Synthesis and transfer of the LLO unit to a protein within the ER. The synthesis of the dolichol-coupled oligosaccharide complex (the lipid-linked
oligosaccharide, LLO) begins on the cytosolic face of the ER membrane. When the dolichol-sugar complex contains the initial 2 GlcNAc residues and
several mannose residues it is flipped such that the carbohydrate portion is moved to the luminal side of the ER membrane. Several more sugars are
added to form the complete LLO. The sugars portion of the LLO is then transferred to an appropriate Asn residue in an acceptor protein, leaving the
dolichol within the membrane. Reproduced with permission of the medical biochemistry page, LLC.
Source: Glycoproteins, Integrative Medical Biochemistry Examination and Board Review
Citation: King MW. Integrative Medical Biochemistry Examination and Board Review; 2014 Available at: http://mhmedical.com/ Accessed: July
31, 2017
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