Curriculum Vitae Personal Information Name: Xiaojiang Cui, PhD Research interests: breast cancer metastasis, targeted therapy, therapeutic resistance, cancer stem cells in breast cancer progression Academic Affiliations Department of Surgery Department of Obstetrics and Gynecology Women’s Cancer Program Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Contact Information 8700 Beverly Blvd West Tower, Suite 290 Los Angeles, CA 90048 Tel: 310-423-7437 (office), 310-423-7618 (laboratory), Fax: 310-423-9537 Email: [email protected] Education 1986-1990 1995-1999 East China University of Science and Technology, Shanghai, China, B.S., Biochemistry the University of Texas at Austin, Austin, TX, Ph.D., Molecular Biology Research and Teaching Experience 1990-1995 Research Scientist, Institute of Microbiology, the Chinese Academy of Sciences, Beijing, China 1995-1999 Teaching Assistant, the University of Texas at Austin, Austin, TX 2000-2003 Postdoctoral fellow, Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 2003-2007 Instructor, Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 2007-2011 Assistant Professor, Department of Molecular Oncology, John Wayne Cancer Institute, Saint John’s Health Center, Santa Monica, CA 2007-2011 Director, Translational Breast Research, John Wayne Cancer Institute, Saint John’s Health Center, Santa Monica, CA 2010-2011 Member, Saint John’s Health Center Cancer Committee, Santa Monica, CA 2010-2011 Maria Lim McClay Research Scholar, John Wayne Cancer Institute, Santa Monica, CA 2011-present Faculty Scientist II, Department of Surgery, Department of Obstetrics and Gynecology, Women’s Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 2012-present Associate Professor, Department of Surgery, Department of Obstetrics and Gynecology, Women’s Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 1 2013-present College Visiting Professor, Breast Surgery Hospital, Beijing, China Department, Peking Union Medical Awards 1988 Honor Student Award (one of five recipients in the university), East China University of Science and Technology, Shanghai, China 1990 Outstanding University Graduate Award, East China University of Science and Technology, Shanghai, China 1996 Tuition Fellowship Award, the University of Texas at Austin, Austin, TX 1997 Tuition Fellowship Award, the University of Texas at Austin, Austin, TX 1998 Professional Development Award, the University of Texas at Austin, Austin, TX 1999 The American Society of Plant Biologists annual meeting Travel Grant Award 2001 U.S. Department of Defense Breast Cancer Research Program Postdoctoral Training Award 2003 First Place Award of the abstract contest for the 1st Annual Dan L. Duncan Cancer Center Retreat and Symposium, Baylor College of Medicine and affiliated hospitals, Houston, TX 2004 Career Development Award, NIH/NCI Breast Cancer SPORE, Baylor College of Medicine, Houston, TX 2006 Presentation Award for the 2nd Annual Breast Program Retreat, Dan L. Duncan Cancer Center, Baylor College of Medicine and affiliated hospitals, Houston, TX 2009 Abstract Merit Award (fellow Partha Ray, MD), American Society of Clinical Oncology Annual Meeting, Orlando, FL 2009 Abstract Merit Award (fellow Partha Ray, MD), American Society of Clinical Oncology Breast Cancer Symposium, San Francisco, CA 2010 Abstract Merit Award (fellow Christopher Moran, MD), American Society of Clinical Oncology Gastrointestinal Cancers Symposium, San Francisco, CA 2011 Best Clinical Research Poster Award (fellow Christopher Moran, MD), Society of Surgical Oncology Annual Meeting, San Antonio, TX Professional