上海中医药大学研究生导师信息表
姓 名
陈瑜
性
别
女
民
族
汉
出生年月
1975．4
学
历 研究生 学
位
博士
技术职称
教授
导
类
师
别
博士生导师
二级学院
岳阳医院
职
务
实验室主任
从事专业
研究方向
中西医结合临床
专业
代码
100602
眼底病及心血管病中西医结合防治
发表论文
1) Chen Y*, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks
MJ., Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K*.
Synergistically acting agonists and antagonists of G protein-coupled receptors prevent
photoreceptor cell degeneration. Sci Signal. (in press) (*corresponding author)
2) Yang Q, Cui J, Wang P, Du X, Wang W, Zhang T*, Chen Y*. Changes in
interconnected pathways implicating microRNAs are associated with the activity of
apocynin in attenuating myocardial fibrogenesis. Eur J Pharmacol. 2016, 784:22-32
(*corresponding author)
近五年研
究
成果
3) Bian M, Du X, Cui J, Wang P, Wang W, Zhu W, Zhang T, Chen Y*. Celastrol
protects mouse retinas from bright light-induced degeneration through inhibition of
oxidative stress and inflammation. J Neuroinflammation. 2016,13:50
(*corresponding author)
4) Chen Y, Perusek L, Maeda A. Autophagy in light-induced retinal damage. Exp
Eye Res. 2016, 144: 64-72
5) Chen Y, Palczewski K. Systems Pharmacology Links GPCRs with Retinal
Degenerative Disorders. Annu Rev Pharmacol Toxicol. 2016, 56: 273-298
6) Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y,
Palczewski K, Maeda A. A2E Accumulation and the Maintenance of the Visual Cycle
are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J
Biol Chem. 2015, 290: 29035-29044
7) Minqi Xiong, Chenglin Jia, Jingang Cui, Peiwei Wang, Xiaoye Du, Qinbo Yang,
Yuling Zhu, Wenjian Wang, Teng Zhang *, Yu Chen*. Shexiang Tongxin Dropping
Pill attenuates atherosclerotic lesions in ApoE deficient mouse model. J
Ethnopharmacol. 2015, 159: 84-92 (*corresponding author)
8) Qinbo Yang, Chenglin Jia, Peiwei Wang, Minqi Xiong, Jingang Cui, Li Li,
Wenjian Wang, Qingyu Wu, Yu Chen*, Teng Zhang*.microRNA-505 Identified from
Patients with Essential Hypertension Impairs Endothelial Cell Migration and Tube
Formation. Int J. Cardiol, 2014, 177: 925-934 (*corresponding author)
9) Peiwei Wang, Jingang Cui, Xiaoye Du, Qinbo Yang, Chenglin Jia, Minqi Xiong,
Xintong Yu, Li Li, Wenjian Wang, Yu Chen*, Teng Zhang*. Panax notoginseng
saponins (PNS) inhibits breast cancer metastasis. J Ethnopharmacol. 2014, 154:
663-671 (*corresponding author)
10) Li Liu, Jingang Cui, Qinbo Yang, Chenglin Jia, Minqi Xiong, Bingbing Ning,
Xiaoye Du, Peiwei Wang, Xintong Yu, Li Li, Wenjian Wang, Yu Chen*, Teng Zhang*.
Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis.
Biochem Biophys Res Commun. 2014. 449: 55-61. (*corresponding author)
11) Chenglin Jia, Minqi Xiong, Peiwei Wang, Jingang Cui, Xiaoye Du, Qinbo Yang,
Wenjian Wang, Yu Chen*, Teng Zhang*. Notoginsenoside R1 attenuates
atherosclerotic lesions in ApoE deficient mouse model. PLOS ONE. 2014. 9 (6):
e99849. (*corresponding author)
12) Qinbo Yang, Xiaoyan Wang, Jingang Cui, Peiwei Wang, Minqi Xiong, Chenglin
Jia, Li Liu, Bingbing Ning, Li Li, Wenjian Wang, Yu Chen*, Teng Zhang1,2*.
Bidirectional regulation of angiogenesis and miR-18a expression by PNS in the
mouse model of tumor complicated by myocardial ischemia. BMC Complementary
and Alternative Medicine. 2014. 14: 183. (*corresponding author)
13) Yu Chen, Grazyna Palczewska, Debarshi Mustafi, Marcin Golczak, Zhiqian
Dong, Osamu Sawada, Tadao Maeda, Akiko Maeda, and Krzysztof Palczewski.
