PUBLIC HEALTH: Lecture Objectives #1: Intro Know the many different definitions of public health and the 2 main components of public health Comprehensive science with broad spectrum coverage American Public Health Association definition: o “Public Health is prevention.” Public health is the practice of preventing disease and promoting good health within groups of people, from small communities to entire countries. o “Public Health is policy development and population health surveillance.” Public health professionals rely on policy and research strategies to understand issues such as infant mortality and chronic disease in particular populations From What is Public Health .org: o Public Health is the science of protecting and improving the health of communities through education, promotion of healthy lifestyles, and research for disease and injury prevention o Public health professionals analyze the effect on health of genetics, personal choice, and the environment in order to develop programs that protect the health of your family and community 2 main components of PH o Disease prevention through surveillance and healthy behaviors o Deals with populations of people, not individuals Understand the foundation of public health Foundation of public health is based on 6 pillars categorized into 3 categories (A,B,C) Category A: Tools and science of public health o Epidemiology o Statistics Category B: Health science research and investigation o Biomedical sciences o Environmental health sciences Category C: Social and medical care system o Social and behavioral science o Health care administration, medical care system Discuss the difference between early and modern focuses of public health and give examples of each EARLY focuses of PH: Chinese developed variolation around 1000 BC o Inhaling dried crusts from smallpox lesions (first example of immunization) 1820s, Edward Jenner and cowpox vaccine--protected against smallpox 14th century, Black Death in Europe o Burning parts of cities destroyed rodent infestations; Quarantine helped mitigate spread Epidemiology o John Snow and cholera epidemics in London; Identified source of outbreak as contaminated water well MODERN focuses of PH: By 20th century, focused more on chronic diseases Cancer and heart disease o Smoking and lung cancer; Diabetes and obesity Still focus on infectious diseases in developing countries o Malaria, TB, cholera in Haiti Recent return to new and emerging infections in U.S. o AIDS epidemic in 1980s; SARS, H1N1, Antibiotic resistance (MRSA), Food-borne outbreaks (Salmonella, Listeriosis) Know the 5 key focus areas included in the CDC’s strategic plan, and what the CDC’s main role is in each area 1. Preparedness and prevention a. Develop public health guidelines, support, technical assistance, provide self-assessment tools 2. Detection and surveillance a. Integrated surveillance for reporting of illnesses from biological and chemical terrorism; ERs, medical personnel, poison control centers 3. Diagnosis and characterization of biological and chemical agents a. Creation of multilevel laboratory response network for bioterrorism (LRNB)** i. 4 levels, links clinical labs to public health agencies, capability of testing for biowarfare agents, rapid-response and advanced technology laboratory, provides 24-7 diagnostic confirmation and reference support 4. Response a. Epidemiologic investigation, medical treatment, prophylaxis; Initiation of prevention or environmental decontamination 5. Communication a. State-of-the-art communication system that will support disease surveillance i. Rapid notification and information exchange, dissemination of diagnostic results and information, coordination of emergency response activities ** Differentiate between covert and overt terrorist attacks based on most likely agents involved and the most likely first responders OVERT attacks: Quick effect of terrorism o 9/11, bombings, chemical attacks--Chemical agents absorbed via inhalation or skin, symptoms usually immediate and obvious Historically more concern for these (Plans in place) Such attacks elicit immediate response from police, fire, EMS personnel COVERT attacks: Delay between exposure and onset of illness (incubation)--No immediate impact o Release of smallpox, pts appear in Drs' offices, clinics, ER during 2nd wk with flu-like symptoms. Then pts develop papular rash, becomes pustular, deaths Short window of time between first cases and second wave Victims identified by physicians or other primary health-care providers Public health officials need to determine if attack occurred, identify organism, prevention strategies Discuss the steps in preparing for biological and chemical attacks Communication programs to deliver information o Enhance bioterrorism-related education and training for health-care professionals o Prepare educational materials for public Enhance epidemiologic capacity to detect and respond to biological attacks o Support development of diagnostic tests o Establish surveillance for microbial strains (Including unusual or drug- resistant strains) o Supply reagents to public health