Supplemental Table 2. Mean abundance values for Control sample and CD samples for
modules.
Module
Control
CD
M00178: Ribosome, bacteria
0.063828
0.045558
M00003: Gluconeogenesis, oxaloacetate => fructose-6P
0.056308
0.045490
M00002: Glycolysis, core module involving three-carbon
compounds
0.052032
0.041362
M00360: Aminoacyl-tRNA biosynthesis, prokaryotes
0.051746
0.039240
M00359: Aminoacyl-tRNA biosynthesis, eukaryotes
0.051437
0.038096
M00001: Glycolysis (Embden-Meyerhof pathway), glucose
=> pyruvate
0.050877
0.041484
M00051: Uridine monophosphate biosynthesis, glutamine
(+ PRPP) => UMP
0.042474
0.032198
M00007: Pentose phosphate pathway, non-oxidative phase,
fructose 6P => ribose 5P
0.041124
0.032771
M00125: Riboflavin biosynthesis, GTP =>
riboflavin/FMN/FAD
0.037631
0.029664
M00115: NAD biosynthesis, aspartate => NAD
0.031485
0.024999
M00222: Phosphate transport system
0.028742
0.022584
M00049: Adenine nucleotide biosynthesis, IMP =>
ADP/dADP,ATP/dATP
0.028254
0.025347
M00311: 2-oxoglutarate:ferredoxin oxidoreductase
0.028137
0.017464
M00050: Guanine nucleotide biosynthesis, IMP =>
GDP/dGDP,GTP/dGTP
0.027985
0.025623
M00022: Shikimate pathway, phosphoenolpyruvate +
erythrose-4P => chorismate
0.027259
0.023903
M00123: Biotin biosynthesis, pimeloyl-CoA => biotin
0.026642
0.022160
M00299: Spermidine/putrescine transport system
0.026227
0.022159
M00048: Inosine monophosphate biosynthesis, PRPP +
glutamine => IMP
0.023657
0.019745
M00026: Histidine biosynthesis, PRPP => histidine
0.023461
0.013647
M00018: Threonine biosynthesis, apartate => homoserine
=> threonine
0.022820
0.015463
M00126: Tetrahydrofolate biosynthesis, GTP => THF
0.021980
0.015370
M00004: Pentose phosphate pathway (Pentose phosphate
cycle)
0.021611
0.017978
M00016: Lysine biosynthesis, aspartate => lysine
0.021007
0.018595
M00017: Methionine biosynthesis, apartate => homoserine
=> methionine
0.020857
0.017943
M00127: Thiamine biosynthesis, AIR => thiamineP/thiamine-2P
0.018087
0.013162
M00157: F-type ATPase, bacteria
0.016089
0.015624
M00164: ATP synthase
0.016089
0.015624
M00006: Pentose phosphate pathway, oxidative phase,
glucose 6P => ribulose 5P
0.015437
0.013315
M00119: Pantothenate biosynthesis, valine/L-aspartate =>
pantothenate
M00239: Peptides/nickel transport system
M00207: Multiple sugar transport system
M00035: Methionine degradation
M00144: Complex I (NADH dehydrogenase), NADH
dehydrogenase I
M00133: Polyamine biosynthesis, arginine => agmatine =>
putrescine => spermidine
M00185: Sulfate transport system
M00064: ADP-L-glycero-D-manno-heptose biosynthesis
M00053: Pyrimidine deoxyribonuleotide biosynthesis,
CDP/CTP => dCDP/dCTP,dTDP/dTTP
M00237: Branched-chain amino acid transport system
M00324: Dipeptide transport system
M00300: Putrescine transport system
M00197: Putative sugar transport system
M00194: Maltose/maltodextrin transport system
M00124: Pyridoxal biosynthesis, erythrose-4P =>
pyridoxal-5P
M00276: PTS system, mannose-specific II component
M00061: Uronic acid metabolism
M00198: sn-Glycerol 3-phosphate transport system
M00348: Glutathione transport system
M00202: Oligogalacturonide transport system
M00121: Heme biosynthesis, glutamate =>
protoheme/siroheme
M00159: V-type ATPase, prokaryotes
M00028: Ornithine biosynthesis, glutamate => ornithine
M00045: Histidine degradation, histidine => Nformiminoglutamate => glutamate
M00096: C5 isoprenoid biosynthesis, non-mevalonate
pathway
M00019: Leucine biosynthesis, pyruvate => 2oxoisovalerate => leucine
M00025: Tyrosine biosynthesis, chorismate => tyrosine
M00245: Cobalt transport system
M00232: General L-amino acid transport system
M00193: Putative spermidine/putrescine transport system
M00336: Twin-arginine translocation (Tat) system
M00008: Entner-Doudoroff pathway, glucose-6P =>
glyceraldehyde-3P + pyruvate
M00009: Citrate cycle (TCA cycle, Krebs cycle)
M00011: Citrate cycle, second carbon oxidation
0.015400
0.013398
0.010426
0.009986
0.011134
0.017682
0.011656
0.005442
0.008482
0.004209
0.008150
0.006470
0.005673
0.007260
0.003681
0.007328
0.004677
0.004649
0.004113
0.003841
0.002987
0.002200
0.007321
0.005556
0.006926
0.004542
0.007875
0.006608
0.001581
0.001202
0.001172
0.000937
0.000553
0.000338
0.002221
0.007500
0.008119
0.007242
0.003000
0.000594
0.000122
0.000103
0.000088
0.003548
0.002302
0.006251
0.000085
0.001204
0.000075
0.008819
0.000013
0.000001
0.000001
0
0
0
0.004698
0.003585
0.001153
0.000752
0.001228
0.001140
0
0
0
0.001966
0.005482
0.005999
M00335: Sec (secretion) system
M00012: Glyoxylate cycle
M00277: PTS system, N-acetylgalactosamine-specific II
component
M00060: Lipopolysaccharide biosynthesis, KDO2-lipid A
M00150: Complex II (succinate dehydrogenase / fumarate
reductase), fumarate reductase
M00229: Arginine transport system
M00260: DNA polymerase III complex, bacteria
M00349: Microcin C transport system
M00230: Glutamate/aspartate transport system
M00117: Ubiquinone biosynthesis, prokaryotes, chorismate
=> ubiquinone
M00149: Complex II (succinate dehydrogenase / fumarate
reductase), succinate dehydrogenase
M00034: Methionine salvage pathway
0
0
0.001201
0.002516
0
0
0.000487
0.002570
0
0
0
0
0
0.003131
0.000841
0.002439
0.000604
0.000320
0
0.001696
0
0
0.001265
0.000440