New Product Innovation Leadership Award The Advanced Wound Care Industry EUROPE © Frost & Sullivan 1 “We Accelerate Growth” BEST PRACTICES RESEARCH Background and Company Performance Industry Challenges The European wound care market is in a steady growth stage. It is primarily driven by an increasingly aging population, as well as rising rates of diabetes and obesity. These chronic health problems lead to diabetic ulcers, venous leg ulcers, and major surgeries requiring advanced wound treatment products, thereby driving the growth of the wound care market. There are currently many wound treatment therapies available in the market, which include - but are not restricted to - ultrasound, shock therapy, and hyperbaric oxygen therapy. However, Frost & Sullivan notes that specific limitations of these treatment methods include slow healing rates, infection at the wound site, and potential pain. Lack of oxygen (hypoxia) is one of the main reasons for increased wound healing time. Additionally, these treatment options are quite expensive and can take a long time to carry through. Therefore, Frost & Sullivan feels that an innovative wound treatment product is required, one that is not only cost-effective, but also overcomes hypoxia, resulting in faster healing. Such treatments are likely to display promising potential in this market; Frost & Sullivan firmly believes that the company that truly offers such solutions is best positioned to effectively address the aforementioned market challenges and stay quite competitive in the market. Visionary Innovation and Product Excellence of Inotec AMD Product Matched to Market Needs One of the vital factors that determine the healing of wounds is the availability of oxygen at the site of repair. Hypoxia is one of the main reasons for increased time required for wound healing, as the damaged skin or the preexisting illness, such as diabetes, prevents sufficient oxygen from reaching the wound. It is estimated that, in Germany alone, around 4 million wounds per year stagnate in the process of healing - despite being treated according to gold standards for therapy. In line with this objective, Inotec AMD Ltd developed the NATROX™ device. NATROX™ works by supplying high concentrations of pure oxygen to the skin and wound bed under the dressing. This device creates an oxygen-enriched atmosphere at the wound area in order to accelerate the wound healing process. © Frost & Sullivan 2 “We Accelerate Growth” BEST PRACTICES RESEARCH Product Design NATROX™ is made up of two systems; The NATROX™ Oxygen Generator system extracts oxygen from the surrounding air, while the NATROX™ Oxygen Delivery System delivers this extracted oxygen through a flexible tube to the wounded area. The oxygen-rich environment makes oxygen easily available for the cells in the bed of the wound, thereby accelerating the healing process. NATROX™ is also light in weight, weighing only 107 grams, and its small size easily allows this device to be worn under clothing. Furthermore, this is a silent device and does not cause any sensation of movement, while nicely enabling a continuous flow of oxygen to the wound site. Enhanced Product/Service Value NATROX™ provides clear value to customers in terms of the increased time savings for healing wounds and the reduced risk of skin infection, which is quite expensive to treat. The shortening of the healing time reduces the expenses for dressing/wound care materials. In addition, it reduces the expenses for staff/nurses/caregivers, as the total number of dressing changes is reduced from the shortened healing time. Furthermore, oxygen radicals, resulting from increased molecular oxygen flow, perform the important job of killing bacteria, thereby reducing the chance of infection at the wound site. Strong Product Positioning One of the current trends constantly witnessed by Frost & Sullivan in the European wound care market is the shift in wound healing therapy from hospital/clinical settings to the home setting. In line with this, Inotec AMD Ltd designed the NATROX™. Unlike hyperbaric oxygen chambers, which are bulky and expensive, NATROX™ is a small portable device about the size of a mobile phone. Its light weight and small size allow it to be highly portable, thereby making it an ideal therapy device to be prescribed in homecare settings for the faster treatment of chronic wounds. Additionally, Inotec AMD has been recently (April, 2014) granted a research development contract from NHS England’s SBRI Healthcare programme. The objective of this research contract is to further investigate and develop the treatment of difficult to heal foot ulcers commonly suffered by diabetics by using Inotec AMD’s patented Natrox® system. All of these features and achievements render Natrox® system as an important and game changing solution in advanced wound care therapy. Superior Product Reliability