【附表 1】附表为常见的糖脂代谢通路主要蛋白，供参考。
糖代谢通路主要蛋白检测
序
号
蛋白名缩写
蛋白名全称
生物过程
1
Ins
Insulin
2
IR
Insulin receptor
3
p-IR
(Tyr1150/1151)
Phospho-insulin receptor (Tyr1150/1151)
4
p-IR (Tyr 1146)
Phospho-insulin receptor (Tyr 1146)
5
IGF1R（IR）
Insulin-like growth factor 1
6
CREB
cAMP response element-binding
p-CREB(Ser 133)
Phospho-cAMP response element-binding (Ser
133)
8
C/EBPα p42
CCAAT-enhancer-binding proteins p42
9
p-C/EBPα p42
Phospho- CCAAT-enhancer-binding proteins p42
10
p-p38 MAPK
Phospho-p38 mitogen-activated protein kinase
11
p44/42 MAPK
p44/42 mitogen-activated protein kinase
12
p-p44/42 MAPK
(Thr202/Tyr204)
Phospho-p44/42 mitogen-activated protein kinase
(Thr202/Tyr204)
13
p70s6k
p70S6 kinase
p-p70s6k
(Thr421/Ser424)
Phospho-p70S6 kinase
14
Akt
serine/threonine protein kinase
15
p- Akt (Ser473)
Phospho-serine/threonine protein kinase (Ser473)
16
p- Akt (Ser308)
Phospho-serine/threonine protein kinase (Ser308)
18
IRS
Insulin receptor substrate
19
p-IRS
Phospho- insulin receptor substrate
20
p-IRS (Ser 307)
Phospho- insulin receptor substrate (Ser 307)
21
Pten
phosphatase and tensin homolog
22
Socs1
suppressor of cytokine signaling proteins 1
23
Socs3
suppressor of cytokine signaling proteins 3
PGC-1α
peroxisome
proliferator-activated
coactivator-1α
25
PPARγ
peroxisome proliferator activated receptor gamma
26
PTP-1B
Protein tyrosine phosphatase-1B
27
UCP1
uncoupling protein 1
28
UCP2
uncoupling protein 2
29
AMPK
AMP-activated protein kinase
30
p-AMPK
Phospho- AMP-activated protein kinase
31
ACC
Acetyl-coA carboxylase
32
p- ACC
Phospho-Acetyl-coA carboxylase
7
17
24
receptor-γ
胰岛素信
号通路
33
34
35
GSK3β
glycogen synthase kinase 3 beta
36
p-GSK3β (Ser9)
Phospho-glycogen synthase kinase 3 beta (Ser9)
37
p-GSK3β
Phospho-glycogen synthase kinase 3 beta
38
Pdx-1
Pancreatic and duodenal homeobox 1
39
PI3K
Phosphatidylinositol 3-kinases
40
Sir2
silent information regulator 2
SIRT1
silent mating type information regulation 2
homolog 1
42
p-p90rsk(ser380)
Phospho-p90 ribosomal S6 kinase (ser380)
43
Pax-6
Paired box gene 6
44
Histone4(Ac16)
Histone 4 (Ac16)
45
Glycogen
Glycogen
46
Tubulin
Tubulin
47
Actin
Actin
48
Glut4
Glucose transporter type 4
41
其它
脂代谢通路主要蛋白检测
序
号
蛋白名缩写
蛋白名全称
1
Aacs
acetoacetyl-CoA synthetase
2
Aasdh
aminoadipate-semialdehyde dehydrogenase
3
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
Acaa2
acetyl-Coenzyme
A
acyltransferase
2
(mitochondrial 3-oxoacyl-Coenzyme A thiolase)
5
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
6
Acoxl
acyl-Coenzyme A oxidase-like
7
Adipor1
adiponectin receptor 1
8
Adipor2
adiponectin receptor 2
9
Apoa2
apolipoprotein A-II
10
Cpt1a
carnitine palmitoyltransferase 1a, liver
11
Cpt1b
carnitine palmitoyltransferase 1b, muscle
12
Cyb5
cytochrome b-5
Ehhadh
enoyl-Coenzyme A, hydratase/3-hydroxyacyl
Coenzyme A dehydrogenase
14
Faah
fatty acid amide hydrolase
15
Fabp2
fatty acid binding protein 2, intestinal
16
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
17
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
18
Lipa
lysosomal acid lipase A
19
Lipc
lipase, hepatic
20
Ppara
peroxisome proliferator activated receptor alpha
21
Ucp3
uncoupling protein 3 (mitochondrial, proton
4
13
生物过程
脂肪酸代
谢过程
carrier)
22
Acaa2
acetyl-Coenzyme
A
acyltransferase
2
(mitochondrial 3-oxoacyl-Coenzyme A thiolase)
23
Adipoq
adiponectin, C1Q and collagen domain containing
24
Ppard
peroxisome proliferator activator receptor delta
25
Apoa1
apolipoprotein A-I
26
Fdft1
farnesyl diphosphate farnesyl transferase 1
27
Fdps
farnesyl diphosphate synthetase
28
Pmvk
phosphomevalonate kinase
29
Acbd3
acyl-Coenzyme A binding domain containing 3
30
Cyp51
cytochrome P450, family 51
31
Hint2
histidine triad nucleotide binding protein 2
32
Lss
lanosterol synthase
33
Pbx1
pre B-cell leukemia transcription factor 1
34
Pmvk
phosphomevalonate kinase
35
Srd5a1
steroid 5 alpha-reductase 1
36
Srd5a2
steroid 5 alpha-reductase 2
37
Tspo
translocator protein
38
Srebf2
sterol regulatory element binding factor 2
脂肪酸β
氧化过程
胆固醇合
成过程
类固醇合
成
胆固醇代
谢过程