Ian S. Haworth, Ph.D.
Date of Birth:
Citizenship:
Work Address:
Department of Pharmacology &
Pharmaceutical Sciences
University of Southern California
1985 Zonal Avenue
Los Angeles, CA 90089-9121
8th June, 1962, Blackpool, England
United Kingdom
(U.S. Permanent Resident)
tel. (323) 442-3310
fax. (323) 442-1390
e-mail: [email protected]
https://ihlab.hsc.usc.edu
Education / Professional Experience
1992-
Department of Pharmacology & Pharmaceutical Sciences, University of Southern
California
Associate Professor of Pharmaceutical Sciences, 1998Assistant Professor of Pharmaceutical Sciences, 1992-1998
1989-1992 Physical Chemistry Laboratory, Oxford University, Oxford, England
Postdoctoral Research funded by the National Foundation for Cancer Research
'Computer Modelling of the Structure and Dynamics of DNA'
advisor: Dr. W. Graham Richards.
1986-1989 Department of Chemistry, University of Liverpool, Liverpool, England
Ph.D. in Physical Organic Chemistry.
S.E.R.C. / C.A.S.E. award with I.C.I. (Advanced Materials)
'N.M.R. and Computer Modelling of Polymer Structure'
advisor: Prof. Raymond J. Abraham.
1982-1985 Department of Chemistry, Manchester Polytechnic, Manchester, England.
GRSC / B.Sc. 2.1 (Chemistry).
Peer-Reviewed Publications
(91) Ratnatilaka Na Bhuket P, El-Magboub A, Haworth IS, Rojsitthisak P. Enhancement of
curcumin bioavailability via the prodrug approach: challenges and prospects. Eur J Drug Metab
Pharmacokinet 2016 Sep 28. [Epub ahead of print]
(90) Tangprasertchai NS, Zhang X, Ding Y, Tham K, Langen R, Rohs R, Haworth IS, Qin PZ.
Integrated spin-labeling/computational-modeling approaches for mapping global structures of
nucleic acids. Methods Enzymol 2015;564:427-453.
(89) Ambroso MR, Haworth IS, Langen R. Structural characterization of membrane curving
proteins; sample preparation and SDSL, EPR, and computational refinement. Methods Enzymol
2015;564:259-288.
(88) Beasley KN, Sutch BT, Hatmal MM, Langen R, Qin PZ, Haworth IS. Computer modeling
of spin labels: NASNOX, PRONOX and ALLNOX. Methods Enzymol 2015;563:569-593.
(87) Law MJ, Lee DS, Lee CS, Anglim PP, Haworth IS, Laird-Offringa IA. The role of the Cterminal helix of U1A protein in the interaction with U1hpII RNA. Nucleic Acids Res
2013;41:7092-7100.
(86) Romero RM, Rojsitthisak P, Haworth IS. Electrophoretic mobility of duplex DNA
crosslinked by mechlorethamine at a cytosine-cytosine mismatch pair. Electrophoresis
2013;34:917-924.
(85) Li Y, Hatmal MM, Langen R, Haworth IS. Idealized models of protofilaments of human
islet amyloid polypeptide. J Chem Inf Model 2012;52:2983-2991.
(84) Popova A, Hatmal MM, Frushicheva M, Price EA, Qin PZ, Haworth IS. Nitroxide sensing
of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular
dynamics simulations. J Phys Chem B 2012;116:6387-6396.
(83) Zhang X, Tsung CS, Zowa GZ, Hatmal MM, Haworth IS, Qin PZ. Global structure of a
three-way junction in a phi29 packaging RNA dimer determined using site-directed spin
labeling. J Am Chem Soc 2012;134:2644-2652.
(82) Bedrood S, Li Y, Isas JM, Hegde BG, Baxa U, Haworth IS, Langen R. Fibril structure of
human islet amyloid polypeptide. J Biol Chem 2012;287:5235-41.
(81) Hatmal MM, Li Y, Hegde BG, Hegde PB, Jao CC, Langen R, Haworth IS. Computer
modeling of nitroxide spin labels on proteins. Biopolymers 2012;97:35-44.
(80) Li Y, Sutch BT, Bui HH, Gallaher TK, Haworth IS. Modeling of the water network at
protein-RNA interfaces. J Chem Inf Model 2011;51:1347-1352.
(79) Rojsitthisak P, Jongaroonngamsang N, Romero RM, Haworth IS. HPLC-UV, MALDITOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosinecytosine mismatch pair. PLoS ONE 2011;6:e20745.
(78) Xu L, Li Y, Haworth IS, Davies DL. Functional role of the intracellular loop linking
transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1. J Membr Biol
2010;238:43-49.
(77) Jao CC, Hegde BG, Gallop JL, Hegde PB, McMahon HT, Haworth IS, R.Langen. Roles of
amphipathic helices and the BAR domain of endophilin in membrane curvature generation. J
Biol Chem 2010;285:20164-20170.
(76) Sutch BT, Chambers EJ, Bayramyan MZ, Gallaher TK, Haworth IS. Similarity of proteinRNA interfaces based on motif analysis. J Chem Inf Model 2009;49:2139-2146.
(75) Xu L, Haworth IS, Kulkarni AA, Bolger MB, Davies DL. Mutagenesis and cysteine
scanning of transmembrane 10 of the human dipeptide transporter. Pharm Res 2009;26:23582366.
(74) Tsai AG, Engelhart AE, Hatmal MM, Houston SI, Hud NV, Haworth IS, Lieber MR.
Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites.
J Biol Chem 2009;284:7157-7164.
(73) Jao CC, Hegde BG, Chen J, Haworth IS, Langen R. Structure of membrane-bound alphasynuclein from site-directed spin labeling and computational refinement. Proc Natl Acad Sci
USA 2008;105:19666-19671.
(72) Zheng Y, Chow AHL, Haworth IS. Molecular modeling of flavonoid--cyclodextrin
complexes. Lett Drug Des Disc 2008;5:512-520.
(71) K.Li, L.Xu, Kulkarni AA, D.I.Perkins, Haworth IS, Davies DL. Ethanol inhibits functional
activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes.
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Alcohol Clin. Exp. Res 2008;32:777-784.
(70) Dowd C, Sutch BT, Haworth IS, Eritja R, Marquez VE, Yang AS. Incorporation of
zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a templatecoding nucleobase. Nucleosid Nucleotid Nucleic Acids 2008;27:131-145.
(69) Qin PZ, Haworth IS, Cai Q, Kusnetzow AK, Grant GPG, Price EA, Sowa GZ, Popova A,
Herreros B, He H. Measuring nanometer distances in nucleic acids using a sequence-independent
nitroxide probe. Nature Protocols 2007;2:2354-2365.
(68) Price EA, Sutch BT, Cai Q, Qin PZ, Haworth IS. Computation of nitroxide-nitroxide
distances in spin-labeled DNA duplexes. Biopolymers 2007;87:40-50.
