APSTIPRINĀTS
Rīgas Stradiņa universitātes
Cilvēka fizioloģijas un bioķīmijas katedras
Sanāksme 10.07.2014., protokola nr. 13.14.-4/3
http://aris.gusc.lv/2014-15MFArz1LekcLdVK1sem.doc
Time Table Schedule for MF I-st course Medical Students
Subject“Medical Chemistry ".
17 weeks 1. first semester 2014 year.
Lectures 9 hours; Practical work 51 hours.
3 Credit points all 17 groups Nr. 1 ÷ Nr.17.
Kolokvijs I nedēļā 5 no 29.septembra līdz 05.oktobrim.
Kolokvijs II nedēļā 9 no 27.oktobra līdz 02.novembrim.
3 auditorija piektdienā no1330÷1415 deviņas lekcijas no12.IXlīdz 12. XII
Lekcijas deviņas reizes Piektdienā nedēļās 2.,
4.,
5.,
6., 7.,
9., ,
10.
12.,
14.
12.IX; 26.IX; 03X; 10.X; 17.X;31.X; 07.XI; 21.XI; 05.XII
Nr.
Week
1
01-07.september
2
08-14. september
3
15-21. september
4
22-28. september
Lecture
1h 1
1h 2
5 29-30september-5. oc tober 1h 3
I Coll
Nr.
Week
Lecture
10
03-09.november
11
10-16. november
12
17-23 november
13
24-30. november
14
01-07. december
6
06-12. october
1h 4
15
08-14. - december
7
13-19. october
1h 5
16
15-21. december
8
20-26. october
9
27-31-2 october -nov
17
1h 6
II Coll
05-11.
1h 7
1h 8
1h 9
january
20. january 2015.year
Pamatojoties uz studentu aptaujas rezultātiem:
Lekcijas 3 auditorija piektdienā no1330÷1415 deviņas lekcijas
08 -12.IX -14XI
22-26.IX -28XI
29. IX -03X-05X
06-10. X -12X
13-17. X -19X
27-31.X -02XI
03-07. XI -09XI
17-21. XI -23XI
01-05. XII -07XII
Cilvēka fizioloģijas un bioķīmijas katedras docents Āris Kaksis: 22.aprīlī 2014.gadā
III Coll
Tusday
Exam
Time schedule for MF I-st course Subject “Medical Chemistry " 3 credit points. 17 weeks
1. first semester 2014 year. Spring 9 Lectures; Practical work 51 hours. 164÷178 all 15 groups.
Lecture Hall Nr.3
Labroom Nr 406, 409, 410
Labroom Nr 406, 409, 410
Nr. Week
Theme of lecture 1 hour 9 lectures On first-ground floor
Laboratory practical work
15
30
14
Lecture
Hall
Nr.3
02.II÷26. V each Friday 13 ÷
3 hours per week
1.
01-07. Calculation of different kinde concentrations w%, CM, CN of products from mas fraction to
september molarity. Copounds react in equivalent amounts n1=n2 and converting reagent C to equivalent
Install applica- amount n=C•V. ConCentratia – latin names – Common Amaount in each point of body is the
tions on Your same. Blood plasma oxygen [O2] = 6 10-5M, [glucose] = 5mM, pH = 7.36 or [H+] = 10-7.36 M
computer: Raswin, ISIS Draw4, ChemScape, FireFox, Mage http://aris.gusc.lv/index.html;For Windows
in adress http://aris.gusc.lv/InstallChemistryPC.html and avilable for MacOSX MacBook On Parallel
Desktop http://aris.gusc.lv/InstallChemistryMac.htmlruningXP2WindowsRaswin,ISISDraw,ChemScape
Permanganatometry
Chemical Thermodynamics I,II
Ox – Red reactions.
(oxsidimetri).Practical
2.
08.-14. Equilibrium Coservation of mass and
Nernst’s equation
energy law, spontaneous and nonspo- Determination amount of emploiment of Ox-Red reaction
equilibrium.
september ntaneous process.Scientific importa- reductants and oxidants
nce chemical methodesrecov ering d isease and early diagnosis, for analyse racional health car.
I law of Thermodynamics neutralization reaction Heat is exothermic-∆Hr<0 and energy
3. 15.-21.
change exoergic ∆Gr=∆Hr–T·ΔSr<0 negative. Spontaneous reaction condition Gibs free
september energy change negative. Thermodynamically forbidden reactions: Green plants Photosynthesis
Protein synthesis in Ribosomes peptide bond formation reaction: ala + gly=ala-gly+ H2O
Osmosis and colligative properties
Equilibria Thermodynamics II law. Free energy G= μ
22.-28.
