediated signaling pathway
biol
ogic
al_p VRK2,RPS6KA5
roce
ss
1.79
635
099
9
mRNA transcription
biol
ogic
al_p ARNT,USF1
roce
ss
1.79
635
099
9
cell proliferation involved in kidney
development
biol
ogic
al_p FLCN,PDGFRB
roce
ss
1.79
635
099
9
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
G
O:
00
32
10
9
positive regulation of response to nutrient
levels
biol
ogic
al_p SUPT5H,WAC
roce
ss
1.79
635
099
9
regulation of centrosome duplication
biol
ogic
al_p PLK2,CDK5RAP2
roce
ss
1.79
635
099
9
negative regulation of calcium ion
transmembrane transporter activity
biol
ogic
al_p FKBP1A,PKD2
roce
ss
1.79
635
099
9
G
O:
00
06
34
9
regulation of gene expression by genetic
imprinting
biol
ogic
al_p EED,IGF2
roce
ss
1.79
635
099
9
G
O:
00
72
glomerular visceral epithelial cell
differentiation
biol
ogic
IQGAP1,MYO1E
al_p
roce
1.79
635
099
9
G
O:
00
10
82
4
G
O:
19
01
02
0
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
11
2
G
O:
00
34
66
1
G
O:
00
09
07
1
G
O:
00
43
58
4
G
O:
00
48
20
8
ss
ncRNA catabolic process
biol
ogic
al_p XRN1,DIS3L
roce
ss
1.79
635
099
9
serine family amino acid catabolic process
biol
ogic
al_p AMT,THNSL2
roce
ss
1.79
635
099
9
nose development
biol
ogic
al_p ALDH1A3,GLI3
roce
ss
1.79
635
099
9
COPII vesicle coating
biol
ogic
al_p SEC31A,TMED2
roce
ss
1.79
635
099
9
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
G
O:
00
09
31
2
oligosaccharide biosynthetic process
biol
ogic
al_p MPDU1,ST6GALNAC5
roce
ss
1.79
635
099
9
vesicle transport along microtubule
biol
ogic
al_p DYNC1I1,PAFAH1B1
roce
ss
1.79
635
099
9
Sertoli cell differentiation
biol
ogic
al_p HSD17B4,NTRK1
roce
ss
1.79
635
099
9
G
O:
00
48
20
7
vesicle targeting, rough ER to cis-Golgi
biol
ogic
al_p SEC31A,TMED2
roce
ss
1.79
635
099
9
G
O:
00
09
aspartate family amino acid catabolic
process
biol
ogic
GCDH,DLST
al_p
roce
1.79
635
099
9
G
O:
00
47
49
6
G
O:
00
60
00
8
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
06
8
G
O:
00
61
31
8
G
O:
00
43
49
6
G
O:
00
46
64
1
G
O:
00
31
51
4
ss
renal filtration cell differentiation
biol
ogic
al_p IQGAP1,MYO1E
roce
ss
1.79
635
099
9
regulation of protein homodimerization
activity
biol
ogic
al_p CRBN,MEF2A
roce
ss
1.79
635
099
9
positive regulation of alpha-beta T cell
proliferation
biol
ogic
al_p IL18,PTPRC
roce
ss
1.79
635
099
9
motile cilium
cell
ular
GAS8,TTLL3,BBS1,PKD2,TCTN1,CLTB,WDR35,EVC,DZIP1,CC2D2A,T
_co
MEM237,SEPT2
mpo
nent
1.19
092
151
3
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
3.
0
7
E
0
1
G
O:
00
44
34
4
G
O:
00
16
29
8
G
O:
00
42
33
0
G
O:
00
06
93
5
G
O:
00
06
cellular response to fibroblast growth factor
stimulus
biol
ogic
RAF1,PRKACA,FGFR1,ADCY4,MDM2,CREB1,NPTN,PTEN,RUNX2,FIB
al_p
P,FGF14,GSK3A,DUSP6,PDPK1
roce
ss
1.17
153
326
lipase activity
mol
ecul
ar_f
unct
ion
PLCD1,PLD1,SMPD4,PRKACA,PLCB4,FGFR1,ADCY4,FKBP1A,CREB1
,ANXA5,BICD1,NR1H3,PLD6,RGS2,PDGFRB,PDIA3,NTRK1,LMF1,PLA
2G16
1.14
057
108
5
taxis
biol
ogic
al_p
roce
ss
LAMB1,RAF1,COL9A1,BDNF,COL2A1,PLD1,ARHGEF12,CD72,LEF1,IT
GA9,ADAM8,LHX4,VASP,CSNK2A1,FGFR1,PDE4D,PPM1F,CREB1,RG
MB,RPS6KA5,MAPK8IP3,USP33,NRP1,FYN,SRGAP2,CACNB1,MYCBP
2,COL9A3,PTPRC,RARRES2,RANBP9,PAK1,NCK2,SEMA6A,SEMA4D,
ROBO3,EZR,GLI3,ENG,EXT1,UNC5B,NUP85,ITGA5,PDGFRB,TLN1,R
OBO2,CACNB3,NTRK1,CLASP1
1.07
869
116
4
chemotaxis
biol
ogic
al_p
roce
ss
LAMB1,RAF1,COL9A1,BDNF,COL2A1,PLD1,ARHGEF12,CD72,LEF1,IT
GA9,ADAM8,LHX4,VASP,CSNK2A1,FGFR1,PDE4D,PPM1F,CREB1,RG
MB,RPS6KA5,MAPK8IP3,USP33,NRP1,FYN,SRGAP2,CACNB1,MYCBP
2,COL9A3,PTPRC,RARRES2,RANBP9,PAK1,NCK2,SEMA6A,SEMA4D,
ROBO3,EZR,GLI3,ENG,EXT1,UNC5B,NUP85,ITGA5,PDGFRB,TLN1,R
OBO2,CACNB3,NTRK1,CLASP1
1.07
869
116
4
cellular amino acid metabolic process
biol
ogic
al_p
roce
EIF2B4,PSMB10,CKB,PTS,TARS,ENOSF1,SHMT2,AMT,NARS,GLS,PA
X8,PSMB9,ASNS,GCDH,RARS,ALDH18A1,ALDH6A1,GARS,IDH1,CTN
S,OAZ1,PSMC6,FARSA,PSMC4,PPA2,P4HB,DDAH1,MTRR,DLST,THN
SL2,NOX4,FPGS,PSMA1,CARS2,VARS,LARS,DDAH2,PLA2G16
1.09
159
922
1
3.
0
8
E
0
1
3.
0
9
E
0
1
3.
0
9
E
0
1
3.
0
9
E
0
1
3.
0
9
E
52
0
G
O:
00
06
63
9
G
O:
00
48
59
8
G
O:
00
50
68
1
G
O:
00
34
34
0
ss
acylglycerol metabolic process
biol
ogic
PGS1,HSD17B12,PRKACA,GPAT2,NR1H3,FBXW7,C3,ELOVL1,LPCAT
al_p
1,LMF1
roce
ss
1.21
375
067
5
embryonic morphogenesis
biol
ogic
al_p
roce
ss
FZD6,PBX2,NPHP3,COL2A1,SUPT20H,TBX2,LEF1,PAX8,VASP,PRKA
CA,JAG2,TBX18,STK4,FGFR1,PAF1,ZEB1,NIPBL,PKD2,ALDH1A3,RUN
X2,IFT172,MEF2A,TCTN1,TRIM28,ACD,SMAD4,TGFB1I1,LMBR1,GLI3,
TMED2,ENG,EXT1,MDFI,SMARCA4,SETD2,DUSP6,ZBTB16,FOXC1,C2
CD3,EYA2,TENM4,GATA2
1.08
608
553
7
androgen receptor binding
mol
ecul
ar_f
unct
ion
RB1,PIAS2,TGFB1I1,SMARCA4
1.42
176
451
response to type I interferon
biol
ogic
al_p HLA-C,XAF1,PTPN6,STAT2,IFITM3,HLA-F,IRF9
roce
ss
1.27
443
820
9
0
1
3.
0
9
E
0
1
3.
0
9
E
0
1
3.
0
9
E
0
1
3.
0
9
E
0
1
G
O:
00
06
40
5
G
O:
00
48
02
9
G
O:
00
51
53
6
G
O:
00
51
54
0
G
O:
00
00
RNA export from nucleus
biol
ogic
al_p DDX39A,UPF1,FYTTD1,SRSF10,THOC2,NCBP2,PABPN1
roce
ss
1.27
443
820
9
monosaccharide binding
mol
ecul
ar_f
unct
ion
LEPRE1,PAM,ALKBH3,OGFOD3,ENG,PLOD2
1.30
710
608
2
iron-sulfur cluster binding
mol
ecul
ar_f
unct
ion
TYW1B,FECH,NDUFV1,NDUFS2,NUBP1,CDK5RAP1
1.30
710
608
2
metal cluster binding
mol
ecul
ar_f
unct
ion
TYW1B,FECH,NDUFV1,NDUFS2,NUBP1,CDK5RAP1
1.30
710
608
2
THO complex
cell
ular
THOC2
_co
mpo
2.79
866
555
5
3.
0
9
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
34
7
G
O:
00
05
82
8
G
O:
00
43
24
5
G
O:
00
44
21
7
G
O:
00
05
85
3
nent
kinetochore microtubule
cell
ular
_co CLASP1
mpo
nent
2.79
866
555
5
extraorganismal space
cell
ular
_co BICD1
mpo
nent
2.79
866
555
5
other organism part
cell
ular
_co BICD1
mpo
nent
2.79
866
555
5
eukaryotic translation elongation factor 1
complex
cell
ular
_co EEF1A1
mpo
nent
2.79
866
555
5
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
G
O:
00
46
54
0
G
O:
00
71
81
7
G
O:
00
00
44
5
G
O:
00
30
28
9
G
O:
00
71
U4/U6 x U5 tri-snRNP complex
cell
ular
_co PRPF3
mpo
nent
2.79
866
555
5
MMXD complex
cell
ular
_co MMS19
mpo
nent
2.79
866
555
5
THO complex part of transcription export
complex
cell
ular
_co THOC2
mpo
nent
2.79
866
555
5
protein phosphatase 4 complex
cell
ular
_co SMEK1
mpo
nent
2.79
866
555
5
SMAD protein complex
cell
ular
SMAD4
_co
mpo
2.79
866
555
5
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
14
1
G
O:
00
30
12
3
G
O:
00
31
08
8
G
O:
00
42
10
5
G
O:
00
33
64
3
nent
AP-3 adaptor complex
cell
ular
_co AP3S2
mpo
nent
2.79
866
555
5
platelet dense granule membrane
cell
ular
_co CD63
mpo
nent
2.79
866
555
5
alpha-beta T cell receptor complex
cell
ular
_co PTPN6
mpo
nent
2.79
866
555
5
host cell part
cell
ular
_co BICD1
mpo
nent
2.79
866
555
5
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
G
O:
00
05
76
7
G
O:
00
43
65
7
G
O:
00
18
99
5
G
O:
00
97
03
8
G
O:
00
44
secondary lysosome
cell
ular
_co ADAM8
mpo
nent
2.79
866
555
5
host cell
cell
ular
_co BICD1
mpo
nent
2.79
866
555
5
host
cell
ular
_co BICD1
mpo
nent
2.79
866
555
5
perinuclear endoplasmic reticulum
cell
ular
_co OSBPL3
mpo
nent
2.79
866
555
5
other organism
cell
ular
BICD1
_co
mpo
2.79
866
555
5
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
0
E
21
5
G
O:
00
05
67
2
G
O:
00
44
21
6
G
O:
00
32
00
6
G
O:
00
55
01
3
nent
transcription factor TFIIA complex
cell
ular
_co TBP
mpo
nent
2.79
866
555
5
other organism cell
cell
ular
_co BICD1
mpo
nent
2.79
866
555
5
regulation of TOR signaling cascade
biol
ogic
al_p FLCN,RHEB,GOLPH3,GSK3A
roce
ss
1.41
817
184
1
cardiac muscle cell development
biol
ogic
al_p LMNA,MEF2A,PDGFRB,GSK3A
roce
ss
1.41
817
184
1
0
1
3.
1
0
E
0
1
3.
1
0
E
0
1
3.
1
1
E
0
1
3.
1
1
E
0
1
G
O:
00
46
67
7
G
O:
00
06
90
3
G
O:
00
45
63
9
G
O:
00
30
14
8
G
O:
00
71
response to antibiotic
biol
ogic
al_p ACTR3,MDM2,CRIP1,MEF2A
roce
ss
1.41
817
184
1
vesicle targeting
biol
ogic
al_p SEPT5,SEC31A,SNAP23,TMED2
roce
ss
1.41
817
184
1
positive regulation of myeloid cell
differentiation
biol
ogic
al_p LEF1,RB1,ARNT,RUNX1,ACIN1,GATA2
roce
ss
1.30
380
314
5
sphingolipid biosynthetic process
biol
ogic
al_p VAPB,SMPD4,CLN8,ST6GALNAC5,ELOVL1,PPAP2A
roce
ss
1.30
380
314
5
cellular response to carbohydrate stimulus
biol
ogic
PRKACA,AACS,PHPT1,MEF2A,OXCT1,NOX4
al_p
roce
1.30
380
314
5
3.
1
1
E
0
1
3.
1
1
E
0
1
3.
1
2
E
0
1
3.
1
2
E
0
1
3.
1
2
E
32
2
G
O:
00
31
64
6
G
O:
00
30
16
6
G
O:
00
42
30
8
G
O:
00
07
09
1
ss
positive regulation of neurological system
process
biol
ogic
al_p NPTN,PLK2,PTEN,NLGN2,NTRK1,TENM4
roce
ss
1.30
380
314
5
proteoglycan biosynthetic process
biol
ogic
al_p XYLT1,UST,EXT1,B3GAT3,ACAN
roce
ss
1.34
726
324
9
negative regulation of protein import into
nucleus
biol
ogic
al_p NF1,PKD2,C1QTNF3,MDFI,PKD1
roce
ss
1.34
726
324
9
mitotic metaphase/anaphase transition
biol
ogic
al_p ANAPC4,PLK1,RB1,PTEN,STAG2
roce
ss
1.34
726
324
9
0
1
3.
1
2
E
0
1
3.
1
3
E
0
1
3.
1
3
E
0
1
3.
1
3
E
0
1
G
O:
00
31
04
7
gene silencing by RNA
biol
ogic
al_p TNRC6A,CELF1,PIWIL4,NCBP2,PABPC1
roce
ss
1.34
726
324
9
membrane organization
biol
ogic
al_p
roce
ss
1.09
406
528
4
positive regulation of growth
biol
ogic
DERL2,LEF1,USP47,CSNK2A1,CELF1,PPM1F,INO80,CREB1,NIPBL,N
al_p
OL8,PAFAH1B1,N6AMT1,SEMA4D
roce
ss
1.17
546
458
G
O:
00
51
24
9
regulation of lymphocyte activation
biol
ogic SART1,HLA-DPB1,DPP4,BCL6,PTPN22,IL15RA,HLAal_p DQA1,ADAM8,PTPN6,RC3H1,ZEB1,IL18,FYN,MEF2A,CSK,PTPRC,PAK
roce 1,NCK2,CD276,GLI3,LGALS8,TNFRSF14,IGF2,STAT6,PDPK1
ss
1.11
528
414
7
G
O:
20
00
regulation of cysteine-type endopeptidase
activity
biol
ogic RAF1,NLRP1,LEF1,BCL2L13,BCL2L11,USP47,CSNK2A1,IGBP1,NOD1,
al_p SLC11A2,MDM2,PPM1F,MTCH1,HERPUD1,DIABLO,TNFRSF10B
roce
1.15
273
860
9
G
O:
00
61
02
4
G
O:
00
45
92
7
TAZ,CPE,RAB34,HGS,CD9,DNM1L,CNP,CLN8,VAMP7,SEC31A,SNAP2
3,LMNA,GNAI1,TXNDC5,PAFAH1B1,MTCH1,PLD6,PTEN,ATP11B,RAB
8A,DENND4C,FLOT1,PAK1,RAB10,TIMM50,FLNA,SUN2,TMED2,VTI1B
,PTPRD,STAM2,NLGN2,LETM1,PDPK1,TSG101
3.