agencies o Encourage research on antiviral drugs and vaccines (Stockpile appropriate vaccines and drugs) Education o Enhance awareness of chemical terrorism (EMS, police, firefighters, physicians, nurses) o Educational materials for public during and after a chemical attack Detection/prevention o Develop and provide bioassays for detection and diagnosis o Enhance epidemiologic capacity for detecting and responding o Stockpile chemical antidotes Know the Category A Critical biological agents and the different categories of chemical agents *Biowarfare Agents are classified into 3 categories: Category A (high-priority agents) o Easily disseminated or transmitted between people o High mortality rates, potential for major public health impact o Might cause public panic and social disruption o Require special action for public health preparedness Category B o Moderately easy to disseminate o Moderate morbidity and low mortality rates o Require enhancements of CDC's diagnostic capacity Category C o Availability, easily produced and disseminated o Potential for high morbidity and mortality rates Category A agents: o o All respiratory or blood transmission Agents/Diseases o Anthrax (Bacillus anthracis) o Botulism (Clostridium botulinum toxin) o Plague (Yersinia pestis) o o o Smallpox (variola major) Tularemia (Francisella tularensis) Viral hemorrhagic fevers (filoviruses [e.g., Ebola, Marburg] and arenaviruses [e.g., Lassa, Machupo]) #2: Bioterrorism Agents - review entire PowerPoint for these questions Know the criteria for classification of pathogens into the Categories of Bioterrorism Agents *refer to 3 Categories above Know the Category of Bioterrorism Agents for each pathogen discussed. Know the route of transmission that would be seen in a bioterrorism case scenario for each pathogen discussed. Know the diagnosis (including laboratory tests) and treatment and/or prevention for the pathogens where discussed. #3: Nosocomial Infections Define HAI and give examples of endogenous and exogenous sources of infection. o o o Healthcare Associated Infection (HAI). The CDC defines an HAI as a localized or systemic condition resulting from an adverse reaction to the presence of an infectious agent(s) or its toxin (s). Endogenous: from the patient’s body Exogenous: sources external to the patient (personnel, equipment, visitors, hospital environment) Explain the contributions made by Ignaz Semmelweis and Joseph Lister to the field of infection control. Ignaz Semmelweis: o o o Dr. Semmelweis determined that physicians going directly from autopsies to labor and delivery were infecting their patients. He suggested that physicians wash their hands before delivering babies which resulted in decreased infection and mortality. He is credited with instituting the first standards of infection control. Joseph Lister: o Used carbolic acid to chemically sterilize surgical equipment and bandages. List the top 4 types of HAI. 1. 32% - Urinary tract infections (UTI). Most Common HAI 2. 22% - Surgical site infections (SSI) 3. 15% - Pneumonia 4. 14% - Bloodstream infections (bacteremia) List the most common Gram positive and Gram negative microbes responsible for HAI. Most common Gram POSITIVE microbes: o o o Staphylococcus aureus Coagulase negative staphylococci (CoNS, includes S. epidermidis) Enterococci sp. Most common Gram NEGATIVE microbes: o o o o E. coli Pseudomonas aeruginosa Enterobacter sp. Klebsiella pneumoniae Describe the importance of C. difficile with respect to HAI. o o o o Gram positive anaerobe, spore former, toxin producer Patients most at risk: o Hospitalized patients on antibiotics o Greater than 65 years old Antibiotics kill off normal flora allows C. difficile to grow uncontrollably, results in diarrhea and pseudomembranous colitis. Essential in the care of any patient with CDI o Good hand hygiene-- Soap and water, hand sanitizers are not sporicidal. o Contact isolation Describe the 3 factors relevant to HAI. 1. Antimicrobial use in hospitals and long term care facilities. o Microbes in health care settings are constantly coming into contact with disinfectants, antiseptics and antimicrobials => increasing antimicrobial resistance. 2. Failure of basic infection control. o Most common mode of transmission is via hands 3. Patients are immunocompromised. o Simply placing a urinary catheter or an IV catheter compromises the initial defense barriers providing potential pathogens an entryway. Discuss the CDC’s role in the monitoring and prevention of HAIs. o o The CDC maintains the National Healthcare Safety Network (NHSN) o Compiles monthly reports of nosocomial infections from over 3,000 participating U.S. hospitals. The CDC publishes guidelines for the prevention of healthcare associated infections #4: Environmental/Occupational Health Know the definitions of environmental health & occupational health Environmental health: o o o Environmental Health addresses all physical, chemical, biological factors external to a person, and all related factors impacting behaviors Focuses on anything that may impact health in: o Natural environment (outdoor)--Example: outdoor air quality o Artificial environment (indoor)--Example: asbestos Focuses on identification and control/prevention of environmental factors that can potentially affect health Occupational health: o o Occupational health protects safety, health, and welfare of people engaged in work or employment. May also protect family members, employers, & customers Goal is to create safe work environment; identify and control risks in workplace Know the different areas of concern for environmental health Air quality -- outdoor and indoor, tobacco smoke Food safety -- agriculture, transportation, processing, distribution Water safety -- recreational water illness prevention, safe drinking water Radiological health -- exposure to ionizing radiation Waste management -- solid waste management, wastewater treatment plants, hazardous materials management Toxic chemical exposure -- consumer products, housing, workplaces, air, water, soil Noise pollution Vector control Answer the questions in Case Study #1 What could be causing his symptoms? Exposure to toxic lead fumes/poisoning (organic lead). Where did he likely come into contact with the contaminant? At the automotive radiator repair shop he plays after school. Is anyone else at risk? The employer and employees (& their family members), and customers Compare and contrast the types of radiation discussed Ionizing radiation (can cause cancer) types: Alpha radiation o Large: has 2 neutrons and 2 protons, Blocked by paper, Very little hazard to a humans unless ingested Beta particle o Consists of an energetic electron, Can be stopped by metal Gamma ray o Made of photons, more penetrating, stopped by thick layer of lead Define the role of OSHA (Occupational Safety and Health Administration, part of US Dept. of Labor) Role of OSHA is to ensure safe and healthful working conditions for working men and women by setting and enforcing standards and by providing training, outreach, education and assistance Discuss hazard and risk assessment Hazard Assessment o Individual workplace hazards identified, assessed and controlled/eliminated as close to source (location of the hazard) as possible Risk assessment includes: o Identification of hazards o Identification of affected workers o Evaluation of the risk o Identification of control measures o Can be quantitative (by assigning #) or qualitative (description) Know the different types of workplace hazards Physical hazards o Noise/vibration, ionizing radiation, electricity, asphyxiation, cold/heat stress o Mechanical hazards (collisions, falls, equipment-related injury) Biological hazards o Blood-borne pathogens, air-borne pathogens Chemical hazards o Acids/bases, heavy metals, solvents, asbestos, fumes Psychosocial issues o Work-related stress, bullying, sexual harassment Describe the contents and purpose of a MSDS (Material Safety Data Sheet) A form that contains important information for a substance o Should include instructions for safe use and potential hazards (melting point, boiling point, flash point, toxicity, health effects, first aid, storage, disposal, spill-handling procedures) o Must be made available in workplace for all hazardous chemicals being used #5: Emerging Infectious Diseases Define terms used in epidemiology. Emerging Infectious Disease (EID): o An infectious disease that has newly appeared in a population or that has been known for some time but is rapidly increasing in incidence or geographic range. Etiology: o The cause Incidence: o # of new cases within a specified time period. Prevalence: o Total # of cases in a given time period. Morbidity: o The number of cases resulting in illness/poor health. Mortality: o The number of cases resulting in death. Endemic: o Present in a low but constant level in an area. (common cold, heart disease) Outbreak: o An occurrence of disease greater than would be expected in a particular time/place Epidemic: o A sudden outbreak that spreads throughout the area. More cases then predicted within population. (cholera epidemic in Haiti) Pandemic: o Epidemic that spreads throughout the world. (AIDS, H1N1 influenza) Describe the system used to account for reportable diseases. Physician/Clinical Laboratory reports to the Local Health Dept. => LHD reports to State Health Dept. => SHD reports to CDC Worldwide/Global: WHO keeps track of EID’s List any 4 of the 8 theories of how/why emerging infectious diseases still exist. 1. 2. 3. 4. 5. 6. 7. 