Societies 2000-2004 Associate member of the American Association for Cancer Research 2000-2006 Associate member of the Endocrine Society 2004-present Active member of the American Association for Cancer Research 2006-present Active member of the Endocrine Society Journal Reviewer Annals of Surgical Oncology, Antioxidants & Redox Signaling, BMC Cancer, Breast Cancer Research and Treatment, Cancer Biology & Therapy, Cancer Chemotherapy and Pharmacology, Cancer Letters, Cancer Research, Cell Proliferation, Clinical Cancer Research, Current Molecular Medicine, Free Radical Biology and Medicine, FEBS Letters, Gynecologic Oncology, Histology and Histopathology, International Journal of Biomedical Science, International Journal of Biological Sciences, Journal of Cellular and Molecular Medicine, Journal of Experimental & Clinical Cancer Research, Molecular Cancer Therapeutics, Molecular Carcinogenesis, Molecular and Cellular Endocrinology, Tumor Biology International examiner for PhD dissertation, Monash University, Australia 2 Editorial Work Guest editor, journal Antioxidants & Redox Signaling (ISSN 1523-0864), special issue on Cell Growth and Metastasis, 2011 Reviewing editor, journal Antioxidants & Redox Signaling Editorial board member, Journal of Analytical Oncology (ISSN 1927-7229) Grant Review Ad Hoc reviewer for Breast Cancer Campaign, UK, 2004. Ad Hoc reviewer for the Health Research Board, Ireland, 2007. Member, PDF-Basic 6-Tumor Progression Review Panel, Susan G. Komen for the Cure, 2011. Member, Training-Pathobiology (TRN-PBY) peer review panel, Breast Cancer Research Program (BCRP), Department of Defense Congressionally Directed Medical Research Programs (CDMRP), 2011. Member, Investigator Initiated Research (IIR) Novel Therapeutics and Resistance – Targeted therapies for Triple-negative Breast Cancer Pre-application Peer Review Committee, Susan G. Komen for the Cure, 2011. Member, Training 2-Pathobiology (TRN2-PBY) peer review panel, Breast Cancer Research Program (BCRP), Department of Defense Congressionally Directed Medical Research Programs (CDMRP), 2012. Member, Training-Pathobiology (TRN-PBY) peer review panel, Breast Cancer Research Program (BCRP), Department of Defense Congressionally Directed Medical Research Programs (CDMRP), 2013. Member, Generic Cancer Panel (Investigator Initiated Research Projects and Innovative, Developmental or Exploratory Activities (IDEA) projects), the New York Stem Cell (NYSTEM) Science Program, 2013. Mentoring of Postdoctoral and Clinical Fellows Partha Ray (MD), University of Illinois at Urbana-Champaign Christopher Moran (MD), Oregon Health Science Center Jinghua Wang (PhD), John Wayne Cancer Institute Ying Qu (MD, PhD), Ruijin Hospital, Shanghai Second Medical University, China Sanjay Bagaria (MD), Mayo Clinic Jacksonville Bingchen Han (PhD), Cedars-Sinai Medical Center, current Yanli Jin (MD, PhD), Cedars-Sinai Medical Center, current Li Luo (MD, PhD), Cedars-Sinai Medical Center, current Alexandra Gangi (MD), resident, Cedars-Sinai Medical Center, current Tilley Jenkins Vogel (MD), Cedars-Sinai Medical Center, current Invited External Lectures and Talks 1. Annual Educational Evening, John Wayne Cancer Institute Auxiliary, Skirball Cultural Center, Los Angeles, CA, 2/25/2008. 2. Coffee Break Show, CityTV (Santa Monica, channel 16) and LA 36 (Los Angeles, channel 36), City Hall, Santa Monica, CA, 3/26/2008. 3. National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 4/29/2008. 3 4. State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, Shanghai, China, 5/4/2008. 