A1 A2 A3 A4 A5 B1 B2 B3 B4 B5 C1 C2 C3 C4 C5

fucose
fuc-L
atp
FK
adp
h
fuc1p-L
Fructose, mannose, and fucose metabolism
mannose
gtp
Galactose metabolism
Ascorbate Metabolism
man
gal
atp
atp
h
h2o
F1PGT
h2o
h
GDPFuc
GMAND
gdpddman
fructose
h
MAN1PT2
gdpmann
PMANM
man1p
f6p
MAN6PI
man6p
HEX7
DASCBH
ASCBOX
DOGULND1
SBTR
sbt-D
h
h
gal1p
udpg
UDPGlc
co2
atp
Ascorbate
DHA
lyxnt
glc-D
SBTD_D2
ascb-L
dhdascb
h
h
fru
pi
atp
h2o2
23doguln
nadph
nadp
adp
o2s
nad
atp
h
gdp
GDPMan
GFUCS
gdpfuc
nadh
adp
h
pi
h2o
DOGULND2
nadph
nadp
dopa
GALK
h
xylnt
ppi
DOPABMO
nrpphr
h2o
co2
HEX4
adp
o2
h2o2
h2o
GTHDH
h2o
pep
PFK26
ACNAM9PL2
h2o
utp
h
eryth
DASCBR
h
GALT
nadp
UGLT
utp
nadph
f26bp
GALU
UDPGP
UDPG4E
h
h2o
h
h
pi
ppi
h2o
gthox
DOGULNO1
DOGULNO2
adp
adp
h
gthrd
oxa
KHK
FBP26
h
ppi
f1p
oxa
kdnp
h
ump
thrnt
FBA2
g1p
h2o
udpgal
dhap
UDPGal
KDNH
ump@gD
glyald
pi
UDPGALtg
atp
kdn
TRIOK
KDN
ump
adp
h
udpgal@gD
g3p
glc-D@gD
g3p
UGALGTg
h@gD
udp@gD
A5
B5
Glycolysis
C5
Glycogen & Starch
D5
E5
lactose
lcts@gD
glc-D
GLCter
Glycogen biosynthesis
Glycogen degradation
Starch degrdation
atp
glc-D@rD
cbp@rD
glygn2@eD
strch1@eD
glygn2
Tyr-ggn
h@rD
pi@rD
h2o@eD
h2o@eD
udpg
pi
HEX1
AMY2e
AMY1e
GGNG
GLPASE1
glc-D@eD
CBPPer
G6PPer
h
g1p
udp
glygn4@eD
glc-D@eD
adp
dxtrn
co2@rD
nad@rD
nh4@rD
nadh@rD
h
nadph
h2o
O16G1e
h2o@eD
h@rD
h2o@rD
ggn
h2o@eD
strch2@eD
nadp
h
g6p@rD
G6PDH1rer
nad@rD
G6PDH2r
udp
PGL
PGI
G6PDH2rer
g1p
Pentose Phosphate Pathway
GLBRAN
GLPASE2
nadph@rD
f6p
nadp@rD
h@rD
pyr@mD
glycine
co2@rD
from glycogen breakdown, to nucleotide
6pgc
Tyr-ggn
From glucuronate degrdation
GNDer
h
h2o
malt@eD
From hydroxyproline degrdation
PGMT
glygn1
glygn3
GAMYe
Tyr-ggn@eD
nadp@rD
h@rD
h2o
h2o@eD
glc-D@eD
PGLer
nadh@rD
6pgl
glc-D
Glyoxylate metabolism
6pgc@rD
G6Pter
g6p
GLGNS1
h
glygn5@eD
h@rD
6pgl@rD
GLDBRAN
glc-D@eD
O16G2e
h2o@rD
G6PDH1er
udpg
gly
GLYtm
pi
GND
e4p
h2o@eD
glc-D
f6p
atp
g3p
f6p
FBP
atp
TKT1
GLXO1
h
adp
h
h2o
adp
atp
oxa@xD
xu1p-D
Di- and polysaccharide degradation
h
fdp
PPM
PRPPS
To nucleotide metabolism
h2o@xD
DRPA
g3p
tre@eD
malttr@eD
tre
malttr@lD
malttr
chtn@eD
h2o@eD
h2o
TREHe
drib
atp
CHTNASEe
nadp
glx@xD
AGTix
gly@xD
dhap
adp
h2o
FBA4
glyclt@mD
o2@xD
glycolate
o2@xD
glc-D@lD
glc-D
glc-D@eD
glc-D
GLYCTO1p
GLYCLTtp
glyclt@xD
glyc3p
malt@eD
GCALDD
hpyr
HPYRDC
gcald
h
nadph
PGLYCP
Ketogenesis
GCALDDm
glyclt@mD
pi
SPTix
nad
hpyr@mD
HPYRRy
co2@mD
nad@mD
h@mD
h@mD
nadp
co2@mD
h@mD
nadh@mD
h@mD
h@eD
h
h
GAPD
ser-L@xD
hpyr@xD
glyc-R
acetone
BDHm
bhb@mD
MALT
ADCim
acac@mD
glyc-S
ACETONEt2m
acetone@mD
acetone@eD
ACETONEt2
atp
h
MALTly
h
nadh
nadph
glc-D@eD
glc-D
GLYCK2
13dpg
glc-D@lD
o2
DPGM
Methylglyoxal metabolism
h
adp
ACTNMO
A4
B4
adp
h2o
C4
D4
h2o
23dpg
nadp
pi
nadp
nadph
ALR3
acetol
MGSA
dhap
ACYP
PGK
h
12ppd-S
h2o
h
L-1,2-propanediol
nadph
To glycolysis
pi
DPGase
nadp
pi
h
E4
2pg
atp
h
From glycolysis
3pg
nad
o2
Aminosugars Metabolism
MGSA2
g3p
pi
ACTLMO
nadp
ALR2
o2
h2o2
h2o
aact
gln-L
h2o@mD
mthgxl
glu-L
h
atp
adp
h
h
h
LALDO2x
nad
LALDD
LALDO2
ac
lac-D@mD
pep
LGTHL
gthrd
nadh
h
nadph
h2o
LDH_L
lac-L
nadh
acac
atp@mD
acald@eD
nad
UAGALDP
acgal
acgal1p
h2o
GalNAc
Ethanol
etoh@eD
ac@mD
ALDD2xm
ACSm
ppi@mD
oaa
h2o@mD
coa
h2o
cit@mD
h2o
h2o
ALDD2x
ALDD2y
CAT2p
etoh@xD
h2o2@xD
PPCOAOm
h
To nucleotide metabolism
fadh2@mD
2mcit
nadh@mD
acald@xD
icit@xD
h
nad@mD
icit@mD
h
h2o@xD
prpncoa@mD
MDHm
ACONTm
ACALDtx
Nucleotide Sugar Metabolism
h@mD
To lipid metabolism
nad
nadp
ManNAc
AMANK
MCITS
fad@mD
nad@mD
h@mD
nadp
o2
h2o
nadp@mD
oaa@mD
CSm
ETOHMO
nadph
udp
pi
ppcoa@mD
coa@mD
coa@mD
h
adp
amp@mD
atp@mD
nadh@mD
nad@mD
h@mD
atp
ME1m
ppi@mD
h2o@mD
ACCOAL
ppcoa
itp
h
ACS2
ppi
amp@mD
accoa@mD
h
acmana
ME2m
To lipid metabolism
nadph
coa
amp
co2@mD
h
ALCD2yf
atp
coa
ACCOALm
co2@mD
ACALDtm
atp
nadh@mD
acald@mD
acald
nadp
ppa@mD
nad@mD
ACALDt
ETOHt
ACGALK2
idp
UAG2EMAi
acgam
ppa
coa@mD
atp@mD
co2@mD
nadh@mD
udpacgal
nad
gtp@mD
pi@mD
h@mD
PCm
coa@mD
h
nadh
nad
etoh
UAG4E
adp@mD
hco3@mD
pyr@mD
PDHm
nadh
ALCD2if
h
h
h@mD
nadh@mD
LDH_Lm
h
ACGALK
UDP-GlcNAc
LDH_D
lac-D
atp
utp
h@mD
nad@mD
lac-L@mD
nadh@mD
nadph@mD
adp
ppi
nadh
PYRt2m
oaa@mD
h
UDP-GalNAc
accoa@mD
2hb
PEPCKm
h@mD
uacgam
fum
atp
2obut
h
h
L-LACtcm
LCADim
nadh
12ppd-R
ppi
coa
2HBO
nadh@mD
nad
nad@mD
gthrd
utp
UAGDP
AACOAT
gdp@mD
FUM
mal-L
LCADi_D
nadp
nad
MMSAD3m
h2o
ME2
pyr
h2o@mD
h
acgam1p
amp
nad
co2@mD
nad
adp
pyr
nadp
h
co2@mD
GLYOX
ACGAM2E
nadph co2
L-LACDcm
L-lactate
h
GlcNAc
nad
atp
lald-L@mD
ALCD21_DPPDOy
aacoa
ppi
nad@mD
h2o
ACGAMPM
atp
pep@mD
nadh
nadh
nadh
h
nad
h
h
nad
3hpp
coa@mD
MDH
focytC@mD
lgt-S
h2o
acgam6p
h
3HPPD
msa@mD
msa
h
PPDOx
gtp
co2
ficytC@mD
LALDO
h
gdp
PYK
lald-D
ACGAMK
h
h
h
nadh
Propanoate Metabolism
nadh
adp
LCADi
nad
coa
oaa
nadp
nadp
ACGAM6PSi AGDC
h
adp
pi
accoa
PEPCK
nadh
ALCD22_D
nad
ACITL
nadh@mD
gthrd
nadph
GlcN
gam
nadph
ac
h2o
gthrd@mD
nadph
CITL
h@mD
h@mD
h2o
HEX10
accoa
lald-L
ALCD22_L
h
nadh
gam6p
ENO
GLYOXm
LCADi_Dm
nad
nadh
methylglyoxal
h2o
atp
nadh
h
G6PDA
GF6PTA
akg
ICDHy
coa
2pg
nad@mD
h
AACTOOR
icit
ACONT
h2o@mD
h
nadp
nh4
cit
lald-D@mD lgt-S@mD
