CURRICULUM VITAE
Name:
Anselmo de Jesús Otero-González.
Birth date:
October 15, 1953
Place of birth:
Havana City
Nationality:
Cuban
Sex:
Male
Marital status:
Divorced, two children.
E-mail:
[email protected]
Titles:
[email protected]
Dr. Biological Sciences (PhD), 1987
Dr. Sciences (ScD), 2008
Education: 09/1969-06/1973:
09/1973-06/1978:
Graduated from the high school, Havana City.
B.Sc. in Microbiology (1st Class Honours), Faculty of Biology,
University of Havana, Cuba. (Tutor: Dr. Ing. Mario J. Villaverde,
Ph.D.)
Graduated studies:
09/1981-10/1987:
PhD: National Center for Scientific Research, Havana, Cuba.
(Advisor: Dr. Jorge Sarracent Perez, PhD, current address:
Institute of Tropical Medicine “Pedro Kouri”, Havana Cuba)
03/1981-06/1981:
Protein Separation School, Biomedical Center (BMC), University of
Uppsala, Sweden. (Professor: Stellan Hjerten).
04/1982-05/1984:
ELISA course, National Center for Scientific Research, Havana,
Cuba. (Professors: Dr. Alister Voller and Dennis Bidwell from
the Nuffield Institute of Comparative Medicine, Institute of
Zoology, London, England).
03/1983-06/1983:
Hybridoma Technology, Pennsylvania University School of
Medicine, Philadelphia, USA. (Advisor: Dr. Roger H. Kennett,
Head of Dept of Genetics)
01/1991-02/1991:
Cell banking, European Collection of Animal Cell Cultures, Porton
Down, Salisbury, UK. (Advisor: Dr. Allan Doyle).
12/2001:
Immunology of Infectious diseases, Institute of Tropical Medicine
“Pedro Kouri”, Havana Cuba, (Professor: J. A Louis, Head of
WHO program: Research and Training on Immunology,
Vaccinology and Biotechnology of Infectious Diseases
Research Experience:
10/78-07/1979:
Electron microscopy of Mycobacterium leprae at National Center
for Scientific Research, Havana, Cuba. (Advisor: Dr. Juan. Kouri,
current address: Dept. Electron Microscopy, National Autonomic
University of Mexico (UNAM), Mexico City).
09/1979-12/1980:
Mycobacterium leprae infected mouse macrophage plasma
membrane isolation and characterization at National Institute of
Oncology and Radiobiology, Havana. (Advisor: Dr. Agustin Lage
Davila, Ph.D., current address: Director of The Center of
Molecular Immunology, Havana, Cuba).
09/1981-04/1984:
ELISA by Ultra micro Analytical System for diagnosis of infectious
agents (Advisor: Dr. Jose L. Fernandez Yero, current address:
Vice Director of BioCubaFarma and former Director of the Center
of Immunoassays, Havana, Cuba).
05/1984-11/1989:
Generation of monoclonal antibodies against Hepatitis B surface
antigen at National Center for Scientific Research, Havana, Cuba
(Advisor: Professor Dr. Antonio Gonzalez Griego, Superior
Institute of Medical Sciences, Havana, Cuba)
12/1989-07/1998:
Immunodiagnostics of infectious diseases with monoclonal
antibodies, Institute of Tropical Medicine “Pedro Kouri”, Havana
Cuba, (Advisor: Dr. Professor Gustavo Kouri, Ph.D., General
Director)
12/1991-06/1992:
Research Project (AIDS-HIV vaccine), Swedish Center of Disease
Control, Stockholm, Sweden (Advisor: Professor Britta Wahren,
Head Dept of Virology).
09/1998-03/2005:
Immunochemistry of cytolysisns. Center for Protein Studies (CEP),
Faculty of Biology, Havana University (Advisor: Dr. Professor
Maria de los Angeles Chavez Planes, Director).
07/2002-12/2004:
Immunodiagnostics of plant infectious diseases and isolation and
characterization of antimicrobial peptides. Center for
Biotechnological Research of Ecuador (CIBE), High Polytechnic
School of the Coast (ESPOL), Guayaquil, Ecuador (Partner: Dr.
Rodolfo H. Maribona Hernandez, Ph.D., Director).
02/2006-03/2006
Immunodiagnosis of S. Pneumoniae infection in urine samples.
