SALADI VENKATA RAJAGOPAL
Professor & Head Department of Biotechnology GITAM
Institute of Science, GITAM University Visakhapatnam –
530 045
Phone: +91-891-2840460
e-mail: [email protected]; [email protected]
Research Interests
Bioactive compounds – screening, isolation and characterization of bioactive compounds from seaweeds,
marine actinomycetes and micro algae.
Enzyme technology – screening of microbes producing industrially useful enzymes and their isolation,
purification, characterization and production by various fermentation approaches.
Academic profile:
• Ph.D. “Studies on rat brain DNases”, Andhra University (1996)
• M. Phil. “A native and UV-irradiated specific DNase from rat brain”, University of Hyderabad (1985)
• M.Sc. Biochemistry, University of Hyderabad (1984)
• B.Sc., Andhra University (1982)
• UGC NET (1986), UGC/ CSIR (1989)
• PG. Diploma in computer application.
Professional experience: 22Years
Professor of Biotechnology (Dec 2008 –till to date)
GIS, GITAM University, Visakhapatnam, India
Associate Professor, Dept. of Biotechnology (Sep 2006 – Dec 2008)
GIS, GITAM University, Visakhapatnam, India
Assistant Professor, Dept. of Biotechnology (Aug 1998 – Sep 2006)
COE, GITAM, Visakhapatnam, India
Lecturer, Dept. of Biochemistry (Aug 1992 – Jul 1998)
Mrs. A.V.N. College, Visakhapatnam, India
Projects completed
Andhra Pradesh Council of Science and Technology (APCOST) project entitled “Screening and
isolation of Antibacterial compounds from seaweeds of Visakhapatnam Coast”. Lr. No.
16/APCOST/S&T – SPP/2003-04, dt.06/12/2003.
Projects Sanctioned
University Grants Commission, New Delhi (UGC-MRP), project entitled “Studies on immunomodulators
from seaweeds of Bay of Bengal at Visakhapatnam Coast” Lr. No. UGC F.No.42-228/2013 (SR) dated
22nd March 2013.
Member Ships in Scientific Bodies
1. Life Member Biotechnology Society of India
IDNO. – 401, Membership No. LM-292
2. Life Member Society of Biological Chemists
India Membership No. -1790
3. Life member Indian Immunology Society
IDNo. LM-370
Reviewer: Academic journals
1. Journal of medicinal plant research
2. African journal of Biotechnology
Administrative experience
1. Head, Department of Biotechnology, GIS, GITAM University, July, 2007 – till date.
2. Member academic council, GITAM University, September, 2007 – till date.
3. Chairman, BOS, Department of Biotechnology, GIS, GITAM University, 2007 – 2010,
2013 to till date.
4. Member, BOS Department of Biochemistry DNR College, Bhimavaram.
Publications
1. K. Deepika, Mahesh Kumar M. V. S., T. S. D. Radhika and S. V. Rajagopal (2016)
Studies on isolation, purification and structure elucidation of chemical constituents from
methanolic flower extract of Blepharis molluginifolia pers. and their biological activities
International Journal of Pharmaceutical sciences and Research, Vol. 7(12): 4893-4904
2. Ravi Kumar Gutti, Usha Gutti, Jashwant Komati and Aneesh Kotipalli, Rajagopal
Venkata Saladi, (2016); Medicinal plants for the treatment of platelet disorders,
International journal of conceptions of Management and Social sciences, vol.4, Issue.2,
pp:2357-2787.
