The β-tail domain (βTD) regulates physiologic ligand
binding to integrin CD11b/CD18
by Vineet Gupta, Annette Gylling, José Luis Alonso, Takashi Sugimori, Petre
Ianakiev, Jiang-Ping Xiong, and M. Amin Arnaout
Blood
Volume 109(8):3513-3520
April 15, 2007
©2007 by American Society of Hematology
Spatial relationships of the βTD domain.
Vineet Gupta et al. Blood 2007;109:3513-3520
©2007 by American Society of Hematology
Surface expression and iC3b binding of WT and mutant CD11b/CD18 in HEK293 cells.
Vineet Gupta et al. Blood 2007;109:3513-3520
©2007 by American Society of Hematology
Physiologic ligand binding of K562 stably expressing WT and βTD mutant CD11b/CD18.
Vineet Gupta et al. Blood 2007;109:3513-3520
©2007 by American Society of Hematology
Binding and spreading by WT and βTD mutant CD11b/CD18 to iC3b-coated plates.
Vineet Gupta et al. Blood 2007;109:3513-3520
©2007 by American Society of Hematology
Reactivity of WT and βTD mutant CD11b/CD18 with conformation-sensitive mAb 24.
Vineet Gupta et al. Blood 2007;109:3513-3520
©2007 by American Society of Hematology
Reactivity of WT and βTD mutant CD11b/CD18 with genu extension–dependent mAb KIM127.
Vineet Gupta et al. Blood 2007;109:3513-3520
©2007 by American Society of Hematology
A mechanistic model for the conformational changes during integrin activation and signaling.
Vineet Gupta et al. Blood 2007;109:3513-3520
©2007 by American Society of Hematology