(67) Cai Q, Kusnetzow AK, Hideg K, Price EA, Haworth IS, Qin PZ. Nanometer distance
measurements in RNA using site-directed spin labeling. Biophys J 2007;93:2110-2117.
(66) Schiewe AJ, Haworth IS. Structure-based prediction of MHC-peptide association: algorithm
comparison and application to cancer vaccine design. J Mol Graph Model 2007;26:667-675.
(65) Links JLS, Kulkarni AA, Davies DL, Lee VHL, Haworth IS. Cysteine scanning of
transmembrane domain three of the human dipeptide transporter: implications for substrate
transport. J Drug Target 2007;15:218-25.
(64) Bui HH, Schiewe AJ, Haworth IS. WATGEN: an algorithm for modeling water networks at
protein-protein interfaces. J Comp Chem 2007;28:2241-2251.
(63) Kulkarni AA, Davies DL, Links JS, Patel LN, Lee VHL, Haworth IS. A charge pair
interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane
segment 8 of the human dipeptide transporter hPepT1. Pharm Res 2007;24:66-72.
(62) Cai Q, Kusnetzow AL, Hubbell WL, Haworth IS, Gacho GPC, van Eps N, Hideg K,
Chambers EJ, Qin PZ. Site-directed spin labeling measurements of nanometer distances in
nucleic acids using a sequence-independent nitroxide probe. Nucleic Acids Res 2006;34:47224730.
(61) Law MJ,.Linde ME, Chambers EJ, Oubridge C, Katsamba PS, Nillson L, Haworth IS,
Laird-Offringa IA. The role of positively charged amino acids and electrostatic interactions in
the complex of U1A protein and U1 hairpin II RNA. Nucleic Acids Res 2006;34:275-285.
(60) Bui HH, Schiewe AJ, von Grafenstein H, Haworth IS. Structural prediction of peptides
binding to mhc class i molecules. Proteins 2006;63:43-52.
(59) Law MJ, Chambers EJ, Katsamba PS, Haworth IS, Laird-Offringa IA. Kinetic analysis of
the role of the tyrosine 13, phenylalanine 56, and glutamine 54 network in the U1A/U1 hairpin II
interaction. Nucleic Acids Res 2005;33:2917-2928.
(58) Raghavan SC, Chastain P, Lee JS, Houston S, Hegde BG, R.Langen, Hsieh CL, Haworth IS,
Lieber MR. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the
t(14;18) translocation. J Biol Chem 2005;280:22749-22760.
(57) Zheng Y, Haworth IS, Zuo Z, Chow MSS, Chow AHL. Physicochemical and structural
characterization of quercetin-β-cyclodextrin complexes. J Pharm Sci 2005;94:1079-1089.
(56) Yu K, Roy D, Bayramyan M, Haworth IS, Lieber MR. Fine-structural analysis of
activation-induced deaminase accessibility to class switch region R-loops. Mol Cell Biol
2005;25:1730-1736.
(55) Raghavan SC, Houston S, Hegde BG, Langen R, Haworth IS, Lieber MR. Stability and
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strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. J Biol Chem
2004;279:46213-46225.
(54) Kulkarni AA, Haworth IS, Uchiyama T, Lee VHL. Analysis of transmembrane segment 7 of
the dipeptide transporter hPepT1 by cysteine scanning mutagenesis. J Biol Chem
2003;278:51833-51840.
(53) Kulkarni AA, Haworth IS, Lee VHL. Transmembrane segment 5 of the dipeptide
transporter hPepT1 is an amphipathic helix that forms part of the substrate translocation
pathway. Biochem Biophys Res Commun 2003;21:111-125.
(52) Chambers EJ, Price EA, Bayramyan MZ, Haworth IS. Computation of DNA backbone
conformations. J Biomol Struct Dyn 2003;306:177-185.
(51) Katsamba PS, Bayramyan MZ, Haworth IS, Myszka DG, Laird-Offringa IA. Complex role
of the 2-3 loop in the interaction of U1A with U1 hairpin II RNA. J Biol Chem
2002;277:33267-33274.
(50) Rojsitthisak P, Romero RM, Haworth IS. Extrahelical cytosine bases in DNA Duplexes
containing d[GCC]nd[GCC]n repeats: detection by a mechlorethamine crosslinking reaction.
Nucleic Acids Res 2001;29:4716-4723.
(49) Romero RM, Rojsitthisak P, Haworth IS. DNA Interstrand crosslink formation by
mechlorethamine at a cytosine-cytosine mismatch pair: kinetics and sequence dependence. Arch
Biochem Biophys 2001;386:143-153.
(48) Rodger A, K.J.Sanders, M.J.Hannon, I.Meistermann, A.Parkinson, D.S.Vidler, Haworth IS.
DNA structure control by polycationic species: polyamine, cobalt ammines, and di-metallo
transition metal chelates. Chirality, 2000, 12:221-236.
(47) Meng WS, von Grafenstein H and Haworth IS. Water dynamics at the HLA-A2 / peptide
interface. Int Immunol 2000;12:949-957.
(46) Meng WS, Bui HH, Haworth IS. Exploiting the peptide-MHC water interface in the
computer-aided design of non-natural peptides that bind to the class I MHC molecule HLA-A2.
Mol Sim 2000;24:215-229.
(45) Gurlo T, Meng WS, Bui HH, Haworth IS, Von Grafenstein H. Experimental evidence for
the presence of a water network at the peptide-MHC interface. Immunol Lett 1999;70:139-141.
(44) Lee VHL, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu
SK, Hamm-Alvarez S, Okamoto CT. Biopharmaceutics of transmucosal peptide and protein drug
administration: role of transport mechanisms with a focus on the involvement of PepT1. J Contr
Rel 1999;62:129-140.
(43) Coggan DZM, Haworth IS, Bates PJ, Robinson A, Rodger A. DNA binding of ruthenium
tris(1,10-phenanthroline): evidence for the dependence of binding mode on metal complex
concentration. Inorg Chem 1999;38:4486-4497.
(42) Shamma T, Haworth IS. Spermine inhibition of the 2,5-diaziridinyl-1,4-benzoquinone
(DZQ) crosslinking reaction with DNA duplexes containing poly(purine)poly(pyrimidine)
tracts. Nucleic Acids Res 1999;27:2602-2609.
(41) Romero RM, Mitas M, Haworth IS. Anomalous crosslinking by mechlorethamine of DNA
duplexes containing C-C mismatch pairs. Biochemistry 1999;38:3641-3648.
(40) Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez SF,
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Okamoto CT, Basu SK, Wu S, Lee VHL. Structure, function and molecular modeling
approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci 1998;87:12861291.
(39) Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez SF, von Grafenstein H,
Shen WC, Kim KK, Bolger MB, Haworth IS, Ann DK, Lee VHL. Molecular identification of a
role for tyrosine 167 in the function of the human intestinal proton-coupled dipeptide transporter
(hPepT1). Biochem Biophys Res Commun 1998;250:103-107.