3. Mahesh Kumar MVS, Rajagopal S.V. (2015) Antioxidant, Antimicrobial.,
Antiproliferative activities and in silico drug likeness prediction of purified MHH
compound, isolated from Millingtonia Hortensis Linn. International Journal of Pharmacy
and Pharmaceutical Sciences;7,251-257
4. Ravinder Kandi, Usha Gutti, Rajagopal Venkata Saladi, Ravi Kumar Gutti.(2015) MiR125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in
childhood acute megakaryoblastic leukemia, Hematology Oncology stem cell therapy,
8(2); 95-97
5. Mahesh Kumar MVS, VSSL Prasad Talluri and S.V.Rajagopal (2015) Purification and
characterization of Bioactive compound from the methanolic leaf extract of Millingtonia
Hortensis Linn. (2015), International journal of Pharma and Biosciences,6 (3); 348-358
6. M. Bhavana, VSSL Prasad Talluri, K.Sivakumar, P. Anil Kumar and S.V.Rajagopal
(2014) Antimicrobial and Antiproliferative Activities of Streptomyces Carpaticus
(MTCC-11062) Isolated from Marine Sediment of Visakha Patnam Sea Coast. Journal
of Pure and Applied Microbiology, 8(6):4681-4686.
7. S. Deepika and S. V. Rajagopal (2014).Evaluation of In Vitro Antioxidant Activity of Flowers
of Blepharis Molluginifolia. Int Journal of Pharm sci and research. Vol. 5(6): 2225-2229.
8. M. Bhavana, Vssl Prasad Talluri, K. Siva Kumar, S. V. Rajagopal. (2014) Optimization
Of Culture Conditions Of Streptomyces Carpaticus (Mtcc-11062) For The Production
Of Antimicrobial Compound. International Journal Of Pharmacy And Pharmaceutical
Sciences 6( 8): 281-285.
9. S. Deepika and S. V. Rajagopal 2014 (2014) Evaluation Of Phytochemical And Bioactive
Screening Of Blepharis Molluginifolia Flower Extracts Int J Pharm Bio Sci 5 (3) : 204
– 211.
10. VSSL Prasad Talluri, M. Bhavana, MVS Mahesh Kumar, S. V. Rajagopal. (2014) Lasparaginase: An ultimate anti-neoplastic enzyme. International Letters of Natural
Sciences. 10: 68-80.
11. VSSL Prasad Talluri, Bhavana M, Siva Kumar K, Anil Kumar P, Rajagopal SV (2014)
Myroides gitamensis Sp.Nov., L-Asparaginase Producing Bacteria Isolated from
Slaughter House Soil Sample in Visakhapatnam, India. J Microb Biochem Technol 6:
144-147. doi:10.4172/1948-5948.1000135 (ISI/Scopus)
12. Mahesh Kumar MVS, VSSL Prasad Talluri and S V Rajagopal (2014) Studies on
Phytochemical Constituents, Antimicrobial and Antioxidant activities of Some
Medicinal Plants of North Coastal Andhra Pradesh. Int J Pharm Bio Sci 5(3): 26 –37.
13. M. Bhavana, VSSL. Prasad, K. Sivakumar and SV. Rajagopal (2013) Screening and
Isolation of Antagonistic Actinobacteria from marine sediments of Visakhapatnam Sea
Coast. International journal of pharmaceutical, chemical and biological sciences, 3(3):
767-770.
14. VSSL Prasad Talluri, M Bhavana and S V Rajagopal. (2013) Isolation and screening of
L– asparaginase producing bacteria from visakhapatnam soil samples. International
journal of pharmaceutical, chemical and biological sciences, IJPCBS, 3(4): 1121-1125.
15. K.Susheela Branham, V. Murali Krishna, S.V. Raja Gopal and
A.J.Solomon Raju
(2012)
Study
to
evaluate
the
efficacy
of
clinical
response in assessing the chemosensitivity in correlation with caspase-3
amplification in advanced
Allied Sciences 1(2):1-10
breast
cancer.
Journal
of
Basic
Medical
and
16. DPN Ramakrishna, N Gopi Reddy, SV Raja Gopal (2012)Solid state fermentation for
the production of alkaline protease by Bacillus Subtilis KHS-1 (MTCC No-10110) using
different agro-industrial residues. International journal of Pharmacy and Pharmaceutical
Research.vol 4 (1); Pp:512-517
17. N.G.Reddy, D.P.N. Ramakrishna, S.V.Rajagopal (2011) A Morphological,
Physiological and Biochemical studies of Marine Streptomyces rochei (MTCC 10109)
showing antagonistic activity against selective human pathogenic microorganisms. Asian
Journal of Biological Science 4(1):1-14.