5. BIT’s 3rd Annual World Cancer Congress -- Breast Cancer Conference, Shanghai, China, 4/2527/2010. 6. Breast Cancer Forum, Avon Foundation for Women, New York, NY, 3/1-2/2011. 7. The Saint John’s Health Center Foundation Board of Trustees annual “Chautauqua” retreat, the 20th Anniversary of the John Wayne Cancer Institute (JWCI) at Saint John’s, Ojai, CA, 4/23/2011. 8. University of Pittsburgh Cancer Institute, Magee Womens Research Institute, Pittsburgh, PA, 4/25/2011. 9. The Second Affiliated Hospital, Chongqing Medical School, Chongqing, China, 10/2011. 10. Western University of Health Sciences, College of Pharmacy, Pomona, CA, 11/13/2012. 11. Cancer Biology Program, Mayo Clinic, Jacksonville, Florida, 5/3/2013. 12. 2nd International Conference on Translational and Personalized Medicine, Chicago, IL, 8/57/2013. 13. 4th Annual World Congress of Molecular & Cell Biology, Tumor Invasion and Metastasis session chair, Dalian, China, 4/25-28/2014. Patent Applications 1. US patent, Methods for Diagnosis, Prognosis and Treatment of Primary and Metastatic Basal-like Breast Cancer and other Cancer Types, US Application No. 12/852,453, 8/6/2010. 2. US patent, FOXC1 antibodies and methods of their use, US Application No. 13/366,170, 2/3/2012. 3. Provisional application for US patent, Ovarian Cancer Gene Signature to Predict Outcome and Identify Therapeutic Targets. 8/28/2012 Publications 1. Huang W, Cui X, Peng X. Advances in plant anti-bacteria genetic engineering. Biotechnol Prog 13:17-19, 1993. 2. Cui X, Peng X, Zhou X, Mang K. Molecular analysis of transgenic potato expressing three virus coat protein genes. Chin Sci Bull 39:1992-1995, 1994. 3. Cui X, Peng X. Advances of plant genetic engineering in anti-microbial pathogens. Biodiversity Sci 2:96-102, 1994. 4. Cui X, Peng X, Shen Y, Mang K. Cloning and sequencing of PLRV coat protein gene and construction of vectors for transgenic potato resistant to co-infection of PVY, PVX and PLRV. Chin J Biotechnol 10:185-189, 1994. 5. Cui X, Peng X. Status and prospect of transgenic potato in China. Biodiversity Sci 2:72S-74S, 1994. 6. Cui X, Huang W, Liu Z, Peng X, Mang K. Expression of T7 lysozyme and its fusion proteins in Escherichia coli. Chin J Virol 10:178-183, 1994. 7. Song Y, Li C, Hou L, Zhang L, Ma Q, Peng X, Cui X, Zhou X, Wang H, Mang K. Construction of Plant Expression Vectors and Identification of Transgenic Potato Plants. J Integr Plant Biol 36:842-848, 1994. 8. Huang W, Cui X, Tian Y, Lin M, Peng X. Construction of the vector for transgenic plants resistant to bacterial infection. Acta Microbiologica Sinica 34:261-265, 1994. 4 9. Huang W, Cui X, Lin M, Peng X. Advances in the study of mycoplasma like organism. Microbiology 21:37-40, 1994. 10. Cui X, Liu Z, Tian Y, Peng X. Advances in the antibacterial peptide research and application prospect. Biochem Biophys Prog 22:5-8, 1995. 11. Xie A, Cui X, Song Y. Cloning and Sequencing of PHBb and PHBc in Alcaligenes eutrophus H16. J Integr Plant Biol 37:581-588, 1995. 12. Xiang Y, Yang L, Zhou X, Cui X, Peng X. Engineering resistance to PVY in transgenic tobacco expressing the PVY coat protein gene. Chin J Virol 11:158-162, 1995. 13. Zhang H, Peng X, Song Y, Li T, Meng Q, Liu C, Cui X. Resistance to mixed PVY and PLRV infection in potato cultivars expressing dual PVY and PLRV coat protein genes. J Integr Plant Biol 39:236-240, 1997. 14. Kimura S, Laosinchai W, Itoh T, Cui X, Linder CR, Brown RM. Immunogold labeling of rosette terminal cellulose-synthesizing complexes in the vascular plant vigna angularis. Plant Cell 11:2075-2086, 1999. 15. Cui X, Brown RM. Molecular cloning of a phospholipase D gene from cotton fibers. Plant Physiol. 