Associação de estratégias nutricionais e treinamento físico na prevenção do
declínio cognitivo associado ao envelhecimento
Profª. Drª. Danusa Dias Soares
Universidade Federal de Minas Gerias - UFMG
LAFISE- Laboratório de Fisiologia do Exercício
.
Educação Física e Velhice
Perfil da população idosa no Brasil
2010 a 2013
esporte.gov.br/diesporte
2010 a 2013
esporte.gov.br/diesporte
2010 a 2013
esporte.gov.br/diesporte
Flavanóis do Cacau
ECO²DIA
Effects of Exercise and COcoa flavanols on COgnitive functions in
Type 1 DIAbetes.
Acute MRI COCOA Study UZ
Brussels,
BELGIUM
August / September 2015
HUMAN STUDIES
ACUTE Exercise + Cocoa study,
CHRU
LILLE
Winter – spring 2016
CHRONIC Exercise + COCOA Study,
UZ Brussels / BLITS / BASIC FIT
BELGIUM
2015-2016
Exercício associado ao flavanol do cacau
Pro – inflammatory cytokines
(Ellinger & Stehle; 2016; Selmi et al. 2006)
Anti– inflammatory cytokines
(Ellinger & Stehle; 2016; Selmi et al. 2006)
Increase anti oxidant capacity and
protect cells from ROS
(Myburgh 2014, Allgrove et al. 2011; Davison et al. 2012; Fraga et al.
2005)
Improve vascular function and
vasoreactivity
(Davison et al. 2008; Heiss et al. 2005; Flammer et al. 2012; Berry et al. 2010;
Schroeter et al. 2006)
• Acute or chronic intake of cocoa did not improve
exercise performance or recovery (Allgrove et al. 2011, Davison et al.
2012; Patel et al. 2015; Peschek et al. 2014; Stellingwerf et al. 2014; Taub et al. 2013)
• Levels of oxidative stress (F2 isoprostane, oxidized
LDL’s, MDA) were reduced by the acute or subchronic (14days) intake of CF. (Allgrove et al. 2011, Davison et al. 2012; Sign
et al. 2006; Fraga et al. 2005)
• Increase in DBP after exercise was tempered in
obese people. FMD was increased after acute and
chronic intake of Cocoa Flavanols. (Berry et al. 2010; Patel et al. 2015;
Sign et al. 2006)
• Cocoa flavanol intake increased FFA during exercise,
but had no effect on glucose, insulin, glucagon and
cortisol levels. (Allgrove et al. 2011, Davison et al. 2008; Stellingwerf et al. 2014)
Flavanóis do Cacau e Exercício
Inhibition of LArginase
Inhibition of
NADPH oxidase
↑NO production
↓NO
inactivation
↓anion superoxide
(indirectly reflected by a
decrease in markers of
oxidative stress damage)
↑NO bio
availability
↑Mitochondrial
Function
↑anti oxidant
defences
↑FMD (endothelial
function)
↑Exercise-induced
increased vasoreactivity ?
Improve acute exercise
recovery ?
↓ cytokine
production
↓oxidative stress
& inflammation
Sokolov et al, 2013
Sokolov et al, 2013
40 ANOS DO LAFISE em 2016