1
3
E
0
1
3.
1
3
E
0
1
3.
1
3
E
0
1
3.
1
4
E
0
1
3.
1
4
E
11
6
G
O:
00
16
57
3
G
O:
00
14
70
6
G
O:
00
00
00
3
ss
histone acetylation
biol
ogic
NOC2L,LEF1,DR1,PHF15,RPS6KA5,FLCN,ING4,MSL1,SMARCA4,KAN
al_p
SL3,GATA2
roce
ss
1.19
515
288
2
striated muscle tissue development
biol
ogic SIRT2,BDNF,TAZ,SIN3B,LUC7L,TBX2,SMAD7,LEF1,FGFR1,FKBP1A,N
al_p F1,RXRB,LMNA,ZFPM2,PTEN,MEF2A,PAK1,GAA,PDGFRB,GSK3A,GP
roce HN,TANC1,TGFBR3,FOXC1,EYA2,TENM4
ss
1.11
202
680
9
reproduction
FZD6,EIF2B4,CADM1,PSMB10,IGF1R,LAMB1,F11R,CDK13,CBX5,SUP
T5H,BCL6,SPATA20,VAPB,NUP98,VRK2,LEF1,HLAC,SUPT4H1,PSMB9,ADAMTS1,BCL2L11,FDPS,PAM,RAD23A,APITD1,
CD9,ACTR3,PRKACA,STAT2,COL16A1,JAG2,HERC2,SEPT4,TRO,PM
S1,CELF1,RNF8,MDM2,RHBDD1,DAZAP1,TBP,YY1,CREB1,DDX58,RP
biol
L27,NF1,CRIP1,IFITM3,RPL9,NIPBL,CASP2,RXRB,CCNI,RB1,ZFPM2,P
ogic
AFAH1B1,IL18,DNALI1,BICD1,HEXA,USP7,PLD6,CUL4A,RPL24,RPL37
al_p
A,MAST2,STX2,PTEN,FYN,IDH1,SRPK1,FBXW7,CTNS,RQCD1,GGNB
roce
P2,KPNB1,LTBR,PARN,AFF4,COL9A3,UBP1,ZNF148,STAG2,SP110,G
ss
OPC,CTSH,HSD17B4,PIWIL4,KLC1,RPL4,NR2C2,TMED2,EPN1,THOC
2,ERCC1,SLC25A6,WWP1,ITGA5,RGS2,NCBP2,DZIP1,RAD51B,EPOR,
TNFRSF14,RUNX1,SMARCA4,RPLP0,CRCP,NCOR2,PPAP2A,DYNC1I
2,TANC1,ROBO2,CLIC4,NTRK1,SPATA6,SMAD9,ZBTB16,PKD1,TSG10
1,USF1,FOXC1,KPNA1,PHC2,BCL2L2,PABPN1
1.04
336
305
7
0
1
3.
1
4
E
0
1
3.
1
4
E
0
1
3.
1
5
E
0
1
G
O:
00
47
48
5
G
O:
00
09
89
8
G
O:
00
71
77
4
G
O:
00
02
36
6
G
O:
00
02
protein N-terminus binding
mol
ecul
ar_f
unct
ion
internal side of plasma membrane
cell
ular
_co PTPN22,NF1,GNAI1,PTEN,IKBKB,RGS2,PTPN4,DIABLO,FARP1
mpo
nent
1.22
271
796
1
response to fibroblast growth factor stimulus
biol
ogic
RAF1,PRKACA,FGFR1,ADCY4,MDM2,CREB1,NPTN,PTEN,RUNX2,FIB
al_p
P,FGF14,GSK3A,DUSP6,PDPK1
roce
ss
1.16
430
157
4
leukocyte activation involved in immune
response
biol
ogic
BCL6,LEF1,RC3H1,VAMP7,RNF8,RNF168,PTPRC,SWAP70,ERCC1,LG
al_p
ALS8,STAT6,PDPK1
roce
ss
1.18
008
459
8
cell activation involved in immune response
biol
ogic BCL6,LEF1,RC3H1,VAMP7,RNF8,RNF168,PTPRC,SWAP70,ERCC1,LG
al_p ALS8,STAT6,PDPK1
roce
1.18
008
459
8
PDLIM5,CSNK2A1,NIPBL,SRRM2,SCFD1,SMARCA4,NCOR2,MAU2
1.24
200
118
2
3.
1
5
E
0
1
3.
1
5
E
0
1
3.
1
6
E
0
1
3.
1
8
E
0
1
3.
1
8
E
26
3
G
O:
00
05
85
2
G
O:
00
30
86
7
G
O:
00
06
63
8
G
O:
00
30
53
4
ss
eukaryotic translation initiation factor 3
complex
cell
ular
_co EIF3M,EIF3I
mpo
nent
1.74
916
597
2
rough endoplasmic reticulum membrane
cell
ular
_co SRP9,PLOD2
mpo
nent
1.74
916
597
2
neutral lipid metabolic process
biol
ogic
PGS1,HSD17B12,PRKACA,GPAT2,NR1H3,FBXW7,C3,ELOVL1,LPCAT
al_p
1,LMF1
roce
ss
1.20
291
361
5
adult behavior
biol
ogic
al_p NPC1,CNP,CLN8,GIGYF2,PAFAH1B1,HEXA,CTNS,PBX3,TBCE,FGF14
roce
ss
1.20
291
361
5
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
G
O:
00
31
82
1
G-protein coupled serotonin receptor
binding
mol
ecul
ar_f
unct
ion
GNAI1
2.70
135
257
interleukin-2 receptor binding
mol
ecul
ar_f
unct
ion
TIMM50
2.70
135
257
neurotrophin receptor activity
mol
ecul
ar_f
unct
ion
NTRK1
2.70
135
257
G
O:
00
04
59
6
peptide alpha-N-acetyltransferase activity
mol
ecul
ar_f
unct
ion
NAA10
2.70
135
257
G
O:
00
30
transforming growth factor beta receptor,
pathway-specific cytoplasmic mediator
activity
mol
ecul
ar_f
unct
SMAD9
2.70
135
257
G
O:
00
05
13
4
G
O:
00
05
03
0
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
61
8
G
O:
00
31
68
5
G
O:
00
42
28
5
G
O:
00
32
45
4
G
O:
00
05
00
7
ion
adenosine receptor binding
mol
ecul
ar_f
unct
ion
USP4
2.70
135
257
xylosyltransferase activity
mol
ecul
ar_f
unct
ion
XYLT1
2.70
135
257
histone demethylase activity (H3-K9
specific)
mol
ecul
ar_f
unct
ion
JHDM1D
2.70
135
257
fibroblast growth factor-activated receptor
activity
mol
ecul
ar_f
unct
ion
FGFR1
2.70
135
257
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
G
O:
00
16
72
3
G
O:
00
16
41
3
G
O:
00
04
36
6
G
O:
00
16
72
4
G
O:
00
42
oxidoreductase activity, oxidizing metal
ions, NAD or NADP as acceptor
mol
ecul
ar_f
unct
ion
MTRR
2.70
135
257
O-acetyltransferase activity
mol
ecul
ar_f
unct
ion
LPCAT1
2.70
135
257
glycerol-3-phosphate O-acyltransferase
activity
mol
ecul
ar_f
unct
ion
GPAT2
2.70
135
257
oxidoreductase activity, oxidizing metal
ions, oxygen as acceptor
mol
ecul
ar_f
unct
ion
CP
2.70
135
257
CD4 receptor binding
mol
ecul
ar_f
unct
FYN
2.70
135
257
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
60
9
G
O:
00
31
40
2
G
O:
00
16
42
3
G
O:
00
34
23
6
G
O:
00
35
25
2
ion
sodium ion binding
mol
ecul
ar_f
unct
ion
PDXK
2.70
135
257
tRNA (guanine) methyltransferase activity
mol
ecul
ar_f
unct
ion
WDR4
2.70
135
257
protein kinase A catalytic subunit binding
mol
ecul
ar_f
unct
ion
GSK3A
2.70
135
257
UDP-xylosyltransferase activity
mol
ecul
ar_f
unct
ion
XYLT1
2.70
135
257
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
G
O:
00
04
61
4
phosphoglucomutase activity
mol
ecul
ar_f
unct
ion
PGM2
2.70
135
257
3-chloroallyl aldehyde dehydrogenase
activity
mol
ecul
ar_f
unct
ion
ALDH3B1
2.70
135
257
sodium-independent organic anion
transmembrane transporter activity
mol
ecul
ar_f
unct
ion
SLCO2B1
2.70
135
257
G
O:
00
70
29
0
NAPE-specific phospholipase D activity
mol
ecul
ar_f
unct
ion
PLD1
2.70
135
257
G
O:
00
43
vascular endothelial growth factor receptor
2 binding
mol
ecul
ar_f
unct
ITGA5
2.70
135
257
G
O:
00
04
02
8
G
O:
00
15
34
7
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
18
4
G
O:
00
16
71
5
G
O:
00
04
30
1
G
O:
00
04
84
9
G
O:
00
04
82
6
ion
oxidoreductase activity, acting on paired
donors, with incorporation or reduction of
molecular oxygen, reduced ascorbate as
one donor, and incorporation of one atom of
oxygen
mol
ecul
ar_f
unct
ion
PAM
2.70
135
257
epoxide hydrolase activity
mol
ecul
ar_f
unct
ion
EPHX2
2.70
135
257
uridine kinase activity
mol
ecul
ar_f
unct
ion
UCK1
2.70
135
257
phenylalanine-tRNA ligase activity
mol
ecul
ar_f
unct
ion
FARSA
2.70
135
257
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
G
O:
00
03
87
8
G
O:
00
42
60
8
G
O:
00
04
32
2
G
O:
00
05
10
5
G
O:
00
71
ATP citrate synthase activity
mol
ecul
ar_f
unct
ion
PHPT1
2.70
135
257
T cell receptor binding
mol
ecul
ar_f
unct
ion
FYN
2.70
135
257
ferroxidase activity
mol
ecul
ar_f
unct
ion
CP
2.70
135
257
type 1 fibroblast growth factor receptor
binding
mol
ecul
ar_f
unct
ion
NPTN
2.70
135
257
cellular response to UV-B
biol
ogic
CRIP1
al_p
roce
2.69
452
649
9
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
1
9
E
0
1
3.
