Impact of Aortic Valve Replacement on Outcome of
Symptomatic Patients With Severe Aortic Stenosis With
Low Gradient and Preserved Left Ventricular Ejection
FractionClinical Perspective
by Alper Ozkan, Rory Hachamovitch, Samir R. Kapadia, E. Murat Tuzcu, and
Thomas H. Marwick
Circulation
Volume 128(6):622-631
August 6, 2013
Copyright © American Heart Association, Inc. All rights reserved.
Patient population and study design.
Alper Ozkan et al. Circulation. 2013;128:622-631
Copyright © American Heart Association, Inc. All rights reserved.
Unadjusted analysis of survival of patients who underwent aortic valve replacement (AVR) and
those who received standard medical therapy.
Alper Ozkan et al. Circulation. 2013;128:622-631
Copyright © American Heart Association, Inc. All rights reserved.
After adjustment for demographic variables (†) and a Society of Thoracic Surgeons score–based
model (‡), aortic valve replacement (AVR) was found to be independently associated with better
outcome (please see the text and Table 3 for models).
Alper Ozkan et al. Circulation. 2013;128:622-631
Copyright © American Heart Association, Inc. All rights reserved.
A, In an unadjusted analysis (¶) of patients with normal flow and low flow, patients with normal
flow had a better outcome than the low-flow group.
Alper Ozkan et al. Circulation. 2013;128:622-631
Copyright © American Heart Association, Inc. All rights reserved.
After age, sex, treatment, and propensity score adjustment, patients who underwent aortic valve
replacement (AVR) had a better outcome regardless of flow pattern.
Alper Ozkan et al. Circulation. 2013;128:622-631
Copyright © American Heart Association, Inc. All rights reserved.