An acid-base equilibrium (top) shares many aspects of a nucleophilic substitution reaction (bottom). Both reactions involve species that donate an electron lone pair (Lewis bases, B: and Nu:) and species that accept an electron lone pair (Lewis acids, H–A and E–L). Source: Nucleophilic Substitution, Addition, and Elimination Reactions, The Organic Chemistry of Medicinal Agents Citation: Renslo A. The Organic Chemistry of Medicinal Agents; 2016 Available at: http://mhmedical.com/ Accessed: July 31, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
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