Modelling individual and population
dynamics in application to risk
assessment of chemical mixtures
Gonçalo M. Marques
Jan Baas, Starrlight Augustine and Jean-Lou Dorne
[email protected]
Summary
The job:
Tools for ERA based on
DEB for
1. individuals and
populations
2. single compounds
and mixtures
in R
Summary
Literature review
Database
R code
individual model
R code
population model
Literature review
Examples of keywords used:
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DEB
Dynamic Energy Budget
Mixtures
Ecotoxicology
Modelling
Mortality
Growth
Reproduction
Population Dynamics
Individual based modelling
Literature review
Examples of keywords used:
•
•
•
•
•
•
•
•
•
•
DEB
Dynamic Energy Budget
Mixtures
Ecotoxicology
Modelling
Mortality
Growth
Reproduction
Population Dynamics
Individual based modelling

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T. Jager et al., Debkiss or the quest for the simplest generic
model of animal life history. Journal of Theoretical Biology,
328:9-18, 2013
K. Lika et al., The `covariation method' for estimating the
parameters of the standard Dynamic Energy Budget model I:
philosophy and approach. J. Sea Res., 66:270-277, 2011
Literature review
Examples of keywords used:
•
•
•
•
•
•
•
•
•
•
DEB
Dynamic Energy Budget
Mixtures
Ecotoxicology
Modelling
Mortality
Growth
Reproduction
Population Dynamics
Individual based modelling
Refs
General DEB modelling
Effects of mixtures
Population dynamics
18
7
15
DEB
DEBecotox database
DEBecotox database
× (1 + 𝑠)
× (1 − 𝑠)
par
/(1 + 𝑠)
NEC
conc
DEB MoA
DEB MoA
Assimilation
Maintenance
Growth
Reproduction
Survival
DEB MoA
Assimilation
Maintenance
Growth
Reproduction
Survival
Mixtures
Independent action
Assimilation
Maintenance
Growth
Reproduction
Survival
Mixtures
Similar action
Assimilation
Maintenance
Growth
Reproduction
Survival
Mixtures
Quantitative Structure Activity Relationships (QSAR)
Body-size scaling relationships
DEBecotox R package
Add-my-Pet code structure
DEBecotox R package
DEBecotox R package
DEBecotox R package
Typified model
DEB MoA
Group of action
DEBecotox R package
Typified model
DEB MoA
Group of action
DEBecotox R package
Future developments
Literature review
Database
R code
individual model
R code
population model
Thank you!
EFSA, Nov 2015