(Partner: Dr. Juan Ramón de los Toyos, University of Oviedo,
Spain)
06/2007-10/2012
Antimicrobial peptides. (Partner: Dr. Octavio Luiz Franco,
Universidad Católica de Brasilia, Brasil, DF and Dr. Michael
Starnbach, Harvard Medical School, Boston Ma,
Fellowships:
03/1981:
Swedish Commission for Technical Cooperation (Biomedical
Center, Uppsala Sweden).
09/1884:
United Nations University, Tokyo, Japan (Sponsor: Dr. Nevin S.
Scrimshaw). No visa for entrance in USA
12/1990:
Swedish Institute, Stockholm, Sweden for the project at the Swedish
CDC.
04/2001:
Center David Rockefeller of Latin-American Studies, Project to be
developed about antigen presentation and immuno-addressing at
HSPH, Harvard University (Sponsor: Dr. John David, Advisor:
Harvard School of Public Health, Harvard University, Boston,
USA, 6/2005-09/2005)
Positions:
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Head of Cell Culture Dept, the National Center for Scientific Research, Havana, Cuba
(1984-1989).
Head of Hybridoma Lab, Institute of Tropical Medicine “Pedro Kouri” Havana, Cuba.
(1990-1998)
Senior Professor and Researcher Faculty of Biology Havana University, Havana,
Cuba. (from 1998).
Senior professor Institute of Tropical Medicine “Pedro Kouri” Havana, Cuba. (from
1990)
Member (1995-2003), Secretary (2000-2003) and President (from 2003) of the
National Board for PhD examination in Cellular and Molecular Biology
Head of Immunology Laboratory, Dept Biochemistry, Faculty of Biology, Havana
University, Havana, Cuba. (from 1998)
Head of Immunoanalytics and Antimicrobial Peptide Laboratory, Center for Protein
Studies, Faculty of Biology, Havana University, Havana, Cuba. (since 2006)
Areas of interest:
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Host defense peptides.
Hybridoma Technology and Monoclonal Antibodies.
Immunodiagnostics of Infectious Diseases
Animal Cell Culture and Collection.
Protein and nucleotide adjuvants and immuno-stimulants.
Antigen presentation and immuno-addressing
ELISA and related techniques.
Protein purification and characterization.
Current projects:
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Molecular characterization of synthetic antimicrobial peptides from marine
invertebrates. Harvard Medical School, (2011.2012), Boston, USA.
Estudo do mecanismo de ação do peptídeo sintético CM-5 anti-fungo derivados de o
molusco costeiro Cenchtritis muricatus por seu conjugação com nanopartículas
magnéticas MnFe2O4 em sua interação com alvos moleculares em patógenos fúngicos
clinicamente importantes, veterinários e agrícolas. CAPES, Brazil
Expressão heteróloga e nanoformulação do peptídeo antimicrobiano derivado do
molusco marino Centrichis muricatus, CNPq, Brazil
Isolation and characterization of natural antibacterial peptides with LPS affinity from
marine invertebrates. IFS 2013-2016. Sweden.
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Scientific Articles: 85
Abstracts: 149
Selected Articles:
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Otero, A.J., Sarracent, J., Fernandez Yero, J.L., and Rodriguez, I. (1984) A 10 micro
liter ultra-micro ELISA for detection of monoclonal antibodies against human
alpha-fetoprotein. Hybridoma: vol 3, 391-396.
Otero, A.J. and Kennett, R.H. (1984) ELISA for immunoglobulin subclass
determination. In “Monoclonal Antibodies and Functional cell lines. Progress and
Applications”. Kennett, R.H. Bechtold, K.B. and McKearn, T.J. (eds.) Plenum
Press. New York. pp. 374-376.
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Otero, A., Rodriguez, I. and Falero, G. (1991) 2,3,5-Tryphenyl Tetrazolium Chloride
(TTC) reduction as exponential phase marker for mammalian cells in culture and
for myeloma hybridization experiments. Cytotechnology. 6: 137.
Falero, G., Sarracent, J. Otero, A. Rodriguez, I and Rodriguez, B.R. (1992)
Generation of bispecific triomas which recognized the “ad” subtype of Hepatitis B
surface antigen. Hybridoma vol 11, No. 6.pp 815-823.