4.
water solutions. Oxygen O2 and
Chemical Potential of water mixtured Compounds
september
water H2O transport enzymes
molfraction X = n/(n+nH2O); ∆G/∆n = μ = G° + ln(X) free
energy of one mol. Le Chatelier theorem for life sciences
acrose membranes aquqporines.
29-30-05. Water dissociation and association I colloqium. Colligative Osmotic presure π=iCMRT
5. september equilibria pH=7. Strong and week properties water solutions Crioscopic constant Kcr=1,86 ,
electrolites ionic activity. Acids and bases pH=-log([H+]). Ebulioscopic Keb=0,52
october
6.
7.
8.
9.
Henderson- Haselbah equation
Enzyme and Biological Seminar pH calculation acid,
06.-12. pH =pKa +lg(nsalt/nacid)
buffer systems. Carbonic
base and salt solutions:
october
blood pH=7.36 depends on ratio anhydrase CA made
pH= -logCMαz;pOH=-logCMαz
[HCO3-]/[CO2]= 2.036/1 alkaline H2O+CO2=H++HCO3- pH=14-pOH; pH= -log K C
a
reserve is 2.036 over 1 to make Brenstad Acid H2O+CO2
pOH= -log K b C
7.36=pH=7.025+lg([HCO3-]/[CO2]) Base HCO3- equilibrium
Types of Elctrode potentials.
Electrode types and potentials E. Potenciometric acid and
13.-19. Membrane potencial. Ionic chanels
base pH metric titration. E=Eo+0.0591/n log[Ox]/[Red]
october H+, Na+, HCO - potential forming
3
enzymes.
Emembr=0.0591/n logCout/Cin
Buffer Solution composition nsalt/nacid. Henderson- Haselbah equation pH =pKa +lg(nsalt/nacid)
20.-26.
Buffer volume Vbuffer , pH, ∆pH and buffercapacity βac, βb calculation
october
n
 equivalent  mol 
β=
=
.
pH  Vbuffer 
Liter

Blood Buffersystems Bicarbonate carbonic anhydrase CA enzyme
Building of atoms and covalent
II colloqium Water dissotiation and ionisation, pH,
27.-31-2. nonpolar, polar, ionic bond. Donor
buffersolution. Protolitical acid, base theory. Salt
october
acceptor Coordinative bond.
hydrolise. Neutralisation. Electrode Potencials .
november
Hydrogen bond.WanDerWalls interaction.Lipids
Laboratorium Nr A406, A409, A410
Laboratorium Nr A406, A409, A410
At start semester Install applications on Your computer: Raswin, ISISDraw4, ChemScape, FireFox, Mage
http://aris.gusc.lv/index.html; for PC Windows computer http://aris.gusc.lv/InstallChemistryPC.html
and for MacOSX MacBook runing Parallel Desktop XP2 in adress http://aris.gusc.lv/InstallChemistryMac.html
3.-9. Velocity of reactions depends on Complex compound structuer and building, formation,instability
colliding molecule geometry,
and destruction. Complex compounds stabilty.
10 Nov2+
embr
concentration, temperature.
Fe ,Fe3+,Cu2+, Zn2+,Ca2+,Mg2+,Na+,K+,H+ bioorganic
Activation energy. Catalysis.
coordinative buildig structures 2º,3º,4º in life molecules
Enzymes
10-16 Optical methods of analyse: A=log(Io/I) absorbtion A of light intensity Io/I. Photocolorimetric B2
11 Nov- concentration A=aCl. Chemical kinetics. Reaction velocity depend on concentration and temperature.
ember
Enzyme activity and importance in life of Human organism.
Proteins Intermolecular forces: Monosacharides, disacharides chemical building and reactivity
1217-23.1)Hydrogen bond,2)Hydrophobic bond, properties. Physiologically important carbohydrates in adress:
Nov- 3) Salt bridges, 4) Disulfide bonds, http://aris.gusc.lv/ChemFiles/Saccharides/SSViewer/SSVFrames
em- 5) Coordinative. Electron acceptors et.html
ber metalic central atom (ion), donors Sacharides:Disacharides,PolysacharidesHomopolysacharides,
attached atom O and N containing Heteropolysacharides, structures Lab Work task paper:
groups ions,molecules - ligands. http://aris.gusc.lv/06Daugavpils/Engl/1SaccharideLabA.doc
1st.Home Work 20 amino acids
http://aris.gusc.lv/06Daugavpils/Lat/Amineac20L.doc
Fisher projections
Harper’s Biochemistry List Literature. number 7!