(38) Basu SK, Haworth IS, Bolger MB, Lee VHL. Proton-driven dipeptide uptake in primary
cultured rabbit conjunctival epithelial cells. Invest Ophth Vis Sci 1998;39:12:2365-2373.
(37) Meng WS, Bhavaraju A, von Grafenstein H, Haworth IS. Modeling of the non-obese
diabetic mouse class II MHC molecule I-Ag7. Protein Peptide Lett 1998;5:75-82.
(36) Blagbrough IS, Taylor S, Carpenter ML, Novoselskiy V, Shamma T, Haworth IS.
Asymmetric intercalation of acridine-9-carbonyl-N1-spermine at homopurine sites of duplex
DNA. J Chem Soc Chem Commun 1998:929-930.
(35) Meng WS, von Grafenstein H, Haworth IS. A model of water structure inside the HLA-A2
peptide binding groove. Int Immunol 1997;9:1339-1346.
(34) Yu A, Romero RM, Barron MD, Dill J, Christy M, Gold B, Gray DM, Haworth IS, Mitas
M. At physiological pH d(CCG)15 forms a hairpin containing protonated cytosines and a
distorted helix. Biochemistry 1997;36:3687-3699.
(33) Meng WS, Gallaher TK, Von Grafenstein H, Haworth IS. Sequence dependent
conformational motion of a peptide in the HLA-A2 binding groove. Protein Peptide Lett
1996;3:51-58.
(32) Yuki M, Grukhin V, Lee CS, Haworth IS. Spermine binding to GC-Rich DNA:
experimental and theoretical studies. Arch Biochem Biophys 1996;325:39-46.
(31) Mitas M, Yu A, Dill J, Haworth IS. The trinucleotide DNA repeat sequence d(CGG)15
forms a heat-stable hairpin containing Gsyn.Ganti base pairs. Biochemistry 1995;34:12803-12811.
(30) Yu A, Dill J, Wirth SS, Huang G, Lee VH, Haworth IS, Mitas M. The trinucleotide repeat
sequence d(GTC)15 adopts a hairpin conformation. Nucleic Acids Res 1995;23:2706-2714.
(29) Daude N, Gallaher TK, Zeschnigk M, Starzinski-Powitz A, Petry KG, Haworth IS,
Reichardt JKV. Molecular cloning, characterization and mapping of a full-length cDNA
encoding human UDP-galactose 4' epimerase. Biochem Mol Med 1995;56:1-7.
(28) Rodger A, Taylor S, Adlam G, Blagbrough IS, Haworth IS. Multiple DNA binding modes
of anthracene-9-carbonyl-N1-spermine. Bioorg Med Chem 1995;3:861-872.
(27) Mitas M, Yu A, Dill J, Kamp TJ, Chambers EJ, Haworth IS. Hairpin properties of singlestranded DNA containing a GC-rich triplet repeat: (CTG)15. Nucleic Acids Res 1995;23:10501059.
(26) Remias MG, Lee CS, Haworth IS. Molecular dynamics simulations of chlorambucil / DNA
adducts. A structural basis for the 5'-GNC interstrand DNA crosslink formed by nitrogen
mustards. J Biomol Struct Dyn 1995;12:911-936.
(25) Adlam G, Blagbrough IS, Taylor S, Latham HC, Haworth IS, Rodger A. Multiple binding
modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption
and molecular modelling compared with those of spermidine and spermine. Bioorg Med Chem
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Lett 1994;4:2435-2440.
(24) Chambers EJ, Haworth IS. A stable cis-azobenzene in aqueous solution. J Chem Soc Chem.
Commun 1994:1631-1632.
(23) Gallaher TK, Haworth IS, Shih JC. Determination of the agonist binding site of the 5-HT2
receptor using molecular mechanics and molecular dynamics. Med Chem Res 1993;3:344-356.
(22) Jabs EW, Muller U, Li X, Ma L, Luo W, Haworth IS, Klisak I, Sparkes R, Warman ML,
Mulliken JB, Snead ML, Maxson R. A mutation in the homeodomain of the human MSX2 Gene
in a family affected with autosomal-dominant craniosynastosis. Cell 1993;75;443-450.
(21) Haworth IS, Lee CS, Yuki M, Gibson NW. Molecular dynamics simulations provide a
structural basis for the experimentally observed nucleotide preferences of DNA interstrand crosslinks induced by aziridinylbenzoquinones. Biochemistry 1993;32:12857-12863.
(20) Hutchin T, Haworth IS, Higashi K, Fischel-Ghodsian N, Stoneking M, Saha N, Cortopassi
G. A molecular basis for human hypersensitivity to aminoglycoside antibiotics. Nucleic Acids
Res 1993;21:4174-4179.
(19) Yuki M, Haworth IS. The DNA complexes of aziridinylbenzoquinones. A molecular
mechanics study. Anti-Cancer Drug Design 1993;8:269-287.
(18) S.R.Sanghani, Elcock AH, Haworth IS. SUBCUR: visualisation of structural variance in
DNA duplexes. J Mol Graph 1993;11:211-213.
(17) Haworth IS, Rodger A, Richards WG. A molecular dynamics simulation of a polyamineinduced conformational change of DNA. A possible mechanism for the B to Z transition. J
Biomol Struct Dyn 1992;10:195-211.
(16) Haworth IS, Elcock AH, Rodger A, Richards WG. A binding mode of -[tris(1,10phenanthroline) ruthenium(II)]2+ exhibiting preference for purine-3',5'-pyrimidine sites of DNA.
J Biomol Struct Dyn 1991;9:553-569.
(15) Haworth IS, Elcock AH, Freeman J, Rodger A, Richards WG. Sequence selective binding to
the DNA major groove. Tris(1,10-phenanthroline) metal complexes binding to poly(dG-dC) and
poly(dA-dT). J Biomol Struct Dyn 1991;9:23-44.
(14) Haworth IS, Rodger A, Richards WG. A molecular mechanics study of spermine
complexation to DNA: a new model for spermine-poly(dG-dC) binding. Proc Roy Soc Lond B
1991;244:107-116.
(13) Haworth IS, Burt C, Gago F, Reynolds CA, Richards WG. A prototype bioreductive DNA
groove binding ligand. Anti-Cancer Drug Design 1991;6:59-70.
(12) Morley SD, Abraham RJ, Haworth IS, Jackson DE, Saunders MR, Vinter JG. COSMIC90 an improved molecular mechanics treatment of hydrocarbons and conjugated systems. J ComputAided Mol Design 1991;5:475-504.
(11) Abraham RJ, Grant GH, Haworth IS, Smith PE. Charge calculations in molecular
mechanics. Atomic charges from classical calculations. J Comput-Aided Mol Design 1991;5:2139.
(10) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether
copolymers. Sulphonated aryl ether ketones. Polymer 1991;32:1414-1419.