Marrero, M., Valdes, O., Alvarez, M., Penate, G., Morales, E., Roges, G. and Otero,
A. (1994) Non-Radioactive Hybridization for the detection of human Papiloma
virus in cervix scrapes. Diagnostic Microbiology & Infectious Diseases. vol 18:
95-100.
Obregon, A.M., Otero, A, Laferte, J., Y Lopez, C. (1994) ELISA for the detection of
human Leptospirosis. Mem does Instituto Oswaldo Cruz 89: 3, 365.
Broliden, K, Hinkula, J., Bratt, G., Persson, C., Otero, A.J., Ekstrom, A., Sandstrom,
E., Broliden, P.A. and Wahren, B. (1996) Analyses of functional antibody
esponses in HIV-1 infected individuals after vaccination with r-gp 160. Clinical
and Diagnostic Virology vol 6, 115-126.
Vilaseca JC, Pupo M, Bernal M, Matamoros L, Gordillo S, Rodriguez H, Caballero Y
and Otero A. (1997) Quantitative ELISA for mouse monoclonal antibody
determination in culture supernatants and in human serum. Hybridoma vol 16 (6):
557-562.
Pupo M, Rodriguez H, Vazquez S, Vilaseca JC, Pelegrino J, Alvarez M, Caballero Y,
Otero A and Guzman M. (1997) Monoclonal antibodies against Dengue 2 Cuban
strain A15 which recognize structural viral proteins.. Hybridoma Vol 16(4): 353359.
Valdivia A, Savon C, Chacon D, Sarmientos L, Morier L, Otero A, Soto Y, Oropesa
S, Goyenechea A. (1997) Analysis of Respiratory Syncytial virus in Clinical
Samples by Reverse Transcriptase Polymerase Chain Reaction Restriction
Mapping. Mem. Inst Oswaldo Cruz.. Vol. 92. No. 3: 389-393.
Valdivia A, Chacon D, Savon C, Sarmientos L, Valdes O, Otero A, D. Rosario,
Goyenechea A. (1997) Molecular Characterization of an Outbreak of Respiratory
Syncytial Virus (subgroup A) in Havana Cuba by Monoclonal Antibodies and
Restriction Mapping gene (N). Clinical and Diagnostic Laboratory Immunology.
vol 4. No. 5.
Miguez, J., Laferte, J., Tejero, Y, Gonzalez, G., Otero, A.J., Rivero, J., Duarte, C.
(1998) Evaluation of the serologic response against two consensus V3 loop
peptides from human immunodeficiency virus-1 in Cuban patients. International
Journal of Infectious Diseases. 2(4): 221-225.
Valdivia A, Gonzalez G, Chacon D, Savon C, Otero A.J, Valdes O, Cancio R,
Oropesa S, Melero J.A, Garcia-Barreno A, Goyenechea A. (1999) Antigenic and
Genetic Characterization of Twenty-six Strains of Human Respiratory Syncytial
Virus (Subgroup A) Isolated During Three Consecutive Outbreaks in Havana
City, Cuba. Mem. Inst. Oswaldo Cruz, July 1999, vol.94, no.4, p.469-475.
Pupo-Antunez M, Rodriguez R, Alvarez M, Amin N, Rodriguez H, Otero A, Guzman
G. (2001) Development of a monoclonal antibody specific to a recombinant
envelope protein from dengue virus type 4 expressed in Pichia pastoris.
Hybridoma. (1):35-41.
Gutierrez OA, Salas E, Hernandez Y, Lissi EA, Castrillo G, Reyes O, Garay H,
Aguilar A, Garcia B, Otero A, Chavez MA and Duarte CA (2002) An
Immunoenzymatic Solid-Phase Assay for Quantitative Determination of HIV-1
Protease Activity. Anal. Biochem. 307(1): 18-24.
Pico, M.C., Basulto, A., Del Monte, A., Hidalgo, A., Lanio, M.E., Alvarez, C.M.,
Felico, E., and Otero, A. J. (2004). Cross-Reactivity And Inhibition Of
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Haemolysis By Polyclonal Antibodies Raised Against St II, A Cytolysin From
The Sea Anemone Stichodactyla helianthus. Toxicon, vol 43, 167-171
Salas, E., Ramirez, A., Otero-Bilbao, A., Vazquez, R., Reyes, O., Mendiola, J., Duarte,
C., Otero, A.J., Gutierez, O. And Chavez, M.A. (2004) A heterogeneous
enzymatic immunoassay for the quantification of Plasmepsin II activity and the
evaluation of its inhibitors. Journal of Pharmaceutical and Biomedical Analysis
34, 833-840 (2004).