120:PGR99-119, 1999. 16. Laosinchai W, Cui X, Brown RM. A full length cDNA of cotton cellulose synthase has high homology with the arabidopsis RSW1 gene and the cotton CelA1 gene. Plant Physiol. 122:PGR00-002, 2000. 17. Cui X, Shin H, Laosinchai W, Amano Y, Brown RM. A putative plant homolog of the yeast 1,3-glucan synthase subunit FKS1 from cotton fibers. Planta 213:223-230, 2001. 18. Lee AV, Cui X, Oesterreich S. Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer. Clin Cancer Res 7:4429S-4435S, 2001. 19. Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore AP, Streuli CH, Oesterreich S, Hadsell DL. New mechanisms of signal transduction inhibitor action: Receptor tyrosine kinase downregulation and blockade of signal transactivation. Clin Cancer Res 9:516S-523S, 2003. 20. Oesterreich S, Deng W, Jiang S, Cui X, Ivanova M, Schiff R, Kang K, Hadsell DL, Behrens J, Lee AV. Estrogen mediated E-cadherin downregulation in human breast cancer cells. Cancer Res 63:5203-5208, 2003. 21. Cui X, Zhang P, Deng W, Oesterreich S, Lu Y, Mills BG, Lee AV. IGF-I inhibits progesterone receptor expression in breast cancer cells via the PI3K/Akt/mTOR pathway: Progesterone receptor as a potential indicator of growth factor activity in breast cancer. Mol Endocrinol 17:575-588, 2003. 22. Cui X, Lazard Z, Zhang P, Hopp, Lee AV. Progesterone cross-talks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2. Oncogene 22:6937-6941, 2003. 23. Nakashima J, Laosinchai W, Cui X, Brown RM. New Insight into the Mechanism of Cellulose and Callose Biosynthesis: Proteases Regulate Callose Biosynthesis upon Wounding. Cellulose 10:369-389, 2003. 24. Cui X, Lee AV. Regulatory nodes that integrate and coordinate signaling as potential targets for breast cancer therapy. Clin Cancer Res 10:396S-401S, 2004. 25. Cui X, Schiff R, Arpino G, Osborne CK, Lee AV. The biology of progesterone loss in breast cancer and its implications for endocrine therapy. J Clin Oncol 23:7721-7735, 2005. 26. Cui X. Analysis of target gene transcription. In: Peng X, ed. Practical Methods in Plant Molecular Biology. Beijing, Chemical Industry Press; 282-291, 2005. 5 27. Kim H-J, Cui X, Hilsenbeck SG, Lee AV. Progesterone receptor loss correlates with HER-2 overexpression in estrogen receptor positive breast cancer. Clin Cancer Res 12:1013s-1018s, 2006. 28. Lee AV, Weiss H, Cui X, Osborne CK, Arpino G, Schiff R. In reply: Progesterone receptor in estrogen receptor-positive breast cancer: the association between HER-2 and lymph node involvement is age related. J Clin Oncol 24:2595-2597, 2006. 29. Cui X, Kim H-J, Kuiatse I, Lee AV. Epidermal Growth Factor Induces Insulin Receptor Substrate-2 in Breast Cancer Cells via JNK/AP-1 Signaling to Regulate Cell Migration. Cancer Res 66:5304-5313, 2006. 30. Dearth RK+, Cui X+ (+, co-first author), Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol 26:9302-9314, 2006. 31. Kim HJ, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X, Lewis MT, Gottardis MM, Wong TW, Attar RM, Carboni J, Lee AV. Constitutively active IGF-IR causes transformation and xenograft growth of immortalized mammary epithelial cells, and is accompanied by an epithelial to mesenchymal transition mediated by NF-kappaB and Snail. Mol Cell Biol 27:3165-3175, 2007. 32. Dearth RK, Cui X, Kim HJ, Hadsell D, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle 6:705-713., 2007. 33. Glaros S, Chinni SR, Cui X, Lee AV, Reddy KB. Isoform specific silencing of Akt-3 reduces cell motility and invasion in breast tumor cells. Int J Cancer, 2008. 