The Antianginal Drug Trimetazidine Shifts Cardiac Energy
Metabolism From Fatty Acid Oxidation to Glucose
Oxidation by Inhibiting Mitochondrial Long-Chain 3Ketoacyl Coenzyme A Thiolase
by Paul F. Kantor, Arnaud Lucien, Raymond Kozak, and Gary D. Lopaschuk
Circulation Research
Volume 86(5):580-588
March 17, 2000
Copyright © American Heart Association, Inc. All rights reserved.
Effect of trimetazidine (1 μmol/L) on metabolic flux through glycolysis (A), glucose oxidation (B),
and fatty acid oxidation (C) in hearts perfused with 5 mmol/L glucose and 0.4 mmol/L palmitate
as substrate. *P<0.05 vs control. n=10 hearts in each group.
Paul F. Kantor et al. Circ Res. 2000;86:580-588
Copyright © American Heart Association, Inc. All rights reserved.
Effect of trimetazidine on metabolic flux through glycolysis (A) and glucose oxidation (B) in
ischemic hearts perfused with 5 mmol/L glucose and 0.4 mmol/L palmitate.
Paul F. Kantor et al. Circ Res. 2000;86:580-588
Copyright © American Heart Association, Inc. All rights reserved.
Effect of trimetazidine (1 μmol/L) on metabolic flux through glycolysis (A), glucose oxidation (B),
and fatty acid oxidation (C) in hearts perfused with 5 mmol/L glucose and 0.8 mmol/L octanoate
as substrate. n=10 hearts in each group.
Paul F. Kantor et al. Circ Res. 2000;86:580-588
Copyright © American Heart Association, Inc. All rights reserved.
Effect of trimetazidine (1 μmol/L) on metabolic flux through glycolysis (A), glucose oxidation (B),
and fatty acid oxidation (C) in hearts perfused with 5 mmol/L glucose and 1.6 mmol/L butyrate as
substrate. n=10 hearts in each group.
Paul F. Kantor et al. Circ Res. 2000;86:580-588
Copyright © American Heart Association, Inc. All rights reserved.
Direct effects of trimetazidine on rat heart mitochondrial short-chain (A), medium-chain (B), and
long-chain (C) 3-ketoacyl CoA thiolase.
Paul F. Kantor et al. Circ Res. 2000;86:580-588
Copyright © American Heart Association, Inc. All rights reserved.