2
0
E
49
3
G
O:
00
02
56
8
G
O:
20
00
83
3
G
O:
00
72
25
7
G
O:
00
10
13
8
ss
somatic diversification of T cell receptor
genes
biol
ogic
al_p LEF1
roce
ss
2.69
452
649
9
positive regulation of steroid hormone
secretion
biol
ogic
al_p RUNX1
roce
ss
2.69
452
649
9
metanephric nephron tubule epithelial cell
differentiation
biol
ogic
al_p PAX8
roce
ss
2.69
452
649
9
pyrimidine ribonucleotide salvage
biol
ogic
al_p UCK1
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
46
46
9
platelet activating factor metabolic process
biol
ogic
al_p PAFAH1B1
roce
ss
2.69
452
649
9
Mullerian duct regression
biol
ogic
al_p SMAD9
roce
ss
2.69
452
649
9
regulation of vacuole organization
biol
ogic
al_p TBC1D14
roce
ss
2.69
452
649
9
G
O:
00
72
22
3
metanephric glomerular mesangium
development
biol
ogic
al_p PDGFRB
roce
ss
2.69
452
649
9
G
O:
00
32
negative regulation of telomere
maintenance via telomerase
biol
ogic
ACD
al_p
roce
2.69
452
649
9
G
O:
00
01
88
0
G
O:
00
44
08
8
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
21
1
G
O:
20
00
07
4
G
O:
00
48
73
3
G
O:
00
02
09
7
G
O:
00
97
12
0
ss
regulation of type B pancreatic cell
development
biol
ogic
al_p GSK3A
roce
ss
2.69
452
649
9
sebaceous gland development
biol
ogic
al_p SMAD4
roce
ss
2.69
452
649
9
tRNA wobble base modification
biol
ogic
al_p MTO1
roce
ss
2.69
452
649
9
receptor localization to synapse
biol
ogic
al_p CEP112
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
71
78
6
G
O:
00
71
67
0
G
O:
00
90
20
9
G
O:
00
55
12
9
G
O:
00
02
endoplasmic reticulum tubular network
organization
biol
ogic
al_p RAB10
roce
ss
2.69
452
649
9
smooth muscle cell chemotaxis
biol
ogic
al_p PDGFRB
roce
ss
2.69
452
649
9
negative regulation of triglyceride metabolic
process
biol
ogic
al_p FBXW7
roce
ss
2.69
452
649
9
L-proline biosynthetic process
biol
ogic
al_p ALDH18A1
roce
ss
2.69
452
649
9
regulation of cellular extravasation
biol
ogic
ADAM8
al_p
roce
2.69
452
649
9
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
69
1
G
O:
00
09
20
2
G
O:
00
19
07
6
G
O:
00
07
19
5
G
O:
00
08
29
8
ss
deoxyribonucleoside triphosphate
biosynthetic process
biol
ogic
al_p DTYMK
roce
ss
2.69
452
649
9
viral release from host cell
biol
ogic
al_p TSG101
roce
ss
2.69
452
649
9
adenylate cyclase-inhibiting dopamine
receptor signaling pathway
biol
ogic
al_p FLNA
roce
ss
2.69
452
649
9
intracellular mRNA localization
biol
ogic
al_p BICD1
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
60
02
4
rhythmic synaptic transmission
biol
ogic
al_p PTEN
roce
ss
2.69
452
649
9
hepatocyte growth factor receptor signaling
pathway
biol
ogic
al_p NRP1
roce
ss
2.69
452
649
9
liver morphogenesis
biol
ogic
al_p FBXW7
roce
ss
2.69
452
649
9
G
O:
00
60
45
2
positive regulation of cardiac muscle
contraction
biol
ogic
al_p RGS2
roce
ss
2.69
452
649
9
G
O:
00
40
negative regulation of translation, ncRNAmediated
biol
ogic
TNRC6A
al_p
roce
2.69
452
649
9
G
O:
00
48
01
2
G
O:
00
72
57
6
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
03
3
G
O:
00
07
10
0
G
O:
00
34
20
1
G
O:
00
43
98
5
G
O:
00
48
85
9
ss
mitotic centrosome separation
biol
ogic
al_p RANBP1
roce
ss
2.69
452
649
9
response to oleic acid
biol
ogic
al_p AACS
roce
ss
2.69
452
649
9
histone H4-R3 methylation
biol
ogic
al_p PRMT5
roce
ss
2.69
452
649
9
formation of anatomical boundary
biol
ogic
al_p SMAD4
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
34
35
0
regulation of glial cell apoptotic process
biol
ogic
al_p PRKCH
roce
ss
2.69
452
649
9
metanephric distal convoluted tubule
development
biol
ogic
al_p PAX8
roce
ss
2.69
452
649
9
maintenance of DNA methylation
biol
ogic
al_p USP7
roce
ss
2.69
452
649
9
G
O:
00
61
00
0
negative regulation of dendritic spine
development
biol
ogic
al_p PTEN
roce
ss
2.69
452
649
9
G
O:
20
00
positive regulation of Wnt receptor signaling
pathway, planar cell polarity pathway
biol
ogic
ANKRD6
al_p
roce
2.69
452
649
9
G
O:
00
72
22
1
G
O:
00
10
21
6
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
09
6
G
O:
00
02
09
8
ss
tRNA wobble uridine modification
biol
ogic
al_p MTO1
roce
ss
2.69
452
649
9
dosage compensation by inactivation of X
chromosome
biol
ogic
al_p UPF1
roce
ss
2.69
452
649
9
G
O:
00
34
35
1
negative regulation of glial cell apoptotic
process
biol
ogic
al_p PRKCH
roce
ss
2.69
452
649
9
G
O:
00
90
08
0
positive regulation of MAPKKK cascade by
fibroblast growth factor receptor signaling
pathway
biol
ogic
al_p FGFR1
roce
ss
2.69
452
649
9
G
O:
00
09
04
8
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
48
49
6
G
O:
00
72
57
5
G
O:
00
30
95
2
G
O:
00
00
10
1
G
O:
00
06
maintenance of organ identity
biol
ogic
al_p NPHP3
roce
ss
2.69
452
649
9
epithelial cell proliferation involved in liver
morphogenesis
biol
ogic
al_p FBXW7
roce
ss
2.69
452
649
9
establishment or maintenance of
cytoskeleton polarity
biol
ogic
al_p LMNA
roce
ss
2.69
452
649
9
sulfur amino acid transport
biol
ogic
al_p CTNS
roce
ss
2.69
452
649
9
GMP biosynthetic process
biol
ogic
IMPDH1
al_p
roce
2.69
452
649
9
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
17
7
G
O:
00
45
97
4
G
O:
00
52
25
5
G
O:
19
01
72
3
G
O:
00
45
07
7
ss
regulation of translation, ncRNA-mediated
biol
ogic
al_p TNRC6A
roce
ss
2.69
452
649
9
modulation by organism of defense
response of other organism involved in
symbiotic interaction
biol
ogic
al_p SLC25A6
roce
ss
2.69
452
649
9
negative regulation of cell proliferation
involved in kidney development
biol
ogic
al_p FLCN
roce
ss
2.69
452
649
9
negative regulation of interferon-gamma
biosynthetic process
biol
ogic
al_p CD276
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
02
43
1
Fc receptor mediated stimulatory signaling
pathway
biol
ogic
al_p CSK
roce
ss
2.69
452
649
9
multicellular organismal iron ion
homeostasis
biol
ogic
al_p SLC11A2
roce
ss
2.69
452
649
9
sperm chromatin condensation
biol
ogic
al_p SRPK1
roce
ss
2.69
452
649
9
G
O:
00
35
35
6
cellular triglyceride homeostasis
biol
ogic
al_p C1QTNF3
roce
ss
2.69
452
649
9
G
O:
00
70
proton-transporting two-sector ATPase
complex assembly
biol
ogic
ATPAF2
al_p
roce
2.69
452
649
9
G
O:
00
60
58
6
G
O:
00
35
09
2
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
07
1
G
O:
00
14
03
4
G
O:
00
07
38
6
G
O:
00
32
26
2
G
O:
00
70
86
1
ss
neural crest cell fate commitment
biol
ogic
al_p FOXC1
roce
ss
2.69
452
649
9
compartment pattern specification
biol
ogic
al_p PBX3
roce
ss
2.69
452
649
9
pyrimidine nucleotide salvage
biol
ogic
al_p UCK1
roce
ss
2.69
452
649
9
regulation of protein exit from endoplasmic
reticulum
biol
ogic
al_p GCC2
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
33
15
3
G
O:
00
46
59
7
G
O:
00
10
83
9
G
O:
00
22
61
4
G
O:
00
31
T cell receptor V(D)J recombination
biol
ogic
al_p LEF1
roce
ss
2.69
452
649
9
negative regulation of viral entry into host
cell
biol
ogic
al_p IFITM3
roce
ss
2.69
452
649
9
negative regulation of keratinocyte
proliferation
biol
ogic
al_p PTPRK
roce
ss
2.69
452
649
9
membrane to membrane docking
biol
ogic
al_p EZR
roce
ss
2.69
452
649
9
negative regulation of cell killing
biol
ogic
PTPRC
al_p
roce
2.69
452
649
9
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
34
2
G
O:
00
35
79
1
G
O:
00
18
09
5
G
O:
00
51
01
3
G
O:
00
33
12
9
ss
platelet-derived growth factor receptor-beta
signaling pathway
biol
ogic
al_p PDGFRB
roce
ss
2.69
452
649
9
protein polyglutamylation
biol
ogic
al_p TTLL11
roce
ss
2.69
452
649
9
microtubule severing
biol
ogic
al_p TTLL11
roce
ss
2.69
452
649
9
positive regulation of histone
phosphorylation
biol
ogic
al_p RPS6KA5
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
21
93
2
hindbrain radial glia guided cell migration
biol
ogic
al_p LEF1
roce
ss
2.69
452
649
9
cardiac cell fate specification
biol
ogic
al_p TENM4
roce
ss
2.69
452
649
9
positive regulation of monocyte
differentiation
biol
ogic
al_p ACIN1
roce
ss
2.69
452
649
9
G
O:
00
71
48
1
cellular response to X-ray
biol
ogic
al_p NIPBL
roce
ss
2.69
452
649
9
G
O:
19
00
regulation of endoplasmic reticulum
unfolded protein response
biol
ogic
XBP1
al_p
roce
2.69
452
649
9
G
O:
00
60
91
2
G
O:
00
45
65
7
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
10
1
G
O:
20
00
82
2
G
O:
00
44
20
6
G
O:
00
02
31
8
G
O:
00
34
77
0
ss
regulation of behavioral fear response
biol
ogic
al_p MEF2A
roce
ss
2.69
452
649
9
UMP salvage
biol
ogic
al_p UCK1
roce
ss
2.69
452
649
9
myeloid progenitor cell differentiation
biol
ogic
al_p RUNX1
roce
ss
2.69
452
649
9
histone H4-K20 methylation
biol
ogic
al_p BAZ2A
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
72
10
4
glomerular capillary formation
biol
ogic
al_p PDGFRB
roce
ss
2.69
452
649
9
positive regulation by symbiont of host
defense response
biol
ogic
al_p SLC25A6
roce
ss
2.69
452
649
9
negative regulation of interleukin-5
production
biol
ogic
al_p LEF1
roce
ss
2.69
452
649
9
G
O:
00
21
91
0
smoothened signaling pathway involved in
ventral spinal cord patterning
biol
ogic
al_p GLI3
roce
ss
2.69
452
649
9
G
O:
00
35
determination of pancreatic left/right
asymmetry
biol
ogic
NPHP3
al_p
roce
2.69
452
649
9
G
O:
00
52
50
9
G
O:
00
32
71
4
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
46
9
G
O:
00
33
23
9
G
O:
00
51
96
4
G
O:
00
19
56
3
G
O:
00
09
21
1
ss
negative regulation of cellular amine
metabolic process
biol
ogic
al_p LPCAT1
roce
ss
2.69
452
649
9
negative regulation of synapse assembly
biol
ogic
al_p ROBO2
roce
ss
2.69
452
649
9
glycerol catabolic process
biol
ogic
al_p GK5
roce
ss
2.69
452
649
9
pyrimidine deoxyribonucleoside
triphosphate metabolic process
biol
ogic
al_p DTYMK
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
34
14
5
G
O:
00
60
12
0
G
O:
00
60
20
6
G
O:
00
72
02
5
G
O:
00
97
positive regulation of toll-like receptor 4
signaling pathway
biol
ogic
al_p NR1H3
roce
ss
2.69
452
649
9
inner ear receptor cell fate commitment
biol
ogic
al_p JAG2
roce
ss
2.69
452
649
9
estrous cycle phase
biol
ogic
al_p NCOR2
roce
ss
2.69
452
649
9
distal convoluted tubule development
biol
ogic
al_p PAX8
roce
ss
2.69
452
649
9
postsynaptic density protein 95 clustering
biol
ogic
NLGN2
al_p
roce
2.69
452
649
9
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
11
9
G
O:
00
32
85
4
G
O:
00
72
10
3
G
O:
00
10
63
3
G
O:
00
21
79
8
ss
positive regulation of Rap GTPase activity
biol
ogic
al_p SIPA1L1
roce
ss
2.69
452
649
9
glomerulus vasculature morphogenesis
biol
ogic
al_p PDGFRB
roce
ss
2.69
452
649
9
negative regulation of epithelial cell
migration
biol
ogic
al_p TGFBR3
roce
ss
2.69
452
649
9
forebrain dorsal/ventral pattern formation
biol
ogic
al_p GLI3
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
35
27
8
G
O:
00
60
66
5
G
O:
00
01
91
1
G
O:
00
71
02
5
G
O:
00
32
negative regulation of translation involved in
gene silencing by miRNA
biol
ogic
al_p TNRC6A
roce
ss
2.69
452
649
9
regulation of branching involved in salivary
gland morphogenesis by mesenchymalepithelial signaling
biol
ogic
al_p FGFR1
roce
ss
2.69
452
649
9
negative regulation of leukocyte mediated
cytotoxicity
biol
ogic
al_p PTPRC
roce
ss
2.69
452
649
9
RNA surveillance
biol
ogic
al_p XRN1
roce
ss
2.69
452
649
9
telomere assembly
biol
ogic
ACD
al_p
roce
2.69
452
649
9
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
20
2
G
O:
00
01
86
6
G
O:
00
07
03
5
G
O:
00
32
06
0
G
O:
00
19
36
7
ss
NK T cell proliferation
biol
ogic
al_p IL18
roce
ss
2.69
452
649
9
vacuolar acidification
biol
ogic
al_p CLIC4
roce
ss
2.69
452
649
9
bleb assembly
biol
ogic
al_p MYLK
roce
ss
2.69
452
649
9
fatty acid elongation, saturated fatty acid
biol
ogic
al_p ELOVL1
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
60
66
6
G
O:
00
52
51
0
G
O:
19
00
02
6
G
O:
00
70
93
4
G
O:
00
60
dichotomous subdivision of terminal units
involved in salivary gland branching
biol
ogic
al_p NRP1
roce
ss
2.69
452
649
9
positive regulation by organism of defense
response of other organism involved in
symbiotic interaction
biol
ogic
al_p SLC25A6
roce
ss
2.69
452
649
9
positive regulation of substrate adhesiondependent cell spreading
biol
ogic
al_p ARPC2
roce
ss
2.69
452
649
9
CRD-mediated mRNA stabilization
biol
ogic
al_p DHX9
roce
ss
2.69
452
649
9
regulation of gastric acid secretion
biol
ogic
SGK1
al_p
roce
2.69
452
649
9
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
45
3
G
O:
00
61
00
3
G
O:
00
00
38
9
G
O:
00
72
57
4
G
O:
00
01
30
2
ss
positive regulation of dendritic spine
morphogenesis
biol
ogic
al_p CAPRIN1
roce
ss
2.69
452
649
9
mRNA 3-splice site recognition
biol
ogic
al_p SF3A2
roce
ss
2.69
452
649
9
hepatocyte proliferation
biol
ogic
al_p FBXW7
roce
ss
2.69
452
649
9
replicative cell aging
biol
ogic
al_p ERCC1
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
42
11
8
endothelial cell activation
biol
ogic
al_p PRMT5
roce
ss
2.69
452
649
9
regulation of metanephric nephron tubule
epithelial cell differentiation
biol
ogic
al_p PAX8
roce
ss
2.69
452
649
9
mast cell cytokine production
biol
ogic
al_p BCL6
roce
ss
2.69
452
649
9
G
O:
00
97
10
4
postsynaptic membrane assembly
biol
ogic
al_p NLGN2
roce
ss
2.69
452
649
9
G
O:
00
35
cell migration involved in kidney
development
biol
ogic
PDGFRB
al_p
roce
2.69
452
649
9
G
O:
00
72
30
7
G
O:
00
32
76
2
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
78
7
G
O:
00
51
97
3
G
O:
00
32
71
3
G
O:
00
16
23
3
G
O:
00
19
36
8
ss
positive regulation of telomerase activity
biol
ogic
al_p ACD
roce
ss
2.69
452
649
9
negative regulation of interleukin-4
production
biol
ogic
al_p LEF1
roce
ss
2.69
452
649
9
telomere capping
biol
ogic
al_p ACD
roce
ss
2.69
452
649
9
fatty acid elongation, unsaturated fatty acid
biol
ogic
al_p ELOVL1
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
90
03
1
positive regulation of steroid hormone
biosynthetic process
biol
ogic
al_p IGF1R
roce
ss
2.69
452
649
9
ribonucleoprotein complex disassembly
biol
ogic
al_p KLC1
roce
ss
2.69
452
649
9
modulation by symbiont of host defense
response
biol
ogic
al_p SLC25A6
roce
ss
2.69
452
649
9
G
O:
00
48
53
9
bone marrow development
biol
ogic
al_p PTPRC
roce
ss
2.69
452
649
9
G
O:
00
46
negative regulation of alpha-beta T cell
proliferation
biol
ogic
TNFRSF14
al_p
roce
2.69
452
649
9
G
O:
00
32
98
8
G
O:
00
52
03
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
64
2
G
O:
00
09
91
2
G
O:
00
70
84
2
G
O:
20
00
97
3
G
O:
00
02
68
1
ss
auditory receptor cell fate commitment
biol
ogic
al_p JAG2
roce
ss
2.69
452
649
9
aggresome assembly
biol
ogic
al_p HDAC6
roce
ss
2.69
452
649
9
regulation of pro-B cell differentiation
biol
ogic
al_p FLCN
roce
ss
2.69
452
649
9
somatic recombination of T cell receptor
gene segments
biol
ogic
al_p LEF1
roce
ss
2.69
452
649
9
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
G
O:
00
45
76
4
G
O:
00
35
46
1
G
O:
00
51
09
6
G
O:
00
30
97
0
G
O:
00
90
positive regulation of cellular amino acid
metabolic process
biol
ogic
al_p PAX8
roce
ss
2.69
452
649
9
vitamin transmembrane transport
biol
ogic
al_p SLC23A2
roce
ss
2.69
452
649
9
positive regulation of helicase activity
biol
ogic
al_p SSBP1
roce
ss
2.69
452
649
9
retrograde protein transport, ER to cytosol
biol
ogic
al_p DERL2
roce
ss
2.69
452
649
9
regulation of inclusion body assembly
biol
ogic
SNCAIP
al_p
roce
2.69
452
649
9
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
3.
