Director, Clinical Pharmacology
Reference 15-61
Posted December, 2015
About us:
At Arbutus, we have a vision: to cure chronic Hepatitis B virus (HBV). We have a dedicated and
innovative team and we are uniquely positioned to transform the HBV treatment landscape. We are
developing a portfolio of drug candidates with multiple mechanisms of action that we believe will result in
a combination therapy to cure HBV. Arbutus Biopharma has offices and research facilities in Burnaby,
Canada and Doylestown Pennsylvania, USA.
About the role:
Arbutus has an opportunity for a Director, Clinical Pharmacology to join our team. Reporting to the Chief
Medical Officer the Director, Clinical Pharmacology is responsible for the day-to-day management of
Arbutus Biopharma’s Clinical Pharmacology group.
If you are looking to join a team with a proven track record in drug discovery and development, and are as
passionate as we are, we want to hear from you.
Responsibilities will include:
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Assume strategic responsibility for the Clinical Pharmacology components of product development
from development candidate through lifecycle management post-approval
Design, plan, execute and report high quality Clinical Pharmacology studies, including PK, PK/PD,
DDI, special population studies in collaboration with Medical/Clinical operations, Translational
Research, Regulatory Affairs, Biostatistics and Research and Development colleagues
Share cross-functional responsibility for assessing safety, tolerability and pharmacokinetics in
clinical study participants.
Provide effective Clinical Pharmacology representation on Project teams and extra-departmental
activities
Contribute relevant clinical pharmacology content to Investigator brochures, clinical study
protocols, study reports annual reports and other related documents
Represent Arbutus in interactions with regulatory agencies and respond to regulatory inquiries
related to PK/PD and Clinical Pharmacology
Identify and manage consultants, vendors and CROs supporting Clinical Pharmacology
Participate in the evaluation of potential in-licensing candidates and contribute to responses to
relevant due diligence requests on Arbutus products
Other related duties as assigned
Qualifications:
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MD, PharmD or PhD in a related Life Sciences discipline and minimum 10 years’ experience in a
biopharmaceutical environment or equivalent combination of education and experience
Minimum 5 years of directly related experience in Clinical Pharmacology and PK/PD within drug
development at Pharma or Biotech
An experienced, hands-on manager, able to think creatively and strategically, while demonstrating
a bias for action
Exceptional written and verbal communication, presentation and negotiation skills
Expertise with standard modelling and simulation software (eg. NONMEM)
Expertise in other non-standard modelling software is an asset
Excellent interpersonal skills with a proven track record of building and maintaining strong
relationships with internal and external stakeholders
Sound judgment and excellent conflict resolution capabilities and an ability to react quickly to
changing needs
Contact Information:
100-8900 Glenlyon Parkway
Burnaby, BC V5J 5J8
e-mail: [email protected]
web: arbutusbio.com
How to Apply:
We invite you to send your cover letter and resume in PDF format, to [email protected]. Please
ensure your submission is in PDF format (ideally in one document) indicating your surname in the
filename (for example: SmithJane-cover-CV.pdf) and position title and reference number in the
subject line of the email (“Director, Clinical Pharmacology (15-61)”).
About your Application:
At Arbutus we value diversity and encourage applications from all qualified candidates.
We greatly appreciate your interest in being a part of our team; however, because of the volume of
resumes we receive, we are only able to contact you should you be considered for a position. We will
keep your resume in our database for one year, and contact you should a position that matches your
skills become available.