18. K. Siva Kumar and S V Rajagopal, (2011) Radical scavenging Activity of
Green Algal Species. Journal of Pharmacy Research Vol. 4. Issue 3.723725.
19. Samuel LA1, Venkata Raman B*, Pardha Saradhi M, Narashimha Rao B, Naga Vamsi
Krishna A, Rajagopal SV and Radhakrishnan TM (2011) Isolation and purification of
antibacterial protein from Euphatorium odoratum: A seasonal folk medicinal plant.
Journal of Pharmacy Research. 4(12), 4641-4645.
20. N. Gopi Reddy, D.P.N. Ramakrishna and S.V.Rajagopal (2011). Mutation
Induced Enhanced Production of Bioactive Metabolites by a Mutant Strain of Marine
Streptomyces
rochei
(Isolate
No.10)
Asian
Journal
of
Chemistry; Vol.23.No.9, 4205-4208.
21. N Gopi Redy, D.P.N. Ramakrishna and S.V. Rajagopal (2011) Optimization of culture
conditions of Streptomyces rochei (MTCC 10109) for the roduction of
antimicrobial metabolites Egyptian Journal of Biology, Vol.13.pp 21-29.
22. N Gopi Reddy, DPN Ramakrishna, SV Rajagopal (2011). Effect of different cultural,
physiological and nutritional parameters on Streptomyces rochei (MTCC 10109)
antimicrobial metabolites production. Association of Pharmaceutical Innovators.
vol.4.pp.2675-2678
23. N.G.Reddy, D.P.N. Ramakrishna, S.V.Rajagopal.(2011) A Morphological,
Physiological and Biochemical studies of Marine Streptomyces rochei (MTCC 10109)
showing antagonistic activity against selective human pathogenic microorganisms. Asian
Journal of Biological Sciences Volume 4 number 1 pp.1-14.
24. D.P.N. Ramakrishna, N.G.Reddy, S.V.Rajagopal.(2010) Optimization of an Alkaline
protease production from Bacillus subtilis (KHS-1) isolated from Slaughter house soil
sample (MTCC 10110). International journal of Biotechnology and bioengineering
research.Volume 1 number 1 pp.19-28.
25. D.P.N. Ramakrishna, N.G.Reddy, S.V.Rajagopal.(2010) Purification and Properties of
an extracellular Alkaline protease produced by Bacillus subtilis (MTCC 10110).
International journal of Biotechnology and Biochemistry.Volume 6 number 4 pp.493504.
26. N.Gopi Reddy, D.P.N Ramakrishna, Sharmistha Patnaik, K.Siva Kumar, M.Rama
Rao, S.V.Rajagopal.(2010) Screening and Isolation of Marine Actinomycetes from
Visakhaptanam sea coast showing antagonistic activity against selective human
pathogenic microorganisms. Asian journal of chemistry. Volume 22 number 10, 77457752.
27. D.P.N Ramakrishna, N.Gopi Reddy, Sharmistha Patnaik, K.Siva Kumar,
S.V.Rajagopal.(2010) Isolation and characterization of an alkaline protease producing
Bacillus subtilis (KHS-1) from slaughterhouse soil samples. Asian journal of chemistry.
Volume 22 number 5, 4061-4068.
28. S.V. Rajagopal, A. Prasada Rao, B.V.Raman, M. Rama Rao, A. Uma Sankar, A.
Sunitha Kumari, K. Siva Kumar.(2008).Biochemical and antibacterial studies on green
algae of visakhapatnam coast. Journal of pure and Applied Microbiology. Vol.02, No.02,
573-578.
29. M.Rama rao, I.Bhaskar Reddy, S.V.Rajagopal, A.D.Naveen Kumar, A.Ramesh,
T.Kartika.(2008) Effect of Holoptelea intigrifolia bark on radical scavenging and 5’
lipoxygenase activities. Biomedical and Pharmacology Journal Vol. 1(2), 349-358.
30. M.Rama rao, G.Satyanvani, A.D.Naveen Kumar, S.V.Rajagopal.(2008) Comparative
evaluation of the antioxidant potential of selected Indian medicinal plants (Rasayanas).
