18monthPost-Docpositionforsimulationandmodelinginimaging
DosimetrystudiesusingtheGATEMonteCarlosimulationplatformin99mTc-NTP15-5SPECT
imagingtargetingproteoglycansforassessingosteoarthritisresponsetoinnovativetherapeutic
approaches
Supervisor:LydiaMaigne,associateprofessor,HDR
PôlePhysiquepourlaSantéetl’Environnement,http://ppse.in2p3.fr
LaboratoiredePhysiqueCorpusculaireUMR6533
CampusUniversitairedesCézeaux
4,avenueBlaisePascal,TSA60026,CS60026
63178-AubièreCedex
France
Contact:
LydiaMaigne:[email protected]
Context:
A-SPECTprojectaimsatofferingatshortertermanewradiopharmaceutical(called99mTc-NTP15-5
andcoveredbytheworldpatentWO01/00621A1),fortargetingproteoglycansasmajoractorsin
osteoarthritis pathways, and allowing a functional molecular joint imaging in nuclear medicine.
Considering the portfolio of radiotracers routinely used or under development in nuclear
medicine,thereisnoradiotracersabletotargetcartilageas 99mTc-NTP15-5does.Such 99mTc-NTP
15-5imagingofjointhastheopportunitytoprovidenewstartingpointstoimprovepatientfollowupand“accelerate”developmentofinnovativetherapies.
In order to demonstrate this hypothesis, and to characterize 99mTc-NTP 15-5 radiotracer, a
collaborativeprogramcombiningbothtoxicologystudiesandpreclinicalresearchhasbeenbuilt.
Objectivestotackleintheprojectare:
(i) therelevanceof99mTc-NTP15-5imagingforassessinginnovativeDMOADapproaches,that
appearedpromisingin2014forclinicalapplication,withtheopportunitytobridgethe
gapbetweenpreclinicalandclinicaltesting.
(ii) thedosimetryprofileassociatedto99mTc-NTP15-5imagingofcartilage
(iii) theextendedtoxicologyprofileof 99mTc-NTP15-5asrecommendedbyANSM,inviewofa
futureclinicaltransfer
Descriptionoftheproject:
In the department for Health & Environment of LPC Clermont-Ferrand, we wish to
implement the dosimetry associated to 99mTc-NTP 15-5 imaging of cartilage for rabbits and
extrapolatesuchdosimetryforhuman.
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Actionstofulfillduringthe18-monthperiod:
CollectthebiodistributiondataandSPECTimagingof 99mTc-NTP15-5imagingofcartilage
forrabbits.
Preparethe3DnumericalratphantomsfromCTscansandelaboratethesegmentationof
organs(especiallyliver,kidneysandbonemarrow)
Implement GATE Monte Carlo simulations in order to calculate S-factor and dose for
rabbits.
Asafirstapproximationandintheobjectiveofaclinicaltransfer,implementGATEMonte
CarlosimulationsinordertocalculateS-factorsanddoseforhuman.
Throughtheseactions,thecandidatewillparticipatetotheimprovementandvalidationofthe
GATEMonteCarlosimulationfordosimetrypurposeinpreclinicalradiationtherapy.
The candidate will join an active multidisciplinary research group composed of physicists,
computerscientists,biologistsandphysicians.
This project requires skills in medical physics and computer science. The knowledge of
different Monte Carlo algorithms and / or software will be highly appreciated, especially the
knowledgeoftheC++language.Amedicalphysicsgraduateismorethanwelcomewithastrong
backgroundinnuclearmedicine.
Salary:2000€/month
Employer:UniversityBlaisePascal
Location:LaboratoiredePhysiqueCorpusculaire,UMR6533,Clermont-FerrandandJeanPerrin
Cancercentre
Duration:18months,from1stofFebruary2016to31stofJuly2016
Formoreinformation:
LaboratoiredePhysiqueCorpusculaire:http://clrwww.in2p3.fr
DepartmentforHealthandEnvironmentofLPC:http://ppse.in2p3.fr
OpenGATEcollaboration:http://www.opengatecollaboration.org
Tocandidate:
SendyourCVwithyourPhDmanuscriptorlastpublicationstogetherwithacoverletterbyemail
to:[email protected]
Ifyourapplicationissuccessful,youwillbecontactedforaninterview
Deadlinetocandidate:1stofJanuary2016