Neuropsychological outcomes in a two-year African-based pediatric observational study
Michael
1Michigan
1
Boivin ,
2
Chernoff ,
3
Zimmer ,
4
Laughton ,
5
Dangarembizi ,
Miriam
Bonnie
Barbara
Mutsa Bwakura
6
7
8
4
9
Portia Kamthunzi , Linda Barlow-Mosha , Avy Violari , Mark Cotton , Paul Palumbo ,
on behalf of the IMPAACT P1104s Study Team
2Harvard
3Frontier
4Stellenbosch
5University
826
6
Zimbabwe, UNC-Lilongwe
State University,
University,
Science,
University RSA,
of
Malawi,
7Makerere University-Johns Hopkins University Uganda, 8University of Witwatersrand RSA, 9Hitchcock Medical Center - Dartmouth
NEUROPSYCHOLOGY TESTS/RESULTS
INTRODUCTION
SUMMARY NEUROPSYCHOLOGY RESULTS
Children with perinatal HIV infection are at-risk for neuropsychological deficits, but few
studies have performed neuropsychological evaluation of African children across multiple
sites in resource-poor settings where children have received well-documented antiretroviral treatment and medical care and follow-up.
Principal study aims are:
1) To evaluate neuropsychological outcomes in perinatally HIV-infected (HIV), HIVuninfected perinatally-exposed (HEU), and HIV unexposed and uninfected (HUU)
children across 6 sub-Saharan sites in 4 countries.
2) Compare initial neuropsychological outcomes among HIV, HEU, and HUU children
across sites.
Weeks 0, 48 (blue, red) predicted standard scores (95% CI) on KABC and
TOVA by exposure group and study site
HIV, HEU, and
HUU
BetweenGroup
Comparisons
CONCLUSIONS
Test of Variables of Attention (TOVA)
Visual
Target
Non Target
HIV Disease Characteristics at 1104S study entry(N=246)
Characteristic
Age at ARV initiation, years
ARV Regimen
Years on ARVs
CD4%
HIV-1 RNA
Median (IQR range)
NRTI
NRTI+NNRTI
NRTI+PI
PI
Median (IQR range)
25% or higher
400 or less cp/ml
HIV (N=246)
1.2 (0.7, 2.1)
1 (0%)
78 (32%)
165 (67%
2 (1%)
5.9 (5.1, 6.8)
239 (97%)
235 (96%)
Presentation to the 8th Annual HIV Pediatrics Workshop:
Durban, RSA; 16-July-2016
Acknowledging the P1104s Study Teams and Leadership
E-mail: [email protected]
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