Systems Pharmacology Approach to Prevent Retinal Degeneration in Stargardt
Disease. Journal of Clinical Investigation, 2013; 123:5119-5134
14) Hideo Kohno, Yu Chen, Brian M Kevany, Eric Pearlman, Masaru Miyagi, Tadao
Maeda, Krzysztof Palczewski, and Akiko Maeda. Photoreceptor proteins initiate
microglial activation via Toll-like receptor 4 in retinal degeneration mediated by
all-trans-retinal. Journal of Biological Chemistry, 2013; 288:15326-15341
15) Yu Chen, Osamu Sawada, Hideo Kohno, Yun-Zheng Le, Carlos Subauste, Tadao
Maeda and Akiko Maeda. Autophagy protects the retina from light-induced
degeneration. Journal of Biological Chemistry, 2013; 288:7506-7518
16) Tianzhan Wang, Yu Chen, Yanmin He, Xiaodong Fu, Yi Wang, Yanqiu Xu,
Hongjie Yang, Hongli Xue, Yi Liu, Xiaotao Feng, Teng Zhang, Wenjian Wang. Effects
of Chinese Herbal Medicine Yiqi Huanju Qingli Formula in metabolic syndrome
patients with microalbuminuria: a randomized placebo-controlled trial. Journal of
Integrative Medicine, 2013;11:175-183
17) Yi Chen, Deyu Fu, Yu Chen, Yanmin He, Xiaodong Fu, Yanqiu Xu, Yi Liu,
Xiaotao Feng, Teng Zhang, Wenjian Wang. Effects of Chinese herbal medicine Yiqi
Huanju Qingli Formula on hypertensive patients with metabolic syndrome: a
randomized, placebo-controlled
2013;11:184-194
trial.
Journal
of
Integrative
Medicine,
18) Taiqing Huang, Yiwei Wang, Ebrahem, Yu Chen, Cindy Cheng, Yongqiu
Doughman, Michiko Watanabe, Sally L Dunwoodie and Yu-Chung Yang. Deletion of
HIF-1α partially rescues the abnormal hyaloid vascular system in Cited2 conditional
knockout mouse eyes. Molecular Vision, 2012;18:1260-1270
19) Jinwei Du, Yu Chen, Qiang Li, Xiangzi Han, Cindy Cheng, Zhengqi Wang,
David Danielpour, Sally L. Dunwoodie, Kevin D. Bunting，and Yu-Chung Yang.
HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence
caused by Cited2 deficiency. Blood, 2012;119:2789-2798
20) Kiichiro Okano, Akiko Maeda, Yu Chen, Vishal Chauhan, Johnny Tang,
Grazyna Palczewska, Tsutomu Sakai, Hiroshi Tsuneoka, Krzysztof Palczewski, and
Tadao Maeda. Retinal rod and cone photoreceptor cells in mouse models exhibit
differential susceptibility to light−induced damage. Journal of Neurochemistry,
2012;121:146-156
21) Yu Chen, Kiichiro Okano, Tadao Maeda, Vishal Chauhan, Marcin Golczak,
Akiko Maeda, and Krzysztof Palczewski. Mechanism of all-trans-retinal toxicity with
implications for stargardt disease and age-related macular degeneration. Journal of
Biological Chemistry, 2012;287: 5059-5069
22) Akiko Maeda, Marcin Golczak, Yu Chen, Kiichiro Okano, Hideo Kohno,
Satomi Shiose, Kaede Ishikawa, William Harte, Grazyna Palczewska, Tadao Maeda,
and Krzysztof Palczewski. Primary amines protect against retinal degeneration in
mouse models of retinopathies. Nature Chemical Biology, 2011;8:170-178
23) Qubo Zhu, Wenyu Sun, Kiichiro Okano, Yu Chen, Ning Zhang, Tadao Maeda,
and Krzysztof Palczewski. A sponge transgenic mouse model reveals important roles
for the miRNA-183/96/182 cluster in post-mitotic photoreceptors of the retina.
Journal of Biological Chemistry, 2011; 286:31749-31760
24) Satomi Shiose, Yu Chen, Kiichiro Okano, Sanhita Roy, Hideo Kohno, Johnny
Tang, Eric Pearlman, Tadao Maeda, Krzysztof Palczewski, and Akiko Maeda.
Toll-like receptor 3 is required for development of retinopathy caused by impaired
all-trans-retinal clearance in mice. Journal of Biological Chemistry, 2011; 286:
15543-15555
获奖
2016 年：“凉开法”抗动脉粥样硬化效应与 microRNA 调控机制，上海中西医结
合科学技术奖，一等奖，排名第一
2014 年：明治生命科学奖（科学奖）
2013 年：“同病类证”理论指导下的代谢综合征组分疾病防治，中国中西医结合
学会科学技术奖，一等奖，排名第六
2013 年：基于“同病类证”理论的代谢综合征组分疾病中西医结合防治策略，上
海市科学技术奖，二等奖，排名第六
人才项目
2016 年度
2012 年度
2013 年度
2014 年度
上海中医药大学“上海市高原高峰学科”讲席教授
上海市教委高校特聘教授（东方学者）
上海市科委浦江计划
上海市教委曙光计划
*请按课题名称、课题级别及来源、课题经费**万元填写
国家自然科学基金面上项目，81473732，石斛夜光丸调控 Gq-GPCR/PLC/氧化应
激通路干预视网膜光损伤的效应机制研究， 2015/01-2018/12， 70 万元
目前在研
课题
招生
类别
上海市教委曙光学者计划，13SG42，补肾中药保护光感受器细胞的效应及机制
研究，2014/01-2016/12，15 万元
学生
类别
硕士、博士
学位
类别
医学科学学位