nadph
nh4
h2o
From glycine
co2
PGM
ALCD21_L
f6p
mal-L@mD
nadp@xD
nadp@mD
nadh
nadph
g1p
adp
h
h
acmanap
A3
FUMm
nad@mD
dttp
h
B3
h2o
h@eD
C3
ac
ACt2r
G1PTT
D3
ICDHyp
ac@eD
ICDHyrm
atp
pep
ICDHxm
coa
From nitrogen metabolism
TCA Cycle
coa
ACNAM9PL
Butanoate
but@mD
fum@mD
atp@mD
FACOAL40im
dtdpglu
ACS
pi
acnamp
nadph@xD
co2@mD
nadph@mD
ppi
h2o
ppi@mD
amp@mD
amp
TDPGDH
fadh2@mD
co2@xD
ACOAHi
h2o
E3
h2o@mD
coa@mD
h
ppi
ACNMLr
btcoa@mD
SUCD1m
fad@mD
co2@mD
ACNAMPH
nadh@mD
accoa
h2o
ACOAD1fm
fad@mD
akg@xD
pi
coa@mD
akg@mD
dtdp4d6dg
fadh2@mD
gtp@mD
b2coa@mD
Neu5Ac
acnam
h2o@mD
To nucleotide metabolism
acnam@nD
ACNAMtn
TDPDRE
ctp
succ@mD
3HBCDm
coa@mD
SUCOAS1m
ctp@nD
gdp@mD
dtdp4d6dm
CMPSAS
atp@mD
nad@mD
CMPSASn
SUCOASm
pi@mD
3hbcoa-R@mD
h
nadph
coa@mD
ppi@nD
ppi
co2@mD
TDPDRR
pi@mD
CMPACNAtn
cmpacna
AKGDm
nadp
cmpacna@nD
adp@mD
succoa@mD
dtdprmn
nadh@mD
CMP-Neu5Ac
Other Di- and Trisaccharides
tagat-D
lcts@eD
atp
lcts@lD
KHK3
h2o@eD
h2o@lD
SUCRe
LACZly
h
LACZe
tag1p-D
Pentose and glucuronate interconversions
glc-D@eD
glc-D@eD
udpg
atp@nD
FBA5
UDPGlc
pail_hs@nD
pail3p_hs@nD
ppmi12346p
ppmi12346p@nD
PIK3n
nad
glyald
PI3P3Pn
UDPGD
h2o@nD
ump
pi@nD
udpglcur@gD
udpxyl@gD
PI34P4Pn
PI3P4Kn
PIK4n
h2o@nD
adp@nD
h2o
PMI12346PH
PMI12346PHn
MI3456PK
adp
atp@nD
h@nD
atp@nD
UDPGlcA
udpglcur
h
pi@nD
atp@nD
ump@gD
UDPGLCAtg
pi
PI4P4Pn
adp@nD
h
pi@nD
PIK5n
h
adp@nD
h@nD
h
MI13456PK
minohp
PMI1346PH
mi13456p
GUR1PP
h2o@mD
pi
glcur
PMI1346PHn
atp@nD
MI13456Ptn
PI45P5Pn
PI4P5Kn
pi@nD
h2o@nD
adp@nD
h@nD
h2o@nD
h2o@nD
pi@nD
h@nD
atp@nD
atp@nD
C2
pail345p_hs@nD
h@nD
PI5P4Kn
PI345P3Pn
PI45P3Kn
glac@mD
glucarate
nad
h@nD
dag_hs@nD
glac@rD
GLACO
glcur@rD
adp@nD
adp@nD
Orphan Reactions
h@nD
nadph
h@rD
h
MI145P6Kn
PI45PLCn
atp
nadph@rD
MI1345PKn
gal
mi1346p
adp
GLRASE
atp@nD
nadp
PI5P4K
GULNDer
2mcacn
atp@nD
h
h
nadph
h2o
MICITDr
adp@nD
atp@nD
gullac
GALOR
nadp
h@nD
pi
h2o
nadp@rD
PI45P4P
GULLACter
h
mi1345p@nD
MI145PKn
mi145p@nD
h@rD
h2o@rD
gullac@rD
MI1346Ptn
h2o@nD
UROLACer
GLACter
h@nD
adp@nD
pi@nD
h2o
glac
glcr
h2o@nD
mi1346p@nD
atp@nD
h@nD
h@rD
MI1346PKn
mi13456p@nD
E2
atp@nD
h@nD
MI1456PKn
mi1456p@nD
GlcA
adp@nD
D2
pail5p_hs@nD
adp@nD
pail45p_hs@nD
GLCURter
h
h@nD
adp@nD
h@nD
B2
nad@mD
h2o@rD
nadh
ppmi1346p
pail4p_hs@nD
PI4P3Kn
PI34P3Pn
pi@nD
PI34P5Kn
PI345P5Pn
udp
adp@nD
glcr@mD
MINOHPtn
pi@nD
atp@nD
h
h2o
GLACOm
minohp@nD
h2o@nD
pail34p_hs@nD
UDPGNP
nadh@mD
h2o
pi
atp
ppmi1346p@nD
h@nD
h2o@nD
glcur1p
h@mD
atp@nD
h2o
ump
A2
adp
h
h@nD
h@nD adp@nD
UDPG1P
dhap
atp
pi@nD
nadh
h@gD
gal@eD
h2o
h2o@nD
h
UDPGLDCg
gal@lD
glc-D@lD
Inositol phosphate metabolism
mi3456p
h2o
co2@gD
galt
micit
adp
GLNLASEer
guln@rD
pi
h2o
dag_hs
PI345P3P
GULNter
gulonate
IP3
PI45PLC
MI145PK
atp
adp
mi1345p
mi145p
h
atp
h2o
h2o
adp
adp
MI134PK
h
h
PIP2
pail45p_hs
PI45P3K
h
h
nad
adp
atp
h2o
PIP3
pail345p_hs
pail5p_hs
guln
h2o
Itaconate & mesaconate metabolism
h2o
dag_hs@nD
GULN3D
PI4P5K
PI34P5KPI345P5P
h
PI45P5P
h@nD
pail4p_hs@nD
nadh
pi
pail5p_hs@rD
3dhguln
mi14p@nD
h2o
adp
PI5P3Ker
nadp
nad
xylulose
abt
ARABR
h
g6p
atp@rD
pi
h2o
ITCOALm
ITCOAL1m
h2o
adp@mD
MI14PP
MI14P4P
g6p
MI134PP
gdp@mD
pi@mD
pi@mD
MI1PS
atp
arab-L
pi
atp
pi
pi
itaccoa@mD
h2o
pail35p_hs@rD
adp
atp
h
pail3p_hs
pail35p_hs
nadph
h2o
PI4PP
PIK4
h@rD
adp@rD
h@rD
ABTD
dag_hs
From glycolysis
PI4P3Ker
PI3P4K
h2o
gtp@mD
atp@mD
h2o
pail4p_hs@rD
pail34p_hs@rD
adp
adp@rD
h
xylu-L
h
adp
nadph
h
h
adp
h
nadh
coa@mD
mi134p
PI4PLC
h
atp
atp@rD
DGULND
itacon@mD
coa@mD
mi14p
pail4p_hs
h
PI5P3K
PI35P3P
pi
MI14Ptn
PIP
PI4P3K
pail34p_hs
h
pi
PI4PLCn
atp
atp
atp
pi
MI1345PP
MI145PP
h2o@nD
pi
co2
PI3P5K
pail_hs
PIK3
PI
mi1p-D
PIPLC
XYLUR
atp
adp
h2o
h2o
pi
PI3PP
CITMCOAHm
MI134P4P
pi
dag_hs
h2o
MI1P-Dtn
nadp
h2o@mD
mi34p
mi4p-D
mi13p
MI13PP
h
h
citmcoa-L@mD
h2o
pi
xylt
pail_hs@nD
atp
adp
h2o
PIPLCn
PIK5
h
nad
MGACONm
MI4PP
MI1PP
h2o@nD
MI34PP
coa@mD
pi@mD
adp@rD
pi
cmp
h
mescoa@mD
pi
h
mescon@mD
pi@mD
pi
h2o
inost
cdpdag_hs
inositol
mi3p-D
MESCOALm
atp
INOSTO
accoa@mD
h
XYLK
h2o
pyr@mD
adp
B1
h
C1
glcur
xu5p-D
To glucuronate degradation
xylulose 5-phosphate
D1
coa@mD
atp@mD
h2o@mD
MI3PP
o2
MECOALm
adp@mD
accoa@mD
CDIPTr
MECOAS1m
CITMCOALm
pi
nadh
xylu-D
gtp@mD
gdp@mD
h2o@mD
dag_hs@nD
atp@rD
XYLTD_Dr
h2o
mi1p-D@nD
h@nD
pail_hs@rD
PIK3er
pail3p_hs@rD
h@rD
A1
sucr@eD
h2o@eD
adp
h@nD adp@nD
nad
HPYRtp
h@mD
nad@mD
h2o@lD
MALTe
nadh
HPYRR2x
h2o@mD
nadh@mD
2pglyc
HPYRDCm
gcald@mD
h2o
From fatty acid metabolism
malt@lD
malt
h2o
h2o@eD
hydroxypyruvate
h
pi
ala-L@xD
pyr@xD
TPI
acgam
co2
h2o
h
G3PD2m
CHTNASE
acgam@eD
nad
h
nadh
glyclt
g3p
glc-D@eD
From serine metabolism
dhap
nh4@xD
fad@mD
fadh2@mD
acald
MLTG1ly
MLTG1
MLTG1e
TREH
h2o@eD
h2o@lD
h2o
h2o2@xD
GLYOp
h2o2@xD
DRBK
2dr5p
chtn
h
h2o@eD
GLYCLTDy
h2o@xD
o2@xD
FBA
Chitin
nadp@mD
GLXtp
GLXO2p
r1p
prpp
Maltotriose
Trehalose
nadph
h2o2@xD
RBK
amp
h
GLYCLTDym
h
h@xD
GLYtp
rib-D
s7p
adp
nadph@mD
oxalate
RPI
r5p
atp
KHK2
glx
oxa
rbl-D
RBK_D
TALA
h@mD
h2o
h
ru5p-D
xu5p-D
RPE
e4p
GLXtm
nad
PFK
adp
h
glc-D@eD
atp
nadh
nadph
TKT2
xylu-D
AGTim
gly@mD
ru5p-D@rD
co2
MALTe
glyoxalate
glx@mD
nadph@rD