Biomedical and Pharmacology Journal Vol. 1(2), 375-382.
31. N.Kiran Kumar, K.Siva Kumar, B.V.Raman, M.Rama rao, I.Bhaskar Reddy and
S.V Rajagopal (2008) Antibacterial Activity of Lippia citriodora A Folklore
plant.Journal of Pure and Applied Microbiology Vol. 2(1), 249-252.
32. S.V Rajagopal, B.V.Raman, I.Bhaskar Reddy, M. Rama rao, and K.Siva Kumar,
(2008). Antioxidants and Free Radical Scavenging activity of Brown Algae of
Visakhapatnam coast. Asian Journal of Chemistry. Vol.20, No. 7,5347-5352.
33. M. Rama Rao I. Bhaskar Reddy, S.V. Rajagopal, D. Bhaskar and T. Ramana, (2008). A
Comparative Study of Antimicrobial Activity of Curcuma amada and Alpinia galanga
of Zingiberaceae Family. Asian Journal of Chemistry. Vol.20, No. 7, 5293-5300.
34. S.V Rajagopal, K.Siva Kumar, A.Uma sankar, M.Rama rao, Sunita Kumari.(2007)
Production and Characterization of Cellulase by Stretobacillus Species-APS 8, Journal
of Pure and Applied Microbiology Vol. 1(2), 231-236.
35. S.V Rajagopal, B.V.Raman, I.Bhaskar Reddy,
M. Rama rao, and K.Siva
Kumar(2007) Antioxidants and Free Radical Scavenging activity of Red Algae
ofVisakhapatnam coast. BiosciencesBiotechnologResearchAsiaVol.4,No.2,645- 650.
36. M. Rama rao, I.Bhaskar Reddy, T. Ramana, S.V Rajagopal, B.V.Raman, D.S. Pallavi
and D.Hyma (2007) Radical Scavenging and Antioxidants activity of Ethylacetate
fraction of Plectranthus aromaticus leaves. Biosciences, Biotechnology Research Asia
Vol 4, No.2, p. 581-588.
37. M. Rama rao, I.Bhaskar Reddy, S.V Rajagopal, B.V.Raman, and T.Ramana (2007)
Evaluation of Antioxidant properties of Sweet Basal “Asian Journal of Biotechnology,
Microbiology and Environmental Sciences” Vol.9. No.(4) 811– 818.
38. M. Rama rao, I.Bhaskar Reddy, S.V Rajagopal, B.V.Raman, T.Ramana and D.Bhaskar
Rao (2007) In vitro inhibition of lipid peroxidation and antimicrobial activity of
Sapindus trifoliatus pericarp Journal of Phytological Research Vol. 20, No.2,215-218.
39. Venkata Raman.B, D.N.Rao, I.Bhaskar Reddy, S.V. Rajagopal and Radhakrishnan,T.M
(2006) Selective induction of protective humoral immune response by aqueous extract of
Spirulina platensis against food allergens – “Journal Flora and Fauna” vol.12, No.2
40. Rajagopal. S.V, Radhakrishnan. T. M. and Venkata Raman. B (2006) Studies on
biochemical and antibacterial activities of Red algae of Visakhapatnam seacoast. “Asian
Journal of Biotechnology, Microbiology and Environmental Sciences”
Vol. 8 (1) 115
– 118.
41. I.Bhaskar Reddy, K.P.J. Hemalatha, S.V Rajagopal, B.V.Raman, M. Rama rao, D.
Sivaprasad and T.G.Reddi (2006), An eliminative procedure for β- Mercaptoethanol
interposing in thiol-proteases assay by lowrys method. Proc A.P. Akademi of Sciences,
Vol: 10 (3 & 4) :197-205.
42. Venkata Raman. B., Radhakrishnan. T.M. and Rajagopal, S.V (2005): Antibacterial
and immunomodulatory studies on selected brown algal species of Visakhapatnam
Seacoast. Indian J of Microbiology, Vol. 45, No.3, 245-249.