Fill Up correct the Table 3-1 on
http://aris.gusc.lv/ChemFiles/MCDB108A/mcdb108a.html
15-16 pages to L-Amino Acids
LabWork task paper 1: Mucin presence proof in enzyme amilase of salive.Phosphate proof in caseine
13 24-30.hydrolsate. Physiologically important:heparin,heparan,dermatansulfate,condroitin,hialuronate, mucin:
Nov- http://aris.gusc.lv/06Daugavpils/Lat/ProteoGlycans.doc; investigation properties:
em- http://aris.gusc.lv/ChemFiles/Saccharides/PolySaccharides/HyalurChondroitHeparKeratMucHTM/0Gl
ber ycoProteinComponents.html; Body guard enzyme Glycoproteins immunoglobulin functions:
http://aris.gusc.lv/06Daugavpils/Engl/ImmunoGlobulA.doc Blood groups A,B,AB,O oligisacharides.
Lipids:Phosphatidyl Choline 1/3 Absorbtion-Desorbtion Enzyme O2 Oxi-,deoxi-,carbomonoxi14 01-07 membrane compo, 1/3membrane CO & Fe+3metoxi-hemoglobin specters. Chlorohemin crystalins.
Cholesterol, 1/3membrane integral Hemoglobin, http://aris.gusc.lv/06Daugavpils/Engl/HromoProteinsA.doc
DeProteins. Lipoproteins Albumin, myoglobin maintaines safe stored oxygen amount as blood
cem- Chylomicrones, VLDL,LDL, HDL reserve 40 times over O2 concentration in plasma [O2]=6·10-5 M
ber 2nd HomeWork draw formula and Chromoproteins-enzymes: myoglobin,hemoglobin O2 in human
call phisiologicaly relevent lipids, bodies adsorbtion-desorbtion enzymes. Eric Marz studies:
carbonic acids and metabolites. http://aris.gusc.lv/ChemFiles/hemoglobEricMarzUMas/INDEX.htm
http://aris.gusc.lv/06Daugavpils/Eng http://aris.gusc.lv/ChemFiles/ChromoHem/HbOxDeoxCO/Huma
nMeasure/O2Solutions.doc
l/carboxylicAcidsTest.doc
PhosphoLipid-Lecithine,
Fatty
Acids,
Glicerol,
Choline, Phosphate, Cholesterol, Cell Bilayer Membranes.Task & helping
08-14.
material
in
address:http://aris.gusc.lv/06Daugavpils/Engl/PhosphLipidBilayerMembran.doc;
15
De- http://aris.gusc.lv/06Daugavpils/Engl/LipdBiLayerMembran.doc
cem- http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/Cholesterol/CholesterolMembran.html ;http://aris.gusc.
lv/ChemFiles/BilipidCholine/Membrane/Cholest5ene3-20diol/Cholesterol5Membran.html
ber
Lipo-proteins: Albumin, Chylomicrons, VLDL LDL and HDL
DNA & RNA components. http://aris.gusc.lv/06Daugavpils/Engl/NucleoProteinsA.doc tRNA-Phe
16 15-21 structure, http://aris.gusc.lv/ChemFiles/DnaMarzHTM/INDEX.HTM functions, nucleosomes structure
Dec http://aris.gusc.lv/ChemFiles/CarnegieMellonUChem/Programs/Courses/BiochemMols/tRNA_Tour/tRNA_Tour.html
histones on hromosomes task: http://aris.gusc.lv/06Daugavpils/Engl/NucleoSomeA.doc studies in:
http://aris.gusc.lv/ChemFiles/CLUnucleosome/nucleosome.htm
in adress Nucleo proteins: DNA, RNA, tRNA . Phosphate Proof in yeast hydrolizate LabWork task
http://aris.gusc.lv/NutritionBioChem/38DNSLab310311.doc paper: Base pares A=T G≡C on DNA &
on RNA strands A=U G≡C. Nucleosome 8 histones.