and Quality A study conducted by the Wound Healing Centre on 10 patients using NATROX™ observed significant wound area reductions, along with a large reduction in pain, during the first 3 weeks of use. NATROX™ is a continuous therapy that allows the patient to remain fully © Frost & Sullivan 3 “We Accelerate Growth” BEST PRACTICES RESEARCH mobile while the device delivers sufficient quantities of oxygen to the wound bed to improve the healing process. This treatment differs from a hyperbaric chamber, in which the patient has to stay for some predetermined hours, usually with dressings removed so as to increase the diffusion. Both the NATROX™ Oxygen Generator system and the Oxygen Delivery System are CE approved. Responsiveness to Unmet Market Needs According to the International Diabetes Federation, the prevalence of diabetes was estimated to be 194 million around the world in 2012. It is expected to reach around 333 million by 2025, triggered by factors such as lifestyle, increased life expectancy rate, and changing dietary habits. It was also found that leg ulcers affect 0.5 to 1.5% of the entire adult population of Europe. Despite many treatment options, slow healing and increasing treatment costs frustrate end users. To combat these issues, Inotec AMD developed a superior solution in the market: the NATROX™ device. As previously mentioned, this solution helps create a continuous flow of pure humidified oxygen from the air to the wound site, thereby significantly accelerating healing time. Conclusion The European wound care market is recording steady growth. Companies in this sector report to Frost & Sullivan now they are constantly attempting develop products that are innovative and can effectively heal wounds. Inotec AMD was quick to recognize this trend and introduced NATROX™. As more than 90% of wounds suffer from a lack of oxygen, the launch of NATROX™ effectively addresses this serious concern with a simple, cost-effective, and highly efficient topical application of an advanced therapy. Treating a broad spectrum of primary diseases, including diabetic ulcers, ulcers with venous insufficiency, and pressure ulcers, Frost & Sullivan expects NATROX™ to be an integral part of any wound care regime in the coming years. In light of such initiatives and achievements, Inotec AMD has emerged as the worthy recipient of the 2014 Frost & Sullivan New Product Innovation Leadership Award. © Frost & Sullivan 4 “We Accelerate Growth” BEST PRACTICES RESEARCH Frost & Sullivan’s Global Research Platform Frost & Sullivan maintains more than 50 years in business and is a global research organization of 1,800 analysts and consultants who monitor more than 300 industries and 250,000 companies. The Company’s research philosophy originates with the CEO’s 360 Degree Perspective, a holistic research methodology that encourages us to consider growth challenges, and the solutions companies employ to solve them, from every angle. This unique approach enables us to determine how best-in-class companies worldwide manage growth, innovation and leadership. Based on the results of our research in new product innovation leadership, Frost & Sullivan is proud to present the 2014 European New Product Innovation Leadership Award in Advanced Wound Care market to Inotec AMD. Key Benchmarking Criteria For the New Product Innovation Leadership Award, Frost & Sullivan analysts independently evaluated the total client experience and strategy implementation excellence according to the criteria detailed below. Visionary Innovation Criterion 1: Unmet Needs Criterion 2: Use of Mega Trends Criterion 3: Pioneering Best Practices Criterion 4: Blue Ocean Strategy Criterion 5: Aspirational Ideals © Frost & Sullivan 5 “We Accelerate Growth” BEST PRACTICES RESEARCH Product Excellence Criterion 1: Match to Needs Criterion 2: Reliability and Quality Criterion 3: Product/Service Value Criterion 4: Positioning Criterion 5: Design The Intersection between 360-Degree Research and Best Practices Awards Research Methodology 360-DEGREE RESEARCH: SEEING ORDER IN THE CHAOS Frost & Sullivan’s 360-degree research methodology represents the analytical rigor of our research process. It offers a 360-degree-view of industry challenges, trends, and issues by integrating all 7 of Frost & Sullivan's research methodologies. Too often, companies make important growth decisions based on a narrow understanding of their environment, leading to errors of both omission and commission. Successful growth strategies are founded on a thorough understanding of market, technical, economic, financial, customer, best practices, and demographic analyses. The integration of these research disciplines into the 360-degree research methodology provides an evaluation platform for benchmarking industry players and for identifying those performing at bestin-class levels. Decision Support Scorecard