2
0
E
08
3
G
O:
00
32
05
7
G
O:
00
42
25
3
G
O:
00
65
00
3
G
O:
00
50
87
ss
negative regulation of translational initiation
in response to stress
biol
ogic
al_p EIF2B4
roce
ss
2.69
452
649
9
granulocyte macrophage colony-stimulating
factor biosynthetic process
biol
ogic
al_p IL18
roce
ss
2.69
452
649
9
macromolecular complex assembly
regulation of body fluid levels
CRBN,IGF1R,RAF1,SFSWAP,TAZ,SART1,SHMT2,GPAA1,CLNS1A,NU
P98,HDAC6,ARPC4TTLL3,GLS,BCL2L11,COG4,PAM,DDX23,CAPZB,ACTR3,VASP,NOD1,
biol
TTC19,DNM1L,RC3H1,PPP5C,BCLAF1,HSF4,DISP1,CELF1,SF3A2,SH
ogic
ARPIN,MDM2,FKBP1A,MAGI1,PIH1D1,ADSL,MITF,RB1,PRMT5,PUM2,
al_p
ARPC2,DDX6,BICD1,PXN,FECH,ERAL1,WASH4P,VILL,TRIM28,TBCD,
roce
TSPAN4,COX14,ZNF148,GOPC,RANBP9,ATPAF2,NCK2,TCF4,ACTR2,
ss
SRSF10,SMAD4,C1QTNF3,CENPT,HGSNAT,BCS1L,TMED2,CIRBP,NC
BP2,TGS1,KCTD2,SNRPE,TWF1,AMFR,KCTD17,TFAM,SHPRH,HBB,T
GFBR3,UQCRH,SENP6,FMOD,SMARCAD1
biol FZD6,PPIL2,RAF1,GP1BB,F11R,SLC16A3,ATP2B1,CBX5,DGKA,CAPZ
ogic B,CD9,PTPN6,PRKACA,APLNR,SLC16A1,JAM2,HPS4,PRKCH,CREB1,
al_p LCP2,NPR1,ITGA3,GNAI1,ZFPM2,ESAM,ANXA5,NR1H3,FAP,FYN,CSK
roce ,VPS45,DGKZ,KLC1,FLNA,RAB5A,ITGA5,RAD51B,RAP1B,TLN1,DOCK
ss
8,NCOR2,PHF21A,HBB,PDPK1,USF1,CD63,WNK1,GATA2
0
1
3.
2
0
E
0
1
3.
2
0
E
0
1
1.05
415
635
9
3.
2
1
E
0
1
1.07
422
983
3
3.
2
2
E
-
8
G
O:
00
07
62
6
locomotory behavior
biol
ogic
NPC1,CNP,CLN8,GIGYF2,PAFAH1B1,HEXA,PTEN,CTNS,PBX3,GAA,T
al_p
BCE,FGF14,NLGN2
roce
ss
1.16
762
814
9
membrane coat
cell
ular
_co AP3S2,SEC31A,AP4B1,EPN2,CLTCL1,CLTB,TMED3
mpo
nent
1.25
581
146
7
coated membrane
cell
ular
_co AP3S2,SEC31A,AP4B1,EPN2,CLTCL1,CLTB,TMED3
mpo
nent
1.25
581
146
7
G
O:
00
03
95
0
NAD+ ADP-ribosyltransferase activity
mol
ecul
ar_f
unct
ion
SIRT2,PARP6,SIRT3
1.50
075
142
8
G
O:
T-tubule
cell
ular
CAMK2D,CACNB1,CACNA2D1
1.49
928
G
O:
00
30
11
7
G
O:
00
48
47
5
0
1
3.
2
2
E
0
1
3.
2
3
E
0
1
3.
2
3
E
0
1
3.
2
3
E
0
1
3.
2
00
30
31
5
G
O:
00
45
91
2
G
O:
00
06
65
6
G
O:
00
31
05
7
G
O:
00
30
85
1
_co
mpo
nent
511
9
negative regulation of carbohydrate
metabolic process
biol
ogic
al_p GRB10,C1QTNF3,GSK3A
roce
ss
1.49
695
916
6
phosphatidylcholine biosynthetic process
biol
ogic
al_p CHKB,LPCAT1,PCYT1A
roce
ss
1.49
695
916
6
negative regulation of histone modification
biol
ogic
al_p NOC2L,PHF1,UBR5
roce
ss
1.49
695
916
6
granulocyte differentiation
biol
ogic
al_p LEF1,RUNX1,GATA2
roce
ss
1.49
695
916
6
3
E
0
1
3.
2
4
E
0
1
3.
2
4
E
0
1
3.
2
4
E
0
1
3.
2
4
E
0
1
G
O:
00
48
59
6
embryonic camera-type eye morphogenesis
biol
ogic
al_p TBX2,ZEB1,ALDH1A3
roce
ss
1.49
695
916
6
synaptic transmission, GABAergic
biol
ogic
al_p NISCH,NF1,NLGN2
roce
ss
1.49
695
916
6
2-deoxyribonucleotide metabolic process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
1.49
695
916
6
G
O:
00
08
33
3
endosome to lysosome transport
biol
ogic
al_p HGS,VAMP7,SNX27
roce
ss
1.49
695
916
6
G
O:
positive regulation of DNA repair
biol
ogic
1.49
695
G
O:
00
51
93
2
G
O:
00
09
39
4
RNF8,RNF168,TRIM28
3.
2
4
E
0
1
3.
2
4
E
0
1
3.
2
4
E
0
1
3.
2
4
E
0
1
3.
2
00
45
73
9
G
O:
00
01
55
8
G
O:
00
19
07
9
G
O:
00
10
86
3
G
O:
00
30
52
1
al_p
roce
ss
916
6
regulation of cell growth
biol
ogic BCL6,DERL2,LEF1,USP47,CSNK2A1,CAMK2D,TRO,SGK1,TCHP,INO8
al_p 0,NPR1,NOL8,LTBP4,PAFAH1B1,FLCN,NRP1,IGFBP6,N6AMT1,SEMA4
roce D,SMAD4,CDK11A,SMARCA4,GSK3A,TSG101
ss
1.11
114
494
8
viral genome replication
biol
ogic
al_p SUPT5H,VAPB,RAD23A,IFITM3,SRPK1,UBP1
roce
ss
1.28
310
785
7
positive regulation of phospholipase C
activity
biol
ogic
al_p PRKACA,FGFR1,ADCY4,CREB1,PDGFRB,NTRK1
roce
ss
1.28
310
785
7
androgen receptor signaling pathway
biol
ogic
al_p HDAC6,RB1,PIAS2,TGFB1I1,SMARCA4,PPAP2A
roce
ss
1.28
310
785
7
4
E
0
1
3.
2
5
E
0
1
3.
2
5
E
0
1
3.
2
5
E
0
1
3.
2
5
E
0
1
G
O:
00
05
09
9
Ras GTPase activator activity
mol
ecul
ar_f
unct
ion
response to radiation
biol
ogic NOC2L,PNKP,USP47,ASNS,RNF8,MDM2,RHBDD1,YY1,INO80,PTPRK,
al_p NF1,CRIP1,NIPBL,RNF168,IL18,FBXW7,CTNS,FECH,MAPK8,PTPRC,N
roce OX4,ERCC1,CIRBP,TANC1,NTRK1,USF1
ss
1.10
501
086
7
acetylglucosaminyltransferase activity
mol
ecul
ar_f
unct
ion
XYLT1,GCNT2,MGAT5,EXT1
1.38
530
901
G
O:
00
08
40
8
3-5 exonuclease activity
mol
ecul
ar_f
unct
ion
DIS3L,PAN2,PARN,REXO2
1.38
530
901
G
O:
germ cell development
biol
ogic
PRKACA,SEPT4,CELF1,RNF8,PAFAH1B1,PLD6,SRPK1,AFF4,GOPC,E
RCC1,DZIP1,ZBTB16
1.17
153
G
O:
00
09
31
4
G
O:
00
08
37
5
RALGAPA2,TBC1D2B,TBC1D10B,TBC1D14,NF1,IQGAP1,SRGAP2,AR
HGAP29,SGSM3,TBC1D22A
1.19
528
874
8
3.
2
6
E
0
1
3.
2
6
E
0
1
3.
2
6
E
0
1
3.
2
6
E
0
1
3.
2
00
07
28
1
G
O:
00
00
08
4
G
O:
00
04
70
2
G
O:
00
50
70
9
G
O:
00
51
49
2
al_p
roce
ss
326
S phase of mitotic cell cycle
biol
ogic
PSMB10,BCL6,PSMB9,GIGYF2,PAF1,RB1,CHMP1A,CUL4A,PSMC6,PS
al_p
MC4,SMARCA4,PSMA1
roce
ss
1.17
153
326
receptor signaling protein serine/threonine
kinase activity
mol
ecul
ar_f
unct
ion
1.10
176
011
2
negative regulation of protein secretion
biol
ogic
al_p RHBDF1,NR1H3,C1QTNF3,RHBDF2
roce
ss
1.38
180
846
1
regulation of stress fiber assembly
biol
ogic
al_p PPM1F,PAK1,FHOD1,NOX4
roce
ss
1.38
180
846
1
IGF1R,RAF1,ZFP91,ADAM8,PTPN6,NOD1,FGFR1,TAB2,NF1,MAPK8IP
3,RGS3,PXN,MAPK8,CSK,PTPRC,PAK1,MAPK12,NOX4,MDFI,RGS2,P
DGFRB,CARD14,PDCD4,NTRK1,SPRED1,TNFRSF10B,DUSP6
7
E
0
1
3.
2
7
E
0
1
3.
2
8
E
0
1
3.
2
8
E
0
1
3.
2
8
E
0
1
G
O:
00
06
97
9
response to oxidative stress
biol
ogic HDAC6,VRK2,PNKP,SLC11A2,CLN8,MDM2,PTPRK,TPM4,PKD2,IL18,I
al_p DH1,PXN,ALDH3B1,SLC23A2,NDUFS2,ARNT,ERCC1,PDGFRB,DIABL
roce O,HBB,STK24
ss
1.11
828
174
8
myeloid cell differentiation
biol
ogic BCL6,LEF1,SLC11A2,PAF1,NF1,MITF,RB1,PAFAH1B1,NCOR1,MEF2A,
al_p FECH,CDK6,WDR61,CSF1R,ARNT,RUNX1,SMARCA4,ACIN1,TGFBR3,
roce ZBTB16,GATA2
ss
1.11
828
174
8
regulation of embryonic development
biol
ogic
al_p NPHP3,TBX2,TBX18,FGFR1,NIPBL,NR2C2,DUSP6,TENM4
roce
ss
1.22
478
477
2
G
O:
00
32
98
4
macromolecular complex disassembly
biol
ogic
HDAC6,CAPZB,UPF1,RPL27,RPL9,RPL24,RPL37A,SMARCD3,VILL,KL
al_p
C1,RPL4,MTRF1L,SMARCA4,RPLP0,TWF1,CLASP1
roce
ss
1.14
054
031
7
G
O:
positive regulation of gene expression
biol
ogic
1.04
905
G
O:
00
30
09
9
G
O:
00
45
99
5
PBX2,EPHX2,SUPT5H,FUBP1,MMS19,SMAD7,MCF2L,ZNF496,LEF1,P
AX8,SUPT4H1,GABPB1,IGBP1,PTGES2,ZC3H12A,BCLAF1,JHDM1D,W
3.
2
9
E
0
1
3.
2
9
E
0
1
3.
2
9
E
0
1
3.
2
9
E
0
1
3.
3
00
10
62
8
G
O:
00
16
81
0
al_p AC,FUBP3,HSF4,PAF1,MDM2,PPM1F,TBP,INO80,CREB1,DDX58,ZEB1
roce ,RGMB,EBF1,RPS6KA5,PKD2,RXRB,LMNA,MITF,RB1,ZFPM2,TP53BP
ss
1,SENP2,IL18,NR1H3,FLCN,RUNX2,FBXW7,SMARCD3,IKBKB,MEF2A,
PIAS2,MAPK8,DDX41,TRIM28,CDK5RAP2,CDK6,WDR61,ZNF148,NCK
2,CTSH,TCF4,NFYC,SS18,SMAD4,CHURC1,CHURC1FNTB,TGFB1I1,NR2C2,FHOD1,GLI3,TMED2,DCAF6,ENG,SIRT7,TCF1
2,ARNT,MED6,HINFP,GLIS3,RUNX1,SMARCA4,NAA16,STAT6,TFAM,S
MAD9,ZBTB16,PKD1,USF1,FOXC1,CDK5RAP3,SMARCAD1,GATA2
mol
ecul
hydrolase activity, acting on carbon-nitrogen
ar_f
(but not peptide) bonds
unct
ion
012
4
SIRT2,HDAC6,GLS,NADSYN1,NCOR1,MAPK8,DDAH1,SIRT7,NIT1,SIR
T3,DDAH2
1.17
916
183
6
cell-type specific apoptotic process
biol
ogic NOC2L,NLRP1,BDNF,BCL6,CNTF,LEF1,PAX8,BCL2L11,ADAM8,KRIT1,
al_p PRKCH,NF1,CASP2,RB1,IL18,PTEN,LGMN,MEF2A,GLI3,GAPDH,NRB
roce P2,NTRK1,PDPK1
ss
1.11
064
712
3
G
O:
00
35
23
9
tube morphogenesis
biol
ogic FZD6,NPHP3,TBX2,LEF1,PAX8,BCL2L11,VASP,SDCCAG8,STK4,PKD2
al_p ,NRP1,IFT172,PXN,MEF2A,TCTN1,PAK1,CTSH,CSF1R,SMAD4,GLI3,T
roce MED2,ENG,SETD2,CLIC4,PKD1,C2CD3
ss
1.10
153
599
G
O:
00
regulation of developmental process
biol
ogic
al_p
1.04
118
945
G
O:
00
97
28
5
FZD6,NPHP3,SIRT2,RAF1,BDNF,SART1,MARCH5,LUC7L,BCL6,TBX2,
CNTF,SMAD7,GLG1,RNH1,IL15RA,LEF1,PAX8,BCL2L11,MEPE,ADAM
8,CAPZB,PRPF40A,SIPA1L1,KRIT1,PDLIM5,PTPN6,ACTR3,PRKACA,D
0
E
0
1
3.
3
0
E
0
1
3.
3
0
E
0
1
3.
3
2
E
0
1
3.
3
2
50
79
3
G
O:
00
18
39
3
G
O:
00
00
98
0
G
O:
00
05
45
1
roce NM1L,RC3H1,ZC3H12A,TBX18,FGFR1,HPS4,HSF4,CAPRIN1,PAF1,PR
ss
KCH,SSH2,CREB1,NPTN,NF1,ZEB1,MED28,NPR1,NIPBL,LMNA,MITF,
RB1,LTBP4,ZFPM2,BLOC1S5,PAFAH1B1,IL18,ARPC2,NR1H3,FLCN,N
RP1,VPS72,PTEN,FYN,RUNX2,FBXW7,SMARCD3,SRGAP2,MEF2A,M
APK8,CDK5RAP2,PTPRC,CDK6,WDR61,STAG2,SEMA6A,CTSH,TCF4,
SEMA4D,CSF1R,C3,SMAD4,TGFB1I1,DDAH1,EZR,CD276,NR2C2,GLI3
,MAPK12,TCF12,ARNT,MED6,PTPRD,PDGFRB,RUNX1,SMARCA4,KIF
13B,GSK3A,ANKRD6,NLGN2,NCOR2,PTGIS,STAT6,ACIN1,ROBO2,PM
P22,CDK5RAP1,BNIP2,NTRK1,BRWD1,SMAD9,DUSP6,TGFBR3,ZBTB
16,STK24,SSH1,CDK5RAP3,TENM4,GATA2
3
internal peptidyl-lysine acetylation
biol
ogic
NOC2L,LEF1,DR1,PHF15,RPS6KA5,FLCN,ING4,MSL1,SMARCA4,KAN
al_p
SL3,GATA2
roce
ss
1.17
618
220
2
RNA polymerase II distal enhancer
sequence-specific DNA binding
mol
ecul
ar_f
unct
ion
CREB1,GATA2
1.68
834
535
6
monovalent cation:hydrogen antiporter
activity
mol
ecul
ar_f
unct
ion
SLC9A5,SLC9A8
1.68
834
535
6
E
0
1
3.
