DERBY-BURTON LOCAL CANCER NETWORK
FILENAME
Carbo7.DOC
CCPG B81
CONTROLLED DOC NO:
CSIS Regimen Name:
CARBO7
Single Agent Carboplatin (AUC=7)
Available for Routine Use in
Derby in-patient
Derby day-case
Derby community
Derby out-patient
Burton in-patient
Burton day-case
Burton community
Burton out-patient
Stage I seminoma of the testis
Adjuvant (following orchidectomy)
Pre-chemotherapy
2
Post-chemotherapy
B
Indication
Treatment Intent
Anti-Emetics
Day 1
Carboplatin
Frequency & duration:
Notes:
1.

Dose = AUC * (GFR + 25) mg
(See notes below)
Intravenous infusion in 500ml
Dextrose 5% over 30 minutes
Single dose
FBC, U&Es, LFTs, HCG, AfP & LDH must be taken prior to Day 1 of each
cycle.
2.
Following a toxicity assessment treatment may be given if:
 Neutrophils > 1.5 x109/L
 Platelets
>100x 109/L
3.
GFR should be estimated or measured as deemed clinically appropriate
e.g.
Cockcroft Gault Formula
Females:
1.04 x (140 – age) x weight (kg)
serum creatinine (micromol/l)
Males:
1.23 x (140 – age) x weight (kg)
serum creatinine (micromol/l)
DATE OF ISSUE: 24.06.15
REVIEWED BY C.WARD
REVIEW DATE: 24.06.17
AUTHORISED BY: Dr P Chakraborti
*** VALID ON DATE OF PRINTING ONLY ***
VERSION 4
PAGE 1 of 2
DERBY-BURTON LOCAL CANCER NETWORK
FILENAME
Carbo7.DOC
CCPG B81
CONTROLLED DOC NO:
CSIS Regimen Name:
CARBO7
For patients with body mass index (BMI) of ≥30 kg/m2 with stable serum
creatinine values, the adjusted body weight (ABW) should be used to
estimate the GFR
i.e.
Ideal Body Weight
Female IBW (kg) = Height in cm - 105
Male IBW (kg) = Height in cm – 100
ABW = IBW + 0.4(actual weight – IBW
If the estimated serum creatinine clearance is <60 ml/minute, then a formal
measurement of the GFR should be considered, using either a 24 hour urine
collection or an isotopic clearance. If the isotopic clearance is measured then
the value uncorrected for body surface area (BSA) should be used in dose
calculations.
4.
Routinely, use AUC = 7
References:
1.
R. T. Oliver , M. Mason, H. Von der Masse, S. P. Stenning, S. Kirk, G. J. Rustin,
G. M. Mead, P. J. J. Ell, On behalf of the MRC Testis Tumour Group and the
EORTC GU Group A randomised comparison of single agent carboplatin with
radiotherapy in the adjuvant treatment of stage I seminoma of the testis,
following orchidectomy: MRC TE19/EORTC 30982. Abstract No. 4517, 2004
ASCO Annual Meeting
DATE OF ISSUE: 24.06.15
REVIEWED BY C.WARD
REVIEW DATE: 24.06.17
AUTHORISED BY: Dr P Chakraborti
*** VALID ON DATE OF PRINTING ONLY ***
VERSION 4
PAGE 2 of 2