05-11 III colloqium Coordinative compound. Optical methods of analyse: A=log(Io/I); A=aCl. Reaction
17 Januvelocity. Enzyme catalysts. Blood groups A,B,AB,O oligisacharides.
ary Hemoglobin,myoglobin and carbo anhydrase ENZYMES driven O2 oxygen carbon(IV) oxide CO2
exchange HOMEOSTASIS in human body.
Phosphatidyl Choline, Cholesterol, Lipids, Membrane building and
Physiological functions in human body HOMEOSTASIS.
Lipoproteins functions in human body HOMEOSTASIS. Albumin, Chylomicrons,VLDL,LDL & HDL.
Nucleoproteins DNA, tRNA,mRNA-Codons, Nucleosome 8 Histones Physiological functions.
RSU dep. Human Physiology and Biochemistry responsible teacher - asist.professor, chem.dr. Āris Kaksis.
lecturer Agnese Brangule and lecturer Mihail Haļitov
Final exame January session 20.01.2015. on Tusday in LectureHalls Nr2 and Nr3 Good luck!
Winter Hollydays since 22.12. 2014. to 04.01.2015.
L I T E R A T U R E.
1. Rauhvarger, A. © 1993. General Chemistry. For medical Students. Riga, AML. Part I, II, III, IV.
http://aris.gusc.lv/GenChem93/ChemistryRauhvarger.html
2. A.Rauhvargers. "Vispārīgā ķīmijā",Rīga , © 1996. In Latvian for medical students.
3. Ā.Kaksis. "Medical chemistry" lectures © 2014 Rigas Stradin’s University
INTERNET : http://aris.gusc.lv/ Med. Biochemistry Data Base RSU room A403, © 2011
http://aris.gusc.lv/ChemFiles/ComplexCompounds/. Enjoy the studes at home page too acid-base indicators:
http://aris.gusc.lv/ChemFiles/AcidBaseIndicators/index.html
4. Ā.Kaksis. " Biochemistry Thermodynamics"© 2006,
http://aris.gusc.lv/BioThermodynamics/BioThermodynamics.html
5. Ā.Kaksis. " Biological oxidation-reduction reactions"© 2006 ,
http://aris.gusc.lv/BioThermodynamics/OxRedBiological.html
6. INTERNET address in Medical Biochemistry:http://aris.gusc.lv/Chemistry.html«THE site for Medical
Biochemistry Students»
Default Page on Firefox Browser using ChemScape plugin also on local RSU network in room A403,
7a. HomeWork task fill up Harper’s table: http://aris.gusc.lv/06Daugavpils/Engl/Amineac20Ld.doc
7b. Home Work perform in table independently or using on Your computer aminoacid frames on FireFox:
http://aris.gusc.lv/ChemFiles/MCDB108A/tw-amn/aasframes.htm
8. «The Saccharide Viewer » for studies of Saccharides, Glycoproteins and Proteoglycans.
http://aris.gusc.lv/ChemFiles/Saccharides/SSViewer/SSVFrameset.html
9. «The Lipid Viewer » for studies of Lipids Fatty Acids, Triglycerides, Phospholipids, Sphingolipids,
Eicosanoids, « Membrane Marz» Membrane bi layer, Steroids.
10. Proteoglycans, Glycoproteins and imunoglogulin:
http://aris.gusc.lv/ChemFiles/Saccharides/PolySaccharides/HyalurChondroitHeparKeratMucHTM/0GlycoProteinComponents.html
«The Immunoglobulin IgG1 Glycoprotein»http://aris.gusc.lv/ChemFiles/ChimAntibodyMarz/INDEX.htm
11. «Hemoglobin Eric Marz Univ.Massachusets»«1MBODeOxyLopez.kin»«2HCOProTour8.kin»for studies of
Heme and its containing proteins, http://aris.gusc.lv/ChemFiles/ChromoHem/Heme/HEMdabigs.tgf
http://aris.gusc.lv/ChemFiles/ChromoHem/MyoGlobOxDeoxCoBiliverdin/1MBODeOxyLopez.kin
http://aris.gusc.lv/ChemFiles/ChromoHem/HbOxDeoxCO/2HCOProTour8.kin
http://aris.gusc.lv/ChemFiles/hemoglobEricMarzUMas/INDEX.htm
12. «DNAstructurEricMartz»http://aris.gusc.lv/ChemFiles/DnaMarzHTM/INDEX.HTM,
«tRNATourPhe Carnegie Mellon Univ.» for studies of DNA and tRNA
http://aris.gusc.lv/ChemFiles/CarnegieMellonUChem/Programs/Courses/BiochemMols/tRNA_Tour/tRNA_Tour.html
http://aris.gusc.lv/ChemFiles/CLUnucleosome/nucleosome.htm
13. «Phospholipid Bilayer Membrane»,«Cholesterol Steroid Lipid» Riga Stradin’s University © 2014,
http://aris.gusc.lv/06Daugavpils/Engl/PhosphLipidBilayerMembran.doc
and helping material in address:http://aris.gusc.lv/06Daugavpils/Engl/LipdBiLayerMembran.doc
http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/Membrane/membrane/Membrane.html,
http://aris.gusc.lv/ChemFiles/BilipidCholine/Membrane/Cholesterol/CholesterolMembran.html
14. «Biochemistry of Medicinals» Minnesota University prepared course based on Stryer Biochemistry ,
department of Human Physiology and Biochemistry http://aris.gusc.lv/Minesot-Riga.html.