3
3
E
0
1
3.
3
4
E
0
1
3.
3
4
E
0
1
G
O:
00
35
25
1
G
O:
00
51
87
9
G
O:
00
16
78
0
G
O:
00
19
82
7
G
O:
00
06
UDP-glucosyltransferase activity
mol
ecul
ar_f
unct
ion
Hsp90 protein binding
mol
ecul
ar_f
unct
ion
phosphotransferase activity, for other
substituted phosphate groups
mol
ecul
ar_f
unct
ion
stem cell maintenance
biol
ogic
al_p PAX8,PAF1,MED28,NIPBL,VPS72,STAG2,MED6,SMARCA4,GATA2
roce
ss
1.20
053
160
8
vitamin metabolic process
biol
ogic
PNPO,PDXK,NADSYN1,NADK,CYP2R1,LGMN,SLC23A2,FPGS,GPHN
al_p
roce
1.20
053
160
8
GSK3A,IGF2
1.68
834
535
6
HDAC6,CSNK2A1
1.68
834
535
6
PGS1,PIGG
1.68
834
535
6
3.
3
4
E
0
1
3.
3
4
E
0
1
3.
3
4
E
0
1
3.
3
5
E
0
1
3.
3
5
E
76
6
G
O:
00
03
20
3
G
O:
00
33
96
2
G
O:
00
72
01
0
G
O:
00
97
03
1
ss
endocardial cushion morphogenesis
biol
ogic
al_p TBX2,ENG
roce
ss
1.68
407
906
2
cytoplasmic mRNA processing body
assembly
biol
ogic
al_p RC3H1,DDX6
roce
ss
1.68
407
906
2
glomerular epithelium development
biol
ogic
al_p IQGAP1,MYO1E
roce
ss
1.68
407
906
2
mitochondrial respiratory chain complex I
biogenesis
biol
ogic
al_p TAZ,BCS1L
roce
ss
1.68
407
906
2
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
G
O:
00
32
10
8
G
O:
00
71
77
3
G
O:
00
32
10
5
G
O:
00
72
31
1
G
O:
00
31
negative regulation of response to nutrient
levels
biol
ogic
al_p NPC1,NRBP2
roce
ss
1.68
407
906
2
cellular response to BMP stimulus
biol
ogic
al_p COL2A1,RUNX2
roce
ss
1.68
407
906
2
negative regulation of response to
extracellular stimulus
biol
ogic
al_p NPC1,NRBP2
roce
ss
1.68
407
906
2
glomerular epithelial cell differentiation
biol
ogic
al_p IQGAP1,MYO1E
roce
ss
1.68
407
906
2
chromatin disassembly
biol
ogic
SMARCD3,SMARCA4
al_p
roce
1.68
407
906
2
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
49
8
G
O:
00
90
11
4
G
O:
00
32
98
6
G
O:
00
06
33
7
G
O:
00
42
55
9
ss
COPII-coated vesicle budding
biol
ogic
al_p SEC31A,TMED2
roce
ss
1.68
407
906
2
protein-DNA complex disassembly
biol
ogic
al_p SMARCD3,SMARCA4
roce
ss
1.68
407
906
2
nucleosome disassembly
biol
ogic
al_p SMARCD3,SMARCA4
roce
ss
1.68
407
906
2
pteridine-containing compound biosynthetic
process
biol
ogic
al_p PTS,FPGS
roce
ss
1.68
407
906
2
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
G
O:
00
51
56
7
histone H3-K9 methylation
biol
ogic
al_p EHMT1,BAZ2A
roce
ss
1.68
407
906
2
extrinsic apoptotic signaling pathway via
death domain receptors
biol
ogic
al_p DIABLO,TNFRSF10B
roce
ss
1.68
407
906
2
mitochondrial respiratory chain complex I
assembly
biol
ogic
al_p TAZ,BCS1L
roce
ss
1.68
407
906
2
G
O:
00
72
49
8
embryonic skeletal joint development
biol
ogic
al_p COL2A1,EXT1
roce
ss
1.68
407
906
2
G
O:
00
51
positive regulation of synaptic transmission,
glutamatergic
biol
ogic
NLGN2,NTRK1
al_p
roce
1.68
407
906
2
G
O:
00
08
62
5
G
O:
00
32
98
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
96
8
G
O:
00
33
11
9
G
O:
00
45
74
5
G
O:
00
10
95
5
G
O:
00
02
06
3
ss
negative regulation of RNA splicing
biol
ogic
al_p SFSWAP,SRSF10
roce
ss
1.68
407
906
2
positive regulation of G-protein coupled
receptor protein signaling pathway
biol
ogic
al_p C3,GSK3A
roce
ss
1.68
407
906
2
negative regulation of protein processing
biol
ogic
al_p GLG1,MDM2
roce
ss
1.68
407
906
2
chondrocyte development
biol
ogic
al_p RUNX2,ACAN
roce
ss
1.68
407
906
2
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
G
O:
00
45
83
8
G
O:
00
09
08
6
G
O:
00
06
82
5
G
O:
00
10
92
2
G
O:
00
71
positive regulation of membrane potential
biol
ogic
al_p PTEN,NLGN2
roce
ss
1.68
407
906
2
methionine biosynthetic process
biol
ogic
al_p EIF2B4,MTRR
roce
ss
1.68
407
906
2
copper ion transport
biol
ogic
al_p SLC11A2,CP
roce
ss
1.68
407
906
2
positive regulation of phosphatase activity
biol
ogic
al_p MEF2A,PDGFRB
roce
ss
1.68
407
906
2
response to BMP stimulus
biol
ogic
COL2A1,RUNX2
al_p
roce
1.68
407
906
2
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
77
2
G
O:
00
10
25
7
G
O:
00
45
94
7
G
O:
00
45
74
6
G
O:
00
01
71
1
ss
NADH dehydrogenase complex assembly
biol
ogic
al_p TAZ,BCS1L
roce
ss
1.68
407
906
2
negative regulation of translational initiation
biol
ogic
al_p EIF2B4,FMR1
roce
ss
1.68
407
906
2
negative regulation of Notch signaling
pathway
biol
ogic
al_p FBXW7,GATA2
roce
ss
1.68
407
906
2
endodermal cell fate commitment
biol
ogic
al_p PAF1,DUSP6
roce
ss
1.68
407
906
2
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
G
O:
00
38
08
4
G
O:
00
03
21
5
G
O:
00
55
00
3
G
O:
00
35
10
7
G
O:
00
35
vascular endothelial growth factor signaling
pathway
biol
ogic
al_p NRP1,PDGFRB
roce
ss
1.68
407
906
2
cardiac right ventricle morphogenesis
biol
ogic
al_p ZFPM2,SMARCD3
roce
ss
1.68
407
906
2
cardiac myofibril assembly
biol
ogic
al_p MEF2A,PDGFRB
roce
ss
1.68
407
906
2
appendage morphogenesis
biol
ogic
PBX2,COL2A1,TBX2,LEF1,FGFR1,NIPBL,ACD,LMBR1,GLI3,SMARCA4,
al_p
ZBTB16,C2CD3
roce
ss
1.16
310
496
3
limb morphogenesis
biol
ogic PBX2,COL2A1,TBX2,LEF1,FGFR1,NIPBL,ACD,LMBR1,GLI3,SMARCA4,
al_p ZBTB16,C2CD3
roce
1.16
310
496
3
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
5
E
0
1
3.
3
6
E
0
1
3.
3
6
E
10
8
G
O:
00
07
56
8
G
O:
00
07
17
8
G
O:
00
44
25
9
G
O:
00
43
24
4
ss
aging
biol
ogic
MARCH5,TBX2,CNP,CLN8,PDE4D,CASP2,LMNA,PTEN,CDK6,ENG,NO
al_p
X4,ERCC1,CANX,POLG,PDCD4,NTRK1
roce
ss
1.13
453
747
3
transmembrane receptor protein
serine/threonine kinase signaling pathway
biol
ogic F11R,SMAD7,GLG1,LEF1,RBPMS,FKBP1A,PTPRK,ZEB1,RGMB,LTBP
al_p 4,FLCN,RUNX2,NCOR1,USP15,SMAD4,TGFB1I1,ENG,PDGFRB,NCOR
roce 2,SMAD9,TGFBR3,PDPK1,FMOD
ss
1.10
668
052
6
multicellular organismal macromolecule
metabolic process
biol
ogic
al_p MMP16,SERPINH1,IL18,ADAM15,TENC1,PDGFRB
roce
ss
1.26
305
929
6
regulation of protein complex disassembly
biol
ogic
al_p HDAC6,CAPZB,UPF1,VILL,TWF1,CLASP1
roce
ss
1.26
305
929
6
0
1
3.
3
7
E
0
1
3.
3
7
E
0
1
3.
3
8
E
0
1
3.
3
8
E
0
1
G
O:
00
09
10
0
G
O:
00
19
08
3
G
O:
00
19
08
0
G
O:
00
09
41
6
G
O:
00
42
glycoprotein metabolic process
biol
ogic
al_p
roce
ss
viral transcription
biol
ogic
SUPT5H,LEF1,SUPT4H1,RPL27,IFITM3,RPL9,RPL24,RPL37A,RPL4,N
al_p
CBP2,SMARCA4,RPLP0,USF1
roce
ss
1.15
226
462
1
viral genome expression
biol
ogic
SUPT5H,LEF1,SUPT4H1,RPL27,IFITM3,RPL9,RPL24,RPL37A,RPL4,N
al_p
CBP2,SMARCA4,RPLP0,USF1
roce
ss
1.15
226
462
1
response to light stimulus
biol
ogic
NOC2L,USP47,ASNS,MDM2,RHBDD1,YY1,INO80,PTPRK,NF1,CRIP1,F
al_p
BXW7,CTNS,FECH,MAPK8,ERCC1,CIRBP,TANC1,USF1
roce
ss
1.12
271
937
4
ovulation cycle
biol
ogic
EIF2B4,ADAMTS1,PAM,CASP2,RUNX1,NCOR2,ROBO2,FOXC1
al_p
roce
1.21
102
314
5
SIRT2,COL2A1,ST3GAL1,XYLT1,NPC1,SEC31A,MCFD2,ALG6,ST3GAL
4,GCNT2,EDEM2,GALNT2,HEXA,UST,NECAB3,MAN1A2,ST6GALNAC
5,FUT4,MGAT5,B4GALT4,EXT1,B3GAT3,MAN2A2,MAN1B1,CANX,PDI
A3,LMF1,SIRT3,ACAN,ALG9
1.08
943
119
9
3.
3
9
E
0
1
3.
3
9
E
0
1
3.
3
9
E
0
1
3.
3
9
E
0
1
3.
4
0
E
69
8
G
O:
00
33
61
3
G
O:
00
16
05
1
G
O:
00
46
98
3
G
O:
00
30
66
7
ss
activating transcription factor binding
mol
ecul
ar_f
unct
ion
carbohydrate biosynthetic process
biol
ogic
MPDU1,PRKACA,ISYNA1,GRB10,SMEK1,ST6GALNAC5,PHKG2,C1QT
al_p
NF3,EXT1,GAPDH,GSK3A,IGF2,PGM2,PHKG1
roce
ss
CREB1,RB1,TP53BP1,NCOR1,MEF2A
CRBN,RAB3GAP2,CADM1,PTS,EPHX2,RALGAPA2,TARS,RAF1,SUPT
5H,DPP4,VAPB,SUPT4H1,BCL2L11,APITD1,GABPB1,NOD1,ASNS,PD
XK,NUP210,TBX18,DR1,JAM2,STK4,FGFR1,HPS4,RNF8,EBF1,PKD2,
MITF,MZF1,PAFAH1B1,CALCOCO2,SYNE1,GARS,HEXA,PLD6,FAP,AL
DH1A3,IDH1,SRGAP2,MEF2A,OXCT1,MYCBP2,EBF4,UBA2,GOPC,TC
F4,CSF1R,NFYC,P4HB,HSD17B4,ROBO3,SMAD4,GRPEL2,TBC1D22A,
CENPT,NR2C2,FLNA,SDCBP2,ENG,TCF12,ARNT,EXT1,MLX,RUNX1,S
UMF2,KLHL7,PCYT1A,ROBO2,NTRK1,ZBTB16,USF1,TENM4
protein dimerization activity
mol
ecul
ar_f
unct
ion
secretory granule membrane
cell
ular
_co PAM,ADAM8,CD9,TMED2,CD63
mpo
nent
1.29
872
719
7
1.14
313
245
4
0
1
3.
4
1
E
0
1
3.
4
1
E
0
1
1.05
116
597
9
3.
4
2
E
0
1
1.29
567
849
8
3.
4
2
E
0
1
G
O:
00
35
14
8
G
O:
00
32
10
2
G
O:
00
51
04
9
G
O:
00
60
99
3
tube formation
biol
ogic
FZD6,NPHP3,PAX8,BCL2L11,VASP,SDCCAG8,STK4,IFT172,TCTN1,T
al_p
MED2,SETD2
roce
ss
1.16
692
092
5
negative regulation of response to external
stimulus
biol
ogic
NPC1,SHARPIN,NR1H3,NRP1,PTEN,C1QTNF3,CD276,NRBP2,PTGIS,
al_p
PSMA1,ROBO2
roce
ss
1.16
692
092
5
regulation of transport
CRBN,CADM1,UTRN,NLRP1,SEPT5,RSC1A1,NUP98,SYTL4,PAX8,RB
PMS,PAM,UHMK1,ADAM8,MINK1,PRKACA,DNM1L,NUP210,VAMP7,C
AMK2D,TNK2,TPCN2,DISP1,SNCAIP,SGK1,MDM2,RHBDD1,FKBP1A,C
biol
REB1,DDX58,RHBDF1,NF1,NPR1,CAPN10,PKD2,AACS,BICD1,GCC2,
ogic
NR1H3,GRB10,NRP1,IQGAP1,PHPT1,IKBKB,SNX17,NCOR1,OXCT1,C
al_p
ACNB1,CLTCL1,MYLK,ABCA2,RAB8A,CSK,TMEM66,NUP37,AAK1,GO
roce
PC,CSF1R,C3,SMAD4,C1QTNF3,FLNA,RAB5A,GLI3,SCFD1,SLC25A6,
ss
VAMP4,MDFI,NUP85,NCBP2,PDGFRB,RAP1B,RUNX1,RHBDF2,FGF14
,GSK3A,NLGN2,CACNB3,CLIC4,CACNA2D1,CACNA2D4,SPCS3,SEPT
2,PKD1,PDPK1,KPNA1,CD63,UBR5,WNK1,GATA2
kidney morphogenesis
biol
ogic
al_p NPHP3,PAX8,PKD2,PDGFRB,PKD1
roce
ss
3.
4
2
E
0
1
3.
4
2
E
0
1
1.04
539
171
3.
4
2
E
0
1
1.29
544
543
2
3.