Rodríguez, H., Pupo, M., Ilnait, M.T., Otero, A.J. y Martínez, G. (2005) Anticuerpos
monoclonales que reconocen al polisacárido capsular de Cryptococcus
neoformans. Revista Cubana de Medicina Tropical 57(2): 162-164.
Basulto, A., Perez, V.M., Noa, Y,., Varela, C., Otero, A.J and Pico, M.C. (2006)
Immunohistochemical targeting of sea anemone cytolysins on tentacles,
mesenteric filaments, and isolated nematocysts of Stichodactyla helianthus.
Journal of Experimental Zoology, Jan 23; 305A(3):253-258, 2006.
Calderón L, E Facenda, L Machado, K Uyema, D Rodríguez, E Gomez, Y Martínez, B
González, V Bourg, C Alvarez, A Otero, M Russo, A Labrada, ME Lanio (2006)
Modulation of the Specific Allergic Response by Mite Allergens Encapsulated
into Liposomes. Vaccine. Apr 12;24 Suppl 2:S2-38-9.
Gato R., Martínez, G., Otero A.J., Sarracent, J., Rodríguez, H.,
Valdés, I.,
Fernández, C.M., Perurena, M and Illnait, M.T. Determinación de la capacidad del
AcM 4B3 anti glucuronoxilomanano para reconocer células intactas de
Cryptococcus neoformans. Rev Cubana Med Trop vol. 58 no. 2 Ciudad de la
Habana May-Aug.
Ariel Basulto Perdomo, Isis Casadelvalle Pérez, Anselmo Otero González and María
C. Pico Beltrán. Sticholysin II, a cytolysin isolated from the Caribbean Sea
anemone Stichodactyla helianthus, interacts with serum lipoproteins, Freund
adjuvant and specific antibodies to this protein. Rev. Invest. Mar. 27(1): 41-48,
2006.
María Cristina Pico, Isabel G. Giraldino, Anselmo J. Otero, Joaquín Díaz-Brito.
Myoglobin: Its role in homeostasis of nitric oxide, depuration of oxygen reactive
species and apoptosis induction. Review article. Revista Biología 2006 (en
prensa).
Otero AJ, Sarracent J, Hernández H, Sánchez M, Muirragui D, Villamar M, Moreta
D, Jiménez, MI, Pérez L and Maribona RH (2007) Monoclonal Antibody-based
TAS-ELISA for Quantitative Detection of Mycosphaerella fijiensis Antigens.
Journal of Phytopathology, 155 (11-12), 713-719.
Otero-González AJ, Simas Magalhães B, Garcia-Villarino M, López-Abarrategui C,
Amaro Sousa D, Campos Dias S, Luiz Franco O. (2010) Antimicrobial peptides
from marine invertebrates as a new frontier for microbial infection control.
FASEB J, 24, 1320-1334.
Otero AJ (2010) Los anticuerpos y su rol como herramientas analíticas en los ensayos
inmunoensayos enzimáticos. Rev Cub Med Trop. 62(2): 85-92.
Otero AJ. (2010) Los inmunoensayos enzimáticos para detectar agentes infecciosos o
sus productos: Algunos diseños y aplicaciones. Rev Cub Med Trop. 62(3): 167179.
Alba-Menéndez,A., López-Abarrategui, C., Vázquez-Perera,AJ., Otero- González,
AJ (2011) Optimización de la solución de extracción de moléculas antibacterianas
de Cenchritis muricatus (Gastropoda: Littorinidae). Rev Cub Med Trop 63(2):171176.
Figueroa-Espí, V, A. Alvarez-Paneque, M. Torrens, A.J. Otero-González, E. Reguera
(2011) Conjugation of manganese ferrite nanoparticles to an anti Sticholysin
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monoclonal antibody and conjugate applications. Colloids and Surfaces A:
Physicochemical and Engineering Aspects, vol 387(1-3): 118-124.
Silva, ON., Mulder, KCL., Barbosa, AEAD, Otero-Gonzalez, AJ, LopezAbarrategui, C., Rezende, TMB. Dias, SC and Franco, OL (2011) Exploring the
pharmacological potential of promiscuous host defense peptides: from natural
screenings to biotechnological applications. Frontiers in Microbiology, 2: 1-14.
