Journal of Injury and Inflammation http://jinjinf.com J Inj Inflamm. 2016;1(2):e07 Epidemiology and Prevention A short look to the most important medicinal plants effective on wound healing Mahmoud Bahmani1, Majid Asadi-Samani2* 1 2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran *Correspondence to Majid Asadi-Samani, Email: [email protected] Received 4 February 2016 Accepted 4 March 2016 Published online 10 March 2016 Citation: Bahmani M, Asadi-Samani M. A short look to the most important medicinal plants effective on wound healing. J Inj Inflamm.2016;1(2):e07. Core tip Various plants with wound-healing properties existed in different regions of Iran and may be administered for producing nature-based drugs after further investigations about these plants. Keywords: Medicinal plants, Wound, Fibronectin S kin wound is referred to the prolonged disruption of the structure of a body’s part because of the damage caused by various agents, including chemical, physical, and biological (1). Wound restoration is the restorative process taking place after the damage to skin and soft tissues. After damage, inflammatory response occurs and subdermal cells begin to increase the production of collagen and epithelial tissue is gradually restored (2). Fibronectin, an inhibitory factor for migration of macrophage, growth factors, matrix metaloproteinases, and hormones, is an effective factor on wound restoration (3,4). In Iranian traditional medicine, nature-based substances and medicinal plants are used to heal wounds. These pharmacologic resources are nature-based and easily available. The aim of this study is to report the medicinal plants used to heal wounds in different provinces of Iran. The native people of any regions empirically use the medicinal plants of their regions to heal wounds. For example, Fumaria vaillantii Loisel, and Heliotropium ramosissimum are used to heal wounds in Jandagh (5). In West Azarbaijan, Plantago major L. and Plantago lanceolata L., in Babol, Albizzia julibrissin Durazz, in Arasbaran region, Sambucus ebulus, Sambucus ebulus, Lamium album L., Lamium album L., Origanum vulgare, Rumex acetosa, Verbascum phlomoides, and Sanicula europaea, in Persian Gulf, Calotropis procera, Cressa cretica L., Ricinus communis, Prosopis farcta, and Ziziphus spinachirsti, in Khouzestan, Beta vulgaris L., Nerium indicum Mill., Carthamus tinetorius, and Echinops persicus, in Sistan, Aloe vera L., Medicago sativa L., Plantago lanceolata L., and Portulaca oleracea L., in Kazeroun, Fraxinus angustifolia, and Bromus tectorum L., in Mobarakeh (Isfahan province), Allium sativum L., Calendula persica, Mentha pulegium L., and Myrtus communis L., in Marivan (Kurdistan province), Quercus brantii Lindl., and Ranunculus sericeus Willd, in Natanz, Kashan, and in Ilam province, Nerium oleander L., Scrophularia deserti Del., Scrophularia striata Boiss., and Nerium oleander L. (6-15) are used to heal wounds. According to these findings, several plants with wound-healing properties existed in different regions of Iran and may be administered for producing nature-based drugs after further investigations about these plants. Authors’ contribution MB and MAS wrote the paper equally. Conflicts of interest The authors declared no competing interests. Ethical considerations The authors of this manuscript declare that they all have followed the ethical requirements for this communication. Also, Ethical issues (including plagiarism, data fabrication, double publication) have been completely observed by the authors. Funding/Support None. References 1. Johnston DE. Wound healing in skin, plastic Copyright © 2016 The Author(s); Published by Nickan Research Institute. 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