Blood Compatibility and Anti-Fouling Capability of PEDOT-Graphene Oxide-Biopolymer
Derivatives Nanocomposites by Electro-Chemical Polymerization
Li-Ying Huang1, Ting-Yu Liu2*, Hui-Ming Tsou2, Che-Chun Liu2, Ming-Chien Yang1*
1
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei
10607, Taiwan; Email: [email protected]
2
Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan
Email: [email protected], web site: https://www.researchgate.net/profile/Ting_Yu_Liu
Poly(3,4-ethylenedioxythiophene) (PEDOT) nanocomposites and derivatives (graphene oxide (GO),
sodium dodecyl sulfate (SDS), polystyrene sulfonates (PSS), poly (diallyl-dimethylammonium chloride)
(PDDA), and heparin (HEP)) are fabricated by electro-chemical polymerization of EDOT monomers and
then coated on the SUS316 stainless steel with O2-plasma pretreatment. The characterizations of PEDOT
derivatives nanohybrids are evaluated by scanning electron microscopy (SEM), Fourier transform infrared
(FTIR) spectra, Raman spectroscopy, water contact angle, atomic force microscope (AFM), X-ray
diffractometer (XRD), and X-ray photoelectron spectroscopy (XPS). The results show that the great antifouling capability is observed in the PEDOT-SDS and PEDOT-GO-PDDA nanohybrids due to the strong
charge interaction between the positive charges of PEDOT-SDS/PEDOT-GO-PDDA, and the negative
charges of proteins and bacterial cell walls, measured by zeta potential. Furthermore, PEDOT-GO-HEP
shows the great anti-protein and anti-platelets capability, displaying superior blood compatibility. The novel
PEDOT-graphene oxide-biopolymer derivatives coating with great blood compatibility and anti-fouling
ability, are potential to apply in the biomedical materials coating, such as eluting stents, artificial fangs and
bones (Fig. 1) [1-3].
Fig1. Diagram of PEDOT-graphene oxide-biopolymer derivatives nanocomposites by electro-chemical polymerization
for eluting stents coating.
1. C.Z. Zhu, J.F. Zhai, D. Wen, and S. Dong. Journal of Materials Chemistry, 22, 6300 (2012)
2. C.H. Lu, Y.S. Hsiao, C.W. Kuo, and P. Chen, Biochimica et Biophysica Acta, 1830, 4321 (2013)
3. C. C. Liu, T. Y. Liu, K. S. Wang, H. M. Tsou, S. H. Wang, and J. S. Chen, Surface and Coatings
Technology, 303, 244 (2016)
Presentation Method (Poster/ Invited Oral 15/20/25/30 minutes): Poster