and Matrix To support its evaluation of best practices across multiple business performance categories, Frost & Sullivan employs a customized Decision Support Scorecard and Matrix. This analytical tool compares companies’ performance relative to each other. It features criteria unique to each Award category and ranks importance by assigning weights to each criterion. The relative weighting reflects current market conditions and illustrates the associated importance of each criterion according to Frost & Sullivan. This tool allows our research and consulting teams to objectively analyze performance, according to each criterion, and to assign ratings on that basis. The tool follows a 10-point scale that allows for nuances in performance evaluation; ratings guidelines are illustrated below. © Frost & Sullivan 6 “We Accelerate Growth” BEST PRACTICES RESEARCH Best Practice Award Analysis for Inotec AMD Decision Support Scorecard: Visionary Innovation The Decision Support Scorecard illustrates the relative importance of each criterion and the ratings for each company under evaluation for the New Product Innovation Leadership Award. The research team confirms the veracity of the model by ensuring that small changes to the ratings for a specific criterion do not lead to a significant change in the overall relative rankings of the companies. Finally, to remain unbiased and to protect the interests of all organizations reviewed, we have chosen to refer to the other key players in as Company 2 and Company 3. DECISION SUPPORT SCORECARD FOR TECHNOLOGY INNOVATION LEADERSHIP AWARD (ILLUSTRATIVE): VISIONARY INNOVATION Measurement of 1–10 (1 = poor; 10 = excellent) Visionary Innovation Unmet Needs Use of Mega Trends Pioneering Best Practices Blue Ocean Strategy Aspirational Ideals Weighted Rating Award Criteria Relative Weight (%) 20% 20% 20% 20% 20% 100% Inotec AMD 9.0 9.0 9.0 9.0 10.0 9.2 Company 2 8.0 9.0 8.0 8.0 8.0 8.2 Company 3 8.0 8.0 8.0 7.0 8.0 7.8 Criterion 1: Unmet Needs Requirement: A clear understanding of customers’ desired outcomes, the products that currently help them achieve those outcomes, and where key gaps may exist © Frost & Sullivan 7 “We Accelerate Growth” BEST PRACTICES RESEARCH Criterion 2: Use of Mega Trends Requirement: Ability to incorporate long-range, macro-level scenarios into strategic plans, thereby anticipating and preparing for multiple futures that could occur Criterion 3: Pioneering Best Practices Requirement: A nothing-ventured-nothing-gained approach to strategy implementation that results in processes, tools, or activities that generate a consistent and repeatable level of success. Criterion 4: Blue Ocean Strategy Requirement: Proven track record of creating new demand in an uncontested market space, rendering the competition obsolete Criterion 5: Aspirational Ideals Requirement: A willingness to look beyond the simple goal of generating a profit to embrace a more powerful ideal of bringing greater value to customers or the planet Decision Support Scorecard: Product Excellence DECISION SUPPORT SCORECARD FOR PRODUCT LEADERSHIP AWARD (ILLUSTRATIVE): PRODUCT EXCELLENCE Measurement of 1–10 (1 = poor; 10 = excellent) Match to Needs Reliability and Quality Product/Service Value Positioning Design Weighted Rating Award Criteria Relative Weight (%) 20% 20% 20% 20% 20% 100% Inotec AMD 10.0 9.0 9.0 9.0 10.0 9.4 Company 2 9.0 8.0 9.0 8.0 9.0 8.6 Company 3 8.0 8.0 8.0 8.0 8.0 8.0 Product Excellence Criterion 1: Match to Needs Requirement: Customer needs directly influence and inspire a product’s design and positioning © Frost & Sullivan 8 “We Accelerate Growth” BEST PRACTICES RESEARCH Criterion 2: Reliability and Quality Requirement: The product consistently meets or exceeds customer expectations for performance and length of service Criterion 3: Product/Service Value Requirement: Products or services offer the best value for the price, compared to similar offerings in the market Criterion 4: Positioning Requirement: The product or service delivers a unique, unmet need that competitors cannot easily replicate or replace Criterion 5: Design Requirement: The product’s visual presentation makes it easy to use, and makes customers happy to use it © Frost & Sullivan 9 “We Accelerate Growth” BEST PRACTICES RESEARCH Decision Support Matrix Once all companies have been evaluated according to the Decision Support Scorecard, analysts can then position the candidates on the matrix shown below, enabling them to visualize which companies are truly breakthrough and which are not yet operating at bestin-class levels. © Frost & Sullivan 10 “We Accelerate Growth” BEST PRACTICES RESEARCH About Frost & Sullivan Frost & Sullivan, the Growth Partnership Company, enables clients to accelerate growth and achieve best in class positions in growth, innovation and leadership. 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