nadp
glygn2
ala-L@mD
E1
fru@eD
fucose
fuc-L
atp
FK
adp
h
fuc1p-L
Fructose, mannose, and fucose metabolism
mannose
gtp
Galactose metabolism
Ascorbate Metabolism
man
gal
atp
atp
h
h2o
F1PGT
h2o
h
GDPFuc
GMAND
gdpddman
fructose
h
MAN1PT2
gdpmann
PMANM
man1p
f6p
MAN6PI
man6p
HEX7
DASCBH
ASCBOX
DOGULND1
SBTR
sbt-D
h
h
gal1p
udpg
UDPGlc
co2
atp
Ascorbate
DHA
lyxnt
glc-D
SBTD_D2
ascb-L
dhdascb
h
h
fru
pi
atp
h2o2
23doguln
nadph
nadp
adp
o2s
nad
atp
h
gdp
GDPMan
GFUCS
gdpfuc
nadh
adp
h
pi
h2o
DOGULND2
nadph
nadp
dopa
GALK
h
xylnt
ppi
DOPABMO
nrpphr
h2o
co2
HEX4
adp
o2
h2o2
h2o
GTHDH
h2o
pep
PFK26
ACNAM9PL2
h2o
utp
h
eryth
DASCBR
h
GALT
nadp
UGLT
utp
nadph
f26bp
GALU
UDPGP
UDPG4E
h
h2o
h
h
pi
ppi
h2o
gthox
DOGULNO1
DOGULNO2
adp
adp
h
gthrd
oxa
KHK
FBP26
h
ppi
f1p
oxa
kdnp
h
ump
thrnt
FBA2
g1p
h2o
udpgal
dhap
UDPGal
KDNH
ump@gD
glyald
pi
UDPGALtg
atp
kdn
TRIOK
KDN
ump
adp
h
udpgal@gD
g3p
glc-D@gD
g3p
UGALGTg
h@gD
udp@gD
A5
B5
Glycolysis
C5
Glycogen & Starch
D5
E5
lactose
lcts@gD
glc-D
GLCter
Glycogen biosynthesis
Glycogen degradation
Starch degrdation
atp
glc-D@rD
cbp@rD
glygn2@eD
strch1@eD
glygn2
Tyr-ggn
h@rD
pi@rD
h2o@eD
h2o@eD
udpg
pi
HEX1
AMY2e
AMY1e
GGNG
GLPASE1
glc-D@eD
CBPPer
G6PPer
h
g1p
udp
glygn4@eD
glc-D@eD
adp
dxtrn
co2@rD
nad@rD
nh4@rD
nadh@rD
h
nadph
h2o
O16G1e
h2o@eD
h@rD
h2o@rD
ggn
h2o@eD
strch2@eD
nadp
h
g6p@rD
G6PDH1rer
nad@rD
G6PDH2r
udp
PGL
PGI
G6PDH2rer
g1p
Pentose Phosphate Pathway
GLBRAN
GLPASE2
nadph@rD
f6p
nadp@rD
h@rD
pyr@mD
glycine
co2@rD
from glycogen breakdown, to nucleotide
6pgc
Tyr-ggn
From glucuronate degrdation
GNDer
h
h2o
malt@eD
From hydroxyproline degrdation
PGMT
glygn1
glygn3
GAMYe
Tyr-ggn@eD
nadp@rD
h@rD
h2o
h2o@eD
glc-D@eD
PGLer
nadh@rD
6pgl
glc-D
Glyoxylate metabolism
6pgc@rD
G6Pter
g6p
GLGNS1
h
glygn5@eD
h@rD
6pgl@rD
GLDBRAN
glc-D@eD
O16G2e
h2o@rD
G6PDH1er
udpg
gly
GLYtm
pi
GND
e4p
h2o@eD
glc-D
f6p
atp
g3p
f6p
FBP
atp
TKT1
GLXO1
h
adp
h
h2o
adp
atp
oxa@xD
xu1p-D
Di- and polysaccharide degradation
h
fdp
PPM
PRPPS
To nucleotide metabolism
h2o@xD
DRPA
g3p
tre@eD
malttr@eD
tre
malttr@lD
malttr
chtn@eD
h2o@eD
h2o
TREHe
drib
atp
CHTNASEe
nadp
glx@xD
AGTix
gly@xD
dhap
adp
h2o
FBA4
glyclt@mD
o2@xD
glycolate
o2@xD
glc-D@lD
glc-D
glc-D@eD
glc-D
GLYCTO1p
GLYCLTtp
glyclt@xD
glyc3p
malt@eD
GCALDD
hpyr
HPYRDC
gcald
h
nadph
PGLYCP
Ketogenesis
GCALDDm
glyclt@mD
pi
SPTix
nad
hpyr@mD
HPYRRy
co2@mD
nad@mD
h@mD
h@mD
nadp
co2@mD
h@mD
nadh@mD
h@mD
h@eD
h
h
GAPD
ser-L@xD
hpyr@xD
glyc-R
acetone
BDHm
bhb@mD
MALT
ADCim
acac@mD
glyc-S
ACETONEt2m
acetone@mD
acetone@eD
ACETONEt2
atp
h
MALTly
h
nadh
nadph
glc-D@eD
glc-D
GLYCK2
13dpg
glc-D@lD
o2
DPGM
Methylglyoxal metabolism
h
adp
ACTNMO
A4
B4
adp
h2o
C4
D4
h2o
23dpg
nadp
pi
nadp
nadph
ALR3
acetol
MGSA
dhap
ACYP
PGK
h
12ppd-S
h2o
h
L-1,2-propanediol
nadph
To glycolysis
pi
DPGase
nadp
pi
h
E4
2pg
atp
h
From glycolysis
3pg
nad
o2
Aminosugars Metabolism
MGSA2
g3p
pi
ACTLMO
nadp
ALR2
o2
h2o2
h2o
aact
gln-L
h2o@mD
mthgxl
glu-L
h
atp
adp
h
h
h
LALDO2x
nad
LALDD
LALDO2
ac
lac-D@mD
pep
LGTHL
gthrd
nadh
h
nadph
h2o
LDH_L
lac-L
nadh
acac
atp@mD
acald@eD
nad
UAGALDP
acgal
acgal1p
h2o
GalNAc
Ethanol
etoh@eD
ac@mD
ALDD2xm
ACSm
ppi@mD
oaa
h2o@mD
coa
h2o
cit@mD
h2o
h2o
ALDD2x
ALDD2y
CAT2p
etoh@xD
h2o2@xD
PPCOAOm
h
To nucleotide metabolism
fadh2@mD
2mcit
nadh@mD
acald@xD
icit@xD
h
nad@mD
icit@mD
h
h2o@xD
prpncoa@mD
MDHm
ACONTm
ACALDtx
Nucleotide Sugar Metabolism
h@mD
To lipid metabolism
nad
nadp
ManNAc
AMANK
MCITS
fad@mD
nad@mD
h@mD
nadp
o2
h2o
nadp@mD
oaa@mD
CSm
ETOHMO
nadph
udp
pi
ppcoa@mD
coa@mD
coa@mD
h
adp
amp@mD
atp@mD
nadh@mD
nad@mD
h@mD
atp
ME1m
ppi@mD
h2o@mD
ACCOAL
ppcoa
itp
h
ACS2
ppi
amp@mD
accoa@mD
h
acmana
ME2m
To lipid metabolism
nadph
coa
amp
co2@mD
h
ALCD2yf
atp
coa
ACCOALm
co2@mD
ACALDtm
atp
nadh@mD
acald@mD
acald
nadp
ppa@mD
nad@mD
ACALDt
ETOHt
ACGALK2
idp
UAG2EMAi
acgam
ppa
coa@mD
atp@mD
co2@mD
nadh@mD
udpacgal
nad
gtp@mD
pi@mD
h@mD
PCm
coa@mD
h
nadh
nad
etoh
UAG4E
adp@mD
hco3@mD
pyr@mD
PDHm
nadh
ALCD2if
h
h
h@mD
nadh@mD
LDH_Lm
h
ACGALK
UDP-GlcNAc
LDH_D
lac-D
atp
utp
h@mD
nad@mD
lac-L@mD
nadh@mD
nadph@mD
adp
ppi
nadh
PYRt2m
oaa@mD
h
UDP-GalNAc
accoa@mD
2hb
PEPCKm
h@mD
uacgam
fum
atp
2obut
h
h
L-LACtcm
LCADim
nadh
12ppd-R
ppi
coa
2HBO
nadh@mD
nad
nad@mD
gthrd
utp
UAGDP
AACOAT
gdp@mD
FUM
mal-L
LCADi_D
nadp
nad
MMSAD3m
h2o
ME2
pyr
h2o@mD
h
acgam1p
amp
nad
co2@mD
nad
adp
pyr
nadp
h
co2@mD
GLYOX
ACGAM2E
nadph co2
L-LACDcm
L-lactate
h
GlcNAc
nad
atp
lald-L@mD
ALCD21_DPPDOy
aacoa
ppi
nad@mD
h2o
ACGAMPM
atp
pep@mD
nadh
nadh
nadh
h
nad
h
h
nad
3hpp
coa@mD
MDH
focytC@mD
lgt-S
h2o
acgam6p
h
3HPPD
msa@mD
msa
h
PPDOx
gtp
co2
ficytC@mD
LALDO
h
gdp
PYK
lald-D
ACGAMK
h
h
h
nadh
Propanoate Metabolism
nadh
adp
LCADi
nad
coa
oaa
nadp
nadp
ACGAM6PSi AGDC
h
adp
pi
accoa
PEPCK
nadh
ALCD22_D
nad
ACITL
nadh@mD
gthrd
nadph
GlcN
gam
nadph
ac
h2o
gthrd@mD
nadph
CITL
h@mD
h@mD
h2o
HEX10
accoa
lald-L
ALCD22_L
h
nadh
gam6p
ENO
GLYOXm
LCADi_Dm
nad
nadh
methylglyoxal
h2o
atp
nadh
h
G6PDA
GF6PTA
akg
ICDHy
coa
2pg
nad@mD
h
AACTOOR
icit
ACONT
h2o@mD
h
nadp
nh4
cit
lald-D@mD lgt-S@mD
nadph
nh4
