All new natural Anticoccidiostat
XTRTACT – C 6939
What is XTRACT-C?
XTRACT-C is…
Complex Additive composed of
Curcumin(Tumeric), Cavacrol, Capsaicin,
Cinnamaldehyde.
Four components have each stimulating
digestion enzyme activities, immune
responses, sterilization effects and
various biological effects.
Quality control of XTRACT
Pancosma is aware of the feed security stakes involved and has confined its
research in substances at a world-wide level in human and animal nutrition.
Moreover, all the active principles selected are classified by FDA
Name
CAS No
% in the composition
Tumeric oleoresin
8024-37-1
8
Cinnamaldehyde
104-55-2
1.2
Carvacrol
499-75-2
2
Capsicum oleoresin
8023-77-6
0.8
(Food&Drug Administration, USA) as GRAS (Generally Recognised As Safe).
Pancosma has anticipated in his research the principle of precaution.
Within this principle of global precaution. AXISS also includes the standardization
on active substances and the quality control. Nevertheless, wishing to reassuring
always more the consumer, Pancosma has undertaken a huge effort in the
quantitative and qualitative traceability of active substances in the animal
tissues
MODE OF ACTION
The effect of substances
What is CAPSAICIN?
Stimulating enzyme activities
• EFFECT OF CAPSAICIN IS TO STIMULATE PANCREATIC AND SMALL INTESTINE ENZYMES
CAPSAICIN
TRYPSIN
PROTEIN DIGESTION
AMYLASE
STARCH DIGESTION
LIPASE
FAT DIGESTION
The effect of substances
* Effect of Capsaicin in diets on the activity of pancreatic digestive enzymes
LIPASE
AMYLASE
TRYPSIN
CHYMOTRYPSIN
CONTROL
30.5
47.0
2.59
2.89
CAPSAICIN
41.4*
80.9*
5.70*
3.75*
* Effect of Capsaicin in diets on the activity of small intestine digestive enzymes
LIPASE
AMYLASE
SUCRASE
LACTASE
MALTASE
CONTROL
23.1
0.021
71.5
31.0
534.4
CAPSAICIN
67.2*
0.025*
98.6*
33.9
670.5*
Enzyme activity expressed in IU/ml
* Significantly higher than control (p<0.05).
Source : Platel and Srinivasan, Nahrung (2000) / Platel and Srinivasan, Int. J. Aliment Sci. (1996)
The effect of substances
CINNAMALDEHYDE : Anti-Oxidant
ACTIVITY OF MUCOSAL ANTIOXIDANT ENZYMES
CONTROL
CINNAMALDEHYDE
P
SUPEROXIDE
DISMUTASE
(IU/mg protein)
GLUTATHIONE
S-TRANSFERASE
(nmoles NADPH oxidised
/min/mg protein)
CATALASE
(mg x 10-3 mg protein)
9.4
3.6
64.0
15.8 *
4.5 *
88.8
0.05
0.05
NS
SOD expressed in IU/mg protein; GST expressed in nmoles NADPH oxidized/min/mg protein;
glutathione expressed in mg x 10-3 mg protein
* Significantly higher from control (p<0.05).
Source : JN Dhuley, Indian Journal of Experimental Biology, 37:23-42 (1999)
The effect of substances
CARVACROL: Stimulates Gram+, Lactic acid bacteria
(AT LOW PHYSIOLOGICAL LEVELS)
IN VITRO
LEVELS
POSSIBILITY
OF
RESISTANCE
CARVACROL
PHYSIOLOGICAL
LEVELS
Source : Kivanç et al., Int. J. Food Microbiol (1991)
Kills Gram- but also
Grma+ organism
including those in most
probiotic preparations
Stimulates Gram+
such as lactobacillus
and pediococcus
found in many
probiotic
preparations
The effect of substances
Tumeric/Curcumin : Biological effect
Enhance
Wound healing
Anti-inflammatory
Immunomodulatory
Anti-Oxidant activity
CH3O
OCH3
Anti-mutagenic
Prevents IRI/
Neuroprotection
HO
Anti-viral
Anti-fungal
Anti-bacteria
CH
CHCOCH2COCH
CH
Tumeric/Curcumin
OH
Anti-metastatic
Anti-angiogenic
The effect of substances

Phenols such as Carvacrol, Cinemaldehyde have been
proven to contain anticoccidial properties

Beside their phenolic mode of action against pathogenic
bacteria such as Clostridium perfringens they exert a
different mode of action against intracellular protozoanparasites such as Eimeria spp. - therefore to prevent and
treat coccidiosis and necrotic enteritis in poultry and swine.
The effect of substances

Phenols act on the gut lining (which is regularly shed in a
healthy intestinal mucosae) by increasing the rate of
nterocyte turnover by about 2x the normal rate (De asis
2002, Tsinas 1999, Ultee et al. 1999, Weber 1996).