8. Human encroachment into undeveloped areas (Jungles) Population growth Increased worldwide travel. Increased worldwide trade of imported foods, plants and animals. Immigration Inadequacy of public health hygiene systems (Sanitation) Overuse/misuse of antibiotics Evolution/mutations of microbes Describe the progression of the SARS outbreak and what contributed to it. Outbreaks of severe pneumonia in healthy individuals was first seen November 2002 in China, with no idea of what was causing the deadly pneumonia China did not report the disease to WHO until Feb. 2003. Several teams from the WHO and the CDC traveled to Asia to investigate First described on Feb. 26, 2003 -- Identified as a new and deadly disease by World Health Organization (WHO) physician Dr. Carlo Urbani (who subsequently died from SARS on March 29, 2003) Outbreak began in Guangdong Province, China. Then spread to Hong Kong. One person infected 16 people on one floor of hotel leading to international spread => PANDEMIC In just a few weeks, SARS had spread through air travel to at least three continents In the same amount of time, researchers collaborated to identify the virus, sequence its genome, and take steps toward rapid diagnosis Within 1 month = 3000 cases, 100 dead in 20 countries SARS was stopped by quarantine, cooperation and collaboration, travel restrictions (pts and healthcare staff were quarantined). At the end of the outbreak 8098 cases in 28 countries,774 deaths in total SARS info: Coronavirus, transmitted via respiratory aerosols. Symptoms: fever, cough, sore throat, difficulty breathing, diarrhea, lethargy, myalgia. #6: Medical Error Papers To Err is Human Define medical errors. The failure of a planned action to be completed as intended, or the use of a wrong plan to achieve an aim Know the types of medical errors and list examples of each. Discuss how medical errors occur and the strategies for improvement. Med errors are caused by faulty systems, processes, and conditions that lead people to make mistakes or fail to prevent them Strategies for improvement: o Establishing a national focus to create leadership, research, tools, and protocols to enhance the knowledge base about safety (AHRQ-agency for healthcare research & quality) o Identifying and learning from errors by developing a nationwide public mandatory reporting system, and by encouraging healthcare organizations & practitioners to develop and participate in voluntary reporting systems o Raising performance standards and expectations for improvements in safety through the actions of oversight organizations, professional groups, and group purchasers of health care o Implementing safety systems in healthcare organizations to ensure safe practices at the delivery level Five years after to err is human—what have we learned? Discuss the stakeholders involved in reducing medical errors. Federal Gov’t: $50 annually for pt safety research Veteran’s Health Admin: system-wide pt safety training/practice/research JCAHO: non-gov’t; improved accountability NQF: public-private partnership; generated standards for mandatory reporting CDC, Centers for Medicare & Medicaid Services, surgical organizations: program to reduce surgical complications Amer. College of Physicians: incorporated safety topics into their meetings/education/research Nat’l Pt Safety Foundation: increasing awareness Institute for Healthcare Improvement: helped hospitals redesign their systems for safety Leapfrog Group: purchasers & payers; Encouraged adoption of safer practices Physicians, nurses, therapists, pharmacists: most important stakeholders Describe the barriers to change that exist to the attempts to improve patient safety. Complexity – many specialties/professions; technology Commitment to individ/professional autonomy – challenge of learning a non-blaming systemsoriented approach to errors Fear – fear that information would undermine public trust, fear of loss of autonomy, fear of malpractice liability (which inhibits willingness to admit/discuss errors) Lack of leadership – at hospital and health plan level Paucity of measures Current reimbursement structure works against improving safety – insurance companies sometimes won’t pay for new/safer practices; Pt injury => more billing/$$$ Discuss the various agencies, organizations and their varied attempts at altering the healthcare arena for patient safety. Fed Gov’t (Dept. Health & Human Services): electronic medical records JCAHO: furthering the adoption of the NQF proven safe practices The Accreditation Council on Graduate Medical Education: practice-based learning and systembased practices in residency training schemes Hospitals/Health Systems: providing team training; providing full-disclosure of pt injuries; providing bonuses/incentives for safe care (pay for performance) Payers: disincentives; cease paying for preventable adverse effects (so hospital gets stuck with paying for their mistake) What are the repercussions of disclosing a medical error? Explain the effect that disclosing a medical error has on the physician-patient relationship and the likeliness of legal action Full disclosure has little effect on the likelihood that an injured pt will seek legal counsel Disclosing a med error can improve a pt’s confidence in the physician and lead to improved outcomes Explain the concept that disclosure is Preventive Medicine against future errors Proper disclosure includes an explanation regarding the nature of an error & the measures being taken to prevent similar occurences in the future List and discuss the desires of patients when a medical error occurs. Pts prefer a detailed disclosure, including: o What happened o Why it happened o The consequences o Strategies for preventing future errors #12: Clinical Epidemiology Know the definitions of epidemiology and