43. S.V. Rajagopal & K. Subba Rao. (1992) “Purification and properties of a
Deoxyribonuclease (Acid DNase) form rat brain”, Biochemical archives, Vol 8, pp. 135142, (U.S.A)
CHAPTER IN A BOOK:
Sanjeev Raghuwanshi, Hanuma Kumar Karnati, Shilpa Sarvothaman, Usha Gutti,
Raja Gopal Venkata Saladi, Prathibha Reddy Tummala and Ravi Kumar Gutti
Chapter 10 microRNAs: Key Players in Hematopoiesis.
Title of the book: Advances in experimental medicine and biology (2015); Springer
International Publishing, ISBN 978-3-319-22379-7, vol.887, pp:171-211
Seminars/ conferences:
1. B.Chandra Sekhar, M.Rama Rao ,G.Suresh , S.V.Rajagopal. “Effect of pharmaceutical
industrial Effluent on the Germinating Allium cepa and Brassica nigra”. International
Conference on Sustainable Environmental Sanitation and Water Resources During New
Millenium.26th March-2008.Organized by Department of Environmental Studies, GITAM
University, Visakhapatnam Bharathi theertha – USA and India Development Coalition of
America –USA.
2. M.Rama Rao, I.Bhaskar Reddy, S.V.Rajagopal and T.Ramana. ‘DNA Damage Prtectily
activity of Holoptelea Integrifolia’ National Symposium on Society for free Radical
Research-India. February 11-12, 2008. organized by Department of Biochemistry, All India
Institute of Medical Sciences, New Delhi.
3. G.P.R Reddy, Krishna Chardra, M, L.A. Samuel, Murali Mohan.N., Venkata Raman, B and
S.V.Rajagopal. “Isolation of α-Amylase producing streptobacillus strain from
Visakhapatnam soil samples” in a national seminar on Environmental Biotechnology
organized by Department of Botany, Microbiology and Biotechnology, JKC College,
Guntur during 21 to 22 January, 2006.
4. L.A. Samuel, M. Sudhakar, Umamaheswari, M., S.V.Rajagopal, Bhaskar Reddy, I, Murali
Mohan.N., Krishna Chardra, M. Pandu Ranga Reddy, G and Venkata Raman, B.
“Antibacterial studies on some folklore medicinal plants of North Coastal Andhra Pradesh”
in a national seminar on Environmental Biotechnology organized by Department of
Botany, Microbiology and Biotechnology, JKC College, Guntur during 21 to 22 January,
2006.
5. Murali Mohan.N., L.A. Samuel, S.V.Rajagopal, Krishna Chardra, M. Pandu Ranga Reddy,
G and Venkata Raman, B. “Biochemical studies on α- Amylase inhibitors derived from
Indian medicinal herbs as potential Antidiabetic agents” in a national seminar on
Environmental Biotechnology organized by Department of Botany, Microbiology and
Biotechnology, JKC College, Guntur during 21 to 22 January, 2006.
6. M.Rama Rao, I.Bhaskar Reddy, S.V.Rajagopal, B.V.Raman and T.Ramana. ‘In Vitro
Inhibition of Lipid Peroxidation and Antimicrobial Activity of Sapindus Trifoliatus
Pericarp. National Symposium on Recent Trends in Biochemistry 22 nd December2006.Organized by Department of Biochemistry, T.J.P.S.College, Guntur.
7. Venkata Raman, B; L.A.Samuel; M, Uma Maheswari; S.V. Rajagopal and T.M.Radhakrishnan.
Antibacterial studies on some medicinal plants of North Castal Andhra Pradesh in 46 th ANNUAL
CONFERENCE of ‘Association of Microbiologists of India’ organized in Dept. of Microbiology,
Osmania University, Hyderabad during 8th – 10th December 2005.
8. S.V.Rajagopal and T.M.Radhakrishnan. Presented a paper entitled ‘Studies on Brown Algae of
Visakhapatnam coast’ in a National Symposium on 21st Century Perspectives in Plant Sciences held
at Andhra University, Visakhapatnam during July 29th to 31st, 2001.
