Cyclic AMP Sensor EPAC Proteins and Their Role in
Cardiovascular Function and Disease
by Frank Lezoualc’h, Loubina Fazal, Marion Laudette, and Caroline Conte
Circulation Research
Volume 118(5):881-897
March 4, 2016
Copyright © American Heart Association, Inc. All rights reserved.
Pharmacological and functional properties of exchange protein directly activated by cAMP
(EPAC) agonists and antagonists.
Frank Lezoualc’h et al. Circ Res. 2016;118:881-897
Copyright © American Heart Association, Inc. All rights reserved.
Exchange protein directly activated by cAMP (EPAC) multidomain proteins and their interacting
partners.
Frank Lezoualc’h et al. Circ Res. 2016;118:881-897
Copyright © American Heart Association, Inc. All rights reserved.
Mechanism of exchange protein directly activated by cAMP (EPAC) activation. cAMP is produced
from ATP by adenylyl cyclase (AC) in response to Gαs-coupled G protein–coupled receptors
(GPCRs) stimulation and activates its classical downstream effector, cAMP-dependent protein
kinase A (PKA).
Frank Lezoualc’h et al. Circ Res. 2016;118:881-897
Copyright © American Heart Association, Inc. All rights reserved.
Chemical structures of exchange protein directly activated by cAMP (EPAC) ligands.
Frank Lezoualc’h et al. Circ Res. 2016;118:881-897
Copyright © American Heart Association, Inc. All rights reserved.
Overview of key exchange protein directly activated by cAMP (EPAC) functions in the
vasculature.
Frank Lezoualc’h et al. Circ Res. 2016;118:881-897
Copyright © American Heart Association, Inc. All rights reserved.
Exchange protein directly activated by cAMP (EPAC) signaling in cardiac remodeling.
Frank Lezoualc’h et al. Circ Res. 2016;118:881-897
Copyright © American Heart Association, Inc. All rights reserved.