Stevia 1989
409.
Effects of the nonsteroidal anti-inflammatory drug mefenamic acid on
energy metabolism in the perfused rat liver
Biochemical Pharmacology, Volume 38, Issue 5, 1 March 1989, Pages 823-830
Fumie Suzuki Kemmelmeier, Adelar Bracht
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Abstract
The action of mefenamic acid, a nonsteroidal anti-inflammatory drug, on energy
metabolism in the isolated perfused rat liver was investigated. Mefenamic acid in the
range between 0.1 and 1.0 mM was infused to livers from well-fed rats and from 24-hr
fasted rats. The former were perfused with substrate-free Krebs/Henseleit-bicarbonate
buffer, allowing the measurement of glycogenolysis and glycolysis from endogenous
glycogen. The livers from 24-hr fasted rats, on the other hand, were perfused with
Krebs/Henseleit-bicarbonate buffer containing fructose, thus allowing the measurement
of fructolysis and glucose synthesis. Oxygen consumption was measured in both cases.
When present in the range between 0.1 and 0.5 mM, mefenamic acid increased
glycolysis, oxygen uptake, glycogenolysis and fructolysis. Higher concentrations,
depending on the perfusion conditions, were inhibitory. Glucose production from
exogenous fructose, on the other hand, was inhibited at low mefenamic acid
concentrations. In general terms, the effects of mefenamic acid on energy metabolism
seemed to be the primary consequence of its uncoupling action on the respiratory chain.
This conclusion is supported mainly by the opposite effects on glucose synthesis
(inhibition) and oxygen consumption (activation). The intracellular concentration of
mefenamic acid is much higher than the extracellular one, a phenomenon which may
represent binding to intracellular membrane or proteins.
410. Sucrose: Nutritional and safety aspects : Edited by Gaston Vettorazzi and Ian
Macdonald. ILSI Human Nutritional Reviews, Springer-Verlag, London, 1988,
£22.00. ISBN 3-540-19526-2. Pp. 192
Appetite, Volume 12, Issue 1, February 1989, Page 81
Gordon Birch
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Abstract
No abstract is available for this article.
411.
Developments in sweeteners—3 : Edited by T. H. Grenby. Elsevier
Applied Science, 1988, £43.00. ISBN 1-85166-104-2. Pp. 322
Appetite, Volume 12, Issue 1, February 1989, Page 81
Gordon Birch
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Abstract
No abstract is available for this article.
412. Food engineering data book: G. D. Hayes. Longman Scientific and
Technical, 1987. ISBN 0-582-49505-9. Price £24·95
Food Chemistry, Volume 32, Issue 4, 1989, Pages 319-320
M.J. Lewis
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Abstract
No abstract is available for this article.
413. Developments in sweeteners—3: Edited by T. H. Grenby. Elsevier Applied
Science, London, 1988. x + 322 pp. ISBN 1-85166-104-2. Price £43·00
Food Chemistry, Volume 32, Issue 4, 1989, Pages 320-321
Gordon Birch
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Abstract
No abstract is available for this article.
414. Contents of volume 20
General Pharmacology: The Vascular System, Volume 20, Issue 6, 1989, Pages iii-xiv
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Abstract
No abstract is available for this article.
415. Chronic administration of aqueous extract of Stevia rebaudiana (Bert.)
Bertoni in rats: Endocrine effects
General Pharmacology: The Vascular System, Volume 20, Issue 2, 1989, Pages 187-191
Ricardo M. Oliveira-Filho1, Olivia A. Uehara1, Conceição A.S.A. Minetti2 and Luiz
B.S. Valle1
of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508 São Paulo (SP, Brazil)
of Embryology and Histology, Institute of Biomedical Sciences, University of São Paulo, 05508 São
Paulo (SP, Brazil)
1Department
2Department
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Abstract | References
Oliveira-Filho , Ricardo M.; Olivia A. Uehara; Conceição A.S.A. Minetti and Luiz
B.S. Valle (1989). Chronic administration of aqueous extract of Stevia
rebaudiana (Bert.) Bertoni in rats: Endocrine effects. General Pharmacology:
The Vascular System 20(2): 187-191
‫ضارة‬
Abstract
1. 1. The effects of the active principles of S. rebaudiana (SR) on endocrine parameters
of male rats were studied upon chronic administrations (60 days) of a concentrated, crude
extract of its leaves, starting at prepubertal age (25–30 days old).
2. 2. The following determinations were made: glycemia; serum levels of T3 and T4;
available binding sites in thyroid hormone-binding proteins (T3R index); binding of
[3H]R1881 to prostate cytosol; zinc content in prostate, testis, submandibular salivary
gland (SMG) and pancreas; water content in testis and prostate. The body weight gain
and the final weight of testis, prostate, seminal vesicle, SMG and adrenal were also
studied.
3. 3. Results showed that the SR-treated group did not significantly differ from the
control group, with exception to the seminal vesicle weight, which fell by about 60%.
4. 4. It is concluded that if the SR extract does have some potential to decrease rat
fertility at all, this effect is almost certainly not exerted on the male.
416.
Sesquiterpene lactones and other terpenes from Geigeria species
Phytochemistry, Volume 28, Issue 11, 1989, Pages 3105-3120
C. Zdero, F. Bohlmann
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Abstract
The investigation of seven further Geigeria species afforded, in addition to known
compounds, 28 new sesquiterpene lactones, including two dimeric ones and a fulvene
lactone, an eremophilane ketone, six nerolidol derivatives, including two glucosides,
5,13-dihydroxygeranyllinalol, a glucoside of a myrcene derivative and two ivaxillarane
acids. The structures were elucidated by high field NMR techniques. The
chemotaxonomic aspects are discussed.