4
3
E
0
1
G
O:
00
10
82
1
G
O:
00
48
28
4
G
O:
00
04
54
0
G
O:
00
01
19
1
G
O:
00
70
regulation of mitochondrion organization
biol
ogic
al_p MARCH5,BCL2L11,DNM1L,FLCN,GOLPH3
roce
ss
1.29
544
543
2
organelle fusion
biol
ogic
al_p RAB34,VAMP7,GNAI1,PLD6,RAB8A
roce
ss
1.29
544
543
2
ribonuclease activity
mol
ecul
ar_f
unct
ion
RNH1,RPP14,RNASET2,DIS3L,PAN2,RNASEK,PARN
1.22
788
753
2
RNA polymerase II transcription factor
binding transcription factor activity involved
in negative regulation of transcription
mol
ecul
ar_f
unct
ion
HDGF,TBX18,PHF12
1.44
715
316
2
E-box binding
mol
ecul
ar_f
unct
ZEB1,TCF4,TCF12
1.44
715
316
2
3.
4
3
E
0
1
3.
4
3
E
0
1
3.
4
4
E
0
1
3.
4
4
E
0
1
3.
4
4
E
88
8
G
O:
00
48
70
5
G
O:
00
48
48
5
G
O:
00
30
83
5
G
O:
00
48
85
4
ion
skeletal system morphogenesis
biol
ogic
COL9A1,COL2A1,GLG1,FGFR1,THBS3,ZEB1,NIPBL,RUNX2,MEF2A,E
al_p
VC,GLI3,MDFI,PDGFRB,SETD2,COL13A1,ACAN
roce
ss
1.12
859
748
6
sympathetic nervous system development
biol
ogic
al_p NF1,NRP1,NTRK1
roce
ss
1.44
349
633
9
negative regulation of actin filament
depolymerization
biol
ogic
al_p CAPZB,VILL,TWF1
roce
ss
1.44
349
633
9
brain morphogenesis
biol
ogic
al_p NF1,PAFAH1B1,PTEN
roce
ss
1.44
349
633
9
0
1
3.
4
4
E
0
1
3.
4
5
E
0
1
3.
4
5
E
0
1
3.
4
5
E
0
1
G
O:
00
05
97
9
G
O:
00
10
96
2
G
O:
00
60
04
3
G
O:
00
60
67
4
G
O:
00
07
regulation of glycogen biosynthetic process
biol
ogic
al_p GRB10,GSK3A,IGF2
roce
ss
1.44
349
633
9
regulation of glucan biosynthetic process
biol
ogic
al_p GRB10,GSK3A,IGF2
roce
ss
1.44
349
633
9
regulation of cardiac muscle cell
proliferation
biol
ogic
al_p TBX2,FGFR1,MEF2A
roce
ss
1.44
349
633
9
placenta blood vessel development
biol
ogic
al_p PLCD1,PKD2,PKD1
roce
ss
1.44
349
633
9
gastrulation
biol
ogic NPHP3,SUPT20H,LEF1,PRKACA,FGFR1,PAF1,SMAD4,EXT1,DUSP6,F
al_p OXC1,EYA2,TENM4
roce
1.15
479
707
1
3.
4
5
E
0
1
3.
4
5
E
0
1
3.
4
5
E
0
1
3.
4
5
E
0
1
3.
4
5
E
36
9
G
O:
00
48
16
8
G
O:
00
10
67
6
G
O:
00
45
77
8
G
O:
00
42
13
0
ss
regulation of neuronal synaptic plasticity
biol
ogic
al_p BDNF,NPTN,NF1,RAB8A
roce
ss
1.34
726
324
9
positive regulation of cellular carbohydrate
metabolic process
biol
ogic
al_p SMEK1,PHKG2,ARNT,IGF2
roce
ss
1.34
726
324
9
positive regulation of ossification
biol
ogic
al_p NIPBL,MEF2A,CD276,ZBTB16
roce
ss
1.34
726
324
9
negative regulation of T cell proliferation
biol
ogic
al_p PTPN6,RC3H1,CD276,TNFRSF14
roce
ss
1.34
726
324
9
0
1
3.
4
5
E
0
1
3.
4
5
E
0
1
3.
4
5
E
0
1
3.
4
5
E
0
1
G
O:
00
48
70
1
G
O:
00
02
75
3
G
O:
00
90
54
5
G
O:
00
16
58
1
G
O:
00
45
embryonic cranial skeleton morphogenesis
biol
ogic
al_p NIPBL,RUNX2,MEF2A,SETD2
roce
ss
1.34
726
324
9
cytoplasmic pattern recognition receptor
signaling pathway
biol
ogic
al_p NOD1,TAB2,DDX58,IKBKB
roce
ss
1.34
726
324
9
CHD-type complex
cell
ular
_co CSNK2A1,APPL2
mpo
nent
1.64
627
385
6
NuRD complex
cell
ular
_co CSNK2A1,APPL2
mpo
nent
1.64
627
385
6
pronucleus
cell
ular
EED,TBP
_co
mpo
1.64
627
385
6
3.
4
5
E
0
1
3.
4
5
E
0
1
3.
4
6
E
0
1
3.
4
6
E
0
1
3.
4
6
E
12
0
G
O:
00
32
94
0
G
O:
00
32
27
1
G
O:
00
06
64
3
G
O:
00
16
82
9
nent
secretion by cell
biol
ogic
al_p
roce
ss
CADM1,BTN3A1,NLRP1,SEPT5,BDNF,SYTL4,GLS,PAX8,XBP1,NISCH,
PAM,ADAM8,CD9,PRKACA,DNM1L,VAMP7,SLC38A2,DISP1,SNCAIP,S
NAP23,CREB1,LCP2,RHBDF1,NF1,RAB31,CAPN10,LTBP4,PAFAH1B1,
SYTL2,AACS,NR1H3,STX2,IQGAP1,PHPT1,OXCT1,NECAB3,RAB8A,P
AK1,VPS45,CSF1R,C1QTNF3,FLNA,RAB5A,SCFD1,VTI1B,SLC25A6,R
AP1B,CANX,RUNX1,RHBDF2,CRCP,TLN1,LMF1,SPCS3,PDPK1,CD63
1.05
815
907
4
regulation of protein polymerization
biol
ogic ARPC4al_p TTLL3,CAPZB,ACTR3,ARPC2,WASH4P,VILL,TBCD,NCK2,ACTR2,TWF
roce 1
ss
1.17
153
326
membrane lipid metabolic process
biol
ogic
VAPB,GPAA1,SMPD4,PIGS,PIGG,CLN8,PIGN,HEXA,ST6GALNAC5,EL
al_p
OVL1,B4GALT4,PIGO,PPAP2A,ALG9
roce
ss
1.13
624
611
4
lyase activity
mol
ecul
ar_f
unct
ion
1.11
094
586
2
PTS,RAF1,SHMT2,PAM,RPP14,ECHDC1,ADCY4,NF1,NPR1,ADSL,GM
DS,PHPT1,FECH,OAZ1,HSD17B4,CA5B,THNSL2,ENO4,NTRK1
0
1
3.
4
7
E
0
1
3.
4
9
E
0
1
3.
4
9
E
0
1
3.
5
0
E
0
1
G
O:
00
30
66
2
G
O:
00
48
87
2
G
O:
00
97
20
2
G
O:
00
61
02
5
G
O:
00
48
coated vesicle membrane
cell
ular
HLA-DPB1,HLA-C,HLA-DQA1,SEC31A,MCFD2,EPN2,CLTCL1,HLA_co
F,CLTB,TMED3,TMED2,SEC31B
mpo
nent
1.15
013
652
9
homeostasis of number of cells
biol
ogic
BCL6,BCL2L11,SLC11A2,GIGYF2,RB1,IKBKB,NCOR1,MEF2A,FECH,C
al_p
DK6,ARNT,SMARCA4,ACIN1,TGFBR3,GATA2
roce
ss
1.12
899
155
activation of cysteine-type endopeptidase
activity
biol
ogic
NLRP1,BCL2L13,BCL2L11,NOD1,SLC11A2,MTCH1,DIABLO,TNFRSF1
al_p
0B
roce
ss
1.19
756
733
3
membrane fusion
biol
ogic
al_p RAB34,CD9,VAMP7,SNAP23,GNAI1,PLD6,RAB8A,VTI1B
roce
ss
1.19
756
733
3
mesoderm morphogenesis
biol
ogic
LEF1,PRKACA,FGFR1,SETD2,FOXC1,EYA2
al_p
roce
1.24
362
761
5
3.
5
1
E
0
1
3.
5
1
E
0
1
3.
5
2
E
0
1
3.
5
2
E
0
1
3.
5
2
E
33
2
G
O:
00
51
05
3
G
O:
00
44
29
1
G
O:
00
18
10
8
G
O:
00
03
70
7
ss
negative regulation of DNA metabolic
process
biol
ogic
al_p BCL6,FBXW7,STAG2,ACD,ERCC1,UBR5
roce
ss
1.24
362
761
5
cell-cell contact zone
cell
ular
_co CAMK2D,TLN2,FLCN,PAK1
mpo
nent
1.33
269
788
3
peptidyl-tyrosine phosphorylation
biol
ogic
CNTF,PTPN6,TNK2,FGFR1,NRP1,FYN,FBXW7,PXN,PTPRC,SEMA4D,
al_p
CSF1R,CLK3,ITGA5,PDGFRB,TNFRSF14,CLK4,IGF2
roce
ss
1.11
724
269
5
steroid hormone receptor activity
mol
ecul
ar_f
unct
ion
1.27
422
291
LEF1,RXRB,NR1H3,NR2C2,PGRMC2
0
1
3.
5
2
E
0
1
3.
5
3
E
0
1
3.
5
3
E
0
1
3.
5
6
E
0
1
G
O:
00
04
72
2
G
O:
00
17
04
8
G
O:
00
71
15
6
G
O:
00
06
66
4
G
O:
00
10
protein serine/threonine phosphatase
activity
mol
ecul
ar_f
unct
ion
PPP5C,PPM1F,PTEN,TIMM50,CDC14B
1.27
422
291
Rho GTPase binding
mol
ecul
ar_f
unct
ion
RTKN,DAAM1,IQGAP1,SRGAP2,FLNA
1.27
422
291
regulation of cell cycle arrest
biol
ogic PSMB10,PSMB9,CSNK2A1,PRKACA,ANAPC4,PLK1,WAC,MDM2,PKD2
al_p ,CASP2,RB1,PLK2,CHFR,CDK5RAP2,PSMC6,PSMC4,DGKZ,CDC14B,
roce HINFP,DBF4,PSMA1,RRP8
ss
1.09
777
005
5
glycolipid metabolic process
biol
ogic
al_p GPAA1,SMPD4,PIGS,PIGG,PIGN,HEXA,ST6GALNAC5,PIGO,ALG9
roce
ss
1.17
722
031
5
regulation of receptor activity
biol
ogic
HDAC6,MINK1,PKD2,BICD1,FBXW7,NCK2,LRPAP1,NLGN2,IGF2
al_p
roce
1.17
722
031
5
3.
5
6
E
0
1
3.
5
6
E
0
1
3.
5
6
E
0
1
3.
5
6
E
0
1
3.
5
6
E
46
9
G
O:
00
16
61
6
G
O:
00
18
10
7
G
O:
19
01
87
9
G
O:
00
50
80
6
ss
oxidoreductase activity, acting on the CHOH group of donors, NAD or NADP as
acceptor
mol
ecul
ar_f
unct
ion
peptidyl-threonine phosphorylation
biol
ogic
al_p SMAD7,PLK1,MAPK8,SPRED1,PDPK1
roce
ss
1.27
100
306
5
regulation of protein depolymerization
biol
ogic
al_p HDAC6,CAPZB,VILL,TWF1,CLASP1
roce
ss
1.27
100
306
5
positive regulation of synaptic transmission
biol
ogic
al_p NPTN,PLK2,PTEN,NLGN2,NTRK1
roce
ss
1.27
100
306
5
H6PD,HSD17B12,IDH3G,PTGR2,IDH1,IMPDH1,HSD17B4,IDH3B,PTGR
1,D2HGDH
1.16
437
610
8
0
1
3.
5
6
E
0
1
3.
5
8
E
0
1
3.
5
8
E
0
1
3.
5
8
E
0
1
G
O:
00
45
72
7
positive regulation of translation
biol
ogic
al_p UHMK1,UPF3A,PAIP1,CIRBP,PABPC1
roce
ss
1.27
100
306
5
alcohol catabolic process
biol
ogic
al_p GK5,SMPD4,PTEN,SNX17,ALDH3B1
roce
ss
1.27
100
306
5
lipid storage
biol
ogic
al_p ZC3H12A,NR1H3,HEXA,FBXW7,C3
roce
ss
1.27
100
306
5
G
O:
00
51
49
4
negative regulation of cytoskeleton
organization
biol
ogic
al_p HDAC6,CAPZB,VILL,CDK5RAP2,TBCD,TWF1,CLASP1
roce
ss
1.20
908
240
3
G
O:
00
02
regulation of myeloid leukocyte
differentiation
biol
ogic
LEF1,NF1,MITF,RB1,RUNX1,ACIN1,GATA2
al_p
roce
1.20
908
240
3
G
O:
00
46
16
4
G
O:
00
19
91
5
3.
5
8
E
0
1
3.
5
8
E
0
1
3.
5
8
E
0
1
3.
5
8
E
0
1
3.
5
8
E
76
1
G
O:
00
07
42
3
G
O:
00
02
22
4
G
O:
00
01
94
0
G
O:
00
32
58
5
ss
sensory organ development
biol
ogic
al_p
roce
ss
FZD6,BDNF,COL2A1,TBX2,CNTF,CUX1,LEF1,PAX8,BCL2L11,JAG2,CL
N8,TBX18,FGFR1,RAB18,HSF4,YY1,PFDN5,DFNA5,NF1,ZEB1,NIPBL,
CASP2,MITF,ALDH1A3,SMARCD3,CTNS,IMPDH1,GLI3,GAA,LPCAT1,P
DGFRB,COL8A1,SMARCA4,CLIC4,FOXC1,GATA2
1.07
067
278
1
toll-like receptor signaling pathway
biol
ogic
NOD1,TAB2,CREB1,RPS6KA5,NR1H3,IKBKB,MEF2A,MAPK8,DUSP6,P
al_p
DPK1
roce
ss
1.16
143
383
6
male pronucleus
cell
ular
_co TBP
mpo
nent
2.33
222
129
6
multivesicular body membrane
cell
ular
_co HGS
mpo
nent
2.33
222
129
6
0
1
3.
