The Dolomite Centre Ltd
Dolomite Microfluidics – North America Office
Unit 1, Anglian Business Park, Orchard Road,
Royston, Hertfordshire, SG8 5TW, UK
Blacktrace Inc, 29 Albion Place
Charlestown, MA 02129, USA
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+44 (0)1763 242491
+44 (0)1763 246125
[email protected]
www.dolomite-microfluidics.com
617 803 6655
617 848 1121
617 500 0136
[email protected]
Membrane Chip Interface
and Accessories
product datasheet
Description
Main benefits
Specifications
Application 1: Liquid – Liquid Contacting
Application 2: Liquid – Liquid Separation
Application 3: Dead End Filtration
Application 4: Cross Flow Filtration
Application 5: Electrochemistry
Required Parts
Accessories
Facilitating equipment
Custom Chips and Membranes
The Dolomite Centre Limited
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Part name
Part number
Membrane Chip Interface
3200345
Membrane Chip
3200344
PTFE Membrane, Hydrophobic (Pack of 10)
3200343
PTFE Membrane, Hydrophilic (Pack of 10)
3200347
Description
The Membrane Chip Interface (Part No. 3200345) has been designed for in-line liquidliquid separation, liquid-liquid contacting, dead-end and cross flow filtration, and
electrochemistry. Set up is fast using standard 1/16” O.D. polymer tube, requiring no tools
or fittings.
The innovative interface allows good visibility of the chip and keeps the internal volume of
the system low with the tubes sealing directly to the chip.
The standard setup for operation includes a Membrane Chip Interface (Part No.
3200345), two Membrane Chips (Part No. 3200344), a PTFE Membrane, Hydrophobic
(Part No. 3200343) or a PTFE Membrane, Hydrophilic (Part No. 3200347).This setup can
be customised in various ways.
Left: Membrane Chip Interface (Part No.
3200345)
Above: Membrane Chip (Part No. 3200344)
and PTFE Membrane, Hydrophobic (Part No.
3200343)
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Main benefits
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Allows quick set-up of microfluidic experiments with membranes
Low dead volume
Fast set up times
Wide temperature and pressure range
Excellent chemical compatibility
Wide range of membranes possible
Optical access to membrane during experiments
Specifications
Specification
Value
Number of inputs
2
Number of outputs
2
Internal channel cross section
900µm x 150µm (width x depth)
Channel length
212mm
Membrane contact surface area
190mm2
Total internal volume
Flow rate raneg based on liquid - liquid
separation experiment
Surface roughness of channels (Ra)
56µl
Chip size
24mm x 24mm
Chip thickness
4mm
Operating pressure
0 - 10bar
Operating temperature
0 - 80°C
Chip material
Glass with PTFE (or other) membrane
Chip fabrication process
Wet etching
Chip sealing
Mechanical clamping, no adhesives
Up to 1.5ml/min*
5nm
* 1.5ml/min is based on carrying out a liquid-liquid separation between ethyl acetate and water, using a PTFE hydrophobic
membrane.
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Application 1: Liquid – Liquid Contacting
In this configuration separate organic and aqueous solvent streams can be brought into
contact across a membrane. This allows diffusion of solutes between the two streams.
The surface area of contact on the chip is 192mm2. See diagram below:
Organic solvent
stream
Aqueous solvent
stream
Application 2: Liquid – Liquid Separation
The liquid - liquid separation of immiscible organic and aqueous liquid streams can be
achieved with the set-up shown below.
The porous hydrophobic PTFE membrane repels the aqueous phase, but allows the
organic stream to pass through. This results in separation with the organic stream passing
out through the top chip and the aqueous stream passing out through the base chip as
shown below.
Hydrophilic porous membranes are also available, which results in the aqueous solvent
passing out of the top and the organic solvent passing out through the base.
Note: to achieve the maximum flow rate the cross-membrane pressure needs to be
controlled. One way to achieve this is to have a height difference between the output
streams.
Plug tubing
Flow stream with
immiscible organic
and aqueous
solvent phases
Organic solvent
stream
Aqueous
solvent stream
Membrane chip with porous PTFE membrane
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Application 3: Dead End Filtration
In this configuration an aqueous or organic solution, can be filtered trapping particulates
behind the membrane.
Plug tubing
Reagents stream
Filtered stream
Plug tubing
For example, precipitate can be collected during a precipitation reaction if the membrane
chip interface is situated downstream of the reaction process. We would recommend the
hydrophobic membrane for filtering organic solvents and the hydrophilic membrane for
filtering aqueous solvents.
Application 4: Cross Flow Filtration
In this configuration the solution is passed alongside the membrane so that filtered and
non-filtered streams are created. This set-up flushes away the retained particles
facilitating experiments which require a higher flow rate.
Plug tubing
Filtered stream
Reagents stream
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Application 5: Electrochemistry (Custom Setup)
In-flow electrochemistry is enabled by applying a voltage across the flow stream. This
type of reaction requires custom metal/carbon chips and a gasket so that the stream will
pass between the electrodes.
+V
Stream
Plug tubing
Plug tubing
-V
One or both chips may be wet etched or have machined channels. The electrical
connection (not supplied as standard) is applied with a spring contact through the viewing
window.
A set up involving multiple streams and a membrane is possible. Please contact us about
your requirements.
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Required Parts
In order to begin experimentation 2 x Membrane Chips (Part No. 3200344), the PTFE
Membrane, Hydrophobic (Part No. 3200343) or PTFE Membrane, Hydrophilic (Part No.
3200347), and the Membrane Chip Interface (Part No. 3200345) are required.
The Membrane Chip Interface (Part No. 3200345) includes the top and bottom of the
interface as well as FEP Tubing, 1/16" x 0.25mm, 10 metres (Part No. 3200063) and Plug
FEP (pack of 10) (Part No. 3000056) and four FFKM seals.
The Membrane Chip (Part No. 3200344) is a single 4mm thick glass layer with etched
channels on one surface. Two of these chips are required to carry out microfluidic
experiments (one to go above the membrane and one to go below the membrane).
Membrane Chip Interface (Part No. 3200345)
Chip Header FFKM Seal (Part No. 3000262)
(supplied with 3200345)
Membrane Chip (Part No. 3200344)
PTFE Membrane, Hydrophobic (Part No. 3200343) or
PTFE Membrane, Hydrophilic (Part No. 3200347)
Membrane Chip (Part No. 3200344)
Chip Header FFKM Seal (Part No. 3000262)
(supplied with 3200345)
Left: FEP Tubing, 1/16" x 0.25mm, 10 metres (Part No. 3200063)
Right: Plug FEP (pack of 10) (Part No. 3000056)
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Accessories and spares
Description
Part No.
PTFE Membrane, Hydrophobic (Pack of 10)
3200343
PTFE Membrane, Hydrophilic (Pack of 10)
3200347
Chip Header FFKM Seal (Pack of 10)
3000262
FEP Tubing, 1/16" x 0.25mm, 10 metres
3200063
Plug FEP (Pack of 10)
3000056
Facilitating equipment
Description
Part No.
Mitos Duo XS-Pump
3200057
Hotplate 230
3000223
Sample Injection Valve
3200037
T- Connector ETFE
3000397
Custom Chips and Membranes
Custom chips can be designed for the Membrane Chip Interface. It is also possible to use
different membranes and gaskets between the two glass layers. The clamping force
generated between the two glass layers is around 60kg.
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