(9) Abraham RJ, Haworth IS. Molecular modelling of poly(aryl ether ketones). Chain packing in
crystalline PEK and PEEK. Polymer 1991;32:121-126.
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(8) Abraham RJ, Haworth IS. Molecular modelling of poly(aryl ether ketones). Aryl..aryl
interactions in crystal structures. J Comput-Aided Mol Design 1990;4:283-294.
(7) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether
copolymers. Aryl ether ketone copolymers in acid solution. Polymer 1990;31:728-735.
(6) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether
copolymers. Materials containing sulphonated aryl rings. Polymer 1990;31:126-129.
(5) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether
copolymers. The effect of biphenyl functionality. Polymer 1989;30:1169-1972.
(4) Abraham RJ, Haworth IS. A modification to the COSMIC parameterisation using ab initioconstrained potential functions. J Comput-Aided Mol Design 1988;2:125-135.
(3) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether
copolymers. Ether sulphone / ether ether sulphones and ether sulphone / ether ketone in
deuterated DMSO. Polymer 1988;29:1110-1117.
(2) Abraham RJ, Haworth IS. A lanthanide induced shift (LIS) study of aryl sulphones using a
novel lanthanide-sulphone complexation model. Magn Reson Chem 1988;26:252-259.
(1) Abraham RJ, Haworth IS. A theoretical and lanthanide induced shift (LIS) study of
benzophenone and 3,4'-dichlorobenzophenone. J Chem Soc Perkin Trans 2 1988:1429-1437.
Submitted Manuscripts
(1) Coricello A, Perri F, Luna M, Ferrario A, El-Magboub A, Haworth IS, Aiello A, Williams T,
Nguyen C, Lien EJ, Gomer CJ, Adams JD. Sesquiterpene-based cyclooxygenase 2
pharmacology and enhancement of photodynamic therapy. Future Med Chem 2016, submitted.
Reviews, Book Chapters and Other Publications
(10) El-Magboub A, Rojsitthisak P, Muangnoi C, Wichitnithad W, Romero RM, Haworth IS.
Biological targets and pharmacology of curcumin. In: Curcumin: Synthesis, Emerging Role in
Pain Management and Health Implications, Ed. Pouliquen DL. Nova Science Publishers
2014;103-133.
(9) Rojsitthisak P, Wichitnithad W, Muangnoi C, El-Magboub A, Romero RM, Haworth IS.
Design, synthesis and biological activities of curcumin prodrugs. In: Curcumin: Synthesis,
Emerging Role in Pain Management and Health Implications, Ed. Pouliquen DL. Nova Science
Publishers 2014;135-175.
(8) Jongaroonngamsang N, Romero RM, Haworth IS, Rojsitthisak P. HPLC-UV determination
of a mechlorethamine crosslink in a DNA duplex containing a cytosine-cytosine mismatch pair. J
Health Res 2010;24:155-160.
(7) Lertsutthiwong P, Haworth IS, Rojsitthisak P. Alginate: A promising polysaccharide for
delivery of essential oils. In: Carbohydrate Polymers: Development, Properties and Applications.
Eds. Ito R, Matsuo Y. Nova Science Publishers, Hauppauge, NY, 2010.
(6) Sutch BT, Haworth IS. Development of a protein-nucleic acid interaction database: potential
for use in drug design against any protein target. Proceedings of the 9th APRU Doctoral Students
Conference. Far Eastern National University, Vladivostok, Russia, 2008.
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(5) Haworth IS. Computational drug delivery. Adv Drug Deliv Rev 2006;58:1271-1273.
(4) Schiewe AJ, Haworth IS. Avian influenza vaccine development: computational epitope
identification through structural prediction of MHC-peptide association. Proceedings of the 7th
APRU Doctoral Students Conference: Inventing the Future: Trends, Perspectives and Enterprise
from the Pacific Rim, National University of Singapore, 2006.
(3) Haworth IS. Monograph on protein solubility. In Chemistry: Foundations and Applications,
Ed. Lagowski J, Macmillan Reference USA, 2004.
(2) Haworth IS. Monograph on ibuprofen. In Chemistry: Foundations and Applications, Ed.
Lagowski J, Macmillan Reference USA, 2004.
(1) Romero RM, Cheng HY, Mitas M, Haworth IS. Molecular dynamics simulations of DNA
molecules containing d(GCC)n..d(GCC)n fragments and C-C mismatch pairs. In Structure,
Motion, Interaction and Expression of Biological Macromolecules, Volume 2. Proceedings of the
10th Conversation in Biomolecular Stereodynamics, Albany, N.Y. Eds. Sarma RH, Sarma MH,
Adenine Press, 1998.
Invited Lectures
(63) 'Computational Molecular Docking'. University of the Philippines, Manila, Philippines,
December 2016.
(62) 'Algorithms for Computer Modeling: EPR-based Protein Structure and Solvation of ProteinLigand Interfaces'. USC Biophysics Program, Los Angeles, CA, September 2016.
(61) ‘Computational Biochemistry: Protein Structure, Spin Labels and Solvation'. Universiti
Teknologi MARA (UiTM), Puncak Alam, Malaysia, November 2015.
(60) ‘Computer Modeling in Drug Discovery and Target Development'. 4th International
Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science (IPNaCS), Melaka,
Malaysia, November 2015.
(59) ‘Solubility in Drug Formulation and Solvation in Drug-Target Interactions’. 31st
International Annual Meeting in Pharmaceutical Sciences, Bangkok, Thailand, January 2015.
(58) ‘The Human Dipeptide Transporter (hPEPT1): Mutagenesis Data and Structure’. Vincent
H.L. Lee Symposium, University of Colorado, Denver, CO, June 2012.
(57) ‘Lipid-Bound Proteins and Amyloid Fibrils: Structures from EPR and Computer Modeling’.
Chulalongkorn University, Bangkok, Thailand, August 2011.
(56) ‘Structure Determination using EPR and Computer Modeling’. UCSF, San Francisco, CA,
April 2009.
(55) ‘Structure Determination using EPR and Computer Modeling’. R.J. Abraham Symposium,
Manchester, UK, October 2008.
(54) ‘Nucleic Acids in Silico: Therapeutic Agents & Biochemical Targets’. Simulations Plus,
Lancaster, CA, January 2008.
(53) ‘Drugs Based on Peptides and Nucleotides’. Chulalongkorn University, Bangkok, Thailand,
August 2007.
(52) ‘Structural Basis of Peptide-MHC Association: Peptide Vaccine Design’. USC Norris
Cancer Center Grand Rounds, Los Angeles, CA, July 2007.
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(51) ‘Computer Modeling in Drug Discovery and Delivery’. MannKind Corporation, Valencia,
CA, March 2007.
(50) ‘Computer Modeling in Drug Discovery and Delivery’. Dept. of Chemistry & Biochemistry,
California State University, Los Angeles, Los Angeles, CA, January 2007.