5
8
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
G
O:
00
05
85
1
eukaryotic translation initiation factor 2B
complex
cell
ular
_co EIF2B4
mpo
nent
2.33
222
129
6
signal recognition particle, endoplasmic
reticulum targeting
cell
ular
_co SRP9
mpo
nent
2.33
222
129
6
Elongator holoenzyme complex
cell
ular
_co ELP6
mpo
nent
2.33
222
129
6
G
O:
00
71
77
8
WINAC complex
cell
ular
_co SMARCA4
mpo
nent
2.33
222
129
6
G
O:
00
71
integral to cytosolic side of endoplasmic
reticulum membrane
cell
ular
PKD2
_co
mpo
2.33
222
129
6
G
O:
00
05
78
6
G
O:
00
33
58
8
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
45
8
G
O:
00
19
90
8
G
O:
00
42
58
7
G
O:
00
32
04
5
G
O:
00
70
93
7
nent
nuclear cyclin-dependent protein kinase
holoenzyme complex
cell
ular
_co CDK13
mpo
nent
2.33
222
129
6
glycogen granule
cell
ular
_co PCYT1A
mpo
nent
2.33
222
129
6
guanyl-nucleotide exchange factor complex
cell
ular
_co RAP1B
mpo
nent
2.33
222
129
6
CRD-mediated mRNA stability complex
cell
ular
_co DHX9
mpo
nent
2.33
222
129
6
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
G
O:
00
45
26
1
G
O:
00
43
19
0
G
O:
00
00
17
7
G
O:
00
05
86
9
G
O:
00
45
proton-transporting ATP synthase complex,
catalytic core F(1)
cell
ular
_co ATP5A1
mpo
nent
2.33
222
129
6
ATP-binding cassette (ABC) transporter
complex
cell
ular
_co ABCA2
mpo
nent
2.33
222
129
6
cytoplasmic exosome (RNase complex)
cell
ular
_co DIS3L
mpo
nent
2.33
222
129
6
dynactin complex
cell
ular
_co ACTR10
mpo
nent
2.33
222
129
6
apical cortex
cell
ular
TCHP
_co
mpo
2.33
222
129
6
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
17
9
G
O:
00
01
73
9
G
O:
00
42
78
8
G
O:
00
48
50
0
G
O:
00
30
90
4
nent
sex chromatin
cell
ular
_co EED
mpo
nent
2.33
222
129
6
polysomal ribosome
cell
ular
_co FMR1
mpo
nent
2.33
222
129
6
signal recognition particle
cell
ular
_co SRP9
mpo
nent
2.33
222
129
6
retromer complex
cell
ular
_co DENND4C
mpo
nent
2.33
222
129
6
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
G
O:
00
70
76
1
pre-snoRNP complex
cell
ular
_co PIH1D1
mpo
nent
2.33
222
129
6
condensin complex
cell
ular
_co NCAPD3
mpo
nent
2.33
222
129
6
SAGA complex
cell
ular
_co SUPT20H
mpo
nent
2.33
222
129
6
G
O:
00
00
80
5
X chromosome
cell
ular
_co SIN3B
mpo
nent
2.33
222
129
6
G
O:
00
04
transmembrane receptor protein tyrosine
kinase activity
mol
ecul
ar_f
unct
1.18
740
772
3
G
O:
00
00
79
6
G
O:
00
00
12
4
IGF1R,FGFR1,NRP1,FBXW7,NCK2,CSF1R,PDGFRB,NTRK1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
5
9
E
0
1
3.
6
0
E
71
4
G
O:
00
18
39
4
G
O:
00
01
96
8
G
O:
00
08
09
3
G
O:
00
70
06
3
ion
peptidyl-lysine acetylation
biol
ogic
NOC2L,LEF1,DR1,PHF15,RPS6KA5,FLCN,ING4,MSL1,SMARCA4,KAN
al_p
SL3,GATA2
roce
ss
1.14
882
912
7
fibronectin binding
mol
ecul
ar_f
unct
ion
HSD17B12,PLEKHA2
1.58
903
092
3
cytoskeletal adaptor activity
mol
ecul
ar_f
unct
ion
BICD1,NCK2
1.58
903
092
3
RNA polymerase binding
mol
ecul
ar_f
unct
ion
WAC,PAF1
1.58
903
092
3
0
1
3.
6
2
E
0
1
3.
6
2
E
0
1
3.
6
2
E
0
1
3.
6
2
E
0
1
G
O:
00
05
08
6
G
O:
00
07
15
9
G
O:
00
01
70
9
G
O:
00
72
21
0
G
O:
00
72
ARF guanyl-nucleotide exchange factor
activity
mol
ecul
ar_f
unct
ion
leukocyte cell-cell adhesion
biol
ogic
al_p PTPRC,SEMA4D,EZR,ITGA5
roce
ss
1.31
440
317
cell fate determination
biol
ogic
al_p TBX2,MEF2A,SMARCA4,GATA2
roce
ss
1.31
440
317
metanephric nephron development
biol
ogic
al_p PAX8,PKD2,PDGFRB,PKD1
roce
ss
1.31
440
317
nephron tubule development
biol
ogic
PAX8,PKD2,MEF2A,PKD1
al_p
roce
1.31
440
317
CYTH2,PSD3
1.58
903
092
3
3.
6
2
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
08
0
G
O:
00
55
00
6
G
O:
00
61
32
6
G
O:
00
48
70
4
G
O:
00
55
08
8
ss
cardiac cell development
biol
ogic
al_p LMNA,MEF2A,PDGFRB,GSK3A
roce
ss
1.31
440
317
renal tubule development
biol
ogic
al_p PAX8,PKD2,MEF2A,PKD1
roce
ss
1.31
440
317
embryonic skeletal system morphogenesis
biol
ogic
al_p COL2A1,ZEB1,NIPBL,RUNX2,MEF2A,GLI3,MDFI,SETD2
roce
ss
1.18
440
725
2
lipid homeostasis
biol
ogic
al_p EPHX2,NPC1,NR1H3,FBXW7,NCOR1,ABCA2,C1QTNF3,USF1
roce
ss
1.18
440
725
2
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
G
O:
00
72
00
6
nephron development
biol
ogic
al_p PAX8,PKD2,IQGAP1,MEF2A,SMAD4,PDGFRB,MYO1E,PKD1
roce
ss
1.18
440
725
2
forebrain morphogenesis
biol
ogic
al_p NF1,PTEN
roce
ss
1.58
501
558
7
positive regulation of cation channel activity
biol
ogic
al_p PKD2,IKBKB
roce
ss
1.58
501
558
7
G
O:
00
42
35
9
vitamin D metabolic process
biol
ogic
al_p CYP2R1,LGMN
roce
ss
1.58
501
558
7
G
O:
00
07
negative regulation of microtubule
depolymerization
biol
ogic
HDAC6,CLASP1
al_p
roce
1.58
501
558
7
G
O:
00
48
85
3
G
O:
20
01
25
9
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
02
6
G
O:
20
00
10
8
G
O:
00
42
09
5
G
O:
00
60
60
0
G
O:
00
00
95
9
ss
positive regulation of leukocyte apoptotic
process
biol
ogic
al_p ADAM8,MEF2A
roce
ss
1.58
501
558
7
interferon-gamma biosynthetic process
biol
ogic
al_p IL18,CD276
roce
ss
1.58
501
558
7
dichotomous subdivision of an epithelial
terminal unit
biol
ogic
al_p NRP1,CTSH
roce
ss
1.58
501
558
7
mitochondrial RNA metabolic process
biol
ogic
al_p TFAM,MTO1
roce
ss
1.58
501
558
7
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
G
O:
00
70
87
5
positive regulation of glycogen metabolic
process
biol
ogic
al_p PHKG2,IGF2
roce
ss
1.58
501
558
7
nicotinamide nucleotide biosynthetic
process
biol
ogic
al_p NADSYN1,NADK
roce
ss
1.58
501
558
7
activation of protein kinase A activity
biol
ogic
al_p PRKACA,ADCY4
roce
ss
1.58
501
558
7
G
O:
00
02
05
2
positive regulation of neuroblast
proliferation
biol
ogic
al_p SMARCD3,GLI3
roce
ss
1.58
501
558
7
G
O:
20
00
regulation of alpha-amino-3-hydroxy-5methyl-4-isoxazole propionate selective
glutamate receptor activity
biol
ogic
MINK1,NLGN2
al_p
roce
1.58
501
558
7
G
O:
00
19
35
9
G
O:
00
34
19
9
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
31
1
G
O:
00
35
30
4
G
O:
00
32
81
6
G
O:
00
06
54
4
G
O:
00
19
36
3
ss
regulation of protein dephosphorylation
biol
ogic
al_p IGBP1,SYMPK
roce
ss
1.58
501
558
7
positive regulation of natural killer cell
activation
biol
ogic
al_p IL15RA,IL18
roce
ss
1.58
501
558
7
glycine metabolic process
biol
ogic
al_p SHMT2,AMT
roce
ss
1.58
501
558
7
pyridine nucleotide biosynthetic process
biol
ogic
al_p NADSYN1,NADK
roce
ss
1.58
501
558
7
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
G
O:
00
46
17
4
G
O:
00
46
88
5
G
O:
00
90
27
9
G
O:
00
03
35
1
G
O:
00
70
polyol catabolic process
biol
ogic
al_p GK5,PTEN
roce
ss
1.58
501
558
7
regulation of hormone biosynthetic process
biol
ogic
al_p IGF1R,ARNT
roce
ss
1.58
501
558
7
regulation of calcium ion import
biol
ogic
al_p PKD2,PDGFRB
roce
ss
1.58
501
558
7
epithelial cilium movement
biol
ogic
al_p NPHP3,STK36
roce
ss
1.58
501
558
7
histone lysine demethylation
biol
ogic
JHDM1D,HSF4
al_p
roce
1.58
501
558
7
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
07
6
G
O:
00
45
73
7
G
O:
00
07
26
3
G
O:
20
00
27
8
G
O:
00
08
10
5
ss
positive regulation of cyclin-dependent
protein kinase activity
biol
ogic
al_p PKD2,PKD1
roce
ss
1.58
501
558
7
nitric oxide mediated signal transduction
biol
ogic
al_p DDAH1,DDAH2
roce
ss
1.58
501
558
7
regulation of DNA biosynthetic process
biol
ogic
al_p NOX4,PDGFRB
roce
ss
1.58
501
558
7
asymmetric protein localization
biol
ogic
al_p GOPC,RAB10
roce
ss
1.58
501
558
7
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
3.
6
3
E
0
1
G
O:
00
70
22
9
negative regulation of lymphocyte apoptotic
process
biol
ogic
al_p NOC2L,BCL6
roce
ss
1.58
501
558
7
clathrin-coated vesicle
cell
ular CADM1,SEPT5,BDNF,HLA-DPB1,SYTL4,HLA_co DQA1,RAB35,TNK2,SYTL2,EPN2,CLTCL1,CLTB,AAK1,GOPC,MYO1E,
mpo CTTNBP2
nent
1.11
389
673
8
phosphatidylinositol-4,5-bisphosphate
binding
mol
ecul
ar_f
unct
ion
RAB35,SYTL2,TWF1
1.39
725
132
9
G
O:
00
08
17
3
RNA methyltransferase activity
mol
ecul
ar_f
unct
ion
METTL3,WDR4,TGS1
1.39
725
132
9
G
O:
00
08
monocarboxylic acid transmembrane
transporter activity
mol
ecul
ar_f
unct
SLC16A3,SLC26A6,SLC16A1
1.39
725
132
9
G
O:
00
30
13
6
G
O:
00
05
54
6
3.
6
3
E
0
1
3.
6
4
E
0
1
3.
6
5
E
0
1
3.
6
5
E
0
1
3.
6
5
E
02
8
G
O:
00
46
87
5
G
O:
00
45
20
2
G
O:
00
01
67
8
G
O:
00
06
02
6
ion
ephrin receptor binding
mol
ecul
ar_f
unct
ion
SIPA1L1,FYN,NTRK1
1.39
725
132
9
synapse
cell
ular
_co
mpo
nent
CADM1,UTRN,SEPT5,BDNF,FMR1,SYTL4,SIPA1L1,MINK1,PDLIM5,AC
TR3,PRKACA,VAMP7,CAMK2D,PLCB4,SNCAIP,SHARPIN,MDM2,SNA
P23,TLN2,NPTN,ITGA3,SYTL2,SYNE1,FYN,CEP112,SRGAP2,CLSTN2,
RAB8A,AAK1,GOPC,ERC1,ITGA5,NLGN2,GPHN,TANC1,PSD3,CTTNB
P2,SEPT2
1.06
562
415
9
cellular glucose homeostasis
biol
ogic
al_p PRKACA,AACS,PHPT1,MEF2A,OXCT1,NOX4
roce
ss
1.22
478
477
2
aminoglycan catabolic process
biol
ogic
al_p HEXA,HGSNAT,GUSB,CTBS,ACAN,FMOD
roce
ss
1.22
478
477
2
0
1
3.
6
5
E
0
1
3.
6
5
E
0
1
3.
6
5
E
0
1
3.
6
5
E
0
1
G
O:
00
50
87
9
multicellular organismal movement
biol
ogic
al_p CLN8,GIGYF2,GAA
roce
ss
1.39
372
060
3
regulation of extrinsic apoptotic signaling
pathway
biol
ogic
al_p FYN,LTBR,UNC5B
roce
ss
1.39
372
060
3
musculoskeletal movement
biol
ogic
al_p CLN8,GIGYF2,GAA
roce
ss
1.39
372
060
3
G
O:
00
32
46
5
regulation of cytokinesis
biol
ogic
al_p IGF1R,PRPF40A,FLCN
roce
ss
1.39
372
060
3
G
O:
00
50
negative regulation of peptidyl-tyrosine
phosphorylation
biol
ogic
PTPN6,PTPRC,SEMA4D
al_p
roce
1.39
372
060
3
G
O:
20
01
23
6
G
O:
00
50
88
1
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
6
E
73
2
G
O:
00
42
49
1
G
O:
00
45
60
0
G
O:
00
09
13
2
G
O:
00
00
18
8
ss
auditory receptor cell differentiation
biol
ogic
al_p CUX1,JAG2,FGFR1
roce
ss
1.39
372
060
3
positive regulation of fat cell differentiation
biol
ogic
al_p ZC3H12A,CREB1,ZBTB16
roce
ss
1.39
372
060
3
nucleoside diphosphate metabolic process
biol
ogic
al_p CMPK2,DTYMK,AK5
roce
ss
1.39
372
060
3
inactivation of MAPK activity
biol
ogic
al_p RGS3,SPRED1,DUSP6
roce
ss
1.39
372
060
3
0
1
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
6
E
0
1
G
O:
00
42
09
2
type 2 immune response
biol
ogic
al_p BCL6,IL18,STAT6
roce
ss
1.39
372
060
3
collagen biosynthetic process
biol
ogic
al_p SERPINH1,IL18,PDGFRB
roce
ss
1.39
372
060
3
regulation of insulin receptor signaling
pathway
biol
ogic
al_p GRB10,GSK3A,IGF2
roce
ss
1.39
372
060
3
G
O:
00
51
40
2
neuron apoptotic process
biol
ogic
NLRP1,BDNF,CNTF,BCL2L11,ADAM8,NF1,CASP2,RB1,IL18,LGMN,ME
al_p
F2A,GAPDH,NRBP2,NTRK1
roce
ss
1.12
271
937
4
G
O:
00
31
positive regulation of protein complex
assembly
biol
ogic HDAC6,ARPC4al_p TTLL3,BCL2L11,ACTR3,BCLAF1,ARPC2,WASH4P,NCK2,ACTR2
roce
1.16
590
088
9
G
O:
00
32
96
4
G
O:
00
46
62
6
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
6
E
0
1
3.