9. S.V.Rajagopal, K.Subba Rao and T. Govardana Reddi, “A Native and UV – irradiated
DNA specific Deoxyribonuclease from rat brain” National seminar on trends in
Biotechnology in the 21st century – perspectives in bioactive molecules held at College of
engineering, Gandhi Institute of Technology and Management, Visakhapatnam during 12 –
14 February 2001.
10. S.V.Rajagopal and T. Govardana Reddi, “ Isolation and characterization of marine bacteria
from Visakhapatnam coast” National seminar on trends in Biotechnology in the 21st century –
perspectives in bioactive molecules held at College of engineering, Gandhi Institute of Technology
and Management, Visakhapatnam during 12 – 14 February 2001.
11. S.V. Rajagopal, P. Srinivas, G.B.R. Sastrulu, and T. Govardana Reddi, “Studies on
Halophiles” 66th Annual general body meeting of Society of Biological Chemists (India),
held at, Visakhapatnam, 1997.
12. P. Srinivas, G.B.R. Sastrulu, S.V. Rajagopal and T. Govardana Reddi, “Microbial
degradation in agricultural soils” 66th Annual general body meeting of Society of Biological
Chemists (India), held at, Visakhapatnam, 1997
13. G.B.R. Sastrulu, P. Srinivas, S.V. Rajagopal and T. Govardana Reddi, “Bacterial
degradation of organophosphorous pesticides” 66th Annual general body meeting of Society
of Biological Chemists (India), held at, Visakhapatnam, 1997.
14. S.V. Rajagopal and T. Govardana Reddi. “Purification and characterization of a single
stranded and Apurinic DNase from rat brain” XXIII Annual Conference of Indian
Immunology Society, held at Visakhapatnam, December 1996.
15. S.V. Rajagopal and T. Govardana Reddi “Studies on halobacteria)” 61st annual general body
meeting of Society of Biological Chemists (India), held at Hyderabad, 1992.
Refresher courses attended:
1.
Participated in the awareness Programme on “Nuclear Energy” sponsored by Nuclear Power
Corporation, Bombay, organized by Center for Nuclear Techniques, Andhra University,
Visakhapatnam form 21-04-1994 to 22-04-1994
2.
Attended UGC, refreshers course on “Perspectives in Biochemistry” conducted by Indian
Institute of Science (IISc.), Bangalore from May 6th to 27th, 2002
3.
Attended Refresher course on “Plant Biotechnology” sponsored by A.P Netherlands
Biotechnology Programme, organized by the Biotechnology Division, Andhra University,
Visakhapatnam from 03-05-2003 to 24-05-2003.
4.
Attended workshop on “Patent Awareness” sponsored by PFC, Technology Information,
Forecasting & Assessment Council (TIFAC) and Dept. of Science & Technology (DST), Govt.
of India, organized by Gandhi Institute of Technology and Management (GITAM), Visakhapatnam
on 30th July 2005
Seminars/Workshops Organized:
1. Impact of Nanobiotechnology on healthcare, agriculture and environment INHAE-2013 organized by
GITAM University, on December 17 & 18, 2013 - Convenor.
2. Workshop on Plant Molecular Biology organized by GITAM University, on 6th December-2013
2. TRendys organized by GITAM University, on December 14 & 15, 2012 - Convenor.
3. International Conference on Biotechnology in Pharma & Food Industries organized by GITAM
University, on 29th & 30th July, 2011 – Co-convenor
4. Science Academies Lecture Workshop on Protein Engineering and its Applications organized by Indian
science academies, on 20th – 21st January, 2011 as Co – convenor.
5. National Seminar on impact of Biotechnology on herbal formulations organized by GITAM University,
on 28th July, 2010 as Convenor.
6. National Seminar on Emerging Trends in Cell and Nano Biotechnology funded by DST, DBT-CSIR,
ICMR, on 11th – 12th 2009 as Convenor.
7. Recent Advances in Genomics and Proteomics organized by Departments of Biotechnology,
Biochemistry and Microbiology, GITAM University, on 14th February, 2009, as Convenor.