(49) ‘Computer Modeling of Biomolecular Structure’. USC Department of Biochemistry &
Molecular Biology Retreat, Newport Beach, CA, October 2006.
(48) ‘Computational Approaches to Prediction of pKa and logD’. AAPS Annual Meeting,
Nashville, TN, November 2005.
(47) ‘Computer Modeling, Drug Development and Nanotechnology’. Mahidol University,
Bangkok, Thailand, August 2005.
(46) ‘DNA Condensation: Modeling, Nanotechnology and Gene Delivery’. Nanotechnology and
Drug Discovery Meeting, Chulalongkorn University, Bangkok, Thailand, August 2005.
(45) ‘Computational Molecular Docking and Molecular Bioinformatics’. Nanotechnology and
Drug Discovery Meeting, Chulalongkorn University, Bangkok, Thailand, August 2005.
(44) ‘Peptide-Based Drug Discovery’. Nanotechnology and Drug Discovery Meeting,
Chulalongkorn University, Bangkok, Thailand, August 2005.
(43) ‘Nucleic Acid-Based Drug Discovery’. Nanotechnology and Drug Discovery Meeting,
Chulalongkorn University, Bangkok, Thailand, August 2005.
(42) ‘Computer Modeling of Transporter Proteins: Molecular Informatics and Translocation
Pathways’. Controlled Release Society, Miami Beach, FL, June 2005.
(41) ‘Computational Docking of Biological Macromolecules: Protein-RNA and Protein-Peptide
Interfaces’. Pharmaceutical Sciences World Congress 2004, Kyoto, Japan, June 2004.
(40) ‘Promiscuous Proteins and Slippery DNA: Computer Modeling of Biomolecular Structure’,
Phi Sigma Biological Honors Society, University of Southern California, Los Angeles, CA,
February 2004.
(39) ‘Computer Modeling of Biomolecular Interfaces: Protein Interactions with Peptides and
Nucleic Acids’. USC Department of Biochemistry & Molecular Biology Retreat, Laguna Beach,
CA, November 2003.
(38) ‘Chemistry of the Mustard-DNA Crosslink: From C-C DNA to eE-DNA’. Cerus
Corporation, Concord, CA, May 2003.
(37) ‘Computer Prediction of Peptide-MHC Association and Peptide Immunogenicity’. Division
of Biostatistics, University of Southern California, Los Angeles, CA, February 2003.
(36) ‘Protein-Peptide Interactions: Binding and Transport’. Molecular Biopharmaceutics 2003,
Honolulu, HI, January 2003.
(35) ‘Genomics, Computation and New Drug Targets’. AAPS Moving Targets Meeting, Los
Angeles, CA, August, 2002.
(34) ‘Small Molecule - DNA Association: Chemistry and Computer Modelling’. Dept. of
Chemistry, University of Canterbury, Christchurch, New Zealand, July 2002.
(33) ‘Triplet Repeat DNA: Structure and Slippage’. Dept. of Pharmaceutical Sciences, National
University of Singapore, Singapore, July 2002.
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(32) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and
Delivery’. Dept. of Pharmaceutical Sciences, National University of Singapore, Singapore, July
2002.
(31) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and
Delivery’. Dept. of Pharmaceutical Sciences, Chinese University of Hong Kong, Hong Kong,
July 2002.
(30) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and
Delivery’. Sankyo Pharmaceutical Co., Tokyo, Japan, July 2002.
(29) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and
Delivery’. Dept. of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan, July 2002.
(28) ‘Promiscuous Proteins and Slippery DNA: Computer Modelling of Biomolecular Structure’.
Dept. of Plant & Microbial Sciences, University of Canterbury, Christchurch, New Zealand, June
2002.
(27) ‘Triplet Repeat DNA: Structure, Slippage and Crosslinking Reactions’. University of
Auckland Cancer Centre, Auckland, New Zealand, June 2002.
(26) ‘Triplet Repeat DNA: Structure and Slippage’. Dept. of Chemistry and Biochemistry,
California State University Fullerton, Fullerton, CA, March 2002.
(25) ‘Conformations of Fragile X-Associated Triplet Repeat DNA Containing C-C Mismatch
Pairs’. American Chemical Society Meeting, San Diego, CA, April 2001.
(24) ‘Triplet Repeat DNA: Conformation and Slippage’. Dept. of Chemistry and Biochemistry,
California State University Northridge, Northridge, CA, March 2001.
(23) ‘Pharmacogenomics and Drug Development’. Eino Nelson Conference, Captiva Island, FL,
January 2001.
(22) ‘Modeling of Transmembrane and Cell Surface Proteins’. University of the Saarland,
Saarbrucken, Germany, March 2000.
(21) ‘Computer Modeling and Drug Design’. USC-Japan Symposium, Pasadena, CA, July 1999.
(20) ‘DNA Interstrand Crosslinking: New Chemistry and Biophysics’. USC-Norris Cancer
Center Grand Rounds, University of Southern California, Los Angeles, CA, July 1999.
(19) ‘MHC-Peptide Interactions: Specificity, Promiscuity and the Role of Water’. Virtual
Lecture, MolSim99 Electronic Conference, April 1999.
(18) ‘DNA Crosslinking Reactions: Revisiting the Old, Understanding the New’. Welsh School
of Pharmacy, University of Cardiff, Cardiff, U.K., March 1999.
(17) ‘MHC-Peptide Interactions: Specificity, Promiscuity and the Role of Water’. School of
Pharmacy and Pharmacology, University of Bath, Bath, U.K., March 1999.
(16) ‘DNA Crosslinking Reactions: Revisiting the Old, Understanding the New’. Dept. of
Chemistry, Reading University, Reading, U.K., March 1999.
(15) ‘MHC-Peptide Interactions: Specificity, Promiscuity and the Role of Water’. Dept. of
Biological Sciences, University of Essex, Colchester, U.K., March 1999.
(14) ‘Peptide Inhibitors of TGF-beta Based on Computer Models of TGF-beta Receptor
Structure’. AAPS Western Regional Meeting, San Francisco, CA, April 1998.
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(13) ‘Mechlorethamine Crosslinking of d(CCG)n Trinucleotide Repeat DNA’.10th Conversation
in Biomolecular Stereodynamics, Albany, NY, June 1997.
(12) ‘Computer Modeling of Proteins and DNA : Peptide-MHC and DNA-DZQ.’. Dept. of
Biochemistry. & Molecular Biology, Oklahoma State University, Stillwater, OK, November
1995.
(11) ‘Aziridnylquinone-DNA Interactions Studied by Computer Simulation’. AAPS Annual
Meeting, Miami Beach, FL, November 1995.
(10) ‘Computer Modeling of Repeat Sequence DNA: d(GC)n.d(GC)n and d(CCG)n.d(GGC)n’.
Children’s Hospital of Los Angeles, Los Angeles, CA, October 1995.
(9) ‘Computer Modeling of the Anthracene-9-carbonyl-N1-spermine Complex with DNA’.