h2o
From glycine
co2
PGM
ALCD21_L
f6p
mal-L@mD
nadp@xD
nadp@mD
nadh
nadph
g1p
adp
h
h
acmanap
A3
FUMm
nad@mD
dttp
h
B3
h2o
h@eD
C3
ac
ACt2r
G1PTT
D3
ICDHyp
ac@eD
ICDHyrm
atp
pep
ICDHxm
coa
From nitrogen metabolism
TCA Cycle
coa
ACNAM9PL
Butanoate
but@mD
fum@mD
atp@mD
FACOAL40im
dtdpglu
ACS
pi
acnamp
nadph@xD
co2@mD
nadph@mD
ppi
h2o
ppi@mD
amp@mD
amp
TDPGDH
fadh2@mD
co2@xD
ACOAHi
h2o
E3
h2o@mD
coa@mD
h
ppi
ACNMLr
btcoa@mD
SUCD1m
fad@mD
co2@mD
ACNAMPH
nadh@mD
accoa
h2o
ACOAD1fm
fad@mD
akg@xD
pi
coa@mD
akg@mD
dtdp4d6dg
fadh2@mD
gtp@mD
b2coa@mD
Neu5Ac
acnam
h2o@mD
To nucleotide metabolism
acnam@nD
ACNAMtn
TDPDRE
ctp
succ@mD
3HBCDm
coa@mD
SUCOAS1m
ctp@nD
gdp@mD
dtdp4d6dm
CMPSAS
atp@mD
nad@mD
CMPSASn
SUCOASm
pi@mD
3hbcoa-R@mD
h
nadph
coa@mD
ppi@nD
ppi
co2@mD
TDPDRR
pi@mD
CMPACNAtn
cmpacna
AKGDm
nadp
cmpacna@nD
adp@mD
succoa@mD
dtdprmn
nadh@mD
CMP-Neu5Ac
Other Di- and Trisaccharides
tagat-D
lcts@eD
atp
lcts@lD
KHK3
h2o@eD
h2o@lD
SUCRe
LACZly
h
LACZe
tag1p-D
Pentose and glucuronate interconversions
glc-D@eD
glc-D@eD
udpg
atp@nD
FBA5
UDPGlc
pail_hs@nD
pail3p_hs@nD
ppmi12346p
ppmi12346p@nD
PIK3n
nad
glyald
PI3P3Pn
UDPGD
h2o@nD
ump
pi@nD
udpglcur@gD
udpxyl@gD
PI34P4Pn
PI3P4Kn
PIK4n
h2o@nD
adp@nD
h2o
PMI12346PH
PMI12346PHn
MI3456PK
adp
atp@nD
h@nD
atp@nD
UDPGlcA
udpglcur
h
pi@nD
atp@nD
ump@gD
UDPGLCAtg
pi
PI4P4Pn
adp@nD
h
pi@nD
PIK5n
h
adp@nD
h@nD
h
MI13456PK
minohp
PMI1346PH
mi13456p
GUR1PP
h2o@mD
pi
glcur
PMI1346PHn
atp@nD
MI13456Ptn
PI45P5Pn
PI4P5Kn
pi@nD
h2o@nD
adp@nD
h@nD
h2o@nD
h2o@nD
pi@nD
h@nD
atp@nD
atp@nD
C2
pail345p_hs@nD
h@nD
PI5P4Kn
PI345P3Pn
PI45P3Kn
glac@mD
glucarate
nad
h@nD
dag_hs@nD
glac@rD
GLACO
glcur@rD
adp@nD
adp@nD
Orphan Reactions
h@nD
nadph
h@rD
h
MI145P6Kn
PI45PLCn
atp
nadph@rD
MI1345PKn
gal
mi1346p
adp
GLRASE
atp@nD
nadp
PI5P4K
GULNDer
2mcacn
atp@nD
h
h
nadph
h2o
MICITDr
adp@nD
atp@nD
gullac
GALOR
nadp
h@nD
pi
h2o
nadp@rD
PI45P4P
GULLACter
h
mi1345p@nD
MI145PKn
mi145p@nD
h@rD
h2o@rD
gullac@rD
MI1346Ptn
h2o@nD
UROLACer
GLACter
h@nD
adp@nD
pi@nD
h2o
glac
glcr
h2o@nD
mi1346p@nD
atp@nD
h@nD
h@rD
MI1346PKn
mi13456p@nD
E2
atp@nD
h@nD
MI1456PKn
mi1456p@nD
GlcA
adp@nD
D2
pail5p_hs@nD
adp@nD
pail45p_hs@nD
GLCURter
h
h@nD
adp@nD
h@nD
B2
nad@mD
h2o@rD
nadh
ppmi1346p
pail4p_hs@nD
PI4P3Kn
PI34P3Pn
pi@nD
PI34P5Kn
PI345P5Pn
udp
adp@nD
glcr@mD
MINOHPtn
pi@nD
atp@nD
h
h2o
GLACOm
minohp@nD
h2o@nD
pail34p_hs@nD
UDPGNP
nadh@mD
h2o
pi
atp
ppmi1346p@nD
h@nD
h2o@nD
glcur1p
h@mD
atp@nD
h2o
ump
A2
adp
h
h@nD
h@nD adp@nD
UDPG1P
dhap
atp
pi@nD
nadh
h@gD
gal@eD
h2o
h2o@nD
h
UDPGLDCg
gal@lD
glc-D@lD
Inositol phosphate metabolism
mi3456p
h2o
co2@gD
galt
micit
adp
GLNLASEer
guln@rD
pi
h2o
dag_hs
PI345P3P
GULNter
gulonate
IP3
PI45PLC
MI145PK
atp
adp
mi1345p
mi145p
h
atp
h2o
h2o
adp
adp
MI134PK
h
h
PIP2
pail45p_hs
PI45P3K
h
h
nad
adp
atp
h2o
PIP3
pail345p_hs
pail5p_hs
guln
h2o
Itaconate & mesaconate metabolism
h2o
dag_hs@nD
GULN3D
PI4P5K
PI34P5KPI345P5P
h
PI45P5P
h@nD
pail4p_hs@nD
nadh
pi
pail5p_hs@rD
3dhguln
mi14p@nD
h2o
adp
PI5P3Ker
nadp
nad
xylulose
abt
ARABR
h
g6p
atp@rD
pi
h2o
ITCOALm
ITCOAL1m
h2o
adp@mD
MI14PP
MI14P4P
g6p
MI134PP
gdp@mD
pi@mD
pi@mD
MI1PS
atp
arab-L
pi
atp
pi
pi
itaccoa@mD
h2o
pail35p_hs@rD
adp
atp
h
pail3p_hs
pail35p_hs
nadph
h2o
PI4PP
PIK4
h@rD
adp@rD
h@rD
ABTD
dag_hs
From glycolysis
PI4P3Ker
PI3P4K
h2o
gtp@mD
atp@mD
h2o
pail4p_hs@rD
pail34p_hs@rD
adp
adp@rD
h
xylu-L
h
adp
nadph
h
h
adp
h
nadh
coa@mD
mi134p
PI4PLC
h
atp
atp@rD
DGULND
itacon@mD
coa@mD
mi14p
pail4p_hs
h
PI5P3K
PI35P3P
pi
MI14Ptn
PIP
PI4P3K
pail34p_hs
h
pi
PI4PLCn
atp
atp
atp
pi
MI1345PP
MI145PP
h2o@nD
pi
co2
PI3P5K
pail_hs
PIK3
PI
mi1p-D
PIPLC
XYLUR
atp
adp
h2o
h2o
pi
PI3PP
CITMCOAHm
MI134P4P
pi
dag_hs
h2o
MI1P-Dtn
nadp
h2o@mD
mi34p
mi4p-D
mi13p
MI13PP
h
h
citmcoa-L@mD
h2o
pi
xylt
pail_hs@nD
atp
adp
h2o
PIPLCn
PIK5
h
nad
MGACONm
MI4PP
MI1PP
h2o@nD
MI34PP
coa@mD
pi@mD
adp@rD
pi
cmp
h
mescoa@mD
pi
h
mescon@mD
pi@mD
pi
h2o
inost
cdpdag_hs
inositol
mi3p-D
MESCOALm
atp
INOSTO
accoa@mD
h
XYLK
h2o
pyr@mD
adp
B1
h
C1
glcur
xu5p-D
To glucuronate degradation
xylulose 5-phosphate
D1
coa@mD
atp@mD
h2o@mD
MI3PP
o2
MECOALm
adp@mD
accoa@mD
CDIPTr
MECOAS1m
CITMCOALm
pi
nadh
xylu-D
gtp@mD
gdp@mD
h2o@mD
dag_hs@nD
atp@rD
XYLTD_Dr
h2o
mi1p-D@nD
h@nD
pail_hs@rD
PIK3er
pail3p_hs@rD
h@rD
A1
sucr@eD
h2o@eD
adp
h@nD adp@nD
nad
HPYRtp
h@mD
nad@mD
h2o@lD
MALTe
nadh
HPYRR2x
h2o@mD
nadh@mD
2pglyc
HPYRDCm
gcald@mD
h2o
From fatty acid metabolism
malt@lD
malt
h2o
h2o@eD
hydroxypyruvate
h
pi
ala-L@xD
pyr@xD
TPI
acgam
co2
h2o
h
G3PD2m
CHTNASE
acgam@eD
nad
h
nadh
glyclt
g3p
glc-D@eD
From serine metabolism
dhap
nh4@xD
fad@mD
fadh2@mD
acald
MLTG1ly
MLTG1
MLTG1e
TREH
h2o@eD
h2o@lD
h2o
h2o2@xD
GLYOp
h2o2@xD
DRBK
2dr5p
chtn
h
h2o@eD
GLYCLTDy
h2o@xD
o2@xD
FBA
Chitin
nadp@mD
GLXtp
GLXO2p
r1p
prpp
Maltotriose
Trehalose
nadph
h2o2@xD
RBK
amp
h
GLYCLTDym
h
h@xD
GLYtp
rib-D
s7p
adp
nadph@mD
oxalate
RPI
r5p
atp
KHK2
glx
oxa
rbl-D
RBK_D
TALA
h@mD
h2o
h
ru5p-D
xu5p-D
RPE
e4p
GLXtm
nad
PFK
adp
h
glc-D@eD
atp
nadh
nadph
TKT2
xylu-D
AGTim
gly@mD
ru5p-D@rD
co2
MALTe
glyoxalate
glx@mD
nadph@rD
nadp