The phenolic compounds disrupt the lifecycle of coccidian
parasites by speeding up the rate of shedding of the gut
lining – therefore intracellular coccidial sporozoites (which
multiply in the epithelial cells of the intestine) are shed
before they have the opportunity to penetrate deeper into
the gut wall or to form new oocysts (Tsinas et al. 1998,
Chapman 1988).
Trial Results
Anticoccidial effect of Xtract-C
By CP group in Thailands
Consumptions and Temperatures
Experimental context: 840 broilers SASSO 451 N nacked neck in “Label” conditions - 6 pens of 14
0 individus (70 males et 70 femelles) inoculated at 14 days per os with a dose of: 100000 oocystes of E.
acervulina, 10000 oocystes of E. tenella and 1000 oocystes of’E. maxima.
Source : ENSAT, France 2003.
Trial n° 03 COC 018
Live weight between 4 and 8 weeks in
comparison to monensin (CP group trial)
Experimental context: 840 broilers SASSO 451 N nacked neck in “Label” conditions - 6 pens of 14
0 individus (70 males et 70 femelles) inoculated at 14 days per os with a dose of: 100000 oocystes of E.
acervulina, 10000 oocystes of E. tenella and 1000 oocystes of’E. maxima.
6986 R&D at 500 ppm: weights near from monensin group
102%
100%
98%
Poids
27days27j
41days41j
Poids
55days55j
Poids
83days83j
Poids
96%
94%
92%
90%
88%
86%
Blank
blanc
Source : ENSAT, France 2003.
6986 375ppm 6986 500ppm
monensin
100 ppm
Trial n° 03 COC 018
Excretions ookystales fecales
Experimental context: 840 broilers SASSO 451 N nacked neck in “Label” conditions - 6 pens of 14
0 individus (70 males et 70 femelles) inoculated at 14 days per os with a dose of: 100000 oocystes of E.
acervulina, 10000 oocystes of E. tenella and 1000 oocystes of’E. maxima.
Faecal oocystes excreted at 21, 27, 41 et 70 days of age
6,00
6,00
blanc
Témoin
Blank
6986 375 ppm
6986 500 ppm
Monensin 100 ppm
ookystes en log10 /g de fientes
5,00
5,00
4,00
4,00
Decrease
oocyst
3,00
3,00
excretion
2,00
2,00
1,00
1,00
21
28
42
56
70
(jours)
âge days
Source : ENSAT, France 2003.
No statistics available
Trial n° 03 COC 018
Trial Results
Pathogenic bactericidial effect of Xtract-C
Essential Oils and Clostridium perfringens
- in feces
14
21
30 day
Figure 1.Relative frequencies of Clostridium perfringens concentrations per gram of sample in the feces of the control group © and
groups with essential oils blend A(thymol, eugenol, Curcumin, and piperin) and B(thymol, carvacrol, eugenol, curcumin, and piperin) on
d 14, 21, and 30.
2004 Poultry Science Association, Inc. Corresponding author : [email protected]
Essential Oils and Clostridium perfringens
- in jejunum
14
21
30 day
Figure 1.Relative frequencies of Clostridium perfringens concentrations per gram of sample in the jejunum of the control group © and
groups with essential oils blend A(thymol, eugenol, Curcumin, and piperin) and B(thymol, carvacrol, eugenol, curcumin, and piperin) on
d 14, 21, and 30.
2004 Poultry Science Association, Inc. Corresponding author : [email protected]
Dosage of XTRACT-C
Species
Dosage
Piglets
300 ~ 350g/ton
Grower pigs
150 ~ 200g/ton
Calves
250 ~ 300g/ton
Full-grown calf
150g/ton