Ilnait-Zaragozí, MT, Gato R, Martínez G, Otero-González AJ, Sarracent J, Rodríguez
H, Fernández C, Valdés IC (2011) Efecto del anticuerpo monoclonal 4B3 en la
infección experimental por Cryptococcus neoformans. Revista Cubana de
Medicina Tropical, 63(2):123-129.
López-Abarrategui, C., Alba-Menéndez, A., Silva, ON, Reyes- Acosta, O.,
Vasconcelos, IM., Abreu de Oliveira, JT., Migliolo, L., Costa, MP, Costa, CR.,
Silva, MRR, Garay, HE, Dias, SC, Franco, OL and Otero-González, AJ. (2012)
Functional characterization of a synthetic hydrophilic antifungal peptide derived
from the marine snail Cenchritis muricatus. Biochimie, 94: 968-974.
Simone Maria-Neto, Elizabeth Candido, Diana Ribas, Daniel Souza, Ezequiel Silva,
Lidia Pepe, Anselmo Otero-González, Beatriz Magalhães, Simoni Dias, and
Octávio Franco. Deciphering the magainin-resistance process of Escherichia coli
strains in light the cytosolic proteome (2012) Antimicrobial Agents and
Chemotherapy. 56(4): 5558-11.
Carlos López-Abarrategui, Annia Alba . Menéndez , Loiane A. Lima1, Simone MariaNeto, Ilka M. Vasconcelos, Jose T. A. Oliveira, Simoni C. Dias, Anselmo J.
Otero-Gonzalez and Octavio L. Franco (2012) Screening of antimicrobials from
Caribbean sea animals and isolation of bactericidal proteins from the littoral
mollusk Cenchritis muricatus. Current Microbiology 64: 501-505
Annia Alba, Carlos López-Abarrategui, Anselmo J. Otero-González (2012) Host
Defense Peptides: A Therapeutic Alternative As AntiiInfective Drugs And
Immunomodulatory Therapeutics. Biopolymers: Peptide Sciences 98(4): 251-267.
López-Abarrategui, C; Figueroa-Espí, V; Reyes-Acosta, O; Reguera, E and OteroGonzález, AJ (2013) Magnetic nanoparticles: New players in antimicrobial
peptide therapeutics. Current Protein and Peptide Science, 14(7): 595-606.
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Loiane Lima, Ludovico Migliolo, Clovis Castro, Debora Pires, Carlos LopesAbarrategui, Eveline Gonçalves, Ilka Vasconcelos, Jose Oliveira, Anselmo
Otero-Gonzalez, Simoni Dias and Octavio L. Franco (2013) Identification of a
Novel Antimicrobial Peptide from Brazilian Coast Coral Phyllogorgia dilatata.
Protein & Peptide Letters, 20(10): 1153 – 1158.
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López-Abarrategui C. and Otero-González AJ. (2013) Subcellular proteomics for
understanding Host Defense Peptides mechanism of action. Organelles
Proteomics. 1(1): 7–15
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López-Abarrategui, C., del Monte-Martínez, A., Franco, OL and Otero-Gonzalez,
A.J. (2013) LPS immobilization on porous and non-porous supports as an
approach for the isolation of anti-LPS host defense peptides. Frontiers in
Microbiology. 4: 1-6.
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Otero-González, AJ, Rodríguez-Matheu, I, Franco OL and Sarracent-Pérez, J. (2013)
38 years of hybridoma technology as a source of analytical tools for
immunodiagnostics of infectious diseases. Some contributions developed in
Cuba to improve the original procedures and future prospects. Journal of
Immunological Techniques in Infectious Diseases. 2(4): 1-9.
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Sun, Z.J., Heffron, G., Mcbeth, C., Wagner, G., Otero-González, A.J., Starnbach,
M.N. (2014) Solution structure of a potent antifungal peptide Cm-p5 derived
from C. muricatus. Deposito PDB: 2014-05-14, Status HPUB, entrance code
2MP9.
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Viana, Juliane; Souza, Jessica; Freitas, Camila; Paul, Arghya; Alcaraz, Jarib; Lacorte,
Cristiano; Migliolo, Ludovico; Andrade, Cesar A. S; Falcao, Rosana; Santos,
Nuno; Goncalves, Sonia; Otero-Gonzalez, Anselmo; Khademhosseini, Ali; Dias,
Simoni; L. Franco, Octavio. Antifungal nanofibers made by controlled release of
sea
animal
derived
peptide.