AAPS Annual Meeting, San Diego, CA, November 1994.
(8) ‘Computer Modeling of DNA Alkylation Reactions’. Dept. of Chemistry & Biochemistry,
California State University, Los Angeles, Los Angeles, CA, November 1993.
(7) ‘Computer Modeling of the Chlorambucil / DNA Interaction’. AAPS Annual Meeting,
Orlando, FL, November 1993.
(6) ‘Computer Modeling of DNA’. Dept. of Biochemistry & Molecular Biology, University of
Southern California, Los Angeles, CA, May 1993.
(5) ‘Dynamics of DNA Structure and the B to Z Transition’. Program for Mathematics and
Molecular Biology, Santa Fe, NM, November 1992.
(4) ‘Modeling Ligand Binding in the DNA Major Groove’. Royal Society of Chemistry Meeting,
‘Progress in Computer Modeling of Biomolecules’, University of Nottingham, U.K., March
1992.
(3) ‘Polyamine / DNA Interactions’. Molecular Graphics Society Meeting, Merck U.K., Harlow,
U.K., December 1991.
(2) ‘The Development of Potential Functions in the COSMIC Force Field’. University of
Nottingham, U.K., September 1991.
(1) ‘N.M.R. and Computational Studies of Polymer Structure’. Dept. of Organic Chemistry,
University of Liverpool, U.K., February 1989.
Abstracts
80 published abstracts (available on request)
Professional Activities
Visiting Professor, University of the Phillippines, Manila, Philippines, December 2016.
Reviewer, AACP New Investigator Awards, October 2016.
Program Review, University of Arizona School of Pharmacy, October 2016.
Program Review, Western University of Health Sciences, MS Pharmaceutical Sciences,
September 2016.
Coordinator: Seventh USC-Taiwan Summer Course in Drug Discovery, July 2016.
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Organizer: USC School of Pharmacy Retreat, May 2016.
Visiting Professor, Chulalongkorn University, Bangkok, Thailand, January, 2015.
Judge, California Science Fair, Los Angeles, CA, May, 2014.
Coordinator: Fourth USC-Taiwan Summer Course in Drug Discovery, July 2013.
Judge, California Science Fair, Los Angeles, CA, May, 2013.
Editorial Advisory Board: Thai Journal of Pharmaceutical Sciences, 2012Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2012.
Coordinator: Third USC-Taiwan Summer Course in Drug Discovery, July 2012.
Editorial Advisory Board: Computational Molecular Biosciences, 2011Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2011.
Coordinator: Second USC-Taiwan Summer Course in Drug Discovery, July 2011.
Judge, Intel ISEF Science Fair, Los Angeles, CA, May, 2011.
Judge, California Science Fair, Los Angeles, CA, May, 2011.
Editorial Advisory Board: Analytical Biochemistry, 2011Coordinator: First USC-Taiwan Summer Course in Drug Discovery, July 2010
Editorial Advisory Board: World Journal of Biological Chemistry, 2009Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2009.
Reviewer, Louisiana Board of Regents Research Program, December, 2007-2009.
Editorial Advisory Board: Current Proteomics, 2007-2014
Co-Organizer, 3rd Interdisciplinary Program in Drug Discovery (IPIDD) Meeting, Burbank, CA,
September, 2007.
Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2007.
Reviewer, Louisiana Board of Regents Support Fund for Research & Development, January,
2007.
Reviewer, U.S. Civilian R&D Foundation BRHE Fellowships, September, 2006.
Co-Organizer, 2nd Interdisciplinary Program in Drug Discovery (IPIDD) Meeting, La Canada,
CA, June, 2006.
Theme Editor, “Computer Modeling in Drug Delivery”, Advanced Drug Delivery Reviews,
2006.
Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2005.
Symposium Chair, “Bioinformatics and Computer Modeling in Drug Targeting and Delivery”,
Controlled Release Society, Miami Beach, June, 2005.
Co-Organizer, 1st Interdisciplinary Program in Drug Discovery (IPIDD) Meeting, La Canada,
CA, June, 2005.
External Thesis Reviewer, Liu Jining, National University of Singapore, October, 2004.
Reviewer, AAAS Cobre Program, June, 2004.
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External Thesis Reviewer, Poon Thong Yuen, National University of Singapore, March, 2004.
Member of Programming Committee and Abstract Reviewer, AAPS National Biotech Meeting,
Boston, May, 2004.
Symposium Co-Organizer and Moderator; “Nucleic Acids, Drug Targets and Gene Therapy”,
AAPS Annual Meeting, Salt Lake City, October, 2003.
Symposium Co-Organizer and Moderator; “Proteomics and Chemo-Informatics in Drug
Discovery and Development”, AAPS Annual Meeting, Salt Lake City, October, 2003.
Member of Annual Meeting Planning Committee, AAPS Annual Meeting, Salt Lake City,
October, 2003.
Chair, Abstract Review Committee, Drug Design & Discovery Section, AAPS Annual Meeting,
Salt Lake City, October, 2003.
Vice-Chair, Drug Design & Discovery (DDD) Section: American Association of Pharmaceutical
Scientists (AAPS), 2003.
Abstract Reviewer, AAPS National Biotech Meeting, Boston, June, 2003.
Chair, Abstract Review Committee, Drug Design & Discovery Section, AAPS Annual Meeting,
Toronto, November, 2002.
Visiting Erskine Fellowship Professor, University of Canterbury, Christchurch, New Zealand,
May-July, 2002.
Abstract Reviewer, AAPS National Biotech Meeting, San Diego, June, 2002.
Reviewer, South Carolina EPSCoR Program, March, 2002.
Vice-Chair Elect, Drug Design & Discovery (DDD) Section: AAPS, 2002.
Abstract Reviewer for Medicinal and Natural Products Section, AAPS Annual Meeting, Denver,
October, 2001.
Co-Chair of Medicinal and Natural Products Podium Session, AAPS Annual Meeting,
Indianapolis, November, 2000.
Abstract Reviewer for Medicinal and Natural Products Section, AAPS Annual Meeting,
Indianapolis, November, 2000.
External Thesis Reviewer, Cairo University, Giza, Egypt, April, 2000.
Editorial Advisory Board: AAPS PharmSci, 1999 - 2008.
Abstract Reviewer for Medicinal and Natural Products Section, AAPS Annual Meeting, New
Orleans, November, 1999.
Editorial Advisory Board: Pharmaceutical Research, 1998 - current.
Co-Chair of Medicinal and Natural Products Podium Session, ‘Polyamines, Peptides and Other
Natural Products’, AAPS Annual Meeting, San Francisco, November, 1998.
Program Co-Organizer and Abstract Reviewer for Medicinal and Natural Products Section,
AAPS Annual Meeting, San Francisco, November, 1998.
Chair of Medicinal and Natural Products Podium Session, ‘Drug Design, Synthesis and
Mechanism of Action’, AAPS Annual Meeting, Boston, November, 1997.