glygn2
ala-L@mD
E1
fru@eD
fucose
fuc-L
atp
FK
adp
h
fuc1p-L
Fructose, mannose, and fucose metabolism
mannose
gtp
Galactose metabolism
Ascorbate Metabolism
man
gal
atp
atp
h
h2o
F1PGT
h2o
h
GDPFuc
GMAND
gdpddman
fructose
h
MAN1PT2
gdpmann
PMANM
man1p
f6p
MAN6PI
man6p
HEX7
DASCBH
ASCBOX
DOGULND1
SBTR
sbt-D
h
h
gal1p
udpg
UDPGlc
co2
atp
Ascorbate
DHA
lyxnt
glc-D
SBTD_D2
ascb-L
dhdascb
h
h
fru
pi
atp
h2o2
23doguln
nadph
nadp
adp
o2s
nad
atp
h
gdp
GDPMan
GFUCS
gdpfuc
nadh
adp
h
pi
h2o
DOGULND2
nadph
nadp
dopa
GALK
h
xylnt
ppi
DOPABMO
nrpphr
h2o
co2
HEX4
adp
o2
h2o2
h2o
GTHDH
h2o
pep
PFK26
ACNAM9PL2
h2o
utp
h
eryth
DASCBR
h
GALT
nadp
UGLT
utp
nadph
f26bp
GALU
UDPGP
UDPG4E
h
h2o
h
h
pi
ppi
h2o
gthox
DOGULNO1
DOGULNO2
adp
adp
h
gthrd
oxa
KHK
FBP26
h
ppi
f1p
oxa
kdnp
h
ump
thrnt
FBA2
g1p
h2o
udpgal
dhap
UDPGal
KDNH
ump@gD
glyald
pi
UDPGALtg
atp
kdn
TRIOK
KDN
ump
adp
h
udpgal@gD
g3p
glc-D@gD
g3p
UGALGTg
h@gD
udp@gD
A5
B5
Glycolysis
C5
Glycogen & Starch
D5
E5
lactose
lcts@gD
glc-D
GLCter
Glycogen biosynthesis
Glycogen degradation
Starch degrdation
atp
glc-D@rD
cbp@rD
glygn2@eD
strch1@eD
glygn2
Tyr-ggn
h@rD
pi@rD
h2o@eD
h2o@eD
udpg
pi
HEX1
AMY2e
AMY1e
GGNG
GLPASE1
glc-D@eD
CBPPer
G6PPer
h
g1p
udp
glygn4@eD
glc-D@eD
adp
dxtrn
co2@rD
nad@rD
nh4@rD
nadh@rD
h
nadph
h2o
O16G1e
h2o@eD
h@rD
h2o@rD
ggn
h2o@eD
strch2@eD
nadp
h
g6p@rD
G6PDH1rer
nad@rD
G6PDH2r
udp
PGL
PGI
G6PDH2rer
g1p
Pentose Phosphate Pathway
GLBRAN
GLPASE2
nadph@rD
f6p
nadp@rD
h@rD
pyr@mD
glycine
co2@rD
from glycogen breakdown, to nucleotide
6pgc
Tyr-ggn
From glucuronate degrdation
GNDer
h
h2o
malt@eD
From hydroxyproline degrdation
PGMT
glygn1
glygn3
GAMYe
Tyr-ggn@eD
nadp@rD
h@rD
h2o
h2o@eD
glc-D@eD
PGLer
nadh@rD
6pgl
glc-D
Glyoxylate metabolism
6pgc@rD
G6Pter
g6p
GLGNS1
h
glygn5@eD
h@rD
6pgl@rD
GLDBRAN
glc-D@eD
O16G2e
h2o@rD
G6PDH1er
udpg
gly
GLYtm
pi
GND
e4p
h2o@eD
glc-D
f6p
atp
g3p
f6p
FBP
atp
TKT1
GLXO1
h
adp
h
h2o
adp
atp
oxa@xD
xu1p-D
Di- and polysaccharide degradation
h
fdp
PPM
PRPPS
To nucleotide metabolism
h2o@xD
DRPA
g3p
tre@eD
malttr@eD
tre
malttr@lD
malttr
chtn@eD
h2o@eD
h2o
TREHe
drib
atp
CHTNASEe
nadp
glx@xD
AGTix
gly@xD
dhap
adp
h2o
FBA4
glyclt@mD
o2@xD
glycolate
o2@xD
glc-D@lD
glc-D
glc-D@eD
glc-D
GLYCTO1p
GLYCLTtp
glyclt@xD
glyc3p
malt@eD
GCALDD
hpyr
HPYRDC
gcald
h
nadph
PGLYCP
Ketogenesis
GCALDDm
glyclt@mD
pi
SPTix
nad
hpyr@mD
HPYRRy
co2@mD
nad@mD
h@mD
h@mD
nadp
co2@mD
h@mD
nadh@mD
h@mD
h@eD
h
h
GAPD
ser-L@xD
hpyr@xD
glyc-R
acetone
BDHm
bhb@mD
MALT
ADCim
acac@mD
glyc-S
ACETONEt2m
acetone@mD
acetone@eD
ACETONEt2
atp
h
MALTly
h
nadh
nadph
glc-D@eD
glc-D
GLYCK2
13dpg
glc-D@lD
o2
DPGM
Methylglyoxal metabolism
h
adp
ACTNMO
A4
B4
adp
h2o
C4
D4
h2o
23dpg
nadp
pi
nadp
nadph
ALR3
acetol
MGSA
dhap
ACYP
PGK
h
12ppd-S
h2o
h
L-1,2-propanediol
nadph
To glycolysis
pi
DPGase
nadp
pi
h
E4
2pg
atp
h
From glycolysis
3pg
nad
o2
Aminosugars Metabolism
MGSA2
g3p
pi
ACTLMO
nadp
ALR2
o2
h2o2
h2o
aact
gln-L
h2o@mD
mthgxl
glu-L
h
atp
adp
h
h
h
LALDO2x
nad
LALDD
LALDO2
ac
lac-D@mD
pep
LGTHL
gthrd
nadh
h
nadph
h2o
LDH_L
lac-L
nadh
acac
atp@mD
acald@eD
nad
UAGALDP
acgal
acgal1p
h2o
GalNAc
Ethanol
etoh@eD
ac@mD
ALDD2xm
ACSm
ppi@mD
oaa
h2o@mD
coa
h2o
cit@mD
h2o
h2o
ALDD2x
ALDD2y
CAT2p
etoh@xD
h2o2@xD
PPCOAOm
h
To nucleotide metabolism
fadh2@mD
2mcit
nadh@mD
acald@xD
icit@xD
h
nad@mD
icit@mD
h
h2o@xD
prpncoa@mD
MDHm
ACONTm
ACALDtx
Nucleotide Sugar Metabolism
h@mD
To lipid metabolism
nad
nadp
ManNAc
AMANK
MCITS
fad@mD
nad@mD
h@mD
nadp
o2
h2o
nadp@mD
oaa@mD
CSm
ETOHMO
nadph
udp
pi
ppcoa@mD
coa@mD
coa@mD
h
adp
amp@mD
atp@mD
nadh@mD
nad@mD
h@mD
atp
ME1m
ppi@mD
h2o@mD
ACCOAL
ppcoa
itp
h
ACS2
ppi
amp@mD
accoa@mD
h
acmana
ME2m
To lipid metabolism
nadph
coa
amp
co2@mD
h
ALCD2yf
atp
coa
ACCOALm
co2@mD
ACALDtm
atp
nadh@mD
acald@mD
acald
nadp
ppa@mD
nad@mD
ACALDt
ETOHt
ACGALK2
idp
UAG2EMAi
acgam
ppa
coa@mD
atp@mD
co2@mD
nadh@mD
udpacgal
nad
gtp@mD
pi@mD
h@mD
PCm
coa@mD
h
nadh
nad
etoh
UAG4E
adp@mD
hco3@mD
pyr@mD
PDHm
nadh
ALCD2if
h
h
h@mD
nadh@mD
LDH_Lm
h
ACGALK
UDP-GlcNAc
LDH_D
lac-D
atp
utp
h@mD
nad@mD
lac-L@mD
nadh@mD
nadph@mD
adp
ppi
nadh
PYRt2m
oaa@mD
h
UDP-GalNAc
accoa@mD
2hb
PEPCKm
h@mD
uacgam
fum
atp
2obut
h
h
L-LACtcm
LCADim
nadh
12ppd-R
ppi
coa
2HBO
nadh@mD
nad
nad@mD
gthrd
utp
UAGDP
AACOAT
gdp@mD
FUM
mal-L
LCADi_D
nadp
nad
MMSAD3m
h2o
ME2
pyr
h2o@mD
h
acgam1p
amp
nad
co2@mD
nad
adp
pyr
nadp
h
co2@mD
GLYOX
ACGAM2E
nadph co2
L-LACDcm
L-lactate
h
GlcNAc
nad
atp
lald-L@mD
ALCD21_DPPDOy
aacoa
ppi
nad@mD
h2o
ACGAMPM
atp
pep@mD
nadh
nadh
nadh
h
nad
h
h
nad
3hpp
coa@mD
MDH
focytC@mD
lgt-S
h2o
acgam6p
h
3HPPD
msa@mD
msa
h
PPDOx
gtp
co2
ficytC@mD
LALDO
h
gdp
PYK
lald-D
ACGAMK
h
h
h
nadh
Propanoate Metabolism
nadh
adp
LCADi
nad
coa
oaa
nadp
nadp
ACGAM6PSi AGDC
h
adp
pi
accoa
PEPCK
nadh
ALCD22_D
nad
ACITL
nadh@mD
gthrd
nadph
GlcN
gam
nadph
ac
h2o
gthrd@mD
nadph
CITL
h@mD
h@mD
h2o
HEX10
accoa
lald-L
ALCD22_L
h
nadh
gam6p
ENO
GLYOXm
LCADi_Dm
nad
nadh
methylglyoxal
h2o
atp
nadh
h
G6PDA
GF6PTA
akg
ICDHy
coa
2pg
nad@mD
h
AACTOOR
icit
ACONT
h2o@mD
h
nadp
nh4
cit
lald-D@mD lgt-S@mD
nadph
nh4
h2o
From glycine