other terms covered Epidemiology o Study of patterns of health and illness and associated factors at population level Refer to #5 EID for other terms Discuss causality and when this term could be used Causality = cause of disease outbreak Biostatistics used to identify probability of association between cause and disease outcome. However, statistical association (or correlation) does not always equal causation. In 1965 Austin Bradford Hill detailed criteria for assessing evidence of causation: o Strength Larger association is more likely causal effect o Consistency Stronger association when same findings observed by different people and different samples o Specificity Causation likely if very specific population with specific disease and no other likely explanation (More specificity = bigger probability of causal effect) o Temporality Effect happens after the cause (i.e., cancer after exposure to radiation) o Biological gradient Greater exposure causes greater incidence o Plausibility Plausible mechanism between cause and effect helpful o Coherence Between epidemiological and laboratory findings increases likelihood of effect o Experiment "Occasionally it is possible to appeal to experimental evidence" o Analogy The effect of similar factors may be considered Describe the types of studies used in clinical epidemiology Qualitative studies o Case studies Case series studies Qualitative study of one pt or small group of pts with similar disease Self-controlled case-series studies Compare pt exposure periods to periods when they are unexposed (Pts diagnosed with disease and followed; Follow-up time divided into exposed and unexposed periods and incidence of disease compared) Quantitative studies o Case-control studies A retrospective study that looks in pt’s past for possible exposures that may have been encountered Cases are pts diagnosed with disease; Controls are pts not diagnosed with disease. Cases and controls should be matched as closely as possible (age, sex, ethnicity) o Cohort studies Prospective studies that select participants based on exposure status Participants are at risk of, but do not have, disease at initiation of the study Cohort is then followed prospectively for development of disease (Ex: cohort of smokers and cohort of non-smokers followed over time to estimate incidence of lung cancer) Know the 10 steps of an outbreak investigation Step 1: Prepare for field work o Research disease, gather supplies/equipment o Consult all parties to determine your role Step 2: Establish existence of outbreak o Verify that suspected outbreak is real outbreak o Outbreak exists if observed # of cases > expected # o However, observed # of cases > expected # may not indicate outbreak due to changes in population, new diagnostic techniques Step 3: Verify the Diagnosis o Review clinical findings and lab results o If uncertain about lab tests, have specialist review/order secondary tests o Visit with pts, take detailed history for shared risk factors Step 4: Define and Identify Cases o Establish case definition--classify pts as having disease or not o Case definition usually includes 4 components: Clinical information Characteristics about pts affected Information about location or place (restricts definition) Time during which outbreak occurred o Cases defined as: Confirmed case – must have lab verification Probable case – typical symptoms, no lab confirmation Possible case - few typical symptoms o Identify and count cases Passive surveillance -- send out letter describing situation Active surveillance -- telephone or visit facilities to collect information Sometimes public health officials alert public o Regardless of disease, collect following data Identifying information -- name, address, phone #/ e-mail Demographic information -- age, sex, race, occupation Clinical information -- symptoms and date of onset Risk factor information -- exposure to food, water sources Data collected on questionnaire, line listing Step 5: Describe Data in Terms of Time, Place, Person o Descriptive epidemiology Shows what information is reliable and informative Provides comprehensive description of outbreak Epi curve – # of cases by date of onset Provides information on geographic extent “Spot map" where affected people live, work, may have been exposed Hospital clustering usually indicates focal source or person-to-person spread Scattering of cases throughout a facility more consistent with common source (dining hall) If size of population varies between areas affected, spot map can be misleading; use proportion of pts in each area (attack rate) Determine populations at risk Step 6: Develop Hypotheses o Should address source of agent, mode of transmission, possible exposures Step 7: Evaluate Hypotheses o Compare hypotheses with established facts o Use analytic epidemiology; tests hypotheses, used when cause unclear Cohort study: compare pts exposed to risk factor with unexposed pts Case-control study: compare pts with disease to pts without disease Step 8: Refine Hypotheses and Carry Out Additional Studies Step 9: Implementing Control and Prevention Measures o Should be