Hypothetical process of gene amplification in mammalian cells. It appears that several types of genetic abnormality are required to allow gene
amplification to take place. First, there needs to be loss of cell cycle control. Second, some mechanism of DNA damage or instability must occur. Finally,
there needs to be some stimulus to progress through the cell cycle. The events do not need to occur in this order, but the result is that cells progress
through the cell cycle with damaged DNA are unable to pause for proper repair. The net result is that gross genetic rearrangements can occur, leading to
amplification or other genetic rearrangements.
Source: Gene Amplification in Human Cancers: Biological and Clinical Significance, The Online Metabolic and Molecular Bases of Inherited
Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular
Bases of Inherited Disease; 2014 Available at: http://mhmedical.com/ Accessed: July 31, 2017
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