co2
PGM
ALCD21_L
f6p
mal-L@mD
nadp@xD
nadp@mD
nadh
nadph
g1p
adp
h
h
acmanap
A3
FUMm
nad@mD
dttp
h
B3
h2o
h@eD
C3
ac
ACt2r
G1PTT
D3
ICDHyp
ac@eD
ICDHyrm
atp
pep
ICDHxm
coa
From nitrogen metabolism
TCA Cycle
coa
ACNAM9PL
Butanoate
but@mD
fum@mD
atp@mD
FACOAL40im
dtdpglu
ACS
pi
acnamp
nadph@xD
co2@mD
nadph@mD
ppi
h2o
ppi@mD
amp@mD
amp
TDPGDH
fadh2@mD
co2@xD
ACOAHi
h2o
E3
h2o@mD
coa@mD
h
ppi
ACNMLr
btcoa@mD
SUCD1m
fad@mD
co2@mD
ACNAMPH
nadh@mD
accoa
h2o
ACOAD1fm
fad@mD
akg@xD
pi
coa@mD
akg@mD
dtdp4d6dg
fadh2@mD
gtp@mD
b2coa@mD
Neu5Ac
acnam
h2o@mD
To nucleotide metabolism
acnam@nD
ACNAMtn
TDPDRE
ctp
succ@mD
3HBCDm
coa@mD
SUCOAS1m
ctp@nD
gdp@mD
dtdp4d6dm
CMPSAS
atp@mD
nad@mD
CMPSASn
SUCOASm
pi@mD
3hbcoa-R@mD
h
nadph
coa@mD
ppi@nD
ppi
co2@mD
TDPDRR
pi@mD
CMPACNAtn
cmpacna
AKGDm
nadp
cmpacna@nD
adp@mD
succoa@mD
dtdprmn
nadh@mD
CMP-Neu5Ac
Other Di- and Trisaccharides
tagat-D
lcts@eD
atp
lcts@lD
KHK3
h2o@eD
h2o@lD
SUCRe
LACZly
h
LACZe
tag1p-D
Pentose and glucuronate interconversions
glc-D@eD
glc-D@eD
udpg
atp@nD
FBA5
UDPGlc
pail_hs@nD
pail3p_hs@nD
ppmi12346p
ppmi12346p@nD
PIK3n
nad
glyald
PI3P3Pn
UDPGD
h2o@nD
ump
pi@nD
udpglcur@gD
udpxyl@gD
PI34P4Pn
PI3P4Kn
PIK4n
h2o@nD
adp@nD
h2o
PMI12346PH
PMI12346PHn
MI3456PK
adp
atp@nD
h@nD
atp@nD
UDPGlcA
udpglcur
h
pi@nD
atp@nD
ump@gD
UDPGLCAtg
pi
PI4P4Pn
adp@nD
h
pi@nD
PIK5n
h
adp@nD
h@nD
h
MI13456PK
minohp
PMI1346PH
mi13456p
GUR1PP
h2o@mD
pi
glcur
PMI1346PHn
atp@nD
MI13456Ptn
PI45P5Pn
PI4P5Kn
pi@nD
h2o@nD
adp@nD
h@nD
h2o@nD
h2o@nD
pi@nD
h@nD
atp@nD
atp@nD
C2
pail345p_hs@nD
h@nD
PI5P4Kn
PI345P3Pn
PI45P3Kn
glac@mD
glucarate
nad
h@nD
dag_hs@nD
glac@rD
GLACO
glcur@rD
adp@nD
adp@nD
Orphan Reactions
h@nD
nadph
h@rD
h
MI145P6Kn
PI45PLCn
atp
nadph@rD
MI1345PKn
gal
mi1346p
adp
GLRASE
atp@nD
nadp
PI5P4K
GULNDer
2mcacn
atp@nD
h
h
nadph
h2o
MICITDr
adp@nD
atp@nD
gullac
GALOR
nadp
h@nD
pi
h2o
nadp@rD
PI45P4P
GULLACter
h
mi1345p@nD
MI145PKn
mi145p@nD
h@rD
h2o@rD
gullac@rD
MI1346Ptn
h2o@nD
UROLACer
GLACter
h@nD
adp@nD
pi@nD
h2o
glac
glcr
h2o@nD
mi1346p@nD
atp@nD
h@nD
h@rD
MI1346PKn
mi13456p@nD
E2
atp@nD
h@nD
MI1456PKn
mi1456p@nD
GlcA
adp@nD
D2
pail5p_hs@nD
adp@nD
pail45p_hs@nD
GLCURter
h
h@nD
adp@nD
h@nD
B2
nad@mD
h2o@rD
nadh
ppmi1346p
pail4p_hs@nD
PI4P3Kn
PI34P3Pn
pi@nD
PI34P5Kn
PI345P5Pn
udp
adp@nD
glcr@mD
MINOHPtn
pi@nD
atp@nD
h
h2o
GLACOm
minohp@nD
h2o@nD
pail34p_hs@nD
UDPGNP
nadh@mD
h2o
pi
atp
ppmi1346p@nD
h@nD
h2o@nD
glcur1p
h@mD
atp@nD
h2o
ump
A2
adp
h
h@nD
h@nD adp@nD
UDPG1P
dhap
atp
pi@nD
nadh
h@gD
gal@eD
h2o
h2o@nD
h
UDPGLDCg
gal@lD
glc-D@lD
Inositol phosphate metabolism
mi3456p
h2o
co2@gD
galt
micit
adp
GLNLASEer
guln@rD
pi
h2o
dag_hs
PI345P3P
GULNter
gulonate
IP3
PI45PLC
MI145PK
atp
adp
mi1345p
mi145p
h
atp
h2o
h2o
adp
adp
MI134PK
h
h
PIP2
pail45p_hs
PI45P3K
h
h
nad
adp
atp
h2o
PIP3
pail345p_hs
pail5p_hs
guln
h2o
Itaconate & mesaconate metabolism
h2o
dag_hs@nD
GULN3D
PI4P5K
PI34P5KPI345P5P
h
PI45P5P
h@nD
pail4p_hs@nD
nadh
pi
pail5p_hs@rD
3dhguln
mi14p@nD
h2o
adp
PI5P3Ker
nadp
nad
xylulose
abt
ARABR
h
g6p
atp@rD
pi
h2o
ITCOALm
ITCOAL1m
h2o
adp@mD
MI14PP
MI14P4P
g6p
MI134PP
gdp@mD
pi@mD
pi@mD
MI1PS
atp
arab-L
pi
atp
pi
pi
itaccoa@mD
h2o
pail35p_hs@rD
adp
atp
h
pail3p_hs
pail35p_hs
nadph
h2o
PI4PP
PIK4
h@rD
adp@rD
h@rD
ABTD
dag_hs
From glycolysis
PI4P3Ker
PI3P4K
h2o
gtp@mD
atp@mD
h2o
pail4p_hs@rD
pail34p_hs@rD
adp
adp@rD
h
xylu-L
h
adp
nadph
h
h
adp
h
nadh
coa@mD
mi134p
PI4PLC
h
atp
atp@rD
DGULND
itacon@mD
coa@mD
mi14p
pail4p_hs
h
PI5P3K
PI35P3P
pi
MI14Ptn
PIP
PI4P3K
pail34p_hs
h
pi
PI4PLCn
atp
atp
atp
pi
MI1345PP
MI145PP
h2o@nD
pi
co2
PI3P5K
pail_hs
PIK3
PI
mi1p-D
PIPLC
XYLUR
atp
adp
h2o
h2o
pi
PI3PP
CITMCOAHm
MI134P4P
pi
dag_hs
h2o
MI1P-Dtn
nadp
h2o@mD
mi34p
mi4p-D
mi13p
MI13PP
h
h
citmcoa-L@mD
h2o
pi
xylt
pail_hs@nD
atp
adp
h2o
PIPLCn
PIK5
h
nad
MGACONm
MI4PP
MI1PP
h2o@nD
MI34PP
coa@mD
pi@mD
adp@rD
pi
cmp
h
mescoa@mD
pi
h
mescon@mD
pi@mD
pi
h2o
inost
cdpdag_hs
inositol
mi3p-D
MESCOALm
atp
INOSTO
accoa@mD
h
XYLK
h2o
pyr@mD
adp
B1
h
C1
glcur
xu5p-D
To glucuronate degradation
xylulose 5-phosphate
D1
coa@mD
atp@mD
h2o@mD
MI3PP
o2
MECOALm
adp@mD
accoa@mD
CDIPTr
MECOAS1m
CITMCOALm
pi
nadh
xylu-D
gtp@mD
gdp@mD
h2o@mD
dag_hs@nD
atp@rD
XYLTD_Dr
h2o
mi1p-D@nD
h@nD
pail_hs@rD
PIK3er
pail3p_hs@rD
h@rD
A1
sucr@eD
h2o@eD
adp
h@nD adp@nD
nad
HPYRtp
h@mD
nad@mD
h2o@lD
MALTe
nadh
HPYRR2x
h2o@mD
nadh@mD
2pglyc
HPYRDCm
gcald@mD
h2o
From fatty acid metabolism
malt@lD
malt
h2o
h2o@eD
hydroxypyruvate
h
pi
ala-L@xD
pyr@xD
TPI
acgam
co2
h2o
h
G3PD2m
CHTNASE
acgam@eD
nad
h
nadh
glyclt
g3p
glc-D@eD
From serine metabolism
dhap
nh4@xD
fad@mD
fadh2@mD
acald
MLTG1ly
MLTG1
MLTG1e
TREH
h2o@eD
h2o@lD
h2o
h2o2@xD
GLYOp
h2o2@xD
DRBK
2dr5p
chtn
h
h2o@eD
GLYCLTDy
h2o@xD
o2@xD
FBA
Chitin
nadp@mD
GLXtp
GLXO2p
r1p
prpp
Maltotriose
Trehalose
nadph
h2o2@xD
RBK
amp
h
GLYCLTDym
h
h@xD
GLYtp
rib-D
s7p
adp
nadph@mD
oxalate
RPI
r5p
atp
KHK2
glx
oxa
rbl-D
RBK_D
TALA
h@mD
h2o
h
ru5p-D
xu5p-D
RPE
e4p
GLXtm
nad
PFK
adp
h
glc-D@eD
atp
nadh
nadph
TKT2
xylu-D
AGTim
gly@mD
ru5p-D@rD
co2
MALTe
glyoxalate
glx@mD
nadph@rD
nadp
glygn2
ala-L@mD