Program Co-Organizer and Abstract Reviewer for Medicinal and Natural Products Section,
- 13 -
AAPS Annual Meeting, Boston, November, 1997.
Co-Chair of Trinucleotide Repeat DNA Colloquium, 10th Conversation in Biomolecular
Stereodynamics, Albany, NY, June, 1997.
Chair of Medicinal and Natural Products Podium Session, AAPS Annual Meeting, Seattle,
November, 1996.
Computer Programs and Websites
(12) ALLNOX. Flexible labeling of biomolecules (2015-). Beasley K, Sutch BT, Haworth IS;
publication (88). <https://ihlab.hsc.usc.edu/allnox/>
(11) MFIBRIL. Building of fibril structure (2012-). Li Y, Haworth IS; publication (85).
<http://chemsoft.hsc.usc.edu:8080/MFIBRIL/>
(10) SIMA (Similarity by Identity and Motif Analysis). Calculation of similarity of protein-RNA
complexes (2009-). Sutch BT, Li Y, Bayramyan MZ, Haworth IS; v.1.0; publication (76).
(9) PRONOX (PROtein structure with NitrOXide Labels). Calculation of nitroxide spin label
distributions in proteins (2008-). M.Hatmal, Li Y, Haworth IS; publication (81).
<https://ihlab.hsc.usc.edu/pronox/ >
(8) NASNOX (Nucleic Acids: Structure with NitrOXide Labels). Calculation of nitroxide spin
label distributions in DNA and RNA (2007-). Price EA, M.Hatmal, Haworth IS; v1.0 ,
publication (62); v.1.1, publication (67); v.1.1-W (NASNOX-W; Web version), publication (69).
<http://pzqin.usc.edu/NASNOX/>
(7) WATGEN. Solvation of protein-protein interfaces (2006-). Li Y, Sutch BT, Bui HH, Schiewe
AJ, Haworth IS; v.1.0, publication (64); v.1.1 (includes RNA and DNA), publication (80).
<https://ihlab.hsc.usc.edu/watgen/ >
(6) PEPSSI (PEptide-MHC Prediction of Structure through Solvated Interfaces). A PC-based
program for computation of MHC-peptide structure (2006). Bui HH, Schiewe AJ, Haworth IS;
v.1.0, publication (60).
(5) NASDAC (Nucleic Acids: Structure, Dynamics and Conformation). A program for building
of DNA structure (2001). Price EA, Chambers EJ, Bayramyan MZ, Haworth IS; v.1.0, abstract
(40); v.1.01, publication (52); v.1.1, Price EA Ph.D. Thesis, 2008.
<https://ihlab.hsc.usc.edu/nasdac/ >
(4) PHARMLAB: Teaching of structure/function relationships in drug degradation and
illustration of chemical kinetics (1995). Bolger MB, Haworth IS; educational publication (2).
(3) NEMESIS: PC-based molecular modeling (Oxford Molecular, Oxford, U.K.) (1990)
Contributions to force field development and implementation of energy functions; publication
(12).
(2) CHARGE3: A package for rapid computation of atomic charges based on molecular dipoles
(1990). Abraham RJ, B.D.Hudson. P.E.Smith. G.H.Grant, Haworth IS. (University of Liverpool,
U.K.); publication (11).
(1) LIRAS4: Computation of NMR chemical shifts induced by lanthanide shift reagents (1987).
Abraham RJ, Haworth IS (University of Liverpool, U.K.); publication (2).
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Education Publications
(9) El Magboub A, Haworth IS, Sutch BT, Romero RM. Evaluation of in-class and online
discussion meetings in a biopharmaceutics problem-based learning class. Curr Pharm Teach
Learn 2016;8:811-820
(8) Chatfield AJ, Romero RM, Haworth IS. Information intervention in the pharmaceutical
sciences. Med Ref Serv Quart 2012;31:188-201.
(7) Sutch BT, Romero RM, Neamati N, Haworth IS. Integrated teaching of structure-based drug
design and biopharmaceutics: A computer-based approach. J Chem Ed 2012;89:45-51.
(6) Romero RM, Eriksen SP, Haworth IS. Quantitative assessment of assisted problem-based
learning in a pharmaceutics course. Am J Pharm Ed 2010;74:Article 66.
(5) Romero RM, Eriksen SP, Haworth IS. A decade of teaching pharmaceutics using case studies
and problem-based learning. Am J Pharm Ed 2004;68:Article 31.
(4) Haworth IS, A. Garrill. Assessment of verbal communication in science education: a
comparison of small and large classes. Biochem Mol Biol Ed 2003;31:24-27.
(3) Haworth IS, Eriksen SP, Chmait SH, Matsuda LS, McMillan PA, King EA, LetourneauWagner J, Shapiro K. A problem-based learning, case study approach to pharmaceutics: faculty
and student perspectives. Am J Pharm Ed 1998;62:398-405.
(2) Bolger MB, Haworth IS. PharmLabTM: A computer program for the calculation and
visualization of drug degradation pH rate profiles. Am J Pharm Ed 1997;61:281-287.
(1) Haworth IS, Bolger MB, Eriksen SP. The use of computer-based case studies in a problemsolving curriculum. Am J Pharm Ed 1997;61:97-102.
Education Presentations
(19) Lilly Conference. 'Problem-Based and Team-Based Learning Strategies in a
Biopharmaceutics Course', Anaheim, CA, February 2017.
(18) University of the Philippines Manila. 'Learner-Centered, Case Study-Based Teaching in
Pharmaceutical Sciences'. Manila, Philippines, December 2016.
(17) University of the Philippines Manila. 'Building Skills of Faculty Members for Pharm.D.
Programs'. Manila, Philippines, December 2016.
(16) Turning Technologies User Conference. 'Reinforcement of Key Concepts in
Biopharmaceutics using Clickers and Turning Point Polling'. Las Vegas, NV, October 2016.
(15) USC Libraries Strategic Planning Panel Discussion. 'Health Sciences Faculty Perspectives'.
Los Angeles, CA, April 2016.
(14) UC Riverside School of Medicine. 'Automated Curriculum Mapping'. Riverside, CA,
January 2016.
(13) Cyberjaya University College of Medical Sciences. ‘The Pharm.D. Program at USC:
Curriculum Development and Problem-Based Learning’. Cyberjaya, Malaysia, November 2015.
(12) Universiti Teknologi MARA (UiTM). ‘The Pharm.D. Program at USC: Curriculum
Development and Problem-Based Learning’. Puncak Alam, Malaysia, November 2015.
(11) USC Center for Exccellence in Teaching Panel Discussion. 'Roles for Teaching Assistants
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in the Sciences'. Los Angeles, CA, October 2015.
(10) National Nanotechnology Center, ‘Graduate Education’. Bangkok, Thailand, August 2012.
(9) Chulalongkorn University Faculty of Pharmaceutical Sciences, ‘Problem-Based Learning in
Pharmacy Education’. Bangkok, Thailand, August 2012.