Nanoscale
03/2015;
7(14).
doi:10.1039/C5NR00767D
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López-Abarrategui C, McBeth C, Zhen-Yu JS Heffron G, García M, AlbaMenéndez A, Migliolo L, Reyes-Acosta O, Campos-Dias S, Brandt W, Porzel A,
Wessjohann L, Starnbach M, Franco OL and Otero-González AJ. Cm-p5: an
antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis
muricatus (Gastropoda: Littorinidae). FASEB Journal, 29(8): 3315-25.
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Carlos Lopez-Abarrategui, Anselmo J. Otero-González, Annia Alba-Menéndez,
Edilso Reguera, Octavio Luiz Franco (2015) Chapter: Nanoparticles as a promise
for host defense peptides therapeutics. In: Biological and Pharmaceutical
Applications of Nanomaterials, Edited by Polina Prokopovich, Cardiff
University, UK and Massachusetts Institute of Technology (MIT), USA. chapter
5, CRC Press/Boca Raton: Taylor & Francis., ISBN: 9781482250169. CRC
Press, LLCN: LCCN: 2015008961, USA.
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Fidel E Morales, Hilda E Garay, Daniela F Muñoz, Yarelys E Augusto, Anselmo J
Otero-González,
Osvaldo
Reyes
Acosta,
Daniel
G
Rivera
(2015)
Aminocatalysis-Mediated on-Resin Ugi Reactions: Application in the SolidPhase
Synthesis
of
N-Substituted
and
Tetrazolo
Lipopeptides
and
Peptidosteroids. Organic Letters 17 (11), pp 2728–2731.
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Ludovico Migliolo, Mário R. Felício, Marlon H. Cardoso, Osmar N. Silva, MaryAnn E. Xavierd, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi RocaSubira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J.
Otero-Gonzalez, Sónia Gonçalves, Nuno C. Santos, Octavio L. Franco (2016)
Structural and
functional evaluation of the palindromic alanine-rich
antimicrobial peptide Pa-MAP2. Biochimica et Biophysica Acta (BBA) –
Biomembranes. Volume 1858, Issue 7, Part A, July 2016, Pages 1488–1498.
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Carlos Lopez-Abarrategui, Viviana Figueroa-Espi, Maria B. Lugo-Alvarez, Caroline
D. Pereira, Hilda Garay, Joao A.R.G. Barbosa, Rosana Falcão, Linnavel
Jiménez-Hernández,
Osvaldo
Estévez-Hernández,
Edilso
Reguera-Ruiz,
Octavio L. Franco,3,8, Simoni Campos Dias and Anselmo J. Otero-Gonzalez
(2016) The intrinsic antimicrobial activity of citric acid-coated manganese
ferrite nanoparticles is enhanced after conjugation with the antifungal peptide
Cm-p5. Accepted in International Journal of Nanomedicine
Books:
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Pico, M.C., Giraldino, M.A. y Otero, A. (1999) Inmunología Experimental. Editorial
Félix Varela, Ciudad de La Habana, Cuba, Primera Edición, 300 p. ISBN: 959-070130-2
Otero, AJ (2012) Los Anticuerpos como Herramientas Analíticas y Diagnósticas.
Editorial Académica Española. No.11383 e ISBN 978-3-659-01045-3. LAP
LAMBERT Academic Publishing GmbH & Co. KG. Heinrich-Böcking-Str. 6-8 D
- 66121 Saarbrücken. Germany.
Talks:
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Otero, A. (1989) Purification of a mouse monoclonal antibody by adsorption
chromatography on a matrix of hydroxylapatite obtained from a sea product.
3rd Cuban and International Seminar on Interferon, 1 st Iberoamerican
Congress og Biotechnology. Havana, Cuba.
Otero A. (1996) Impact of Monoclonal antibodies in medical Mycology. 2 nd Latin
American Congress of Mycology, Institute of Tropical Medicine “Pedro
Kouri”, Havana Cuba.
A. Otero (1999) Monoclonal antibodies against infectious agents. Faculty of
Chemical Sciences, Central University of Ecuador sponsored by UNESCO,
Quito, Ecuador.
