SimBiology for PBPK and Mechanistic Modeling
Fulden Buyukozturk
MathWorks
© 2016 The MathWorks, Inc.
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SimBiology Overview
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Interactive graphical interface for model building
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Rich set of model exploration and analysis tools
•
MATLAB integration provides flexibility and extensibility
•
Performance scales well with model complexity
Performance scales well with model complexity
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Demo: PBPK model for Trichloroethylene (TCE)

Implement and characterize PBPK model
for TCE in SimBiology

Using the model, explore the effect of:
• TCE dose levels on production of TCE
metabolites
• Variability in parameters on dose-response
relationship
Fisher, J. W., Mahle, D., & Abbas, R. (1998). A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites,
trichloroacetic acid and free trichloroethanol. Toxicology and applied pharmacology, 152(2), 339-359.
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Demo
emo
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Why use SimBiology
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Building complex mechanistic models is easy • Graphical interface
Graphical interface
• Rich set of analysis tasks
•
MATLAB integration provides flexibility and extensibility
• Extend analysis beyond standard tasks
• Automate analyses
Automate analyses
•
Simulation performance scales well with model complexity
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Resources
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Find out more about SimBiology at: http://www mathworks com/help/toolbox/simbio/
http://www.mathworks.com/help/toolbox/simbio/
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Examples and videos available on: http://www.mathworks.com/pkpd
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Models from community available on (search “SimBiology”):
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http://www.mathworks.com/matlabcentral/fileexchange/
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