(8) USC MS Global Health Taiwan Visitors Program, ‘Pharmacy Education’. Los Angeles, CA,
June 2012.
(7) USC School of Pharmacy Board of Councilors Annual Meeting. ‘Genomics, Proteomics and
Bioinformatics: Implications for Pharmaceutical Research and Education’. Los Angeles, CA,
October 2002.
(6) Talk and Panelist at the NIH Extramural Associates Meeting on Sponsored Research at
Minority Institutions. ‘Partnerships and Collaborations at the University of Southern California’.
Los Angeles, CA, May 1997.
(5) District 7&8 NABP / AACP Annual Meeting. ‘The Case Study Method Applied to a Basic
Science Course in the Pharm.D. Curriculum’. Sacramento, CA, November 1996.
(4) Poster at AACP Annual Meeting. 'The Use of Computers in a Problem-Solving Curriculum.
Case Studies in the Kinetics of Drug Degradation and in the Flocculation of Dispersed Systems',
Reno, NV, July 1996.
(3) Poster at AACP Annual Meeting. 'PharmLab: A Simulation Program for the Estimation of
Drug Degradation pH Rate Profiles. Use in a Case Study-Based Problem-Solving Curriculum.
Bolger MB, Haworth IS. Reno, NV, July 1996.
(2) Submission to the AACP ‘Innovations in Teaching’ Competition. Received Honorable
Mention. AACP Annual Meeting, Reno, NV, July 1996.
(1) Poster presentation by Avi Bhavaraju, California State High School Science Fair, in
conjunction with the USC-Bravo High School partnership (STAR). A.Bhavaraju, Meng WS and
Haworth IS. ‘Computer modeling of peptide interactions with class II MHC molecules’, May
1996.
Research Students
Ph.D.
1992-1997
1993-1998
1995-1999
1997-2002
1997-2003
1998-2004
1999-2008
2000-2004
2001-2006
2002-2006
2004-2010
2007-2011
2009-2013
2012-
Masayuki Yuki: ‘Polyamine-DNA Complexes: Experiment and Theory’
Wilson Meng: ‘Simulation and Binding Studies of Peptide / MHC Complexes’
Rebecca Romero: ‘Simulation and Chemical Probing of Trinucleotide Repeat DNA’
Pornchai Rojsitthisak: ‘The Mechlorethamine C-C Crosslink’
Huynh-Hoa Bui: ‘Computer Prediction of Peptide / MHC Complex Structure’
Ashutosh Kulkarni: ‘Structure-Function Studies on hPepT1’ (joint with Vincent Lee)
Eric Price: ‘Computer Modeling of DNA and RNA’
Melina Bayramyan: ‘Analysis of Protein-RNA Complexes’
Jennifer Links: ‘Structure-Function Studies on hPepT1’ (joint with Vincent Lee)
Alexandra Schiewe: ‘Structural Prediction of MHC-Peptide-TCR Complexes’
Brian Sutch: ‘Molecular Design of Nucleic Acid Aptamers’
Ma’mon Hatmal: ‘Computer Modeling of Spin-labeled Biomolecules’
Yiyu Li: ‘Computer Modeling of Spin-labeled Proteins’
Asma El-Magboub: ‘Biopharmaceutical Modeling of Low Solubility Drugs’
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2014-
Dab Brill: ‘Solvated Molecular Docking’
Masters
2001-2003
2001-2003
2001-2004
2001-2004
2002-2004
2006-2009
Manisha Murthy: ‘Computer Prediction of Nucleic Acid-Protein Interactions’
Kaushal Parikh: ‘Computer Prediction of Peptide / MHC Complex Structure’
Scott Gleim: ‘Computer Modeling of Transmembrane Protein Structure’
Yuancao Cui: ‘Computer Modeling of Transmembrane Protein Structure’
Ketan Patel: ‘Computer Modeling of Protein-RNA Association’
Nuttapon Jongaroonngamsang: ‘Liquid Chromatographic and Mass Spectrometric
Determinations of Mechlorethamine-DNA Crosslinks’ (joint with Rojsitthisak P)
2014-2016 Bianfei Xuan: ‘Computer Modeling of the IAPP Fibril'
2015Billy Viriyabancha: ‘Computer Modeling of Protein-Cyclodextrin Interactions'
2015Yasmin Bahreini: ‘Computer Modeling of Drug-Cyclodextrin Complexes'
2016Jason Giles: ‘Computer Modeling of MHC-Peptide Complexes'
Research Funding
Design and Preclinical Testing of Novel Macrocyclic TACE inhibitors, Co-PI, PI: Michael
Selsted USC CTSI, $78,093
Structural Analysis of Protein-Membrane Interaction, Co-PI, PI Ralf Langen, 07/01/01- 01/31/13
PepT1: Structure-Function, Sorting and Modulation, Co-P.I., PI: Vincent H.L. Lee, National
Institute for General Medical Sciences, RO1 GM59297-01A1, 3/1/00-2/38/05, $2,028,419.
NIA (P01, Co-PI, PI Dr. Myron Goodman, USC) ‘Triplet Repeat DNA Structure’. 4/1/003/31/03, $200,000.
NHLBI P01 (P01 PI Dr. David Warburton, Children’s Hospital, Los Angeles). P.I. of one of 5
grants in the program project ‘Design of Therapeutic Agents for TGF-beta Inhibition’. 5/1/984/30/03, $750,000.
James H. Zumberge Interdisplinary Research Fund. ‘The Dynamics of Slipped DNA’. 7/1/026/30/03, $37,000.
NATO Travel Award (Dr. Blagbrough IS, University of Bath, UK). ‘Cytotoxic Polyamines
Targeted to DNA: Rational Design, Synthesis and Evaluation’ 5/1/97-4/30/98, $5,600.
NCI R29 CA64299-01 ‘Polyamine - DNA Complexes: Structure and Anti-Tumor Mechanisms’
7/1/94-6/30/99, $346,000 direct costs.
IBM SUR Grant 11/1995 ($20,000 for the purchase of IBM Workstations)
PMA (Pharmaceutical Manufacturers of America) Research Starter Grant. 1/1/94-12/31/95,
$25,000 (second year was relinquished upon receipt of R29)
AACP (American Association of Colleges of Pharmacy) New Investigator Award. 1/1/9312/31/93, $5,000.
NCI Supplemental Funds to IRG-21-33 ‘A Molecular Graphics Core Facility’. 12/1/93-11/30/94,
$46,000; 12/1/94-11/30/95, $10,000.
James H. Zumberge Faculty Research and Innovation Fund. ‘Computer Modelling of the B to Z
Transition of DNA’. 7/1/93-6/30/95, $22,500.
ACS (American Cancer Society) Pilot Project Award IRG-21-33-06. ‘Computer-Aided Design
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of a Triplex Forming DNA Alkylating Anti-Tumor Agent’. 1/1/93-12/31/93, $10,000.
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