417. Isolation and preparation of two longipinene derivatives from Stevia
subpubescens
Phytochemistry, Volume 28, Issue 1, 1989, Pages 265-268
Luisa U. Román, Juan D. Hernández, Raúl Castañeda, Carlos M. Cerda, Pedro JosephNathan
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Abstract
The roots of Stevia subpubescens Lag. afforded longicyclene, longipin-2-ene-7β,9α-diol1-one diangelate and longipin-2-ene-7β,9α-diol-1-one 7-angelate-9-seneciate. A synthetic
pathway involving the protection of the C-7 hydroxyl group of longipin-2-ene-7β,9αdiol-1-one with p-nitrobenzoyl chloride allowed the preparation of the 7-angelate-9seneciate, while the diangelate was prepared by direct esterification.
418. Prochamazulene sesquiterpene lactones from Stevia serrata
Phytochemistry, Volume 28, Issue 12, 1989, Pages 3526-3527
José S. Calderón, Leovigildo Quijano, Federico Gómez, Tirso Ríos
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Abstract
The leaves of Stevia serrata afforded two new sesquiterpene lactones. Their structures
and stereochemistry were established by spectral methods, mainly 1H NMR.
419. ent-clerodanes and other constituents from bolivian Baccharis species
Phytochemistry, Volume 28, Issue 2, 1989, Pages 531-542
C. Zdero, F. Bohlmann, J. C. Solomon, R. M. King, H. Robinson
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Abstract
Investigation of seven Bolivian Baccharis species afforded in addition to known
compounds 17 ent-clerodane, 10 ent-labdane, two bisabolene, a germacrane, a cadinane,
a guaiane and a p-coumaric acid derivative. In one case the ent-labdane was linked with a
bisabolene derivative via a malonate group. The structures were elucidated mainly by
high field NMR techniques.
420. 10-Epideoxycumambrin b and other constituents of Stevia yaconensis var.
subeglandulosa
Phytochemistry, Volume 28, Issue 7, 1989, Pages 1925-1929
Virginia E. Sosa, Juan C. Oberti, Roberto R. Gil, Edmundo A. Rúveda, Virgil L.
Goedken, Alicia B, Gutiérrez, Werner Herz
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Abstract
The aerial parts of Stevia yaconensis var. subeglandulosa afforded in addition to the
known guaianolides ludartin and dehydroleucodin a new guaianolide 10-epi-8deoxycumambrin B whose relative and absolute configurations were established by X-ray
crystallography. Chemical transformations of ludartin established its relative and absolute
stereochemistry.
421. Guaianolides, heliangolides and other constituents from Stevia alpina
Phytochemistry, Volume 28, Issue 7, 1989, Pages 1931-1935
Carola S. de Heluani, Marina P. de Lampasona, César A. N. Catalán, Virgil L. Goedken,
Alicia B. Gutiérrez, Werner Herz
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Abstract
The aerial parts of Stevia alpina afforded in addition to estafietin, dehydroleucodin,
achillin, 2-oxo-8-deoxyligustrin and two known heliangolides two new guaianolides, the
two epimeric 10(14)-epoxyestafietins, and the new heliangolide 3-acetylpulverolide. The
stereochemistry of the new epoxyestafietins was confirmed by X-ray analysis of one of
the epimers.
422. Naturally occurring cadinenes
Phytochemistry, Volume 28, Issue 8, 1989, Pages 2007-2037
Manobjyoti Bordoloi, Vishunu S. Shukla, Subhan C. Nath, Ram P. Sharma
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Abstract
Naturally occurring cadinenes appearing in the literature up to the end of 1986 have been
reviewed.
423. Diterpenes from Fleischmannia hymenophylla and Brickellia laciniata
Phytochemistry, Volume 28, Issue 10, 1989, Pages 2741-2744
J. Jakupovic, F. Tsichritzis, G. Tamayo-Castillo, V. Castro, F. Bohlmann, E. Boldt
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Abstract
The aerial parts of Fleischmannia hymenolepis gave in addition to phytol and sesamin a
new derivative of beyerene named hymenophylloide. The aerial parts of Brickellia
laciniata afforded several new labdane derivatives and a heliangolide. Structures were
elucidated by spectroscopic methods and the absolute configuration of the labdanes were
determined by CD measurements.
424. Platycarphol and other kaurene derivatives from Platycarpha carlinoides
Phytochemistry, Volume 28, Issue 10, 1989, Pages 2745-2751
C. Zdero, F. Bohlmann
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Abstract
The extract of the aerial parts of Platycarpha carlinoides gave, in addition to some
known compounds, 10 ent-kaurenes including two glycosides, one being an
allopyranoside, and three norkaurene derivatives. The structures were elucidated by high
field 1H NMR techniques and a few chemical transformations. The doubtful position of
the genus Platycarpha is discussed again following the new chemical findings.
425.Guaianolides from Stevia sanguinea
Phytochemistry, Volume 28, Issue 10, 1989, Pages 2841-2843
Roberto R. Gil, Jorge A. Pastoriza, Juan C. Oberti, Alicia B. Gutiérrez, Werner Herz
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Abstract
The aerial parts of Stevia sanguinea afforded four new guaianolides and the flavone
hispidulin.
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