Otero, A. (1999) Quality control in Animal cell collections. II International
Workshop on Collection of Microbial Cultures, Institute of Tropical
Medicine “Pedro Kouri”, Havana Cuba.
Otero A. (2002) Immunoanalytic tools for the evaluation of enzymatic function. A
Cat ELISA for detection of HIV protease inhibitors. 6 th Latin American
Congress of Immunology. Habana, Cuba.
Otero, A. (2003) “Protection against pathogens by antibody expression in
transgenic plants”. International Workshop of Plant Biotechnology at Center
for Biotechnological Research of Ecuador (CIBE), High Polytechnic School
of the Coast (ESPOL), Guayaquil, Ecuador.
Otero, A. (2003) “Pre-symptomatic immunodiagnosis of Black Sigatoka in
Banana. To be or not to be. The problem of antigen selection”. 3rd CimBios:
Transfer of Biotechnology and Bioinformatics” in the region for the region”.
Center for Scientific Research of Yucatan (CICY), Yucatan, Mexico. Nov
24-26.
Otero, A. (2005) “Monoclonal antibody-based TAS ELISA for the detection of
Mycosphaerella fijiensis antigens. BioVeg 2005. Centro de Bioplantas,
Universidad de Ciego de Avila, Cuba.
Otero A. (2006) Immunodiagnosis for Animal and Plant Diseases. Faculty of
Agronomy and Veterinary. High Polytechnic School of the Coast (ESPOL),
Guayaquil, Ecuador.
Otero A. (2007) Immunomethods for detecting infectious agentes. ViceRectory of
Post graduated studies, Catholic University of Brasilia, Brazil
Otero A. (2009) The Immune System as an Organism Molecular Consciousness.
ViceRectory of Post graduated studies, Catholic University of Brasilia, Brazil
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Otero A. (2009) The Immune System as Information supersystem. University of
Brasilia (UnB), Brazil.
Otero A, López C, Alba A, Lugo MB (2012) Host defense peptides from marine
invertebrates. Evento Humboldt, La Habana, Marzo 2012 (oral presentation)
Otero-Gonzalez, A.J., Carlos López, María B. Lugo, Annia Alba (2012) Host
defense peptides isolated from the marine snail Cenchritis muricatus.
QUIMICUBA 2012, VIII Congreso Internacional de Química, Ingeniería
Química y Bioquímica. La Habana, Cuba (oral presentation) .
Otero-González, A.J., Carlos López-Abarrategui, Annia Alba-Menéndez, Simoni
Campos Dias, Octavio Luis Franco (2013) Host Defense peptides isolated
from the litorinic snail Cenchritis muricatus. Symposium 1: Novel Insights
Over Peptides for Drug Development, XLII Annual SBBq Meeting Scientific Program 18.05.2013 a 21.05.2013, Foz do Iguaçu, Paraná, Brazil
(oral presentation) .
Otero-González, A.J. (2013) Antimicrobial peptides from marine invertebrates.
Departamento de Química Bioorgánica. Leibniz Institute for Plant
Biochemistry, Halle (Saale), Germany.
Otero-González, A.J. (2013) Péptidos sintéticos con actividad antifúngica
derivados del molusco litorínico Cenchritis muricatus. Centro Internacional
de Investigación en Salud de Barcelona, Hospital Clínic-Universitat de
Barcelona, España
Conferences and Research Visits:
12/1994-02/1995:
Lectures at Equatorial Institute of Social Security Hospital, Guayaquil,
Ecuador.
05/1995-07/1995, 06/1996-07/1996, 05/1997-07/1997:
Lectures at Center if Regional Research “Hideyo Noguchi”
Merida, Yucatan, Mexico.
08/2002-11/2002, 06/2003-09/2003, 10/2004-12/2004,
Lectures at Center for Biotechnological Research of Ecuador (CIBE),
High Polytechnic School of the Coast (ESPOL), Guayaquil, Ecuador.
03/2000-04/2000:
Working visit for project application: Harvard School of Public
Health, Boston, Ma, USA (Sponsor: Dr. Professor John David,
Harvard School of Public Health, Harvard University, Boston, USA.
03/2011-04/2011;
04/12-05/2012:
Research project at Harvard Medical School, Boston, MA, USA
(Sponsor: Dr. Professor Michael Starnbach).