Inflammation rapidly reorganizes mouse bone marrow B
cells and their environment in conjunction with early IgM
responses
by Joshua M. Moreau, Alexandra Berger, Megan E. Nelles, Michael Mielnik, Caren
Furlonger, Selena Y. Cen, Rickvinder Besla, Clinton S. Robbins, and Christopher J.
Paige
Blood
Volume 126(10):1184-1192
September 3, 2015
©2015 by American Society of Hematology
During systemic inflammation B cells accumulate in the bone marrow prior to full onset of
emergency granulopoiesis.
Joshua M. Moreau et al. Blood 2015;126:1184-1192
©2015 by American Society of Hematology
The expanded IgD+ population is composed mostly of naive, nonproliferating, B-2 lineage cells.
Joshua M. Moreau et al. Blood 2015;126:1184-1192
©2015 by American Society of Hematology
Accumulating B cells are derived from the recirculating lymphocyte pool.
Joshua M. Moreau et al. Blood 2015;126:1184-1192
©2015 by American Society of Hematology
Inflammation enhances B-cell sensitivity to CXCL12.
Joshua M. Moreau et al. Blood 2015;126:1184-1192
©2015 by American Society of Hematology
IL-1R is required for B-cell accumulation and CXCL12 responses.
Joshua M. Moreau et al. Blood 2015;126:1184-1192
©2015 by American Society of Hematology
IFA causes reorganization of the bone marrow B-cell environment.
Joshua M. Moreau et al. Blood 2015;126:1184-1192
©2015 by American Society of Hematology
Rapid formation of IgM-secreting cells is coupled to CXCR4-dependent localization in the bone
marrow.
Joshua M. Moreau et al. Blood 2015;126:1184-1192
©2015 by American Society of Hematology