E1
fru@eD
fucose
fuc-L
atp
FK
adp
h
fuc1p-L
Fructose, mannose, and fucose metabolism
mannose
gtp
Galactose metabolism
Ascorbate Metabolism
man
gal
atp
atp
h
h2o
F1PGT
h2o
h
GDPFuc
GMAND
gdpddman
fructose
h
MAN1PT2
gdpmann
PMANM
man1p
f6p
MAN6PI
man6p
HEX7
DASCBH
ASCBOX
DOGULND1
SBTR
sbt-D
h
h
gal1p
udpg
UDPGlc
co2
atp
Ascorbate
DHA
lyxnt
glc-D
SBTD_D2
ascb-L
dhdascb
h
h
fru
pi
atp
h2o2
23doguln
nadph
nadp
adp
o2s
nad
atp
h
gdp
GDPMan
GFUCS
gdpfuc
nadh
adp
h
pi
h2o
DOGULND2
nadph
nadp
dopa
GALK
h
xylnt
ppi
DOPABMO
nrpphr
h2o
co2
HEX4
adp
o2
h2o2
h2o
GTHDH
h2o
pep
PFK26
ACNAM9PL2
h2o
utp
h
eryth
DASCBR
h
GALT
nadp
UGLT
utp
nadph
f26bp
GALU
UDPGP
UDPG4E
h
h2o
h
h
pi
ppi
h2o
gthox
DOGULNO1
DOGULNO2
adp
adp
h
gthrd
oxa
KHK
FBP26
h
ppi
f1p
oxa
kdnp
h
ump
thrnt
FBA2
g1p
h2o
udpgal
dhap
UDPGal
KDNH
ump@gD
glyald
pi
UDPGALtg
atp
kdn
TRIOK
KDN
ump
adp
h
udpgal@gD
g3p
glc-D@gD
g3p
UGALGTg
h@gD
udp@gD
A5
B5
Glycolysis
C5
Glycogen & Starch
D5
E5
lactose
lcts@gD
glc-D
GLCter
Glycogen biosynthesis
Glycogen degradation
Starch degrdation
atp
glc-D@rD
cbp@rD
glygn2@eD
strch1@eD
glygn2
Tyr-ggn
h@rD
pi@rD
h2o@eD
h2o@eD
udpg
pi
HEX1
AMY2e
AMY1e
GGNG
GLPASE1
glc-D@eD
CBPPer
G6PPer
h
g1p
udp
glygn4@eD
glc-D@eD
adp
dxtrn
co2@rD
nad@rD
nh4@rD
nadh@rD
h
nadph
h2o
O16G1e
h2o@eD
h@rD
h2o@rD
ggn
h2o@eD
strch2@eD
nadp
h
g6p@rD
G6PDH1rer
nad@rD
G6PDH2r
udp
PGL
PGI
G6PDH2rer
g1p
Pentose Phosphate Pathway
GLBRAN
GLPASE2
nadph@rD
f6p
nadp@rD
h@rD
pyr@mD
glycine
co2@rD
from glycogen breakdown, to nucleotide
6pgc
Tyr-ggn
From glucuronate degrdation
GNDer
h
h2o
malt@eD
From hydroxyproline degrdation
PGMT
glygn1
glygn3
GAMYe
Tyr-ggn@eD
nadp@rD
h@rD
h2o
h2o@eD
glc-D@eD
PGLer
nadh@rD
6pgl
glc-D
Glyoxylate metabolism
6pgc@rD
G6Pter
g6p
GLGNS1
h
glygn5@eD
h@rD
6pgl@rD
GLDBRAN
glc-D@eD
O16G2e
h2o@rD
G6PDH1er
udpg
gly
GLYtm
pi
GND
e4p
h2o@eD
glc-D
f6p
atp
g3p
f6p
FBP
atp
TKT1
GLXO1
h
adp
h
h2o
adp
atp
oxa@xD
xu1p-D
Di- and polysaccharide degradation
h
fdp
PPM
PRPPS
To nucleotide metabolism
h2o@xD
DRPA
g3p
tre@eD
malttr@eD
tre
malttr@lD
malttr
chtn@eD
h2o@eD
h2o
TREHe
drib
atp
CHTNASEe
nadp
glx@xD
AGTix
gly@xD
dhap
adp
h2o
FBA4
glyclt@mD
o2@xD
glycolate
o2@xD
glc-D@lD
glc-D
glc-D@eD
glc-D
GLYCTO1p
GLYCLTtp
glyclt@xD
glyc3p
malt@eD
GCALDD
hpyr
HPYRDC
gcald
h
nadph
PGLYCP
Ketogenesis
GCALDDm
glyclt@mD
pi
SPTix
nad
hpyr@mD
HPYRRy
co2@mD
nad@mD
h@mD
h@mD
nadp
co2@mD
h@mD
nadh@mD
h@mD
h@eD
h
h
GAPD
ser-L@xD
hpyr@xD
glyc-R
acetone
BDHm
bhb@mD
MALT
ADCim
acac@mD
glyc-S
ACETONEt2m
acetone@mD
acetone@eD
ACETONEt2
atp
h
MALTly
h
nadh
nadph
glc-D@eD
glc-D
GLYCK2
13dpg
glc-D@lD
o2
DPGM
Methylglyoxal metabolism
h
adp
ACTNMO
A4
B4
adp
h2o
C4
D4
h2o
23dpg
nadp
pi
nadp
nadph
ALR3
acetol
MGSA
dhap
ACYP
PGK
h
12ppd-S
h2o
h
L-1,2-propanediol
nadph
To glycolysis
pi
DPGase
nadp
pi
h
E4
2pg
atp
h
From glycolysis
3pg
nad
o2
Aminosugars Metabolism
MGSA2
g3p
pi
ACTLMO
nadp
ALR2
o2
h2o2
h2o
aact
gln-L
h2o@mD
mthgxl
glu-L
h
atp
adp
h
h
h
LALDO2x
nad
LALDD
LALDO2
ac
lac-D@mD
pep
LGTHL
gthrd
nadh
h
nadph
h2o
LDH_L
lac-L
nadh
acac
atp@mD
acald@eD
nad
UAGALDP
acgal
acgal1p
h2o
GalNAc
Ethanol
etoh@eD
ac@mD
ALDD2xm
ACSm
ppi@mD
oaa
h2o@mD
coa
h2o
cit@mD
h2o
h2o
ALDD2x
ALDD2y
CAT2p
etoh@xD
h2o2@xD
PPCOAOm
h
To nucleotide metabolism
fadh2@mD
2mcit
nadh@mD
acald@xD
icit@xD
h
nad@mD
icit@mD
h
h2o@xD
prpncoa@mD
MDHm
ACONTm
ACALDtx
Nucleotide Sugar Metabolism
h@mD
To lipid metabolism
nad
nadp
ManNAc
AMANK
MCITS
fad@mD
nad@mD
h@mD
nadp
o2
h2o
nadp@mD
oaa@mD
CSm
ETOHMO
nadph
udp
pi
ppcoa@mD
coa@mD
coa@mD
h
adp
amp@mD
atp@mD
nadh@mD
nad@mD
h@mD
atp
ME1m
ppi@mD
h2o@mD
ACCOAL
ppcoa
itp
h
ACS2
ppi
amp@mD
accoa@mD
h
acmana
ME2m
To lipid metabolism
nadph
coa
amp
co2@mD
h
ALCD2yf
atp
coa
ACCOALm
co2@mD
ACALDtm
atp
nadh@mD
acald@mD
acald
nadp
ppa@mD
nad@mD
ACALDt
ETOHt
ACGALK2
idp
UAG2EMAi
acgam
ppa
coa@mD
atp@mD
co2@mD
nadh@mD
udpacgal
nad
gtp@mD
pi@mD
h@mD
PCm
coa@mD
h
nadh
nad
etoh
UAG4E
adp@mD
hco3@mD
pyr@mD
PDHm
nadh
ALCD2if
h
h
h@mD
nadh@mD
LDH_Lm
h
ACGALK
UDP-GlcNAc
LDH_D
lac-D
atp
utp
h@mD
nad@mD
lac-L@mD
nadh@mD
nadph@mD
adp
ppi
nadh
PYRt2m
oaa@mD
h
UDP-GalNAc
accoa@mD
2hb
PEPCKm
h@mD
uacgam
fum
atp
2obut
h
h
L-LACtcm
LCADim
nadh
12ppd-R
ppi
coa
2HBO
nadh@mD
nad
nad@mD
gthrd
utp
UAGDP
AACOAT
gdp@mD
FUM
mal-L
LCADi_D
nadp
nad
MMSAD3m
h2o
ME2
pyr
h2o@mD
h
acgam1p
amp
nad
co2@mD
nad
adp
pyr
nadp
h
co2@mD
GLYOX
ACGAM2E
nadph co2
L-LACDcm
L-lactate
h
GlcNAc
nad
atp
lald-L@mD
ALCD21_DPPDOy
aacoa
ppi
nad@mD
h2o
ACGAMPM
atp
pep@mD
nadh
nadh
nadh
h
nad
h
h
nad
3hpp
coa@mD
MDH
focytC@mD
lgt-S
h2o
acgam6p
h
3HPPD
msa@mD
msa
h
PPDOx
gtp
co2
ficytC@mD
LALDO
h
gdp
PYK
lald-D
ACGAMK
h
h
h
nadh
Propanoate Metabolism
nadh
adp
LCADi
nad
coa
oaa
nadp
nadp
ACGAM6PSi AGDC
h
adp
pi
accoa
PEPCK
nadh
ALCD22_D
nad
ACITL
nadh@mD
gthrd
nadph
GlcN
gam
nadph
ac
h2o
gthrd@mD
nadph
CITL
h@mD
h@mD
h2o
HEX10
accoa
lald-L
ALCD22_L
h
nadh
gam6p
ENO
GLYOXm
LCADi_Dm
nad
nadh
methylglyoxal
h2o
atp
nadh
h
G6PDA
GF6PTA
akg
ICDHy
coa
2pg
nad@mD
h
AACTOOR
icit
ACONT
h2o@mD
h
nadp
nh4
cit
lald-D@mD lgt-S@mD
nadph
nh4
h2o
From glycine
co2
PGM