34. Casa AJ, Dearth RK, Litzenburger BC, Lee AV, Cui X. The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance. Front Biosci 13:3273-3287, 2008. 35. Ibrahim YH, Byron SA, Cui X, Lee AV, Yee D. Progesterone receptor-B regulation of IGF stimulated cell migration in breast cancer cells via insulin receptor substrate-2 (IRS-2). Mol Cancer Res 6:1491-1498, 2008. 36. Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, Zhang F, Yu S, Stephens LC, Cui X, Murrow G, Coombes K, Muller W, Hung MC, Perou CM, Lee AV, Fang X, Mills GB. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell 15:539-550, 2009. 37. Wang J, Kuiatse I, Lee AV, Pan J, Giuliano A, Cui X. Wang J, Kuiatse I, Lee AV, Pan J, Giuliano A, Cui X. Wang J, Kuiatse I, Lee AV, Pan J, Giuliano A, Cui X. Sustained c-JunNH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation. Mol Cancer Res 8:266-277, 2010 (Highlights of the Issue). 38. Qu Y, Wang J, Liu B, Giuliano A, Barsoum J, Cui X. Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells. Breast Cancer Res Treat 121:311-321, 2010. 39. Ray PS, Wang J, Qu Y, Shin-Sim M, Shamonki J, Bagaria SP, Ye X, Liu B, Elashoff D, Hoon DSB, Giuliano AE, Cui X. FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res 70:3870-3876, 2010 (Cover of the Issue). 40. Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui X. Thioredoxin-like 2 regulates 6 human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. J Clin Invest 121:212-225, 2011 (Highlights of the Issue). 41. Bagaria SP, Ray PS, Wang J, Kropcho L, Chung A, Sim MS, Shamonki J, Martino S, Cui X+ (+, co-corresponding author), Giuliano AE. Prognostic value of basal phenotype in HER2overexpressing breast cancer. Ann Surg Oncol, 19:935-940, 2012. 42. Becker MA, Ibrahim YH, Cui X, Lee AV, Yee D. The insulin-like growth factor pathway regulates estrogen receptor alpha through a S6K1-dependent mechanism in breast cancer cells. Mol Endocrinol 25:516-528, 2011 (Translational highlights in J Clin Endocrinol Metab 96:872, 2011). 43. Ray PS, Bagaria SP, Wang J, Shamonki J, Ye X, Sim MS, Steen S, Qu Y, Cui X+ (+, cocorresponding author), Giuliano AE. Basal-like breast cancer defined by FOXC1 expression offers superior prognostic value: a retrospective immunohistochemical study. Ann Surg Oncol 18:3839-3847, 2011. 44. Cheng N-H, Zhang W, Chen W-Q, Jin J, Cui X, Butte NF, Chan L, Hirschi KD. A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J 278:2525-2539, 2011. 45. Han B, Yan J, Cui X. Biology of basal-like breast cancer. In: Schatten H, ed. Cell and Molecular Biology of Breast Cancer. Humana Press (Springer Science+Business Media LLC), 2013. 46. Cui X. Reactive oxygen species: the Achilles Heel of cancer cells? Antioxid Redox Signal, 16:1212-1214, 2012 (Forum Editorial). 47. Wang J, Qu Y, Ray PS, Sim MS, Zhou XZ, Lu KP, Liu B, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui X. FOXC1 orchestrates basal-like breast cancer cell functions by potentiating NF-B signaling. Oncogene 31:4798-4802, 2012. 48. Wang N, Cui X, Sun Z. The Molecular mechanism of ulinastatin as an inhibitor to the invasion and metastasis of human breast cancer cells. Chongqing Medicine 41:3023-3025, 2012. 49. Bagaria1 SP, Ray PS, Sim MS, Ye X, Shamonki JM, Cui X, Giuliano AE. Personalizing breast cancer staging by the inclusion of ER, PR, and HER2. JAMA Surg (in press), 2013. 50. Qu Y, Ray PS, Li J, Cai Q, Bagaria SP, Moran C, Sim MS, Zhang J, Turner RR, Zhu Z, Cui X, Liu B. High levels of sFRP1 correlate with poor prognosis and promote tumorigenesis in gastric cancer. Eur J Cancer (Epub ahead of print, Aug 5), 2013. 