6
7
E
33
4
G
O:
00
60
04
1
G
O:
00
44
42
0
G
O:
00
18
21
2
G
O:
00
07
01
5
ss
retina development in camera-type eye
biol
ogic
CLN8,PFDN5,CASP2,SMARCD3,IMPDH1,LPCAT1,PDGFRB,SMARCA4
al_p
,CLIC4
roce
ss
1.16
590
088
9
extracellular matrix part
cell
ular
LAMB1,COL9A1,COL2A1,ADAMTS1,COL16A1,COL14A1,COL12A1,CO
_co
L18A1,COL9A3,C1QTNF3,COL8A1,RUNX1,COL13A1,PLOD2,ACAN
mpo
nent
1.11
648
891
8
peptidyl-tyrosine modification
biol
ogic
CNTF,PTPN6,TNK2,FGFR1,NRP1,FYN,FBXW7,PXN,PTPRC,SEMA4D,
al_p
CSF1R,CLK3,ITGA5,PDGFRB,TNFRSF14,CLK4,IGF2
roce
ss
1.10
644
807
9
actin filament organization
biol
ogic ARPC4al_p TTLL3,CAPZB,RHOF,ACTR3,VASP,PPM1F,SSH2,ARPC2,WASH4P,VIL
roce L,PAK1,NCK2,ACTR2,EZR,FHOD1,FLNA,NOX4,TWF1,SSH1
ss
1.09
862
668
4
0
1
3.
6
7
E
0
1
3.
6
7
E
0
1
3.
6
8
E
0
1
3.
6
9
E
0
1
G
O:
00
30
11
8
G
O:
00
01
72
5
G
O:
00
35
49
7
G
O:
00
03
99
7
G
O:
00
15
clathrin coat
cell
ular
_co AP4B1,EPN2,CLTCL1,CLTB
mpo
nent
1.30
170
490
9
stress fiber
cell
ular
_co TPM4,DAAM1,MYLK,FHOD1
mpo
nent
1.30
170
490
9
cAMP response element binding
mol
ecul
ar_f
unct
ion
CREB1
2.25
112
714
2
acyl-CoA oxidase activity
mol
ecul
ar_f
unct
ion
ACAA1
2.25
112
714
2
glycine transmembrane transporter activity
mol
ecul
ar_f
unct
SLC38A5
2.25
112
714
2
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
18
7
G
O:
00
46
97
4
G
O:
00
04
55
8
G
O:
00
05
38
4
G
O:
00
30
27
4
ion
histone methyltransferase activity (H3-K9
specific)
mol
ecul
ar_f
unct
ion
alpha-glucosidase activity
mol
ecul
ar_f
unct
ion
manganese ion transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
LIM domain binding
mol
ecul
ar_f
unct
ion
EHMT1
2.25
112
714
2
GAA
2.25
112
714
2
SLC11A2
2.25
112
714
2
TLN1
2.25
112
714
2
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
42
97
9
G
O:
00
30
95
7
G
O:
00
03
98
8
G
O:
00
04
49
9
G
O:
00
70
ornithine decarboxylase regulator activity
mol
ecul
ar_f
unct
ion
Tat protein binding
mol
ecul
ar_f
unct
ion
acetyl-CoA C-acyltransferase activity
mol
ecul
ar_f
unct
ion
N,N-dimethylaniline monooxygenase
activity
mol
ecul
ar_f
unct
ion
uridylyltransferase activity
mol
ecul
ar_f
unct
OAZ1
2.25
112
714
2
SMARCA4
2.25
112
714
2
ACAA1
2.25
112
714
2
FMO2
2.25
112
714
2
GALT
2.25
112
714
2
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
56
9
G
O:
00
08
07
9
G
O:
00
16
67
0
G
O:
00
05
16
7
G
O:
00
10
31
4
ion
translation termination factor activity
mol
ecul
ar_f
unct
ion
oxidoreductase activity, acting on a sulfur
group of donors, oxygen as acceptor
mol
ecul
ar_f
unct
ion
neurotrophin TRK receptor binding
mol
ecul
ar_f
unct
ion
phosphatidylinositol-5-phosphate binding
mol
ecul
ar_f
unct
ion
MTRF1L
2.25
112
714
2
QSOX1
2.25
112
714
2
BDNF
2.25
112
714
2
LANCL2
2.25
112
714
2
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
00
09
9
G
O:
00
34
59
4
G
O:
00
08
76
2
G
O:
00
03
74
7
G
O:
00
04
sulfur amino acid transmembrane
transporter activity
mol
ecul
ar_f
unct
ion
phosphatidylinositol trisphosphate
phosphatase activity
mol
ecul
ar_f
unct
ion
UDP-N-acetylmuramate dehydrogenase
activity
mol
ecul
ar_f
unct
ion
translation release factor activity
mol
ecul
ar_f
unct
ion
aminomethyltransferase activity
mol
ecul
ar_f
unct
CTNS
2.25
112
714
2
PTEN
2.25
112
714
2
D2HGDH
2.25
112
714
2
MTRF1L
2.25
112
714
2
AMT
2.25
112
714
2
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
04
7
G
O:
00
16
41
7
G
O:
00
03
95
8
G
O:
00
34
21
2
G
O:
00
00
01
4
ion
S-acyltransferase activity
mol
ecul
ar_f
unct
ion
NADPH-hemoprotein reductase activity
mol
ecul
ar_f
unct
ion
peptide N-acetyltransferase activity
mol
ecul
ar_f
unct
ion
single-stranded DNA specific
endodeoxyribonuclease activity
mol
ecul
ar_f
unct
ion
DLST
2.25
112
714
2
MTRR
2.25
112
714
2
NAA10
2.25
112
714
2
ERCC1
2.25
112
714
2
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
04
72
3
G
O:
00
05
13
8
G
O:
00
15
10
6
G
O:
00
48
40
6
G
O:
00
17
calcium-dependent protein serine/threonine
phosphatase activity
mol
ecul
ar_f
unct
ion
interleukin-6 receptor binding
mol
ecul
ar_f
unct
ion
bicarbonate transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
nerve growth factor binding
mol
ecul
ar_f
unct
ion
chloride channel regulator activity
mol
ecul
ar_f
unct
PPM1F
2.25
112
714
2
CNTF
2.25
112
714
2
SLC4A4
2.25
112
714
2
NTRK1
2.25
112
714
2
SGK1
2.25
112
714
2
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
08
1
G
O:
00
08
43
2
G
O:
00
08
33
1
G
O:
00
72
34
9
G
O:
00
16
40
6
ion
JUN kinase binding
mol
ecul
ar_f
unct
ion
high voltage-gated calcium channel activity
mol
ecul
ar_f
unct
ion
modified amino acid transmembrane
transporter activity
mol
ecul
ar_f
unct
ion
carnitine O-acyltransferase activity
mol
ecul
ar_f
unct
ion
MAPK8IP3
2.25
112
714
2
CACNB1
2.25
112
714
2
CTNS
2.25
112
714
2
CPT1B
2.25
112
714
2
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
15
20
5
G
O:
00
43
48
2
G
O:
00
51
29
9
G
O:
00
55
09
8
G
O:
00
71
nucleobase transmembrane transporter
activity
mol
ecul
ar_f
unct
ion
SLC23A2
2.25
112
714
2
cellular pigment accumulation
biol
ogic
al_p BLOC1S5
roce
ss
2.24
543
874
9
centrosome separation
biol
ogic
al_p RANBP1
roce
ss
2.24
543
874
9
response to low-density lipoprotein particle
stimulus
biol
ogic
al_p NPC1
roce
ss
2.24
543
874
9
cellular response to ATP
biol
ogic
SSH1
al_p
roce
2.24
543
874
9
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
31
8
G
O:
00
60
37
3
G
O:
00
06
47
7
G
O:
00
90
04
5
G
O:
00
43
47
6
ss
regulation of ventricular cardiac muscle cell
membrane depolarization
biol
ogic
al_p SMAD7
roce
ss
2.24
543
874
9
protein sulfation
biol
ogic
al_p UST
roce
ss
2.24
543
874
9
positive regulation of deacetylase activity
biol
ogic
al_p MAPK8
roce
ss
2.24
543
874
9
pigment accumulation
biol
ogic
al_p BLOC1S5
roce
ss
2.24
543
874
9
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
22
41
7
G
O:
00
80
18
2
G
O:
20
00
18
8
G
O:
00
30
17
4
G
O:
00
06
protein maturation by protein folding
biol
ogic
al_p FKBP1A
roce
ss
2.24
543
874
9
histone H3-K4 trimethylation
biol
ogic
al_p WDR61
roce
ss
2.24
543
874
9
regulation of cholesterol homeostasis
biol
ogic
al_p NR1H3
roce
ss
2.24
543
874
9
regulation of DNA-dependent DNA
replication initiation
biol
ogic
al_p CIZ1
roce
ss
2.24
543
874
9
ornithine metabolic process
biol
ogic
ALDH18A1
al_p
roce
2.24
543
874
9
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
59
1
G
O:
00
33
29
9
ss
secretion of lysosomal enzymes
biol
ogic
al_p NR1H3
roce
ss
2.24
543
874
9
G
O:
00
08
09
0
retrograde axon cargo transport
biol
ogic
al_p PAFAH1B1
roce
ss
2.24
543
874
9
G
O:
19
00
15
3
positive regulation of nuclear-transcribed
mRNA catabolic process, deadenylationdependent decay
biol
ogic
al_p PABPC1
roce
ss
2.24
543
874
9
negative regulation of calcium ion transport
into cytosol
biol
ogic
al_p FKBP1A
roce
ss
2.24
543
874
9
G
O:
00
10
52
3
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
60
62
8
G
O:
00
50
84
7
G
O:
20
01
05
4
G
O:
00
46
14
6
G
O:
00
60
regulation of ER to Golgi vesicle-mediated
transport
biol
ogic
al_p SCFD1
roce
ss
2.24
543
874
9
progesterone receptor signaling pathway
biol
ogic
al_p UBR5
roce
ss
2.24
543
874
9
negative regulation of mesenchymal cell
apoptotic process
biol
ogic
al_p PAX8
roce
ss
2.24
543
874
9
tetrahydrobiopterin metabolic process
biol
ogic
al_p PTS
roce
ss
2.24
543
874
9
relaxation of vascular smooth muscle
biol
ogic
RGS2
al_p
roce
2.24
543
874
9
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
08
7
G
O:
00
70
24
5
G
O:
00
30
85
3
G
O:
00
21
86
9
G
O:
20
00
02
0
ss
positive regulation of thymocyte apoptotic
process
biol
ogic
al_p ADAM8
roce
ss
2.24
543
874
9
negative regulation of granulocyte
differentiation
biol
ogic
al_p RUNX1
roce
ss
2.24
543
874
9
forebrain ventricular zone progenitor cell
division
biol
ogic
al_p FGFR1
roce
ss
2.24
543
874
9
positive regulation of male gonad
development
biol
ogic
al_p ZFPM2
roce
ss
2.24
543
874
9
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
42
98
3
amyloid precursor protein biosynthetic
process
biol
ogic
al_p NECAB3
roce
ss
2.24
543
874
9
tonic smooth muscle contraction
biol
ogic
al_p MYLK
roce
ss
2.24
543
874
9
cellular response to macrophage colonystimulating factor stimulus
biol
ogic
al_p CSF1R
roce
ss
2.24
543
874
9
G
O:
00
70
19
8
protein localization to chromosome,
telomeric region
biol
ogic
al_p ACD
roce
ss
2.24
543
874
9
G
O:
00
34
very-low-density lipoprotein particle
clearance
biol
ogic
LRPAP1
al_p
roce
2.24
543
874
9
G
O:
00
14
82
0
G
O:
00
36
00
6
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
44
7
G
O:
00
45
83
7
G
O:
00
90
34
3
G
O:
00
19
40
5
G
O:
00
14
02
9
ss
negative regulation of membrane potential
biol
ogic
al_p PTEN
roce
ss
2.24
543
874
9
positive regulation of cell aging
biol
ogic
al_p LMNA
roce
ss
2.24
543
874
9
alditol catabolic process
biol
ogic
al_p GK5
roce
ss
2.24
543
874
9
neural crest formation
biol
ogic
al_p FOXC1
roce
ss
2.24
543
874
9
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
35
72
8
G
O:
00
32
51
6
G
O:
00
46
83
1
G
O:
00
19
38
8
G
O:
00
60
response to hepatocyte growth factor
stimulus
biol
ogic
al_p NRP1
roce
ss
2.24
543
874
9
positive regulation of phosphoprotein
phosphatase activity
biol
ogic
al_p PDGFRB
roce
ss
2.24
543
874
9
regulation of RNA export from nucleus
biol
ogic
al_p NCBP2
roce
ss
2.24
543
874
9
galactose catabolic process
biol
ogic
al_p GALT
roce
ss
2.24
543
874
9
establishment of blood-brain barrier
biol
ogic
ENG
al_p
roce
2.24
543
874
9
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
85
6
G
O:
00
43
61
9
G
O:
00
35
50
2
G
O:
00
31
64
3
G
O:
00
42
98
4
ss
regulation of transcription from RNA
polymerase II promoter in response to
oxidative stress
biol
ogic
al_p ARNT
roce
ss
2.24
543
874
9
metanephric part of ureteric bud
development
biol
ogic
al_p PKD2
roce
ss
2.24
543
874
9
positive regulation of myelination
biol
ogic
al_p TENM4
roce
ss
2.24
543
874
9
regulation of amyloid precursor protein
biosynthetic process
biol
ogic
al_p NECAB3
roce
ss
2.24
543
874
9
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
45
72
2
positive regulation of gluconeogenesis
biol
ogic
al_p SMEK1
roce
ss
2.24
543
874
9
histone-serine phosphorylation
biol
ogic
al_p RPS6KA5
roce
ss
2.24
543
874
9
manganese ion transmembrane transport
biol
ogic
al_p SLC11A2
roce
ss
2.24
543
874
9
G
O:
00
10
59
2
positive regulation of lamellipodium
assembly
biol
ogic
al_p ACTR3
roce
ss
2.24
543
874
9
G
O:
00
72
microtubule anchoring at microtubule
organizing center
biol
ogic
BICD1
al_p
roce
2.24
543
874
9
G
O:
00
35
40
4
G
O:
00
71
42
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
39
3
G
O:
00
10
88
7
G
O:
00
06
06
8
G
O:
00
21
55
9
G
O:
00
00
24
4
ss
negative regulation of cholesterol storage
biol
ogic
al_p NR1H3
roce
ss
2.24
543
874
9
ethanol catabolic process
biol
ogic
al_p ALDH3B1
roce
ss
2.24
543
874
9
trigeminal nerve development
biol
ogic
al_p NRP1
roce
ss
2.24
543
874
9
assembly of spliceosomal tri-snRNP
biol
ogic
al_p SRSF10
roce
ss
2.24
543
874
9
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
G
O:
00
30
57
9
ubiquitin-dependent SMAD protein catabolic
process
biol
ogic
al_p TGFB1I1
roce
ss
2.24
543
874
9
positive regulation of hypersensitivity
biol
ogic
al_p C3
roce
ss
2.24
543
874
9
response to macrophage colony-stimulating
factor stimulus
biol
ogic
al_p CSF1R
roce
ss
2.24
543
874
9
G
O:
00
06
18
9
de novo IMP biosynthetic process
biol
ogic
al_p ADSL
roce
ss
2.24
543
874
9
G
O:
00
35
cellular response to hepatocyte growth
factor stimulus
biol
ogic
NRP1
al_p
roce
2.24
543
874
9
G
O:
00
02
88
5
G
O:
00
36
00
5
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
0
1
3.
7
0
E
72
9
G
O:
00
06
53
7
ss
glutamate biosynthetic process
biol
ogic
al_p GLS
roce
ss
2.24
543
874
9
regulation of mesenchymal cell apoptotic
process
biol
ogic
al_p PAX8
roce
ss
2.24
543
874
9
G
O:
00
71
90
7
determination of digestive tract left/right
asym