Simultaneous Coronary Pressure and Flow Velocity
Measurements in Humans
by Bernard de Bruyne, Jozef Bartunek, Stanislas U. Sys, Nico H.J. Pijls, Guy R.
Heyndrickx, and William Wijns
Circulation
Volume 94(8):1842-1849
October 15, 1996
Copyright © American Heart Association, Inc. All rights reserved.
Simultaneous pressure and flow velocity recordings at rest (left) and after injection of
intracoronary adenosine (right) in a 69-year-old patient with 62% diameter stenosis in the mid
right coronary artery.
Bernard de Bruyne et al. Circulation. 1996;94:1842-1849
Copyright © American Heart Association, Inc. All rights reserved.
Top, Simultaneous pressure and flow velocity tracings during maximal vasodilatation in the
same patient as in Fig 1.
Bernard de Bruyne et al. Circulation. 1996;94:1842-1849
Copyright © American Heart Association, Inc. All rights reserved.
Plots of relation between the pairs of values of coronary flow velocity reserve (CFVR),
instantaneous hyperemic diastolic velocity pressure slope (IHDVPS), and myocardial fractional
flow reserve (FFRmyo) measured twice consecutively under baseline conditions without any
intervention (BL 1 is baseline 1; BL 2, baseline 2).
Bernard de Bruyne et al. Circulation. 1996;94:1842-1849
Copyright © American Heart Association, Inc. All rights reserved.
A, Coefficient of variation between the pairs of values of coronary flow velocity reserve (CFVR),
instantaneous hyperemic diastolic velocity pressure slope (IHDVPS), and myocardial fractional
flow reserve (FFRmyo) measured twice consecutively under baseline conditions, before and
after increasing heart rate by atrial pacing, before and after lowering blood pressure by
nitroprusside infusion, and before and after increasing contractility by dobutamine infusion.
Bernard de Bruyne et al. Circulation. 1996;94:1842-1849
Copyright © American Heart Association, Inc. All rights reserved.
Plots of relation between the pairs of values of coronary flow velocity reserve (CFVR),
instantaneous hyperemic diastolic velocity pressure slope (IHDVPS), and myocardial fractional
flow reserve (FFRmyo) measured at a heart rate (HR) of 80 bpm (on the x axis) and at a heart rate
of 110 bpm (on the y axis).
Bernard de Bruyne et al. Circulation. 1996;94:1842-1849
Copyright © American Heart Association, Inc. All rights reserved.
Plots of relation between the pairs of values of coronary flow velocity reserve (CFVR),
instantaneous hyperemic diastolic velocity pressure slope (IHDVPS), and myocardial fractional
flow reserve (FFRmyo) measured before and during infusion of nitroprusside (NIP).
Bernard de Bruyne et al. Circulation. 1996;94:1842-1849
Copyright © American Heart Association, Inc. All rights reserved.
Plots of relation between the pairs of values of coronary flow velocity reserve (CFVR),
instantaneous hyperemic diastolic velocity pressure slope (IHDVPS), and myocardial fractional
flow reserve (FFRmyo) measured before and during infusion of dobutamine (DOB).
Bernard de Bruyne et al. Circulation. 1996;94:1842-1849
Copyright © American Heart Association, Inc. All rights reserved.