Dianqing Sun PhD
Affiliation:
University of Hawaii
Pharmaceutical Sciences
"Cancer","Infectious and Immunological Diseases"
Title: Associate Professor
Rank: Associate Professor
Address:
200 W. Kawili Street
Hilo, HI 96720
Contact:
Email: [email protected]
Telephone: 8089332960
Narrative
Research in Dianqing Sun's laboratory focuses on the design and synthesis of novel small molecule
and natural product based anti-infective and anti-cancer agents. The chemical approaches include
classical organic synthesis, parallel and high-throughput chemistry, solid-phase organic synthesis,
followed by traditional medicinal chemistry optimization of the emerging lead compounds.
Other Positions
Title
Associate Professor
Institution
University of Hawaii Cancer Center
Department Natural Products & Experimental Therapeutics
Division
Awards and Honors
2005
- GRC on Combinatorial Chemistry Graduate Fellowship Award
2011
University of Hawaii at Hilo - Excellence in Teaching Award for Pharmaceutical Sciences
2012
- Faculty Travel Grant, ACS Division of Organic Chemistry
2014
- GRC on New Antibacterial Discovery & Development PUI fund award
Publications
1.
Chai X, Youn UJ, Sun D, Dai J, Williams P, Kondratyuk TP, Borris RP, Davies J, PubMed
Villanueva IG, Pezzuto JM, Chang LC. Herbicidin congeners, undecose nucleosides
from an organic extract of Streptomyces sp. L-9-10. J Nat Prod. 2014 Feb 28;
77(2):227-33.
2.
Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J,
Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB.
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome
native drug efflux. Nat Med. 2014 Feb; 20(2):152-8.
3.
Tsutsumi LS, Owusu YB, Hurdle JG, Sun D. Progress in the discovery of treatments for PubMed
C. difficile infection: A clinical and medicinal chemistry review. Curr Top Med Chem.
2014; 14(1):152-75.
4.
Park EJ, Shen L, Sun D, Pezzuto JM. Inhibitory effect of a callophycin A derivative on PubMed
iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7
cells. J Nat Prod. 2014 Mar 28; 77(3):527-35.
5.
Lin H, Annamalai T, Bansod P, Tse-Dinh YC, Sun D. Synthesis and antibacterial PubMed
evaluation of anziaic acid and analogues as topoisomerase I inhibitors.
Medchemcomm. 2013 Dec 01; 4(12).
6.
Yu X, Sun D. Macrocyclic drugs and synthetic methodologies toward macrocycles. PubMed
Molecules. 2013 May 24; 18(6):6230-68.
7.
Shen L, Maddox MM, Adhikari S, Bruhn DF, Kumar M, Lee RE, Hurdle JG, Lee RE, Sun PubMed
D. Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular
and antibacterial agents. J Antibiot (Tokyo). 2013 Jun; 66(6):319-25.
8.
Lin H, Sun D. RECENT SYNTHETIC DEVELOPMENTS AND APPLICATIONS OF THE PubMed
ULLMANN REACTION. A REVIEW. Org Prep Proced Int. 2013; 45(5).
9.
Yu X, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D. Synthesis of 2-arylindole PubMed
derivatives and evaluation as nitric oxide synthase and NF?B inhibitors. Org Biomol
Chem. 2012 Nov 28; 10(44):8835-47.
PubMed
10. Pieroni M, Girmay S, Sun D, Sahu R, Tekwani BL, Tan GT. Synthesis and structure- PubMed
activity relationships of lansine analogues
ChemMedChem. 2012 Nov; 7(11):1895-900.
as
antileishmanial
agents.
11. Sun D, Hurdle JG, Lee R, Lee R, Cushman M, Pezzuto JM. Evaluation of flavonoid and PubMed
resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.
ChemMedChem. 2012 Sep; 7(9):1541-5.
12. Shen L, Simmons CJ, Sun D. Microwave-assisted synthesis of macrocycles via PubMed
intramolecular and/or bimolecular Ullmann coupling. Tetrahedron Lett. 2012 Aug
08; 53(32):4173-4178.
13. Shen L, Park EJ, Kondratyuk TP, Guendisch D, Marler L, Pezzuto JM, Wright AD, Sun PubMed
D. Design, synthesis, and biological evaluation of callophycin A and analogues as
potential chemopreventive and anticancer agents. Bioorg Med Chem. 2011 Nov 01;
19(21):6182-95.
14. Shen L, Sun D. Total synthesis and structural revision of engelhardione. Tetrahedron PubMed
Lett. 2011 Aug 31; 52(35):4570-4574.
15. Brown JR, North EJ, Hurdle JG, Morisseau C, Scarborough JS, Sun D, Korduláková J, PubMed
Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE.
The structure-activity relationship of urea derivatives as anti-tuberculosis agents.
Bioorg Med Chem. 2011 Sep 15; 19(18):5585-95.
16. Sivendran S, Jones V, Sun D, Wang Y, Grzegorzewicz AE, Scherman MS, Napper AD, PubMed
McCammon JA, Lee RE, Diamond SL, McNeil M. Identification of triazinoindolbenzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis
enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorg
Med Chem. 2010 Jan 15; 18(2):896-908.
17. Sun D, Xu H, Wijerathna SR, Dealwis C, Lee RE. Structure-Based Design, Synthesis, PubMed
and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate
Derivative as Ribonucleotide Reductase Inhibitors. ChemMedChem. 2009 Oct;
4(10):1649-56.
18. Hurdle JG, Yendapally R, Sun D, Lee RE. Evaluation of analogs of reutericyclin as PubMed
prospective candidates for treatment of staphylococcal skin infections. Antimicrob
Agents Chemother. 2009 Sep; 53(9):4028-31.
19. Sun D, Scherman MS, Jones V, Hurdle JG, Woolhiser LK, Knudson SE, Lenaerts AJ, PubMed
Slayden RA, McNeil MR, Lee RE. Discovery, synthesis, and biological evaluation of
piperidinol analogs with anti-tuberculosis activity. Bioorg Med Chem. 2009 May 15;
17(10):3588-94.
20. Synthesis, optimization and structure-activity relationships of 3,5-disubstituted PubMed
isoxazolines as new anti-tuberculosis agents. Eur J Med Chem. 2009 Feb; 44(2):46072.
21. Sun D, Jones V, Carson EI, Lee RE, Scherman MS, McNeil MR, Lee RE. Solid-phase PubMed
synthesis and biological evaluation of a uridinyl branched peptide urea library.
Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6899-904.
22. Tangallapally RP, Sun D. Discovery of novel isoxazolines as anti-tuberculosis agents. PubMed
Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6638-42.
23. Sun D, Lee RE. Solid-phase synthesis of a thymidinyl dipeptide urea library. J Comb PubMed
Chem. 2007 May-Jun; 9(3):370-85.
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