15. David L. Nelsone, Michael M. Cox. Lehniger Principles of Biochemistry. © 2005. W.H.Freeman
16. F. Horn, G. Lindenmeier u.a. 3.,grundl.überarb.Aufl. © 2005 Biochemie des Menschen 640 S.,
1160 Abb., kart.
Das Lehrbuch für das Medizinstudium
17. Robert K. Murray, Daryl K. Granner, Victor W. Rodwell. © 2006 by. Harper's Illustrated
Biochemistry. 27th Edition. McGraw-Hill`s ACCESSMEDICINE, Inc. 23MB.
18. Physical Chemistry ATKINS 7Ed P.W.Atkins Oxford © 2006 Oxford University Press 480p.18. CRC
Handbook of Chemistry and Physics 87Ed DavidR.Lide New York ©2007 Taylor and Francis Group LLC 2388p
19. Krieg, B. © 1990. Chemie fûr Mediziner. 5th ed. Berlin, Gerike GmbH.
20. Ā.Kaksis. RSU Medical chemistry subject in Latvian "Vispārīgajā ķīmijā"174.lpp. I.Kazuša,©2012:
and http://aris.gusc.lv/VisparigaKimija5A.doc 180.lpp. elektronic issue © 2012 in Latvian.
21. Reginald H. Garrett, Charles M. Grisham. 1995. Biochemistry. University of Virginia.
first edition. Saunders College Publishing Harcourt Brace College Publishers.
© 1995 by Saunders College Publishing.
_1150 p.
22. David A. Haris. 1995. Bioenergetics at a Glance . University of Oxford . Department of
Biochemistry.Martson Book Services, PO Box 87, Oxford OX2 0DT UK© 1995 by Blackwell Science Ltd.
Time Table Schedule for MF I-st course Medical Students Subject“Medical Chemistry "
Nr.
Laboratory practical work
Lecture
1. 01-07
Concentration expresion forms
september
2. 08-14
Oxidation-Reduction reactions
1.Thermodynamikcs
september
3. 15-21
Reaction Thermodynamics
september
4. 22-28
Chemical equilibrium
2.Osmose-coligative properties
september
5. 29-30-5
october
I Colloquium
3.Water dissociation pH,pOH,pKw
september6. 06-12
Hydrogen exponence pH appreciation
4.Electrode potencial Ox/Red forms
october
7. 13-19
Acid & base reaction, balance pH
5.Buffer solution blood pH=7,36
october
8. 20-26
Buffer solutions & blood pH=7,36
october
9. 27-31-2
II Colloquium
6. Atoms & biomolecul structure
october-nove
10. 03-09
Coordinative & complex chem.bond
7. Kinetics,katalize, enzymes
november
11.10-16
B2 vitamin spectrometry, molecules
november
Reaction velocity
12. 17-23
Carbohydrates:
8. Five InterMolecular Forces
november
monosacharides,polysacharides
13.24-30
Glycoproteins, amylase mucins
november
14. 01-07
Myoglobin ,Hemoglobin, Sickle Cell anemia
9. Lipīds, LipoProteins, Membranes
december
15.08-14 PhosphoLipīds Bilayer Membranes Cholesterol
december LipoProteins Chilomicrons, VLDL, LDL, HDL
16.15-21
Nucleoproteins DNA,tRNA,mRNA-Codons, Nuleosome 8 Histones
december
17.05-11
III Coll
january
Tusday20. january 2015.year Lecture Hall Nr2 & Nr3 Exam Medical Chemistry