done ASAP o Aimed at specific links in chain of infection, agent, source, reservoir o Control measures at transmission or exposure Step 10: Communicate Findings o Oral briefing for local health authorities o Written report Analyze an epidemiology curve and discuss its importance in an outbreak investigation Epi curve – # of cases by date of onset Tell where you are in course of epidemic; project its future course Estimate probable time period of exposure Shape determines pattern of epidemic, exposure time, incubation o Single source epidemic: steep up slope and gradual down slope; people exposed to same source over brief period o Continuous common source epidemic: has plateau instead of peak o Person-to-person spread: series of progressively taller peaks 1 incubation apart #13: Current Trends Identify the leading cause of death, for all age groups, in 2007. In 2007, heart disease was the leading cause of death followed by cancer. Identify the causes of mortality which have decreased for each specific age group: Children 1-14 years old: Unintentional injuries Persons 25-44 years of age: Cancer, HIV Persons 45-64 years of age: Cancer, Heart disease Persons greater than 65 years of age: Heart disease Identify the predominate age group in which smoking cigarettes has declined. Grades 9-12 or Ages 15-18 Determine the rates of childhood and adult obesity. In 2008: Almost 1 in 5 children (20%) over 5 years of age were obese; with rates increasing! About 1/3 of adults were obese, and about 2/3 were overweight or obese. Compare the rates of serum cholesterol and statin use among adults. The % of adults 45 years and over with high serum total cholesterol declined . The % of adults 45 years and over using statin drugs increased over 10 fold. Describe the delay in seeking medical care and the rates of health insurance coverage amongst the 3 groups: private, uninsured and Medicaid. The percentage of adults who delayed or did not receive medical care due to cost increased among persons with private insurance and the uninsured. The percentage of working-age adults with private health insurance decreased while the percentage who were uninsured increased. #14: PH Policy Agencies Know the purpose of the World Health Organization and its core functions International agency that coordinates and acts on global public health issues Core functions: o Provide leadership on global health matters o Shape health research agenda and stimulate generation and dissemination of valuable knowledge o Set norms and standards o Articulate evidence-based policy options o Providing technical support to countries o Monitoring and assess health trends Know the role of the Department of Health and Human Services and the responsibilities of the 11 operating divisions HHS is U.S. government’s agency for protecting health of all Americans; provides essential human services, especially for those who are least able to help themselves 11 operating divisions/responsibilities: o Admin for Children and Families: ACF is responsible for promoting economic and social well-being of families, children, individuals, communities o Admin on Aging: AoA is responsible for ensuring continuation of aging services at state, territory, local and tribal levels o Agency for Healthcare Research and Quality: AHRQ mission is to improve quality, safety, efficiency, and effectiveness of health care for all Americans o Agency for Toxic Substances and Disease Registry: ATSDR is responsible for regulating public health effect of hazardous substances in environment o Centers for Disease Control and Prevention: CDC is responsible for conducting and supporting public health activities in the U.S. o Centers for Medicare and Medicaid Services: CMS is responsible for administering Medicare, Medicaid, and Children's Health Insurance Program (CHIP) o Food and Drug Admin: FDA is responsible for protecting American people from unsafe or mislabeled food, drugs, and other medical products and to make sure consumers o o o o o have access to accurate, science-based information about the products they need and rely on every day Health Resources and Services Admin: HRSA is responsible for improving access to health care services for people who are uninsured, isolated, medically vulnerable Indian Health Service: IHS is responsible for providing federal health services to American Indians and Alaska Natives Nat’l Institutes of Health: “nation’s medical research agency” Substance Abuse and Mental Health Services Admin: SAMHSA focuses on reducing impact of substance abuse and mental illness on America's communities Occupational Safety and Health Admin (OSHA) Discuss the five strategic focus areas of the CDC 1. 2. 3. 4. 5. Support state and local health departments Improve global health Decrease leading causes of death Strengthen surveillance and epidemiology Reform health policies Discuss the role of OSHA OSHA mission: assure safe and healthful working conditions for working men and women by setting and enforcing standards and by providing training, outreach, education and assistance
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