ALCD21_L
f6p
mal-L@mD
nadp@xD
nadp@mD
nadh
nadph
g1p
adp
h
h
acmanap
A3
FUMm
nad@mD
dttp
h
B3
h2o
h@eD
C3
ac
ACt2r
G1PTT
D3
ICDHyp
ac@eD
ICDHyrm
atp
pep
ICDHxm
coa
From nitrogen metabolism
TCA Cycle
coa
ACNAM9PL
Butanoate
but@mD
fum@mD
atp@mD
FACOAL40im
dtdpglu
ACS
pi
acnamp
nadph@xD
co2@mD
nadph@mD
ppi
h2o
ppi@mD
amp@mD
amp
TDPGDH
fadh2@mD
co2@xD
ACOAHi
h2o
E3
h2o@mD
coa@mD
h
ppi
ACNMLr
btcoa@mD
SUCD1m
fad@mD
co2@mD
ACNAMPH
nadh@mD
accoa
h2o
ACOAD1fm
fad@mD
akg@xD
pi
coa@mD
akg@mD
dtdp4d6dg
fadh2@mD
gtp@mD
b2coa@mD
Neu5Ac
acnam
h2o@mD
To nucleotide metabolism
acnam@nD
ACNAMtn
TDPDRE
ctp
succ@mD
3HBCDm
coa@mD
SUCOAS1m
ctp@nD
gdp@mD
dtdp4d6dm
CMPSAS
atp@mD
nad@mD
CMPSASn
SUCOASm
pi@mD
3hbcoa-R@mD
h
nadph
coa@mD
ppi@nD
ppi
co2@mD
TDPDRR
pi@mD
CMPACNAtn
cmpacna
AKGDm
nadp
cmpacna@nD
adp@mD
succoa@mD
dtdprmn
nadh@mD
CMP-Neu5Ac
Other Di- and Trisaccharides
tagat-D
lcts@eD
atp
lcts@lD
KHK3
h2o@eD
h2o@lD
SUCRe
LACZly
h
LACZe
tag1p-D
Pentose and glucuronate interconversions
glc-D@eD
glc-D@eD
udpg
atp@nD
FBA5
UDPGlc
pail_hs@nD
pail3p_hs@nD
ppmi12346p
ppmi12346p@nD
PIK3n
nad
glyald
PI3P3Pn
UDPGD
h2o@nD
ump
pi@nD
udpglcur@gD
udpxyl@gD
PI34P4Pn
PI3P4Kn
PIK4n
h2o@nD
adp@nD
h2o
PMI12346PH
PMI12346PHn
MI3456PK
adp
atp@nD
h@nD
atp@nD
UDPGlcA
udpglcur
h
pi@nD
atp@nD
ump@gD
UDPGLCAtg
pi
PI4P4Pn
adp@nD
h
pi@nD
PIK5n
h
adp@nD
h@nD
h
MI13456PK
minohp
PMI1346PH
mi13456p
GUR1PP
h2o@mD
pi
glcur
PMI1346PHn
atp@nD
MI13456Ptn
PI45P5Pn
PI4P5Kn
pi@nD
h2o@nD
adp@nD
h@nD
h2o@nD
h2o@nD
pi@nD
h@nD
atp@nD
atp@nD
C2
pail345p_hs@nD
h@nD
PI5P4Kn
PI345P3Pn
PI45P3Kn
glac@mD
glucarate
nad
h@nD
dag_hs@nD
glac@rD
GLACO
glcur@rD
adp@nD
adp@nD
Orphan Reactions
h@nD
nadph
h@rD
h
MI145P6Kn
PI45PLCn
atp
nadph@rD
MI1345PKn
gal
mi1346p
adp
GLRASE
atp@nD
nadp
PI5P4K
GULNDer
2mcacn
atp@nD
h
h
nadph
h2o
MICITDr
adp@nD
atp@nD
gullac
GALOR
nadp
h@nD
pi
h2o
nadp@rD
PI45P4P
GULLACter
h
mi1345p@nD
MI145PKn
mi145p@nD
h@rD
h2o@rD
gullac@rD
MI1346Ptn
h2o@nD
UROLACer
GLACter
h@nD
adp@nD
pi@nD
h2o
glac
glcr
h2o@nD
mi1346p@nD
atp@nD
h@nD
h@rD
MI1346PKn
mi13456p@nD
E2
atp@nD
h@nD
MI1456PKn
mi1456p@nD
GlcA
adp@nD
D2
pail5p_hs@nD
adp@nD
pail45p_hs@nD
GLCURter
h
h@nD
adp@nD
h@nD
B2
nad@mD
h2o@rD
nadh
ppmi1346p
pail4p_hs@nD
PI4P3Kn
PI34P3Pn
pi@nD
PI34P5Kn
PI345P5Pn
udp
adp@nD
glcr@mD
MINOHPtn
pi@nD
atp@nD
h
h2o
GLACOm
minohp@nD
h2o@nD
pail34p_hs@nD
UDPGNP
nadh@mD
h2o
pi
atp
ppmi1346p@nD
h@nD
h2o@nD
glcur1p
h@mD
atp@nD
h2o
ump
A2
adp
h
h@nD
h@nD adp@nD
UDPG1P
dhap
atp
pi@nD
nadh
h@gD
gal@eD
h2o
h2o@nD
h
UDPGLDCg
gal@lD
glc-D@lD
Inositol phosphate metabolism
mi3456p
h2o
co2@gD
galt
micit
adp
GLNLASEer
guln@rD
pi
h2o
dag_hs
PI345P3P
GULNter
gulonate
IP3
PI45PLC
MI145PK
atp
adp
mi1345p
mi145p
h
atp
h2o
h2o
adp
adp
MI134PK
h
h
PIP2
pail45p_hs
PI45P3K
h
h
nad
adp
atp
h2o
PIP3
pail345p_hs
pail5p_hs
guln
h2o
Itaconate & mesaconate metabolism
h2o
dag_hs@nD
GULN3D
PI4P5K
PI34P5KPI345P5P
h
PI45P5P
h@nD
pail4p_hs@nD
nadh
pi
pail5p_hs@rD
3dhguln
mi14p@nD
h2o
adp
PI5P3Ker
nadp
nad
xylulose
abt
ARABR
h
g6p
atp@rD
pi
h2o
ITCOALm
ITCOAL1m
h2o
adp@mD
MI14PP
MI14P4P
g6p
MI134PP
gdp@mD
pi@mD
pi@mD
MI1PS
atp
arab-L
pi
atp
pi
pi
itaccoa@mD
h2o
pail35p_hs@rD
adp
atp
h
pail3p_hs
pail35p_hs
nadph
h2o
PI4PP
PIK4
h@rD
adp@rD
h@rD
ABTD
dag_hs
From glycolysis
PI4P3Ker
PI3P4K
h2o
gtp@mD
atp@mD
h2o
pail4p_hs@rD
pail34p_hs@rD
adp
adp@rD
h
xylu-L
h
adp
nadph
h
h
adp
h
nadh
coa@mD
mi134p
PI4PLC
h
atp
atp@rD
DGULND
itacon@mD
coa@mD
mi14p
pail4p_hs
h
PI5P3K
PI35P3P
pi
MI14Ptn
PIP
PI4P3K
pail34p_hs
h
pi
PI4PLCn
atp
atp
atp
pi
MI1345PP
MI145PP
h2o@nD
pi
co2
PI3P5K
pail_hs
PIK3
PI
mi1p-D
PIPLC
XYLUR
atp
adp
h2o
h2o
pi
PI3PP
CITMCOAHm
MI134P4P
pi
dag_hs
h2o
MI1P-Dtn
nadp
h2o@mD
mi34p
mi4p-D
mi13p
MI13PP
h
h
citmcoa-L@mD
h2o
pi
xylt
pail_hs@nD
atp
adp
h2o
PIPLCn
PIK5
h
nad
MGACONm
MI4PP
MI1PP
h2o@nD
MI34PP
coa@mD
pi@mD
adp@rD
pi
cmp
h
mescoa@mD
pi
h
mescon@mD
pi@mD
pi
h2o
inost
cdpdag_hs
inositol
mi3p-D
MESCOALm
atp
INOSTO
accoa@mD
h
XYLK
h2o
pyr@mD
adp
B1
h
C1
glcur
xu5p-D
To glucuronate degradation
xylulose 5-phosphate
D1
coa@mD
atp@mD
h2o@mD
MI3PP
o2
MECOALm
adp@mD
accoa@mD
CDIPTr
MECOAS1m
CITMCOALm
pi
nadh
xylu-D
gtp@mD
gdp@mD
h2o@mD
dag_hs@nD
atp@rD
XYLTD_Dr
h2o
mi1p-D@nD
h@nD
pail_hs@rD
PIK3er
pail3p_hs@rD
h@rD
A1
sucr@eD
h2o@eD
adp
h@nD adp@nD
nad
HPYRtp
h@mD
nad@mD
h2o@lD
MALTe
nadh
HPYRR2x
h2o@mD
nadh@mD
2pglyc
HPYRDCm
gcald@mD
h2o
From fatty acid metabolism
malt@lD
malt
h2o
h2o@eD
hydroxypyruvate
h
pi
ala-L@xD
pyr@xD
TPI
acgam
co2
h2o
h
G3PD2m
CHTNASE
acgam@eD
nad
h
nadh
glyclt
g3p
glc-D@eD
From serine metabolism
dhap
nh4@xD
fad@mD
fadh2@mD
acald
MLTG1ly
MLTG1
MLTG1e
TREH
h2o@eD
h2o@lD
h2o
h2o2@xD
GLYOp
h2o2@xD
DRBK
2dr5p
chtn
h
h2o@eD
GLYCLTDy
h2o@xD
o2@xD
FBA
Chitin
nadp@mD
GLXtp
GLXO2p
r1p
prpp
Maltotriose
Trehalose
nadph
h2o2@xD
RBK
amp
h
GLYCLTDym
h
h@xD
GLYtp
rib-D
s7p
adp
nadph@mD
oxalate
RPI
r5p
atp
KHK2
glx
oxa
rbl-D
RBK_D
TALA
h@mD
h2o
h
ru5p-D
xu5p-D
RPE
e4p
GLXtm
nad
PFK
adp
h
glc-D@eD
atp
nadh
nadph
TKT2
xylu-D
AGTim
gly@mD
ru5p-D@rD
co2
MALTe
glyoxalate
glx@mD
nadph@rD
nadp
glygn2
ala-L@mD
E1
fru@eD