51. Chung A, Cui X, Audeh W, Giuliano A. Current status of anti-her2 therapies: predicting and overcoming Trastuzamab resistance. Clin Breast Cancer 13:223-232, 2013. 52. Wang L, Hou Y, Sun Y, Tang X, Hu P, Yang J, Zeng Z, Yang G, Cui X, Liu M. c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell invasion. Mol Oncol (in press), 2013. 53. Jin Y, Han B, Wiedemeyer R, Orsulic S, Bose S, Karlan BY, Giuliano AE, Cui X. FOXC1 is a critical mediator of EGFR function in cancer cells. J Clin Invest (submitted), 2013. 54. Cheng N, Qu Y, Cui X. Role of glutaredoxins in cancer development and metastasis. In: Stone B, ed. Free Radicals: The Role of Antioxidants and Pro-oxidants in Cancer Development. Nova Science Publishers, 2013. 55. Cheon D-J, Tong, Y, Sim M, Berel D, Cui X, Lester J, Tighiouart M, Walts, AE, Karlan B, Orsulic S. A collagen-remodeling gene signature regulated by TGFβ signaling is associated with metastasis and poor survival in serous ovarian cancer. Clin Cancer Res (revision under review), 2013. 7 56. Qu Y, Zhou C, Zhang J, Cai Q, Li J, Du T, Zhu Z, Cui X, Liu B. Metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer. Int J Oncol (submitted), 2013. 57. Three additional manuscripts in preparation. Meeting Presentations (unpublished) 1. LaPara KS, Cui X, Lee AV, Sachdev D, Yee D. Insulin-like growth factor I (IGF-I) does not stimulate growth in human breast cancer cells with constitutive activation of Akt3. The Endocrine Society 86th annual meeting, P3-176, 2004. 2. Ibrahim YH, Byron SA, Cui X, Lee AV, Yee D. IRS-2 mediates IGF-I induced cell motility in breast cancer cells. The Endocrine Society 86th annual meeting, P1-122, 2004. 3. Hadsell DL, Divisova J, Cui X, Lawrence NS, Lee AV. Mammary gland-specific overexpression of insulin receptor substrate-1 and -2 has minimal impact on downstream kinase activity and does not affect mammary gland involution. The Endocrine Society 86th annual meeting, P3-37, 2004. Funding Support Previous U.S. Department of Defense Breast Cancer Research Program Postdoctoral Fellowship Award DAMD17-01-1-0133, $150,000; 7/1/2001--6/30/2004. NIH/NCI SPORE P50 CA58183 Career Development Award, $160,000; 7/1/2004-6/30/2006. Susan G. Komen Breast Cancer Foundation Research Award BCTR0601346, $249,947; 5/1/06--4/30/09. Green Foundation Research Award, $32,000; 8/01/2008--7/31/2009. Del E. Webb Foundation Research Award, $50,000; 11/01/2009--10/31/2010. George I. Adler and Carole Zumbro Breast Cancer Research Award, $250,000; 1/1/2009-12/31/2010. Avon Foundation Research Award, 02-2008-081, $300,000; 1/1/2009--12/31/2010. Associates for Breast & Prostate Cancer Studies Research Award, $104,100; 9/1/2009-8/31/2011 Turning the Pumpkins Pink Breast Cancer Research Award, $37,322; 11/01/2010-10/30/2011. John Wayne Cancer Institute Maria Lim McClay Research Fund recipient, $50,000/y/5y, 2010. Fashion Footwear Association of New York Breast Cancer Research Award (project PI), $275,500; 05/19/2009--05/18/2011. UCLA Clinical & Translational Science Institute Core Voucher Award (NIH the National Center for Research Resources, UL1RR033176; the National Center for Advancing Translational Sciences, UL1TR000124), $4,400; 12/2011--02/2012. NIH/NCI, SBIR, HHSN261201100089C (Co-PI), $149,622; 9/15/11--6/14/12. Current Avon Foundation Research Award, 02-2010-068, $300,000; 7/01/2010--12/31/2013. NIH/NCI, RO1, CA151610, $1,934,000; 2/14/2011--1/31/2016. 8 David Salomon Translational Breast Cancer Research Fund, $200,000; 7/01/2012-6/30/2014. Pending NIH/NCI, RO1 (CA157854) NIH/NCI, R21 (CA173342) Avon Foundation Research Award 9
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